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(19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0235065 A1 Hansen et al.
(43) Pub. Date:
(54) ALPHA-FETOPROTEIN IMMU31
NOV. 25, 2004
Related US. Application Data
ANTIBODIES AND FUSION PROTEINS AND METHODS OF USE THEREOF
(60)
Provisional application No. 60/399,707, ?led on Aug. 1, 2002.
(75) Inventors: Hans J. Hansen, Picayune, MS (US); ZhengXing Qu, Warren, NJ (Us);
Publication Classi?cation
David M. Goldenberg, Mendham, NJ (Us)
(51)
Int. Cl.7 ...................... .. G01N 33/567; C07K 16/18
(52)
US. Cl. ...................................... .. 435/721; 530/388.1
Correspondence Address: Heller Ehrman & McAuli?'e
(57)
ABSTRACT
1666 K Street Northwest, Suite 300
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Washington, DC 20006 (Us)
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The present invention provides humanized, chimeric and
human anti-alpha-fetoprotem antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and
(73) Assignee; Immunomedics, Inc_
fragments thereof, as Well as combinations With other suit
(21) Appl, N()_j
10/631,722
(22) Filed:
Aug. 1, 2003
able antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other APP-producing tumors.
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