MARY MICHELE MARISCALCO, M.D., FAAP, FCCM Curriculum Vitae August 2011

CURRENT TITLE AND ADDRESS: Professor of Pediatrics Associate Dean for Research KU School of Medicine – Wichita 1010 North Kansas Wichita, KS 67214 66214 Phone 316-293-3439 FAX 316-293-2686 DATE OF BIRTH: June 13, 1955 EDUCATION: Undergraduate

University of Dayton; Dayton, Ohio Bachelor of Science, Summa Cum Laude 1973 - 1977

Medical School

Univ. of Cincinnati College of Medicine, Cincinnati, Ohio Doctor of Medicine 1977 - 1981

POSTGRADUATE EDUCATION: Internship & Res.

Pediatrics Department of Pediatrics, Baylor College of Medicine June 1981 - July 1984

Fellowship

Pediatric Critical Care Medicine Department of Pediatrics Baylor College of Medicine, Houston, TX July 1984 - June 1986

CERTIFICATION: Diplomate

LICENSURE:

American Board of Pediatrics, 1986 American Board of Pediatrics, Sub-board Critical Care Medicine, 1987 Re-certified 1995, 2001 Texas, 1984 #G7272 Ohio, 1981 #35-04-6632

PROFESSIONAL SOCIETIES: American Academy of Pediatrics Fellow of the American Academy of Pediatrics 2000 Society of Critical Care Medicine Fellow of the American College of Critical Care Medicine 2008 Elected to American Pediatric Society January 2009 American Thoracic Society APPOINTMENTS: Academic Professor of Pediatrics Associate Dean for Research KU School of Medicine – Wichita Wichita, KS 2010-present Adjunct Research Professor of Pediatrics Baylor College of Medicine Houston, TX 2010-present Professor of Pediatrics (Tenured) Section of Critical Care Medicine Baylor College of Medicine, Houston, Texas, 2006 – 2010 Director, Fellowship Research Associate Director, Pediatric Critical Care Medicine Fellowship Program Section of Critical Care Medicine Baylor College of Medicine, Houston, Texas, 2002 – 2010t Residency Review Committee 1990-present Department of Pediatrics Baylor College of Medicine, Houston, Texas 77030 Chairman Institutional Review Board for Human Experimentation - #2 and #5 2004-2008 Baylor College of Medicine, Houston, Texas 77030 Director, Pediatric Critical Care Medicine Fellowship Program Baylor College of Medicine, Houston, Texas, 1997 - 2002 Assistant Professor of Pediatrics Section of Critical Care Medicine Baylor College of Medicine, Houston, Texas, 1986 – 2006 APPOINTMENTS : Clinical Chairman : Cardiopulmonary Resuscitation Committee

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 3 of 17

Texas Childrens Hospital : July 2008-September 2010 Associate Staff, Intensive Care Service Texas Children's Hospital Houston, Texas, 1986 – September 2010 Scientific Advisory Committee to the General Clinical Research Center 1995-2010 Baylor College of Medicine, Houston, Texas 77030 Acute Chest Guideline and Implementation Committee: Texas Children's Hospital Houston, Texas December 2007 – September 2010 Status Epilepticus Guideline and Implementation Committee: Texas Children's Hospital Houston, Texas December 2008 – September 2010 APPOINTMENTS: National Subboard of Pediatrics Critical Care Medicine, American Boards of Pediatrics, 2005 – 2010 Chairman: Subboard Pediatric Critical Care Medicine 2009-2010 National Advisory Committee, Pediatric Critical Care Scientist Development Program (1K12 HD047349-01 J. Michael Dean, Principle Investigator) 2004-present AWARDS: 2011 Distinguished Alumni Award National Alumni Association University of Dayton, Dayton, Ohio Society of Critical Care Medicine 2010 Barry A. Shapiro Memorial Award for Excellence in Critical Care Management 2009 Award of Excellence in Teaching in Research July 2008-June 2009 Department of Pediatrics, Baylor College of Medicine Pediatric Award for Excellence in Teaching July 1993 - June 1994 Department of Pediatrics, Baylor College of Medicine Pediatric Housestaff Teaching Award Staff Attending, 1987 Department of Pediatrics, Baylor College of Medicine

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 4 of 17

Pediatric Housestaff Teaching Award Clinical Fellow, 1986 Department of Pediatrics, Baylor College of Medicine

COMMITTEE MEMBERSHIPS –NATIONAL /INTERNATIONAL: Committee of the Pediatric Critical Care Medicine Fellowship Directors Society of Critical Care Medicine EDITORIAL BOARDS Pediatric Critical Care Medicine 2005-2014 AD-HOC REVIEWER FOR THE FOLLOWING : Pediatrics Blood Journal of Leukocyte Biology Pediatric Research Archives of Pediatrics and Adolescent Medicine Critical Care Medicine Pediatric Critical Care Medicine Thrombosis and Hemostasis

INVITED CONFERENCES AND WORKSHOPS: International 1.

