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The San Diego Chemist American Chemical Society Volume 28, Number 10 WEBSITE

San Diego Section October 2016 NEWSLETTERS

EVENTS

CHEMPLOYMENT

Fats and Lipid Enzymes in Health and Disease 2016 Distinguished Scientist Award Banquet Edward A. Dennis

Distinguished Professor of Chemistry, Biochemistry and Pharmacology University of California, San Diego About the Lecture

The “omics” revolution began at the end of the 20th century with cloning of the human genome which has now evolved from proteomics to metabolomics -- the identification of all of the chemical metabolites in our body including nucleic acids, amino acids, sugars, and fats. But by far, the largest number of distinct chemicals in metabolism lies in the fats (or lipids), where over 40,000 distinct molecular species have been identified by the LIPID MAPS Consortium (http://www.lipidmaps.org/). Dr. Dennis’ lab has developed novel liquid chromatographic-mass spectrometric-based lipidomic techniques to identify and quantify the distinct molecular species of lipids in blood and other tissues during infection, including elucidating the dual role of aspirin in inhibiting production of pro-inflammatory prostaglandins, but also in enhancing production of anti-inflammatory “resolving” molecules. Lipid acting enzymes associate allosterically with membranes and extract the phospholipid substrate so as to release eicosanoid precursors, and potent/selective inhibitors as anti-inflammatory drugs can be visualized using molecular dynamics.

About the Speaker Dr. Dennis is Distinguished Professor in the Chemistry and Biochemistry Department and in the Pharmacology Department in the School of Medicine at UCSD. He received his B.A. from Yale and a Ph.D. from Harvard and was a postdoctoral fellow at Harvard Medical School prior to joining UCSD as an Assistant Professor of Chemistry in 1970. At UCSD he has served as Chair of the Department of Chemistry and Biochemistry, as Chair of the Faculty Academic Senate, and on the Board of Overseers. He has served as Visiting Professor at Harvard Medical School, Visiting Scientist at Brandeis University, Adjunct Professor at The Scripps Research Institute, Visiting Professor at the Collège de France, and Visiting Research Professor at Université Pierre et Marie Curie. Dr. Dennis’ career research focus has been on the mechanism of the enzyme phospholipase A2, signal transduction, inflammation, lipid metabolism, eicosanoid action, and lipidomics. He has authored over 380 research publications and patented numerous inventions. He is currently Editor-in-Chief of the Journal of Lipid Research and served as Director of the LIPID MAPS Consortium.

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Tony Bottone Award for Outstanding Service Ken Poggenburg, Councilor & Chair, Retired Chemists Committee

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Outstanding Committee Chair Award John Schindler, Co-Chair, San Diego Section Awards Committee

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Outstanding Chemistry Educator Award Joan Schellinger, Assistant Professor Department of Chemistry and Biochemistry, University of San Diego

DATE:

Thursday, October 13, 2016

TIME:

6:00 PM 6:30 PM 7:30 PM

PLACE:

The Ida and Cecil Green Faculty Club – UCSD, 9500 Gilman Drive, La Jolla For directions please see: http://facclub.ucsd.edu/mod_aboutus/Directions.aspx

PRICE:

$30.00 per dinner, $15.00 with student I.D.

No host bar Dinner Award lecture

Reservations required RSVP:

Monday, October 10, 2016

http://sandiegoacsedwarddennis2016.eventbrite.com/

CHAIR NOTES Dear Local Section Members, As we enter the final quarter of 2016 and the country is preparing to vote for our next president, we will also be holding our annual elections for ACS Local Section offices. Registered ACS members will receive an e-mail notification that will let you know when the polls are open. Your vote is crucial in electing the next officers of the San Diego Section of the ACS. The annual Awards Banquet will be held at the UCSD Faculty Club on Thursday, October 13th. This year we will be honoring our distinguished scientist, Dr. Edward A. Dennis, Professor of Chemistry, Biochemistry and Pharmacology at University of California, San Diego. His lecture is titled "Fats and Lipid Enzymes in Health and Disease". We will also honor some of our ACS Local Section volunteers: Ken Poggenburg has earned the Tony Buttone Award for Outstanding Service, John Schindler the Outstanding Committee Chair Award, and Joan Schellinger the Outstanding Chemistry Educator Award. If you would like to attend please register at: http://sandiegoacsedwarddennis2016.eventbrite.com/ Further events to look forward to include: • ChemExpo 2016 will occur at Miramar College on Saturday, October 22nd. The theme this year will be “Solving Mysteries Through Chemistry”. • Our Annual Holiday Party will be held at Sufi Mediterranean Cuisine Restaurant in Clairemont on Thursday, December 1st. For more information on all of this please see the current edition of the newsletter and check online at http://www.sandiegoacs.org. Finally, if you would like to become more involved in the ACS San Diego please join us at an Executive Committee meeting. The next one will be held on Thursday, October 6th. We welcome everyone who would like to attend. Cheers, Graeme Freestone 2016 Chair American Chemical Society – San Diego Section E-mail: [email protected] Web: www.sandiegoacs.org

FREE EVENT ANNOUNCEMENTS FOR NON-PROFIT ORGANIZATIONS! Does your non-profit organization have an upcoming event that might be of interest to members of the ACS – San Diego Section? If so, please send your announcement to our 2016 Chair, Graeme Freestone, at [email protected]. Once approved, Graeme will see that your announcement is published on our website (www.sandiegoacs.org) and, if received by the 23rd of the month before the event, in The San Diego Chemist newsletter. This is a free service of the ACS – San Diego Section. Take advantage of it!

ATTENTION ADVERTISERS Did you know that The San Diego Chemist is the only monthly e-newsletter that targets chemists and chemical engineers in San Diego and Imperial Counties? As soon as our newsletter is uploaded on www.sandiegoacs.org a separate notification is sent to the 2,500 members of the ACS-San Diego Section, each potential customers for your products and services! Quick turnaround: Ad copy submitted by the 23rd of each month will be published by the end of that month. For more information, please contact: Renate Valois, [email protected].

