Curriculum Vitae of Carlo Giorgio Giussani, MD, PhD

Personal informations Born in Milan, Italy, 9th April 1976. Citizenship: Italian. Work phone number: +39 039 233 3494/3496/3497. Fax: +39 039 2301589 Cell phone number: +39 338 4709943 E-mail: [email protected]

Education - June 1995: High School Degree of Maturità Classica at the Istituto Leone XIII of Milan, final score 58 out of 60. - July 2001: he completes the Medical School at the Università degli Studi di Milano, final votation 110 out of 110 cum laude. - April 2002: he is enrolled in the Neurosurgery Residency Program, Neurosurgery, Dept. of Neurological Sciences, Università degli Studi di Milano. - November 2006: he completes the Neurosurgery Residency Program at the Università degli Studi di Milano, final votation 70/70 cum laude - USMLE: United States Medical Licensing Examination obtained in August 2007
ECFMG (Educational Commission for Foreign Medical Graduates) certified - July 2008 to May 2009 Senior Fellow in Pediatric Neurosurgery, Dept. of Neurological Surgery, University of Washington, Seattle Children’s Hospital, Seattle WA. Under the direction of Professor Richard G. Ellenbogen and Jeffrey Ojemann. - In June 2011: Dr. Giussani obtains the PhD (Research Doctorate) in Neuropsychology at the University Paul Sabatier of Toulouse, France, under the direction of Professor Franck-Emmanuel Roux and Professor Jean François Dèmonet. Languages: command of English and French.

Fellowships and Research Experiences

- September 2001- June 2002: J 1 VISA to work as Research Fellow at the Brain Tumor Laboratory of the Department of Neurosurgery of Brigham and Women's Hospital, Harvard Medical School, Boston under the direction of Professor Peter M. Black and Dr. Rona S. Carroll. - November 2005 to November 2006 (fifth year of residency program) Resident at the Dept. of Neurosurgery, Universite’ Paul Sabatier de Toulouse, France, under the direction of Professor Franck-Emmanuel Roux and Professor Michel Tremoulet, Chairmen of Neurosurgery
fellowship in Brain Tumor Surgery and Human Brain Mapping. Service de Neurochirurgie, Centre Hospitalier Universitaire Purpan, Toulouse, France. - January 2007 to November 2007 Neuro-Oncology and Brain Mapping Fellow (Assegnista di Ricerca) at the Division of Neurosurgery, Dept. of Neurological Sciences of the Universita’ degli Studi di Milano, under the direction of Professor Sergio Maria Gaini and Professor Lorenzo Bello. Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS , via F. Sforza 35, 20122, Milano. Telephone: +39-0255035502. Fax: +39-0259902239/0250320416 .

Current positions From May 2009 Consultant Neurosurgeon at the Clinica Neurochirurgia, Università degli Studi Milano-Bicocca, Osp. San Gerardo dei Tintori, via Pergolesi 33, Monza, Italy. Telephone: +39 039 233 3494/3496/3497. Fax: +39 039 2301589. In charge of the development of the pediatric neurosurgery program. From April 1 2010 Dr. Giussani is a foreign affiliated Assistant Professor of Neurological Surgery at the Department of Neurological Surgery, University of Washington, Seattle, USA. From December 2010 Ricercatore in Neurochirurgia (Assitant Professor of Neurosurgery), at the Università degli Studi Milano-Bicocca.