T-Cells from Cord Blood have Increased Adhesion to Stimulated Endothelial Cells Compared to Adult. 3rd World Congress of Pediatric Critical Care Medicine Montreal, Canada June 2000

2. Care of the Immunocompromised Host in the ICU – 1st MesoAmerican and Caribbean Congress of Pediatrics – Guatemala City, Guatemala, July 19, 2005 3. Septic Shock - 1st MesoAmerican and Caribbean Congress of Pediatrics – Guatemala City, Guatemala, July 20, 2005 4. What Every Pediatrician Should Know About Inflammation - 1st MesoAmerican and Caribbean Congress of Pediatrics – Guatemala City, Guatemala, July 20, 2005

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 5 of 17

5. How to start a successful career in Pediatric Critical Care Medicine. 38th Critical Care Congress . Nashville, TN. January 31, 2009 6. “Multiple Organ Dysfunction Syndrome” Xth Latin American Congress of Pediatric Critical Care Medicine. Guatemala City, Guatemala, April 28, 2010. 7. “What we have learned in 35 years of Pediatric Critical Care Medicine”. Xth Latin American Congress of Pediatric Critical Care Medicine. Guatemala City, Guatemala, April 28, 2010. National: 1.

Effect of Lipopolysaccharide on circulating neutrophil CD18 integrin and Lselectin expression “Pediatric Colloquium Snowbird, Utah, January 1992

2.

"Leukocyte and the Inflammatory Response" First World Congress of Pediatric Critical Care, Baltimore, Maryland - June 1992

3.

Society for Critical Care medicine, 22nd Educational And Scientific Symposium Moderator: Pediatric Basic Science Session, New York, NY – June 1993

4. "Neutrophils, Host Defense and Inflammation" National Institute of HealthCritical Care Medicine Department, Bethesda, Maryland, March 24, 1995 5. Society for Critical Care Medicine, 27th Educational and Scientific Symposium: Cell Adhesion Molecules in Multi-Organ Failure, San Antonio, Texas, February 5, 1998. 6. “Leukocyte Endothelial Interactions Symposium” Co-Chair - Experimental Biology, April 2000, San Diego, CA. 7. Pediatric Critical Care Poster Symposium, Co-Chair – American Thoracic Society, Toronto, Ontario, May 2000 8. L-selectin dependent leukocyte localization is diminished in neonatal rabbits in vivo, Experimental Biology 2000 San Diego California April 16, 2000 9. Ontogeny of Mac-1 dependent leukocyte localization in a rabbit model, Experimental Biology 2001 Orlando Florida April 1 2001 10. “Leukocyte Localization in the Developing Host” Alfred I. DePont Hospital for Children Wilmington, Delaware November 2001

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11. Diminished P-selectin-dependent tether duration contributes to depressed neonatal neutrophil-platelet interactions, Experimental Biology 2002, New Orleans Louisiana, April 24 2002 12. “Pediatric Year in Review” 32nd Critical Care Congress, Society of Critical Care Medicine, January 30, 2003; San Antonio, Texas 13. “Pediatric Neuromuscular Injury” Rehabilitation of the Paralyzed Limb, Clinical Challenges and Scientific Solutions, First Symposium of the Center for Tissue Repair, Regeneration and Engineering entitled, Houston, Texas February 6, 2004 14. “TNF but not IFNγ stimulation of EC results in increased neonatal T cell motility under shear.” Experimental Biology 2005, San Diego, California, April 2, 2005 Local 1. Update on the Management of Patients in Multi-Organ Failure” Pediatric Anesthesiology Section, Baylor College of Medicine, Houston, Texas February 26, 2008 2. “Designing an Ethical Research Study: the federal regulations and the IRB.” Texas Children's Hospital Bioethics Retreat. June 12, 2009. 3. “Improving health care for all: New opportunities for research and innovation in Wichita.” 62nd Annual WMREF Meeting . April 27, 2010. Wichita , Kansas 4. “Quality Improvement vs Research” IRBs & Research: Prime Time Topics, September 30, 2011. Wichita, Kansas COURSES: 1)

Acute Care Pediatrics Review and Update Hilton Head North Carolina Co-Director 1987 Director 1993 Baylor College of Medicine, Department of Pediatrics

2)

Multi-Disciplinary Critical Care Board Review Course Organizational Committee San Diego, California August 1995 Society for Critical Care Medicine

3)

2nd-5th Annual Fellows Days Organizational Committee 1999- 2004

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 7 of 17

Director 2001 & 2002 Department of Pediatrics, Baylor College of Medicine RESEARCH INFORMATION 1.

Research Training in Pediatric Critical Care Medicine :National Research Service Award – NHLBI (Active) Principal Investigator 07/01/2000 – 08/31/2013 Contract: 5 T32 HL07939 - This grant is a T32 training grant for both MDs and PhDs to train in research areas that are under investigated in the developing critically ill child, outside the neonatal age range.

