Preliminary Programme EUROPEAN SURGICAL ASSOCIATION

SCIENTIFIC PROGRAMME 18 – 19 APRIL 2008 VENICE

Thursday, 17 April 2008 15:00 – 19:00

REGISTRATION

Friday, 18 April 2008 07:30 – 08:00

REGISTRATION

08:00

PRESIDENT’S WELCOME

08:20

SESSION 1

1

Response-evaluation by endoscopy, re-biopsy, and endoscopic ultrasound does not accurately predict histopathologic regression following neoadjuvant chemoradiation for esophageal cancer 1, 4 1 1 1 1 Schneider Paul M. , Metzger Ralf , Schaefer Hartmut , Baumgarten Frank , Vallböhmer Daniel , 1 1 1 2 3 Brabender Jan , Wolfgarten Eva , Bollschweiler Elfriede , Baldus Stephan E. , Dienes Hans P. , Hoelscher Arnulf H.1 Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany1; Institute of Pathology, University of Düsseldorf, Düsseldorf, Germany2; Institute of Pathology, University of Cologne, Cologne, Germany3, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland4.

2

Radiologic vs. endoscopic evaluation of the conduit after esophageal resection: a prospective, blinded, intraindividual controlled diagnostic study Werner Jens1, Schaible Anja1, Hartwig Werner1, Schneider Lutz1, Strobel Oliver1, Hackert Thilo1, Radeleff Boris2, Sauer Peter3, Richter Götz2, Büchler Markus W.1 Department of General, Visceral, and Transplant Surgery1, Department of Radiology2, Department of Internal Medicine3, University of Heidelberg, Heidelberg, Germany.

3

A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic Beck-Schimmer Beatrice1, Urech Severin1, Breitenstein Stefan2, De Conno Elisena1, Wittlinger Moritz1, Jochum Wolfram3, Puhan Milo4, Graf Rolf2, Spahn Donat1, Clavien Pierre-Alain2 Institute of Anaesthesiology1, Swiss HPB (Hepato-Pancreatico-Biliary) Center, Department of Visceral and Transplantation Surgery2, Institute of Pathology3, Horten Center4, University Hospital, Zurich, Switzerland.

Papers 1 - 5

1

Preliminary Programme 4

Non-invasive preconditioning using erythropoietin improves survival of critically perfused skin by upregulation of NO and VEGF Rezaeian Farid1, Wettstein Reto1, Amon Michaela2, Scheuer Claudia2, Schramm Rene2, Menger Michael D.2, Pittet Brigitte1, Harder Yves1 Division of Plastic, Reconstructive & Esthetic Surgery, University Hospitals of Geneva, Switzerland1; Institute for Clinical & Experimental Surgery, University of Saarland, Homburg/Saar, Germany2.

5

Pancreatico-gastrostomy with gastric partition after pylorus-preserving pancreaticoduodenectomy vs. conventional pancreatico-jejunostomy. A prospective randomized study Fernández-Cruz Laureano1, Cosa Rebeca1, Blanco Laia1, López-Boado Miguel Angel1, Astudillo Emiliano1 Department of Biliopancreatic Surgery, Hospital Clínic1, Barcelona, Spain.

10:00

COFFEE

10:30

SESSION 2

6

Functional results impact of preoperative radiotherapy after colo-anal anastomosis Zalinski Stéphane1, Parc Yann1, Zutshi Massarat2, Remzi Feza2, Ruppert Rienhard3, Fürst Alois4, Celebrezze James5, Galanduik Susan6, Orangio Guy7, Hyman Neil8, Bokey Leslie9, Kirchdorfer Boris3, Medich David5, Tietze Marcus4, Hull Tracy2, Hammel Jeff2, Tiret Emmanuel1, Fazio Victor W.2 Department of Digestive Surgery, Hôpital Saint-Antoine, Université Pierre et Marie Curie, Paris, France1; Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA2; Department of Colorectal Surgery, Krankenhaus München, Neuperlach, München, Germany3; Department of Surgery, Caritas St. Josef Clinic, Regensburg, Germany4; Department of Colorectal Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA5; Department of Colorectal Surgery, University of Louisville, Kentucky, Georgie,USA6; Georgia Colon and Rectal Surgery, Atlanta, Georgia, USA7; Department of Surgery, University of Vermont, Burlington, Vermont, USA8; Department of Surgery, Concord Hospital, Concord, Australia9.