Papers published 2001 1) Low-dose Chemotherapy Combined with an Antiangiogenic Drug Reduces Human Glioma Growth in Vivo. L. Bello, G. Carrabba, C. Giussani, V. Lucini, F. Cerutti, F. Scaglione, J. Landré, M. Pluderi, G. Tomei, R. Villani, R.S. Carroll, P. McL Black, A.Bikfalvi. Cancer Research 61, October 17, 2001. 2) Simultaneous Inhibition of Glioma Angiogenesis, Cell Proliferation, and Invasion by a naturally Occurring fragment of Human metalloproteinase-2. L. Bello, V. Lucini, G. Carrabba, C. Giussani, M. Machluf, M. Pluderi, D. Nikas, J. Zhang, G. Tomei, R.M. Villani, R.S. Carroll, A. Bikfalvi, P.M. Black. Cancer Research 61, December 15, 2001. 2002 3) Suppression of Malignant Glioma Recurrence, in a Newly Developed Animal Model by Endogenous Inhibitors. L. Bello, C. Giussani, G. Carrabba, M. Pluderi, V. Lucini, M. Pannacci, D. Caronzolo, G. Tomei, R. Villani, F. Scaglione, R.S. Carroll, P. M. Black. Clinical Cancer Research 8, November 2002. 4) Domain Swapping in COOH-terminal Fragment of Platelet Factor 4 Generates Potent Angiogenesis Inhibitors. M. Hagedorn, L. Zilberberg, J. Wilting, X. Canron, G. Carrabba, C. Giussani, M. Pluderi, L. Bello, A. Bikfalvi. Cancer Research 62, December 1, 2002. 2003 5) IS201, a Specific alphavbeta 3 Integrin Inhibitor, Reduces Glioma Growth in Vivo. L. Bello, V. Lucini, C. Giussani, G. Carrabba, M. Pluderi, F. Scaglione, G. Tomei, R. Villani, A. Bikfalvi, P.M. Black, R.S. Carroll. Neurosurgery 52, January, 2003. 6) Local Intracerebral Delivery of Endogenous Inhibitors by Osmotic Minipumps Effectively Suppresses Glioma Growth in Vivo. C. Giussani, G. Carrabba, M. Pluderi, V. Lucini, M. Pannacci, D. Caronzolo, F. Costa, M. Minotti, G. Tomei, R. Villani, A. Bikfalvi, L. Bello. Cancer Research 63,May 15, 2003.

7) Long-Term Inhibition of Glioma Growth by Systemic Administration of Human PEX. M. Pluderi, V. Lucini, D. Caronzolo, M. Pannacci, F. Costa, G. Carrabba, C. Giussani, S.Grosso, F. Colleoni, F. Scaglione, R. Villani, A. Bikfalvi, L. Bello. J Neurosurg Sci. 2003 Jun;47(2):69-78 2004 8) Antiangiogenic Therapy by Local Intracerebral Microinfusion Improves Treatment Efficiency and Survival in an Orthotopic Human Glioblastoma Model. N.O. Schmidt, M. Ziu, G. Carrabba, C. Giussani, L. Bello, Y. Sun, K. Schmidt, M. Albert, P. McL Black, R.S. Carrol. Clinical Cancer Research, vol 10. February 15, 2004.

9) Combinatorial Administration of Molecules That Simultaneously Inhibit Angiogenesis and Invasion Leads to Increased Therapeutic Efficacy in Mouse Models of Malignant Glioma. L. Bello, V.Lucini, F. Costa, M. Pluderi, C. Giussani, F. Acerbi, G. Carrabba, M. Pannacci, D. Caronzolo, S. Grosso, S. Shinkaruk, F. Colleoni, X. Canyon, G. Tomei, G. Deleris, A.Bikfalvi. Clinical Cancer Research, vol 10. July 1, 2004. 2006 10) Intraoperative Language Localization in Multilingual Patients with Gliomas. L. Bello, F. Acerbi, C. Giussani, P. Baratta, P. Taccone, V. Songa, M. Fava, N. Stocchetti, C. Papagno, SM Gaini. Neurosurgery vol 59: 115-125. 2006. 11) Subcortical motor mapping: what DTI tractography adds to intraoperative monitoring. L. Bello, E. Fava, G. Carrabba, C. Giussani, F. Portaluri, A. Castellano, A. Gambini, S.M. Gaini, A. Falini. Rivista Medica vol 12, N 1-2: 23-27. 2006.

