Research Annual Report 2007 Netherlands Institute for Health Sciences (NIHES) Epidemiology of diseases Basic epidemiologic research Clinical epidemiology Effects of interventions on population health Determinants of population health Clinical research in general practice. Implementation of diagnostic and interventional imaging technology Assessment of diagnostic and interventional imaging technology Development of acquisition and processing techniques for diagnostic imaging Structuring of medical knowledge Structuring of medical data Assessment, aetiology and course of child and adolescent psychiatry

28760, B&T Ontwerp en advies (http://www.b-en-t.nl)

Research Annual Report 2007 Netherlands Institute for Health Sciences (NIHES) The dynamics of emotions and adaptation of (future) chronic patients Health care management (theme 3) Quality and efficiency in health care (theme 2) Competition and regulation in health care (theme 1)

28760, B&T Ontwerp en advies (http://www.b-en-t.nl)

EMC NIHES-01-64-01 - Epidemiology of diseases Programme design in brief This program includes scientific research in cardiovascular epidemiology, neuroepidemiology and ophthalmologic epidemiology. Cardiovascular epidemiologic research focuses on the determinants of atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women. The research is based on the Rotterdam Study and addresses inflammation markers and hemostasis as determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous hormones and hormone replacement therapy in women. Neuroepidemiologic research focuses on the etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the role of vascular factors in the etiology of these diseases, with use of state of the art neuroimaging techniques. Ophthalmological epidemiologic research focuses on determinants of macula degeneration and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in etiology of these diseases. Key figures Department epidemiology & biostatics

SP1

SP2

SP3

SP4

SPtot

7,15

3,42

1,5

0,08

12,15

neurology

0,08

0

0

0

0,08

radiology

0,42

0

0

0

0,42

Total

7,65

3,42

1,5

0,08

12,65

T1

T2

5

T3

1

Ttot

0

IS

6

FS

48

OP

1

Ptot

0

Theses Dijk, M.R. van (2007, maart 07). Methodological aspects of prognostic classifications: applications in testicular cancer. EUR (168 pag.). Prom./coprom.: Prof.Dr.Ir. J.D.F. Habbema & Prof.Dr. E.W. Steyerberg. Jong, F.J. de (2007, mei 23). Endoctrine factors, retinal vessels, and risk of dementia. EUR (199 pag.). Prom./coprom.: Prof.Dr. M.M.B. Breteler & Prof.Dr. P.T.V.M. de Jong. Kardys, I. (2007, december 19). Inflammatory markers and genes: epidemiologic studies on their roles in cardiovascular disease. EUR. Prom./coprom.: Dr. J.C.M. Witteman, Prof.Dr. A. Hofman & Dr. M.P.M. de Maat. Odink, A.E. (2007, januari 17). Epidemiologic studies on arterial calcification: The Rotterdam Study. EUR (131 pag.). Prom./coprom.: Prof.Dr. A. Hofman, Prof.Dr. G.P. Krestin, Dr. J.C.M. Witteman & A. van der Lugt. Oijen, M. van (2007, januari 31). Inflammation, vascular factors and risk of dementia. EUR (171 pag.). Prom./coprom.: Prof.Dr. M.M.B. Breteler & Prof.Dr. P.J. Koudstaal. Wagener, G. (2007, oktober 26). Calcium antagonists and hypertension: role of co-existent coronary disease, impaired renal function and diabetes. EUR (141 pag.). Prom./coprom.: Prof.Dr. J. Lubsen & Prof.Dr. A. Hofman Article/Letter to the editor Agt, H.M.E. van, Stege, H.A. van der, Ridder-Sluiter, J.G. de & Koning, H.J. de (2007). Detecting language problems: accuracy of five language screening instruments in preschool children. Developmental Medicine & Child Neurology, 49(2), 117-122. Benzo, R, Kelley, GA, Recchi, L, Hofman, A. & Sciurba, F (2007). Complications of lung resection and exercise capacity: meta-analysis. Respiratory Medicine, 101(8), 1790-1797. Berg, J.F. van den, Tulen, J.H.M., Neven, AK, Hofman, A., Miedema, HME, Witteman, J.C.M. & Tiemeier, H.W. (2007). Sleep duration and hypertension are not associated in the elderly. Hypertension, 50(3), 585-589. Boekhoorn, S.S., Vingerling, J.R., Witteman, J.C.M., Hofman, A. & Jong, P.T.V.M. de (2007). C-reactive protein level and risk of aging macula disorder - The Rotterdam study. Archives of Ophthalmology, 125(10), 1396-1401. Bornebroek, M., Lau, L.M.L. de, Haag, M.D.M., Koudstaal, P.J., Hofman, A., Stricker, B.H.C. & Breteler, M.M.B. (2007). Nonsteroidal anti-inflammatory drugs and the risk of parkinson disease. Neuroepidemiology, 28, 193-196. Bos, M.J., Koudstaal, P.J., Hofman, A. & Breteler, M.M.B. (2007). Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke - The Rotterdam study. Stroke, 38(12), 3127-3132. Bos, M.J., Rijn, M.J.E. van, Witteman, J.C.M., Hofman, A., Koudstaal, P.J. & Breteler, M.M.B. (2007). Incidence and prognosis of transient neurological attacks. Jama - Journal of the American Medical Association, 298(24), 2877-2885. Bos, M.J., Koudstaal, P.J., Hofman, A., Witteman, J.C.M. & Breteler, M.M.B. (2007). Transcranial Doppler Hemodynamic parameters and risk of stroke - The Rotterdam study. Stroke, 38(9), 2453-2458.

55

Bunge, E.M., Juttmann, R.E., Kleuver, M de, Biezen, F.C. van & Koning, H.J. de (2007). Health-related quality of life in patients with adolescent idiopathic scoliosis after treatment: short-term effects after brace or surgical treatment. European Spine Journal, 16(1), 83-89. Dehghan, A., Kardys, I., Maat, M.P.M. de, Uitterlinden, A.G., Sijbrands, E.J.G., Bootsma, A.H., Stijnen, T., Hofman, A., Schram, M.T. & Witteman, J.C.M. (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes, 56(3), 872-878. Dehghan, A., Hoek, M. van der, Sijbrands, E.J.G., Stijnen, T., Hofman, A. & Witteman, J.C.M. (2007). Risk of type 2 diabetes attributable to C-reactlve protein and other risk factors. Diabetes Care, 30(10), 2695-2699. Dijk, E.J. van, Prins, N.D., Hofman, A., Duijn, C.M. van, Koudstaal, P.J. & Breteler, M.M.B. (2007). Plasma beta amyloid and impaired CO2-induced cerebral vasomotor reactivity. Neurobiology of Aging, 28(5), 707-712. Frigerio, R, Breteler, M.M.B., Lau, L.M.L. de, Sanft, KR, Bower, JH, Ahlskog, JE, Grossardt, BR, Andrade, M de, Maraganore, D.M. & Rocca, W.A. (2007). Number of children and risk of Parkinson's disease. Movement Disorders, 22(5), 632-639. Geleijnse, J.M., Witteman, J.C.M., Stijnen, T., Kloos, M.W., Hofman, A. & Grobbee, D.E. (2007). Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study. European Journal of Epidemiology, 22(11), 763-770. Heeringa, J., Kuip, D.A.M. van der, Hofman, A., Kors, J.A., Rooij, F.J.A. van, Lip, G.Y.H. & Witteman, J.C.M. (2007). Subclinical atherosclerosis and risk of atrial fibrillation - The Rotterdam study. Archives of Internal Medicine, 167(4), 382387. Hofman, A., Breteler, M.M.B., Duijn, C.M. van, Krestin, G.P., Pols, H.A., Stricker, B.H.C., Tiemeier, H.W., Uitterlinden, A.G., Vingerling, J.R. & Witteman, J.C.M. (2007). The Rotterdam Study: Objectives and design update. European Journal of Epidemiology, 22(11), 819-829. Hulsman, C.A.A., Vingerling, J.R., Hofman, A., Witteman, J.C.M. & Jong, P.T.V.M. de (2007). Blood pressure, arterial stiffness, and open-angle glaucoma - The Rotterdam study. Archives of Ophthalmology, 125(6), 805-812. Iersel, C.A. van, Koning, H.J. de, Draisma, G., Mali, W.P.T.M., Scholten, ET, Nackaerts, K, Prokop, M, Habbema, J.D.F., Oudkerk, M. & Klaveren, R.J. van (2007). Risk-based selection from the general population in a screening trial: Selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON). International Journal of Cancer, 120(4), 868-874. Isaacs, A.J., Sayed-Tabatabaei, F.A., Hofman, A., Oostra, B.A., Klungel, O.H., Zee, AHMV, Stricker, B.H.C., Witteman, J.C.M. & Duijn, C.M. van (2007). The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study. European Journal of Cardiovascular Prevention & Rehabilitation, 14(3), 419-421. Jong, F.J. de, Ikram, M.K., Despriet, D.D.G., Uitterlinden, A.G., Hofman, A., Breteler, M.M.B. & Jong, P.T.V.M. de (2007). Complement factor H polymorphism, inflammatory mediators, and retinal vessel diameters: the Rotterdam study. Investigative Ophthalmology & Visual Science, 48, 3014-3018. Jong, F.J. de, Ikram, M.K., Witteman, J.C.M., Hoftnan, A, Jong, P.T.V.M. de & Breteler, M.M.B. (2007). Retinal vessel diameters and the role of inflammation in cerebrovascular disease. Annals of Neurology, 61(5), 491-495. Jong, F.J. de, Peeters, R.P., Heijer, T. den, Deure, W.M. van der, Hofman, A., Uitterlinden, A.G., Visser, T.J. & Breteler, M.M.B. (2007). The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe. Journal of Clinical Endocrinology and Metabolism, 92(2), 636-640. Kardys, I., Uitterlinden, A.G., Hofman, A., Witteman, J.C.M. & Maat, M.P.M. de (2007). Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: The Rotterdam Study. Thrombosis and Haemostasis, 97(2), 288-295. Kardys, I., Vliegenthart, R., Oudkerk, M., Hofman, A. & Witteman, J.C.M. (2007). The female advantage in cardiovascular disease: Do vascular beds contribute equally? American Journal of Epidemiology, 166(4), 403-412. Kardys, I., Maat, M.P.M. de, Klaver, C.C.W., Despriet, D.D.G., Uitterlinden, A.G., Hofman, A., Jong, P.T.V.M. de & Witteman, J.C.M. (2007). Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam study). American Journal of Cardiology, 100(4), 646-648. Koller, M.T., Steyerberg, E.W., Wolbers, M, Stijnen, T., Bucher, HC, Hunink, M.G.M. & Witteman, J.C.M. (2007). Validity of the Framingham point scores in the elderly: Results from the Rotterdam study. American Heart Journal, 154(1), 87-93. Lau, L.M.L. de, Refsum, H., Smith, AD, Johnston, C & Breteler, M.M.B. (2007). Plasma folate concentration and cognitive performance: Rotterdam scan study. American Journal of Clinical Nutrition, 86(3), 728-734.

Lau, L.M.L. de, Stricker, B.H.C. & Breteler, M.M.B. (2007). Serum cholesterol, use of lipid-lowering drugs, and risk of Parkinson Disease. Movement Disorders, 22(13), 1985-1985. Leeuwen, R. van, Eijkemans, M.J.C., Vingerling, J.R., Hofman, A., Jong, P.T.V.M. de & Simonsz, H.J. (2007). Risk of bilateral visual impairment in individuals with amblyopia: the Rotterdam study. British Journal of Ophthalmology, 91(11), 1450-1451. Mangunkusumo, R.T., Brug, J., Koning, H.J. de, Lei, J. van der & Raat, H. (2007). School-based Internet-tailored fruit and vegetable education combined with brief counselling increases children's awareness of intake levels. Public Health Nutrition, 10(3), 273-279. Mattace Raso, F.U.S., Meiracker, A.H. van den, Bos, W.J., Cammen, T.J.M. van der, Westerhof, B.E., Elias-Smale, S., Reneman, R.S., Hoeks, A.P.G., Hofman, A. & Witteman, J.C.M. (2007). Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam. Journal of Hypertension, 25(7), 1421-1426. Mattace Raso, F.U.S., Sie, M.P.S., Cammen, T.J.M. van der, Safar, ME, Hofman, A., Duijn, C.M. van & Witteman, J.C.M. (2007). Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study. Journal of Human Hypertension, 21(9), 736-740. Muskens, R.P.H.M., Voogd, S. de, Wolfs, R.C.W., Witteman, J.C.M., Hofman, A., Jong, P.T.V.M. de, Stricker, B.H.C. & Jansonius, N.M. (2007). Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology, 114(12), 2221-2226. Naarding, P., Tiemeier, H.W., Breteler, M.M.B., Schoevers, R.A., Jonker, C., Koudstaal, P.J. & Beekman, ATF (2007). Clinically defined vascular depression in the general population. Psychological Medicine, 37(3), 383-392. Odink, A.E., Lugt, A. van der, Hofman, A., Hunink, M.G.M., Breteler, M.M.B., Krestin, G.P. & Witteman, J.C.M. (2007). Association between calcification in the coronary arteries, aortic arch and carotid arteries: The Rotterdam study. Atherosclerosis, 193(2), 408-413. Oijen, M. van, Jong, F.J. de, Witteman, J.C.M., Hofman, A., Koudstaal, P.J. & Breteler, M.M.B. (2007). Atherosclerosis and risk for dementia. Annals of Neurology, 61(5), 403-410. Oijen, M. van, Maat, M.P.M. de, Kardys, I., Jong, F.J. de, Hofman, A., Koudstaal, P.J., Witteman, J.C.M. & Breteler, M.M.B. (2007). Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia. Neurobiology of Aging, 28(9), 1361-1366. Oijen, M. van, Jong, F.J. de, Hofman, A., Koudstaal, P.J. & Breteler, M.M.B. (2007). Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimers & Dementia, 3(2), 92-97. Poels, M.M.F., Oijen, M. van, Mattace Raso, F.U.S., Hofman, A., Koudstaal, P.J., Witteman, J.C.M. & Breteler, M.M.B. (2007). Arterial stiffness, cognitive decline, and risk of dementia - The Rotterdam study. Stroke, 38(3), 888-892. Reitz, C, Berger, K., Maat, M.P.M. de, Stoll, M., Friedrichs, F, Kardys, I., Witteman, J.C.M. & Breteler, M.M.B. (2007). CRP gene haplotypes, serum CRP, and cerebral small-vessel disease - The Rotterdam Scan Study and the MEMO study. Stroke, 38(8), 2356-2359. Reitz, C, Heijer, T. den, Duijn, C.M. van, Hofman, A. & Breteler, M.M.B. (2007). Relation between smoking and risk of dementia and Alzheimer disease - The Rotterdam Study. Neurology, 69(10), 998-1005. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B. (2007). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 7(5), 346352. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. British Journal of Clinical Pharmacology, 64(1), 57-66. Schram, M.T., Trompet, S, Kamper, A.M., Craen, AJM de, Hofman, A., Euser, S.M., Breteler, M.M.B. & Westendorp, R.G.J. (2007). Serum calcium and cognitive function in old age. Journal of American Geriatrics Society, 55(11), 17861792. Schram, M.T., Euser, S.M., Craen, AJM de, Witteman, JC, Frolich, M, Hofman, A., Jolles, J., Breteler, M.M.B. & Westendorp, R.G.J. (2007). Systemic markers of inflammation and cognitive decline in old age. Journal of American Geriatrics Society, 55(5), 708-716. Sie, M.P.S., Mattace Raso, F.U.S., Uitterlinden, A.G., Arp, P.P., Hofman, A., Hoeks, A.P.G., Reneman, R.S., Asmar, R., Duijn, C.M. van & Witteman, J.C.M. (2007). TGF-beta 1 polymorphisms and arterial stiffness; the Rotterdam Study. Journal of Human Hypertension, 21(6), 431-437.

Teichert, M., Smet, P.A.G.M. de, Hofman, A., Witteman, J.C.M. & Stricker, B.H.C. (2007). Discontinuation of beta-blockers and the risk of myocardial infarction in the elderly. Drug Safety, 30(6), 541-549. Vernooij, M.W., Ikram, M.A., Tanghe, H.L., Vincent, A.J.P.E., Hofman, A., Krestin, G.P., Niessen, W.J., Breteler, M.M.B. & Lugt, A. van der (2007). Incidental findings on brain MRI in the general population. New England Journal of Medicine, 357(18), 1821-1828. Vrooman, H.A., Cocosco, CA, Lijn, F. van der, Stokking, R., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B. & Niessen, W.J. (2007). Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification. Neuroimage, 37(1), 71-81.

EMC NIHES-01-64-02 - Basic epidemiologic research Programme design in brief This program includes research in the fields of genetic epidemiology and endocrinologic epidemiology. Genetic epidemiologic research aims at quantifying the population risk of disorders associated with genetic risk factors and at identifying new genetic factors involved in complex genetic disorders. For the empirical studies, the emphasis is on neurodegenerative and neurovascular disorders. The work in endocrinologic epidemiology focuses on the question whether circulating hormone levels are associated with incident diseases of the elderly and with parameters of frailty. The emphasis is on determinants of locomotor diseases (osteoporosis, osteoarthritis) and on sex hormones and thyroid hormones as determinants of disease. Key figures Department epidemiology & biostatics gynaecology/obstetrics Total

SP1

SP2

SP3

SP4

SPtot

3,94

1,99

1

0

6,93

0,2

0

0

0

0,2

4,14

1,99

1

0

7,13

T1

T2

8

T3

1

Ttot

0

IS

9

FS

56

OP

0

Ptot

0

Theses Boekhoorn, S.S. (2007, april 18). Environmental and genetic risk factors for aging macula disorder. EUR (135 pag.). Prom./coprom.: Prof.Dr. P.T.V.M. de Jong, Prof.Dr. A. Hofman & Dr. J.R. Vingerling. Feng, BJ (2007, november 29). A genetic epidemiological study of nasopharyngeal carcinoma. EUR (123 pag.). Prom./coprom.: D.E. Goldgar & Prof.Dr.Ir. C.M. van Duijn Gonzalez Zuloeta Ladd, A.M. (2007, september 05). Genetic determinants of breast cancer. EUR. Prom./coprom.: Prof.Dr. B.A. Oostra & Prof.Dr.Ir. C.M. van Duijn. Isaacs, A.J. (2007, mei 16). Genetic epidemiology and lipids: a pattern so grand and complex. EUR (173 pag.). Prom./coprom.: Prof.Dr.Ir. C.M. van Duijn & Prof.Dr. B.A. Oostra. Rijn, M.J.E. van (2007, april 11). Dissecting the genetics of stroke. EUR (167 pag.). Prom./coprom.: Prof.Dr. B.A. Oostra & Prof.Dr.Ir. C.M. van Duijn. Sanchez Juan, P.J. (2007, januari 24). Etiologic and diagnostic facets of Creutzfeldt-Jacob disease. The effect of genes and environment. EUR (183 pag.). Prom./coprom.: Prof.Dr.Ir. C.M. van Duijn, R.G. Will & J.M. Polo. Sie, M.P.S. (2007, juni 27). Genetic determinants of arterial stiffness. Results from the Rotterdam study. EUR (183 pag.). Prom./coprom.: Prof.Dr.Ir. C.M. van Duijn, Prof.Dr. B.A. Oostra & Dr. J.C.M. Witteman. Verburg, B.O. (2007, november 28). Fetal growth and development. The Generation R study. EUR. Prom./coprom.: Prof.Dr. E.A.P. Steegers, Prof.Dr. A. Hofman & Dr. V.W.V.K. Jaddoe. Yazdan Panah, M. (2007, december 05). Genetic determinants of homocysteine in relation to bone health. EUR. Prom./coprom.: Prof.Dr. H.A.P. Pols. Article/Letter to the editor Alizadeh, B.Z., Njajou, OT, Hazes, J.M.W., Hofman, A., Slagboom, P.E., Pols, H.A.P. & Duijn, C.M. van (2007). The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. Annals of the Rheumatic Diseases, 66(11), 1436-1442. Arias Vasquez, A., Lau, L.M.L. de, Pardo Cortes, L.M., Liu, F., Bertoli Avella, A.M., Isaacs, A.J., Aulchenko, Y., Hofman, A., Oostra, B.A., Breteler, M.M.B. & Duijn, C.M. van (2007). Relationship of the ubiquilin 1 gene with Alzheimer's and parkinson's disease and cognitive function. Neuroscience Letters, 424, 1-5. Arias-Vasquez, A, Isaacs, A.J., Aulchenko, Y.S., Hofman, A., Oostra, B.A., Breteler, M. & Duijn, C.M. van (2007). The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics, 8(3), 189-193. Aulchenko, Y.S., Ripke, S, Isaacs, A.J. & Duijn, C.M. van (2007). GenABEL: an R library for genorne-wide association analysis. Bioinformatics, 23(10), 1294-1296. Aulchenko, Y.S., Pullen, J., Kloosterman, WP, Yazdan Panah, M., Hofman, A., Vaessen, N., Snijders, P.J.L.M., Zubakov, D., Mackay, I, Olavesen, M, Sidhu, B, Smith, VE, Carey, A, Berezikov, E, Uitterlinden, A.G., Plasterk, R.H.A., Oostra, B.A. & Duijn, C.M. van (2007). LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition. Diabetes, 56(12), 3020-3026.

65

Berends, A.L., Bertoli Avella, A.M., Groot, C.J. de, Duijn, C.M. van, Oostra, B.A. & Steegers, E.A.P. (2007). STOX1 gene in pre eclampsia and intrauterine growth restriction. Bjog-An International Journal of Obstetrics and Gynaecology, 114, 1163-1167. Boccia, S, Lauretis, A De, Gianfagna, F, Duijn, C.M. van & Ricciardi, G. (2007). CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: a meta-analysis of the literature. Carcinogenesis, 28(1), 101-106. Boccia, S, Gianfagna, F, Persiani, R, Greca, A La, Arzani, D, Rausei, S, D'ugo, D, Magistrelli, P, Villari, P, Duijn, C.M. van & Ricciardi, G. (2007). Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population. Biomarkers, 12(6), 635-644. Boekhoorn, S.S., Vingerling, J.R., Uitterlinden, A.G., Meurs, J.B.J. van, Duijn, C.M. van, Pols, H.A.P., Hofman, A. & Jong, P.T.V.M. de (2007). Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. Investigative Ophthalmology & Visual Science, 48(3), 1012-1017. Boxmeer, J.C., Smit, M., Weber, R.F.A., Lindemans, J., Romijn, J.C., Eijkemans, M.J., Macklon, N.S. & SteegersTheunissen, R.P. (2007). Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. Journal of Andrology, 28(4), 521-527. Coppus, A.M.W., Fekkes, D., Verhoeven, W.M.A., Tuinier, S., Egger, JIM & Duijn, C.M. van (2007). Plasma amino acids and neopterin in healthy persons with Down's syndrome. Journal of Neural Transmission, 114(8), 1041-1045. Dijk, E.J. van, Prins, N.D., Hofman, A., Duijn, C.M. van, Koudstaal, P.J. & Breteler, M.M.B. (2007). Plasma beta amyloid and impaired CO2-induced cerebral vasomotor reactivity. Neurobiology of Aging, 28(5), 707-712. Ebisch, I.M.W., Steegers-Theunissen, R.P.M., Sweep, F.C.G.J., Zielhuis, G.A., Geurts-Moespot, A. & Thomas, C.M.G. (2007). Possible role of the plasminogen activation system in human subfertility. Fertility & Sterility, 87(3), 619-626. Ebisch, I.M.W., Thomas, C.M.G., Peters, W.H.M., Braat, D.D.M. & Steegers-Theunissen, R.P.M. (2007). The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Human Reproduction Update, 13(2), 163-174. Felix, J.F., Steegers-Theunissen, R.P.M., Walle, HEK de, Klein, A. de, Torfs, C.P. & Tibboel, D. (2007). Esophageal atresia and tracheoesophageal fistula in children of women exposed to diethylstilbestrol in utero. American Journal of Obstetrics and Gynecology, 197(1). Gonzalez Zuloeta Ladd, A.M., Arias Vasquez, A., Siemes, C., Yazdan Panah, M., Coebergh, J.W.W., Hofman, A., Stricker, B.H.C. & Duijn, C.M. van (2007). Differential roles of angiotensinogen and angiotensin receptor type 1 polymorphisms in breast cancer risk. Breast Cancer Research and Treatment, 101(3), 299-304. Gonzalez Zuloeta Ladd, A.M., Liu, F., Houben, M.P.W.A., Arias Vasquez, A., Siemes, C., Janssens, A.C.J.W., Coebergh, J.W.W., Hofman, A., Janssen, J.A.M.J.L., Stricker, B.H.C. & Duijn, C.M. van (2007). IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. European Journal of Cancer, 43(11), 1718-1722. Green, A., Sanchez-Juan, P, Ladogana, A., Cuadrado-Corrales, N, Sanchez-Valle, R., Mitrova, E., Stoeck, K, Sklaviadis, T, Kulczycki, J, Heinemann, U, Hess, K., Slivarichova, D, Saiz, A., Calero, M, Mellina, V, Knight, R, Duijn, C.M. van & Zerr, I. (2007). CSF analysis in patients with sporadic CJD and other transmissible spongiform encephalopathies. European Journal of Neurology, 14(2), 121-124. Hoppenbrouwers, I.A., Cortes, LMP, Aulchenko, Y.S., Sintnicolaas, K., Njajou, O, Snijders, P.J.L.M., Oostra, B.A., Duijn, C.M. van & Hintzen, R.Q. (2007). Familial clustering of multiple sclerosis in a Dutch genetic isolate. Multiple Sclerosis, 13(1), 17-24. Isaacs, A.J., Aulchenko, Y.S., Hofman, A., Sijbrands, E.J.G., Sayed-Tabatabaei, F.A., Klungel, O.H., Zee, AHMVD, Stricker, B.H.C., Oostra, B.A., Witteman, J.C.M. & Duijn, C.M. van (2007). Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. Journal of Clinical Endocrinology and Metabolism, 92(7), 2680-2687. Isaacs, A.J., Sayed-Tabatabaei, F.A., Aulchenko, Y.S., Zillikens, M.C., Sijbrands, E.J.G., Schut, A.F.C., Rutten, W.P.F., Pols, H.A.P., Witteman, J.C.M., Oostra, B.A. & Duijn, C.M. van (2007). Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: The Erasmus Rucphen Family Study. European Journal of Epidemiology, 22(2), 99-105. Isaacs, A.J., Sayed-Tabatabaei, F.A., Hofman, A., Oostra, B.A., Klungel, O.H., Zee, AHMV, Stricker, B.H.C., Witteman, J.C.M. & Duijn, C.M. van (2007). The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study. European Journal of Cardiovascular Prevention & Rehabilitation, 14(3), 419-421.