2.

Leukocyte Trafficking: From Flowing Blood to Tissue - Consortium (Completed) NIH/NHLBI Co-Investigator 09/29/03 – 08/31/08 Contract: 1 RO1 HL070537-01A1 - This grant will use bioengineering principles to study the mechanisms of leukocyte transmigration and tissue injury.

3.

PMN Motility and Adherence in Neonates (Completed) NIH/NIAID Co-Investigator 07/1995 – 06/2001 Overall Period: $949,286 Contract: ROI AL 19031-13 - The goal of this project is to evaluate/identify changes in neonatal neutrophil function that contributes to developmentally diminished ability of neonate’s to fight infection

ARTICLES: (Refereed Journals) 1)

Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Schmalstieg FC, Anderson DC. Recognition of an Endothelial Determinant for CD18-Dependent Human Neutrophil Adherence and Transendothelial Migration. J Clin Invest 1988; 82:1746-1756

2)

Romero LA, Mariscalco MM, Fortenberry JD, Timmons OD. Effect of Serum and Endotoxin in Experimental Lung Injury. J Pediatr Surg 1990; 25:846-849.

3)

Griggs JR, Bricker JT, Mariscalco MM, Jefferson LS, Langston C. Back pain with Cardiovascular Collapse in a Pediatric Emergency Department. Pediatric Emergency Care 1990; 6:17-20.

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 8 of 17

4)

Fortenberry JD, Mariscalco MM, Louis PT, Stein F, Jones JK, Jefferson LS. Severe Laryngotracheobronchitis Complicating Measles in Children. Amer. J. Dis Child 1992; 146:1040-1043.

5)

Feltes TF, Pignatelli R, Kleinert S, Mariscalco MM. Quantitated Left Ventricular Systolic Mechanics in Children with Septic Shock Utilizing Non-Invasive Wall Stress Analysis. Critical Care Medicine, 1994; 22:1647-1658.

6)

Fortenberry JD, Marolda JR, Anderson DC, Smith CW, Mariscalco MM, CD18Dependent and L-Selectin-Dependent Neutrophil Emigration is Diminished in Neonatal Rabbits. Blood 1994; 84:889-897.

7)

Rivera-Matos IR, Rakita RM, Mariscalco MM, Elder FF, Dreyer SA, Cleary TG. Leukocyte Adhesion Deficiency Mimicking Hirschsprung’s Disease. (Review) Journal of Pediatrics 1995; 127:755-757.

8)

Graf JM, Smith CW, Mariscalco MM. Contribution of LFA-1 and Mac-1 to CD18Dependent Neutrophil Emigration in a Neonatal Rabbit Model. Journal of Applied Physiology, 1996; 80:1984-1992.

9)

Perez RG, Arai M, Richardson C, DiPaula A, Siu C, Matsumoto N, Hildreth JE, Mariscalco MM, Smith CW, Becker LC. Factors Modifying Protective Effect of AntiCD18 Antibodies on Myocardial Reperfusion Injury in Dogs. American Journal of Physiological Society 1996; 270:H53-H64.

10)

Mariscalco MM, Tcharmtchi MH, Smith CW. P. Selectin Support of Neonatal Neutrophil Adherence Under Flow: Contribution of L-Selectin, LFA-1, and Ligand(s) for P-Selectin. Blood 1998; 91:4776-85.

11)

Proulx F, Turgeion JP, Litalien C, Mariscalco MM, Robitaille P, Seidman E. Inflammatory Mediators in Escherichia coli 0157:H7 Hemorrhagic Colitis and Hemolytic-uremic Syndrome. Pediatric Infectious Disease Journal 1998; 17:899-904.

12)

Proulx F, Seidman E, Mariscalco MM, Lee K, Caroll S. Increased Circulating Levels of Lipopolysaccharide Binding Protein in Children with Escherichia coli 0157:H7 Hemorrhagic Colitis and Hemolytic Uremic Syndrome. Clinical and Diagnostic Laboratory Immunology 1999, 6:773.

13)

Rakita RM, Vanek NN, Jacques-Palaz K, Mee M, Mariscalco MM, Dunny GM, Snuggs M, VanWinkle WB, Simon SI. Enterococcus Fecalis Bearing Aggregation Substance is Resistant to Killing by Human Neutrophils Despite Phagocytosis and Neutrophil Activation. Infection and Immunity, 1999; 67:6067-6075.

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 9 of 17

14)

Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon JP, Orrbine E, Rowe PC, McLaine PN, Seidman E. Circulating Inflammatory cytokine levels Hemolytic Uremic Syndrome. Pediatric Nephrology, 1999; 13:840-5.

