Multifunctional Additives Dermosoft® SLL

Multifunctional Additives

Product Information

dermosoft ® decalact Product features

Antimicrobial active substance Effective against microorganisms causing skin disorders such as: ● dandruff ● skin odor ● athlet‘s foot 100 % natural alternative to triclosan and climbazol ECOCERT registered

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Multifunctional Additives dermosoft® decalact

dermosoft® products cover many cosmetic functions

dermosoft®decalact features natural antimicrobial activity against:

● Melassezia Furfur (Dandruff)

The product line dermosoft® products are carefully chosen multifunctional cosmetic ingredients. The well balanced product profiles are tailored to the needs of cosmetic formulations. Basic cosmetic functions like hydrating, conditioning, masking and others are combined with an excellent antimicrobial profile. dermosoft® products will meet many of your requirements for the improvement of cosmetic formulations and along the way protect the product against microorganisms. With the aid of dermosoft® cosmetic products can easily be formulated without traditional preservatives.

dermosoft® decalact The product’s active principle is based on a mixture of middle chain acyl lactylate produced from 100 % natural components. The antimicrobial efficacy of dermosoft® decalact is optimized to act specifically against microorganisms causing skin disorders like dandruff or athlet‘s foot or to avoid conditions like skin odor.

● Dermatophytes (Athlete’s foot) ● Candida albicans (intimate hygiene) ● Propionibacterium acnes (Acne) ● Corynebacterium xerosis (Deo)

The anionic character of the product supports its adhesion to the skin and provides a long term efficacy. With that efficacy profile dermosoft® decalact is the perfect naturally derived alternative to Piroctone Olamine and Zinc Pyrithion in anti-dandruff shampoos or to Triclosan and Climbazole in products against athlet‘s foot. For specific test results please refer to the related sections below.

Application dermosoft® decalact is a transparent highly viscous liquid. In rinse-off products it is recommended to incorporate dermosoft® decalact into the concentrated surfactants. In O/W-emulsions the incorporation into the water or oil phase is possible. The viscosity of dermosoft® decalact can be reduced by dilution with glycerin or the parfum. The dosage of dermosoft® decalact is depending on the desired effect. Typical dosages are between 0,5 and 2,0%. When used at higher concentrations dermosoft® decalact may affect the emulsion stability. dermosoft® decalact may influece the performance of some polymeric gelling agents. As frequently observed for anionic surface active ingredients the pH of the final formulation with dermosoft® decalact may shift to lower values. In aqueous or alcoholic solutions the use of a solubilizer may be necessary.

Characteristics of dermosoft® decalact Appearance

Amber, highly viscous liquid

Chemical Name

Sodium Decanoyl/Dodecanoyl Lactylate

INCI

Sodium Caproyl/Lauroyl Lactyl Lactate

Recommended dosage

0,5 – 2,0 %

pH-range

4,0 - 7,5

Regulatory status CMR-ingredients

Registered in EU, Japan No

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Multifunctional Additives dermosoft® decalact

Activity as antimicrobial active substance The activity against specific microorganisms related to skin conditions has been evaluated in-vitro and in-vivo.

dermosoft®decalact activity against various microorganisms

dermosoft® decalact against Candida albicans The specific activity of dermosoft® decalact against Candida albicans has been checked in in-vitro in a rinse-off surfactant base and a carbopol gel. The activity against Candida is relevant for feminine intimate hygiene products. rinse-off base pH 4,5 10000000

plate count [cfu/ml]

1000000 100000 10000 1000

dermosoft® decalact 2,0% 100

Climbazole 0,4% Placebo

10 1 0

2

4

6

8

p

10

12

hours

14

c

16

d

18

20

22

24

Carbopol gel pH 4,2

10000000

plate count [cfu/ml]

1000000 100000 10000 1000

dermosoft® decalact 1,0%

100

Placebo

10 1 0

2

4

6

8

10

hours

12

14

p

16

18

d

20

22

24

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Multifunctional Additives dermosoft® decalact

dermosoft® decalact against Trichophyton mentagrophytes, Trichophyton rubrum und Epidermophyton floccosum dermosoft®decalact activity against athletes foot and nail fungus

These three microorganisms belong to the group of dermatophytes feeding on carbohydrate and keratin.