Jaddoe, V.W.V., Verburg, B.O., Ridder, M.A.J. de, Hofman, A., Mackenbach, J.P., Moll, H.A., Steegers, E.A.P. & Witteman, J.C.M. (2007). Maternal smoking and fetal growth characteristics in different periods of pregnancy. American Journal of Epidemiology, 165(10), 1207-1215. Jaddoe, V.W.V.K., Bakker, R., Hofman, A., Mackenbach, J.P., Moll, H.A., Steegers, E.A.P. & Witteman, J.C.M. (2007). Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The Generation R Study. Annals of Epidemiology, 17(10), 834-840. Jaddoe, V.W.V.K., Bakker, R., Duijn, C.M. van, Heijden, A.J. van der, Lindemans, J., Mackenbach, J.P., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2007). The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. European Journal of Epidemiology, 22(1), 917-923. Janssens, A.C.J.W., Moonesinghe, R, Yang, Q, Steyerberg, E.W., Duijn, C.M. van & Khoury, MJ (2007). The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genetics in Medicine, 9(8), 528-535. Koolwijk, L.M.E. van, Despriet, D.D.G., Duijn, C.M. van, Cortes, LMP, Vingerling, J.R., Aulchenko, Y.S., Oostra, B.A., Klaver, C.C.W. & Lemij, H.G. (2007). Genetic contributions to glaucoma: Heritability of intraocular pressure, retinal nerve fiber layer thickness, and optic disc morphology. Investigative Ophthalmology & Visual Science, 48(8), 3669-3676. Liu, F., Arias-Vasquez, A, Sleegers, K., Aulchenko, Y.S., Kayser, M.H., Sanchez-Juan, P, Feng, BJ, Bertoli-Avella, AM, Swieten, J. van, Axenovich, T.I., Heutink, P., Broeckhoven, C. van, Oostra, B.A. & Duijn, C.M. van (2007). A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. American Journal of Human Genetics, 81(1), 17-31. Min, JL, Meulenbelt, I., Kloppenburg, M, Duijn, C.M. van & Slagboom, P.E. (2007). Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis. European Journal of Human Genetics, 15(7), 791-799. Mook-Kanamori, D.O., Geelhoed, J.J.M., Steegers, E.A.P., Witteman, J.C.M., Hofman, A., Moll, H.A., Duijn, C.M. van & Hokken-Koelega, A.C.S. (2007). Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R study. European Journal of Endocrinology, 157, 741-748. Ridder, M.A.J. de, Stijnen, T. & Hokken-Koelega, A.C.S. (2007). A new method to determine mean adult height from incomplete follow-up data. Hormone Research, 67(4), 205-210. Ridder, M.A.J. de, Stijnen, T. & Hokken-Koelega, A.C.S. (2007). Prediction of adult height in growth-hormone-treated children with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 92(3), 925-931. Rijn, M.J.E. van, Schut, A.F.C., Aulchenko, Y.S., Deinum, J., Sayed-Tabatabaei, F.A., Yazdan Panah, M., Isaacs, A.J., Axenovich, T.I., Zorkoltseva, IV, Zillikens, M.C., Pols, H.A.P., Witteman, J.C.M., Oostra, B.A. & Duijn, C.M. van (2007). Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four bloodpressure-related genes. Journal of Hypertension, 25(3), 565-570. Rijn, M.J.E. van, Bos, M.J., Isaacs, A.J., Yazdan Panah, M., Arias Vasquez, A., Stricker, B.H.C., Klungel, O.H., Oostra, B.A., Koudstaal, P.J., Witteman, J.C.M., Hofman, A., Breteler, M.M.B. & Duijn, C.M. van (2007). Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Journal of Neurology Neurosurgery and Psychiatry, 78, 1083-1087. Rivadeneira Ramirez, F., Zillikens, M.C., Laet, CE De, Hofman, A., Uitterlinden, A.G., Beck, T.J. & Pols, H.A.P. (2007). Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: The Rotterdam study. Journal of Bone and Mineral Research, 22(11), 1781-1790. Roest, P.A.M., Iperen, L. van, Vis, S, Wisse, L.J., Poelmann, R.E., Steegers-Theunissen, R.P.M., Molin, DGM, Eriksson, UJ & Groot, A.C. de (2007). Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N-acetylcysteine. Birth Defects Research Part A-Clinical and Molecular Teratology, 79(3), 231235. Roza, S.J., Verburg, B.O., Jaddoe, V.W.V., Hofman, A., Mackenbach, J.P., Steegers, E.A.P., Witteman, J.C.M., Verhulst, F.C. & Tiemeier, H.W. (2007). Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study. European Journal of Neuroscience, 25(3), 611-617. Sanchez-Juan, P, Sanchez-Valle, R., Green, A., Ladogana, A., Cuadrado-Corrales, N, Mitrova, E., Stoeck, K, Sklaviadis, T, Kulczycki, J, Hess, K., Krasnianski, A, Equestre, M, Slivarichova, D, Saiz, A., Calero, M, Pocchiari, M., Knight, R, Duijn, C.M. van & Zerr, I. (2007). Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis. Journal of Neurology, 254(7), 901-906.

Sanchez-Juan, P, Houben, M.P.W.A., Hoff, J.I., Jansen, C.G., Sie, M.P.S., Rijn, M.J.E. van, Ironside, JW, Will, R.G., Duijn, C.M. van & Rozemuller, A (2007). The first case of variant Creutzfeldt-Jakob disease in the Netherlands. Journal of Neurology, 254(7), 958-960. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Yazdan Panah, M., Danser, A.H.J., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. European Journal of Human Genetics, 15(4), 478-484. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B. (2007). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 7(5), 346352. Silva, MCP, Janssens, A.C.J.W., Hofman, A., Witteman, J.C.M. & Duijn, C.M. van (2007). Cholesteryl ester transfer protein gene and coronary heart disease mortality: The rotterdam study. Journal of American Geriatrics Society, 55(9), 1483-1484. Sleegers, K., Koning, I. de, Aulchenko, Y.S., Rijn, M.J.E. van, Houben, M.P.W.A., Croes, E.A., Swieten, J.C. van, Oostra, B.A. & Duijn, C.M. van (2007). Cerebrovascular risk factors do not contribute to genetic variance of cognitive function The ERF study. Neurobiology of Aging, 28(5), 735-741. Smit, P., Dekker, M.J.H.J., Jong, F.J. de, Beld, A.W. van den, Koper, J.W., Pols, H.A.P., Brinkmann, A.O., Jong, F.H. de, Breteler, M.M.B. & Lamberts, S.W.J. (2007). Lack of association of the 11 beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. Journal of Clinical Endocrinology and Metabolism, 92(1), 359-362. Stolk, L., Meurs, J.B.J. van, Jhamai, M, Arp, P.P., Leeuwen, J.P.T.M. van, Hofman, A., Jong, F.H. de, Pols, H.A.P. & Uitterlinden, A.G. (2007). The catechol-O-methyltransferase Met(158) low-activity allele and association with nonvertebral fracture risk in elderly men. Journal of Clinical Endocrinology and Metabolism, 92(8), 3206-3212. Sutedja, NA, Sinke, R.J., Vught, PWJ Van, Linden, M.W. van der, Wokke, J.H.J., Duijn, C.M. van, Njajou, OT, Schouw, Y.T. van der, Veldink, J.H. & Berg, L.H. van den (2007). The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a dutch population. Archives of Neurology, 64(1), 63-67. Troe, J.W.M., Raat, H., Jaddoe, V.W.V.K., Hofman, A., Looman, C.W.N., Moll, H.A., Steegers, E.A.P., Verhulst, F.C., Witteman, J.C.M. & Mackenbach, J.P. (2007). Explaining differences in birthweight between ethnic populations. The generation R study. Bjog-An International Journal of Obstetrics and Gynaecology, 1557(1565). Verburg, B.O., Geelhoed, J.J.M., Steegers, E.A.P., Hofman, A., Moll, H.A., Witteman, J.C.M. & Jaddoe, V.W.V. (2007). Fetal kidney volume and its association with growth and blood flow in fetal life: The Generation R Study. Kidney International, 72(6), 754-761. Verkleij-Hagoort, A.C., Ursem, N.T., Hop, W.C., Geurts-Moespot, A., Steegers, E.A., Sweep, F.C. & SteegersTheunissen, R.P. (2007). Complex congenital malformations and the impact of the plasminogen activator system and beta-hCG in amniotic fluid. European Journal of Obstetrics, Gynecology and Reproductive Biology, 135(1), 47-52. Verkleij-Hagoort, A.C., Vries, JHM de, Stegers, MPG, Lindemans, J., Ursem, N.T.C. & Steegers-Theunissen, R.P.M. (2007). Validation of the assessment of folate and vitamin B-12 intake in women of reproductive age: the method of triads. European Journal of Clinical Nutrition, 61(5), 610-615. Visser, L.E., Schaik, R.H.N. van, Danser, A.H.J., Hofman, A., Witteman, J.C.M., Duijn, C.M. van, Uitterlinden, A.G., Pols, H.A.P. & Stricker, B.H.C. (2007). The risk of myocardial infarction in patients with reduced activity of cytochrome P4502C9. Pharmacogenetics Genomics, 17(7), 473-479. Vleuten, GM van der, Isaacs, A.J., Zeng, WW, Avest, E ter, Talmud, P.J., Dallinga-Thie, G.M., Duijn, C.M. van, Stalenhoef, A.F.H. & Graaf, J. van der (2007). Haplotype analyses of the APOA5 gene in patients with familial combined hyperlipidemia. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1772(1), 81-88. Vleuten, GM van der, Isaacs, A.J., Hijmans, A, Duijn, C.M. van, Stalenhoef, A.F.H. & Graaf, J. van der (2007). The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia. Journal of Lipid Research, 48(1), 193-200. Vujkovic, M., Ocke, M.C., Spek, P.J. van der, Yazdan Panah, M., Steegers, E.A. & Steegers-Theunissen, R.P. (2007). Maternal Western dietary patterns and the risk of developing a cleft lip with or without a cleft palate. Obstetrics and Gynecology, 110(2), 378-384. Yazdan Panah, M., Aulchenko, Y.S., Hofman, A., Janssen, J.A., Sayed-Tabatabaei, F.A., Schaik, R.H.N. van, Klungel, O.H., Stricker, B.H.C., Pols, H.A.P., Witteman, J.C.M., Lamberts, S.W.J., Oostra, B.A. & Duijn, C.M. van (2007). Effects of

the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes. Diabetes, 56, 1905-1912. Yazdan Panah, M., Rivadeneira Ramirez, F., Meurs, J.B.J. van, Zillikens, M.C., Arp, P., Hofman, A., Duijn, C.M. van, Pols, H.A.P. & Uitterlinden, A.G. (2007). The-1997 G/T and sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: The Rotterdam study. Calcified Tissue International, 81(1), 18-25.

EMC NIHES-01-64-03 - Clinical epidemiology Programme design in brief This program comprises three parts: clinical epidemiology in collaboration with radiology, biostatistics and pharmacoepidemiology. The clinical epidemiology group collaborates with the department of radiology in a joint research program for the Assessment of Radiological Technology (ART program). This program¿s research focuses on the assessment of medical imaging technology, especially diagnostic imaging but also image-guided therapies, with an emphasis on cardiovascular disease. Methodological research in the ART program focuses on developing the methods for evaluating diagnostic imaging procedures using stochastic modeling and utility assessment related to diagnostic testing and therapeutic outcomes. The biostatistics group provides quantitative support for various studies in the Erasmus MC. For its own research, the biostatistics group focuses on the application of new developments in statistics, such as new analytic methods for dependent observations, like random effect models, Baysian methods and sequential analysis. Pharmacoepidemiologic research focuses on intended effects of medications, and the effects of medication use under common circumstances in large populations. Key figures Department epidemiology & biostatics gastroenterology & hepatology immunology internal medicine Total

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SP2

SP3

SP4

SPtot

T1

6,25

4,32

0,25

0

10,82

0,2

0

0

0

0,2

1

0

0

0

1

0,5

0

0

0

0,5

7,95

4,32

0,25

0

12,52

T2

6

T3

0

Ttot

0

IS

6 116

FS

OP

10

Ptot

2

134

Theses Boks, S.S. (2007, maart 21). MRI Imaging in patients with knee injury: an observational study in general practice. EUR (139 pag.). Prom./coprom.: Prof.Dr. M.G.M. Hunink, Dr. S.M.A. Bierma-Zeinstra & Drs. D. Vroegindeweij. Kock, M.C.J.M. (2007, januari 24). Diagnostic imaging of peripheral arterial disease with multi-detector row computed tomography angiography. EUR. Prom./coprom.: Prof.Dr. M.G.M. Hunink & Prof.Dr. P.M.T. Pattynama. Siemes, C. (2007, mei 09). New insights into genetic variation and cancer. EUR. Prom./coprom.: Prof.Dr. H.A.P. Pols. Velde, N. van der (2007, mei 23). Falls in old age: pills, the heart and beyond; Withdrawal of drugs and screening for cardiovascular causes in older fallers. EUR. Prom./coprom.: Prof.Dr. B.H.C. Stricker, Prof.Dr. H.A.P. Pols & T.J.M. van der Cammen. Visser, J.J. (2007, november 14). Ruptured abdominal aortic aneurysms: endovascular repair versus open surgery. EUR. Prom./coprom.: Prof.Dr. M.G.M. Hunink, J.L. Bosch & Dr. M.R.H.M. van Sambeek. Ziere, G. (2007, december 05). Risk factors for falls and fall-related fractures in the elderly. EUR. Prom./coprom.: Prof.Dr. B.H.C. Stricker, Drs. J.P. Dieleman & T.J.M. van der Cammen. Article/Letter to the editor Aarnoudse, A.L.H.J., Dieleman, J.P. & Stricker, B.H.C. (2007). Age- and gender-specific incidence of hospitalisation for digoxin intoxication. Drug Safety, 30(5), 431-436. Aarnoudse, A.L.H.J., Dieleman, J.P. & Stricker, B.H.C. (2007). Age- and gender-specific incidence of hospitalisation for digoxin intoxication - The authors' reply. Drug Safety, 30(12), 1173-1174. Aarnoudse, A.L.H.J., Newton-Cheh, C, Bakker, PIW de, Straus, S.M.J.M., Kors, J.A., Hofman, A., Uitterlinden, A.G., Witteman, J.C.M. & Stricker, B.H.C. (2007). Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam study. Circulation, 116(1), 10-16. Aarnoudse, A.L.H.J., Straus, S.M.J.M., Hofman, A., Uitterlinden, A.G., Witteman, J.C.M., Stricker, B.H.C., Newton-Cheh, C, Kors, J.A. & Bakker, PIW de (2007). Response to letter regarding article, "Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study". Circulation, 116(24), E565-E565. Aarnoudse, A.L.H.J., Berge, H. van den, Bijl, A.M.H. & Stricker, B.H.C. (2007). Een lokale bijwerking van sublinguale immunotherapie. Ned. Tijdschrift voor Allergie, 2, 85-87. Bannink, E.M.N., Doorn, J. van, Mulder, P.G.H. & Hokken-Koelega, A.C.S. (2007). Free/dissociable insulin-like growth factor (IGF)-I, not total IGF-I, correlates with growth response during growth hormone treatment in children born small for gestational age. Journal of Clinical Endocrinology and Metabolism, 92(8), 2992-3000.

Becker, M.L., Caspers, PWJ, Kallewaard, M., Bruinink, RJ, Kylstra, NB, Heisterkamp, S., Valk, V. de, Veen, AA van der & Stricker, B.H.C. (2007). Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands. Pharmacy World & Science, 29(2), 51-57. Becker, M.L., Kallewaard, M., Caspers, PWJ, Visser, L.E., Leufkens, H.G.M. & Stricker, B.H.C. (2007). Hospitalisations and emergency department visits due to drug-drug interactions: a literature review. Pharmacoepidemiology and Drug Safety, 16(6), 641-651. Berg, W.J.B.W. van den, Hop, W.C.J., Strengers, J.L.M., Jongste, J.C. de, Osch-Gevers, M. van, Meijboom, F.J., Pattynama, P.M.T., Bogers, A.J.J.C. & Helbing, W.A. (2007). Clinical condition at mid-to-late follow-up after transatrial repair of tetralogy of Fallot. Journal of Thoracic and Cardiovascular Surgery, 133, 470-477. Bergmann, J.F., Vrolijk, J.M., Schaar, P van der, Vroom, B, Hoek, B. van, Veer, AV, Vries, R.A. de, Verhey, E, Hansen, B.E., Brouwer, J.T., Janssen, H.L.A., Schalm, S.W. & Knegt, R.J. de (2007). Gamma-glutamyltransferase and rapid virological response as predictors of successful treatment with experimental or standard peginterferon-alpha-2b in chronic hepatitis C non-responders. Liver International, 27(9), 1217-1225. Beukelaar, J.W. de, Sillevis Smitt, P.A.E., Hop, W.C., Kraan, J., Hooijkaas, H., Verjans, G.M.G.M. & Gratama, J.W. (2007). Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes. European Journal of Neurology, 14(12), 1383-1391. Birkenhager, T.K., Broek, W.W. van den, Fekkes, D., Mulder, P.G.H., Moleman, P. & Bruijn, J.A. (2007). Lithium addition in antidepressant-resistant depression: Effects on platelet 5-HT, plasma 5-HT and plasma 5-HIAA concentration. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31(5), 1084-1088. Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M. & Bierma-Zeinstra, S.M.A. (2007). Clinical consequences of posttraumatic bone bruise in the knee. American Journal of Sports Medicine, 35(6), 990-995. Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M.G.M. & Bierma-Zeinstra, S.M.A. (2007). MRI follow-up of posttraumatic bone bruises of the knee in general practice. American Journal of Roentgenology, 189(3), 556562. Bonjer, H.J., Hop, W.C.J., Nelson, H, Sargent, DJ, Lacy, A.M., Castells, A, Guillou, P.J., Thorpe, H, Brown, J., Delgado, S, Kuhrij, E., Haglind, E. & Pahlman, L. (2007). Laparoscopically assisted vs open colectomy for colon cancer - A metaanalysis. Archives of Surgery, 142(3), 298-303. Boogaard, R., Hulsmann, A.R., Veen, L. van, Vaessen-Verberne, AAPH, Yap, Y.N., Sprij, A.J., Brinkhorst, G.., Sibbles, B.J., Hendriks, T, Feith, S.W.W., Lincke, C.R., Brandsma, A.E., Brand, P.L.P., Hop, W.C.J., Hoog, M. de & Merkus, P.J.F.M. (2007). Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. Chest, 131, 788-795. Bos, I.C. van den, Hussain, S.M., Dwarkasing, R.S., Hop, W.C.J., Zondervan, P.E., Man, R.A. de, Ijzermans, J.N.M., Walker, CW & Krestin, G.P. (2007). MR Imaging of hepatocellular carcinoma: Relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. Jmri-Journal of Magnetic Resonance Imaging, 26(6), 1548-1555. Brink, J.L. van den, Moorman, P.W., Boer, M.F. de, Hop, W.C.J., Pruijn, J.F.A., Verwoerd, C.D.A. & Bemmel, J.H. van (2007). Impact on quality of life of a telemedicine system supporting head and neck cancer patients: A controlled trial during the postoperative period at home. Journal of the American Medical Informatics Association, 14(2), 198-205. Broek, W.W. van den, Birkenhager, T.K., Mulder, P.G.H., Mathot, R.A.A., Bruijn, J.A. & Moleman, P. (2007). Timedependent clearance decrements of fluvoxamine in depressed inpatients - A clinical evaluation. Journal of Clinical Psychopharmacology, 27(2), 231-233. Bruynzeel, H, Bruin, A.F.J. de, Bonjer, H.J., Lange, J.F., Hop, W.C.J., Ayodeji, I.D. & Kazemier, G. (2007). Desktop simulator: key to universal training? Surgical Endoscopy-Ultrasound and Interventional Techniques, 21(9), 1637-1640. Buster, E.H.C.J., Hansen, B.E., Buti, M, Delwaide, J., Niederau, C, Michielsen, P.P., Flisiak, R, Zondervan, P.E., Schalm, S.W. & Janssen, H.L.A. (2007). Peginterferon alpha-2b is safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis. Hepatology, 46(2), 388-394. Buysse, C.M.P., Raat, H., Hazelzet, J.A., Vermunt, L.C.A.C., Utens, E.M.W.J., Hop, W.C.J. & Joosten, K.F.M. (2007). Long-term health-related quality of life in survivors of meningococcal septic shock in childhood and their parents. Quality of Life Research, 16(10), 1567-1576. Callenbach, P.M.C., Pels, LPM, Mulder, P.G.H., Linssen, W.H.J.P., Gooskens, R.H.J.M., Zwan, JL van der & Brouwer, O.F. (2007). Sumatriptan nasal spray in the acute treatment of migraine in adolescents and children. European Journal of Paediatric Neurology, 11(6), 325-330.