7

Autoexpandable prosthesis implantation in malignant colorectal occlusion achieves better immediate results than emergency surgery: a prospective, randomized, treatment intentionbased study Tejero Eloy1, Lozano Ricardo1, Turégano Fernando2, De Gregorio Miguel A.1, Navarro Ana1, Fernández Luis3 Hospital Lozano Blesa, Zaragoza, Spain1; Hospital Gregorio Marañón, Madrid, Spain2; Hospital Santa Bárbara, Soria, Spain3.

8

Improvement of vascularization of PLGA scaffolds by inosculation of preformed blood vessels with the host microvasculature Laschke Matthias W.1, Rücker Martin2, Jensen Gunnar1, Carvalho Carlos3, Mülhaupt Rolf3, Gellrich Nils-Claudius2, Menger Michael D.1 Institute for Clinical & Experimental Surgery, University of Saarland, Homburg/Saar, Germany1; Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany2; Freiburg Materials Research Center and Institute for Macromolecular Chemistry, Albert-Ludwigs University, Freiburg, Germany3.

9

Impact of KIT and PDGFRA gene mutations on disease-free survival of patients with GIST Weber Frank1, Hou Ying Yong1,3, Li Jun1, Grabellus Florian2, Broelsch Christoph1, Frilling Andrea1 Department of Surgery1, Department of Pathology2, University Hospital Essen, Essen, Germany2; Department of Pathology, Fudan University, Shanghai, China3.

Papers 6 - 11

2

Preliminary Programme 10

Minimal sentinel node (SN) tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients. A multicenter study in 388 SN positive patients van Akkooi Alexander C.J.1, Rutkowski Piotr2, Voit Christiane3, Schaefer Gregor3, Michej Wanda2, de Wilt Johannes H.W.1, Verhoef Cees1, Ruka W.2, Eggermont Alexander M.M.4 Erasmus University Medical Center - Daniel den Hoed Cancer Center, Rotterdam, the Netherlands1; Charité, Humboldt University, Berlin, Germany2; M.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland3; EORTC Melanoma Group, Brussels, Belgium4.

11

Is self-reported quality assessment in surgery reliable? Dindo Daniel1, Hahnloser Dieter1, Hasler Anita1, Schwery Petra1, Clavien Pierre-Alain1 Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland1.

12:30

LUNCH

14:00

BJS LECTURE

14:30

SESSION 3

12

Tacrolimus monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind placebo-controlled study 1 1 1 1 1 Lerut Jan , Mathys Jules , Verbaandert Catherine , Hetsch Nathalie , Talpe Stephanie , Lemaire 1 1 1 1 1 Julien , Vanthuyne Vincent , Ciccarelli Olga , De Reyck Chantal , Gianello Pierre , Goffette Pierre1, Latinne Dominique1, Orlando Giuseppe1, Rahier Jacques1, Sempoux Christine1, Wallemacq Pierre1, Roggen Francine1 Department of Abdominal and Transplantation Surgery – Unit of Abdominal Transplantation, Leuven, Belgium1.

13

Chemotherapy resistance in pancreatic cancer – potential role of cancer stem cells Bruns Christiane1, Ischenko Ivan, Seeliger Hendrik, Camaj Peter, Jauch Karl-Walter Department of Surgery, University of München-Großhadern, LMU München, München, Germany1.

