Microbiology, Immunology, and Cancer Biology Retreat
Zehmer H all
Goal: To highlight and celebrate the breadth and depth of research within MIC and to foster interactions and collaborations between the diverse laboratories in our department.
5/15/2015
Microbiology, Immunology, and Cancer Biology 2015 Retreat
Schedule of Events 8:00 8:45 9:00 10:30 10:45 12:00 1:00 2:15 2:30 3:15 4:00 5:00
Continental Breakfast
Servery
Welcome
Auditorium
Research Talks
Auditorium
Coffee Break
Lobby
Research Talks
Auditorium
Lunch
Auditorium
Research Talks
Auditorium
Coffee Break
Lobby
Poster Session 1 (Odd)
Auditorium
Poster Session 2 (Even)
Auditorium
Fun Activity & Reception
Auditorium
Closing & Awards
Auditorium
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Microbiology, Immunology, and Cancer Biology 2015 Retreat
Map of Zehmer Hall:
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Microbiology, Immunology, and Cancer Biology 2015 Retreat
9:00-‐10:30
Kwon Park Erin Saks (Slack-‐Davis Lab) Tim Bender CJ Anderson (Kendall Lab)
10:00-‐10:15 10:45-‐12:00
Aldo Nascimento (Kashatus Lab) Dan Gioeli Sanja Arandjelovic (Ravichandran Lab) Richard Juneau (Criss Lab)
12:00-‐1:00 1:00-‐2:15
Amy Bouton Kelly Cox (Erickson Lab) Marie-‐Louise Hammarskjold
Research Talks: Session 1
"Streamlined Approaches to Determine Lung Cancer Drivers" Short Talk: “Alkyl-‐lysophosphatidic acid: a potent inhibitor of ovarian cancer cell growth.” “Title: TBA” Short Talk: “Ethanolamine Is a Signal That Promotes Salmonella enterica serovar Typhimurium Virulence.”
Coffee Break
Research Talks: Session 2
Lobby Chair: Awndre Gamache
Short Talk: “Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-‐Driven Tumor Growth.” “Title: TBA” Short Talk: “Engulfment protein ELMO1 is a novel regulator of Rheumatoid Arthritis.” Short Talk: “A Thermonuclease of N. gonorrhoeae Enhances Bacterial Escape from Killing by NETs”
Lunch
Lobby/Auditorium
Research Talks: Session 3
Chair: Stephanie Ragland
“Control of Intestinal Epithelial Maintenance and Repair by Focal Adhesion Kinase (FAK) and its close relative, Pyk2.” Short Talk: “Identifying novel B cell subsets that play a role in red meat allergy through the use of mass cytometry” "Of Viruses and Fish"
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Chair: Sowmya Narayanan
Microbiology, Immunology, and Cancer Biology 2015 Retreat
2:30
Poster Session
Auditorium
Poster 1
2:30 – 3:15 Odd Numbers 3:15 – 4:00 Even Numbers Presenter Sanja Arandjelovic
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Louise Ball
3
Allison Batties
4
Alexandra Bettina
5
Emily A. Billings
6
Napoleon Butler
7
Amber Cardani
8
Carrie Cowardin
9
Andrea Daamen
10
Jeff Donowitz
11
Aaron Fond
12
Awndre Gamache
13
Allissia A. Gilmartin
14
Phillippe Gonzalez
15
Margaret Grant
16
Laurie Gray
17
Adam Greene
18
Krystal Haley
19
Jessica Harakal
20
Casandra Hoffman
Authors Sanja Arandjelovic, Scott F. Walk, and Kodi S. Ravichandran Louise Ball and Alison Criss Allison Batties, Yucheng Gao, Keena Thomas, and Amy Bouton Alexandra Bettina, Zhimin Zhang, Kathryn Michels, Marie Burdick, Borna Mehrad Emily A. Billings, Soumita Das, Chang Sup Lee, Kodi S. Ravichandran, and James E. Casanova Napoleon Butler, Dong-‐Wook Kim, Kwon Park Amber Cardani and Thomas Braciale Carrie Cowardin, Sarah Kuehne, Carsten Schwan, Erica Buonomo, Klaus Aktories, Nigel Minton, and William Petri, Jr. Shawn Fahl, Andrea Daamen, Rowena Crittenden, and Timothy Bender Donowitz JR, Haque R, Kirkpatrick BD, Colgate R, Alam M, Ma J, Lu M, Petri WA Aaron M. Fond, Chang Sup Lee, Ira G. Schulman, Robert S. Kiss, and Kodi S. Ravichandran Awndre Gamache, Alyssa Gillespie, Billy Nash and Michael Brown Allissia A. Gilmartin, Katherine S. Ralston, and William A. Petri, Jr. Phillippe Gonzalez and Hui Zong