Pemulen gel pH 5,5

1000000

plate count [cfu/ml]

100000 10000 1000 100 10 1

R6

R5

00

02

R4

04

06

R3

08

10

12

hours

Epidermophyton floccosum

Trichophyton rubrum

R2

14

16

R1

18

20

22

24

Trichophyton mentagrophytes

dermosoft® decalact 1,0%

dermosoft® decalact 1,0%

dermosoft® decalact 1,0%

Placebo

Placebo

Placebo

aqueous solution with 2% Polysorbate-20 pH 5,0 1000000

plate count [cfu/ml]

100000 10000

Trichophyton rubrum 1000

dermosoft® decalact 1,0% 100

Placebo

10 1 00

02

04

06

08

10 hours

12

R2

14

16

R1

18

20

22

24

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Multifunctional Additives dermosoft® decalact

dermosoft®decalact activity against athletes foot and nail fungus

OW-emulsion foot cream

Trichophyton mentagrophytes dermosoft® decalact 0,5%

1000000

Triclosan 0,3% plate count [cfu/ml]

100000

Climbazole 0,4% Placebo

10000 1000 100 10 1 00

04

08

12

pl3

16

clim

20

24

28

hours

tric

32

d0,6

36

40

44

48

OW-emulsion well fit foot cream pH 5,3

Trichophyton mentagrophytes dermosoft® decalact 1,0% dermosoft® decalact 0,5% Triclosan 0,3%

1000000

Climbazole 0,4% plate count count [cfu/ml] [cfu/ml]

100000

Placebo

10000 1000 100 10 1

0

16

0

32

8

pl3 R5 clim R4

48

16

64

24 hours

32

80

40

tric R3 d0,6 R2

96

48

112

56

d1,0 R1

128

64

144

72

The composition of the foot cream is displayed on the next page

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Multifunctional Additives dermosoft® decalact ….against athlet‘s foot

Well Fit Foot Cream 110-20-1010

Claims:

Moisturizing and rich cream for feet with rough and chapped skin Prevention of athlete’s foot and unpleasant odor dermosoft® decalact as proven active

Phase

Ingredient

INCI

A

Deionised Water

Aqua

Supplier

% 50.55

Glycerol (85%)

Glycerin

Merck

2.00

dermofeel® PA-3

Sodium Phytate, Aqua

Dr. Straetmans

0.10

dermosoft® OMP

Methylpropanediol; Caprylyl Glycol; Phenylpropanol

Dr. Straetmans

4.00

A1

Keltrol CG-SFT

Xanthan Gum

CP Kelco

0.50

LaraCare A 200

Galactoarabinan

Larex

0.25

B

dermofeel® GSC

Glyceryl Stearate Citrate

Dr. Straetmans

3.00

dermosoft® decalact

Sodium Caproyl/Lauroyl Lactyl Lactate

Dr. Straetmans

1.00

Stearinsäure D2

Stearic Acid

Gustav Hees

5.00

Cutina GMS V

Glyceryl Stearate

Cognis

2.00

dermofeel® BGC

Butylene Glycol Dicaprylate/Dicaprate

Dr. Straetmans

7.00

Cupuacu Butter Refined

Theobroma Grandiflorum Seed Butter, Tocopherol

Beraca*

5.00

Cremerlin Pura

Olus (Vegetable) Oil

Cremer Care

7.00

Tricaprylin

Dr. Straetmans

2.00

dermofeel TEC eco

Triethyl Citrate

Dr. Straetmans

3.00

dermofeel® Toco 70

Tocopherol, Helianthus Annuus (Sunflower) Seed Oil

Dr. Straetmans

0.05

Frescolat ML cryst.