Contant, C.M.E., Hop, W.C.J., Sant, HP van't, Oostvogel, HJM, Smeets, HJ, Stassen, LPS, Neijenhuis, PA, Idenburg, FJ, Dijkhuis, CM, Heres, P, Tets, WF van, Gerritsen, JJGM & Weidema, W.F. (2007). Mechanical bowel preparation for elective colorectal surgery: a multicentre randomised trial. Lancet (UK), 370(9605), 2112-2117. Dart, A.M., Otterstad, J.E., Kirwan, BA, Parker, J.D., Brouwer, S., Poole-Wilson, P.A. & Lubsen, J. (2007). Predictive value of local and core laboratory echocardiographic assessment of cardiac function in patients with chronic stable angina: The ACTION study. European Journal of Echocardiography, 8(4), 275-283. Delahanty, LM, Grant, RW, Wittenberg, E, Bosch, J.L., Wexler, DJ, Cagliero, E & Meigs, JB (2007). Association of diabetes-related emotional distress with diabetes treatment in primary care patients with Type 2 diabetes. Diabetic Medicine, 24(1), 48-54. Dieren, J.M. van, Hansen, B.E., Kuipers, E.J., Nieuwenhuis, E.E.S. & Woude, C.J. van der (2007). Meta-analysis: inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 26, 643-652. Dijk, M. van, Bannink, E.M.N., Pareren, Y.K. van, Mulder, P.G.H. & Hokken-Koelega, A.C.S. (2007). Risk factors for diabetes mellitus type 2 and metabolic syndrome are comparable for previously growth hormone-treated young adults born small for gestational age (SGA) and untreated short SGA controls. Journal of Clinical Endocrinology and Metabolism, 92(1), 160-165. Dooren, BTH van, Mulder, P.G.H., Nieuwendaal, C.P., Beekhuis, W.H. & Melles, G.R.J. (2007). Endothelial cell density after posterior lamellar keratoplasty: Five- to seven-year follow-up. American Journal of Ophthalmology, 144(3), 471-473. Duin, M. van, Marion, R. van, Vissers, KJ, Hop, W.C.J., Dinjens, W.N.M., Tilanus, H.W., Siersema, P.D. & Dekken, H. van (2007). High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. Cytogenetic and Genome Research, 118(2-4), 130-137. Fleuren, K.M.W., Smit, L.S., Stijnen, T. & Hartman, A (2007). New reference values for the Alberta Infant Motor Scale need to be established. Acta Paediatrica, 96(3), 424-427. Flink, H.J., Buster, E.H.C.J., Merican, I, Nevens, F., Kitis, G., Cianciara, J., Vries, R.A. de, Hansen, B.E., Schalm, S.W. & Janssen, H.L.A. (2007). Relapse after treatment with peginterferon a-2b alone or in combination with lamivudine in HBeAg positive chronic hepatitis B. Gut, 56(10), 1485-1486. Ghidey, W, Lesaffre, E. & Stijnen, T. (2007). Semi-parametric modelling of the distribution of the baseline risk in metaanalysis. Statistics in Medicine, 26(30), 5434-5444. Giessen, L.J. van der, Gosselink, R., Hop, W.C.J. & Tiddens, H.A.W.M. (2007). Recombinant human DNase nebulisation in children with cystic fibrosis: before bedtime or after waking up? European Respiratory Journal, 30(4), 763-768. Giessen, L.J. van der, Jongste, J.C. de, Gosselink, R., Hop, W.C.J. & Tiddens, H.A.W.M. (2007). RhDNase before airway clearance therapy improves airway patency in children with cf. Pediatric Pulmonology, 42, 624-630. Gonzalez Zuloeta Ladd, A.M., Arias Vasquez, A., Siemes, C., Coebergh, J.W.W., Hofman, A., Witteman, J.C.M., Uitterlinden, A., Stricker, B.H.C. & Duijn, C.M. van (2007). Transforming-growth factor beta(1) Leu10Pro polymorphism and breast cancer morbidity. European Journal of Cancer, 43(2), 371-374. Gosselink, M.P., Zimmerman, D.D., West, R.L., Hop, W.C., Kuipers, E.J. & Schouten, W.R. (2007). The effect of neorectal wall properties on functional outcome after colonic J-pouch-anal anastomosis. International Journal of Colorectal Disease, 22(11), 1353-1360. Groot Koerkamp, B., Hunink, M.G.M., Stijnen, T., Hammitt, J.K., Kuntz, K.M. & Weinstein, M.C. (2007). Limitations of acceptability curves for presenting uncertainty in cost-effectiveness analysis. Medical Decision Making, 27(2), 101-111. Han-Geurts, I.J.M., Hop, W.C., Verhoef, C., Tran, KTC & Tilanus, H.W. (2007). Randomized clinical trial comparing feeding jejunostomy with nasoduodenal tube placement in patients undergoing oesophagectomy. British Journal of Surgery, 94(1), 31-35. Han-Geurts, I.J.M., Hop, W.C.J., Kok, N.F.M., Lim, A., Brouwer, K.J. & Jeekel, J. (2007). Randomized clinical trial of the impact of early enteral feeding on postoperative ileus and recovery. British Journal of Surgery, 94(5), 555-561. Hansen, B.E., Rasmussen, AH, Jakobsen, BK, Ryder, L.P. & Svejgaard, A. (2007). Extraordinary cross-reactivity of an autoimmune T-cell receptor recognizing specific peptides both on autologous and on allogeneic HLA class II molecules. Tissue Antigens, 70(1), 42-52. Heijenbrok-Kal, M.H., Kock, M.C.J.M. & Hunink, M.G.M. (2007). Lower extremity arterial disease: Multidetector CT angiography - Meta-analysis. Radiology, 245(2), 433-439.

Heijenbrok-Kal, M.H., Fleischmann, K.E. & Hunink, M.G.M. (2007). Stress echocardiography, stress sing le-photonemission computed tomography and electron beam computed tomography for the assessment of coronary artery disease: A meta-analysis of diagnostic performance. American Heart Journal, 154(3), 415-423. Helvoort-Postulart, D van, Dirksen, C.D., Nelemans, P.J., Kroon, A.A., Kessels, A.G.H., Leeuw, P.W. de, Vasbinder, G.B.C., Engelshoven, J.M.A. van & Hunink, M.G.M. (2007). Renal artery stenosis: Cost-effectiveness of diagnosis and treatment. Radiology, 244(2), 505-513. Hempel, R.J., Tulen, J.H.M., Beveren, N.J.M. van, Mulder, P.G.H. & Hengeveld, M.W. (2007). Subjective and physiological responses to emotion-eliciting pictures in male schizophrenic patients. International Journal of Psychophysiology, 64(2), 174-183. Honore, C, Hummelshoj, T, Hansen, B.E., Madsen, H.O., Eggleton, P & Garred, P (2007). The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis & Rheumatism, 56(5), 1598-1607. Hou, J., Schilling, R, Janssen, H.L.A., Hansen, B.E., Heijtink, R., Sablon, E, Williams, R., Lau, GKK, Schalm, S.W. & Naoumov, N.V. (2007). Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearance. Journal of Medical Virology, 79(8), 1055-1063. Hovind, P, Lamberts, S., Hop, W., Deinum, J., Tarnow, L., Parving, HH & Janssen, J.A.M.J.L. (2007). An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes. European Journal of Endocrinology, 156(1), 83-90. Hutchison, A, Farmer, R, Verhamme, K., Berges, R & Navarrete, RV (2007). The efficacy of drugs for the treatment of LUTS/BPH, a study in 6 European countries. European Urology, 51(1), 207-216. Incrocci, L., Slob, A.K. & Hop, W.C.J. (2007). Tadalafil (Cialis) and erectile dysfunction after radiotherapy for prostate cancer: An open-label extension of a blinded trial. Urology, 70(6), 1190-1193. Jansen, A.J.G., Duvekot, J.J., Essink-Bot, M.L., Hop, W.C.J. & Rhenen, D.J. van (2007). Een klinisch multicentrisch onderzoek naar het optimale bloedtransfusiebeleid bij pati쬫nten met een fluxus post partum: de 'Wellbeing of obstetric patients on minimal blood transfusions (WOMB) study. Nederlands Tijdschrift voor Geneeskunde, 151, 2170-2172. Jansen, A.J.G., Duvekot, J.J., Hop, W.C.J., Essink-Bot, M.L., Beckers, E.A.M., Karsdorp, VHM, Scherjon, SA, Steegers, E.A.P. & Rhenen, D.J. van (2007). New insights into fatigue and health-related quality of life after delivery. Acta Obstetricia et Gynecologica Scandinavica, 86(5), 579-584. Kaandorp, G.C. & Koole, G. (2007). Optimal outpatient appointment scheduling. Health Care Management Science, 10(3), 217-229. Karger, R, Donner-Banzhoff, N, Muller, HH, Kretschmer, V & Hunink, M. (2007). Diagnostic performance of the platelet function analyzer (PFA-100 (R)) for the detection of disorders of primary haemostasis in patients with a bleeding history a systematic review and meta-analysis. Platelets, 18(4), 249-260. Kirwan, BA, Lubsen, J., Brouwer, S., Danchin, N., Battler, A., Luna, AB de, Dunselman, P.H.J.M., Glasser, S, Koudstaal, P.J., Sutton, G, Dalen, F.J. van & Poole-Wilson, P.A. (2007). Diagnostic criteria and adjudication process both determine published event-rates: The ACTION trial experience. Contemporary Clinical Trials, 28(6), 720-729. Kock, M.C.J.M., Dijkshoorn, M.L., Pattynama, P.M.T. & Hunink, M.G.M. (2007). Multi-detector row computed tomography angiography of peripheral arterial disease. European Radiology, 17(12), 3208-3222. Kok, E.T., Groeneveld, F.P.M.J., Busschbach, J.J.V. van, Hop, W.C.J., Bosch, J.L.H.R., Thomas, S. & Bohnen, A.M. (2007). Influence of coping styles on quality of life in men with new and increasing lower urinary tract symptoms. Urologia Internationalis, 79(3), 226-230. Kok, N.F.M., Smits - Lind, M.Y., Hansson, BME, Pilzecker, D, Mertens zur Borg, I.R.A.M., Knipscheer, BC, Hazebroek, E.J., Dooper, IM, Weimar, W., Hop, W.C.J., Adang, E.M.M., Wilt, G.J. van der, Bonjer, H.J., Vliet, J.A. van der & Ijzermans, J.N.M. (2007). Donor nephrectomy: less fatigue and better quality of life following laparoscopic kidney removal compared with an open procedure by mini-incision: blind randomised study. Nederlands Tijdschrift voor Geneeskunde, 151(24), 1352-1360. Korten, E, Toonder, I.M., Schrama, Y.C., Hop, W.C.J., Ham, AC van der & Wittens, C.H.A. (2007). Dialysis fistulae patency and preoperative diameter ultrasound measurements. European Journal of Vascular and Endovascular Surgery, 33(4), 467-471. Kros, J.M., Weiden, M.M. van der, Zheng, P., Hop, W.C., Bent, M.J. van den & Kouwenhoven, M.C.M. (2007). Intratumoral distribution of 1p loss in oligodendroglial tumors. Journal of Neuropathology and Experimental Neurology, 66(12), 1118-1123.

Liem, Y.S., Wong, J.B., Hunink, M.G.M., Charro, F. de & Winkelmayer, WC (2007). Comparison of hemodialysis and peritoneal dialysis survival in The Netherlands. Kidney International, 71(2), 153-158. Liem, Y.S., Bosch, J.L., Arends, L.R., Heijenbrok-Kal, M.H. & Hunink, M.G.M. (2007). Quality of life assessed with the medical outcomes study short form 36-item health survey of patients on renal replacement therapy: A systematic review and meta-analysis. Value in Health, 10(5), 390-397. Lubsen, J., Voko, Z., Poole-Wilson, P.A., Kirwan, BA & Brouwer, S. (2007). Blood pressure reduction in stable angina by nifedipine was related to stroke and heart failure reduction but not to coronary interventions. Journal of Clinical Epidemiology, 60(7), 720-726. Madaric, J, Vanderheyden, M, Laethem, C Van, Verhamme, K., Feys, A, Goethals, M, Verstreken, S, Geelen, P, Penicka, M, Bruyne, B. de & Bartunek, J (2007). Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance. European Heart Journal, 28(17), 2134-2141. Mos, M. de, Bruijn, A.G.J. de, Huygen, F.J.P.M., Dieleman, J.P., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). The incidence of complex regional pain syndrome: A population-based study. Pain, 129(1-2), 12-20. Mubarak, HS El, Yuksel, S., Amerongen, G. van, Mulder, P.G.H., Mukhtar, M.M., Osterhaus, A.D.M.E. & Swart, R.L. de (2007). Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses. Journal of General Virology, 88, 2028-2034. Niel-Weise, BS, Stijnen, T. & Broek, P.J.. van den (2007). Anti-infective-treated central venous catheters: a systematic review of randomized controlled trials. Intensive Care Medicine, 33(12), 2058-2068. Nout, E., Lange, J.F., Salu, NE, Wijsmuller, A.R., Hop, W.C.J., Goossens, R.H.M., Snijders, C.J., Jeekel, J. & Kleinrensink, G.J. (2007). Creep behavior of commonly used suture materials in abdominal wall surgery. Journal of Surgical Research, 138(1), 51-55. Nuijsink, M., Hop, W.C.J., Sterk, P.J., Duiverman, E.J. & Jongste, J.C. de (2007). Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial. European Respiratory Journal, 30, 457-466. Nuijsink, M., Hop, W.C.J., Sterk, P.J., Duiverman, E.J., Hiemstra, P.S. & Jongste, J.C. de (2007). Urinary eosinophil protein x in children with atopic asthma. Mediators of Inflammation, 2007, 1-6. Oei, E.H.G., Ginai-Karamat, A.Z. & Hunink, M.G.M. (2007). MRI for traumatic knee injury: A review. Seminars in Ultrasound Ct and Mri, 28(2), 141-157. Oosterom, F.J.T. van, Ettema, A.M., Mulder, P.G.H. & Hovius, S.E.R. (2007). Impairment and disability after severe hand injuries with multiple phalangeal fractures. Journal of Hand Surgery-American Volume, 32A(1), 91-95. Os, E. van, Broek, W.W. van den, Mulder, P.G.H., Borg, P.C.J. ter, Bruijn, J.A. & Buuren, H.R. van (2007). Depression in patients with primary biliary cirrhosis and primary sclerosing cholangitis. Journal of Hepatology, 46(6), 1099-1103. Plas, S.M. van der, Hansen, B.E., Boer, J.B. de, Stijnen, T., Passchier, J., Man, R.A. de & Schalm, S.W. (2007). Generic and disease-specific health related quality of life of liver patients with various aetiologies: A survey. Quality of Life Research, 16(3), 375-388. Poole-Wilson, P.A., Voko, Z., Kirwan, BA, Brouwer, S., Dunselman, P.H.J.M. & Lubsen, J. (2007). Clinical course of isolated stable angina due to coronary heart disease. European Heart Journal, 28(16), 1928-1935. Poole-Wilson, P.A., Kirwan, BA, Voko, Z., Brouwer, S., Dunselman, P.H.J.M., Dalen, F.J. van & Lubsen, J. (2007). Resource utilization implications of treatment were able to be assessed from appropriately reported clinical trial data. Journal of Clinical Epidemiology, 60(7), 727-733. Roder, E., Berger, M.Y., Hop, W.C.J., Bernsen, R.M.D., Groot, H. de & Wijk, R.G. van (2007). Sublingual immunotherapy with grass pollen is not effective in symptomatic youngsters in primary care. Journal of Allergy and Clinical Immunology, 119(4), 892-898. Roelfsema, N.M., Hop, W.C.J., Adrichem, L.N.A. van & Wladimiroff, J.W. (2007). Craniofacial variability index determined by three-dimensional ultrasound in isolated vs. syndromal fetal cleft lip/palate. Ultrasound in Obstetrics & Gynecology, 29(3), 265-270. Roelfsema, N.M., Hop, W.C.J., Adrichem, L.N.A. van & Wladimiroff, J.W. (2007). Craniofacial variability index in utero: a three-dimensional ultrasound study. Ultrasound in Obstetrics & Gynecology, 29(3), 258-264. Roelfsema, N.M., Grijseels, E.W.M., Hop, W.C.J. & Wladimiroff, J.W. (2007). Three-dimensional sonography of prenatal skull base development. Ultrasound in Obstetrics & Gynecology, 29(4), 372-377.

Roelofs, P.D.D.M., Bierma-Zeinstra, S.M.A., Poppel, M.N.M. van, Jellema, P., Willemsen, S.P., Tulder, M.W. van, Mechelen, W. van & Koes, B.W. (2007). Lumbar supports to prevent recurrent low back pain among home care workers A randomized trial. Annals of Internal Medicine, 147(10), 685-U112. Ruilope, LM, Kirwan, BA, Brouwer, S., Danchin, N., Fox, K.A.A., Wagener, G., Segura, J, Poole-Wilson, P.A. & Lubsen, J. (2007). Uric acid and other renal function parameters in patients with stable angina pectoris participating in the ACTION trial: impact of nifedipine GITS (gastro-intestinal therapeutic system) and relation to outcome. Journal of Hypertension, 25(8), 1711-1718. Sant, HP van't, Bouvy, N.D., Kazemier, G., Bonjer, H.J., Hop, W.C.J., Feelders, R.A., Herder, W.W. de & Krijger, R.R. de (2007). The prognostic value of two different histopathological scoring systems for adrenocortical carcinomas. Histopathology, 51(2), 239-245. Schat, A, Broek, W.W. van den, Mulder, P.G.H., Birkenhager, T.K., Tuijl, H.R. van & Murre, JMJ (2007). Changes in everyday and semantic memory function after electroconvulsive therapy for unipolar depression. Journal of Ect, 23(3), 153-157. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Yazdan Panah, M., Danser, A.H.J., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. European Journal of Human Genetics, 15(4), 478-484. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B. (2007). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 7(5), 346352. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. British Journal of Clinical Pharmacology, 64(1), 57-66. Schepers, T., Schipper, I.B., Vogels, L.M.M., Ginai-Karamat, A.Z., Mulder, P.G.H., Heetveld, M.J. & Patka, P. (2007). Percutaneous treatment of displaced intra-articular calcaneal fractures. Journal of Orthopaedic Science, 12(1), 22-27. Smeenk, H.G., Erdmann, J., Dekken, H. van, Marion, R. van, Hop, W.C.J., Jeekel, J. & Eijck, C.H.J. van (2007). Longterm survival after radical resection for pancreatic head and ampullary cancer: A potential role for the EGF-R. Digestive Surgery, 24(1), 38-45. Smeenk, H.G., Eijck, C.H.J. van, Hop, W.C., Erdmann, J., Tran, KCK, Debois, M., Cutsem, E. van, Dekken, H. van, Klinkenbijl, J.H. & Jeekel, J. (2007). Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation - Long-term results of EORTC trial 40891. Annals of Surgery, 246(5), 734740. Smit, M., Dohle, G.R., Hop, W.C.J., Wildhagen, M.F., Weber, R.F.A. & Romijn, J.C. (2007). Clinical correlates of the biological variation of sperm DNA fragmentation in infertile men attending an andrology outpatient clinic. International Journal of Andrology, 30(1), 48-55. Smits, M., Hunink, M.G.M., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Hofman, PAM, Twijnstra, A., Haan, G.G. de, Tanghe, H.L.J. & Dippel, D.W.J. (2007). A history of loss of consciousness or post-traumatic amnesia in minor head injury: "conditio sine qua non" or one of the risk factors? Journal of Neurology Neurosurgery and Psychiatry, 78(12), 13591364. Smits, M., Dippel, D.W.J. & Hunink, M.G.M. (2007). Cost effectiveness of using computed tomography (CT) for minor head injury compared with several other management strategies + reply. Journal of Trauma-Injury Infection and Critical Care, 62(5), 1314-1315. Smits, M., Dippel, D.W.J., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Minor head injury: Guidelines for the use of CT - A multicenter validation study. Radiology, 245(3), 831-838. Snoek, E.M. van der, Ossewaarde, J.M., Meijden, W.I. van der, Mulder, P.G.H. & Thio, H.B. (2007). The use of serological titres of IgA and IgG in (early) discrimination between rectal infection with nonlymphogranuloma venereum and lymphogranuloma venereum serovars of Chlamyclia trachlomatis. Sexually Transmitted Infections, 83(4). Soest, E.M. van, Sturkenboom, M.C.J.M., Dieleman, J.P., Verhamme, K.M.C., Siersema, P.D. & Kuipers, E.J. (2007). Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage. Alimentary Pharmacology & Therapeutics, 26(2), 265-275. Spronk, S., White, JV, Bosch, J.L. & Hunink, M.G.M. (2007). Impact of claudication and its treatment on quality of life. Seminars in Vascular Surgery, 20(1), 3-9.

Sutton, G.C., Otterstad, J.E., Kirwan, BA, Voko, Z., Brouwer, S., Lubsen, J. & Poole-Wilson, P.A. (2007). The development of heart failure in patients with stable angina pectoris. European Journal of Heart Failure, 9(3), 234-242. Teichert, M., Smet, P.A.G.M. de, Hofman, A., Witteman, J.C.M. & Stricker, B.H.C. (2007). Discontinuation of beta-blockers and the risk of myocardial infarction in the elderly. Drug Safety, 30(6), 541-549. Tilanus-Linthorst, M.M.A., Obdeijn, A.I.M., Hop, W.C.J., Causer, PA, Leach, MO, Warner, E., Pointon, L, Hill, K, Klijn, J.G.M., Warren, RML & Gilbert, FJ (2007). BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials. Clinical Cancer Research, 13(24), 73577362. Tjiong, H.L., Fieren, M.W., Rietveld, T., Wattimena, J.L.D., Schierbeek, H., Huijmans, J.G.M., Hop, W.C., Swart, G.R. & Berg, J.W.O. van den (2007). Albumin and whole-body protein synthesis respond differently to intraperitoneal and oral amino acids. Kidney International, 72(3), 364-369. Tjiong, H.L., Rietveld, T., Wattimena, J.L.D., Berg, J.W. van den, Kahriman, D., Steen, J. van der, Hop, W.C., Swart, R. de & Fieren, M.W. (2007). Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding. Clinical Journal of the American Society of Nephrology, 2(1), 74-80. Trifiro, G., Verhamme, K.M.C., Ziere, G., Caputi, AP, Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). All-cause mortality associated with atyical and typical antipsychotics in demented outpatients. Pharmacoepidemiology and Drug Safety, 16(5), 538-544. Twilt, M., Arends, L.R., Cate, R. ten & Suijlekom-Smit, L.W.A. van (2007). Incidence of temporomandibular involvement in juvenile idiopathic arthritis. Scandinavian Journal of Rheumatology, 36(3), 184-188. Vanhoenacker, PK, Heijenbrok-Kal, M.H., Heste, R Van, Decramer, I, Hoe, LR Van, William, W & Hunink, M.G.M. (2007). Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: Meta-analysis. Radiology, 244(2), 419-428. Veen, R.N. van, Wijsmuller, A.R., Vrijland, W.W., Hop, W.C., Lange, J.F. & Jeekel, J. (2007). Long-term follow-up of a randomized clinical trial of non-mesh versus mesh repair of primary inguinal hernia. British Journal of Surgery, 94(4), 506510. Veen, R.N. van, Wijsmuller, A.R., Vrijland, W.W., Hop, W.C.J., Lange, J.F. & Jeekel, J. (2007). Randomized clinical trial of mesh versus non-mesh primary inguinal hernia repair: Long-term chronic pain at 10 years. Surgery, 142(5), 695-698. Velde, N. van der, Stricker, B.H.C., Roelandt, J.R.T.C., Cate, F.J. ten & Cammen, T.J.M. van der (2007). Can echocardiographic findings predict falls in older persons? PLoS One, 2, 654. Velde, N. van der, Meiracker, A.H. van den, Stricker, B.H.C. & Cammen, T.J.M. van der (2007). Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant? Blood Pressure Monitoring, 12(3), 167-171. Velde, N. van der, Stricker, B.H.C., Pols, H.A.P. & Cammen, T.J.M. van der (2007). Withdrawal of fall-risk-increasing drugs in older persons - Effect on mobility test outcomes. Drugs & Aging, 24(8), 691-699. Velde, N. van der, Meiracker, A.H. van den, Pols, H.A.P., Stricker, B.H.C. & Cammen, T.J.M. van der (2007). Withdrawal of fall-risk-increasing drugs in older persons: Effect on tilt-table test outcomes. Journal of American Geriatrics Society, 55(5), 734-739. Veldt, B.J., Heathcote, E.J., Wedemeyer, H, Reichen, J., Hofmann, P, Zeuzem, S., Manns, M.P., Hansen, B.E., Schalm, S.W. & Janssen, H.L.A. (2007). Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Annals of Internal Medicine, 147(10), 677-U103. Verhamme, K.M.C. & Sturkenboom, M.C.J.M. (2007). Mortality in men admitted to hospital with acute urinary retention. British Medical Journal (International Edition), 335(7631), 1164-1165. Verhamme, K.M.C., Coster, W De, Roo, L De, Beenhouwer, H De, Nollet, G, Verbeke, J, Demeyer, I & Jordens, P (2007). Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia. Infection Control & Hospital Epidemiology, 28(4), 389-397. Verhamme, K.M.C., Mosis, G., Dieleman, J.P., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). Toegenomen kans op gastro-intestinale bloedingen of ulcera bij gebruik van spironolacton: patient-controlestudie. Nederlands Tijdschrift voor Geneeskunde, 151, 1515-1521. Verkleij-Hagoort, A.C., Ursem, N.T., Hop, W.C., Geurts-Moespot, A., Steegers, E.A., Sweep, F.C. & SteegersTheunissen, R.P. (2007). Complex congenital malformations and the impact of the plasminogen activator system and beta-hCG in amniotic fluid. European Journal of Obstetrics, Gynecology and Reproductive Biology, 135(1), 47-52.

