Date of Document: January 18, 2017

CURRICULUM VITAE Sean Lew MD Chief, Professor Department of Neurosurgery

OFFICE ADDRESS: Children's Corporate Center 999 N 92 St Milwaukee, WI 53226 CITIZENSHIP: USA EDUCATION: 08/1987 - 08/1991 B.A., Reed College, Portland, OR 08/1991 - 06/1995 M.D., Oregon Health Sciences University, Portland, OR POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 06/1995 - 06/1996 Internship, General Surgery, University of Vermont, Burlington, VT 07/1996 - 06/2001 Resident in Neurological Surgery, University of Vermont, Burlington, VT 04/1999 - 12/1999 Neurosurgery Fellow, Maine Medical Center, Portland, ME 01/2000 - 03/2000 Orthopedic Spine Surgery, University of Vermont, Burlington, VT 01/2001 - 03/2001 Orthopedic Spine Surgery, University of Vermont, Burlington, VT 04/2001 - 06/2001 Pediatric Neurosurgery, Children’s Hospital, Boston, MA 07/2001 - 06/2002 Chief Resident in Neurological Surgery, University of Vermont, Burlington, VT 07/2003 - 06/2004 Fellow, Pediatric Neurosurgery, Beth Israel Medical Center – Hyman-Newman Institute for Neurology and Neurosurgery, New York City, NY FACULTY APPOINTMENTS: 09/2004 - Present Clinical Instructor, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 09/2004 - 06/2010 Assistant Professor, Department of Neurosurgery, Pediatric Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 07/2010 - Present Associate Professor, Department of Neurosurgery, Pediatric Neurosurgery, Medical College of Wisconsin, Milwaukee, WI ADMINISTRATIVE APPOINTMENTS: 07/2008 - Present Program Director, Neurosurgery Epilepsy, Children's Hospital of Wisconsin, Milwaukee, WI HOSPITAL STAFF PRIVILEGES: 09/2004 - Present Aurora St. Luke’s Medical Center, 2900 W. Oklahoma Avenue, Milwaukee, WI 53215 09/2004 - Present Aurora Sinai Medical Center, 945 N. 12th Street, Milwaukee, WI 53233 09/2004 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 09/2004 - Present Wheaton Franciscan Healthcare – St. Joseph, 5000 W. Chambers Street, Milwaukee, WI 53210 09/2004 - Present Children’s Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226 SPECIALTY BOARDS AND CERTIFICATION: Board Certified

Issue Date

Expiration

American Board of Neurological Surgery American Board of Pediatric Neurological Surgery

11/2007 12/2008

11/2017 12/2018

Certificates Advanced Cardiac Life Support Advanced Trauma Life Support (instructor) United States Medical Licensure Examination, Parts I-III Basic Life Support Advanced Trauma Life Support Instructor

Issued By AHA

Issue Date 06/1995

Expiration 06/2002

ACS

07/1998

None

08/1998

None

AHA

06/1999 07/2000

06/1998 07/2013

Licensure Vermont Maine Massachusetts New York Wisconsin

Number

Issue Date 06/1995 07/1999 04/2001 07/2003 07/2004

Expiration 2002 07/2001 04/2002 07/2005 10/2011

47155

AWARDS AND HONORS: 01/1989 - 06/1990 Dean’s List, Reed College, Portland, Oregon 06/1990 - Present Research Fellowship, American Heart Association 06/1992 - Present Otolaryngology Student Research Fellowship, Oregon Health & Science University, Portland, Oregon 06/2001 - Present Donaghy Clinical Research Award, Division of Neurosurgery, University of Vermont, Burlington,Vermont 05/2007 - Present Best Doctors in America 2007-2008 12/02/2007 - Present Abstract, Selected for Investigators’ Workshop Poster Session for outstanding abstracts on topics related to basic science and research, American Epilepsy Society Annual Meeting, Philadelphia, Pennsylvania 12/02/2007 - Present Abstract, Selected for Investigators’ Workshop Poster Session for outstanding abstracts on topics related to basic science and research , American Epilepsy Society Annual Meeting, Philadelphia, Pennsylvania 06/2008 - Present Patient’s Choice Award, 2008 09/2009 - Present Best Doctors in America 2009-2010 11/2010 - Present Best Doctors in America 2011-2012 01/2011 - Present Patient’s Choice Award, 2010 MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: 06/1999 - 06/2002 Congress of Neurological Surgeons (Resident Member) 06/1999 - 06/2002 American Association of Neurological Surgeons (Resident Member) 07/2004 - Present Congress of Neurological Surgeons (Active Member) 07/2005 - Present American Association of Neurological Surgeons (Active Member) 08/2005 - Present AANS/CNS Joint Section on Pediatric Neurosurgery (Active Member) 10/2005 - Present International Society for Pediatric Neurosurgery (Active Member) 08/2007 - Present American Epilepsy Society (Active Member) 11/2007 - Present Pediatric Craniocervical Society (Charter Member) 10/2009 - Present American College of Surgeons (Fellow) 07/2010 - Present American Association of Neurological Surgeons (Fellow)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: Journal Review 06/2006 - Present Ophthalmic Plastic and Reconstructive Surgery 07/2008 - Present Journal of Pediatric Hematology and Oncology 09/2008 - Present Child Nervous System 07/2010 - Present Advances in Orthopedics NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 01/2009 - Present Member, Medial Advisory Board, Hemispherectomy Foundation RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: Active Non-Peer Review Title:

Source: Role: Dates: Title: Source: Role: Dates:

Operator Blinded Study of the Efficacy of ShuntCheck,Non-Invasive Device, in Predicting Ventricular Shunt Flow&Clinical Outcome in Children&Adolescents Presenting to Emgncy.Depts&Neurosurgery Clinics Neuro Diagnostic Devices Principal Investigator 08/2008 - Present The Role of Co-Registration of Subdural Electrodes to MRI in Epilepsy Surgery Internal Principal Investigator 03/2009 - Present

INVITED LECTURES/WORKSHOPS/PRESENTATIONS: Local Lew SM, “Cerebral Metastases.”, University of Vermont, Neuroscience Grand Rounds, 09/11/1997 - Present Lew SM. "Blunt Carotid Injury." University of Vermont, Neuroscience Grand Rounds, 10/08/1998 - Present Lew SM, “Pediatric Blunt Carotid Injury.”, University of Vermont, General Surgery Grand Rounds, 11/12/1998 - Present Lew SM. "Head Trauma." Maine Medical Center, Portland, Maine, 09/11/1999 - Present Lew SM, “Tethered Cord Syndrome.”, University of Vermont, Neuroscience Grand Rounds, 05/11/2000 Present Lew SM, “Spinal cord injury – selected topics.”, University of Vermont, Neuroscience Grand Rounds, 03/21/2002 - Present Lew SM, “Spinal cord injury – selected topics.”, University of Vermont, Department of Surgery Grand Rounds, 06/13/2002 - Present Lew SM. "Spinal cord injury - selected topics." Alice Hyde Hospital, Malone, New York, 11/22/2002 Present Lew SM. "Tethered cord syndrome." Grand Rounds, Department of Pediatrics, Beth Israel Hospital-Singer Division, New York, New York, 09/04/2003 - Present Lew SM, “Pediatric Posterior Fossa Tumors.” Grand Rounds, Department of Pediatrics, Beth Israel Hospital Singer Division, New York City, New York, 04/08/2004 - Present Lew SM, Tethered cord syndrome.” Grand Rounds, Department of Pediatrics, All Saints Healthcare, Racine, Wisconsin, 12/14/2004 - Present Lew SM. "Concussion in the pediatric athlete". Children's Hospital of Wisconsin, Pediatric Sports Medicine Seminar, Milwaukee, Wisconsin, 05/22/2006 - Present Lew SM, “Initial management of pediatric closed head injury.” Children’s Hospital of Wisconsin, Pediatric Trauma Rounds, Milwaukee, Wisconsin, 06/06/2006 - Present Lew SM, “Cavernous malformations.” Medical College of Wisconsin, Neurosurgery Grand Rounds, Milwaukee, Wisconsin, 06/16/2006 - Present Lew SM. "Pediatric epilepsy surgery: update and overview." Pediatric Grand Rounds, Children's Hospital of

Wisconsin, 02/13/2009 - Present Lew SM. "Neurological monitoring in the ICU patient." Pediatric Critical Care Lecture Series, Children's Hospital of Wisconsin, 08/19/2009 - Present Lew SM. "Tethered cord syndrome - update and review." Pediatric Urology Conference, Children's Hospital of Wisconsin, 04/29/2010 - Present Regional Lew SM. "Pediatric Epilepsy Surgery." The Child with Special Needs Medical and Therapeutic Interventions Conference, Milwaukee, Wisconsin, 10/06/2006 - Present Lew SM. "Pediatric Epilepsy Surgery." Best Practices in Pediatrics, Fall 2008 Conference, Northbrook, IL, 09/20/2008 - Present Lew SM. "Craniocervical junction fixation." Medical College of Wisconsin Spine Course, 05/15/2010 Present National Lew SM. "Spinal Axis Trauma - Pediatric occipitocervical trauma". Panelist, Association of Neurological Surgeons Annual Meeting, Philadelphia, 05/03/2009 - Present Lew SM. "Spinal Axis Trauma - Pediatric occipitocervical trauma". Panelist, Association of Neurological Surgeons Annual Meeting, San Diego, CA, 05/06/2009 - Present Lew SM. "Pediatric Epilepsy Surgery - an update and review". Madi's Fund Invited Lectureship, University of Vermont College of Medicine, 06/03/2010 - Present International Lew SM. "Spine anatomy - general principles and clinical applications." Khon Kaen University, School of Medicine, Khon Kaen, Thailand, 11/15/2002 - Present