15)

Vanek NN, Simon SI, Jacques-Palaz K, Mariscalco MM, Dunny GM, Rakita RM. Enterococcus Faecalis Aggregation Substance Promotes Opsonin-independent Binding to Human Neutrophils via a Complement Receptor Type 3-mediated Mechanism. FEMS Immunology and Medical Microbiology, 1999; 26:49-60.

16)

Tcharmtchi MH, Smith CW, Mariscalco MM. Neonatal Neutrophil Interaction with PSelectin: Contribution of P-Selectin Glycoprotein Ligand-1 and Sialic Acid. Journal of Leukocyte Biology, 2000;67:73-80.

17)

Proulx F, Litalien C, Turgeon JP, Mariscalco MM, Seidman E. Circulating Levels of Transforming Growth Factor-Beta 1 and Lymphokines among Children with Hemolytic Uremic Syndrome. American Journal of Kidney Disease, 2000;35:29-34.

18)

Buteau C., Proulx F., Chaibou M., Raymond D., Clermont MJ, Mariscalco MM, Lebel ML, Seidman E: Leukocytosis in Children with Escherichia coli 0157:H7 Enteritis Developing the Hemolytic-Uremic Syndrome. Pediatric Infection Disease Journal, 2000;19:642-7.

19)

Masi C., Proulx F, Toledano B., Clermont MJ, Herbert MJ, Mariscalco MM, Seidman E, Carcillo J: Soluble Fas and Soluble Fas-Ligand in Children with Escherichia coli 0157:H7 Associated Hemolytic Uremic Syndrome. American Journal Kidney Disease, 2000; 36:687-94

20)

Mariscalco MM, Vergara W, Mei J, Smith EO, Smith CW, Mechanisms of Decreased Leukocyte Localization in the Developing Host: American Journal of Physiology Heart and Circulatory Physiology 2002, 10.1152/ajpheart.00090.2001

21)

Proulx F, Toledano B, Phan V, Clermont MJ, Mariscalco MM, Seidman EG. Circulating granulocyte colony-stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli )157;H7 associated hemolytic uremic syndrome. Pediatric Res 2002 Dec; 52(6):928-34

22)

Decaluwe H, Harrison LM, Mariscalco MM, Gendrel D, Bohuon C, Tesh VL, Proulx F. Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res. 2006 Apr;59(4 Pt 1):579-83

23)

Shafi NI, Mariscalco MM, Considering the use of induced hypothermia in a pediatric patient with traumatic brain injury: A critical appraisal of two meta-analyses. Pediatric Crit Care Med. 2006 Sept;7(5):468-72

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 10 of 17

24)

Thammasitboon S, Mariscalco MM, Yudkowsky R, Hetland MD, Noronha PA, Mrtek RG. Exploring Individual Opinions of Potential Evaluators in a 360-degree Assessment: Four Distinct Viewpoints of a competent Resident. Teaching and Learning in Medicine 2008; 20(4):314-22

25)

Desai MS, Mariscalco MM, Tawil A, Vallejo JG, Smith CW. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol. 2008 Jun;83(6):1336-44 Epub 2008 Mar 11

26)

Storm SW, Mariscalco MM, Tosi MF. Postnatal maturation of total cell content and upregulated surface expression of Mac-1 (CD11b/CD18) in polymorphonuclear leukocytes of human infants. J Leuko Biol 2008 May 21 (Epub ahead of print).

27)

Proulx F. Joyal JS, Mariscalco MM, Leteurtre S, Leclerc F, Lacroix J. The Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med. 2009 Jan;10(1):12-22

28)

Grierley J, Choong K, Cornell T, Decaen A, Deymann A, Doctor A, Davis A, Duff J, Dugas MA, Duncan A, Evans B, Feldman J, Felmet K, Fisher G, Frankel L, Jeffries H, Greenwald B, Gutierrez J, Han K, Hanson J, Hazelzet J, Hernan L, Kiff J, Kissoon N, Kon A, Irazusta J, Lin J, Lorts A, Mariscalco M, Mehta R, Nadel S, Nguyen T, Nicholson C, Peters M, Okhuysen-Cawley R, Poulton T, Relves M, Rodriguez A, Rozenfeld R, Schnitzler E, Shanley T, Skache S, Skippen P, Torres A, von Dessauer Chile B, Weingarten J, Zaritsky A, Stojadinovic B, Zimmerman J, Zuckerberg A. 2007 American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock Crit Care Med. 2009 Feb;37(2):666-88.

29)

Velasquez MP, Mariscalco MM, Goldstein S, Airewele G. Erythrocytapheresis in children with sickle cell disease and acute chest syndrome. Pediatr Blood Cancer. 2009 Dec;53(6):1060-3.PMID: 19637317 (Epub ahead of print. 2009 Jul 27).