Vermeulen, J., Akkersdijk, G.P., Gosselink, M.P., Hop, W.C.J., Mannaerts, GH, Harst, E. van der, Coene, PPLO, Weidema, W.F. & Lange, J.F. (2007). Outcome after emergency surgery for acute perforated diverticulitis in 200 cases. Digestive Surgery, 24(5), 361-366. Versnel, S.L., Mulder, P.G.H., Hovius, S.E.R. & Mathijssen, I.M.J. (2007). Measuring surgical outcomes in congenital craniofacial surgery: An objective approach. Journal of Craniofacial Surgery, 18(1), 120-126. Visser, L.E., Schaik, R.H.N. van, Danser, A.H.J., Hofman, A., Witteman, J.C.M., Duijn, C.M. van, Uitterlinden, A.G., Pols, H.A.P. & Stricker, B.H.C. (2007). The risk of myocardial infarction in patients with reduced activity of cytochrome P4502C9. Pharmacogenetics Genomics, 17(7), 473-479. Vries, A.C. de, Meijer, G.A., Looman, C.W.N., Casparie, M.K., Hansen, B.E., Grieken, N.C.T. van & Kuipers, E.J. (2007). Epidemiological trends of pre-malignant gastric lesions: a long-term nationwide study in the Netherlands. Gut, 56(12), 1665-1670. Vries, M. de, Ouwendijk, R., Flobbe, K., Nelemans, P.J., Kessels, A.G., Schurink, G.W., Vliet, J.A. van der, Cuypers, P.W.M., Duijm, L.E.M., Engelshoven, J.M.A. van, Hunink, M.G.M. & Haan, M.W. de (2007). Peripheral artery disease: clinical and cost comparison between duplex ultrasonography and contrast-enhanced magnetic resonance angiography a multicenter randomized trial. Nederlands Tijdschrift voor Geneeskunde, 151, 1789-1794. Wijffels, N.A.T., Walraven, LA van, Ophof, PJA, Hop, W.C.J., Harst, E. van der & Lange, J.F. (2007). Late development of pancreas necrosis during acute pancreatitis - An underestimated phenomenon associated with high morbidity and mortality. Pancreas, 34(2), 215-219. Wijsmuller, A.R., Veen, R.N. van, Bosch, J.L., Kleinrensink, G.J., Jeekel, J. & Lange, J.F. (2007). Nerve management during open hernia repair. British Journal of Surgery, 94(1), 17-22. Wijsmuller, A.R., Lange, J.F., Geldere, D. van, Simons, MP, Kleinrensink, G.J., Hop, W.C.J. & Jeekel, J. (2007). Surgical techniques preventing chronic pain after Lichtenstein hernia repair: state-of-the-art vs daily practice in the Netherlands. Hernia, 11(2), 147-151. Willemsen, R.H., Dijk, M. van, Rijke, Y.B. de, Toorenenbergen, A.W. van, Mulder, PG & Hokken-Koelega, A.C. (2007). Effect of growth hormone therapy on serum adiponectin and resistin levels in short, small-for-gestational-age children and associations with cardiovascular risk parameters. Journal of Clinical Endocrinology and Metabolism, 92(1), 117-123. Wolvius, E.B., Scholtemeijer, M., Weijland, M, Hop, W.C.J. & Wal, K.G.H. van der (2007). Complications and relapse in alveolar distraction osteogenesis in partially dentulous patients. International Journal of Oral and Maxillofacial Surgery, 36(8), 700-705. Zheng, P., Hop, W.C., Luider, T.M., Sillevis Smitt, P.A.E. & Kros, J.M. (2007). Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas. Annals of Neurology, 62(1), 4048. Ziere, G., Dieleman, J.P., Cammen, T.J.M. van der & Stricker, B.H.C. (2007). Association between SSRI use and fractures and the effect of confounding by indication. Archives of Internal Medicine, 167(21), 2369-2370.

EMC NIHES-02-65-01 - Effects of interventions on population health Programme design in brief The focus of this programme is on prediction and evaluation of the effects of health interventions on morbidity and mortality in their target populations, and on relating these health effects to economic consequences in cost-effectiveness studies. The research programme is broken down into: - Secondary prevention. Three types of study are undertaken: (1) Monitoring and evaluation of ongoing screening programmes and randomised trials. (2) Prospective evaluation of screening strategies, with emphasis on impact on morbidity and mortality and on costeffectiveness ratios. (3) Analysis of new developments and research questions. Specific fields are cancer, child health surveillance, developmental disorders and genetic disorders. - Infectious diseases. Research is focused on collection and analysis of empirical data, and development and application of models for the epidemiology and control of important infectious diseases of the tropical zone (onchocerciasis, lymmphatic filariasis, schistosomiasis, leprosy, tuberculosis, malaria and sexually transmitted diseases, including AIDS and in the Western context Hepatitis A, B and C, STD"s and import diseases). - Interventions in clinical populations. Three questions are studied: what is wrong with the patients? (diagnostics), what can be done about it? (therapy choice), and what will happen? (prognosis). Emphasis is on studying prognosis. - Medical decisions concerning the end of life. This part of the research programme aims to describe and explain medical care and decision-making at the end of life. - Trends in population health. Changes in population health status and health care costs as a consequence of changes in medical care and risk factor exposure. Methodological issues, including: development and application of dynamic age-structured population health models; standardization of research methodology with respect to descriptive health status measurement, development and application of statistical methods for prognostic modelling; and methodological aspects of use and optimization of microsimulation modelling, an approach which is often applied in this research programme. Key figures Department

SP1

SP2

SP3

SP4

SPtot

public health

3,99

12,84

8,43

5,81

31,07

pulmonology

0

0

0,14

0

0,14

3,99

12,84

8,57

5,81

31,21

Total

T1

T2

7

T3

0

Ttot

0

IS

FS

7 151

OP

16

Ptot

20

194

Theses Bijma, H.H. (2007, mei 30). Decision-making after ultrasound diagnosis of fetal abnormality. EUR (120 pag.). Prom./coprom.: Prof.Dr. P.J. van der Maas, Prof.Dr. J.W. Wladimiroff, Dr. A. van der Heide & Dr. H.I.J. Wildschut. Dijk, M.R. van (2007, maart 07). Methodological aspects of prognostic classifications: applications in testicular cancer. EUR (168 pag.). Prom./coprom.: Prof.Dr.Ir. J.D.F. Habbema & Prof.Dr. E.W. Steyerberg. Hest, N.A.H. van (2007, september 14). Capture-recapture methods in surveillance of tuberculosis and other infectious diseases. EUR (188 pag.). Prom./coprom.: Prof.Dr.Ir. J.D.F. Habbema & Dr. J.H. Richardus. Houdenhoven, M. van (2007, december 19). Healthcare logistics: the art of balance. EUR (280 pag.). Prom./coprom.: Prof.Dr. E.W. Steyerberg, Prof.Dr. H.W. Tilanus & G. Kazemier. Madalinska, J.B. (2007, januari 24). Psychosocial and quality of life issues in prostate and ovarian cancer. EUR. Prom./coprom.: Prof.Dr. P.J. van der Maas & N.K. Aaronson. Moet, F.J. (2007, september 20). Contacts of leprosy patients: occurrence and prevention of the disease. EUR (131 pag.). Prom./coprom.: Prof.Dr.Ir. J.D.F. Habbema & Dr. J.H. Richardus. Verschuur, E.M.L. (2007, oktober 11). Nurse-led follow-up and palliative care of esophageal cancer patients. EUR (201 pag.). Prom./coprom.: Prof.Dr. E.J. Kuipers & Prof.Dr. E.W. Steyerberg. Article/Letter to the editor Abeku, T.A. (2007). Response to malaria epidemics in Africa. Emerging Infectious Diseases, 13(5), 681-686. Agt, H.M.E. van, Stege, H.A. van der, Ridder-Sluiter, H de, Verhoeven, L.T.W. & Koning, H.J. de (2007). A clusterrandomized trial of screening for language delay in toddlers: Effects on school performance and language development at age 8. Pediatrics, 120(6), 1317-1325.

Agt, H.M.E. van, Stege, H.A. van der, Ridder-Sluiter, J.G. de & Koning, H.J. de (2007). Detecting language problems: accuracy of five language screening instruments in preschool children. Developmental Medicine & Child Neurology, 49(2), 117-122. Baalbergen, A., Ewing-Graham, P.C., Eijkemans, M.J. & Helmerhorst, T.J.M. (2007). Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality. International Journal of Cancer, 121(1), 106110. Baart, E.B., Martini, E., Eijkemans, M.J., Opstal, D. van, Beckers, N.G.M., Verhoeff, A., Macklon, N.S. & Fauser, B.C.J.M. (2007). Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Human Reproduction, 22(4), 980-988. Battin, MP, Heide, A. van der, Ganzini, L, Wal, G. van der & Onwuteaka-Philipsen, B.D. (2007). Legal physician-assisted dying in Oregon and the Netherlands: evidence concerning the impact on patients in "vulnerable'' groups. Journal of Medical Ethics, 33(10), 591-597. Beek, J.G.M. van, Mushkudiani, N., Steyerberg, E.W., Butcher, I, McHugh, GS, Lu, J., Marmarou, A., Murray, G.D. & Maas, A.I.R. (2007). Prognostic value of admission laboratory parameters in traumatic brain injury: Results from the IMPACT study. Journal of Neurotrauma, 24(2), 315-328. Berkers, L.M., Ballegooijen, M. van, Kemenade, F.J. van, Rebolj, M., Essink-Bot, M.L., Helmerhorst, T.J.M. & Habbema, J.D.F. (2007). Herziening bevolkingsonderzoek op baarmoederhalskanker 1996: hogere dekkingsgraad, minder herhalingsuitstrijkjes en minder opportunistische screening. Nederlands Tijdschrift voor Geneeskunde, 151(23), 12881294. Bhatnagar, V., Stoto, M.A., Morton, S.C., Boer, R. & Bozzette, S.A. (2006). 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Steyerberg, E.W. (2007). Epidemiology of tumour markers: screening, diagnosis and prognosis. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde, 32, 79-82. Takkenberg, J.J.M., Klieverik, L.M.A., Bekkers, J.A., Kappetein, A.P., Roos-Hesselink, J.W., Eijkemans, M.J.C. & Bogers, A.J.J.C. (2007). Allografts for aortic valve or root replacement: insights from an 18-year singte-center prospective followup study. European Journal of Cardio-Thoracic Surgery, 31(5), 851-858. Veen, N.H.J. van, Nicholls, P.G., Smith, W.C.S. & Richardus, J.H. (2007). Corticosteroids for treating nerve damage in leprosy. Cochrane Database Systems Review. Veerbeek, L., Zuylen, L. van, Swart, S.J., Maas, P.J. van der & Heide, A. van der (2007). The last 3 days of life in three different care settings in The Netherlands. Supportive Care in Cancer, 15(10), 1117-1123. Velde, E.R. te, Habbema, J.D.F., Hilders, C.G. & Merkus, J.M.W.M. (2007). Gevolgen van uitstel van zwangerschap. Nederlands Tijdschrift voor Geneeskunde, 151(28), 1593-1596. Veldhuijzen, I.K., Mostert, M.C., Niesters, H.G.M., Richardus, J.H. & Man, R.A. de (2007). Accuracy of a referral guideline for patients with chronic hepatitis B in primary care to select patients eligible for evaluation by a specialist. Gut, 56(7), 1027-1028. Verberg, MFG, Eijkemans, M.J.C., Macklon, N.S., Heijnen, E.M.E.W., Fauser, B.C.J.M. & Broekmans, F.J.M. (2007). Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF. Human Reproduction, 22(7), 19191924. Vergouwe, Y., Steyerberg, E.W., Foster, R.S., Sleijfer, D.T., Fossa, S.D., Gerl, A., Wit, R. de, Roberts, J.T. & Habbema, J.D.F. (2007). Predicting retroperitoneal histology in postchemotherapy testicular germ cell cancer: A model update and multicentre validation with more than 1000 patients. European Urology, 51(2), 424-432. Verschuur, E.M.L., Steyerberg, E.W. & Kuipers, E.J. (2007). Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer (vol 65, pg 592, 2007). Gastrointestinal Endoscopy, 66(1), 211-212. Vliet, E.P.M. van, Steyerberg, E.W., Eijkemans, M.J.C., Kuipers, E.J. & Siersema, P.D. (2007). Detection of distant metastases in patients with oesophageal or gastric cardia cancer: a diagnostic decision analysis. British Journal of Cancer, 97, 868-876. Vliet, E.P.M. van, Eijkemans, M.J.C., Kuipers, E.J., Poley, J.W., Steyerberg, E.W. & Siersema, P.D. (2007). Publication bias does not play a role in the reporting of the results of endoscopic ultrasound staging of upper gastrointestinal cancers. Endoscopy, 39(4), 325-332. Voeten, H.A.C.M., Egesah, O.B., Varkevisser, C.M. & Habbema, J.D.F. (2007). Female sex workers and unsafe sex in urban and rural Nyanza, Kenya: regular partners may contribute more to HIV transmission than clients. Tropical Medicine and International Health, 12(2), 174-182. Vogel- Voogt, E. de, Heide, A. van der, Leeuwen, A.F. van, Visser, A.P., Rijt, C.C.D. van der & Maas, P.J. van der (2007). Patient evaluation of end-of-life care. Palliative Medicine, 21(3), 243-248. Vogel- Voogt, E. de, Leeuwen, A. van, Visser, A.P. & Heide, A. van der (2007). Leven tot het einde: kankerpatienten in de laatste levensfase. Tijdschrift Kanker, 31, 12-14. Vrakking, A.M., Heide, A. van der, Provoost, V, Bilsen, J, Wal, G. van der & Deliens, L. (2007). End-of-life decision making in neonates and infants: comparison of the Netherlands and Belgium (Flanders). Acta Paediatrica, 96(6), 820-824. Vrakking, A.M., Heide, A. van der, Onwuteaka-Philipsen, B.D., Maas, P.J. van der & Wale, G van der (2007). Regulating physician-assisted dying for minors in the Netherlands: views of paediatricians and other physicians. Acta Paediatrica, 96(1), 117-121. Vries, G. de, Hest, N.A.H. van & Richardus, J.H. (2007). Impact of mobile radiographic screening on tuberculosis among drug users and homeless persons. American Journal of Respiratory and Critical Care Medicine, 176(2), 201-207. Vries, S.H. de, Postma, R., Raaijmakers, R., Roemeling, S., Otto, S, Koning, H.J. de & Schroder, F.H. (2007). Overall and disease-specific survival of patients with screen-detected prostate cancer in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. European Urology, 51(2), 366-374. White, R.G., Cooper, BS, Kedhar, A, Orroth, K.K., Biraro, S, Baggaley, RF, Whitworth, J, Korenromp, E.L., Ghani, A, Boily, MC & Hayes, R.J. (2007). Quantifying HIV-1 transmission due to contaminated injections. Proceedings of the National Academy of Sciences of the United States of Ame, 104(23), 9794-9799. Wiel, J.C.M., Wang, Y., Xu, DM, Zaag-Loonen, H.J. van der, Jagt, E.J. van der, Klaveren, R.J. van, Oudkerk, M. & NELSON study group, - (2007). Neglectable benefit of searching for incidental findings in the Dutch-Belgian lung cancer screening trial (NELSON) using low-dose multidetector CT. European Radiology, 17, 1474-1482.

Wildiers, H, Kunkler, I, Biganzoli, L., Fracheboud, J., Vlastors, G, Bernard-Marty, C, Hurria, A, Extermann, M, Girre, V, Brain, E, Audisio, RA, Bartelink, H., Barton, M, Giordano, SH, Muss, H & Aapro, M (2007). Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncology, 8(12), 11011115. Wolfers, MEG, Hoek, C. van der, Brug, J. & Zwart, O. de (2007). Using Intervention Mapping to develop a programme to prevent sexually transmittable infections, including HIV, among heterosexual migrant men. Bmc Public Health, 7. Yu, J.M., Vlas, S.J. de, Jiang, QW & Gryseels, B. (2007). Comparison of the Kato-Katz technique, hatching test and indirect hemagglutination assay (IHA) for the diagnosis of Schistosoma japonicum infection in China. Parasitology International, 56(1), 45-49. Zwart, O. de, Veldhuijzen, I.K., Elam, G, Aro, A.R., Abraham, T, Bishop, G.D., Richardus, J.H. & Brug, J. (2007). Avian influenza risk perception, Europe and Asia. Emerging Infectious Diseases, 13(2), 290-293. Part of book - abstract Fracheboud, J. & Int. Cancer Screening Netw., - (2007). Chapter. In N. Segnan, N. Ohuchi, A. Scharpantgen & R. BallardBarbash (Eds.), Designing print materials: a communication guide for breast cancer screening (pp. 1-120). NIH/NCI: Bethesda. Fracheboud, J., Groenewoud, J.H. & Koning, H.J. de (2007). Fifteen years of population-based breast cancer screening in the Netherlands. In J.W. Smith (Ed.), Seminars in breast disease (pp. 72-82). --: --. Fracheboud, J., Groenewoud, J.H. & Koning, H.J. de (2007). Bevolkingsonderzoek naar mammacarcinooom. In T. Wobbes, J.W.R. Nortier & C.C.E. Koning (Eds.), Handboek mammacarcinoom (pp. 43-61). Utrecht: De Tijdstroom. Koning, H.J. de & Fracheboud, J. (2007). Gezondheidszorgonderzoek op het terrein van secundaire preventie. In T. Plochg, R.E. Jutmann, N.S. Klazinga & J.P. Mackenbach (Eds.), handboek geozndheidszorgonderzoek (pp. 334-344). Houten: Bohn Stafleu van Loghum. Koning, H.J. de & Landelijk Evaluatie Team Bevolkingsonderzoek, LETB (2007). Tussenrapportage 2006. Belangrijkste resultaten bevolkingsonderzoek borstkanker. In R Pijnappel (Ed.), Syllabus mammadiagnostiek en Interventie nr. 58 (pp. 37). s'Hertogenbosch: EduRad. Rigter, H.G.M. (2007). Problematisch gebruik van cannabis en alcohol. In F. Verheij, F.C. Verhulst & R.F. Ferdinand (Eds.), Kinder- en jeugdpsychiatrie: behandeling en begeleiding (pp. 406-432). Assen: Koninklijke van Gorcum. Internal report Agt, H.M.E. van, Schoonen, H.M.H.J.D., Wildschut, H.I.J., Koning, H.J. de & Essink-Bot, M.L. (2007). Voorlichting voor pre- en neonatale screeningsprogramma's: vragenlijsten voor landelijke evaluatie van de aanbiedingsprocedure. 1-112007. public health. Gelder, R de, Draisma, G., Fracheboud, J. & Koning, H.J. de (2007). Cost-effectiveness of mammography screening in Switzerland; a micro-simulation analysis. october 2007. public health. External report Fracheboud, J. & Koning, H.J. de (2007). Digitale pilots: vergelijking analoge en digitale screeningsperformance van drie digitale pilots in het Nederlandse bevolkingsonderzoek naar borstkanker. Bilthoven: RIVM. Koning, H.J. de (2007). Richtlijn screening en dignostiek van het mammacarcinoom. Utrecht: Kwaliteitsinstituut voor de gezondheidszorg CBO en vereniging van Integrale kankercentra.

EMC NIHES-02-65-02 - Determinants of population health Programme design in brief Problem Definition: The focus of this research programme is on the explanation of patterns of disease and mortality in populations. Three questions are addressed: - How can (changes in) patterns of mortality, disease and risk factors be measured effectively ? - What factors determine these (changes in) patterns? - To what extent can health policy including health promotion interventions influence these patterns of disease and mortality? Five groups of determinants are being studied: - social factors, such as socioeconomic status and marital status; - demographic factors, such as ageing; - health-related behaviors, such as diet and smoking; - work-related factors; such as physical load and chemical agents - medical care. Key figures Department epidemiology & biostatics public health rheumatology Total

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0

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0

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Theses Houweling, A.J. (2007, september 05). Socio-economic inequalities in childhood mortality in low and middle income countries. EUR (293 pag.). Prom./coprom.: Prof.Dr. J.P. Mackenbach & Dr. A.E. Kunst. Lanting, L.C. (2007, februari 09). Ethnic differences in utilization of an outpatient clinic in The Netherlands - a study of diabetes patients and patients with gastrointestinal symptoms. EUR (138 pag.). Prom./coprom.: Prof.Dr. J.P. Mackenbach, Prof.Dr. S.W.J. Lamberts, Dr. I.M.A. Joung & Dr. A.H. Bootsma. Lemmens, V.E.P.P. (2007, oktober 24). Clinical epidemiology of colorectal cancer in the Netherlands : studies of variation and trends with the Eindhoven Cancer Registry. EUR (169 pag.). Prom./coprom.: Prof.Dr. J.W.W. Coebergh & M.L.G. Janssen - Heynen. Louwman, W.J. (2007, juni 06). Breast cancer incidence and survival: registry-based studies of long-term trends and determinants. EUR (208 pag.). Prom./coprom.: Prof.Dr. J.W.W. Coebergh. Polinder, S. (2007, januari 10). Economic and health impact of injuries in The Netherlands and Europe. EUR (192 pag.). Prom./coprom.: Prof.Dr.Ir. J.D.F. Habbema, Dr. E.F. van Beeck & Drs. W.J. Meerding. Soerjomataram, I. (2007, december 20). Multiple primary cancers in patients with breast and skin cancer. EUR (209 pag.). Prom./coprom.: Prof.Dr. J.W.W. Coebergh & Ir. W.J. Louwman. Veerman, J.L. (2007, september 12). Quantitative health impact assessment: an exploration of methods and validity. EUR (194 pag.). Prom./coprom.: Prof.Dr. J.P. Mackenbach & Dr. J.J.M. Barendregt. Wammes, B.M. (2007, februari 14). Evaluation of a nationwide mass media campaign aimed at prevention of weight gain in Dutch young adults. EUR (162 pag.). Prom./coprom.: Prof.Dr.Ir. J. Brug. Article/Letter to the editor Abdalla, AM, Al-Kaabba, AF, Saeed, AA, Abdulrahman, BM & Raat, H. (2007). Gender differences in smoking behavior among adolescents in Saudi Arabia. Saudi Medical Journal, 28(7), 1102-1108. Alavinia, S.M., Duivenbooden, C. van & Burdorf, A. (2007). Influence of work-related factors and individual characteristics on work ability among Dutch construction workers. Scandinavian Journal of Work Environment & Health, 33(5), 351-357. Assema, P. van, Glanz, K., Martens, M. & Brug, J. (2007). Differences between parents' and adolescents' perceptions of familly food rules and availability. Journal of Nutrition Education and Behavior, 39(2), 84-89. Avendano Pabon, M., Boshuizen, H.C., Schellevis, F.G., Mackenbach, J.P., Lenthe, F.J. van & Bos, G.A.M. van den (2007). Verschillen in preventieve zorg door huisartsen verklaren sociaal-economische verschillen in de incidentie van CVA niet. Huisarts en Wetenschap, 50(5), 86-192.

Beeck, E.F. van, Larsen, CF, Lyons, RA, Meerding, W.J., Mulder, S. & Essink-Bot, M.L. (2007). Guidelines for the conduction of follow-up studies measuring injury-related disability. Journal of Trauma-Injury Infection and Critical Care, 62(2), 534-550. Beirens, T.M.J., Brug, J., Beeck, EE van, Dekker, R., Juttmann, R.E. & Raat, H. (2007). Presence and use of stair gates in homes with toddlers (11-18 months old). Accident Analysis and Prevention, 39(5), 964-968. Bekker- Grob, E.W. de, Polder, J.J., Mackenbach, J.P. & Meerding, W.J. (2007). Towards a comprehensive estimate of national spending on prevention. Bmc Public Health, 7. Bere, E.T. (2007). How to increase school children' intake of fruits and vegetables - experiences from two Norwegian studies. IFAVA Scientific Newsletter, 8, 2. Blankenstein, M. van, Looman, C.W.N., Siersema, P.D., Kuipers, E.J. & Coebergh, J.W.W. (2007). Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003. British Journal of Cancer, 96(11), 1767-1771. Boer, AGEM de, Burdorf, A., Duivenbooden, C. van & Frings-Dresen, M.H.W. (2007). The effect of individual counselling and education on work ability and disability pension: a prospective intervention study in the construction industry. Occupational and Environmental Medicine, 64(12), 792-797. Bogers, R.P., Assema, P. van, Brug, J., Kester, ADM & Dagnelie, P.C. (2007). Psychosocial predictors of increases in fruit and vegetable consumption. American Journal of Health Behavior, 31(2), 135-145. Bos, V., Kunst, A.E., Garssen, J. & Mackenbach, J.P. (2007). Duration of residence was not consistently related to immigrant mortality. Journal of Clinical Epidemiology, 60(6), 585-592. Bourdeaudhuij, I De, Stevens, V, Vandelanotte, C & Brug, J. (2007). Evaluation of an interactive computer-tailored nutrition intervention in a real-life setting. Annals of Behavioral Medicine, 33(1), 39-48. Brenner, H, Coebergh, J.W., Parkin, D.M., Izarzugaza, I, Clavel, J, Arndt, V & Steliarova-Foucher, E (2007). Up-to-date monitoring of childhood cancer long-term survival in Europe: leukaemias and lymphomas. Annals of Oncology, 18(9), 1569-1577. Brewster, DH, Horner, MJD, Rowan, S, Jelfs, P, Vries, E. de & Pukkala, E. (2007). Left-sided excess of invasive cutaneous melanoma in six countries. European Journal of Cancer, 43(18), 2634-2637. Brug, J., Spikmans, F, Aartsen, C, Breedveld, B., Bes, R & Fereira, I (2007). Training dietitians in basic motivational interviewing skills results in changes in their counseling style and in lower saturated fat intakes in their patients. Journal of Nutrition Education and Behavior, 39(1), 8-12. Bruijn, G.J. de, Kremers, S.P.J., Vries, H. de, Mechelen, W. van & Brug, J. (2007). Associations of social-environmental and individual-level factors with adolescent soft drink consumption: results from the SMILE study. Health Education Research, 22(2), 227-237. Burdorf, A., Jarvholm, B & Siesling, S (2007). Asbestos exposure and differences in occurrence of peritoneal mesothelioma between men and women across countries. Occupational and Environmental Medicine, 64(12), 839-842. Burdorf, A. (2007). Economic evaluation in occupational health - its goals, challenges, and opportunities. Scandinavian Journal of Work Environment & Health, 33(3), 161-164. Burdorf, A. (2007). Invited Point of View: The art of conducting workplace intervention studies. International Journal of Industrial Ergonomics, 37(2), 175-176. Burdorf, A., Windhorst, J., Beek, A.J. van der, Molen, H. van der & Swuste, P.H.J.J. (2007). The effects of mechanised equipment on physical load among road workers and floor layers in the construction industry. International Journal of Industrial Ergonomics, 37(2), 133-143. Coebergh, J.W.W. (2007). Epidemiology needs the patients to survive. International Journal of Epidemiology, 36(4), 717719. Coebergh, J.W.W. (2007). Medeleven is ook een kunst. Nederlands Tijdschrift voor Geneeskunde, 151(1), 15-17. Ezendam, N.P.M., Oenema, A., Looij-Jansen, PM van de & Brug, J. (2007). Design and evaluation protocol of "FATaintPHAT", a computer-tailored intervention to prevent excessive weight gain in adolescents. BMC Public Health, 7(1), 324. Federico, B., Costa, G. & Kunst, A.E. (2007). Educational inequalities in initiation, cessation, and prevalence of smoking among 3 Italian birth cohorts. American Journal of Public Health, 97(5), 838-845.