Menthyl Lactate

Symrise

0.20

®

dermofeel MCT ®

B1 C D

Deionised Water

Aqua

Emprove Harnstoff perlform

Urea

Merck

5.00 2.00

Perf. Grapefruit

Parfum

Cosnaderm

0.35 100.00

Manufacturing Procedure: 1. Heat phase A and B up to 78°C. Disperse A1 in A and dissolve B1 in phase prior emulsification. 2. Emulsifiy phase A into phase B Homogenize for approx. 2 min. using an Ultra-Turrax 3. Cool down to 35°C under stirring and add pre-solution of phase C and perfume oil.

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Multifunctional Additives dermosoft® decalact

dermosoft® decalact against Malassezia furfur dermosoft®decalact activity against dandruff

in-vitro tests with dermosoft®decalact

The yeast Malassezia furfur (old name: Pityrosporum ovale) is known to be a main influencing factor in the formation of dandruff. Therefore all dandruff actives are targeting to eliminate Malessezia furfur on the scalp. As most cosmetic antidandruff products are rinse-off concepts an appropriate active has to exhibit both rapid kill and substantivity to the skin. dermosoft® decalact is perfectly fulfilling these requirements as has been demonstrated in in-vitro and in-vivo studies. A) aqueous solution with 2,5% Polyglyceryl-10 Laurate pH 5,3 B) Shampoo formulation pH 5,3

dermosoft® decalact 2,0%

Piroctone Olamine 0,75% Placebo 1000000

plate count [cfu/ml]

100000 10000 1000 100 10 1

p c

0 10

d

20

R3

30 minutes

R2

40

R1

50 60

It becomes evident that the in-vitro performance in the presence of surface active ingredients in the shampoo is considerable slower than in water with Polyglyceryl-10 Laurate as solubilizer. Further in-vitro tests with different time scale allow to compare the performance of dermosoft® decalact with Piroctone Olamine. A) Shampoo formulation pH 4,3 B) Shampoo formulation pH 5,3

dermosoft® decalact 2,0% Piroctone Olamine 0,75% Placebo

1000000

plate count [cfu/ml]

100000 10000 1000 100 10 R13 R11

1 0

R9

60

R7

120

R5

180 minutes

R3

240

R1

300 360

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Multifunctional Additives dermosoft® decalact

dermosoft®decalact activity against dandruff

in-vivo test with dermosoft®decalact

In order to evaluate the practical relevance of the initial in-vitro findings an in-vivo study with 60 volunteers has been performed. The panel has been divided into three groups of 20 individuals. The shampoo with 2% dermosoft® decalact, 0,75% Piroctone Olamine and no active as control has been tested. Details of the study design are available upon request. The shampoo formulation is displayed on the next page. It is the same formulation marked as “B” in the in-vitro tests.

0,00%

- 6%

-5,00%

Reduction of dandruff scales by weight

-10,00%

- 25%

- 24%

-15,00% -20,00% -25,00% -30,00% Placebo

2,0 % dermosoft decalact

0,75 % Octopirox

5,00%

+4 %

Reduction of total surface of corneocytes adhering on a D-squame

0,00%

- 6% -11 %

-5,00%

-10,00%

-15,00% Placebo

0,00%

Number of corneocytes > 0,5 mm² adhering on a D-squame

2,0 % dermosoft decalact

0,75 % Octopirox

-2%

-10,00%

-20,00%

-40%

-36%

-30,00%

-40,00%

-50,00% Placebo

2,0 % dermosoft decalact

0,75 % Octopirox

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Multifunctional Additives dermosoft® decalact ….against dandruff (in-vitro)

Shampoo Med Anti-Dandruff D033-2.2-710

Claims*:

Phase A

A1

B

anti dandruff efficacy supported by dermosoft® decalact Optimum conditioning for all hair types