PEER REVIEWED WORKSHOPS/PRESENTATIONS: Regional Lew SM, Mehalic TF, “Transforaminal Percutaneous Endoscopic Discectomy in the Treatment of Far Lateral and Foraminal Lumbar Disc Herniations.”, New England Neurosurgical Society, Hanover, New Hampshire, 03/03/2000 - Present Khoshyomn S, Lew SM, Penar PL, “Synergistic antiproliferative action of genistein and cisplatin on growth inhibition and cytotoxicity of humanmedulloblastomas cells.”, New England Neurosurgical Society, Boston, Massachussetts, 06/16/2000 - Present Florman JE, Gross CE, Lew SM, “Postlaminectomy deformity: the role of the laminae.", New England Neurosurgical Society, Woods Hole, Massachussetts, 09/22/2000 - Present National Lew SM, Brummett R, Guitjens S, “Effect of Nonsteroidal Anti-Inflammatory Drugs on Auditory Brainstem Thresholds in Chinchillas." American Academy of Otolaryngology - Head and Neck Surgery, 1993 Annual Meeting, Minneapolis, Minnesota, 11/22/1993 - Present Lew SM, Gross CE, Bednar MM, Russell SJ, Fuller SP, Ellenberger CL, Howard D, “Complement Depletion Does Not Reduce Brain Injury in a Rabbit Model of Thromboembolic Stroke.”, New England Neurosurgical Society, Boston, Massachusetts, 06/06/1998 - Present Gruber A, Roessler K, Dietrich W, Lew SM, Czech T, Richling B, Ungersboeck K, “Evaluation of Endothelin Concentrations After Aneurysmal Subarachnoid Hemorrhage." Congress of Neurological Surgeon, 49th Annual Meeting, Boston, Massachusetts, 11/02/1999 - Present Lew SM, Fagone K, Mehalic TF, “Transforaminal percutaneous endoscopic Discectomy in the treatment of far lateral and foraminal lumbar disc herniations.", Congress of Neurological Surgeons, 50th Annual Meeting, San Antonio, Texas, 09/26/2000 - Present Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL, “Synergistic antiproliferative action of genistein and cisplatin on growth inhibition and cytotoxicity of human medulloblastomas", Annual Meeting of AANS/CNS Section on Pediatric Neurological Surgery, San Diego, California, 12/06/2000 12/09/2000 Krakovitz PR, Manske GC, Khoshyomn S, Sofferman RA, Lew SM, “Genistein enhances growth inhibition and cytotoxicity of actinomycin-D in pediatric rhabdomyosarcoma cells”, Annual Meeting of