Feleus, A., Bierma-Zeinstra, S.M.A., Miedema, H.S., Verhagen, A.P., Nauta, A.P., Burdorf, A., Verhaar, J.A.N. & Koes, B.W. (2007). Prognostic indicators for non-recovery of non-traumatic complaints at arm, neck and shoulder in general practice-6 months follow-up. Rheumatology, 46(1), 169-176. Ferreira, I, Horst, K van der, Wendel-Vos, W, Kremers, S, Lenthe, F.J. van & Brug, J. (2007). Environmental correlates of physical activity in youth - a review and update. Obesity Reviews, 8(2), 129-154. Geuskens, G.A., Burdorf, A. & Hazes, J.M.W. (2007). Consequences of rheumatoid arthritis for performance of social roles - A literature review. Journal of Rheumatology, 34(6), 1248-1260. Giskes, K., Kampbuis, CBM, Lenthe, F.J. van, Kremers, S, Droomers, M & Brug, J. (2007). A systematic review of associations between environmental factors, energy and fat intakes among adults: is there evidence for environments that encourage obesogenic dietary intakes? Public Health Nutrition, 10(10), 1005-1017. Giskes, K., Kunst, A.E., Ariza, C., Benach, J., Borrell, C., Helmert, U., Judge, K, Lahelma, E., Moussa, K, Ostergren, PO, Patja, K, Platt, S, Prattala, R, Willemsen, MC & Mackenbach, J.P. (2007). Applying an equity lens to tobacco-control policies and their uptake in six western-European countries. Journal of Public Health Policy, 28(2), 261-280. Giskes, K., Lenthe, F.J. van, Brug, J., Mackenbach, J.P. & Turrell, G (2007). Socioeconomic inequalities in food purchasing: The contribution of respondent-perceived and actual (objectively measured) price and availability of foods. Preventive Medicine, 45(1), 41-48. Glymour, MM, Avendano Pabon, M. & Berkman, LF (2007). Is the 'Stroke Belt' worn from childhood? Risk of first stroke and state of residence in childhood and adulthood. Stroke, 38(9), 2415-2421. Griffith, LE, Hogg-Johnson, S, Cole, DC, Krause, N, Hayden, J, Burdorf, A., Leclerc, A, Coggon, D, Bongers, P, Walter, SD & Shannon, HS (2007). Low-back pain definitions in occupational studies were categorized for a meta-analysis using Delphi consensus methods. Journal of Clinical Epidemiology, 60(6), 625-633. Haerens, L, Deforche, B, Maes, L, Brug, J., Vandelanotte, C & Bourdeaudbuij, I De (2007). A computer-tailored dietary fat intake intervention for adolescents: Results of a randomized controlled trial. Annals of Behavioral Medicine, 34(3), 253262. Haerens, L, Bourdeaudhuij, I De, Maes, L, Vereecken, C, Brug, J. & Deforche, B (2007). The effects of a middle-school healthy eating intervention or adolescents' fat and fruit intake and soft drinks consumption. Public Health Nutrition, 10(5), 443-449. Ho, L, Bos, V. & Kunst, A.E. (2007). Differences in cause-of-death patterns between the native Dutch and persons of Indonesian descent in the Netherlands. American Journal of Public Health, 97(9), 1616-1618. Holtslag, HR, Beeck, E.F. van, Lindeman, E & Leenen, L.P.H. (2007). Determinants of long-term functional consequences after major trauma. Journal of Trauma-Injury Infection and Critical Care, 62(4), 919-927. Hooijdonk, C. van, Droomers, M, Loon, JAM van, Lucht, F. & Kunst, A.E. (2007). Exceptions to the rule: Healthy deprived areas and unhealthy wealthy areas. Social Science & Medicine, 64(6), 1326-1342. Horst, K.A. van der, Paw, MJCA, Twisk, J.W.R. & Mechelen, W. van (2007). A brief review on correlates of physical activity and sedentariness in youth. Medicine and Science in Sports and Exercise, 39(8), 1241-1250. Horst, K.A. van der, Oenema, A., Ferreira, I, Wendel-Vos, W, Giskes, K., Lenthe, F. van & Brug, J. (2007). A systematic review of environmental correlates of obesity-related dietary behaviors in youth. Health Education Research, 22(2), 203226. Horst, K.A. van der, Kremers, S, Ferreira, I, Singh, A, Oenema, A. & Brug, J. (2007). Perceived parenting style and practices and the consumption of sugar-sweetened beverages by adolescents. Health Education Research, 22(2), 295304. Houweling, A.J., Ronsmans, C, Campbell, OMR & Kunst, A.E. (2007). Huge poor-rich inequalities in maternity care: an international comparative study of maternity and child care in developing countries. Bulletin of the World Health Organization, 85(10), 745-754. Houweling, A.J., Kunst, A.E., Huisman, M. & Mackenbach, J.P. (2007). Using relative and absolute measures for monitoring health inequalities: experiences from cross-national analyses on maternal and child health. International Journal of Equity in Health, 6(1), 15. Huisman, M., Brug, J. & Mackenbach, J. (2007). Absinthe - is its history relevant for current public health? International Journal of Epidemiology, 36(4), 738-744. Huisman, M. & Mackenbach, J.P. (2007). Intelligentie en de verklaring van sociaaleconomische gezondheidsverschillen. Nederlands Tijdschrift voor Geneeskunde, 151(19), 1059-1061.

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Verhagen, A.P., Schoonloo-Karels, C.H., Bierma-Zeinstra, S.M.A., Feleus, A., Dahaghin, S., Burdorf, A., Vet, H.C.W. de & Koes, B.W. (2007). Ergonomic and physiotherapeutic interventions for treating work-related complaints of the arm, neck or shoulder in adults. A Cochrane Syst Rev. Europa Medicophysica, 43, 391-405.

Verhagen, A.P., Karels, C.H., Bierma-Zeinstra, S.M.A., Feleus, A., Dahaghin, S., Burdorf, A. & Koes, B.W. (2007). Exercise proves effective in a systematic review of work-related complaints of the arm, neck, or shoulder. Journal of Clinical Epidemiology, 60(2), 110-117. Verhoeven, RHA, Coebergh, J.W.W., Kiemeney, L.A.L.M., Koldewijn, E.L. & Houterman, S. (2007). Testicular cancer: Trends in mortality are well explained by changes in treatment and survival in the southern Netherlands since 1970. European Journal of Cancer, 43(17), 2553-2558. Vet, E.W.M.L. de, Nooijer, J. de, Vries, N.K de & Brug, J. (2007). Comparing stage of change and behavioral intention to understand fruit intake. Health Education Research, 22(4), 599-608. Viikari-Juntura, E & Burdorf, A. (2007). Focus and future of occupational health journals. Scandinavian Journal of Work Environment & Health, 33(4), 241-243. Vogel, I., Brug, J., Ploeg, C.P.B. van der & Raat, H. (2007). Young people's exposure to loud music - A summary of the literature. American Journal of Preventive Medicine, 33(2), 124-133. Vries, E. de, Soerjomataram, I., Houterman, S., Louwman, MWJ & Coebergh, J.W.W. (2007). Decreased risk of prostate cancer after skin cancer diagnosis: A protective role of ultraviolet radiation? American Journal of Epidemiology, 165(8), 966-972. Vries, E. de, Houterman, S., Janssen-Heijnen, M.L.G., Nijsten, T., Schans, SAMV de, Eggermont, A.M.M. & Coebergh, J.W.W. (2007). Up-to-date survival estimates and historical trends of cutaneous malignant melanoma in the south-east of The Netherlands. Annals of Oncology, 18(6), 1110-1116. Vries, E. de, Hattem, S. van & Nijsten, T.E.C. (2007). Huidkanker soms fataal, zeker stressvol. Dunne ozonlaag zorgt voor snelle toename. Pharmaceutisch Weekblad, 142, 24-29. Vries, E. de & Rhee, H.J. van der (2007). Zonlicht, vitamine D en kanker. Tijdschrift Kanker, 20, 3. Vries, S.H. de, Postma, R., Raaijmakers, R., Roemeling, S., Otto, S, Koning, H.J. de & Schroder, F.H. (2007). Overall and disease-specific survival of patients with screen-detected prostate cancer in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. European Urology, 51(2), 366-374. Vulto, JCM, Louwman, W.J., Poortmans, P.M.P., Lybeert, LM, Rutten, H.J.T. & Coebergh, J.W.W. (2007). A population based study of radiotherapy in a cohort of patients with breast cancer diagnosed between 1996 and 2000. European Journal of Cancer, 43(13), 1976-1982. Vulto, JCM, Louwman, W.J., Lybeert, M.L.M., Poortmans, P.M.P., Rutten, H.J.T., Brenninkmeijer, SJ & Coebergh, J.W.W. (2007). A population-based study of radiotherapy in a cohort of patients with rectal cancer diagnosed between 1996 and 2000. European Journal of Surgical Oncology, 33(8), 993-997. Wammes, B., Oenema, A. & Brug, J. (2007). The evaluation of a mass media campaign aimed at weight gain prevention among young dutch adults. Obesity, 15(11), 2780-2789. Wammes, B., French, S. & Brug, J. (2007). What young Dutch adults say they do to keep from gaining weight: selfreported prevalence of overeating, compensatory behaviours and specific weight control behaviours. Public Health Nutrition, 10(8), 790-798. Wendel-Vos, W, Droomers, M, Kremers, S, Brug, J. & Lenthe, F. van (2007). Potential environmental determinants of physical activity in adults: a systematic review. Obesity Reviews, 8(5), 425-440. Weyers, S. & Kunst, A.E. (2007). Tackling health inequalities two European projects will identify effective strategies from 2004 to 2007. Sozial-und Präventivmedizin, 51, 257-258. Yanez, AM, Peix, MA, Atserias, N, Arnau, A & Brug, J. (2007). Association of eating attitudes between teenage girls and their parents. International Journal of Social Psychiatry, 53(6), 507-513. Part of book - abstract Brug, J. & Klepp, KI (2007). Children and adolescents. In M. Lawrence & A. Worsley (Eds.), Public helath nutrition: from principles to practice (pp. 5). Sydney: Allen&Unwin. Brug, J. & Wammes, B.M. (2007). Planned promotion of healthy eating to improve population health. In l. Frewer & H. van Trijp (Eds.), Understanding consumers of food products (pp. 571-592). Cambridge: Woodhead Publishing Ltd. Burdorf, A. (2007). Het instrument werkvermogen wetenschappelijk bekeken. In Werkvermogen: verantwoord werken aan duurzame inzetbaarheid (pp. 25-34). Enschede: Gelling Publishing/PreventNed. Elders, L.A.M. (2007). Case: praktijkvoorbeeld uit de eerste lijn. In D Molenaar (Ed.), Werkvermogen: verantwoord werken aan duurzame inzetbaarheid (pp. 141-148). Enschede: Gelling Publishing/PreventNed.

Kunst, A.E. (2007). Socioeconomic inequalities and tobacco. In M. Forrest (Ed.), Why people smoke. Multiple motives approach to tobacco dependence (pp. 85-94). Brussels: European network for Smoking Prevention. Kunst, A.E. & Lenthe, F.J. van (2007). Analyse van volksgezondheid. In J. Brug, P. van Assema & L. Lechner (Eds.), Gezondheidsvoorlichting en gedragsverandering (pp. 33-54). Assen: Koninklijke van Gorcum. Lenthe, F.J. van, Kunst, A.E. & Brug, J. (2007). De analyse van gedrag. In J. Brug, P. van Assema & L. Lechner (Eds.), Gezondheidsvoorlichting en gedragsverandering (pp. 55-73). Assen: Koninklijke van Gorcum. Mackenbach, J.P. & Roskam, A.J.R. (2007). Een raadselachtig verschijnsel. In H. Dagevos & G. Munnichs (Eds.), De obesogne samenleving. Amsterdam: Amsterdam University press. Mackenbach, J.P. & Roskam, A.J.R. (2007). Gewichtige verschillen - over sociale stratificatie en overgewicht. In H. Dagevos & G. Munichs (Eds.), De obesogene samenleving. Amsterdam: University press. Mackenbach, J.P. & Roskam, A.J.R. (2007). Gewichtige verschillen: sociale stratificatie en overgewicht. In H. Dagevos & G. Munichs (Eds.), De obesogne samenleving (pp. 33 42). Amsterdam: Amsterdam University press. Book editorship Mackenbach, J.P., Meerding, W.J. & Kunst, A.E. (Eds.). (2007). Economic implications of socio-economic inequalities in health in the European Union. Luxembourg: European Communities, Health & Consumer Protection. Plochg, T., Klazinga, N.S. & Mackenbach, J.P. (Eds.). (2007). Handboek Gezondheidszorgonderzoek. Houten: Bohn Stafleu van Loghum. Internal report Hoeven, T & Beeck, E.F. van (2007). Onderzoek WIP-reichtlijnen. public health. Hoeven, T. van der & Beeck, E.F. van (2007). Onderzoek WIP-richtlijnen 2007. public health. Kunst, A.E., Meerding, W.J., Varenik, N., Polder, J.J. & Mackenbach, J.P. (2007). Sociale verschillen in zorggebruik en zorgkosten in Nederland 2003. Zorg voor euro's. public health. Mackenbach, J.P., Kunst, A.E., Stirbu, I., Roskam, A.J.R. & Schaap, M.M. (2007). Tackling health inequalities in Europe: an integrated approach. EUROTHINE final report. public health. Mackenbach, J.P. (2007). Brother wind, sister water. public health on a finite earth. public health. Mackenbach, J.P., Vlas, S.J. de & Beaufort, I.D. de (2007). Water: source of health and disease. public health. Voordracht - Lezing Mackenbach, J.P. (2007, september 28). Gezondheid en ziekte in een ongelijke wereld: sociale feiten, biologische uitkomsten. Rotterdam, Lof der Geneeskunde; ErasmusMC-lezing over medische wetenschap en mensen.

EMC NIHES-02-67-01 - Clinical research in general practice. Programme design in brief The aim of research activities of the Department of General Practice is to do research of academic quality, based on and derived from issues in general practice, aimed at the enhancement of the quality of general practice and supporting the academic workplace of general practice.The research encompasses the scientific basis and quality improvement of general practice. The most important components are the following:1) Clinical research of the effects of preventive, diagnostic, and therapeutic strategies in general practice by clinical epidemiologic studies and randomised trials. The results of such studies will be used in decision analysis and guideline development. (In short "what should general practitioners do?").2) Health services research in general practice. We evaluate interventions aimed at changes in general practice. These changes consider the quality of care, relationship with specialists, computerisation, and personal aspects of care. (In short "how do general practitioners practice and how can they improve?").Within this research programme patient-centered studies in the field of musculoskeletal disorders and diseases in childhood dominate. In view of the comprehensive approach of general practice other fields are addressed as well.In 2000 the chair of intellectual disability medicine has been installed (Prof Evenhuis), with as main research themes 'sensory impairment' and 'comorbidity in children with severe cerebral palsy'. Key figures Department

SP1

SP2

SP3

SP4

SPtot

family practice

8,81

5,01

0

2,13

15,95

Total

8,81

5,01

0

2,13

15,95

T1

T2

4

T3

0

Ttot

0

IS

4

FS

56

OP

13

Ptot

70

143

Theses Boks, S.S. (2007, maart 21). MRI Imaging in patients with knee injury: an observational study in general practice. EUR (139 pag.). Prom./coprom.: Prof.Dr. M.G.M. Hunink, Dr. S.M.A. Bierma-Zeinstra & Drs. D. Vroegindeweij. Faber, E. (2007, januari 18). Management of sick leave due to musculoskeletal disorders. EUR (147 pag.). Prom./coprom.: Prof.Dr. B.W. Koes & Prof.Dr. J.A.N. Verhaar. Huisstede, B.M.A. (2007, juni 08). Complaints of the Arm, Neck and/or Shoulder. A new approach to its terminology and classification the CANS model. EUR (159 pag.). Prom./coprom.: Prof.Dr. B.W. Koes & Prof.Dr. J.A.N. Verhaar. Mohammedamin, S.A. (2007, februari 14). Infectious skin diseases in children in general practice. Epidemiology and management. EUR (123 pag.). Prom./coprom.: Prof.Dr. B.W. Koes, F.G. Schellevis & Dr. J.C. van der Wouden. Article/Letter to the editor Akkermans, S.M.A., Vermaas, I., Vonk, F., Verkerk, K. & Verhagen, A.P. (2007). Validering van de Nederlandse versie van de Pain Stages of Change Questionnaire (PSOCQ-NL). Nederlands Tijdschrift voor Fysiotherapie, 117, 147-154. Bakker, E.W.P., Verhagen, A.P., Lucas, C, Koning, H.J.C.M.F., Haan, R.J. de & Koes, B.W. (2007). Daily spinal mechanical loading as a risk factor for acute non-specific low back pain: a case-control study using the 24-Hour Schedule. European Spine Journal, 16(1), 107-113. Bakker, E.W.P., Verhagen, A.P., Lucas, C, Koning, H.J.C.M.F. & Koes, B.W. (2007). Spinal mechanical load: a predictor of persistent low back pain? A prospective cohort study. European Spine Journal, 16(7), 933-941. Balen, J. van, Verduijn, M.M., Sachs, A.P.E., Berger, M.Y., Lucassen, P.L.B.J., Wierdsma, T.J. & Goudswaard, A.N. (2007). Samenvatting van de standaard `Allergische en niet-allergische rhinitis (eerste herziening) van het Nederlands Huisartsen Genootschap. Nederlands Tijdschrift voor Geneeskunde, 151, 2261-2265. Bareman, F.P., Eusman, J.P. & Thomas, S. (2007). Ingezonden: Restlesslegssyndroom. Huisarts en Wetenschap, 7, 331332. Belo, J.N. & Thomas, S. (2007). De Standaard `Pelvic inflammatory disease (eerste herziening) van het Nederlands Huisartsen Genootschap; reactie vanuit de huisartsgeneeskunde. Nederlands Tijdschrift voor Geneeskunde, 151, 730731. Belo, J.N., Berger, M.Y., Reijman, M., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2007). Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies. Arthritis & Rheumatism, 57(1), 13-26. Berger, M.Y., Gieteling, M.J. & Benninga, M.A. (2007). Chronic abdominal pain in children. British Medical Journal (International Edition), 334(7601), 997-1002. Bernsen, R.M.D. & Wouden, J.C. van der (2007). Complications at birth and subsequent wheeze: Risk of attrition bias. American Journal of Respiratory and Critical Care Medicine, 175(8), 859-859.

Bierma-Zeinstra, S.M.A. & Koes, B.W. (2007). Risk factors and prognostic factors of hip and knee osteoarthritis. Nature Clinical Practice Rheumatology, 3(2), 78-85. Blanker, M.H. (2007). Re: Erectile dysfunction - An observable marker of diabetes mellitus? A large national epidemiological study - P. Sun, A. Cameron, A. Seftel, R. Shabsigh, C. Niederberger and A. Guay - J Urol 2006; 176 : 1081-1085. Journal of Urology, 177(4), 1588-1588. Bohnen, A.M., Groeneveld, F.P. & Bosch, J.L.H.R. (2007). Serum prostate-specific antigen as a predictor of prostate volume in the community: The krimpen study. European Urology, 51(6), 1645-1653. Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M. & Bierma-Zeinstra, S.M.A. (2007). Clinical consequences of posttraumatic bone bruise in the knee. American Journal of Sports Medicine, 35(6), 990-995. Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M.G.M. & Bierma-Zeinstra, S.M.A. (2007). MRI follow-up of posttraumatic bone bruises of the knee in general practice. American Journal of Roentgenology, 189(3), 556562. Boks, S.S. & Bierma-Zeinstra, S.M.A. (2007). Response (6). Radiology, 243(1). Boluyt, N., Bueving, H.J., Looymans- van den Akker, I. & Wouden, J.C. van der (2007). Griepvaccinatie bij kinderen met astma. Praktische Pediatrie, 2, 57-61. Bosch, J.L.H.R., Tilling, K, Bohnen, A.M., Bangma, C.H. & Donovan, J.L. (2007). Establishing normal reference ranges for prostate volume change with age in the population-based krimpen-study: Prediction of future prostate volume in individual men. Prostate, 67(16), 1816-1824. Bot, C.M.A. de & Moed, H. (2007). Quantitative assessment of the compliance with once-daily sublingual immunotherapy in children. Pediatric Allergy and Immunology, 18(7), 627-627. Brinks, A., Rijn, R.M. van, Bohnen, A.M., Slee, G.L.J., Verhaar, J.A.N., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2007). Effect of corticosteroid injection for trochanter pain syndrome: design of a randomised clinical trial in general practice. BioMed Central, 8. Brinks, A. (2007). Het ondraaglijke meetbaar maken. Huisarts en Wetenschap, 12, 19-21. Brouwer, GM, Tol, AW van, Bergink, A.P., Belo, J.N., Bernsen, R.M.D., Reijman, M., Pols, H.A.P. & Bierma-Zeinstra, S.M.A. (2007). Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis & Rheumatism, 56(4), 1204-1211. Brouwer, R.W., Raaij, VTM, Bierma-Zeinstra, S.M.A., Verhagen, A.P., Jakma, T.S.C. & Verhaar, J.A.N. (2007). Osteotomy for treating knee osteoarthritis (Withdrawn Paper. 2007, art. no. CD004019). Cochrane Database Systems Review. Bueving, H.J., Thomas, S., Jongste, J.C. de & Wouden, J.C. van der (2007). Nieuwe doelgroepen voor influenzavaccinatie; advies van de Gezondheidsraad. Nederlands Tijdschrift voor Geneeskunde, 151(49), 2749-2749. Bueving, H.J. & Wouden, J.C. van der (2007). What is the role of virus vaccination in patients with asthma? Current Allergy & Asthma Reports, 7(1), 72-76. Bueving, H.J. & Wouden, J.C. van der (2007). Moeten kinderen met astma ingeënt worden tegen griep? Bijblijven. Cumulatief Geneeskundig Nascholingssysteem, 23, 43-49. Bueving, H.J. & Wouden, J.C. van der (2007). Moeten kinderen met astma worden ingeënt tegen griep? Het non-effect van de griepprik. Bijblijven. Cumulatief Geneeskundig Nascholingssysteem, 10, 43-51. Calis, E.A.C., Olieman, J.F., Rieken, R. & Penning, C. (2007). Impact of malnutrition on gastrointestinal disorders and gross motor abilities in children with cerebral palsy. Brain & Development, 29, 534. Dahaghin, S., Bierma-Zeinstra, S.M.A., Koes, B.W., Hazes, J.M.W. & Pols, H.A.P. (2007). Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Annals of the Rheumatic Diseases, 66(7), 916-920. Eusman, J.P. (2007). Addendum bij NHG-Standaard TIA. Huisarts en Wetenschap, 50, 123. Evenhuis, H., Graaf, G. van de, Walinga, M.J., Heus, G.C.B. de, Genderen, M.E. van, Verhoeff, M., Lantau, V.K., MeulenEnnema, H. van der, Meester, N., Wienen, L. & Schalij-Delfos, N. (2007). Detection of childhood visual impairment in atrisk groups. Journal of Policy and Practice in Intellectual Disabilities, 4(3), 165-169. Ewals, F.V.P.M. (2007). Dieet bij PKU. Tijdschrift voor Artsen voor Verstandelijk Gehandicapten, 25, 52.