Ingredient

INCI

Supplier

%

Deionised Water

Aqua

dermofeel® PA-3

Sodium Phytate, Aqua

Dr. Straetmans

54.10 0.10

dermosoft® 1388

Glycerin, Aqua, Sodium Levulinate, Sodium Anisate

Dr. Straetmans

3.50

D-Panthenol

Panthenol

BASF

1.00

Texapon N 70

Sodium Laureth Sulfate

Cognis

14.00

Tego Betain F 50

Cocamidopropyl Betaine

Evonik Goldschmidt

8.00

Rewopol SB FA 30 ph

Disodium Laureth Sulfosuccinate

Evonik Goldschmidt

5.00

dermosoft® decalact

Sodium Caproyl/Lauroyl Lactyl Lactate

Dr. Straetmans

2.00

Deionised Water

Aqua

Amylomer™ H 75 M

Hydroxypropyl Oxidized Starch PG-Trimonium Chloride

Dr. Straetmans

2.00

Perf. Atemoxa Shower Gel Frag 489881

Parfum

Drom

0.30

Sodium Chloride

Sodium Chloride

Citric Acid (sol.20%)

Citric Acid

10.00

q. s. Merck

q. s. 100.00

Manufacturing Procedure: 1. Mix ingredients of phase A in given order until completely dissolved. 2. Add premix of A1. 3. Add Components of phase B and adjust viscosity with sodium chloride and pH with citric acid. Specification Values: Appearance: clear viscous gel. pH: 5.2 – 5.4. Viscosity (Brookfield: LV 3; Speed 10): 3.000 – 6.000 mPa.s. Stability: Stable for more than 3 months at 40°C, room temperature, and 4°C Microbiological stability: Proven. * anti-dandruff claim supported by in vivo and in vitro efficacy studies

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Multifunctional Additives dermosoft® decalact

dermosoft® decalact against Propionibacterium acnes dermosoft®decalact activity against acne

Acne is a local inflammation on the skin. In the first step an excess sebum production is plugging skin pores. The warm and moist conditions in the closed pores are perfect to promote the growth of anaerobic microorganisms such as Propionibacterium acnes. The growing population of microorganisms is stimulating an inflammation reaction that leads to visible red pimples. Consequently an acne treatment concept is aiming to -control the sebum excretion -fight the microorganisms -stop the inflammation dermosoft® decalact can be used to fight the relevant microorganisms in such a acne treatment concept. The performance against Propionibacterium acnes has been demonstrated in an in-vitro study:

aqueous solution with 1% Polyglyceryl-10 Laurate pH 4,5

1000000

Propionibacterium acnes

plate count [cfu/ml]

100000

dermosoft® decalact 1,0%

10000

dermosoft® decalact 0,5% Triclosan 0,3%

1000

Salicylic acid 0,5% 100

Placebo

10 1 0

60 120

plac

180 minutes

tric

240

d1%

300 360

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Multifunctional Additives dermosoft® decalact

dermosoft® decalact against Corynebacterium xerosis Deodorant formulations are based on three pillars:

dermosoft®decalact activity against body odor

-prevention of sweat formation -prevention of odor formation -masking of odor The role of dermosoft® decalact in concepts against body odor is to control those microorganisms being responsible for the degredation of sweat into odorous compounds. The performance against Corynebacterium xerosis has been demonstrated in an in-vitro study:

aqueous solution with 1% Polyglyceryl-10 Laurate pH 5,0

1000000

dermosoft® decalact 0,3%

plate count [cfu/ml]

100000

Placebo

10000 1000 100 10 1 0 60 120

R5

180 minutes

R3

240

PO

300 360

For more information regarding the activity against body odor please refer to the product leaflet of dermosoft® decalact deo. dermosoft® decalact deo is a specific blend for deodorant applications. The superior performance is proven by an in-vivo sniff test study against benchmark.

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Multifunctional Additives dermosoft® decalact

Dozens of formulation examples are compiled in our Formulary

Formulations with our products are available for both, traditional and natural cosmetics concepts. Please refer to the Dr. Straetmans homepage for formulation inspirations. Toxicology dermosoft® decalact is not sensitizing and does not contain genetically modified

material, dioxine, phthalates, BSE-related material or CMR-material. It has been evaluated as a safe cosmetic and food ingredient with an excellent toxicological profile1,2,3. Packing units dermosoft® decalact is available in 16 kg net metal cans.

