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RainDance Technologies Complex Genetics Made Simple TM
Droplet generation for NGS library preparation and dPCR on the RainDrop™: In search of cancer biomarkers Dec 2015 Viviane Sternkopf RainDance Technol...
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Kristina Parsons
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Droplet generation for NGS library preparation and dPCR on the RainDrop™: In search of cancer biomarkers Dec 2015 Viviane Sternkopf
RainDance Technologies Complex Genetics Made SimpleTM
For Research Use Only. Not for Use in Diagnostic Procedures RainDance proprietary information. Not for Distribution.
RainDance Profile Unique Focus, Unified Research Platform
NGS and dPCR
Hereditary Cancers Cancer Pathology Clonal Evolution MRD Monitoring
Rapid Customer Adoption
180 Systems Installed
Strong IP and Technology
Proprietary Digital Droplet Technology Platform
Established Infrastructure
Sales: 15+ countries (Direct/Distributed)
Customers Running >275,000 Samples in 2015
Over 175 Patents and Applications Worldwide
QSR in 2015 Design controls
Leading Customers 2
Tissue and Liquid Biopsy
For Research Use Only. Not for Use in Diagnostic Procedures RainDance proprietary information. Not for Distribution.
120 FTE (25+ PhDs)
Cancer Research Continuum from Screening to Monitoring Tissue Biopsy
Liquid Biopsy
Diseased tissue
Opportunity • Annual biopsies in U.S.: 9 million • Indeterminate results: 15 - 25% • Precious samples: FFPE, FNA, Bone Marrow 3
• • • •
Challenges Sensitivity Cellularity Clonal evolution MRD
For Research Use Only. Not for Use in Diagnostic Procedures RainDance proprietary information. Not for Distribution.
Most Metastatic Tumors Detectable in ctDNA The Opportunity Circulating tumor DNA (ctDNA) detected in most metastatic cancers
Source: Bettegowda et al. Sci Transl Med (2014)
4
The Challenge Circulating tumor DNA detected at low levels in plasma
For Research Use Only. Not for Use in Diagnostic Procedures RainDance proprietary information. Not for Distribution.
Only Unified Platform to Address Cancer Research Continuum • • • • • •
• • • • • • 5
10s to 100s genes Tissue & Liquid biopsy Low input Low VF Research Flexibile content Screening / Low cost Pathology • SNaPshot (NGS) • NGS • TLDA • Arrays, etc.
• Sanger • NGS • LR-PCR • Arrays, etc. 10s to 100s genes Data quality No Sanger confirm CNVs Low VUS Scalability
Hereditary Cancer (NGS)
Clonal Evolution (NGS)
MRD Monitoring (dPCR)
For Research Use Only. Not for Use in Diagnostic Procedures RainDance proprietary information. Not for Distribution.
• • • • • • • • • •
10s genes Liquid biopsy Low VF Low input Fast TAT Low cost RT-qPCR FISH Imaging ELISA
• • • • • • • • • •
Flow RT-qPCR ImmuneSeq ELISA
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