Feleus, A., Bierma-Zeinstra, S.M.A., Miedema, H.S., Verhagen, A.P., Nauta, A.P., Burdorf, A., Verhaar, J.A.N. & Koes, B.W. (2007). Prognostic indicators for non-recovery of non-traumatic complaints at arm, neck and shoulder in general practice-6 months follow-up. Rheumatology, 46(1), 169-176. Gan, M, Smit, M., Dohle, G.R., Bosch, J.L.H.R. & Bohnen, A. (2007). Determinants of ejaculatory dysfunction in a community-based longitudinal study. Bju International, 99(6), 1443-1448. Gent, RN van, Siem, D, Middelkoop, M. van, Os, A.G. van, Bierma-Zeinstra, S.M.A., Koes, B.W. & Taunton, JE (2007). Incidence and determinants of lower extremity running injuries in long distance runners: a systematic review. British Journal of Sports Medicine, 41(8), 469-480. Gent, RN van, Siem, D, Middelkoop, M. van, Os, A.G. van, Bierma-Zeinstra, S.M.A. & Koes, B.W. (2007). Incidence and determinans of lower extremity running injuries in long distance runners: a systmatic review. Geneeskunde en Sport, 4, 16-29. Groot, H. de, Brand, P.L.P., Fokkens, WF & Berger, M.Y. (2007). Allergic rhinoconjunctivitis in children. British Medical Journal (International Edition), 335(7627), 985-988. Groot, I.B. de, Reijman, M., Terwee, C.B., Bierma-Zeinstra, S.M.A., Favejee, M, Roos, EM & Verhaar, J.A.N. (2007). Validation of the Dutch version of the Hip Disability and Osteoarthritis Outcome Score. Osteoarthritis and Cartilage, 15(1), 104-109. Harmsen, M., Wensing, M., Braspenning, J.C.C., Wolters, RJ, Wouden, J.C. van der & Grol, R.P.T.M. (2007). Management of children's urinary tract infections in Dutch family practice: a cohort study. BMC Family Practice, 8. Harmsen, M., Wensing, M., Wouden, J.C. van der & Grol, R.P.T.M. (2007). Parents' awareness of and knowledge about young children's urinary tract infections. Patient Education and Counseling, 66(2), 250-255. Huisstede, B.M.A., Miedema, H.S., Verhagen, A.P., Koes, B.W. & Verhaar, J.A.N. (2007). Multidisciplinary consensus on the terminology and classification of complaints of the arm, neck and/or shoulder. Occupational and Environmental Medicine, 64(5), 313-319. Karels, C.H., Bierma-Zeinstra, S.M.A., Burdorf, A., Verhagen, A.P., Nauta, A.P. & Koes, B.W. (2007). Social and psychological factors influenced the course of arm, neck and shoulder complaints. Journal of Clinical Epidemiology, 60(8), 839-848. Koes, B.W., Tulder, M.W. van & Peul, W.C. (2007). Diagnosis and treatment of sciatica. British Medical Journal (International Edition), 334(7607), 1313-1317. Koes, B.W. (2007). Evidence-based management of acute low back pain. Lancet (UK), 370(9599), 1595-1596. Kok, E.T., Groeneveld, F.P.M.J., Busschbach, J.J.V. van, Hop, W.C.J., Bosch, J.L.H.R., Thomas, S. & Bohnen, A.M. (2007). Influence of coping styles on quality of life in men with new and increasing lower urinary tract symptoms. Urologia Internationalis, 79(3), 226-230. Koning, S. (2007). De standaard 'Constitutioneel eczeem' (eerste herziening) van het Nederlands Huisartsen Genootschap; reactie vanuit de huisartsgeneeskunde. Nederlands Tijdschrift voor Geneeskunde, 151, 1385-1386. Laan, J van der & Walma, E.P. (2007). Onvoldoende bewijs voor thiazolidinederivaten bij diabetes mellitus. Huisarts en Wetenschap, 50, 116-117. Lievense, A.M., Koes, B.W., Verhaar, J.A.N., Bohnen, A.M. & Bierma-Zeinstra, S.M.A. (2007). Prognosis of hip pain in general practice: A prospective followup study. Arthritis & Rheumatism, 57(8), 1368-1374. Luijsterburg, P.A.J., Lamers, L.M., Verhagen, A.P., Ostelo, R.W.J.G., Hoogen, H.J.M.M. van den, Peul, W.C., Avezaat, C.J.J. & Koes, B.W. (2007). Cost-effectiveness of physical therapy and general practitioner care for sciatica. Spine, 32(18), 1942-1948. Luijsterburg, P.A.J., Verhagen, A.P., Ostelo, R.W.J.G., Os, TAG van, Peul, W.C. & Koes, B.W. (2007). Effectiveness of conservative treatments for the lumbosacral radicular syndrome: a systematic review. European Spine Journal, 16(7), 881-899. Mensch, S.M. & Penning, C. (2007). Hands on video observatie bij de beoordeling van motorische vaardigheden van kinderen met EMCB. Nederlands Tijdschrift voor Kinderfysiotherapie, 19, 19-23. Meuwese-Jongejeugd, A., Verschuure, H. & Evenhuis, H.M. (2007). Hearing aids: expectations and satisfaction of people with an intellectual disability, a descriptive pilot study. Journal of Intellectual Disability Research, 51, 913-922. Middelkoop, M. van, Kolkman, J., Ochten, J van, Bierma-Zeinstra, S.M.A. & Koes, B.W. (2007). Course and predicting factors of lower-extremity injuries after running a marathon. Clinical Journal of Sport Medicine, 17(1), 25-30.

Moed, H. (2007). Is het voor de huisarts veilig sublinguale immunotherapie voor te schrijven? Ned. Tijdschrift voor Allergie, 2, 90-91. Mohammedamin, S.A., Wouden, J.C. van der, Koning, S., Schellevis, F.G., Suijlekom-Smit, L.W.A. van & Koes, B.W. (2007). Reported incidence and treatment of dermatophytosis in children in general practice: a comparison between 1987 and 2001. Mycopathologia, 164(6), 271-278. Montenij, M., Niesters, H.G.M., Moll, H.A. & Berger, M.Y. (2007). Human bocavirus in febrile children, the netherlands. Emerging Infectious Diseases, 13(1), 180-182. Nieuwenhuis, MH, Röst, C.C.M. & Verhagen, A.P. (2007). Bekkenpijn rond de zwangerschap; een descriptieve studie. Nederlands Tijdschrift voor Fysiotherapie, 117, 23-26. Peul, W.C., Houwelingen, H.C. van, Hout, W.B. van den, Brand, R., Eekhof, JAH, Tans, JTJ, Thomeer, RTWM & Koes, B.W. (2007). Surgery versus prolonged conservative treatment for sciatica. New England Journal of Medicine, 356(22), 2245-2256. Peul, W.C., Houwelingen, H.C. van, Hout, W.B. van den, Brand, R., Eekhof, JAH, Tans, J.Th.J., Thomeer, RTWM & Koes, B.W. (2007). Vroeg opereren of langer afwachten voor het lumbosacraal radiculair syndroom: een gerandomiseerd onderzoek. Nederlands Tijdschrift voor Geneeskunde, 151, 2512-2523. Pillay, J., Wouden, J.C. van der & Leenen, L.P.H. (2007). De presentatie-indicator `heupfractuur: opereren binnen 24 uur retrospectief toegepast bij 217 pati쬫nten in het Universitair Medisch Centrum Utrecht, 2000-2003: postoperatief minder vaak pneumonie, maar niet minder sterfte. Nederlands Tijdschrift voor Geneeskunde, 151, 967-970. Pleumeekers, H.J.C.M. (2007). Rol van Geneeskunde, 151, 1957.

alarmsymptomen

bij diagnose van kanker. Nederlands Tijdschrift voor

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Uijen, J.H.J.M. (2007). Fraaie astmatrials wringen met dagelijkse praktijk. Huisarts en Wetenschap, 50, 235. Uijen, J.H.J.M. (2007). Huisartsen blijven op de kleintjes letten. Huisarts en Wetenschap, 50, 131. Uitterlinden, E.J., Jahr, H., Koevoet, J.L.M., Bierma-Zeinstra, S.M.A., Verhaar, J.A.N., Weinans, H. & Osch, G.J.V.M. van (2007). Glucosamine reduces anabolic as well as catabolic processes in bovine chondrocytes cultured in alginate. Osteoarthritis and Cartilage, 15(11), 1267-1274. Vaal, J., Gussekloo, J, Klerk, M.M.Y. de, Frijters, D.H.M., Evenhuis, H.M., Beek, A.P. van, Nispen, R.M. van, Smits, C.G.C. & Deeg, D.J. (2007). Combined vision and hearing impairment: in an estimated 30,000-35,000 people aged 55 years or over in The Netherlands. Nederlands Tijdschrift voor Geneeskunde, 151, 1459-1463. Veerman, S. & Ewals, F.V.P.M. (2007). Sterven en rouw in de instutionele zorg voor verstandelijk gehandicapten. Tijdschrift voor Artsen voor Verstandelijk Gehandicapten, 25, 70-74. Verhagen, A.P., Bierma-Zeinstra, S.M.A., Boers, M., Cardoso, J.R., Lambeck, J, Bie, R.A. de & H, CW de Vet (2007). Balneotherapy for osteoarthritis. Cochrane Database Systems Review. Verhagen, A.P., Scholten-Peeters, GGGM, Wijngaarden, S. van, Bie, R.A. de & Bierma-Zeinstra, S.M.A. (2007). Conservative treatments for whiplash. Cochrane Database Systems Review. Verhagen, A.P. (2007). Effect of bracing and other conservative interventions in the treatment of idiopathic scoliosis in adolescents: a systematic review of clinical trials. (author response). Physical Therapy, 87, 112-113. Verhagen, A.P., Schoonloo-Karels, C.H., Bierma-Zeinstra, S.M.A., Feleus, A., Dahaghin, S., Burdorf, A., Vet, H.C.W. de & Koes, B.W. (2007). Ergonomic and physiotherapeutic interventions for treating work-related complaints of the arm, neck or shoulder in adults. A Cochrane Syst Rev. Europa Medicophysica, 43, 391-405. Verhagen, A.P., Karels, C.H., Bierma-Zeinstra, S.M.A., Feleus, A., Dahaghin, S., Burdorf, A. & Koes, B.W. (2007). Exercise proves effective in a systematic review of work-related complaints of the arm, neck, or shoulder. Journal of Clinical Epidemiology, 60(2), 110-117. Vos, C. de, Verhagen, A., Passchier, J. & Koes, B. (2007). Management of acute neck pain in general practice: a prospective study. British Journal of General Practice, 57(534), 23-28. Vrielink, G.J. (2007). Leef gezond! (Book review). Huisarts en Wetenschap, 50, 570. Walma, E.P. (2007). Voorschrijfgedrag onder de loep. Book review: Jacoba Greving. Trends in cardiovascular drug prescription in Dutch general practice: role of patient and physician related characteristics. Proefschrift, Groningen 2007. Huisarts en Wetenschap, 50, 338-339. Wielink, G., Koning, S., Oosterhout, R.M., Wetzels, R., Nijman, F.C. & Draijer, L.W. (2007). NHG-Standaard bacteri쬫le huidinfecties. Huisarts en Wetenschap, 50, 426-444. Wierdsma, T.J., Walma, E.P., Thomas, S. & Stalman, W.A.B. (2007). Arts moet statines kiezen. Medisch Contact, 23, 1011. Willemse - van Son, A.H.P., Ribbers, G.M., Verhagen, A.P. & Stam, H.J. (2007). Prognostic factors of long-term functioning and productivity after traumatic brain injury: a systematic review of prospective cohort studies. Clinical Rehabilitation, 21(11), 1024-1037. Wouden, J.C. van der & Verhagen, A.P. (2007). Breathing techniques in the management of asthma. Thorax, 62(9), 834834. Wouden, J.C. van der & Bernsen, R.M.D. (2007). Neonatal BCG vaccination protective for wheeze: Residual confounding? Journal of Allergy and Clinical Immunology, 120(5), 1226-1226. Wouden, J.C. van der, Blankenstein, AH, Huibers, MJH, Windt, D.A.W.M., Stalman, W.A.B. & Verhagen, A.P. (2007). Survey among 78 studies showed that Lasagna's law holds in Dutch primary care research. Journal of Clinical Epidemiology, 60(8), 819-824. Wouden, J.C. van der (2007). Arts-patiëntcommunicatie op de poli. Huisarts en Wetenschap, 50, 131. Wouden, J.C. van der (2007). Bewegen, bewegen, bewegen. Huisarts en Wetenschap, 50, 521. Wouden, J.C. van der (2007). Bewegen, bewegen, bewegen. Kleutersmaak. Tijdschrift voor praktijkondersteuning, 1, 149.

Wouden, J.C. van der, Blankenstein, AH, Huibers, M., Windt, D.A.W.M., Stalman, W.A.B. & Verhagen, A.P. (2007). De wet van Lasagna. Problemen bij het werven van patiënten voor onderzoek in de huisartsenpraktijk. Huisarts en Wetenschap, 50, 650-655. Wouden, J.C. van der (2007). Diensten verkopen. Huisarts en Wetenschap, 50, 37. Wouden, J.C. van der (2007). Doping onder recreatieve sporters. Huisarts en Wetenschap, 50, 286. Wouden, J.C. van der (2007). Geruststellen beter voor het onderzoek? Huisarts en Wetenschap, 50, 342. Wouden, J.C. van der (2007). Het beste bewijs. Tijdschrift voor praktijkondersteuning, 1, 99-100. Wouden, J.C. van der (2007). Het zit in de familie. Tijdschrift voor praktijkondersteuning, 1, 8. Wouden, J.C. van der (2007). Het zit in de familie. Huisarts en Wetenschap, 50, 39. Wouden, J.C. van der (2007). Hoe meer hoe leuker. Huisarts en Wetenschap, 50, 236. Wouden, J.C. van der (2007). Hoeveel statinegebruikers stopte Radar? Tijdschrift voor praktijkondersteuning, 1, 179. Wouden, J.C. van der (2007). Hoeveel statinegebruikers stopte Radar? . Huisarts en Wetenschap, 50, 575. Wouden, J.C. van der (2007). Jongeren met overgewicht op kamp. Huisarts en Wetenschap, 50, 236. Wouden, J.C. van der (2007). Kleutersmaak. Tijdschrift voor praktijkondersteuning, 1, 147. Wouden, J.C. van der (2007). Kleutersmaak.. Huisarts en Wetenschap, 50, 522. Wouden, J.C. van der (2007). Medisch zoeken. Tijdschrift voor praktijkondersteuning, 1, 173. Wouden, J.C. van der (2007). Nabestaanden van su cideslachtoffers. Huisarts en Wetenschap, 50, 285. Wouden, J.C. van der (2007). Nog meer diensten verkopen. Huisarts en Wetenschap, 50, 129. Wouden, J.C. van der (2007). NS3. Huisarts en Wetenschap, 50, 573. Wouden, J.C. van der (2007). Of toch maar geen griepprik? Huisarts en Wetenschap, 50, 39. Wouden, J.C. van der (2007). Reddingswerkers: hoe gaat het na de ramp? Huisarts en Wetenschap, 50, 341. Wouden, J.C. van der (2007). Transcendente meditatie goed voor het hart? Huisarts en Wetenschap, 50, 184. Wouden, J.C. van der (2007). Vergeet de provinciale weg niet. Huisarts en Wetenschap, 50, 132. Wouden, J.C. van der (2007). Verkeerslawaai en slaap. Huisarts en Wetenschap, 50, 287. Wouden, J.C. van der (2007). Wie is er nog niet geautomatiseerd? Huisarts en Wetenschap, 50, 83. Wouden, J.C. van der (2007). Ziekte meten in de Engelse huisartsenpraktijk: meten met verschillende maten. Huisarts en Wetenschap, 50, 184. Part of book - abstract Berger, M.Y. & Benninga, M.A. (2007). Plotselinge buikpijn bij kinderen. In J.W.M. Muris, E.M.H. Mathus-Vliegen & Th.B. Voorn (Eds.), Praktische huisartsgeneeskunde: Gastroenterologie. Houten: Bohn Stafleu van Loghum. Blanker, M.H. (2007). Balanitis. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Bohnen, A.M. (2007). Retropatellaire chondropathie / chondropathia patellae. In Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Boukes, F.S. & Walma, E.P. (2007). Neusbloeding / epistaxis. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Ponsioen, B.P. (2007). Luis/pediculosis. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Ponsioen, B.P. (2007). Netelroos/urticaria. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier.

Teunissen, H. (2007). Bellse parese. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Tulder, M.W. van & Koes, B.W. (2007). Evidence based medicine for acute and chronic low back pain: guidelines. In Vleeming & M. Stoeckart (Eds.), Movement, stability & Lumbopelvic Pain. Edinburgh: Churchill Livingstone. Tulder, M.W. van, Koes, B.W. & Bombardier, C. (2007). Low back pain. In H. Breivik & M. Shipley (Eds.), Pain, Best practice & research compendium. Edinburgh: Elsevier. Walma, E.P. (2007). Chronisch hartfalen. Therapie in de eerste lijn. In J.N. Keeman, P.W.E. de Leeuw, J.A. Mazel & F.G. Zitman (Eds.), Jaarboek huisartsgeneeskunde. Houten: Bohn Stafleu van Loghum. Walma, E.P. (2007). Heesheid/dysfonie. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Walma, E.P. (2007). Orthostatische hypotensie. In J.A.H. Eekhof, A. Knuistingh Neven & W. Opstelten (Eds.), Kleine kwalen in de huisartsenpraktijk. Amsterdam: Elsevier. Windt, D. van der & Koes, B.W. (2007). Are corticosteroid injections as effective as physiotherapy for treatment of the painful shoulder? In D MacAuly & T Best (Eds.), Evidence-based Sports Medicine. Malden: Blackwell publishing. Wouden, J.C. van der & Otters, J.B.M. (2007). Epidemiologie. In P.J.E. Bindels & C.M.F. Kneepkens (Eds.), Kindergeneeskunde, in serie Praktische Huisartsgeneeskunde. Houten: Bohn Stafleu van Loghum. Book editorship Faddegon, H.C. (Ed.). (2007). Man schietop! Ouders draaien de rollen om. Utrecht: Goplier. Meer, L.W. van der, Poel, B.N.M. van der, Vries, A.D. de & Weber, R.F.A. (Eds.). (2007). Ontwikkelingen in de Geneeskunde 2007. Rotterdam: ErasmusMC. Walma, E.P. & Loenen, A.C.D. van (Eds.). (2007). Farmacotherapeutisch Kompas. Diemen: CVZ.

EMC NIHES-03-30-01 - Implementation of diagnostic and interventional imaging technology Programme design in brief The research program focuses on the implementation of new techniques used for diagnostic and interventional imaging technology. Specific topics of interest within the program are Magnetic Resonance (MR) technology (including interventional MRI), Multidetector Spiral Computed Tomography (MSCT), and interventional radiology. Projects involve high-speed MR-angiography of coronary/carotid arteries and veins, MRI of organ perfusion (e.g. brain perfusion in stroke, perfusion in transplant organs), real-time imaging of catheter and needle manipulations, MRI-temperature mapping (to monitor thermo-ablative treatment of localized heat-induced gene therapy), and percutaneous treatment of vascular disease. Emphasis is placed on carotid artery stenting, percutaneous treatment of aortic aneurysmal disease in elective and acute situations, creation of Transjugular Intrahepatic Portosystemic Shunts (TIPS), thermo-ablation with laser or focused percutaneous ultrasound, and non-invasive coronary angiography with MSCT. A parallel line of investigation implements molecular imaging techniques developed in EMC NIHES-03-30-03. Although we principally use MRI (3T) imaging techniques, the potential exists to use MSCT for molecular imaging for projects for which this would be advantageous. Possible future directions include quantification of tumor perfusion and angiogenesis, heatinduced local drug delivery or gene therapy, and/or applying heat- sensitive contrast agents. There is extensive collaboration with clinical groups within Erasmus MC - including the Departments of Internal Medicine, Pediatrics, Vascular Surgery, Cardiology, Neurology, and Surgical Oncology - and with Erasmus MC basic science groups - including the Department of Experimental Cardiology/Thorax Center and the Department of Medical Informatics Key figures Department

SP1

SP2

SP3

SP4

SPtot

cardiology

0,16

0

0

0

0,16

epidemiology & biostatics

1,75

0

0

0

1,75

pediatrics

0,03

0

0

0

0,03

radiology

6,15

0,1

0

0

6,25

Total

8,09

0,1

0

0

8,19

T1

T2

4

T3

1

Ttot

0

IS

5

FS

45

12

OP

Ptot

13

Theses Berg, W.J.B.W. van den (2007, februari 07). Functional cardiovascular assessment in congenital heart disease. EUR (223 pag.). Prom./coprom.: Prof.Dr. W.A. Helbing & Prof.Dr. P.M.T. Pattynama. Bos, I.C. van den (2007, mei 16). State-of-the-art magnetic resonance imaging in the work-up of primary hepatocellular tumors. EUR (175 pag.). Prom./coprom.: S.M. Hussain, Prof.Dr. G.P. Krestin & R.A. de Man. Kock, M.C.J.M. (2007, januari 24). Diagnostic imaging of peripheral arterial disease with multi-detector row computed tomography angiography. EUR. Prom./coprom.: Prof.Dr. M.G.M. Hunink & Prof.Dr. P.M.T. Pattynama. Odink, A.E. (2007, januari 17). Epidemiologic studies on arterial calcification: The Rotterdam Study. EUR (131 pag.). Prom./coprom.: Prof.Dr. A. Hofman, Prof.Dr. G.P. Krestin, Dr. J.C.M. Witteman & A. van der Lugt. Wang, L. (2007, mei 09). Magnetic resonance imaging of the prostate. EUR (216 pag.). Prom./coprom.: Prof.Dr. G.P. Krestin & H. Hricak. Article/Letter to the editor Bartolotta, TV, Midiri, M., Rollandi, G.A., Cademartiri, F., Lagalla, R & Cardinale, AE (2007). Characterization of benign hepatic tumors arising in fatty liver with SonoVue and pulse interversion US. Abdominal Imaging, 32, 84-91. Berg, W.J.B.W. van den, Hop, W.C.J., Strengers, J.L.M., Jongste, J.C. de, Osch-Gevers, M. van, Meijboom, F.J., Pattynama, P.M.T., Bogers, A.J.J.C. & Helbing, W.A. (2007). Clinical condition at mid-to-late follow-up after transatrial repair of tetralogy of Fallot. Journal of Thoracic and Cardiovascular Surgery, 133, 470-477. Berg, W.J.B.W. van den, Wielopolski, P.A., Meijboom, F.J., Witsenburg, M., Bogers, A.J.J.C., Pattynama, P.M.T. & Helbing, W.A. (2007). Diastolic function in repaired Tetralogy of Fallot at rest and during stress: assessment with mrimaging. Radiology, 243(1), 212-219. Bos, I.C. van den, Hussain, S.M., Dwarkasing, R.S., Hop, W.C.J., Zondervan, P.E., Man, R.A. de, Ijzermans, J.N.M., Walker, CW & Krestin, G.P. (2007). MR Imaging of hepatocellular carcinoma: Relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. Jmri-Journal of Magnetic Resonance Imaging, 26(6), 1548-1555. Cademartiri, F., Malago, R., Grutta, L. la, Alberghina, F., Palumbo, A., Maffei, E., Brambilla, V., Pugliese, F., Runza, G., Midiri, M., Mollet, N.R. & Krestin, G.P. (2007). Coronary variants and anomalies: methodology of visualisation with 64-slice CT and prevalence in 202 consecutive patients. Radiologia Medica, 112(8), 1117-1131.