THE SAN DIEGO CHEMIST, the official newsletter of the San Diego Section of the American Chemical Society, published on a monthly basis, can be viewed at http://www.sandiegoacs.org/newsletter/. All contents are published at the discretion of the Section's Executive Committee. Events of interest to chemistry professionals in the community may be included in the events calendar as space permits and are subject to editing for brevity. Advertisements and announcements from the chemistry community are accepted at published rates. The deadline for items submitted is the 23rd of the month for publication by the end of that month. Advertisers: Ad prices as of January 1, 2015: Size (w x h) Number of Issues & Price/Issue 1 3 6 2” x 3” $ 75 $ 68 $ 58 4.5” x 1.5” $ 80 $ 74 $ 67 4.5” x 4.75” $200 $184 $163 8.5” x 5.5” $400 $360 $310 full page $655 $590 $510 Discounts will be available for issues not shown Please send your jpg to: Renate Valois at [email protected]. Make checks payable to: American Chemical Society and mail to: Bill Szabo, Treasurer 3950 Mahaila Avenue, B-36 San Diego, CA 92122 SECTION E-MAIL LISTSERVER! Get up-to-the-minute reminders of local events and develop dialogs with your fellow members! To subscribe to our moderated listserver: 1. Send an e-mail with SUBSCRIBE TO LISTSERVER in the subject line, and your name and e-mail in the body of the message to Ken Poggenburg at [email protected]. 2. If you receive a message from the postman, reply to confirm that you wish to be added to the list, otherwise it will not take effect. 3. You will receive reminders approx. 5-7 days prior to upcoming events and messages of general interest to members. 4. To post topics for discussion, or informational items to the listserver members, send the message to [email protected]. 5. If the moderator approves the post, it will be sent to the members. NOTE: That is the letter "l", not the number "one" following the word "chemist". Executive Committee Meeting Dates 2016 Thursday Tuesday

6:00 – 8:00 pm October November

Meetings will be held at: 9381 Judicial Drive, Suite 160 San Diego, CA 92121

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The San Diego Section of the American Chemical Society would like to thank our Corporate Sponsors. Here are a few examples of our annual outreach programs that are made possible by their generous donations: Mad Science - Stage demonstrations for 4th and 5th graders which make science fun for kids! Last year the program was viewed by over 8000 students in low-income areas and from military families. ChemExpo - A science event for middle and high school students held annually for the past 28 years. It features live stage demonstrations and interactive booths that teach kids about applied science. Last year over 1000 local students participated! EarthFair – We participate in the world’s largest free annual environmental fair, held in Balboa Park.

CONSIDER SPONSORSHIP OF THE ACS SAN DIEGO SECTION The San Diego Section of the ACS is looking for organizations that are committed to advancing science and education in the greater San Diego area by providing financial support. There are several ways to get involved, and each one comes with its own benefits and privileges. For further information please contact Jonathan Lockner, Interim Chair, Fundraising Committee, at [email protected]

ORGANIZERS NEEDED! The San Diego Section of the American Chemical Society is looking for volunteers to organize an ACS Western Regional Meeting. Exact dates are flexible and yet to be determined, but it will be held between 2018 and 2020. We are currently looking to fill the positions of General Meeting Chair and Program Chair(s). If you are organized, work well with others, and want to expand your professional network to a national scale, you may be a great fit for either of these positions. The General Meeting Chair will be responsible for overseeing the planning of the meeting venue and logistics while the Program Chair(s) will fill events and speaker lists. Location, duration and desired attendance are based on the vision of the organizers. If you have an idea for a large meeting held here in San Diego, this is your way to make it happen. For more information please contact:

Graeme Freestone, 2016 Chair San Diego Section of the American Chemical Society [email protected]

SHARE SCIENCE AS A CHEMISTRY AMBASSADOR You can help kids learn to understand and love science as a Chemistry Ambassador, and ACS is ready to help you do it. Volunteer with youth groups, summer camps, and scouts in your community. The Chemistry Ambassadors program has tips and resources to support your outreach to your neighbors or students in your area. The Chemistry Ambassadors program makes it easy to stay involved, whether you have a lot of time or just a little. See www.acs.org/chemistryambassadors for more details.

VOLUNTEER WITH KIDS & CHEMISTRY Kids & Chemistry is a community-based program that brings together scientists and children to do hands-on science activities. Volunteers include ACS members, ACS Student Chapters, and corporate groups. Volunteer efforts can be implemented as a full program administered by an ACS local section or by an individual as a one-time classroom visit. For more information please see: http://www.acs.org/content/acs/en/education/outreach/kidschemistry.html

ANNUAL SAN DIEGO ACS LOCAL SECTION ELECTIONS 2017 ARE ALMOST HERE! Nominations for Section offices are now in order. Per our Bylaws, the current Chair-Elect will assume the Chair, but other positions are open for election, including Chair-Elect • Secretary • Treasurer 2 Councilors • 3 Alternate Councilors • 3 Members-at-Large Councilors, Alternate Councilors, and Members-at-Large serve for three years, and all incumbents may succeed themselves. We encourage the active participation of our members! If you have an interest in becoming involved in the ACS-San Diego Section and want to make a self-nomination as a candidate for an elected position, please contact: Jim Shih at [email protected] Send your bios to Jim Shih at [email protected] and Renate Valois at [email protected]

NOTE: VOTING WILL AGAIN BE DONE ELECTRONICALLY Voting will be done electronically using your email address on record for the ACS. If you wish to receive a paper ballot instead, please call or e-mail Jackie Trischman, Election Coordinator, at 858-414-3323, or [email protected] by Nov. 1 and leave your name and mailing address. You will be mailed a paper ballot. If you do not request a paper ballot, you will receive instructions on how to vote via email. Please be sure your email address on file with the ACS is current! To update your email address with the ACS, use www.chemistry.org

CELEBRATE! MOLE DAY, OCTOBER 23RD Don't forget to celebrate Mole Day on October 23 from 6:02 a.m. to 6:02 p.m. For more information visit http://www.moleday.org/