12) Motor brain mapping with polygraphic recording of EMG responses and of cerebral activity. E. Fava, F. Lang, L. Bello, G. Carrabba, C. Giussani, F. Portaluri, V. Conte, N. Stecchetti, S.M. Gaini. Rivista Medica vol 12, N 1-2: 23-27. 2006. 2007 13) Intraoperative subcortical language tract mapping guides surgical removal of gliomas involving speech areas. Bello L, Gallucci M, Fava M, Carrabba G, Giussani C, Acerbi F, Baratta P, Songa V, Conte V, Branca V, Stocchetti N, Papagno C, Gaini SM. Neurosurgery vol 60: 1-14, January 2007. 14) Effect of Human Skin-Derived Stem Cells on Vessel Architecture, Tumor Growth, and Tumor Invasion in Brain Tumor Animal Models. Federica Pisati, Marzia Belicchi, Francesco Acerbi,Chiara Marchesi, Carlo Giussani, Manuela Gavina, Sophie Javerzat, Martin Hagedorn, Giorgio Carrabba, Valeria Lucini, Sergio Maria Gaini, Nereo Bresolin, Lorenzo Bello, Andreas Bikfalvi, and Yvan Torrente. Cancer Res 2007; 67: (7). April 1, 2007 15) When “Abegg” is read and (“A, B, E, G, G”) is not: a cortical stimulation study of musical score reading. Franck-Emmanuel Roux, Vincent Lubrano, Jean-Albert Lotterie, Carlo Giussani, Clémence Pierroux, Jean-François Dèmonet. Journal of Neurosurgery vol 106, 1017-1027. 2007 16) Review of language organization in bilingual patients: what can we learn from direct brain mapping? Carlo Giussani, Franck-Emmanuel Roux, Vincent Lubrano, Sergio M. Gaini, Lorenzo Bello. Acta Neurochirurgica 17) Cortical and subcortical motor mapping in rolandic and perirolandic glioma surgery: impact on postoperative morbidity and extent of resection. Giorgio Carrabba, Carlo Giussani, Enrica Fava, Francesco Acerbi, Francesco Portaluri, Valeria Songa, Nino Stecchetti, Vincenzo Branca, Sergio M. Gaini, Lorenzo Bello. J Neurosurg Sci. 2007 Jun;51(2):45-51. 18) Motor and language DTI Fiber Tracking combined with intraoperative subcortical mapping for surgical removal of gliomas. Bello L, Gambini A, Castellano A, Carrabba G, Acerbi F, Fava E, Giussani C, Cadioli M, Blasi V, Casarotti A, Papagno C, Gupta AK, Gaini S, Scotti G, Falini A. Neuroimage. 2007 Aug 29. 2008 19) Cortical areas involved in Arabic number reading. Roux FE, Lubrano V, Lauwers-Cances V, Giussani C, Démonet JF. Neurology. 2008 Jan 15;70(3):210-7. 20) Who is Who? A cortical stimulation study on Famous Face Naming Areas. Giussani C, Roux FE, Bello L, Lauwers-Cances V, Papagno C, Gaini SM, Puel M, Démonet JF. J Neurosurg. 2009 Feb;110(2):289-99. 2009 21) Severely symptomatic craniovertebral junction abnormalities in children. Long-term reliability of aggressive management. Giussani C, Roux FE, Guerra p, Pirillo D, Grimaldi M, Citerio G, Sganzerla EP. Pediatric Neurosurgery 22) Mirror of the Soul: a cortical stimulation study on face emotions recognition. Giussani C, Pirillo D, Roux FE. J Neurosurg. 2010 Mar;112(3):520-7. 23 ) The graphemic/motor frontal area Exner's area revisited. Roux FE, Dufor O, Giussani C, Wamain Y, Draper L, Longcamp M, Démonet JF. Ann Neurol. 2009 Oct;66(4):537-45. 24) Treatment of intermittent obstructive hydrocephalus secondary to a choroid plexus cyst. Filardi TZ, Finn L, Gabikian P, Giussani C, Ebenezer S, Avellino AM. J Neurosurg Pediatr. 2009 Dec;4(6):571-4.

25) Is postoperative CT scanning predictive of subdural electrode placement complications in pediatric epileptic patients? Giussani C, Filardi T, Bunyaratavej K, Mai JC, Ogino M, Greene S, Browd SR, Avellino AM, Ellenbogen RG, Ojemann JG. Pediatr Neurosurg. 2009;45(5):345-9.