AANS/CNS Section on Pediatric Neurological Surgery, New York, NY, 11/28/2001 - Present Krakovitz PR, Manske GC, Khoshyomn S, Sofferman RA, Lew SM, “Genistein enhances growth inhibition and cytotoxicity of actinomycin-D in pediatric rhabdomyosarcoma cells”, Annual meeting of American Society of Pediatric Otolaryngology, Scottsdale, AZ, 2001 - Present Bisson E, Lew SM, Horgan MA, “Vestibular schwannoma surgery: a historical perspective.”, North American Skull Base Society Annual Meeting, San Diego, CA, 02/16/2002 - Present Lew SM, Goumnerova LC, “Tectal gliomas – prognosis and evolution of management.”, Annual Meeting of the American Academy of Neurological Surgeons, Chicago, IL, 04/10/2002 - Present Florman JE, Lew SM, Tranmer BI, Horgan MA, “Pressure equalization tube syringosubarachnoid shunt: Technical note.", Annual Meeting of the American Association of Neurological Surgeons, 04/2003 Present Florman JE, Ozgur BM, Lew SM, Gross CE, “Hemilaminectomy alters strain across the compressed vertebral body.”, Annual Meeting of the American Association of Neurological Surgeons, 04/2003 - Present Lew SM, Abbott R, “Endoscopic management of quadrigeminal plate arachnoid cysts." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Salt Lake City, Utah, 12/02/2003 - 12/05/2003 Lew SM, Morgan JN, Psaty E, Lefton DR, Allen JC, Abbott R, “Cumulative incidence of radiation-induced lesions of magnetic susceptibility in children with medulloblastomas.", AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, 12/10/2004 - Present Lew SM, Pintar FA, Yoganandan N, Muszynski CA, Kaufman BA, “Case presentations from the Wisconsin CIREN program”, Rachidian Society Annual Meeting, Kona, Hawaii, 02/28/2005 - Present Koop JI, Heffelfinger AK, Kaufman BA, Lew SM, “Compensated hydrocephalus in preschoolers: neuropsychological and clinical outcomes.”, 34th Annual International Neuropsychological Society Meeting, Boston, Massachusetts, 02/01/2006 - Present Lew SM, Mueller W, Zupanc M, Schwabe M, Muszynski CA, Kaufman BA, “Combined corpus callosotomy and subdural electrode placement for both diagnostic and therapeutic management of epilepsy.", Rachidian Society Annual Meeting, Kona, Hawaii, 02/06/2006 - Present Muszynski CA, Lew SM, Kaufman BA, “Pediatric spinal intradural arachnoid cysts.", Rachidian Society Annual Meeting, Kona, Hawaii, 02/06/2006 - Present Lew SM, Miller ML, Muszynski CA, Kaufman BA, “Cerebrospinal fluid diversion during long-term invasive electroencephalography monitoring”, AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Denver, Colorado, 11/28/2006 - 12/01/2006 Lew SM, Zupanc ML, Roell-Werner R, Schwabe MJ, Mueller W, “Epilepsy surgery outcome in 83 pediatric patients - the Children's Hospital of Wisconsin Experience", AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Denver, Colorado, 11/28/2006 - 12/01/2006 Zupanc ML, Santos Rubio E, Roell-Werner R, Schwabe MJ, Mueller W, Lew SM, "Epilepsy surgery outcome - quality of life and seizure control - at Children's Hospital of Wisconsin", Annual Meetings of the American Epilepsy Society and Canadian League Against Epilepsy, San Diego, California, 12/02/2006 - Present Lew SM "Cervical spine instrumentation in the pediatric population." Rachidian Society Annual Meeting, Kona, Hawaii, 02/07/2007 - Present Marcuccilli CJ, Elsen FP, Lew SM, “Human neocortical intrinsic bursting neurons have persistent sodium dependent bursting properties.", Society for Neuroscience Annual Meeting, San Diego, California, 11/04/2007 - Present Tryba AK, Lew SM, Marcuccilli CJ "Brain derived neurotrophic factor enhances human and mouse neocortical rhythmicity." Society for Neuroscience Annual Meeting, San Diego, California, 11/04/2007 - Present Marcuccilli CJ, Elsen FP, Lew SM, Tryba AK, “Role of persistent sodium dependent intrinsic bursting neurons in human neocortical rhythmicity.”, American Epilepsy Society Annual Meeting, Philadelphia, PA, (Selected for Investigators’ Workshop Poster Session for outstanding abstracts on topics related to basic science and research), 12/02/2007 - Present Tryba AK, Lew SM, Marcuccilli CJ "Human and mouse neocortical rhythmicity is enhanced by Brain derived neurotrophic factor (BDNF)." American Epilepsy Society Annual Meeting, Philadelphia, Pennsylvania, 12/02/2007 - Present Tryba AK, Chevalier M, Lew SM, Marcuccilli CJ "Brain derived neurotrophic factor enhances human and mouse neocortical and mouse hippocampal rhythmicity." Society for Neuroscience Annual Meeting, Washington DC, 11/19/2008 - Present Matthews A, Kaufman B, Lew SM, Zwienenberg-Lee, M, “Using non-penetrating clips for dural closure in

pediatric spinal surgeries.", AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane Washington, 12/04/2008 - Present Lin JS, Lew SM, Mueller WM, Zupanc ML, “Corpus callosotomy in multistage epilepsy surgery in the pediatric population.", AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane, Washington, 12/04/2008 - Present Harter D, Sacco D, Pincus D, Brockmeyer D "Fusion rates following rigid internal fixation of the occiput to C2 are equivalent with or without C1 instrumentation." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane, Washington, 12/05/2008 - Present Tryba AK, Chevalier M, Lew SM, Marcuccilli CJ, “Brain derived neurotrophic factor enhances rhythmicity in human and mouse neocortical and mouse hippocampal networks”, American Epilepsy Society Annual Meeting, Seattle, WA, (Selected for Investigators’ Workshop Poster Session for outstanding abstracts on topics related to basic science and research), 12/07/2008 - Present Zupanc ML, Lin J, Lew SM, Schwabe M, Marcuccilli CJ, O'Connor SE, Sharif U, Hecox K, Roell-Werner R, Chico MS, Eggener K "Corpus callosotomy and focal resection in multistage epilepsy surgery in intractable pediatric epilepsy population." American Epilepsy Society Annual Meeting, Seattle, Washington, 12/07/2008 - Present Basheer A, Lew SM "Giant posterior fossa cavernomas in infants with familial cerebral cavernomatosis - the case for early screening." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Boston, Massachussetts, 12/01/2009 - Present Seiler F, Lew SM "Aqueductal stenosis presenting as isolated tremor: case report and review of the literature." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Boston, Massachussetts, 12/01/2009 - Present Lew SM, Laviolette P, Rand S, Raghavan M, Mueller W "Three-Dimensional (3D) visualization of intracranial electrode placement in pediatric epilepsy surgery." American Society of Pediatric Neurosurgeons Annual Meeting, Grand Cayman, 01/29/2010 - Present Klimo P, Matthews A, Lew SM, Zweinenberg-Lee, M, Kaufman BA "Mini-craniotomy versus burr hole for evacuation of chronic subdural collections in infants." AAANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Cleveland, Ohio, 12/02/2010 - Present International Tryba AK, Elsen FP, Lew SM, Marcuccilli CJ, “Persistent sodium dependent intrinsic bursting neurons in human neocortical rhythmicity." Eighth International Congress of Neuroethology, Vancouver, Canada, 07/26/2007 - Present Tryba AK, Lew SM, Marcuccilli CJ. "Brain derived neurotrophic factor enhances human and mouse neocortical rhythmicity." Eighth International Congress of Neuroethology, Vancouver, Canada, 07/26/2007 - Present