EXECUTIVE BOARD CANDIDATES FOR 2017 ACS SAN DIEGO SECTION CANDIDATE BACKGROUNDS -----------------------------------------------------------------------------------------------------------------------------------CHAIR-ELECT JENNIFER BARBER-SINGH Jennifer received her undergraduate degree in Chemistry from Clarkson University in 1997, continued at Clarkson earning a Master’s degree in 1999, and investigating the role of block copolymers for use in personal care products with Professor Stig Friberg. She then moved to the University of Illinois at Chicago where she was awarded a PhD in Analytical Chemistry for her work in developing methods for the analysis of neurochemical signaling using push-pull perfusion in freely behaving animals. This work led her to a postdoctoral position at The Scripps Research Institute with Professor Takao Yagi where she evaluated a gene therapy for mitochondrial disorders using a rodent model of Parkinson’s disease, and later returned to the Yagi lab to investigate a rodent model of Leber’s Hereditary Optic Neuropathy, a sudden onset of blindness linked to mitochondrial dysfunction. She is currently investigating a novel treatment for malaria in Professor Laurent Mosnier’s lab at Scripps, using a transgenic human-model of malaria in mice. In addition to her accomplishments in science, she also volunteers extensively at a private school in La Jolla where she is in charge of multiple committees over the course of the school year. She has recently become more active in the Local ACS Section where she applied for and was awarded a grant to host a Science Café symposium intended to reach beyond the local science community. SECRETARY WILLIAM TOLLEY Bill earned a B.S. and M.S. in Metallurgical Engineering from the University of Utah and a Ph.D. in Inorganic Chemistry from the Brigham Young University. His research focused on the interactions of inorganic compounds with supercritical fluids. This work led to a patent describing novel processing to purify metals using vapor-phase chemistry. He worked for seven years as Production Manager, and then promoted to Director of Quality Assurance at Quantum Group Inc. in San Diego. In 2008, he joined Seacoast Science, Inc., located in Carlsbad, CA. He led development of the Mini-GC, which was successfully launched in August 2009. His responsibilities include sensor design and testing, and proposal development. In 2007, he chaired the subgroup to write new alarm certification protocols under UL 2035 - Single Station Gas Detectors. He is a member of the American Chemical Society, where he is a member of the San Diego Section executive committee and in his twelfth year as Secretary to the Section. He is a lifetime member of Sigma Xi (The Scientific Research Society). He has authored or co-authored 26 U.S. patents and over 75 journal articles and presentations in chemical sensing, process control and materials production. TREASURER GRAEME FREESTONE Graeme received his undergraduate degree in chemistry from The University of Manchester (2001), followed by a DPhil from The University of Oxford (2005) in the labs of Professor Timothy Donohoe. He then moved to San Diego to undertake a three-year postdoctoral position at The Scripps Research Institute with Professor KC Nicolaou, where his work focused on the total synthesis of complex natural products. Since leaving academia Graeme has worked as a medicinal chemist in the areas metabolic diseases and cognitive disorders at Metabasis Therapeutics, Helicon Therapeutics and Dart NeuroScience (his present position). Graeme co-organizes and instructs an introduction to medicinal chemistry course aimed at local graduate students and post-docs to help ease their transition from academia to industry. Since its inception in 2011, Academics to Industry has been presented multiple times at UCSD, UCLA, TSRI and UCSB. He is active in the ACS San Diego Local Section serving as Member-at-Large (2011-2014), Chair of the Younger Chemists Committee in (2014), Chair-elect (2015) and Chair of the San Diego Section (2016). COUNCILOR HUI CAI Hui was the 2009 Chair of the ACS San Diego Section, and has served on the executive committee of the ACS San Diego Section for over 10 years. She is Vice President of Corporate Alliances and Head of PR and Corporate Communications at WuXi AppTec a global R&D enabling platform company. Prior to that, Hui spent ten years at Johnson & Johnson Pharmaceutical Research and Development, co-leading multiple small molecule drug discovery programs. She is a co-author and co-inventor to over 40 scientific publications and issued or pending patents. Hui served as a Commissioner at the City of San Diego Science and Technology Commission as appointed by the Mayor of San Diego. She was also Chairwoman of Board at Sino-American Biomedical and Pharmaceutical Professionals Association. She received her PhD from The Scripps Research Institute, and an MBA from the UCSD Rady School of Management as a DLA Piper - Athena FlexMBA Scholar.

COUNCILOR KEN POGGENBURG Ken has been a member of the ACS since 1959. He joined the San Diego Section in 1984 when he came to Hybritech as Director of Therapeutics to develop radiolabeled monoclonal antibodies for diagnosis and therapy. He served as Chair in 1991, when the San Diego Section celebrated its fiftieth anniversary, and again in 2002, after returning from a five year stay in Ohio. While in Ohio, Ken was active in the Columbus Section as Public Relations Chair and on the Government Affairs Committee. He was elected Alternate Councilor in 2004, and a Councilor in 2008. He is currently a member of the ACS Committee for Public Relations and Communications. Locally, Ken is Chair of the Senior Chemists Committee and Moderator of the Section listserver. He was also a member of the 2007 Western Regional Meeting Organizing Committee. After his first tour as Chair, he served as Councilor as a member of the Committee on Economic and Professional Affairs until he took a new job in Ohio in 1994, from which he retired in 1999 and returned to San Diego. Ken has a PhD in nuclear chemistry from UC Berkeley, and spent 13 years at Oak Ridge National Laboratory before moving into commercial radiopharmaceutical development. He was recently named an ACS Fellow.

