ADVANCED ANALYTICAL TECHNOLOGIES, INC. Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% SECTION 1: Identification 1.1

Product identifier Product name

1.2

PK-CS60 24 point Cosolvent pKa Buffer 60%

Recommended use of the chemical and restrictions on use For Research and Development/Experimental Use Only

1.3

1.4

Supplier’s details Name Address

Advanced Analytical Technologies, Inc. 2450 SE Oak Tree Ct. Suite 101 Ankeny, IA 50021 USA

Telephone

515-296-6600

Emergency phone number(s) 515-296-6600

SECTION 2: Hazard identification 2.1

Classification of the substance or mixture GHS classification in accordance with OSHA (29 CFR 1910.1200) - Flammable liquids (chapter 2.6), Cat. 2 - Acute toxicity, oral (chapter 3.1), Cat. 3 - Acute toxicity, dermal (chapter 3.1), Cat. 3 - Acute toxicity, inhalation (chapter 3.1), Cat. 3 - Specific target organ toxicity, single exposure (chapter 3.8), Cat. 1 - Specific target organ toxicity, repeated exposure (chapter 3.9), Cat. 1 - Eye damage/irritation (chapter 3.3), Cat. 1 - Skin corrosion/irritation (chapter 3.2), Cat. 1C

2.2

GHS label elements, including precautionary statements Pictogram

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Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60%

Signal word

Danger

Hazard statement(s) H225 H301 H311 H331 H335 H336 H370 H372 H314

Highly flammable liquid and vapor Toxic if swallowed Toxic in contact with skin Toxic if inhaled May cause respiratory irritation May cause drowsiness or dizziness Causes damage to organs Causes damage to organs through prolonged or repeated exposure Causes severe skin burns and eye damage

Precautionary statement(s) P264 P270 P280 P271 P260 P210 P233 P240 P241 P242 P243 P235 P308+P311 P304+P340 P305+P351+P338 P310 P303+P361+P353 P363 P312 P301+P310 P330 P370+P378 P405 P403+P233 P501 2.3

Wash face, hands and any exposed skin thoroughly after handling. Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. Use only outdoors or in a well-ventilated area. Do not breathe dust/fume/gas/mist/vapours/spray. Keep away from heat, hot surfaces, sparks, open flames, and other ignition sources. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Keep cool. IF exposed or concerned: Call a POISON CENTER/doctor/physician. IF INHALED: Remove person to fresh air and keep comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor/physician. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash contaminated clothing before reuse. Call a POISON CENTER/doctor/physician if you feel unwell. IF SWALLOWED: Immediately call a POISON CENTER/doctor/physician. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam to extinguish. Store locked up. Store in a well ventilated place. Keep container tightly closed. Dispose of contents/container to an approved waste disposal plant.

Other hazards which do not result in classification Poison, may be fatal or cause blindness if swallowed. Vapor harmful. Cannot be made non-poisonous. WARNING! This product contains a chemical known in the State of California to cause birth defects or other reproductive harm.

SECTION 3: Composition/information on ingredients 3.1

Substances

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Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% Hazardous components 1. WATER Concentration

> 39.5 % (Weight)*

Other names / synonyms CAS no.

DIHYDROGEN OXIDE; HYDROGEN OXIDE 7732-18-5

2. Methanol Concentration

60 % (Weight)

Other names / synonyms

EC no. CAS no. Index no.

CARBINOL; COLONIAL SPIRIT; COLUMBIAN SPIRIT; meoh; METHANOL; METHYL ALCOHOL; METHYL HYDROXIDE; METHYLALCOHOL; METHYLOL; MONOHYDROXYMETHANE; NA 1230 (DOT); PYROXYLIC SPIRIT; RCRA WASTE NUMBER U154; UN 1230 (DOT); WOOD ALCOHOL; WOOD NAPHTHA; WOOD SPIRIT 200-659-6 67-56-1 603-001-00-X

3. Proprietary buffer components* Concentration < 0.5 % (Weight)* Trade secret statement (OSHA 1910.1200(i)) *The specific chemical identity and/or exact percentage (concentration) of this composition has been withheld as a trade secret.

SECTION 4: First-aid measures 4.1

4.2

Description of necessary first-aid measures General advice

Immediate medical attention is required. Show this safety data sheet to the doctor in attendance.

If inhaled

Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with a respiratory medical device. Immediate medical attention is required.

In case of skin contact

Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

In case of eye contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.

If swallowed

Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms/effects, acute and delayed Breathing difficulties. Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting: May cause blindness: Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.

SECTION 5: Fire-fighting measures Version: 1.0, Date of issue: 2015-05-27, p. 3 of 9

Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% 5.1

Suitable extinguishing media CO2, dry chemical, dry sand, alcohol-resistant foam. Use water spray to cool unopened containers. Cool closed containers exposed to fire with water spray. Water may be ineffective.

5.2

Specific hazards arising from the chemical Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Containers may explode when heated. Vapors may form explosive mixtures with air.

5.3

Special protective actions for fire-fighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

SECTION 6: Accidental release measures 6.1

Personal precautions, protective equipment and emergency procedures Remove all sources of ignition. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Use personal protective equipment. Ensure adequate ventilation. Take precautionary measures against static discharges.

6.2

Environmental precautions Should not be released into the environment.

6.3

Methods and materials for containment and cleaning up Remove all sources of ignition. Soak up with inert absorbent material. Take precautionary measures against static discharges. Keep in suitable, closed containers for disposal. Use spark-proof tools and explosion-proof equipment.

SECTION 7: Handling and storage 7.1

Precautions for safe handling Wear personal protective equipment. Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing. Use only non-sparking tools. Use explosion-proof equipment.