75

Cademartiri, F., Maffei, E., Palumbo, A., Mollet, N.R., Lugt, A. van der & Crisi, G (2007). Visual claudicatio: diagnosis with 64-slice computed tomography. International Journal of Cardiovascular Imaging, 23(3), 393-396. Dudink, J., Lequin, M.H., Pul, C. van, Buijs, J., Conneman, H.N.L., Goudoever, J.B. van & Govaert, P. (2007). Fractional anisotropy in white matter tracts of very-low-birth -weight infants. Pediatric Radiology, 37(12), 1216-1223. Feringa, H.H.H., Hendriks, J.M., Karagiannis, S.E., Schouten, O., Vidakovic, R., Sambeek, M.R.H.M. van, Klein, J. de, Noordzij, P.G., Bax, J.J. & Poldermans, D. (2007). Carotid artery stenting versus endarterectomy in relation to perioperative myocardial ischemia, troponin T release and major cardiac events. Coronary Artery Disease, 18(6), 483487. Flach, H.Z., Ouhlous, M., Hendriks, J.M., Sambeek, M.R.H.M. van, Veenland, J.F., Dijk, L.C. van & Lugt, A. van der (2007). Diffusion-weighted imaging to compare different cerebral protection devices in carotid artery stenting. EuroIntervention, 3, 243-248. Geenen, R.W.F., Hussain, S.M., Siersema, P.D., Poley, J.W., Kuipers, E.J. & Krestin, G.P. (2007). Current status of MRI in patients with inflammatory bowel disease colitis. Applied Radiology, 36(2), 10-22. Groen, H.C., Gijsen, F.J.H., Lugt, A. van der, Ferguson, MS, Hatsukami, TS, Steen, A.F.W. van der, Yuan, C. & Wentzel, J.J. (2007). Plaque rupture in the carotid artery is localized at the high shear stress region - A case report. Stroke, 38(8), 2379-2381. Heijenbrok-Kal, M.H., Kock, M.C.J.M. & Hunink, M.G.M. (2007). Lower extremity arterial disease: Multidetector CT angiography - Meta-analysis. Radiology, 245(2), 433-439. Hofman, A., Breteler, M.M.B., Duijn, C.M. van, Krestin, G.P., Pols, H.A., Stricker, B.H.C., Tiemeier, H.W., Uitterlinden, A.G., Vingerling, J.R. & Witteman, J.C.M. (2007). The Rotterdam Study: Objectives and design update. European Journal of Epidemiology, 22(11), 819-829. Huang, L., Lequin, M., Pieters, R. & Eibrink, M.M. (2007). The clinical value of follow-up examinations in childhood T-cell acute lymphoblastic leukemia and T-cell non-Hodgkin lymphoma. Pediatric Blood & Cancer, 48(4), 468-472. Jaegere, P.P.T. de, Dijk, L.C. van, Laborde, J.C., Sianos, G., Ramos, F.J., Ligthart, J.M.R., Kappetein, A.P., Ent, M. van der & Serruys, P.W.J.C. (2007). True percutanious implantation of the CoreValve aortic valve prosthesis by the combined use of ultrasound guided vascular access, Prostar XL and the TandemHeart. EuroIntervention, 2, 500-505. Jong, P.A. de & Tiddens, H.A.W.M. (2007). Cystic fibrosis-specific computed tomography scoring. Proceedings of the American Thoracic Society, 4, 338-342. Keijzer-Veen, M.G., Kleinveld, H.A., Lequin, M.H., Dekker, F.W., Nauta, J., Rijke, Y.B. de & Heijden, A.J. van der (2007). Renal function and size at young adult age after intrauterine growth restriction and very premature birth. American Journal of Kidney Diseases, 50(4), 542-551. Kock, M.C.J.M., Dijkshoorn, M.L., Pattynama, P.M.T. & Hunink, M.G.M. (2007). Multi-detector row computed tomography angiography of peripheral arterial disease. European Radiology, 17(12), 3208-3222. Krestin, G.P. (2007). Challenges for research in radiology. Imaging Management, 7, 18-19. Krestin, G.P. & Thomsen, H.S. (2007). Marketing and communications in radiology. Imaging Management, 7, 24-25. Krestin, G.P. (2007). Molecular imaging and radiology. Imaging Management, 7, 25-26. Krestin, G.P., Miller, JC, Golding, SJ, Frija, GG, Glazer, G.M., Ringertz, HG & Thrall, JH (2007). Reinventing radiology in a digital and molecular age: Summary of proceedings of the sixth biannual symposium of the international society for strategic studies in radiology ((ISR)-R-3), august 25-27, 2005. Radiology, 244(3), 633-638. Kriege, M., Brekelmans, C.T.M., Peterse, H., Obdeijn, A.I.M., Boetes, C., Zonderland, H..M., Muller, S.H., Kok, T. de, Manoliu, R.A., Besnard, APE, Tilanus-Linthorst, M.M.A., Seynaeve, C., Bartels, C.C.M., Meijer, S., Oosterwijk, J.C., Hoogerbrugge, N., Tollenaar, R.A.E.M., Koning, H.J. de, Rutgers, EJT & Klijn, J.G.M. (2007). Tumor characteristics and detection method in the MRISC screening program for the early detection of hereditary breast cancer. Breast Cancer Research and Treatment, 102(3), 357-363. Kruip, M.J.H.A., Vliet, H.H.D.M. van, Pattynama, P.M.T., Kars, A., Meiracker, A.H. van den, Jie, KSG & Leebeek, F.W.G. (2007). Evaluation of the AutoDimer D-climer assay for the exclusion of pulmonary embolism. Thrombosis and Haemostasis, 97(2), 325-326. Monye, C. de, Dippel, D.W.J., Dijkshoorn, M.L., Tanghe, H.L.J. & Lugt, A. van der (2007). MDCT detection of fibromuscular dysplasia of the internal carotid artery. American Journal of Roentgenology, 188(4), W367-W369.

Nijs, S.M.P., Eijsbouts, S.W., Madern, G.C., Leyman, P.M.M., Lequin, M.H. & Hazebroek, F.W.J. (2007). Nonpalpable testes: is there a relationship between ultrasonographic and operative findings? Pediatric Radiology, 37(4), 374-379. Nikken, J.J. & Krestin, G.P. (2007). MRI of the kidney-state of the art. European Radiology, 17(11), 2780-2793. Odink, A.E., Lugt, A. van der, Hofman, A., Hunink, M.G.M., Breteler, M.M.B., Krestin, G.P. & Witteman, J.C.M. (2007). Association between calcification in the coronary arteries, aortic arch and carotid arteries: The Rotterdam study. Atherosclerosis, 193(2), 408-413. Oei, E.H.G., Ginai-Karamat, A.Z. & Hunink, M.G.M. (2007). MRI for traumatic knee injury: A review. Seminars in Ultrasound Ct and Mri, 28(2), 141-157. Ouhlous, M., Moelker, A., Flick, HJ, Wielopolski, P.A., Weert, T.T. de, Pattynama, P.M.T. & Lugt, A. van der (2007). Quadrature coil design for high-resolution carotid artery imaging scores better than a dual phased-array coil design with the same volume coverage. Jmri-Journal of Magnetic Resonance Imaging, 25(5), 1079-1084. Palumbo, A.A., Luccichenti, G., Belgrano, M., Grutta, L. la, Runza, G., Cova, MA, Midiri, M., Pisi, G, Grzincich, GL, Battistini, A & Cademartiri, F. (2007). Three-dimensional quantitative assessment of lung parenchyma in cystic fibrosis: preliminary results. Radiologia Medica, 112(1), 21-30. Pattynama, P.M.T., Wils, A., Linden, E. van der & Dijk, L.C. van (2007). Embolization with the amplatzer vascular plug in TIPS patients. Cardiovascular & Interventional Radiology, 30(6), 1218-1221. Ridder, D. de, Kovacs, S, Smits, M., Peeters, R., Hecke, P Van & Sunaert, S (2007). Comment on Dr. Folmer's letter to the editor entitled "Lateralization of neural activity associated with tinnitus". Neuroradiology, 49(8), 693-696. Rocca, MA, Mondria, T., Valsasina, P, Sormani, MP, Flach, H.Z., Boekhorst, P.A.W. te, Comi, G., Hintzen, R.Q. & Filippi, M. (2007). A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis. American Journal of Neuroradiology, 28(9), 1659-1661. Rollano Hijarrubia, M.E., Niessen, W., Weinans, H., Lugt, A. van der & Stokking, R. (2007). Histogram-based selective deblurring to improve computed tomography imaging of calcifications. Investigative Radiology, 42(1), 8-22. Sallam, B.M., Pilch-Kowalczyk, A., Gruszczynska, K., Baron, J. & Pugliese, F. (2007). Diagnostic performance of CT colonography in a population with high prevalence of large bowel disease. Medical Science Monitor, 13, 105-110. Schepers, T., Schipper, I.B., Vogels, L.M.M., Ginai-Karamat, A.Z., Mulder, P.G.H., Heetveld, M.J. & Patka, P. (2007). Percutaneous treatment of displaced intra-articular calcaneal fractures. Journal of Orthopaedic Science, 12(1), 22-27. Schepers, T., Hartog, D. den, Ginai-Karamat, A.Z. & Patka, P. (2007). Posterior capsular avulsion fracture of the calcaneus: an uncommon avulsion fracture. Journal of Foot & Ankle Surgery, 46(5), 409-410. Schepers, T., Ginai-Karamat, A.Z., Mulder, P.G.H. & Patka, P. (2007). Radiographic evaluation of calcaneal fractures: to measure or not to measure. Skeletal Radiology, 36(9), 847-852. Smits, M., Hunink, M.G.M., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Hofman, PAM, Twijnstra, A., Haan, G.G. de, Tanghe, H.L.J. & Dippel, D.W.J. (2007). A history of loss of consciousness or post-traumatic amnesia in minor head injury: "conditio sine qua non" or one of the risk factors? Journal of Neurology Neurosurgery and Psychiatry, 78(12), 13591364. Smits, M., Peeters, RR, Hecke, P Van & Sunaert, S (2007). A 3 T event-related functional magnetic resonance imaging (fMRI) study of primary and secondary gustatory cortex localization using natural tastants. Neuroradiology, 49(1), 61-71. Smits, M., Dippel, D.W.J. & Hunink, M.G.M. (2007). Cost effectiveness of using computed tomography (CT) for minor head injury compared with several other management strategies + reply. Journal of Trauma-Injury Infection and Critical Care, 62(5), 1314-1315. Smits, M. (2007). fMRI tests assumptions about behavior and thought. Diagnostic Imaging Europe, 5. Smits, M., Vernooij, M.W., Wielopolski, P.A., Vincent, A.J.P.E., Houston, G.C. & Lugt, A. van der (2007). Incorporating functional MR imaging into diffusion tensor tractography in the preoperative assessment of the corticospinal tract in patients with brain tumors. American Journal of Neuroradiology, 28(7), 1354-1361. Smits, M., Kovacs, S, Ridder, D. de, Peeters, RR, Hecke, P Van & Sunaert, S (2007). Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology, 49(8), 669-679. Smits, M., Dippel, D.W.J., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Minor head injury: Guidelines for the use of CT - A multicenter validation study. Radiology, 245(3), 831-838.

Smits, M., Dippel, D.W.J., Steyerberg, E.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: The CHIP prediction rule. Annals of Internal Medicine, 146(6), 397-405. Tilanus-Linthorst, M.M.A., Obdeijn, A.I.M., Hop, W.C.J., Causer, PA, Leach, MO, Warner, E., Pointon, L, Hill, K, Klijn, J.G.M., Warren, RML & Gilbert, FJ (2007). BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials. Clinical Cancer Research, 13(24), 73577362. Veen, R.N. van, Baat, P. de, Heijboer, M.P., Kazemier, G., Punt, B.J., Dwarkasing, R.S., Bonjer, H.J. & Eijck, C.H.J. van (2007). Successful endoscopic treatment of chronic groin pain in athletes. Surgical Endoscopy, 21, 189-193. Velsen, EFS van, Niessen, W.J., Weert, T.T. de, Monye, C. de, Lugt, A. van der, Meijering, H.W. & Stokking, R. (2007). Evaluation of an improved technique for lumen path definition and lumen segmentation of atherosclerotic vessels in CT angiography. European Radiology, 17(7), 1738-1745. Vernooij, M.W., Smits, M., Wielopolski, P.A., Houston, G.C., Krestin, G.P. & Lugt, A. van der (2007). Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and lefthanded healthy subjects: A combined fMRI and DTI study. Neuroimage, 35(3), 1064-1076. Vernooij, M.W., Ikram, M.A., Tanghe, H.L., Vincent, A.J.P.E., Hofman, A., Krestin, G.P., Niessen, W.J., Breteler, M.M.B. & Lugt, A. van der (2007). Incidental findings on brain MRI in the general population. New England Journal of Medicine, 357(18), 1821-1828. Vernooij, M.W. (2007). Many coincidental findings on MRI-scans. Medisch Contact. Vliet, E.P.M. van, Lugt, A. van der, Kuipers, E.J., Tilanus, H.W., Gaast, A. van der, Hermans, J.J. & Siersema, P.D. (2007). Ultrasound, computed tomography, or the combination for the detection of supraclavicular lymph nodes in patients with esophageal or gastric cardia cancer: A comparative study. Journal of Surgical Oncology, 96(3), 200-206. Vries, M. de, Ouwendijk, R., Flobbe, K., Nelemans, P.J., Kessels, A.G., Schurink, G.W., Vliet, J.A. van der, Cuypers, P.W.M., Duijm, L.E.M., Engelshoven, J.M.A. van, Hunink, M.G.M. & Haan, M.W. de (2007). Peripheral artery disease: clinical and cost comparison between duplex ultrasonography and contrast-enhanced magnetic resonance angiography a multicenter randomized trial. Nederlands Tijdschrift voor Geneeskunde, 151, 1789-1794. Vrooman, H.A., Cocosco, CA, Lijn, F. van der, Stokking, R., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B. & Niessen, W.J. (2007). Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification. Neuroimage, 37(1), 71-81. Weustink, A.C. & Krestin, G.P. (2007). Test: Minimal invasive autopsy. Erasmus Magazine, 36, 8-9. Zahringer, M, Sapoval, M, Pattynama, P.M.T., Rabbia, C, Vignali, C, Maleux, G, Boyer, L, Szczerbo-Trojanowska, M, Jaschke, W, Hafsahl, G, Downes, M, Beregi, JP, Veeger, NJGM, Stoll, HP & Talen, A (2007). Sirolimus-Eluting versus bare-metal low-profile Stent for renal artery treatment (GREAT trial): Angiographic follow-up after 6 months and clinical outcome up to 2 years. Journal of Endovascular Therapy, 14(4), 460-468. Part of book - abstract Beukhof, C.M., Lequin, M.H. & Drop, S.L.S. (2007). The classic triad and variants. In C. Deal (Ed.), MRI in congenital hypopituitarism: a reference guide 2007 (pp. 69-80). London: Remedica Medical Education and Publishing. Casciaro, S. & Pattynama, P.M.T. (2007). Radiofrequency ablation of the liver and of the other organs: Current trends and perspective applications a review. In S. Casciaro & E. Samset (Eds.), Novel technologies for minimally invasive therapies (pp. 50-56). Lecce: Lupiensis Biomedical Publications. Freudenthal, A. & Pattynama, P.M.T. (2007). What's in a surgeon's mind? Learning for performing treatments and operating equipment. In S. Casciaro & B Gersak (Eds.), New Technology Frontiers in Minimally Invasive Therapies (pp. 112-121). Lecce: Lupiensis Biomedical Publications. Jalote-Parmar, A., Pattynama, P.M.T., Goossens, R.H.M., Freudenthal, A., Samset, E. & Ridder, H. de (2007). Bridging the gap: A user centered design approach towards developing technological solutions. In S. Casciaro & E Samset (Eds.), Novel technologies for minimally invasive therapies (pp. 93-101). Lecce: Lupiensis Biomedical Publications. Jalote-Parmar, A., Pattynama, P.M.T., Plas, A.P. van der & Heer, P. de (2007). Towards intuitive surgical interfaces: Strategies from video games. In S. Casciaro & B Gersak (Eds.), New technology frontiers in minimally invasive therapies (pp. 101-111). Lecce: Lupiensis Biomedical Publications. Krestin, G.P. (2007). Kidneys and adrenal glands. In R. Felix, N. Hosten, A. Heshiki, H. Hricak & K.H. Chang (Eds.), Magnevist (pp. 159-167). Boston: Blackwell publishing Limited.

Lequin, M.H., Beek, F.J.A., Nievelstein, R.A.J. & Kramer, W.L.M. (2007). Radiodiagnosis in wounded children. In W.L.M. Kramer, H.J. ten Duis, S Ekkelkamp, J.L.L. Kimpen, L.P.H. Leenen & P Patka (Eds.), Handbook of pediatric traumatology (pp. 113-132). Utrecht: De Tijdstroom Uitgeverij. Schaap, M., Manniesing, R, Smal, I., Walsum, T. van, Lugt, A. van der & Niessen, W.J. (2007). Bayesian tracking of tubular structures and its application to carotid arteries in CTA. In L. Rasmus, M. Nielsen & J. Sporring (Eds.), Medical Image Computing and Computer Assisted Intervention (pp. 562-570). NY: Springer. Taupitz, M. & Krestin, G.P. (2007). Adrenal glands. In B Hamm, G.P. Krestin, M. Laniado, V. Nicolas & M. Taupitz (Eds.), MRI of the abdomen and pelvis (pp. 189-204). Stuttgart: Theime-Verlag. Weert, T.T. de, Ouhlous, M., Sambeek, M.R.H.M. van & Lugt, A. van der (2007). CT plaque imaging. In Carotid disease: the role of imaging in diagnosis and management (pp. 191-207). Cambridge: Cambridge University press. Book editorship Hamm, B., Krestin, G.P., Laniado, M., Nicolas, V. & Taupitz, M. (Eds.). (2007). MRI of the abdomen and pelvis. Stuttgart: Theime-Verlag. Newspaper article Lugt, A. van der, Vernooij, M.W. & Breteler, M.M.B. (01-01-2007). Brain scan of ERGO-study participant: A meningeoma (benign tumor). NRC Handelsblad.

EMC NIHES-03-30-02 - Assessment of diagnostic and interventional imaging technology Programme design in brief The research program focuses on the assessment of diagnostic imaging technology and image-guided therapies. The assessment includes clinical efficacy, patient outcomes, and costs-effectiveness. There is a special interest in the assessment of new imaging technology for cardiovascular disease, including such techniques as magnetic resonance angiography, computed tomography angiography, imaging of vulnerable plaque, and molecular imaging. The research methods employed are from clinical epidemiology, decision sciences, and medical technology assessment. The methodological research of the group focuses on developing the methods and study design for evaluating diagnostic imaging technology. The long-term goal of the program is to provide relevant information for implementing evidencebased clinical services. The program is a collaborative effort between the Depts of Radiology and Epidemiology & Biostatistics. Key figures Department

SP1

SP2

SP3

SP4

SPtot

epidemiology & biostatics

2,58

0

0

0

2,58

family practice

0,03

0

0

0

0,03

0,5

0

0

0

0,5

radiology

2,04

0

0

0

2,04

Total

5,15

0

0

0

5,15

internal medicine

T1

T2

3

T3

0

Ttot

0

IS

3

FS

20

OP

4

Ptot

0

Theses Boks, S.S. (2007, maart 21). MRI Imaging in patients with knee injury: an observational study in general practice. EUR (139 pag.). Prom./coprom.: Prof.Dr. M.G.M. Hunink, Dr. S.M.A. Bierma-Zeinstra & Drs. D. Vroegindeweij. Kock, M.C.J.M. (2007, januari 24). Diagnostic imaging of peripheral arterial disease with multi-detector row computed tomography angiography. EUR. Prom./coprom.: Prof.Dr. M.G.M. Hunink & Prof.Dr. P.M.T. Pattynama. Visser, J.J. (2007, november 14). Ruptured abdominal aortic aneurysms: endovascular repair versus open surgery. EUR. Prom./coprom.: Prof.Dr. M.G.M. Hunink, J.L. Bosch & Dr. M.R.H.M. van Sambeek. Article/Letter to the editor Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M. & Bierma-Zeinstra, S.M.A. (2007). Clinical consequences of posttraumatic bone bruise in the knee. American Journal of Sports Medicine, 35(6), 990-995. Boks, S.S., Vroegindeweij, D., Koes, B.W., Bernsen, R.M.D., Hunink, M.G.M. & Bierma-Zeinstra, S.M.A. (2007). MRI follow-up of posttraumatic bone bruises of the knee in general practice. American Journal of Roentgenology, 189(3), 556562. Delahanty, LM, Grant, RW, Wittenberg, E, Bosch, J.L., Wexler, DJ, Cagliero, E & Meigs, JB (2007). Association of diabetes-related emotional distress with diabetes treatment in primary care patients with Type 2 diabetes. Diabetic Medicine, 24(1), 48-54. Groot Koerkamp, B., Hunink, M.G.M., Stijnen, T., Hammitt, J.K., Kuntz, K.M. & Weinstein, M.C. (2007). Limitations of acceptability curves for presenting uncertainty in cost-effectiveness analysis. Medical Decision Making, 27(2), 101-111. Heijenbrok-Kal, M.H., Kock, M.C.J.M. & Hunink, M.G.M. (2007). Lower extremity arterial disease: Multidetector CT angiography - Meta-analysis. Radiology, 245(2), 433-439. Heijenbrok-Kal, M.H., Fleischmann, K.E. & Hunink, M.G.M. (2007). Stress echocardiography, stress sing le-photonemission computed tomography and electron beam computed tomography for the assessment of coronary artery disease: A meta-analysis of diagnostic performance. American Heart Journal, 154(3), 415-423. Helvoort-Postulart, D van, Dirksen, C.D., Nelemans, P.J., Kroon, A.A., Kessels, A.G.H., Leeuw, P.W. de, Vasbinder, G.B.C., Engelshoven, J.M.A. van & Hunink, M.G.M. (2007). Renal artery stenosis: Cost-effectiveness of diagnosis and treatment. Radiology, 244(2), 505-513. Hunink, M.G.M. (2007). Whole-body imaging needs more tailored approach to be effective. Diagnostic Imaging Europe, 23, 5-7. Karger, R, Donner-Banzhoff, N, Muller, HH, Kretschmer, V & Hunink, M. (2007). Diagnostic performance of the platelet function analyzer (PFA-100 (R)) for the detection of disorders of primary haemostasis in patients with a bleeding history a systematic review and meta-analysis. Platelets, 18(4), 249-260. Kock, M.C.J.M., Dijkshoorn, M.L., Pattynama, P.M.T. & Hunink, M.G.M. (2007). Multi-detector row computed tomography angiography of peripheral arterial disease. European Radiology, 17(12), 3208-3222.

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Koller, M.T., Steyerberg, E.W., Wolbers, M, Stijnen, T., Bucher, HC, Hunink, M.G.M. & Witteman, J.C.M. (2007). Validity of the Framingham point scores in the elderly: Results from the Rotterdam study. American Heart Journal, 154(1), 87-93. Liem, Y.S., Wong, J.B., Hunink, M.G.M., Charro, F. de & Winkelmayer, WC (2007). Comparison of hemodialysis and peritoneal dialysis survival in The Netherlands. Kidney International, 71(2), 153-158. Liem, Y.S., Bosch, J.L., Arends, L.R., Heijenbrok-Kal, M.H. & Hunink, M.G.M. (2007). Quality of life assessed with the medical outcomes study short form 36-item health survey of patients on renal replacement therapy: A systematic review and meta-analysis. Value in Health, 10(5), 390-397. Odink, A.E., Lugt, A. van der, Hofman, A., Hunink, M.G.M., Breteler, M.M.B., Krestin, G.P. & Witteman, J.C.M. (2007). Association between calcification in the coronary arteries, aortic arch and carotid arteries: The Rotterdam study. Atherosclerosis, 193(2), 408-413. Oei, E.H.G., Ginai-Karamat, A.Z. & Hunink, M.G.M. (2007). MRI for traumatic knee injury: A review. Seminars in Ultrasound Ct and Mri, 28(2), 141-157. Smits, M., Hunink, M.G.M., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Hofman, PAM, Twijnstra, A., Haan, G.G. de, Tanghe, H.L.J. & Dippel, D.W.J. (2007). A history of loss of consciousness or post-traumatic amnesia in minor head injury: "conditio sine qua non" or one of the risk factors? Journal of Neurology Neurosurgery and Psychiatry, 78(12), 13591364. Smits, M., Dippel, D.W.J. & Hunink, M.G.M. (2007). Cost effectiveness of using computed tomography (CT) for minor head injury compared with several other management strategies + reply. Journal of Trauma-Injury Infection and Critical Care, 62(5), 1314-1315. Smits, M., Dippel, D.W.J., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Minor head injury: Guidelines for the use of CT - A multicenter validation study. Radiology, 245(3), 831-838. Smits, M., Dippel, D.W.J., Steyerberg, E.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: The CHIP prediction rule. Annals of Internal Medicine, 146(6), 397-405. Spronk, S., White, JV, Bosch, J.L. & Hunink, M.G.M. (2007). Impact of claudication and its treatment on quality of life. Seminars in Vascular Surgery, 20(1), 3-9. Vanhoenacker, PK, Heijenbrok-Kal, M.H., Heste, R Van, Decramer, I, Hoe, LR Van, William, W & Hunink, M.G.M. (2007). Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: Meta-analysis. Radiology, 244(2), 419-428. Visser, J.J., Sambeek, M.R.H.M. van, Hama, TH, Hunink, M.G.M. & Bosch, J.L. (2007). Ruptured abdominal aortic aneurysms: Endovascular repair versus open surgery-systematic review. Radiology, 245(1), 122-129. Vries, M. de, Ouwendijk, R., Flobbe, K., Nelemans, P.J., Kessels, A.G., Schurink, G.W., Vliet, J.A. van der, Cuypers, P.W.M., Duijm, L.E.M., Engelshoven, J.M.A. van, Hunink, M.G.M. & Haan, M.W. de (2007). Peripheral artery disease: clinical and cost comparison between duplex ultrasonography and contrast-enhanced magnetic resonance angiography a multicenter randomized trial. Nederlands Tijdschrift voor Geneeskunde, 151, 1789-1794. Wijsmuller, A.R., Veen, R.N. van, Bosch, J.L., Kleinrensink, G.J., Jeekel, J. & Lange, J.F. (2007). Nerve management during open hernia repair. British Journal of Surgery, 94(1), 17-22.

