MESOTHERAPY + THE RIGHT PHYSICIAN = FAT LOSS, CELLULITE REDUCTION, ANTI-AGING…..

IN THIS REPORT: WHAT IS MESOTHERAPY? WHAT -

CAN MESOTHERAPY TREAT? Fat Loss Cellulite Reduction Hair Loss/Alopecia Face & Neck Skin Rejuvenation Body Sculpting

WHAT IS LIPODISSOLVE? HOW DOES IT WORK? HOW MANY TREATMENTS DO I NEED? RESEARCH STUDIES MESOTHERAPY – Q&A TIPS FOR FINDING THE RIGHT DOCTOR CONTACT DETAILS

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WHAT IS MESOTHERAPY? Pioneered by the French physician, Dr. Michel Pistor in 1952, Mesotherapy is a non-surgical, relatively painless injection technique with a broad range of applications. Mesotherapy promotes the body’s circulatory, lymphatic, and immune system to create a biological response and reverse abnormal physiology. Mesotherapy involves the injection of a customized mixture of vitamins, amino acids, and medications, placed just millimeters under the skin into the problematic area. Just a “drop” of solution is used at each injection site. WHAT CAN MESOTHERAPY TREAT? Mesotherapy is an interventional injection technique that is safe and effective treatment for fat, cellulite, hair loss (alopecia), anti-aging, skin tightening and skin rejuvenation. Unlike surgical procedures such as liposuction, Mesotherapy is virtually painless, requires no post-operative recovery time, requires no heavy bandages or girdles, and no anesthesia is necessary. While many surgical procedures require one to two weeks of recovery, patients undergoing Mesotherapy have no interruptions to their daily life, while obtaining a natural cosmetic rejuvenation. The results obtained with Mesotherapy do vary from patient to patient but can be very dramatic. After completing a series of Mesotherapy treatments, generally over a three month period of time, patients can notice improvement in skin quality, less dimpling of the skin & weight reduction… Fat Loss: Patients who are seeking fat loss, particularly in isolated “trouble apots”, may find Mesotherapy very beneficial. The biology of the fat cell is modified by blocking the signals of fat accumulation and simultaneously triggering the release of stored fat. Again, the desired area of treatment can be patient specific, targeting your most problematic areas. Additionally, a complete dietary and nutrient evaluation will help you maintain your weight loss goals. For more information on Mesotherapy and Fat Loss please read the section in this report on “Lipodissolve”. Cellulite Reduction: Cellulite affects the majority of women over the age of 20. Poor circulation, fat herniation, a weakening of connective tissues, lymphatic congestion and hormonal imbalances can all be at fault for the development of cellulite. Cellulite is classified into four stages, based upon its appearance while standing, laying, and pinching the skin. Causing a dimpling and cottage cheese appearance of the skin, cellulite is not a disease of excess weight. Mesotherapy treatment is targeted to correct these problems by improving circulation, strengthening connective tissues, and dissolving excess fat. Hair loss/Alopecia: The loss of hair, affects both men and women. Alopecia results from poor circulation, nutritional imbalances, and the excess of a hormone known as DHT (dihydrotestosterone). Mesotherapy can correct these problems, stimulating the body to naturally grow lost hair. Face & Neck Skin Rejuvenation: Aging, sagging and wrinkling of the skin occurs from accumulation of fat, loss of skin elasticity and excessive free radical damage. Using antioxidants and amino acids, Mesotherapy can remove fat from under the neck, remove free radical damage, and tighten loose skin. The effects rejuvenate the face, eyelids, and neck without the unnatural appearance and painful recovery of surgical face lifting.