Environmental Information dermosoft® decalact is produced in an environmentally unobjectionable process by esterification of pure natural components. dermosoft® decalact is readily biodegradable. dermosoft® decalact has not been tested on animals. Handling and storage In closed original containers dermosoft® decalact can be stored for at least 3 years. dermosoft® decalact does not need to be preserved and thus does not contain any preserving agents. Literature 1 L.J. Murphy, F. Baiocchi, Acyl Lactylates in Cosmetics, Drug and Cosmetic Industry, 1978, 35-46. 2 L.I. Osipow, D. Marra, N. Resnansky, Fatty Acid Lactylates, Drug and Cosmetic Industry, 1969, 3, 4, 5. 3 WHO Food Additives Series No. 5, 1974

For further information contact our Dr. Straetmans sales team: [email protected] or your local representative.

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Multifunctional Additives dermosoft® decalact

Our representatives abroad

Europe

Romania Korea Biesterfeld Spezialchemie Romania S.R.L. HANA Trading Company E-Mail: [email protected] E-Mail: [email protected] Benelux www.biesterfeld-spezialchemie.ro Jan van Laarhoven-Waalwijk b.v. Malaysia E-Mail: [email protected] Spain Ingredients Plus Sdn Bhd Comercial Quimica Jover, S.L. E-Mail: [email protected] Bulgaria E-Mail: [email protected] Biesterfeld Pro Specialty Chemicals Phillippines E-Mail: [email protected] www.cqjover.com CTC Far East Phils. Inc. www.biesterfeldpro.com Sweden/Finland E-Mail: [email protected] Bionord AB www.ctc-group.com Croatia E-Mail: [email protected] Biesterfeld Spezialchemie d.o.o. www.bionord.se Thailand E-Mail: [email protected] Adinop Co. Ltd. www.biesterfeld.hr Switzerland E-Mail: [email protected] Rahn AG www.adinop.co.th Czech Republic E-Mail: [email protected] Biesterfeld Silcom s.r.o. www.rahn-group.com E-Mail: [email protected] Americas www.bisi.cz Turkey Argentina Kalekimya Denmark/Iceland/Norway nordest nova s.a. E-Mail: [email protected] E-Mail: [email protected] Bionord A/S www.kalekimya.com E-Mail: [email protected] www.nordest-nova.com www.bionord.dk Asia/Pacific Brasil France Beraca Sabará Quimicos e Ingredientes S.A. Lucas Meyer Cosmetics S.A. E-Mail: [email protected] Australia / New Zealand E-Mail: [email protected] www.beraca.com RejuvaCare www.lucasmeyercosmetics.com E-Mail: [email protected] Chile www.rejuvacare.com.au Great Britain Maprin Representaciones Ltda. Gemro Products Ltd. E-mail: [email protected] China E-Mail: [email protected] www.maprin.cl Shanghai Hope Tec www.gemroproducts.com E-Mail: [email protected] Colombia www.htchem.com.cn Greece Cromaroma Ltda. Cellco Chemicals Ltd. E-mail: [email protected] India E-Mail: [email protected] N.V. Organics PVT. LTD. www.cellco.gr Mexico E-Mail: [email protected] Noregal S.A. de C.V www.nvorganics.com Hungary E-Mail: [email protected] Biesterfeld Special Chemicals Hungary Ltd. Iran E-Mail: [email protected] USA Tooska-E-Khorasan Trading Co. www.biesterfeld.hu Kinetik Technologies, Inc. E-Mail: [email protected] E-Mail: [email protected] www.tooskaco.com Italy www.kinetiktech.com Pharma Cosm Polli srl Israel E-Mail: [email protected] Africa Tagra Biotechnologies www.pharmacosm.it E-Mail: [email protected] www.efal.com South Africa Poland Meganede Biesterfeld Polska Sp.z.o.o. Japan E-Mail: [email protected] E-Mail: [email protected] GSI Creos Corporation www.meganede.com www.chemia.biesterfeld.com.pl E-Mail: [email protected]

DS decalact / 2012-4

Russia Chemical Service Ltd. E-Mail: [email protected] www.chemical-service.com

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