30)

Typpo, K, Petersen N, Hallman DM, Markovitz B, Mariscalco M. Day One MODS is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatr Crit Care Med. 2009 Sep;10(5):562-70.PMID: 19741445

31)

Typpo KV, Petersen NJ, Petersen LA, Mariscalco MM. Children with Chronic Illness Return to Their Baseline Functional Status After Organ Dysfunction on the First Day of Admission in the Pediatric Intensive Care Unit. J Pediatr. 2010 Jul;157(1):108-113.e1. Epub 2010 Mar 10.PMID: 2022347

32)

Crabtree EA, Mariscalco MM, Hesselgrave J, Iniquez SF, Hilliard TJ, Katkin JP, McCarthy K, Velasquez MP, Airewele G, Hockenberry MJ . Improving care for children with sickle cell disease/acute chest syndrome. Pediatrics. 2011 Feb;127(2):e480-8. Epub 2011 Jan 17. PMID 212422

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 11 of 17

REVIEWS: (Peer Reviewed) 1)

Mariscalco MM, Is plasma procalcitonin ready for prime time in the pediatric intensive care unit? Pediatr Crit Care Med. 2003 Jan; 4(1):118-9, Vol 4, No. 1

2)

Mariscalco MM, More than skin deep? Complications associated with vasopressin infusion: a cautionary tale.Crit Care Med. 2003 May;31(5):1587-8. Review.

3)

Mariscalco MM, Hepatic microcirculation in ischemia/reperfusion: is there a role for poly(adenosine 5'-diphosphate-ribose) polymerases? Crit Care Med. 2004 Feb;32(2):605-7

4)

Alten J, Mariscalco MM. Critical appraisal of Perez et al. Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med. 2005 Jul;6(4):480-2. Mariscalco MM. Hyperglycemia in children: unique challenges…unanswered questions. Pediatr Critical Care Med 2005 Jul;6(4):498- 9

5)

6)

Mariscalco MM Unlocking (perhaps unblocking) the microcirculation in sepsis.Crit Care Med. 2006 Feb;34(2):561-2

7)

Mariscalco MM. HBP – another neutrophil granule protein…another new biomarker? Crit Care Med 2011 Apr; 34(4):910-911 PMID 21613851

REVIEWS: (Non-Peer Reviewed) 1)

Mariscalco MM. Leukocytes and the Inflammatory Response. Critical Care Medicine 1993; 21:S347.

2)

Zimmermann JJ, Kochanek PM, Meadow W, Mariscalco MM. Molecular Pathophysiology in Critical Care Illness. Critical Care Medicine 1993;21:S400.

3)

Mariscalco MM. Critical Care of the Immunocompromised Host. Semin Pediatr Infect Dis 1992;3:235-243.

4)

Abbassi O, Mariscalco MM, McEver R., McIntire LV, and Smith CW. Effects of Shear Stress on Leukocyte Adhesion. In: Metcalf BW, Dalton BJ and Poste G, eds. Cellular Adhesion: Molecular Definition to Therapeutic Potential, New York, Plenum Press, 1994:135-151.

5)

Mariscalco MM, Smith CW. Adhesion Molecules and Tissue Injury. In Current Topics in Intensive Care #3, P. Dellinger ed, W.B. Saunders Co Ltd, London 1996:102-130

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 12 of 17

6)

Mariscalco MM Innate immunity in critical care. Semin Pediatr Infect Dis. 2006 Jan;17(1):25-35. Review.

BOOK CHAPTERS: 1)

Mariscalco MM General Principles. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:775-778.

2)

Mariscalco MM Salicylism. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:778-780.

3)

Mariscalco MM Acetaminophen Overdose. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:780-782

4)

Mariscalco MM Plant Poisoning. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:782-783.

5)

Mariscalco MM Shock. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:996-999

6)

Mariscalco MM Adult Respiratory Distress Syndrome. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:1000-1003

7)

Mariscalco MM Acute Renal Failure. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:1008-1011

8)

Mariscalco MM Multiple Trauma. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, eds. Principles and Practice of Pediatrics, 1st Edition, Philadelphia: JB Lippincott, 1990:1015-1018

9)

Mariscalco MM and Forenberry JD. General Principles of Poisoning. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 2nd Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 1990: 832-836

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 13 of 17

10)

Mariscalco MM Salicylism. In oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 2nd Edition, Philadelphia. JB Lippincott, Williams & Wilkins, 1990: 837-838

11)

Mariscalco MM Acetaminophen Overdose. In oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 2nd Edition, Philadelphia. JB Lippincott, Williams & Wilkins, 1990: 838-804

12)

Mariscalco MM Plant Poisoning. In oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 2nd Edition, Philadelphia. JB Lippincott, Williams & Wilkins, 1990: 840-842

13)

Mariscalco MM. Infection and the Host Response. In: Fuhrman BP, Zimmerman JJ, eds. Pediatric Critical Care, 1st Edition, St. Louis: Mosby-Year Book, Inc., 1992:917-930.

14)

Abbassi O, Mariscalco MM, McEver R., McIntire LV, and Smith CW. Effects of Shear Stress on Leukocyte Adhesion. In: Metcalf BW, Dalton BJ and Poste G, eds. Cellular Adhesion: Molecular Definition to Therapeutic Potential, New York, Plenum Press, 1994:135-151.