14

Familial pancreatic cancer – results of 5 years of prospective screening of high risk individuals Langer Peter1, Fendrich Volker1, Habbe Nils1, Kann Peter Herbert4, Sina Mercedes2, Slater Emily Prentice1, Rothmund Matthias1, Bartsch Detlef Klaus3 Department of General Surgery1, Institute of Human Genetics2, Philipps-University-Hospital, Marburg, Germany; Department of General Surgery, Städtische Kliniken Bielefeld-Mitte, Bielefeld, Germany3; Division of Endocrinology, Philipps-University-Hospital, Marburg, Germany.4

15

Oesophageal acid-hypersensitivity is not a contraindication for Nissen fundoplication Broeders Joris A.1, Draaisma Werner A.1, Bredenoord Albert J.2, de Vries Durk R.2, Smout André J2, Gooszen Hein G.1 Departments of Surgery1 and Gastroenterology2, Gastrointestinal Research Unit of the University Medical Center Utrecht, Utrecht, the Netherlands.

15:50

COFFEE

16:20

SESSION 4

16

Prognosis of patients with colorectal cancer is associated with the lymph node ratio Rosenberg Robert1, Friederichs Jan1, Gertler Ralf1, Schuster Tibor3, Maak Matthias1, Becker Karen2, Ulm Kurt3, Nekarda Hjalmar1, Höfler Heinz2, Siewert Jörg-Rüdiger1 Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München1, Institut für Pathologie und pathologische Anatomie2, Institut für Medizinische Statistik und Epidemiologie3, München, Germany.

Papers 12 - 15

Papers 16 - 20

3

Preliminary Programme 17

Randomized trial comparing an anterior minimally invasive preperitoneal mesh placement with Lichtenstein approach for primary inguinal hernias Berrevoet Frederik1, De Sutter Stijn1, Troisi Roberto1, Rogiers Xavier1, De Hemptinne Bernard1 University Hospital, Ghent, Belgium1.

18

Predicting systemic recurrence of esophageal cancer after esophagectomy: an international study on the significance of the number of involved lymph nodes Peyre Christian G1, Hagen Jeffrey A.1, DeMeester Steven R.1, Van Lanschot Jan J.2, Hölscher Arnulf3, Law Simon4, Ruol Alberto5, Ancona Ermanno5, Griffin Michael6, Altorki Nassar7, Rice Tom8, Wong John4, Lerut Antoon9, DeMeester Tom R.1 University of Southern California, Los Angeles, USA1; Erasmus Medical Center, Amsterdam, the Netherlands2; University of Köln, Köln, Germany3; University of Hong Kong, Hong Kong, China4; University of Padova, Padova, Italy5; Royal Victoria Infirmary, Tyne & Wear, UK6; Cornell University, Ithaca, USA7; Cleveland Clinic, Cleveland, USA8; University of Ziekenhuizen Leuven, Belgium9.

19

390 laparoscopic Heller-Dor myotomies for achalasia: lessons learned Zaninotto Giovanni1, 2, Costantini Mario1, Rizzetto Christian1, Portale Giuseppe1, Ruol Alberto1, Ceolin Martina1, Guirroli Emanuela1, Finotti Elena1, Zanatta Lisa1, Nicoletti Loredana1, Ancona Ermanno1 University of Padova, Padova, Italy1; U.O. of General Surgery, S. Giovanni e Paolo Hospital ULSS12, Venice, Italy2.

20

Complicated duodenal closure in penetrating ulcer disease – a matched-pair analysis comparing duodeno-jejunostomy, T-drainage and interruption of the gastro-duodenal continuity with “conventional” stump closure Winkler Eva1, Kutup Asad1, Vashist Yogesh1, Thieltges Sabrina1, Schurr Paul1, Kaifi Jussuf1, Izbicki Jakob1, Yekebas Emre1 Department of General, Visceral and Thoracic Surgery, University Medical Center HamburgEppendorf, Germany1.

19:45

Departure to the welcome reception. Meeting points in the main hall of the Hotel Excelsior, Hotel Des Bains, Hotel Belvedere

20:30

WELCOME RECEPTION Monaco et Gran Canal Hotel, St. Mark’s Square

4

Preliminary Programme Saturday, 19 April 2008 07:30 – 8:00

REGISTRATION

08:00

SESSION 5

Papers 21 - 26

21

Going beyond "expanded criteria donors (ECD)": optimal results in renal transplantation using donors over 75 years of age Rigotti Paolo1, Furian Lucrezia1, Baldan Nicola1, Fabris Luca1, Amico Alessandra1, Ekser Burcin1 Department of Surgery and Organ Transplantation, Kidney and Pancreas Transplantation Unit, University of Padua, Padua, Italy1.