ALTERNATE COUNCILOR SURYA K. DE Surya obtained his Ph.D. in Organic Chemistry from Jadavpur University, Kolkata (Calcutta), India. He worked at the University of Washington, (Seattle), Purdue University, (West Lafayette, Indiana), The Scripps Research Institute, and Sanford-Burnham-Prebys Medical Discovery Institute in several drug discovery programs. His research work was highlighted in Nature Review, Drug Discovery and Chemical & Engineering News. He is an Editorial Board Member of The Open Organic Chemistry Journal, The Open Catalysis Journal, Current Catalysis, and Current Chemical Research. He is an author of more than 80 peer-reviewed international journals and the inventor of several patents. He is an elected fellow of the Royal Society of Chemistry, London, UK (FRSC, 2010). He is a member of Indian Science Congress. He is actively involved in the ACS – San Diego Section since 2007 and has been an ACS member since 2001.

ALTERNATE COUNCILOR BEN PRATT Ben is Associate Director of Chemistry at Akarna Therapeutics in Encinitas, California. He received his B.A. in chemistry with high honors from Dartmouth College in 2000. He spent 3 years as a process chemist at Rhodia ChiRex in Boston, synthesizing chiral building blocks and optimizing the route to Vertex’s clinical candidate VX-950 (Telaprevir). In 2008, Ben earned his Ph.D. from The Scripps Research Institute where his thesis work focused on the total synthesis of natural products and their analogues in the lab of Professor K.C. Nicolaou. Since leaving TSRI, Ben was a medicinal chemist at several San Diego based biotech companies focused in the areas of oncology, metabolic disease and cognitive function. A 15-year member of the ACS, Ben became involved in the San Diego Local Section in 2010 and has served as co-chair of the Younger Chemists Committee, assistant treasurer, 2015 chair and was appointed as alternate councilor in 2016. With his colleagues in the YCC and the help of an ACS innovative projects grant, Ben co-founded the Academics 2 Industry lecture series in 2011 that serves as a primer course for aspiring medicinal chemists. Over the past few years, A2I has been presented multiple times at TSRI, UCLA, UCSB, and UCSD and won the 2015 ACS ChemLuminary "Creative Local Section Younger Chemists Committee Event". ALTERNATE COUNCILOR JOHN SCHINDLER John received a BS in Engineering Science (1970) and a M.S.C. (1972), in chemistry, at the Cleveland State U. Concurrently, he worked at CA Litzler, at Republic Steel’s Research Center and with Hydrotechnic Corporation and attended the Winter Institute (1970) of the Quantum Theory Project at the U. of Florida. At CSU, he was a Standard Oil Summer Research Fellow and a Lecturer in Engineering Technology in 1972. In 1973 he joined the Coatings Research Center of PPG (Pittsburgh) and was an evening post-graduate student at both Carnegie-Mellon U. and the U. of Pittsburgh. He entered USC in 1976 and received his Ph.D. (1980) and spent two years as NSF Post-Doctoral Fellow at UCLA. He joined the USD chemistry department in 1982 [DOE-ASEE Summer Faculty Fellow (1983) in the Solar-Thermal Chemicals & Fuels program at JPL]. He left USD in 1986 for an ONT-ASEE Research Fellowship in the Materials Research Branch of the Naval Ocean Systems Center (SpaWar). He joined Reagents Applications (1991-2) as Senior Chemist in Research and the San Diego Air Pollution Control District as Associate Chemist in the Monitoring & Technical Service Department (1992), supervising outside contractors in the pollution testing of newly constructed potential sources until transferring (2006) to the ambient air monitoring section, performing gas chromatographic organic vapor analysis on ambient air samples. John took early retirement in August 2009. He has authored/co-authored over 15 research papers. He is a member of the ACS, American Institute of Chemical Engineers, Society for Applied Spectroscopy, Sigma Xi, Spectroscopy Society of Pittsburgh, and is a Registered Professional Engineer in Ohio and Pennsylvania. John has been Chair-Elect, Chair and Past Chair of the ACS San Diego Section (1983-85), Member-at-Large of the ACS Executive Committee (1986-89, 1997-99, 2012), & Alternate Councillor (2013-present).

MEMBER-AT-LARGE JAMES CALDWELL James graduated summa cum laude from Northern Illinois University with a bachelor’s in biology, earned his master’s degree in chemistry from San Diego State University, and his Ph.D. degree in chemistry from the University of California San Diego in the joint doctoral program with San Diego State University. He is currently in a three year postdoctoral fellowship specializing in X-ray crystallography at San Diego State University research foundation with Distinguished Professor Sanford Bernstein. James is a 5-year member of the ACS. MEMBER-AT-LARGE BILL SZABO Bill received his undergraduate degree in chemistry from Lehigh University, worked for two years as an R&D chemist at Johnson & Johnson’s McNeil Laboratories near Philadelphia, and earned his Ph.D. degree in heterocyclic and medicinal chemistry from the University of Florida. He held a two-year postdoctoral fellowship in natural product synthesis at Wesleyan University with Professor Max Tishler, former President of Merck Research Laboratories and a past ACS President. Next, Bill was recruited by Alfred Bader, co-founder of the Aldrich Chemical Company, and worked for 18 years at Aldrich in Milwaukee in various management positions in R&D, production and advertising. He then relocated to the Sigma-Aldrich corporate headquarters in St. Louis and spent four years in the sales and marketing of bulk pharmaceutical intermediates, positions which included Sales Director for North America and Vice President of International Sales. In 1998 he took an early retirement, moved to San Diego, and consulted for the next 14 years in drug and business development. In 2012 he co-authored a chapter in a book on transition metal-catalyzed asymmetric cross-coupling reactions. He is a 39-year member of the AAAS and a lifetime member of the Japan Society of San Diego & Tijuana. Bill is a 48-year member of the ACS. He served on the Organizing Committee of the 2007 ACS Western Regional Meeting, was Chair of the San Diego Section’s Public Relations and Fundraising Committees, and organized the Section’s 2009 and 2010 San Diego Science Festival exhibits. Bill was Chair of the ACS-San Diego Section in 2011, for which year the Section received the ChemLuminary Award for Outstanding Performance by a Local Section (Large Size Category). He received the Section’s Outstanding Committee Chair Award in 2014 and the Tony Bottone Award for Outstanding Service in 2015. Bill served as the Section’s Treasurer for five years (2012-2016). MEMBER-AT-LARGE JOANN UM Joann’s passion for chemistry began as an undergraduate at Columbia University, where she synthesized retinal analogs for elucidation of the visual transduction pathway. Her synthesis career continued at Merck & Co., Inc. (Rahway, NJ), University of California, Berkeley, (M.S.), and Genentech, Inc. (South San Francisco, CA). Joann then earned her Ph.D. under the direction of K.N. Houk (University of California, Los Angeles), where she used quantum mechanical methods to investigate pericyclic reactions, asymmetric reactions, and organocatalysis. Joann has taught chemistry at numerous colleges in the San Francisco, Los Angeles, and San Diego areas and is currently Assistant Professor of Chemistry at Southwestern College (Chula Vista, CA). She has been an active member of the American Chemical Society and 2YC3 (Two-Year College Chemistry Consortium) since 2011 and has been advising the Student Chapter of the American Chemical Society at Southwestern College since 2012.