15)

Mariscalco MM, Smith CW. Adhesion Molecules and Tissue Injury. In Current Topics in Intensive Care #3, P. Dellinger ed, W.B. Saunders Co Ltd, London 1996:102-130. Mariscalco MM. Infection and the Host Response. In: Fuhrman BP, Zimmerman JJ, eds. Pediatric Critical Care, 2nd Edition, St. Louis: Mosby-Year Book, Inc., 1998:979-994.

16)

17)

Mariscalco MM. Smith CW. Integrins and Cell Adhesion Molecules. In: Polin RA, Fox WW, eds. Fetal and Neonatal Physiology, 2nd Edition, Philadelphia: W. B. Sanders, 1998: 1980-2002.

18)

Mariscalco MM. Shock. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, 1998:2192-2195.

19)

Mariscalco MM. Acute Respiratory Distress Syndrome. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, 1998:2195-2199.

20)

Mariscalco MM. Acute Renal Failure. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, 1998:2201-2204.

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 14 of 17

21)

Mariscalco MM. Multiple Trauma. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, 1998:2211-2214.

22)

Mariscalco MM and Fortenberry JD. General Principles of Poisoning. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 1999:617623

23)

Mariscalco MM. Salicylism. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 1999:623-625 Mariscalco MM. Acetaminophen Overdose. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 1999:625-627

24)

25)

Mariscalco MM. Plant Poisoning In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 3rd Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 1999:628-629

26)

M. Michele Mariscalco Integrins and Cell Adhesion Molecules. In: Fetal and Neonatal Physiology, 3rd Edition; Editors: RA Polin, WW Fox, SH Abman, Elsevier Inc, 2004; Philadelphia PA pp 1572-1590

27)

Mariscalco MM. Salicylism. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 2006, 754-758

28)

Mariscalco MM. Acetaminophen overdose. In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 2006, 759-764

29)

Mariscalco MM. Plant poisoning In Oski FA, DeAngelis CD, Feigin RD, Warshaw JB, McMillan, JA eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, Williams & Wilkins, 2006, 765-767

30)

Mariscalco MM. Shock. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, 2006, 2582-2587

31)

Mariscalco MM. Acute respiratory distress syndrome. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, 2006, 2588-2592

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 15 of 17

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Mariscalco MM. Acute renal failure. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, 2006, 2595-2599

33)

Mariscalco MM. Multiple trauma. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, 2006, 2609-2613

34)

Mariscalco MM, Smith CW. Functional disorders of granulocytes. In: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB, eds. Principles and Practice of Pediatrics, 4th Edition, Philadelphia: JB Lippincott, 2006, 2453-2462

35)

Mariscalco MM. Infection and the host response. In: Fuhrman BP, Zimmerman JJ, eds. Pediatric Critical Care, 3rd Edition, St. Louis: Mosby-Year Book, Inc., 2006, 1299-1319

36)

Typpo K, Mariscalco MM Multiple Organ Dysfunction Syndrome in Pediatric Intensive Care. In Wheeler D, Wong H, Shanley T, eds. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Surrey England Springer-Verlag Inc., 2007,1445-1456.

37)

Mariscalco MM Polymorphonuclear leukocyte. In: Nichols DG, Ackerman AD, Carcillo JA, Dalton HJ, Kisson N, eds. Rogers' Textbook of Pediatric Intensive Care. Fourth Edition.Philadelphia Lippincott and Williams, 2008.

38)

Mariscalco MM. How to Start a Successful Career in Pediatric Critical Care Medicine. Current Concepts in Pediatrics 2009. Society of Critical Care Medicine January 2009

39)

M. Michele Mariscalco Integrins and Cell Adhesion Molecules. In: Fetal and Neonatal Physiology 4th Edition; Editors: RA Polin, WW Fox, SH Abman, Elsevier Inc, 2009; Philadelphia PA In press.

ABSTRACTS: 1)

Timmons OD, Mariscalco MM, Smith CW, Anderson DC, Hansen TN. Effects of lipopolysaccharide and activated neutrophils in experimental lung injury. American Academy of Pediatrics, Critical Care Section, San Francisco, California, October 1988.

2)

Ludomirsky A, Mariscalco MM, Fisher DJ, Smith RT, Garson A, Jefferson LS, McNamara DG. Dysrhythmias during endocarditis and septicemia in children. Cardiology Section, Southern Society for Pediatric Research, February 1986.

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 16 of 17

3)

Timmons OD, Mariscalco MM, Fortenberry JD, Romero L, Hansen TN. Failure of allopurinol and dimethyl sulfoxide to prevent experimental lung injury. American Academy of Pediatrics, Critical Care Section, Chicago, Illinois, October 1989.