COMMITTEE SERVICE: Medical College 07/2005 - Present Member, Faculty Council, MCW

MEDICAL COLLEGE TEACHING ACTIVITIES: Community/Lay Public 05/2006 Presenter, Pediatric Sports Medicine Seminar, Children’s Hospital Of Wisconsin 10/2006 Presenter, Child With Special Needs Conference, Milwaukee, WI Medical Student Education 09/2007 - Present Mentor, Clinical Continuum Program 08/2009 - Present Mentor, GURU Program Resident and Fellow Education 09/2004 - Present Clinical Instructor, Neurosurgery 05/2010 Practical lab instructor/lecturer, MCW Spine Course Continuing Medical Education

09/2004 - Present Instructor, Advanced Trauma Life Support 06/2006 Presenter, Grand Rounds, Pediatric Trauma Conference, Children’s Hospital Of Wisconsin 06/2006 Presenter, Grand Rounds, Department of Neurosurgery 02/2009 Presenter, Grand Rounds, Department of Pediatrics 08/2009 Presenter, Pediatric Critical Care Series, Department of Pediatrics 04/2010 Presenter, Pediatric Conference, Department of Urology

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: Medical Students Joshua Larson (Class of 2011), MCW, 09/2007 - 06/2008 Student Mentor (M-1 Clinical Continuum Program) Jeffrey Kao (Class of 2009), MCW, 03/2008 - 07/2009 Clinical research Francis Seiler (Class of 2012), MCW, 10/2008 - Present Student Mentor (M-1 Clinical Continuum Program), clinical research Azam Basheer (Class of 2010), MCW, 02/2009 - 11/2009 Clinical research Tianyi Niu (Class of 2012), MCW, 02/2009 - Present Student Mentor Mohammad-Ali Jazayeri (Class of 2013), MCW, 10/2009 - Present Student Mentor, clinical research Craig Tork (Class of 2013), MCW, 10/2009 - Present Student Mentor (M-1 Clinical Continuum Program) Residents Matthew Miller MD, MCW, 06/2007 - 12/2007 Clinical Research Jessica Lin MD, MCW, 08/2008 - 02/2010 Clinical Research Faculty Marike Zwienenberg-Lee MD, MCW, 09/2007 - 06/2010 Pediatric epilepsy surgery

PROGRAMMATIC DEVELOPMENTS:

Clinical Programs 07/2008 - Present Program Director, Neurosurgery Epilepsy, Children’s Hospital of Wisconsin, Milwaukee, WI

COMMUNITY SERVICE ACTIVITIES: 11/2002 - 12/2002 Volunteer Neurosurgeon, Foundation for International Education in Neurological Surgery, Sringarind Hospital, Khon Kaen University, Khon Kaen, Thailand

BIBLIOGRAPHY Refereed Journal Publications/Original Papers 1. Gross CE, Bednar MM, Lew SM, Florman JE, Kohut JJ: Preoperative volume expansion improves tolerance to carotid artery cross-clamping during endarterectomy. Neurosurgery, 43:222-228, 1998. 2. Lew SM, Gross CE, Bednar MM, Russell SJ, Fuller SP, Ellenberger CL, Howard D: Complement depletion does not reduce brain injury in a rabbit model of thromboembolic stroke. Brain Res Bull, 48:325-331, 1999. 3. Lew SM, Frumiento C, Wald SL: Pediatric blunt carotid injury: A review of the National Pediatric Trauma Registry. Pediatr Neurosurg 30:239-244, 1999. 4. Khoshyomn S, Lew SM, DeMattia J, Singer EB, Penar PL: Brain tumor invasion rate measured in vitro does not correlate with Ki-67 expression. J Neurooncol 45:111-6, 1999. 5. Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL: Synergistic Antiproliferative Action of Genistein and Cisplatin on Growth Inhibition and Cytotoxity of Human Medulloblastoma Cells. Pediatr Neurosurg 33:123-131, 2000. 6. Khoshyomn S, Lew SM, Braff SP: Sugarcoating - Leptomeningeal spread of medulloblastoma. Pediatr