Vote by November 21st

CHEMLUMINARY AWARD

The San Diego Section received the ChemLuminary Award for the Outstanding or Creative Local Section Younger Chemists Committee Event at the 252nd ACS Fall National Meeting & Exposition in Philadelphia, Pennsylvania, August 2016. The award was in recognition of the Academics to Industry seminar series.







Councilor Desiree Grubisha accepts the award on behalf of the Section From left to right: National YCC Chair Natalie LaFranzo, Desiree Grubisha, ACS President Donna Nelson Photo credit: John Palmer

The Academics to Industry Team: Ryan Clark, Graeme Freestone, Ben Pratt, Chris Smith, Mark Tichenor Academics to Industry was designed, with the backing of an ACS IPG grant, to provide an introduction to students who are considering a career in medicinal chemistry. Scientific education often includes little instruction for the specific types of careers that students will pursue after they earn their degrees. This seminar series was intended to help students better understand the career opportunities available in drug discovery and provide a framework for learning the chemistry and biology concepts that they will need to excel in these careers. Text: Graeme Freestone

THE SOUTHERN CALIFORNIA PHARMACEUTICAL DISCUSSION GROUP (SCPDG) OF AAPS HELD A JOINT MEETING WITH THE ACS - SAN DIEGO SECTION Kenneth G. Waterman, Ph.D. President and Founder, FreeThink Technologies Using modeling from highly accelerated stability testing (ASAP) to determine product shelf life On September 8th, 2016, Dr. Kenneth G. Waterman from Free Think Technologies, spoke about the chemical stability of several drugs. The meeting was organized by The Southern California Pharmaceutical Discussion Group (SCPDG) in collaboration with the American Chemical Society, San Diego Section, and it took place at Knobbe Martens Law office’s seminar room. Attendees enjoyed Dr. Waterman's seminar. He discussed the methods of rapidly and accurately assessing the chemical stability of pharmaceutical dosage forms with respect to the major degradation mechanisms generally observed in pharmaceutical development. His seminar also covered general thermal methods, as well as accelerated aging methods appropriate to oxidation, hydrolysis, reaction with reactive excipient impurities, photolysis and protein denaturation, on small and large-molecule active pharmaceutical ingredients.

Kenneth Waterman

Kenneth Waterman, Adam Grobin Text: Surya De Photo credit: Bobette Frye

SECOND ANNUAL ACS WEST COAST ANALYTICAL CHEMISTRY SYMPOSIUM The second ACS West Coast Analytical Chemistry Symposium was held on September 20th at Dart NeuroScience LLC. The event was conceived as a forum to facilitate a discussion of current topics in analytical chemistry. The full day event featured 8 lectures, and an equal number of posters were presented by a diverse array of analytical scientists. More than 100 attendees filled the lecture hall and foyer at the Dart NeuroSciences. The event was made possible from the generous support through an ACS Innovative Projects Grant written by Julann Miller and 9 company sponsors. The organizers, Christina Aurigemma, William Farrell, Chris DeVore, Graeme Freestone, Julann Miller, and Gerard Rosse, look forward to next year’s event to further tap into the valuable analytical chemistry knowledge present here in Southern California. Volunteer and presentation opportunities are available for next year’s event. Please contact one of the organizers to get involved.

Symposium Speakers, poster presenters





l to r: Julann Miller, Curtis Moore, Christina Aurigemma

One of the very popular raffles

Photos and text provided by Analytical Symposium Organizing Committee



Focusing on the chemistry of fibers and forensics!

Theme: Forensics- Solving Mysteries with Chemistry

ChemExpo2016 Celebrating Our 29th Year!

Saturday, October 22, 2016 11 AM - 3 PM Students: Come early! In collaboration with San Diego Extra credit handouts end at 2:00 pm Open to anyone interested in Chemistry. All ages welcomed!

Miramar College Chemistry Faculty, the San Diego Section of the American Chemical Society (ACS) will celebrate National Chemistry Week (NCW) by hosting the CHEM EXPO at San Diego Miramar College, 10440 Black Mountain Rd,

It’s Free! It’s Fun! It’s Educational!

The CHEM EXPO instills greater public awareness of the importance of chemistry in our everyday lives and the roles that chemists play in our community.

WHAT TO EXPECT: • Exhibits by Local Companies & Organizations • Chemistry Demonstrations • Hands-On Activities • Free Raffles • Middle & High School Extra Credit (at teacher discretion) • and Much More!

To v olun teer and Pa for ul B free Local Companies & Organizations: ruin spac Sign Up to Showcase Your Exhibits! sma e for at p educ aulb ation @san al ex d i e go h acs.o ibits conta ct: rg

No Charge!

Sponsored by the San Diego Section of the American Chemical Society • www.sandiegoacs.org.