7.2

Conditions for safe storage, including any incompatibilities Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from open flames, hot surfaces and sources of ignition. Flammables area.

SECTION 8: Exposure controls/personal protection 8.1

Control parameters 1. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) PEL-TWA: 200 ppm (ACGIH) 2. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) Headache, Nausea, Dizziness, Eye damage Substances for which there is a Biological Exposure Index or Indices (see BEI® section) Danger of cutaneous absorption 3. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) STEL: 250 ppm (ACGIH) 4. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) PEL-TWA: 200 ppm, 325 mg/m3 (NIOSH) 5. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) Version: 1.0, Date of issue: 2015-05-27, p. 4 of 9

Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% Potential for dermal absorption 6. METHYL ALCOHOL (CAS: 67-56-1 EC: 200-659-6) PEL-TWA: 200 ppm, 260 mg/m3 (OSHA) USA. Occupational Exposure Limits (OSHA) - Table Z-1 Limits for Air Contaminants 7. Methyl alcohol (CAS: 67-56-1) PEL (Inhalation): 200 ppm (OSHA) OSHA Annotated Table Z-1, www.osha.gov 8. Methyl alcohol (CAS: 67-56-1) PEL (Inhalation): 260 mg/m3 (OSHA) OSHA Annotated Table Z-1, www.osha.gov 9. Methyl alcohol (CAS: 67-56-1) PEL (Inhalation): 200 ppm, (ST) 250 ppm, (C) 1000 ppm (Cal/OSHA) OSHA Annotated Table Z-1, www.osha.gov 10. Methyl alcohol (CAS: 67-56-1) REL (Inhalation): 200 ppm, (ST) 250 ppm (NIOSH) OSHA Annotated Table Z-1, www.osha.gov 8.2

Appropriate engineering controls Use only under a chemical fume hood. Use explosion-proof electrical/ventilating/lighting/equipment. Ensure that eyewash stations and safety showers are close to the workstation location.

8.3

Individual protection measures, such as personal protective equipment (PPE) Eye/face protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

SECTION 9: Physical and chemical properties Information on basic physical and chemical properties Appearance/form Odor Odor threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Flammability (solid, gas) Upper/lower flammability limits Upper/lower explosive limits

Colorless liquid Alcohol-like No data available 2 -12 No data available No data available No data available No data available No data available No data available No data available Version: 1.0, Date of issue: 2015-05-27, p. 5 of 9

Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% Vapor pressure Vapor density Relative density Solubility(ies) Partition coefficient: n-octanol/water Auto-ignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties

No data available No data available No data available No data available No data available No data available No data available No data available No data available No data available

SECTION 10: Stability and reactivity 10.1 Reactivity None known, based on information available 10.2 Chemical stability Stable under normal conditions. 10.3 Possibility of hazardous reactions None under normal processing. 10.4 Conditions to avoid Incompatible products. Heat, flames and sparks. Keep away from open flames, hot surfaces and sources of ignition. 10.5 Incompatible materials Strong oxidizing agents, Strong acids, Acid anhydrides, Acid chlorides, Strong bases, Metals, Peroxides 10.6 Hazardous decomposition products Carbon monoxide (CO), Formaldehyde

SECTION 11: Toxicological information Information on toxicological effects Acute toxicity No data available Skin corrosion/irritation pH range: 2 - 12 Serious eye damage/irritation pH range: 2 - 12 Respiratory or skin sensitization No data available Germ cell mutagenicity No data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

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Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Reproductive toxicity No data available STOT-single exposure Respiratory system, Central nervous system (CNS), Optic nerve STOT-repeated exposure Kidney, Liver, Spleen, Blood, Respiratory system Aspiration hazard No data available

SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data available Bioaccumulative potential No data available Mobility in soil No data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted. Other adverse effects No data available

SECTION 13: Disposal considerations Disposal of the product Should not be released into the environment. Dispose of material in accordance with all federal, state, and local regulations. Disposal of contaminated packaging Dispose of as unused product.

SECTION 14: Transport information DOT (US) UN Number: UN1230 Version: 1.0, Date of issue: 2015-05-27, p. 7 of 9

Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% Class: 3 Packing Group: II Proper Shipping Name: METHANOL Reportable quantity (RQ): IMDG UN Number: UN1230 Class: 3 Packing Group: II Proper Shipping Name: METHANOL IATA UN Number: UN1230 Class: 3 Packing Group: II Proper Shipping Name: METHANOL

SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question SARA 302 Components The following components are subject to reporting levels established by SARA Title III, Section 302: Methyl alcohol 67-56-1 SARA 311/312 Hazards Fire Hazard, Acute Health Hazard, Chronic Health Hazard SARA 313 Components The following components are subject to reporting levels established by SARA Title III, Section 313: Methyl alcohol 67-56-1 Massachusetts Right To Know Components Methyl alcohol 67-56-1 New Jersey Right To Know Components Methyl alcohol 67-56-1 Pennsylvania Right To Know Components Methyl alcohol 67-56-1 California Prop. 65 Components WARNING: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

SECTION 16: Other information Revision date: May 28, 2015 This information provided concerning this Safety Data Sheet is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, expressed or implied, with respect to such information and we assume no liability resulting from its use. Users should make their own investigations to determining the suitability of the information for their particular purposes. This material is for R&D/experimental use only. In no event shall Advanced Analytical be liable for any claims,

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Safety Data Sheet PK-CS60 24 point Cosolvent pKa Buffer 60% losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, however arising, even if Advanced Analytical has been advised of the possibility of such damages.

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