22

Response to therapy as main selection criterion for HCC patients waiting liver transplantation Vitale Alessandro1, D’Amico Francesco2, Gringeri Enrico2, Valmasoni Michele2, Brolese Alberto2, Zanus Giacomo2, Carraro Amedeo2, Pauletto Alberto2, D’Amico Davide F2, Cillo Umberto2 Unità di Chirurgia oncologica, IOV-IRCCS, Padova, Italy1; Unità di Chirurgia Epatobiliare e Trapianto Epatico, Università di Padova, Padova, Italy2.

23

Long-term results after laparoscopic versus open hepatectomy for colorectal liver metastases: case-control study between two expert centers Vibert Eric1, Ricca Luana1, Azoulay Daniel1, Adam Rene1, Gayet Brice2, Castaing Denis1 Centre Hépato-Biliaire, Hopital Paul Brousse (AP/HP), Villejuif, France1; Departement de Pathologie Digestive, Institut Mutualiste Montsouris (IMM), Paris, France2.

24

Simvastatin attenuates hepatectomy-induced sensitization to endotoxin via inhibition of HMG CoA reductase Thorlacius Henrik1, Slotta Jan2, Laschke Mattias2, Menger Michael2, Jeppsson Bengt1 Lund University, Lund, Sweden1; University of Saarland, Homburg/Saar, Germany2.

25

The “reversed approach” for patients with locally advanced rectal cancer with synchronous liver metastases Verhoef Cornelis1, van der Pool Anne1, Nuyttens Joost1, Planting Andre1, Eggermont Alexander1, de Wilt Johannes1 Erasmus University Medical Center, Amsterdam, the Netherlands1.

26

Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases Adam René1, Wicherts Dennis A.1, Miller Rafael1, de Haas Robbert J.1, Bitsakou Georgia1, Vibert Eric1, Veilhan Luc Antoine1, Azoulay Daniel1, Bismuth Henri1, Castaing Denis1 Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France1.

10:00

COFFEE SESSION 4

27

Papers 27 - 32

Predicting individual survival after potentially curative esophagectomy for adenocarcinoma of the esophagus or gastroesophageal junction Lagarde Sjoerd1, Reitsma Johannes1, ten Kate Fiebo1, Busch Olivier1, Obertop Hugo2, Zwinderman Aelko1, Moons Johnny3, van Lanschot J. Jan B.2, Lerut Toni3 Academic Medical Centre at the University of Amsterdam, Amsterdam, the Netherlands1; Erasmus Medical Centre Rotterdam, Department of Surgery, Rotterdam, the Netherlands2; Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium3.

5

Preliminary Programme 28

Supplemental eicosapentaenoic acid (EPA) preserves body composition in esophagectomy patients but does not impact on clinical outcome: results of a double-blind randomised clinical trial Reynolds John V1, Ryan Aoife1, Hardie Laura1, Ravi Narayanasamy1, Pidgeon Graham1 St. James’s Hospital, Dublin, Ireland1.

29

Neoadjuvant chemotherapy with gemcitabine/cisplatin for resectable pancreatic cancer generates a significant tumor response – results of a prospective phase II trial Heinrich Stefan1, Schafer Markus1, Weber Achim2, Hany Thomas3, Bauerfeind Peter4, Pestalozzi Bernhard5, Clavien Pierre-Alain1 Swiss HPB (Hepato-Pancreatico-Biliary) Center, Department of Visceral and Transplantation Surgery1, Institute of Pathology2, Nuclear Medicine3, Gastroenterology4, Oncology5, University Hospital, Zurich, Switzerland.