Sino-American Biotechnology & Pharmaceutical Professional Association

12th Annual SABPA Pacific Forum Forum 3rd Pacific Bio-Partnering



When: 8:00 am - 5:00 pm, Saturday, October 1, 2016 Where: Hilton Del Mar, 15575 Jimmy Durante Blvd, Del Mar, CA 92014 RegistraPon: hQps://whova.com/portal/registraPon/aspff_201610/ Excitement is in the air! This year’s SABPA Pacific Forum will be packed with many top-notch speakers. What a unique opportunity to have the disEnguished vice chancellor for Health Sciences and dean of the School of Medicine at UCSD along with mulEple deans of the Schools of PharmaceuEcal Sciences from many of the top Chinese universiEes under one roof to share their insights and visions! You will also hear about recent industry success stories, novel scienEfic approaches and new models of collaboraEons from many widely-respected leaders of biomedical and pharmaceuEcal industry across the Pacific Rim. In addiEon, a panel discussion on immuno-oncology model system will be included. This forum is the place to meet with industry leaders and to network with your peers. It is the event that you can’t afford to miss!

Confirmed speakers and panelist David Brenner, MD Vice Chancellor UCSD Health Sciences Dean UCSD School of Medicine

Henry Ji, PhD CEO and President Sorrento TherapeuEcs

Demin Zhou, PhD Dean School of PharmaceuEcal Sciences, Peking University

Ming-Wei Wang ,PhD Dean School of Pharmacy Fudan University

Mao Mao, MD PhD CSO BGI genomics

Yun He, PhD Dean School of Pharmacy, Chongqing University

Jin Li, PhD CEO and Chairman HitGen

Xiao-Kun Zhang, PhD Dean School of PharmaceuEcal Sciences, Xiamen University

Panel Discussion Immnuno-oncology model systems to develop safer and more precise cancer treaments Karsten Sauer, Ph.D. Director Cancer Immunology, Oncology R&D, Pfizer

3rd Pacific Bio-Partnering 2016

Michael Seiler, Ph.D. PorZolio Director, Commercial GeneEcally Engineered Models Taconic Biosciences, Inc.

Schoenberger,PhD Professor La Jolla InsEtute for Allergy and InflammaEon

One-on-one meeEng with biotechnology, pharmaceuEcal, and investment companies from San Diego and Asia to explore potenEal partnerships and collaboraEons.

OBITUARIES

Nobel Laureate Roger Tsien UC San Diego professor helped develop glowing proteins, illuminating life

Nobel Laureate Roger Tsien, PhD, UC San Diego School of Medicine professor and Howard Hughes Medical Institute investigator, died August 24, 2016. Roger Tsien, PhD, co-winner of the 2008 Nobel Prize in chemistry and Professor of Pharmacology, Chemistry and Biochemistry at University of California San Diego School of Medicine for 27 years, died August 24th in Eugene, Oregon. He was 64. Tsien’s work literally illuminated science. With Osamu Shimomura, PhD, an emeritus professor at the Marine Biological Laboratory in Woods Hole, Massachusetts, and Martin Chalfie, PhD, a professor of biological sciences at Columbia University, Tsien helped scientists peer within living cells and organisms as never before, earning not just the 2008 Nobel Prize but scores of subsequent awards and accolades. Biography in brief Roger Yonchien Tsien was born February 1, 1952 in New York City, the third son of immigrant parents. He was a scientist from early childhood, sketching out chemistry experiments as an 8-year-old in a notebook now kept in the Nobel Museum in Stockholm, Sweden. His first Boy Scout merit badge was in chemistry. In 1968 at the age of 16, he took first prize in the prestigious Westinghouse Science Talent Search for high school seniors. He attended Harvard College, graduating summa cum laude in chemistry and physics in 1972, then earned his doctorate in physiology in 1977 at the University of Cambridge in England. Before coming to UC San Diego in 1989, he worked as a research assistant in Cambridge and then as a junior professor at UC Berkeley. Tsien was a member of the Institute of Medicine, the American Academy of Arts and Sciences, the U.S. National Academy of Sciences and the Royal Society of London. Among his awards: the Gairdner Foundation International Award, the American Chemical Society Award for Creative Invention, the Heineken Prize for Biochemistry and Biophysics, the Max Delbruck Medal in Molecular Medicine, the Wolf Prize, and the Keio Medical Science Prize. He was a good friend of the ACS - San Diego Section, often attending the annual San Diego ACS/UCSD MedChem Symposium. In 2005 he received the ACS - San Diego Section’s Distinguished Scientist Award. Text: Scott LaFee, UC San Diego News Center Tom Beattie

Celia Marshak

Celia passed away last October 3, 2015. Celia received her Bachelor’s degree from Hunter College, and her MA and PhD in biochemistry from Columbia University. She was an active member of the San Diego ACS Section for many years, having served as Section Chair and receiving the Section's 1994 Outstanding Service Award. Celia was a professor emerita in the Chemistry Department at SDSU, where she also served as Assistant Dean for Student Affairs in the College of Sciences, 1972-93. A celebration of her life is planned for Sunday, October 2nd, at 1:00 pm at the Scripps Cottage on the campus of SDSU. Text: Tom Beattie Barbara Sawrey