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Body Sculpting: Contouring of the abdomen, arms, back, legs and hands can be obtained with Mesotherapy. Vitamins and amino acids are used to tighten sagging skin while other agents are used to remove areas of fat, restoring a more youthful and athletic appearance to the body’s contours. WHAT IS “LIPODISSOLVE”? “Lipodissolve” injections essentially are injections containing Phosphatidylcholine as the main ingredient. These injections should not be regarded as a new “miracle drug” for weight reduction, however, in the case of fat deposits which cannot be removed by diet or exercise then PPC injections are effective. The injections do this by helping the natural metabolic process during which fat is melted away and then eliminated from the body. The medication is directly injected into the area concerned. Areas suitable for treatment are: Double Chin, Cheeks, Eye Fat Pads, Buttocks, Thighs, Love Handles, Waist, Back, Hips, Stomach, Upper Arm, Knee and Elbow Joints… HOW DOES IT WORK? Phosphatidylcholine is a natural chemical which acts in the body to protect the liver, and has also been used by doctors for many years to prevent fat embolism in the blood. The biology of the fat cell is modified by blocking the signals of fat accumulation and simultaneously triggering the release of stored fat. The customized formula containing the PPC is injected in a specific area blocks the cells from storing fat and helps break the existing fat cells down. The body then naturally flushes out the broken-down fat. HOW MANY TREATMENTS DO I NEED? The number of treatments differs from person to person, depending upon body region and body size. As a rule, 2 – 6 treatments in intervals of 3 – 6 weeks are necessary to successfully complete the treatment. FROM THE EXPERTS - RESEARCH STUDIES Hexsel D. - “Phosphatidylcholine in the treatment of localized fat”: The Journal of Drugs and Dermatology - 2003 One study relating to Phosphatidylcholine (the active ingredient in Mesotherapy injections for localised fat) in the treatment of localised fat reported that out of the 208 patients with different patterns of localised fat on the body (thighs, hips, abdomen, flanks) and face (chin) were treated between July 2001 to December 2002 reported that: • • •

Discomfort after treatment was limited to moderate to severe edema, erythema and localised heat. While some points showed bruises these regressed spontaneously after 7-10 days Discomfort was slight and moderate itching was reported by some participants Very few patients failed to notice reduction in the subcutaneous thickness

The study also concluded that PPC was shown to be “efficacious and safe” & “low cost and easy” compared to surgery. Guedes Rittes P. - “The Use of Phosphatidylcholine for Correction of Lower Lid Bulging Due to Prominent Fat Pads”: The American Society for Dermatologic Surgery Inc - 2001 Thirty patients were treated for prominent lower eyelid fat pads with Phosphatidylcholine injections. Pre and post treatment photographs were taken for long term analysis. The study reported that: • Cosmetic improvement occurred in all patients • All patients complained of mild burning following injections, which typically only lasted about 15 minutes • A marked reduction of the lower eyelid fat pads with no recurrences. These images taken from the study which develop the visual improvements:

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PATIENT - QUESTIONS & ANSWERS WHAT AREAS OF THE BODY CAN BE TREATED WITH MESOTHERAPY? Love handles, Stomach, Saddle bags, Bra bulge, Inner thigh bulge, Buttocks, Abdomen, Knee pads, Double chin, Face and neck, Arms, Back, Legs, Hands and Waist. WHO IS SUITABLE FOR MESOTHERAPY? Most healthy adults 18 to 80 may have Mesotherapy for body sculpting, cellulite treatment, skin rejuvenation and alopecia. The exclusion criteria as a guide follows but each patient must be assessed individually to determine whether the exclusion criteria apply for the treatment they seek. WHO IS UNSUITABLE FOR MESOTHERAPY? Pregnancy, patients who are on blood thinners, insulin dependent diabetics, patients with cancer or in remission, patients with AIDS, patients, AIDS patients, patients with coronary artery heart disease or heart dysfunction, People with arrhythmias, with a history of blood clots or strokes, patients with autoimmune diseases or organ transplant recipients and patients with skin conditions including: herpes & psoriasis… HOW FAST WILL THE PATIENT SEE RESULTS? The speed of results depends on the area treated and the extent of the problem. Fat pads of the eye will usually show visible improvement after the first 1- 2 treatments. Cellulite and fat should show visible improvement after 2 – 4 treatments. MesoLift procedures show visible results within 1 – 2 days after the first treatment. WILL THE RESULTS LAST? It must not be forgotten that the effect of most procedures, although long-lasting, does fade with time. Therefore wise to recommend maintenance treatment at the rate of approximately one session a month. For the results gained from localized fat removal to be permanent requires the patient maintains their weight. A regular exercise regime, including cardio and resistance training and the implementation of a healthy diet, that places emphasis on lean protein and low G.I carbohydrates, will assist patients in maintaining results. HOW LONG IS THE “DOWN TIME” AND RECOVERY TIME? There is no down time or recovery time for this procedure. The patient will be back to regular activities immediately. ARE THE TREATMENTS PAINFUL? The majority of patients experience minimal discomfort. For those who have discomfort, a topical anesthetic cream can be utilized 45 minutes prior to the procedure. Ice can also be applied prior to or after the procedure if necessary. DOES MESOTHERAPY REPLACE LIPOSUCTION? In many cases Mesotherapy offers an alternative to even the safest form of liposuction, tumescent liposuction, (see table below). Tumescent liposuction has been recognized world wide as the technique permitting the greatest safety, the most rapid recovery, the least pain and the best aesthetic results. While tumescent liposuction offers superior safety and result its important to remember tumescent liposuction can only be handled by the hands of an expert surgeon. Mesotherapy is a non-invasive alternative supported by a 1994-95 study on "topical fat reduction" by UCLA researchers. This study concluded women who had Mesotherapy injections lost weight even without diet or exercise. About 100 people a year die because of liposuction, Mesotherapy has no deaths, stokes or heart attacks. A patient’s major concern with Mesotherapy is simple bruising and liver toxicity. Liposuction Surgical Procedure Removes Fat Cells Cannot Be Used Where There is Cellulite Down Time = 2 weeks+ Restrictive Garments - Post-Operation for Weeks Weight Gain Back in Abnormal Places Appearance of Cellulite and Dimpling Common Significant Bruising and Pain

Mesotherapy Non-Invasive Procedure Removes Fat from the fat Cells Used Wherever There is Cellulite No Down Time Wear Loose Clothing After Treatment Weight Gain Back Where it Lost Cellulite Eliminated and Maintained with Diet Minimal Bruising and Pain

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HOW TO FIND A GREAT MESOTHERAPY PHYSICIAN As with any potential doctor, when you are looking for a new physician it is important to find someone who is not only qualified but also friendly and personable. A good Mesotherapy doctor should be willing to answer all of your questions about Mesotherapy and will take the time to make sure you completely understand everything you need to know. A good Mesotherapy doctor should be capable of answering all of your questions about the treatment A good Mesotherapy doctor will not only have a license to practice Mesotherapy but they should also have certification with specific training in Mesotherapy. A good Mesotherapy doctor should be willing to give you a list of the medications that they intend to use during treatment. A good Mesotherapy doctor can offer you written testimonials from patients who they have administered Mesotherapy to – or even a list of patients who have received treatment are willing to talk with you.

SHOULD YOU REQUIRE ADDITIONAL INFORMATION PLEASE CALL MESOTHERAPY WORLDWIDE ON +61 2 9439 7781 or email us at [email protected]

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The information regarding procedures or results of Mesotherapy presented in this document has been compiled with all care and presented for educational purposes only, and is not intended to represent the only, nor necessarily the best, methods or procedures appropriate for the medical situations. While Mesotherapy Worldwide (MW) endeavors to ensure that the information provided is accurate and current, it accepts no responsibility for any errors or omissions. MW disclaims all responsibility and all liability (including, without limitation, liability in negligence) for all expenses, losses, damages (including, without limitation, direct, indirect, punitive, special or consequential) and costs you might incur as a result of the information being inaccurate or incomplete in any way, and for any reason.

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