Neurosurg 33:333, 2000. 7. Lew SM, Mehalic TF, Fagone KL: Transforaminal percutaneous endoscopic discectomy in the treatment of far lateral and foraminal lumbar disc herniations. J Neurosurg (Spine 2) 94:216-220, 2001. 8. Lew SM, Khoshyomn S, Hamill RW, Tranmer BI: Cavernous malformation of the facial colliculus. Neurology 58:79-84, 2002. 9. Khoshyomn S, Lew SM, Wilson JT: Aneurysmal bone cyst of the cervical spine. Pediatr Neurosurg 37:48-49, 2002. 10. Ozgur BM, Florman JE, Lew SM, Taylor WP, Gross C: Laminectomy contributes to cervical spine deformity demonstrated by holographic interferometry. J Spinal Disord Tech 16(1):51-54, 2003. 11. Lew SM: Temporary central hypoventilation following craniopharyngioma resection. J Ped Neurology 2(3):167-170, 2004. 12. Lew SM, Psaty EL, Abbott R: An unusual cause of overdose following baclofen pump implantation. Neurosurg 56:624, 2005. 13. Lew SM, Morgan JN, Psaty E, Lefton DR, Allen JC, Abbott R: Cumulative incidence of radiation-induced cavernomas in long term survivors of medulloblastoma. J Neurosurg (2 Suppl):103-107, 2006. 14. Lew SM, Kothbauer KF: Tethered cord syndrome: an updated review. Pediatr Neurosurg 43:236-248, 2007. 15. Miller ML, Kaufman BA, Lew SM: Modified osteoplastic orbitozygomatic craniotomy in the pediatric population. Child Nervous System 24:845-850, 2008. 16. Sanchez A, Stuth EA, Lew SM: Postoperative upper extremity hemiplegia in a toddler following general anesthesia for drainage of a subgaleal fluid collection. Pediatric Anesthesia 18: 564-566, 2008. 17. Zupanc ML, Dos Santos Rubio E, Werner R, Schwabe M, Mueller W, Lew SM, Marcuccilli C, O'Connor S, Hecox K: Epilepsy Surgery Outcomes - Quality of life and seizure control. Pediatr Neurol 42(1):12-20, 2010. 18. Hankinson TC, Avellino A, Harter D, Lew SM, Jea A, Pincus D, Proctor M, Rodriguez L, Sacco D, Spinks T, Brockmeyer DL, Anderson RCE: Fusion rates following rigid internal fixation of the occiput to C2 are equivalent with or without C1 instrumentation. J Neurosurg 5(4): 380-384, 2010. 19. Lew SM: Giant posterior fossa cavernous malformations in two infants with familial cerebral cavernomatosis - the case for early screening. Neurosurg Focus 29 (3):E18, 2010. 20. Kaufman BA, Matthews AE, Zweinenberg-Lee M, Lew SM: Dural closure with titanium non-penetrating clips in pediatric neurosurgery. J Neurosurg Pediatr 6: 359-363, 2010. 21. Marcuccilli CJ, Tryba AK, van Drongelen W, Koch H, Viemari JC, Pena-Ortega F, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM: Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol 27(6):387-397, 2010. 22. Seiler A, Lew SM: Aqueductal stenosis presenting as isolated tremor: case report and review of the literature. Pediatric Neurosurgery 46(5):392-395, 2010. 23. Amlie-Lefond C, Zaidat OO, Lew SM: Moyamoya syndrome in early infancy: case report and review of the literature. Pediatr Neurol 44:299-302, 2011. 24. Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML: Corpus callosotomy in multistage epilepsy surgery in the pediatric population. J Neurosurg Pediatr 7:189-200, 2011. 25. Laviolette P, Rand S, Ellingson M, Raghavan M, Lew SM, Schmainda K, Mueller W: 3D visualization of subdural electrode shift as measured at craniotomy reopening. Epilepsy Research 94(1-2):102-9, 2011. Books, Chapters, and Reviews 1. Lew SM, Kaufman BA: "Neural and vertebral column embryogenesis." Surgery of the Pediatric Spine. Kim, Daniel; Betz, Randall; Huhn, Stephen; Newton, Peter (eds.), Thieme Medical Publishers, New York, 2008. Editorials, Letters to Editor, Other 1. Florman JE, Lew SM. "Endoscopic septostomy for headache." J Neurosurg Pediatr 5(5):535, 2010. Abstracts 1. Lew SM, Brummett R, Guitjens S. "Effect of nonsteroidal anti-inflammatory drugs on auditory brainstem thresholds in chinchillas." Proceedings of the Annual Meeting of the American Academy of Otolaryngology - Head and Neck Surgery, 1993. 2. Lew SM, Gross CE, Bednar MM, Russell SJ, Fuller SP, Ellenberger CL, Howard D. "Complement Depletion Does Not Reduce Brain Injury in a Rabbit Model of Thromboembolic Stroke." New England