Margaret J. Grant, Thomas J. Ellison, Dean H. Kedes, and M. Mitchell Smith Laurie Gray, Patrick Jackson, Emily Sloan, Chringma Sherpa, Stuart LeGrice, Marie-‐ Louise Hammarskjold and David Rekosh Adam Greene and Jim Casanova Krystal M. Haley, Monika Sharma, James G. Robertson, Brandt Levitt, Mariano A. Garcia-‐Blanco, and Daniel A. Engel Jessica Harakal, Claudia Rival, Hui Qiao, and Kenneth Tung Casandra Hoffman, M. Gray, Y. Reyes, J. Eby, R. Osicka, L. Bumba, P. Sebo, J.
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Title Engulfment protein ELMO1 is a novel regulator of Rheumatoid Arthritis Controlling the Expression of Phase Variable Proteins in Neisseria gonorrhoeae BCAR3 in Mammary Gland Development and Breast Cancer The role of mononuclear phagocytes in host defense against Klebsiella pneumonia: an essential role of M-‐ CSF BAI1 regulates macrophage ROS driven bactericidal activity against Gram negative bacteria Characterization of Bcat1 as a Novel Therapeutic Target for SCLC Alveolar macrophages regulate alveolar epithelial cells to influenza A infection Binary toxin increases mortality due to Clostridium difficile via pathogenic inflammation c-‐Myb regulates survival and IL-‐7R signaling in pro-‐B cells Examination of Small Intestine Bacterial Overgrowth in Bangladeshi Two Year Olds Apoptotic cells trigger a new pathway in macrophages to increase ABCA1 expression Interrogating the role of paired activating/inhibitory receptors on NK cell responsiveness to MCMV The Role of Lysosomes and Amoebapores in Amoebic Trogocytosis and Cell Killing Deciphering individual roles of p53 and NF1 in the cell of origin for malignant glioma and the implications of targeted therapy. Modeling of the KSHV episome-‐host chromatin synapse by super-‐resolution microscopy Detailed Analysis Of Rev And RRE Evolution During Human Infection Manipulation of host cell signaling by the Salmonella effector SipC Identifying and characterizing inhibitors of dengue host factors Loss of Regulatory T Cells Leads to Th2-‐Dominant Murine Autoimmune Gastritis Novel Regulatory Role for Bacterial Toxin: Adenylate Cyclase Inhibits Bordetella biofilm
Microbiology, Immunology, and Cancer Biology 2015 Retreat Melvin, P. Cotter, E. Hewlett Nicholas E. Sherman, Erin D. Jeffery, John D. Shannon M. Brittany Johnson, Richard A. Juneau, and Alison K. Criss Jungeun Kim, Phillippe Gonzalez, Alyssa Kelder and Hui Zong Peter Krueger, Sowmya Narayanan, and Young Hahn Ewa Kubicka, David L. Brautigan Agata Lemiesz, Tiffany A. Melhuish, David Wotton, Lucy F. Pemberton Ryan A. Llewellyn and Amy H. Bouton
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Erin Jeffery
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M. Brittany Johnson
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Jungeun Kim
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Peter Krueger
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Ewa Kubicka Agata Lemiesz
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Ryan A. Llewellyn