4)

Fortenberry JD, Romero L, Timmons OD, Mariscalco MM. Quatification of capillary leak in isolated perfused lungs - Evans blue tissue accrual technique. American Academy of Pediatrics, Critical Care Section, Chicago, Illinois, October 1989.

5)

Mariscalco MM, Shappell SB, Anderson DC, Smith CW. Role of CD18 in adherence dependent hydrogen peroxide production by rabbit neutrophils. FASEB J. 1990;4:494A.

6)

Mariscalco MM, Marolda J, Fortenberry JD, Anderson DC, Smith CW. Effect oflipopolysaccharide on circulating neutrophil CD18 integrins and LAM-1 expression. FASEB J 1991;4:548A. Mariscalco MM, Fortenberry JD, Marolda JA, Bennett RN, Berens KL, Smith CW. Polymorphonuclear Leukocyte Mac-1: Functional epitope for iC3b-binding is distinct from epitopes for adhesion-dependent function. Pediatric Research 1993;4:156A.

7)

8)

Mariscalco MM, ZhaoZheng G, Smith CW. Neonatal Neutrophils (PMNS) are primed for adherence-dependent hydrogen peroxide (H2O2) production. Pediatric Research 1994;35:974A

9)

Sarman G, Mariscalco MM, Hughes BJ, Smith CW. Homotypic aggregation of neonatal neutrophils can be sustained by Kim 185 antibody. Pediatric Research 1995;34:285A

10)

Filipp R, McCord S, Mariscalco MM, Schwarz P. Comparison of two methods for arterial line dressings. United for Children Nursing Conference, Dallas, Texas, 1995.

11)

Graf JM, Rowen JL, Smith CW, Mariscalco MM. Neonatal Lapine Macrophages: A diminished chemoattractant response. Pediatric Critical Care Colloquium, The Cloister, Sea Island, Georgia October 7-11, 1995.

12)

Tcharmtchi MH, Mariscalco MM, Smith CW: P-Selectin (P-SEL) Support of neonatal neutrophil (N-PMN) rolling: Contribution of Neutrophil P-Selectin-Gylocoligand-1 (PSGL-1). Pediatric Research 1997;41:228A.

13)

Vergara WI, Mariscalco MM, Smith CW: Neonatal leukocytes have diminish rolling and adhesion in vivo. Pediatric Research 1998;43:241A.

14)

Landers CD, Smith CW, Mariscalco MM: Contribution of Mac-1 and LFA-1 to neonatal PMN adhesion and migration under shear stress. Pediatric Research 1998;43:239A.

15)

Smith SR, Davis SL, Mariscalco MM, Smith CW, Kaplan SL: The role of ICAM-1 in host response to group A streptococcus. Pediatric Research 1998;43:158A.

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 17 of 17

16)

Landers CD, Smith CW, Mariscalco MM: E-Selectin can support neonatal neutrophil firm arrest under shear stress. American Journal of Respiratory and Critical Care Medicine 1999;159:482A.

17)

Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon JP, Orbinez E, Rowet PC, McLaine PN, Seidman E: Circulating cytokine levels predict the severity of renal failure in classic hemolytic uremic syndrome (HUS). Critical Care medicine 1999;27:A132.

18)

Mariscalco MM, W. Vergara, J. Mei, CW Smith; L-Selectin dependent leukocyte localization is diminished in neonatal rabbits in vivo. FASEB Journal 2000; 14:A287

19)

Mariscalco MM, W. Vergara, J. Mei, C Wayne Smith; Leukocyte adhesion and emigration is depressed in young rabbits in vivo. American Journal of Respiratory and Critical Care Medicine 2000; 161:A846.

20)

Mansour E., Mariscalco MM, C. W. Smith, Neonatal Neutrophil-Platelet adhesion is decreased compared to adult under shear conditions. Pediatric Research 2000; 47:334A

21)

Mariscalco MM, T. Helgason, T-Cells from cord blood have increased adhesion to stimulated endothelial cells compared to adult. Pediatric Critical Care Medicine, 2000;1: S107

22)

Mariscalco MM, Jia Mei, C. Wayne Smith, Ontogeny of Mac-1-Dependent Leukocyte Localization in a Rabbit Model. The FASEB Journal, 2001; 15:A394

23)

Mariscalco MM, Thorunn Helgason, T-Cells from Cord Blood have increased VLA-4Dependent Adhesion compared to Adult on Inflamed Endothelial Cells. The FASEB Journal, 2001; 15:A329

24)

M. Michele Mariscalco, Jia Mei, C. Wayne Smith, Leukocyte Emigration in Four Week Old Rabbits is Equal to Adult Despite Decreased Adhesion. American Journal of Respiratory and Critical Care Medicine, 2001; 163: A987

25)

M. Michele Mariscalco, Emad Mansour, Thortunn Helgason, C. Wayne Smith, Diminished P-Selectin dependent Tether Duration Contributes to Depressed Neonatal Neutrophil-Platelet Interactions. The FASEB Journal (4), 2002; 16:A595