Neurosurgical Society, Summer Meeting, Scientific Session. June, 1998. 3. Lew SM, Mehalic TF. "Transforaminal percutaneous endoscopic discectomy in the treatment of far lateral and foraminal lumbar disc herniations." New England Neurosurgical Society, Spring Meeting, Scientific Session, March, 2000. 4. Khoshyomn S, Lew SM, Penar PL: "Synergistic action of genestein and cisplatin on growth inhibition and cytotoxicity of human medulloblastomas cells." New England Neurosurgical Society, Summer Meeting, Scientific Session, June, 2000. 5. Florman JE, Gross CE, Lew SM. "Postlaminectomy deformity: the role of the laminae." New England Neurosurgical Society, Fall Meeting, Scientific Session, September, 2000. 6. Lew SM, Fagone K, Mehalic TF. "Transforaminal Percutaneous Endoscopic Discectomy in the Treatment of Far Lateral and Foraminal Lumbar Disc Herniations." Congress of Neurological Surgeons, 50th Annual Meeting, September, 2000. 7. Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL. "Synergistic antiproliferative action of genistein and cisplatin on growth inhibition and cytotoxicity of human medulloblastomas." Annual Meeting of AANS/CNS Section on Pediatric Neurological Surgery, December, 2000. 8. Lew SM, Goumnerova LC. "Pediatric tectal tumors: the Children's Hospital at Boston experience." Annual Meeting of AANS/CNS Section on Pediatric Neurological Surgery, December, 2001. 9. Bisson E, Lew SM, Horgan MA. "Vestibular schwannoma surgery: a historical perspective." North American Skull Base Society Annual Meeting, 2002. 10. Lew SM, Goumnerova LC. "Tectal gliomas - prognosis and evolution of management." Scientific Program, Annual Meeting of the American Association of Neurological Surgeons, 2002. 11. Florman JE, Lew SM, Tranmer BI, Horgan MA. "Pressure equalization tube syringosubarachnoid shunt: Technical note." Annual Meeting of the American Association of Neurological Surgeons, April, 2003. 12. Florman JE, Ozgur BM, Lew SM, Gross CE. "Hemilaminectomy alters strain across the compressed vertebral body." Annual Meeting of the American Association of Neurological Surgeons, April, 2003. 13. Lew SM, Abbott R. "Endoscopic management of quadrigeminal plate arachnoid cysts." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Salt Lake City, Utah, December 2-5, 2003. 14. Lew SM, Morgan JN, Psaty E, Lefton DR, Allen JC, Abbott R. "Cumulative incidence of radiation-induced lesions of magnetic susceptibility in children with medulloblastomas." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, December 10, 2004. 15. Lew SM, Pintar FA, Yoganandan N, Muszynski CA, Kaufman BA. "Case presentations from the Wisconsin CIREN program." Rachidian Society Annual Meeting, Kona, Hawaii, February 28, 2005. 16. Koop JI, Heffelfinger AK, Kaufman BA, Lew SM. "Compensated hydrocephalus in preschoolers: neuropsychological and clinical outcomes." 34th Annual International Neuropsychological Society Meeting, Boston, Massachusetts, Feb 1, 2006. 17. Muszynski CA, Lew SM, Kaufman BA. "Pediatric spinal intradural arachnoid cysts." Rachidian Society Annual Meeting, Kona, Hawaii, February 6, 2006. 18. Lew SM, Mueller W, Zupanc M, Schwabe M, Muszynski CA, Kaufman BA. "Combined corpus callosotomy and subdural electrode placement for both diagnostic and therapeutic management of epilepsy." Rachidian Society Annual Meeting, Kona, Hawaii, February 6, 2006. 19. Lew SM, Miller ML, Muszynski CA, Kaufman BA. "Modified osteoplastic orbitozygomatic craniotomy in the pediatric population." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Denver, Colorado November 28 - December 1, 2006. 20. Lew SM, Miller ML, Muszynski CA, Kaufman BA. "Cerebrospinal fluid diversion during long-term invasive electroencephalography monitoring." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Denver, Colorado November 28 - December 1, 2006. 21. Lew SM, Zupanc ML, Roell-Werner R, Schwabe MJ, Mueller W. "Epilepsy surgery outcome in 83 pediatric patients - the Children's Hospital of Wisconsin Experience." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Denver, Colorado November 28 - December 1, 2006. 22. Zupanc ML, Santos Rubio E, Roell-Werner R, Schwabe MJ, Mueller W, Lew SM. "Epilepsy surgery outcome - quality of life and seizure control - at Children's Hospital of Wisconsin." Annual Meetings of the American Epilepsy Society and Canadian League Against Epilepsy, San Diego, California, December 2, 2006. 23. Lew SM. "Cervical spine instrumentation in the pediatric population." Rachidian Society Annual Meeting, Kona, Hawaii, February, 7, 2007. 24. Tryba AK, Elsen FP, Lew SM, Marcuccilli CJ. "Persistent sodium dependent intrinsic bursting neurons in human neocortical rhythmicity." Eighth International Congress of Neuroethology, Vancouver, Canada,