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Nontokozo D. Matume Nontokozo D. Matume, Laurie R. Gray, Patrick E. H. Jackson, Denis M. Tebit, David Rekosh, Marie-‐Louise Hammarskjöld Elizabeth S. McKenney Elizabeth S. McKenney and Melissa M. Kendall Chris Medina Chris Medina, Chang-‐Sup Lee, Yu-‐hsin Chiu, Doug Bayliss, Kodi Ravichandran Emily Mercadante Emily Mercadante, Tessy Iype, Mohan Sankarshanan, and Ulrike Lorenz Kathryn Michels Kathryn Michels, Alexandra Bettina, Zhimin Zhang, Marie Burdick, and Borna Mehrad Tsuyoshi Miyake Tsuyoshi Miyake, Krystal M. Haley, James G. Robertson, Daniel A. Engel Brett Moreau G. Brett Moreau, Sarah Koch, Adam Scheletter, and Barbara Mann Lyndsey Muehling L. Muehling, C. Wogsland, R. Agrawal, P. Heymann, J. Irish, J. Woodfolk Sowmya Narayanan Sowmya Narayanan, Albert Nieh, Kyle Hoehn, Brandon Kenwood, Annie Tosello-‐Trampont, Stephen Caldwell and Young S. Hahn Aldo Nascimento Aldo Nascimento Jennifer A. Kashatus, Lindsey J. Myers, Annie Sher, Frances L. Byrne, Kyle L. Hoehn, Christopher M. Counter, and David F. Kashatus William T. Nash William T. Nash and Michael G. Brown
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Zannatun Noor
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Carleigh O’Brien
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Kunj B. Pathak
Kunj B Pathak, Jonathan Bethke, James Robertson, Monika Sharma, Mario Geysen, Daniel A Engel
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Kristen Penberthy
Kristen Penberthy, Kodi S Ravichandran
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Zannatun Noor, Stacey Burgess, Carrie Cowardin, Erica L. Buonomo, Caitlin Naylor, and William A. Petri, Jr. Carleigh O’Brien and Tajie Harris
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UVA Mass Spectrometry Core Services Identifying gonococcal components that stimulate neutrophil extracellular trap release Developing anti-‐competition treatment method for glioblastoma therapy + + Liver-‐resident NKG2A CD49a ILC1 mediate anti-‐viral + CD103 DC activation Profiling pTyr Signaling in Human Immune Cells Developing a model to analyze epigenetic changes during cancer progression. Pyk2 Regulates Myelopoiesis During Acute Inflammatory Conditions Analysis Of Patential Co-‐Evolution Of Host Cell Editing Enzymes And Hiv-‐1 In South African Populations
A small protein controls virulence gene expression in enterohemorrhagic E. coli O157:H7 Caspase-‐mediated activation of pannexin channels SHP-‐1 regulates conventional T cell resistance to suppression by regulatory T cells Type I interferon signaling promotes defense against Klebsiella pneumoniae pneumonia Yeast-‐based approach to discovery of small molecule inhibitors of Ebola virus Francisella tularensis is resistant to changes in host intracellular zinc concentration Use of Mass Cytometry to Identify T Cell Populations Involved in Pathogenic Responses to HRV Distinct roles for de novo synthesized and exogenous lipids in hepatitis C
Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-‐Driven Tumor Growth
Type I interferon-‐independent inflammation drives the loss of key dendritic cell populations IL-‐25 Mediated Protection From Amoebic Colitis
A suppressive role for ICOS in the CNS during T. gondii infection In Cell Western Based High Throughput Screening Of A Three-‐Point Diverse Scaffold Collection Of 20020 Small Molecules Reveals Compounds Broadly-‐Active Against Dengue Virus in Mammalian and Mosquito Cells Genetic and Pharmacological Approaches to Promote Apoptotic Cell Clearance In Vivo
Microbiology, Immunology, and Cancer Biology 2015 Retreat 43
Sarah Pollock
Sarah Pollock and David Kashatus
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Stephanie Ragland
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Timothy A. Raines