26)

Kennedy CE, Beck JR, Mariscalco MM, Jefferson LS, Smith JW, and Aoki N. “Utilizing Knowledge Discovery to Generate a Model for Mortality from a Pediatric ICU Database.” Poster Presentation Society of Critical Care Medicine, San Diego, CA (January 2002). Critical Care Medicine (2002) Vol. 29, Suppl. 12. 373/S152

27)

Garcia XC, Mariscalco MM, Stayer SA, Fraser C, Jefferson LS: Cardio Pulmonary Bypass Induced Decrease in Exhaled Nitric Oxide is Unassociated with Changes in

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 18 of 17

Pulmonary Mechanics Boston, MA (October 2002). American Academy of Pediatrics 2002, National Conference and Exhibition 28)

Faqih NA, Weisbrodt NW, Mariscalco MM. Delayed Gastric Emptying and decreased gastric acidity in lipopolysaccharide (LPS) treated mice. Crit Care Medicine 2002; 29:A91.

29)

Proulx F, Toledano B., Phan V., Clermont MJ, Mariscalco MM, Seidman EG; Circulating Granulocyte Colony-Stimulating Factor, C-X-C, and C-C Chemokines in Children with Escherichia Coli 0157:H7 Associated Hemolytic Uremic Syndrome. 2002 International Pediatric Research Foundation, Inc., Vol. 52, No. 6, 2002

30)

Mariscalco MM, Helgason T. Cord blood T cells are equally able to migrate on inflamed endothelium as adult cells. FASEB Journal 2004; 18(4); A450

31)

Thammasitboon S., Mariscalco MM, Richards B, Clavier A, Hetland M.D., Noronha P.A., Yudkowsky R, Mrtek R.G. Justifying the Evaluators for a 360° Competency Assessment: Four Distinct Expectations of an Ideal Pediatric Resident. FASEB Journal 2004; 18(4); A450

32)

Decaluwe H, Proulx F, Mariscalco MM, Gendrel D, Bohuon C. Procalcitonin in children with Escherichia Coli 0157:H7 hemerrhagic colitis and hemolytic uremic syndrome. Presented at 12th International Congress fo Immunology and 4th Annual conference of FOCIS. Clin Invest Med J 2004, 27 (4): 125B.

33)

Mariscalco MM, Helgason T., TNF but not IFNγ stimulation of EC results in increased neonatal T cell motility under shear conditions. FASEB Journal 2005; 19(4); A928

34)

Desai M, Mariscalco MM, Smith CW. Nutritional hypercholesterolemia increases hepatic inflammatory response to acute endotoxemia.” Experimental Biology April 5, 2006, San Francisco, Late-Breaking Abstract #534.

35)

Moreshwar S. Desai, M. Michele Mariscalco Role of toll Receptor 4 (TLR4) in the Hepatic Inflammatory Response to Atherogenic Diet in a Rodent Model of Nutritional hypercholesterolemia, Crit Care med Vol. 34, No. 12 (Suppl)

36)

Germain, A.M., Helgason, T., Smith, C.W., Mariscalco, M.M, Effect of Transendothelial Migration on Neonatal and Adult Neutrophil Integrin Expression, Pediatric Academic Society May 5, 2007, E-PAS 2007: 61: 5745.11

37)

Typpo, K., Petersen, N., Hallman, D.M., Markovitz, B., Mariscalco, M.M., Impact of Premorbid Conditions on Multiple Organ Dysfunction Syndrome in the PICU, Pediatric Academic Society, May 5, 2007, E-PAS 2007: 61: 8418.2

CURRICULUM VITAE Mary Michele Mariscalco, M.D. Page 19 of 17

38)

Typpo K, Mariscalco MM, Petersen NJ, Hallman DM, Markovitz B. Outcomes of Multiple Organ Dysfunction Syndrome in the Pediatric ICU. Crit Care Med 2007; 35(12): A12.

39)

Velasquez P, Mariscalco MM, MD, Goldstein SL, Airewele G. Outcomes After Erythrocytapheresis For Children With Acute Chest Syndrome. American Society for Apheresis. Galveston Texas, April 2008.

40)

Typpo K, Petersen NJ, Hallman DM, Markovitz B, Mariscalco MM. Impact of Admission Organ Dysfunction on Functional Outcomes in the Pediatric Intensive Care Unit. Am J Respir Crit Care Med 2008; 177:A983.

41)

Typpo K, Mariscalco MM, Peterson N, Petersen L. Chronic Illnesses are Not Associated with Functional Outcome in the PICU. Crit Care Med 2008; 36(12) A81.

42)

Ung B, Lai YC, Wilfong A, Mariscalco MM Sudden onset malignant epilepsy (SOME) Syndrome constitutes a subset of encephalitis with IgM+ Mycoplasma Pneumoniae. EPAS20102714.150