DOES UNILATERAL LOBECTOMY SUFFICE TO MANAGE UNILATERAL NON-TOXIC GOITER?

Short title: Unilateral lobectomy in thyroid disease

Authors Gurkan Yetkin, MD;1 Mehmet Uludag, MD;1 Ozgun Onceken, MD;1 Bulent Citgez, MD;1 Adnan Isgor, MD;2 Ismail Akgun, MD1

Authors’ institution 1. Sisli Etfal Research and Training Hospital, 2nd Department of General Surgery, Istanbul, Turkey 2. Halic University, Department of General Surgery, Istanbul, Turkey

Address for correspondence: Dr. Gurkan Yetkin Address: Atakoy 3. kisim O8 Blok Daire:7 Bakirkoy Istanbul, TURKEY Tel: +90 532 6139471 Fax: +90 216 4188751 e-mail: [email protected] DOI: 10.4158/EP09140.OR 1

ABSTRACT:

Objective: In unilateral benign non-toxic goiter, resection may involve either unilateral or total thyroidectomy, each having its own advantages and disadvantages. This study aimed to evaluate the results of ipsilateral lobectomy in unilateral non-toxic benign nodular goiter and to define predictive factors for recurrence. Methods: A total of 104 patients undergoing thyroid lobectomy for unilateral non-toxic benign nodular goiter between 2002 and 2007 were included. Potential predictors of recurrence including age, gender, family history, pre-operative size of the thyroid gland, number, size, and ultrasound characteristics of the preoperative nodules, duration of postoperative follow-up, postoperative use of thyroxine, and histopathological diagnoses were recorded at baseline and patients were followed for the development of recurrence. Results: Patients were operated for adenoma (n=45), colloidal nodular goiter (n=45), or thyroiditis (n=14). Average duration of follow-up was 39.75±21.75 months (range: 5-87). Recurrence was seen in 63 (60.57%) patients. Based on multivariate analysis, histopathology of the lobectomy material (p