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James G. Robertson
Stephanie Ragland, Kathleen Hackett, Joseph Dillard, and Alison Criss Timothy A. Raines, Kevin R. Lynch, and Jill K. Slack-‐Davis James G. Robertson, Jonathan Bethke, Joseph Jablonski, Andrew Cheetham, Ku-‐ Lung Hsu, Charles Grisham, Daniel Engel
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Tiffany Shand
Tiffany Shand, Ying Jiang, Maojin Yao, and Hui Zong
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Asya Smirnov
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Jacqueline S. Stevens
Asya Smirnov, Kylene P. Daily, Michael D. Solga, Joanne A. Lannigan, and Alison K. Criss Jacqueline S. Stevens, Alison K. Criss
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Huy Q. Ta
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Denis Tebit
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Jeffrey J. Teoh
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Aditi Upadhye
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Koji Watanabe
55
Amber Woods
56
Maojin Yao
Huy Q Ta, Melissa L Ivey, Henry F Frierson Jr, Mark R Conaway, Jaroslaw Dziegielewski, James M Larner, and Daniel Gioeli Shannon Bush, Hamish Patel, Annette Ratcliff, Marie-‐Louise Hammarskjold, David Rekosh, Eric Arts, and Denis M. Tebit Jeffrey J. Teoh, Michael D. Stadnisky, Hideo Yagita, Timothy N.J. Bullock, and Michael G. Brown Aditi Upadhye, Sam Morris-‐Rosenfeld, Chantel McSkimming, Angela Taylor, Coleen McNamara Taiichiro Kobayashi and Koji Watanabe Amber Woods, Nithya Srivinasan, and Victor Engelhard Maojin Yao; Ying Jiang; Hui Zong
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Mitochondrial Maintenance: RalA Participation in Mitophagy Neisseria gonorrhoeae Muramidase Activity is Important for Survival from Neutrophils LPA-‐dependent regulation of VCAM-‐1 in the ovarian cancer metastatic microenvironment Dengue Virus Protease Drug Discovery: Screening Chemical Libraries, Using NMR to Study Reaction Chemistry, and the Use of Kinetic Simulations for Analysis of Steady State Kinetic Parameters Dissecting the signaling crosstalk between the Insulin-‐ like growth factor 1 and Sonic Hedgehog pathways in Medulloblastoma Using imaging flow cytometry to study N. gonorrhoeae phagocytosis by neutrophils Neutrophilic inflammation initiated by gonococcal-‐ endocervical cell interactions Checkpoint Kinase 2 is a Novel Regulator of Prostate Cancer Cell Growth
HIV-‐1 Group O Isolates Differ Greatly in their Susceptibility to Novel Antiretrovirals
Viral resistance by licensed NK enhances specific CD8+ T cell priming and differentiation Atheroprotective Potential of CXCR4 on B1 Cells
The impact of E. Histolytica infection on acute appendicitis Effector TCD8 use different receptor/ligand interactions to enter SC and IP B16 melanomas The supportive roles of tumor associated microglia/macrophage through IGF1 signaling pathway in Medulloblastoma
Microbiology, Immunology, and Cancer Biology 2015 Retreat
4:00
Reception/Activity
Details Coming Soon!
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Auditorium
Microbiology, Immunology, and Cancer Biology 2015 Retreat
Special Thanks to: Student Organizers: Stephanie Ragland Awndre Gamache Sowmya Narayanan Administrative Support: Liz Hupp Lynn McCutcheon Regina Seitz Sandy Weirich Susan Hennigan The Organizing Committee: Roger Abounader Alison Criss Loren Erickson David Kashatus Melissa Kendall Ulrike Lorenz Kwon Park Lucy Pemberton The MIC Departmental Chair: Kodi Ravichandran
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