July 26, 2007. 25. Tryba AK, Lew SM, Marcuccilli CJ. "Brain derived neurotrophic factor enhances human and mouse neocortical rhythmicity." Eighth International Congress of Neuroethology, Vancouver, Canada, July 26, 2007. 26. Tryba AK, Lew SM, Marcuccilli CJ. "Brain derived neurotrophic factor enhances human and mouse neocortical rhythmicity." Society for Neuroscience Annual Meeting, San Diego, California, November 4, 2007. 27. Marcuccilli CJ, Elsen FP, Lew SM., Tryba AK. "Human neocortical intrinsic bursting neurons have persistent sodium dependent bursting properties." Society for Neuroscience Annual Meeting, San Diego, California, November 4, 2007. 28. Tryba AK, Lew SM, Marcuccilli CJ. "Human and mouse neocortical rhythmicity is enhanced by Brain derived neurotrophic factor (BDNF)." American Epilepsy Society Annual Meeting, Philadelphia, Pennsylvania, December 2, 2007. 29. Marcuccilli CJ, Elsen FP, Lew SM, Tryba AK. "Role of persistent sodium dependent intrinsic bursting neurons in human neocortical rhythmicity." American Epilepsy Society Annual Meeting, Philadelphia, Pennsylvania, December 2, 2007. (Selected for Investigators' Workshop Poster Session for outstanding abstracts on topics related to basic science and research.) 30. Marcuccilli CJ, Tryba A, Lew SM, Kock H, Pena F, Viemari JC, van Drongelen W, Kohrman M, Frim DM, Ramirez J. "A comparison of in vitro electrophysiologic differences between focal and parafocal tissue resected from pediatric epilepsy patients: moving towards a greater understanding of the nature of epilepsy." International Society for Pediatric Neurological Surgery Annual Meeting, Cape Town, South Africa, October 13, 2008. 31. Tryba AK, Chevalier M, Lew SM, Marcuccilli CJ. "Brain derived neurotrophic factor enhances human and mouse neocortical and mouse hippocampal rhythmicity." Society for Neuroscience Annual Meeting, Washington DC, November 19, 2008. 32. Matthews A, Kaufman B, Lew SM, Zwienenberg-Lee, M. "Using non-penetrating clips for dural closure in pediatric spinal surgeries." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane, Washington, December 4, 2008. 33. Lin JS, Lew SM, Mueller WM, Zupanc ML. "Corpus callosotomy in multistage epilepsy surgery in the pediatric population." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane, Washington, December 4, 2008. 34. Anderson R, Hankinson T, Spinks T, Jea A, Proctor M, Lew SM, Rodriguez L, Harter D, Sacco D, Pincus D, Brockmeyer D. "Fusion rates following rigid internal fixation of the occiput to C2 are equivalent with or without C1 instrumentation." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Spokane, Washington, December 5, 2008. 35. Zupanc ML, Lin J, Lew SM, Schwabe M, Marcuccilli CJ, O'Connor SE, Sharif U, Hecox K, Roell-Werner R, Chico MS, Eggener K. "Corpus callosotomy and focal resection in multistage epilepsy surgery in intractable pediatric epilepsy population." American Epilepsy Society Annual Meeting, Seattle, Washington, December 7, 2008. 36. Tryba AK, Chevalier M, Lew SM, Marcuccilli CJ. "Brain derived neurotrophic factor enhances rhythmicity in human and mouse neocortical and mouse hippocampal networks." American Epilepsy Society Annual Meeting, Seattle, Washington, December 7, 2008. (Selected for Investigators' Workshop Poster Session for outstanding abstracts on topics related to basic science and research.) 37. Basheer A, Lew SM. "Giant posterior fossa cavernomas in infants with familial cerebral cavernomatosis the case for early screening." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Boston, Massachussetts, December 1, 2009. 38. Seiler F, Lew SM. "Aqueductal stenosis presenting as isolated tremor: case report and review of the literature." AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Boston, Massachussetts, December 1, 2009. 39. Lew SM, Laviolette P, Rand S, Raghavan M, Mueller W. "Three-Dimensional (3D) visualization of intracranial electrode placement in pediatric epilepsy surgery." Annual Meeting of the American Society of Pediatric Neurosurgeons, Jan 28, 2010. J Neurosurg: Ped 5: A323. 40. Klimo P, Matthews A, Lew SM, Zweinenberg-Lee, M, Kaufman BA. "Mini-craniotomy versus burr hole for evacuation of chronic subdural collections in infants." AAANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, Cleveland, Ohio, December 2, 2010. 41. Lew SM, Matthews AE, Mueller WM, Zupanc ML. "Forty consecutive hemispherectomies: evolution of technique, outcomes, complications, and lessons learned." Annual Meeting of the American Society of

Pediatric Neurosurgeons, February 2, 2011, J Neurosurg: Ped 7: A322. Database, Video, or Other Research/Clinical Contributions 1. Lew SM, Zupanc ML. "Epilepsy surgery: not a last resort." Pediatric Rounds, Children's Hospital and Health System, Spring 2008.

Powered by TCPDF (www.tcpdf.org)