SUMMARY OF THE SAN DIEGO SECTION EXECUTIVE COMMITTEE MEETING MINUTES September 6, 2016 Treasurer's Report – Since last meeting: Received $3,800 in sponsorships, primarily for MedChem and Analytical Symposia, completing expenses for councilor travel; $16,700 surplus (last year at this time we had $17,200 surplus); receivables $500 for Analytical Symposium (money received but not posted); need to resolve reimbursement for Jonathn Lockners trip to Leadership Institute (National giving conflicting answers regarding whether a check has been sent); current financial assets - $355K (Vanguard fund increasing); Graeme Freestone has agreed to run for treasurer for 2017 Chemistry and the Law Event / August Monthly Seminar - 60 attendees (several attendees were appreciative of North County location); sponsored by ALT September Monthly Seminar – West Coast Analytical Symposium, Sept. 20, Dart NeuroScience, eight speakers, attendance limited to 120 Southern California Pharmaceutical Discussion Group / SD ACS Seminar – Sept 8, venue: Knobbe Martens rotunda Awards Banquet – Oct 13, Prof. Ed Dennis (UCSD) as honoree, topic "Fats and Lipids Enzymes in Health and Disease"; discussion to adjust stipends associated with Section awards: Tony Bottone Award - $250, Chair and Educator Awards at $150 Science Café – Tentatively at Fleet Science Center Nov 2-3, Rob Knight (UCSD) as headline speaker, topic: the microbiome Review of National Meeting – Council approved four new international chapters - Beijing, Southern China, Iraq, India; 12,800 attendees, National’s budget in the black ChemLuminary Awards – Section nominated for four, won one – Outstanding Performance, Local Section Younger Chemists Committee Event Western Region Board Meeting - Eight of 14 Sections represented, Hawaii to join Western Region; Desiree Grubisha has agreed to serve as secretary for the Western Region Board Memorials for Notable Section Members - Roger Tsien (Nobel Laureate) passed away recently; UCSD expected to hold a memorial; Celia Marshak (formerly SDSU Professor of Biochemistry and Assistant Dean) – Oct 2, Memorial at SDSU Scripps Cottage Government Affairs – Jonathan Lockner as 2017 Chair wants to stress advocacy, particularly emphasizing science in local community; envisions an event involving elected officials followed by discussion of how Section members can be effective advocates Website – Need Webmaster who will keep the site up-to-date; users need reason to access the site, so it needs frequent, possibly daily, updating 2017 Plans – Reviewed possible topics for meetings Education Outreach – Sent letters to local secondary schools inviting a competition for outreach to K-12 students; will start a newsletter with simple, non-hazardous experiments for youngsters National Award Nominations – A letter to be sent to local firms and institutions soliciting nominees for the national awards to increase the opportunities for awards to local members Grants – PolyGrid Symposium funds not awarded, summary of decision is coming; Project MEET – designed to get senior chemists interacting with students to capture science using electronic media; Virtual Event Participation Grant – intended to encourage member participation from remote locations – proposing purchasing equipment to disseminate ExComm Meeting or other Section events using Webcast / Webinar format Next meeting: Oct. 6

ACS-Hach Programs ACS-Hach Professional Development Grant Funds professional development experiences for secondary chemistry teachers. Award Amount: Up to $1,500 Application Period: October 15th - December 15th annually ACS-Hach Land Grant Teacher Scholarship Provides financial support to obtain a chemistry undergraduate degree and chemistry teaching credentials at one of our 72 partner institutions. Award Amount: $10,000 for full-time study Application Period: Contact participating universities directly for application details ACS-Hach Post-Baccalaureate Teacher Scholarship Provides financial support for chemistry graduates with limited work experience to obtain a masters degree in education or teacher certification in chemistry. Award Amount: Up to $6,000 for full-time study and up to $3,000 for part-time study Application Period: February 1st – April 1st ACS-Hach Second Career Teacher Scholarship Provides financial support for chemistry professionals to obtain a masters degree in education or teacher certification in chemistry. Award Amount: Up to $6,000 for full-time study and up to $3,000 for part-time study. Application Period: February 1st – April 1st About ACS-Hach Programs The ACS-Hach Programs provide financial support for future and current high school chemistry teachers. Learn more. Contact us: E-mail: [email protected] -- Phone: (800) 227-5558 ext. 8178

CHEMISTRY FOR YOU AND YOUR KIDS The Fate of Calcium Carbonate Calcium carbonate is in eggshells, seashells, and chalk. In the activity below, you can make a chemical reaction that causes calcium and carbonate to come apart and produce the gas carbon dioxide! You can also see what an egg or bone is like when its calcium is removed! You will need eye protection sheet of paper pencil eggshell calcium tablet (oyster shell) white chalk metal tablespoon 2 small paper or plastic cups

water vinegar 2 straws or droppers egg chicken bone 2 jars with lids aluminum foil

1. Cover your work surface with newspaper or paper towels. Place your eggshell, 1/4 piece of chalk, and calcium tablet on your work surface. 2. Use the back of a tablespoon to crush each of your samples into small pieces. Make a chart like the one shown. Place half of each sample in the row marked water and half of each sample in the row marked vinegar. 3. Place a few drops of water on the samples in the water area and observe them very closely. What did you see? Now place a few drops of vinegar on the samples in the vinegar area. What did you observe?

Eggshell

Calcium Tablet

Chalk

Water

Vinegar

If this chemical reaction causes the calcium and the carbonate to come apart, what do you think would happen to an egg if it were left in vinegar for a few days? How about a bone, which has a lot of calcium phosphate. Let's try it and find out! Place an egg and a chicken bone in separate jars. Add enough vinegar to cover them completely. Cover the opening of each jar with aluminum foil. Observe the egg and bone over the next three days. What do you notice? At the end of three days, take each one out of its jar. How are they different from when you put them in? What do you think caused them to look and feel the way they do? Excerpt: "The Best of WonderScience," pg. 157, Delmar Publishers, 1997

***************************************************************************** LOOKING FOR A CHEMIST? CHEMPLOYMENT IS THE ANSWER! THE SAN DIEGO CHEMIST is read by nearly 3000 chemists and biochemists in San Diego and Imperial Counties. A two-month ad costs only $80.00! For information contact: Renate Valois - [email protected]

Attention Companies! Do you hire student workers? If you have open positions in chemistry and biochemistry that would be of interest to college students, such as summer internship opportunities, here is a list of contacts you’ll want to keep handy. The people listed below are the faculty advisors of the ACS Student Affiliate groups for all chemistry programs in San Diego County. These professors can get the word out to all chemistry and biochemistry majors at their schools about jobs, career fairs, open houses, etc.