2010 26) Influenza A (H1N1) encephalitis with severe intracranial hypertension. Citerio G, Sala F, Patruno A, Gori A, Grioni D, Rossi M, Giussani C, Grimaldi M. Minerva Anestesiol. 2010 Jun;76(6):459-62. 27) DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. Giussani C, Poliakov A, Ferri RT, Plawner LL, Browd SR, Shaw DW, Filardi TZ, Hoeppner C, Geyer JR, Olson JM, Douglas JG, Villavicencio EH, Ellenbogen RG, Ojemann JG. Neuroimage. 2010 Aug 1;52(1):217-23. . 28) Is preoperative functional magnetic resonance imaging reliable for language areas mapping in brain tumor surgery? Review of language functional magnetic resonance imaging and direct cortical stimulation correlation studies. Giussani C, Roux FE, Ojemann J, Sganzerla EP, Pirillo D, Papagno C. Neurosurgery. 2010 Jan;66(1):113-20. Review. 2011 29) Connectivity constraints on cortical reorganization of neural circuits involved in object naming. Papagno C, Gallucci M, Casarotti A, Castellano A, Falini A, Fava E, Giussani C, Carrabba G, Bello L, Caramazza A. Neuroimage. 2011 Jan 8. [Epub ahead of print] 30) Anatomical correlates for category specific naming of Living and Non-Living Things. Giussani C, Riva M, Gallucci M, Boukhatem L, Sganzerla EP, Demonet JF, Roux FE. Neuroimage. 2011 Feb 3. 31) Sentence translation in proficient bilinguals: A direct electrostimulation brain mapping. Borius PY, Giussani C, Draper L, Roux FE. Cortex. 2011 Mar 4. 32) An Intracranial Aneurysm and Dural Arteriovenous Fistula in a Newborn. Ko A, Filardi T, Giussani C, Ghodke R, Browd SR. Pediatr Neurosurg. 2011 May 3;46(6):450-456. 2012 33) Cavum Veli Interpositi: Just an Anatomical Variant or a Potentially Symptomatic CSF Compartmentalization? Giussani C, Fiori L, Trezza A, Riva M, Sganzerla EP. Pediatr Neurosurg. 2011;47(5):364-8. Epub 2012 May 9. 34) Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: Effects on regional cerebral blood flow. Villa F; Iacca C; Forastieri Molinari A; Giussani C; Aletti G; Pesenti A; Citerio G. Crit Care Med 2012 Vol. 40, No. 10.

35) The association of neural axis and craniovertebral junction anomalies with scoliosis in RubinsteinTaybi syndrome.Giussani C, Selicorni A, Fossati C, Ingelmo P, Canonico F, Landi A, Trezza A, Riva M, Sganzerla EP.Childs Nerv Syst. 2012 Dec;28(12):2163-8. doi: 10.1007/s00381-012-1893-7. Epub 2012 Aug 23. 36) Optimized system for cerebral perfusion monitoring in the rat stroke model of intraluminal middle cerebral artery occlusion. Beretta S, Riva M, Carone D, Cuccione E, Padovano G, Rodriguez Menendez V, Pappadá GB, Versace A, Giussani C, Sganzerla EP, Ferrarese C. J Vis Exp. 2013 Feb 17;(72). doi:pii: 50214. 10.3791/50214. 37) Collagenopathy with a phenotype resembling silver-russell syndrome phenotype. Cianci P, Paterlini G, Tagliabue P, Verderio M, Vergani P, Bianchi ML, Giussani C, Kullmann G, Mazzoleni F, Bozzetti A, Selicorni A. Am J Med Genet A. 2013 Aug 5. doi: 10.1002/ajmg.a.36093. [Epub ahead of print]

Chapters in published books Angiogenesis and Invasion in Gliomas. L. Bello, C. Giussani, G. Carrabba, M. Pluderi, F. Costa, A. Bikfalvi. In Kirsch M and Black PMcL (eds.), Angiogenesis in Brain Tumors, pp 267-289, Boston, Kluwer Academic Publisher, 2003.

Neurosurgical complications and their management in mucopolysaccharidosis. Carlo Giussani, Sara Miori and Erik P. Sganzerla. In Rossella Parini and Generoso Andria Mariani Foundation Pediatric Neurology; 23 (eds.), chapter 11; Lysosomal Storage Diseases early Diagnosis and New Treatment, pp 107-119, 2010.

Neoplasie intracraniche. Erik P. Sganzerla, Carlo Giussani. In Carlo Ferrarese, Core Curriculum, Malattie del Sistema nervoso, pp 265-273, Milano, McGraw-Hill, 2011

Surgery for temporal lobe epilepsy. Cahpter 51, Jeffery J. Ojemann, Carlo Giussani, Carlo Marras. In Richard Ellenbogen, Saleem Abdulrauf, Laligam Sekhar, Principles of Neurological Surgery 3rd Edition, pp 765-772, Philadelphia, Elsevier, 2012

Dr. Giussani is author of more than 70 abstracts published in the proceedings of national and international congresses. He is affiliated from 2006 to the Italian Society for Neurosurgery and is a faculty member of the AO Cranio-maxillo-facial/Neuro section in Italy from 2012