30

Survival is significantly prolonged by adding 18-FDG PET to CTscan and CA 19-9 assay in the follow-up of patients resected for pancreatic cancer Sperti Cosimo1, Berselli Mattia1, Tona Federico1, Pasquali Claudio1, Vicario Giovanni2, Bissoli Sergio3, Chierichetti Franca3, Liessi Guido4, Pedrazzoli Sergio1 Dept. of Medical and Surgical Sciences, IV Surgical Clinic, University of Padua, Padova, Italy1; Departments of Oncology2, Nuclear Medicine3, and Radiology4, Castelfranco Veneto Hospital, Treviso, Italy.

31

Global protein expression profiles by means of serum proteomics reveal significant downregulation of the human hypothalamic satiety factor apolipoprotein A-IV following bariatric surgery Brandacher Gerald1, Golderer Georg2, Klaus Alexander1, Aigner Franz1, Werner Ernst R.2, Lindner Herbert2, Margreiter Raimund1, Weiss Helmut G.1 Department of General and Transplant Surgery1, Division of Biological Chemistry, Biocenter2, Innsbruck Medical University, Austria.

32

Randomized controlled trial of laparoscopic Heller myotomy plus Dor fundoplication vs. Nissen fundoplication for achalasia: long-term results Rebecchi Fabrizio1, Giaccone Claudio1, Farinella Eleonora1, Campaci Roberto1, Morino Mario1 University of Turin, Turin, Italy1.

12:30

LUNCH

14:00

PRESIDENTIAL ADDRESS

14:30

SESSION 7

33

Adjuvant intra-arterial chemotherapy and radiotherapy vs. surgery alone in resectable pancreatic and periampullary cancer. A prospective randomized controlled trial. 1 2 3 4 5 Morak Marjolein , van der Gaast Ate , Nuyttens Joost , van Dekken Herman , Hermans John , 1 6 1 1 Jeekel Johannes , Hop Wim , Kazemier Geert , van Eijck Casper Department of Surgery1, Department of Oncology2, Department of Radiotherapy3, Department of Pathology4, Department of Radiology5, Department of Statistics6, Erasmus Medical Center, Rotterdam, the Netherlands.

34

Donor treatment with steroids reduces inflammation and improves graft function and outcome following deceased liver transplantation - a prospective randomized trial Pratschke Johann1, Kotsch Katja2, Ulrich Frank1, Reutzel-Selke Anja1, Pascher Andreas1, Faber Wladimir1, Warnick Peter1, Hoffman Sophia1, Francuski Maja1, Kuecuek Onur4, Schumacher Guido1, Wesslau Claus4, Lun Andreas3, Kohler Sven1, Weiss Sascha1, Tullius Stefan5, Neuhaus Peter1 Dept. of General-, Visceral- and Transplantation Surgery1, Dept. of Immunology2, Dept. of Hematology3, Charité, Berlin, Germany; Deutsche Stiftung Organtransplantation, Berlin, Germany4; Division of Transplant Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA5.

Papers 33 - 36

6

Preliminary Programme 35

Abdominal drains in liver transplantation: useful tool or useless dogma? A matched casecontrol study de Rougemont Olivier1, Dutkowski Philipp1, Petrowsky Henrik1, Weber Markus1, Clavien PierreAlain1 Swiss HPB (Hepato-Pancreatico-Biliary) Center, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland1.

36

[18F]-fluorodeoxyglucose-positron emission tomography does not accurately predict histopathological response or prognosis following neoadjuvant chemoradiation for esophageal cancer Vallböhmer Daniel1, Hölscher Arnulf H.1Dietlein Markus2, Bollschweiler Elfriede1, Baldus Stephan E.3, Mönig Stefan P.1, Metzger Ralf.1, Schneider Paul M.1, 4, Schicha Harald2, Schmidt Matthias2 Department of Visceral and Vascular Surgery1, Department of Nuclear Medicine2, University of Cologne, Cologne, Germany; Department of Pathology, University of Düsseldorf, Düsseldorf, Germany3; Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland4.

16:00

GENERAL ASSEMBLY

19:45

Walk to the Hotel Excelsior: meeting point in the main hall of the Hotel Des Bains. In addition, there is a shuttle from the congress hotels to the Hotel Excelsior.

20:30

GALA DINNER Hotel Excelsior, Lido

7