California State University, San Marcos Jacqueline Trischman [email protected] 760-750-4206 Palomar College Greg Elliot [email protected]

858-531-1149

Point Loma Nazarene University Sara Choung [email protected] 619-849-2627 San Diego Mesa College Dwayne Gergens [email protected]

619-388-2609

San Diego Miramar College Fred Garces [email protected] 619-388-7493 San Diego State University (SDSU) Mikael Bergdahl [email protected] 619-594-5865 Southwestern College, Chula Vista David Hecht [email protected] 619-421-6700x5461 University of California, San Diego Joe Cribari [email protected] 858-822-4055 Gourisankar Ghosh [email protected] 858-822-0469 Judy Kim [email protected] 858-534-8080 NERM SERMACS MWRM SWRM

2016 ACS REGIONAL MEETINGS October 5- 8 October 23 - 26 October 26 - 28 November 10 – 13

Binghamton, NY Columbia, SC Manhattan, KS Galveston, TX

ACS PUBLICATIONS LAUNCHES MOBILEOPTIMIZED WEB PLATFORM ACS Publications has introduced ACS2Go, pubs.acs.org/acs2go, a new, mobileoptimized website that enriches the reading and browsing experience for readers of ACS content. ACS2Go can be accessed at pubs.acs.org on a tablet or smartphone. Please see for more information: pubs.acs.org/acs2go. ACS INDUSTRY VOICES ACS Industry Member Programs brings you the ACS Industry Voices blog, with weekly posts that share stories, lessons, advice, and general musings from around the chemical technology field.

University of San Diego Tammy Dwyer [email protected]

619-260-4030

ACS Webinars™ For upcoming Webinars in October/November see: http://www.acs.org/content/acs/en/acswebinars.html For the ongoing 2016 Drug Design and Delivery Symposium series, see: http://www.acs.org/content/acs/en/acswebinars/collections/2016-drug-design.html YOUR AD HERE! Place your ad in the next issue of The San Diego Chemist For information contact: Renate Valois - [email protected]

UPCOMING EVENTS SENIORS/RETIREES/CONSULTANTS/ETC. BREAKFAST Denny's 4280 Clairemont Mesa Boulevard, San Diego, CA Tuesday, October 4, 2016, at 9:30 AM ********** DR. EDWARD A. DENNIS 2016 Distinguished Scientist Award Banquet UCSD Faculty Club – UCSD 9500 Gilman Drive, La Jolla, CA Thursday, October 13, 2016 ********** CHEM EXPO Solving Mysteries Through Chemistry San Diego Miramar College, 10440 Black Mountain Road, San Diego 10440 Black Mountain Rd, San Diego Saturday, October 22, 2016 ********** HOLIDAY PARTY Sufi Mediterranean Cuisine 5915 Balboa Avenue San Diego, CA 92111 Thursday, December 1, 2016

THE SAN DIEGO SECTION OF THE AMERICAN CHEMICAL SOCIETY WELCOMES ITS NEW MEMBERS

Michael Bird Mike Cohen Holly Deniston-Sheets Whitney Francis Sierra Gandolfo Kelly Goodwin Patricia Jennings Joseph Kakkassery Joseph Kim Bryant Lim Chung-Yon Lin Changqi Liu Chuze Ma Kathleen Moorman Andreas Naundorf Alina Schimpf Anita Targosz Erin Wood

2016 EXECUTIVE COMMITTEE & COMMITTEE MEMBERS SAN DIEGO SECTION OF THE AMERICAN CHEMICAL SOCIETY

EXECUTIVE COMMITTEE Chair Graeme Freestone, Dart NeuroScience LLC, [email protected] Chair-Elect Jonathan Lockner, Calibr, [email protected] Past-Chair Ben Pratt, Akarna Therapeutics, [email protected] Secretary William Tolley, Seacoast Science, Inc., [email protected] Treasurer Bill Szabo, [email protected] Councilors Thomas R. Beattie (2018) Hui Cai, WuXi AppTec (2016) Desiree Grubisha, Halozyme Therapeutics (2018) John Palmer, UCSD (2017) Ken Poggenburg (2016) David Wallace, Wallace Scientific Consulting (2018) Alternate Councilors Paul Bruinsma, HP Inc. (2017) Surya K. De, Sanford-Burnham Medical Research Institute (2016) Julann Miller, Waters Corporation (2017) Ben Pratt, Akarna Therapeutics (2016) John Schindler (2016) Jim Shih, Eli Lilly & Co (2017) Members-at-Large James Caldwell (2016) Ryan Clark, Inception Sciences, Inc. (2017) Mark Rosen, Aetheria Therapeutics (2017) Joann Um, Southwestern College (2016) Mark Wentland (2016) STANDING & SPECIAL COMMITTEES Award Nomination Committee Thomas R. Beattie (Chair) ChemExpo Paul Bruinsma (Chair), HP Inc. Julann Miller, Waters Corporation Communications Committee Paul Bruinsma, (Chair), HP Inc. Surya K. De, Sanford-Burnham Medical Research Institute Desiree Grubisha, CSUSM Ken Poggenburg David Wallace, Wallace Scientific Consulting Renate Valois (Newsletter Editor) Education Committee Haim Weizman (Chair), UCSD Joann Um (Co-Chair), Southwestern College EarthFair Julann Miller, Waters Corporation Finance Committee Bill Szabo (Chair) Tom Beattie John Schindler Fundraising Committee Jonathan Lockner (Interim Chair) Government Affairs Committee Hui Cai, WuXi AppTec (Chair) Ken Poggenburg Law Committee Ryan C. Smith, Duane Morris LLP Mad Science Program Thomas R. Beattie MedChem Symposium Ben Pratt (Co-Chair), Akarna Therapeutics Mark Tichenor (Co-Chair), Janssen Pharmaceuticals, Inc. David Wallace (Co-Chair), Wallace Scientific Consulting Membership Committee OPEN Nominations Committee Jim Shih, Eli Lilly & Co. Picnic Committee Jim Shih, Eli Lilly & Co. Professional Development Committee Valerie Kuck Public Relations Committee John Schindler Senior Chemists Committee Ken Poggenburg (Chair) Seniors Breakfasts Thomas R. Beattie Women Chemists Committee Valerie Kuck Younger Chemists Committee Jean-François Brazeau (Co-Chair), Celgene Corey Anderson, (Co-Chair), Vertex Pharmaceuticals Voice Mail – San Diego Section

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