EMC NIHES-03-30-03 - Development of acquisition and processing techniques for diagnostic imaging Programme design in brief The general goal of this research program is to investigate and validate new diagnostic and therapeutic imaging techniques for both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). We focus on image acquisition, processing and segmentation of three (or higher) ?dimensional image data in order to be able to enhance patient care. The main research focuses are the improvement of existing and development new computerized techniques for the segmentation of high-dimensional diagnostic images. Specific goals are (a) to increase the outcome of image segmentation techniques, (b) to develop new ways of visualizing high-dimensional data sets by combining existing techniques (surface and volume rendering) with newly developed methods (virtual reality), and (c) to improve userinterfaces and develop automated procedures to assist the end-user with the post-processing, segmentation and visualization of radiological image data. Furthermore, image registration, data fusion and measuremeents in diagnostic images will be developed and validated. We are also interested in optimizing acquisition protocols so that region-of-interest imaging makes use of the maximum capabilities of our imaging systems. This will benefit both diagnosis and therapeutical monitoring tasks. The initial target is enhanced direct visualization of the epicardial coronary anatomy, by which we can establish the presence, site, severity, and/or status of coronary atherosclerotic disease. Further targets are assessment of ventricular function and characterization of atherosclerotic plaque composition. We will than use the optimized protocols to investigate the diagnostic possibilities and diagnostic accuracy of MR cardiac and coronary imaging and to determine the possible clinical indications for MR imaging of both native coronary artery disease and coronary bypass disease. Molecular Imaging is an area demanding international attention. Acquisition of information on the cellular and molecular level and subsequent analysis is expected to have a profound impact on the diagnosis, monitoring and treatment of diseases that have the potential of being redefined in terms of their characteristics genetic or molecular abnormalities. We are optimizing our imaging systems (with an emphasis on MRI) to provide near-cellular resolution and expect to move into animal studies soon Key figures Department cardiology medical informatics radiology Total

SP1

SP2

SP3

SP4

SPtot

0,4

0

0

0

0,4

3,21

0,5

0

0

3,71

3,2

0,35

0

0

3,55

6,81

0,85

0

0

7,66

T1

T2

1

T3

0

Ttot

0

IS

1

FS

9

OP

3

Ptot

7

Theses Rollano Hijarrubia, M.E. (2007, oktober 24). Imaging of small high-sensity structures in computed tomography. EUR. Prom./coprom.: Prof.Dr. W.J. Niessen. Article/Letter to the editor Alderliesten, T., Konings, M.K. & Niessen, W.J. (2007). Modeling friction, intrinsic curvature, and rotation of guide wires for simulation of minimally invasive vascular interventions. IEEE Transactions on Biomedical Engineering, 54(1), 29-38. Flach, H.Z., Ouhlous, M., Hendriks, J.M., Sambeek, M.R.H.M. van, Veenland, J.F., Dijk, L.C. van & Lugt, A. van der (2007). Diffusion-weighted imaging to compare different cerebral protection devices in carotid artery stenting. EuroIntervention, 3, 243-248. Larsen, R & Niessen, W. (2007). Advances in radiologic image analysis from MICCA 2006. Academic Radiology, 14(11), 1296-1297. Manniesing, R, Viergever, M.A. & Niessen, W.J. (2007). Vessel axis tracking using topology constrained surface evolution. IEEE Transactions on Medical Imaging, 26(3), 309-316. Nevo, ST, Stralen, M. van, Vossepoel, A.M., Reiber, J.H.C., Jong, N. de, Steen, A.F.W. van der & Bosch, J.G. (2007). Automated tracking of the mitral valve annulus motion in apical echocardiographic images using multidimensional dynamic programming. Ultrasound in Medicine and Biology, 33(9), 1389-1399. Rollano Hijarrubia, M.E., Niessen, W., Weinans, H., Lugt, A. van der & Stokking, R. (2007). Histogram-based selective deblurring to improve computed tomography imaging of calcifications. Investigative Radiology, 42(1), 8-22. Schaap, M., Smal, I., Metz, C.T., Walsum, T. van & Niessen, W.J. (2007). Bayesian tracking of elongated structures in 3D images. Information Processing in Medical Imaging, 20, 74-85. Smal, I., Dragestein, K.A., Galjart, N.J., Niessen, W.J. & Meijering, H.W. (2007). Rao-blackwellized marginal particle filtering for multiple object tracking in molecular bioimaging. Information Processing in Medical Imaging, 20, 110-121.

20

Velsen, EFS van, Niessen, W.J., Weert, T.T. de, Monye, C. de, Lugt, A. van der, Meijering, H.W. & Stokking, R. (2007). Evaluation of an improved technique for lumen path definition and lumen segmentation of atherosclerotic vessels in CT angiography. European Radiology, 17(7), 1738-1745. Vermeer, KA, Reus, N.J., Vos, F.M.., Lemiil, HG & Vossepoel, A.M. (2007). Spilt bundle detection in polarimetric images of the human retinal nerve fiber layer. Methods of Information in Medicine, 46(4), 425-431. Vernooij, M.W., Ikram, M.A., Tanghe, H.L., Vincent, A.J.P.E., Hofman, A., Krestin, G.P., Niessen, W.J., Breteler, M.M.B. & Lugt, A. van der (2007). Incidental findings on brain MRI in the general population. New England Journal of Medicine, 357(18), 1821-1828. Vrooman, H.A., Cocosco, CA, Lijn, F. van der, Stokking, R., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B. & Niessen, W.J. (2007). Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification. Neuroimage, 37(1), 71-81. Part of book - abstract Schaap, M., Manniesing, R, Smal, I., Walsum, T. van, Lugt, A. van der & Niessen, W.J. (2007). Bayesian tracking of tubular structures and its application to carotid arteries in CTA. In L. Rasmus, M. Nielsen & J. Sporring (Eds.), Medical Image Computing and Computer Assisted Intervention (pp. 562-570). NY: Springer. Wielopolski, P.A. (2007). Pulse sequences sensitive to Gd-DTPA. In R. Felix, N. Hosten, A. Heshiki, H Hricak & K.H. Chang (Eds.), Magnevist (pp. 13-27). Boston: Blackwell Publishing Limited. Other output Baiker, M., Milles, J., Vossepoel, A.M., Que, I., Kaijzel, EL, Löwik, C.W.G.M., Reiber, J.H.C., Dijkstra, J. & Lelieveldt, B.P.F. (2007). Fully automated whole-body registration in mice using an articulated skeleton atlas. Proceedings of IEEE international symposium on biomedical imaging: from nano to macro: Arlington USA (2007, april 12 - 2007, april 15). Boer, R., Lijn, F. van der, Vrooman, H.A., Vernooij, M.W., Ikram, M.A., Breteler, M.M.B. & Niessen, W.J. (2007). Automatic segmentation of brain tissue and white matter lesions in MRI. Proceedings of IEEE international symposium on biomedical imaging: Macro to Nano: Arlington USA (2007, april 12 - 2007, april 15). Dzyubachyk, O., Niessen, W.J. & Meijering, H.W. (2007). A variational model for level-set based cell tracking in time-lapse fluorescence mirocscopy images. Proceedings of IEEE international symposium on biomedical imaging: from nano to macro: Arlington USA (2007, april 12 - 2007, april 15). Metz, C.T., Schaap, M., Giessen, A.G. van der, Walsum, T. van & Niessen, W.J. (2007). Semi-automatic coronary artery centerline extraction in computed tomography angiography data. Proceedings of IEEE international symposium on biomedical imaging: Macro to Nano Nano: Arlington USA (2007, april 12 - 2007, april 15). Smal, I., Niessen, W.J. & Meijering, H.W. (2007). Advanced particle filtering for multiple object tracking in dynamic fluorescence microscopy images. Proceedings of IEEE international symposium on biomedical imaging: macro to nano: Arlington USA (2007, april 12 - 2007, april 15).

EMC NIHES-03-77-01 - Structuring of medical knowledge Programme design in brief Our first line of research deals with the formalization of medical knowledge, that is the description of knowledge according to a formal representation so that the knowledge can be made operational in a computer system. We do not limit ourselves to knowledge that is provided by experts or is described in journals or books, but also focus on the (semi)automatic extraction of knowledge from documented databases. With respect to documented databases, attention is paid to automated learning techniques for modeling medical knowledge, tailored to the specific problems in the medical domain. This includes research in the representation and use of uncertainty in medical knowledge, and "learning" by computers in interaction with human experts so that the specific strengths of both human and machine are utilized. It is of great importance to test the results of our research (both methodology and prototypes of systems) in the diverse application domains for their usability, in close collaboration with other investigators and clinical partners Key figures Department

SP1

SP2

SP3

SP4

SPtot

medical informatics

1,54

0,94

0

0,59

3,07

Total

1,54

0,94

0

0,59

3,07

T1

T2

1

T3

0

Ttot

0

IS

1

FS

21

OP

5

Ptot

2

Theses Rijnbeek, P.R. (2007, maart 07). Automatic interpretation of pediatric electrocardiograms. EUR. Prom./coprom.: Prof.Dr.Ir. J.H. van Bemmel, Dr.Ir. J.A. Kors & M.C. Witsenburg. Article/Letter to the editor Aarnoudse, A.L.H.J., Newton-Cheh, C, Bakker, PIW de, Straus, S.M.J.M., Kors, J.A., Hofman, A., Uitterlinden, A.G., Witteman, J.C.M. & Stricker, B.H.C. (2007). Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam study. Circulation, 116(1), 10-16. Ammar, K.A., Makwana, R, Jacobsen, SJ, Kors, J.A., Burnett, JC, Redfield, MM, Yawn, B.P. & Rodeheffer, R.J. (2007). Impaired functional status and echocardiographic abnormalities signifying global dysfunction enhance the prognostic significance of previously unrecognized myocardial infarction detected by electrocardiography. Annals of Noninvasive Electrocardiology, 12(1), 27-37. Ammar, K.A., Jacobsen, SJ, Mahoney, DW, Kors, J.A., Redfield, MM, Burnett, JC & Rodeheffer, R.J. (2007). Prevalence and prognostic significance of heart failure stages - Application of the American College of Cardiology/American Heart Association heart failure staging criteria in the community. Circulation, 115(12), 1563-1570. Ball, M.J., Bemmel, J.H. van & Kaihara, S. (2007). IMIA Presendential retrospecitves on medical informatics. IMIA Yearbook, 46, 165-175. Bansard, JY, Rebholz-Schuhmann, D, Cameron, G, Clark, D, Mulligen, E. van, Beltrame, F, Barbolla, ED, MartinSanchez, F., Milanesi, L, Tollis, I, Lei, J. van der & Coatrieux, JL (2007). Medical informatics and bioinformatics: A bibliometric study. Ieee Transactions on Information Technology in Biomedicine, 11(3), 237-243. Finlay, D.D., Nugent, C.D., Kors, J.A., Herpen, G. van, Donnelly, MP, McCullagh, PJ & Black, N.D. (2007). Optimizing the 12-lead electrocardiogram: a data driven approach to locating alternative recording sites. Journal of Electrocardiology, 40(3), 292-299. Geluk, C.A., Dikkers, R., Kors, J.A., Tio, R.A., Slart, R.H., Vliegenthart, R., Hillege, H.L., Willems, T.P., Jong, P.E. de, Gilst, W.H. van, Oudkerk, M. & Zijlstra, F.J. (2007). Measurement of coronary calcium scores or exercise testing as initial screening tool in asymptomatic subjects with ST-T changes on the resting ECG: an evaluation study. BMC Cardiovascular Disorders, 7, 19. Heeringa, J., Kuip, D.A.M. van der, Hofman, A., Kors, J.A., Rooij, F.J.A. van, Lip, G.Y.H. & Witteman, J.C.M. (2007). Subclinical atherosclerosis and risk of atrial fibrillation - The Rotterdam study. Archives of Internal Medicine, 167(4), 382387. Hettne, K.M., Mos, M. de, Bruijn, A.G.J. de, Weeber, M., Boyer, S, Mulligen, E.M. van, Cases, M, Mestres, J & Lei, J. van der (2007). Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in complex regional pain syndrome. Journal of Biomedical Discovery and Collaboration, 2, 2. Hettne, K.M., Weeber, M., Laine, ML, Cate, H. ten, Boyer, S, Kors, J.A. & Loos, BG (2007). Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study. Journal of Clinical Periodontology, 34(12), 1016-1024. Jelier, R., Jenster, G., Dorssers, L.C.J., Wouters, B.J., Hendriksen, P.J.M., Mons, B., Delwel, R. & Kors, J.A. (2007). Textderived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation. Bmc Bioinformatics, 8.

29

Kligfield, P, Gettes, LS, Bailey, JJ, Childers, R, Deal, BJ, Hancock, EW, Herpen, G. van, Kors, J.A., Macfarlane, P, Mirvis, DM, Pahlm, O., Rautaharju, P & Wagner, G.S. (2007). Recommendations for the standardization and interpretation of the electrocardiogram - Part I: The electrocardiogram and its technology - A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Journal of the American College of Cardiology, 49(10), 1109-1127. Kligfield, P, Gettes, LS, Bailey, JJ, Childers, R, Deal, BJ, Hancock, EW, Herpen, G. van, Kors, J.A., Macfarlane, P, Mirvis, DM, Pahlm, O., Rautaharju, P & Wagner, G.S. (2007). Recommendations for the standardization and interpretation of the electrocardiogram - Part I: The electrocardiogram and its technology - A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society - Endorsed by the International Society for Computerized Electrocardiology. Circulation, 115(10), 1306-1324. Kligfield, P, Gettes, LS, Bailey, JJ, Childers, R, Deal, BJ, Hancock, EW, Herpen, G. van, Kors, J.A., Macfarlane, P, Mirvis, DM, Pahlm, O., Rautaharju, P & Wagner, G.S. (2007). Recommendations for the standardization and interpretation of the electrocardiogram - The electrocardiogram and its technology - A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society - Endorsed by the International Society for Computerized Electrocardiology. Heart Rhythm, 4(3), 394-412. Kors, J.A., Swenne, C.A. & Greiser, K.H. (2007). Cardiovascular disease, risk factors, and heart rate variability in the general population. Journal of Electrocardiology, 40(1), S19-S21. Rebholz-Schuhman, D, Cameron, G, Clark, D, Mulligen, E. van, Coatrieux, JL, Barbolla, ED, Martin-Sanchez, F., Milanesi, L, Porro, I, Beltrame, F, Tollis, I & Lei, J. van der (2007). SYMBIOmatics: Synergies in Medical Informatics and Bioinformatics - exploring current scientific literature for emerging topics. Bmc Bioinformatics, 8. Ritsema van Eck, H.J., Postema, PG, Herpen, G. van, Wilde, A.A.M. & Kors, J.A. (2007). Dynamic changes of the TU complex in the electrocardiogram. Journal of Electrocardiology, 40(1), S22-S25. Ritsema van Eck, H.J., Kors, J.A. & Herpen, G. van (2007). Effect of ischemic action potentials on T and U waves in the electrocardiogram. Journal of Electrocardiology, 40(4), 76. Schuemie, M., Chichester, C, Lisacek, F, Coute, Y, Roes, P., Sanchez, JC, Kors, J. & Mons, B. (2007). Assignment of protein function and discovery of novel nucleolar proteins based on automatic analysis of MEDLINE. Proteomics, 7(6), 921-931. Schuemie, M.J., Mons, B., Weeber, M. & Kors, J.A. (2007). Evaluation of techniques for increasing recall in a dictionary approach to gene and protein name identification. Journal of Biomedical Informatics, 40(3), 316-324. Smilde, T.D.J., Zuurman, MW, Hillege, H.L., Veldhuisen, D.J., Gilst, W.H. van, Steege, G van der, Voors, AA, Kors, J.A., Jong, P.E. de & Navis, G (2007). Renal function dependent association of AGTR1 polymorphism (A1166C) and Electrocardiographic left-ventricular hypertrophy. American Journal of Hypertension, 20(10), 1097-1103. Smits, M., Hunink, M.G.M., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Hofman, PAM, Twijnstra, A., Haan, G.G. de, Tanghe, H.L.J. & Dippel, D.W.J. (2007). A history of loss of consciousness or post-traumatic amnesia in minor head injury: "conditio sine qua non" or one of the risk factors? Journal of Neurology Neurosurgery and Psychiatry, 78(12), 13591364. Smits, M., Dippel, D.W.J., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Minor head injury: Guidelines for the use of CT - A multicenter validation study. Radiology, 245(3), 831-838. Smits, M., Dippel, D.W.J., Steyerberg, E.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, DR, Nederkoorn, P.J., Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2007). Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: The CHIP prediction rule. Annals of Internal Medicine, 146(6), 397-405. Soekhoe, J.K., Groenen, M.J.M., Ginneken, A.M. van, Khaliq, G., Lesterhuis, W., Tilburg, A.J.P. van & Ouwendijk, RJT (2007). Computerized endoscopic reporting is no more time-consuming than reporting with conventional methods. European Journal of Internal Medicine, 18(4), 321-325. Venema, A.C., Ginneken, A.M. van, Wilde, M. de & Bogers, A.J.J.C. (2007). Is OpenSDE an alternative for dedicated medical research databases? An example in coronary surgery. BMC Medical Informatics and Decision Making, 7(1), 31. Other output Schuemie, M.J., Trieschnigg, D. & Kraaij, W. (2007). Cross language information retrieval for biomedical literature. The Sixteenth Text REtrieval Conference (TREC 2007): Gaithersburg (2007, november 06 - 2007, november 09).

Schuemie, M.J., Jelier, R. & Kors, J.A. (2007). Peregrine: Lightweight gene name normalization by dictionary lookup. Proceedings of the Biocreative 2 workshop 2007: Madrid (2007, april 23 - 2007, april 25).

EMC NIHES-03-77-02 - Structuring of medical data Programme design in brief Medical data recorded in the context of clinical care should not only be available for patient care, but also be accessible for other purposes, such as scientific research, quality assurance, or management. The use of computers to record medical data is a necessary first step to allow data to be used for multiple purposes. Scientific research, however, has shown that the purpose of data collection is closely related to the nature and content of the data recorded. Different usage of the data creates different demands: data requirements in the context of a clinical trial are different than those in the context of management or quality assurance. In the research theme Structuring of Medical Data, the department of Medical Informatics studies methodologies that allow recording of data for multiple purposes. Our research is focused on generic models for medical data. The scientific challenge is to formulate generic models that are applicable to different specialties. The models, however, have to be usable in daily practice. An essential part of this research, therefore, is the validation of these models in daily care. Once electronic patient records are available, our research focus shifts to on the actual use of the data for multiple purposes. Together with clinicians, we study systems aimed at improving the quality of care. Together with other disciplines we also analyze observational databases and study issues involved in naturalistic trials. Key figures Department epidemiology & biostatics

SP1

SP2

SP3

SP4

SPtot

0

0,16

0

0,34

0,5

medical informatics

0,67

2,69

0

1,87

5,23

Total

0,67

2,85

0

2,21

5,73

T1

T2

1

T3

0

Ttot

0

IS

1

FS

45

OP

2

Ptot

1

Theses Rollano Hijarrubia, M.E. (2007, oktober 24). Imaging of small high-sensity structures in computed tomography. EUR. Prom./coprom.: Prof.Dr. W.J. Niessen. Article/Letter to the editor Aarnoudse, A.L.H.J., Dieleman, J.P. & Stricker, B.H.C. (2007). Age- and gender-specific incidence of hospitalisation for digoxin intoxication. Drug Safety, 30(5), 431-436. Becker, M.L., Visser, L.E., Trienekens, P.H., Hofman, A., Schaik, R.H.N. van & Stricker, B.H.C. (2007). Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type 2 diabetes mellitus. Pharmacoepidemiology and Drug Safety, 16, S154-S154. Becker, M.L., Caspers, PWJ, Kallewaard, M., Bruinink, RJ, Kylstra, NB, Heisterkamp, S., Valk, V. de, Veen, AA van der & Stricker, B.H.C. (2007). Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands. Pharmacy World & Science, 29(2), 51-57. Becker, M.L., Kallewaard, M., Caspers, PWJ, Visser, L.E., Leufkens, H.G.M. & Stricker, B.H.C. (2007). Hospitalisations and emergency department visits due to drug-drug interactions: a literature review. Pharmacoepidemiology and Drug Safety, 16(6), 641-651. Benner, JS, Cherry, SB, Erhardt, L, Fernandes, M, Flammer, M, Gaciong, Z, Girerd, X, Johnson, ES, Garcia-Puig, J, Sturkenboom, M.C.J.M. & Sun, W (2007). Rationale, design, and methods for the risk evaluation and communication health outcomes and utilization trial (REACH OUT). Contemporary Clinical Trials, 28(5), 662-673. Bornebroek, M., Lau, L.M.L. de, Haag, M.D.M., Koudstaal, P.J., Hofman, A., Stricker, B.H.C. & Breteler, M.M.B. (2007). Nonsteroidal anti-inflammatory drugs and the risk of parkinson disease. Neuroepidemiology, 28, 193-196. Brink, J.L. van den, Moorman, P.W., Boer, M.F. de, Hop, W.C.J., Pruijn, J.F.A., Verwoerd, C.D.A. & Bemmel, J.H. van (2007). Impact on quality of life of a telemedicine system supporting head and neck cancer patients: A controlled trial during the postoperative period at home. Journal of the American Medical Informatics Association, 14(2), 198-205. Burke, T.A., Sturkenboom, M.C.J.M., Ohman-Strickland, P.A., Wentworth, CE & Rhoads, GG (2007). The effect of antihypertensive drugs and drug combinations on the incidence of new-onset type-2 diabetes mellitus. Pharmacoepidemiology and Drug Safety, 16, 979-987. Gonzalez Zuloeta Ladd, A.M., Arias Vasquez, A., Siemes, C., Yazdan Panah, M., Coebergh, J.W.W., Hofman, A., Stricker, B.H.C. & Duijn, C.M. van (2007). Differential roles of angiotensinogen and angiotensin receptor type 1 polymorphisms in breast cancer risk. Breast Cancer Research and Treatment, 101(3), 299-304. Gonzalez Zuloeta Ladd, A.M., Liu, F., Houben, M.P.W.A., Arias Vasquez, A., Siemes, C., Janssens, A.C.J.W., Coebergh, J.W.W., Hofman, A., Janssen, J.A.M.J.L., Stricker, B.H.C. & Duijn, C.M. van (2007). IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. European Journal of Cancer, 43(11), 1718-1722.

49

Gonzalez Zuloeta Ladd, A.M., Arias Vasquez, A., Siemes, C., Coebergh, J.W.W., Hofman, A., Witteman, J.C.M., Uitterlinden, A., Stricker, B.H.C. & Duijn, C.M. van (2007). Transforming-growth factor beta(1) Leu10Pro polymorphism and breast cancer morbidity. European Journal of Cancer, 43(2), 371-374. Govaere, E., Gysel, D. van, Massa, G, Verhamme, K.M.C., Doli, E & Baets, F. de (2007). The influence of age and gender on sensitization to aero-allergens. Pediatric Allergy and Immunology, 18(8), 671-678. Graaf, J.C. & Vlug, A.E. (2007). Dutch virtual integration of healthcare information. Methods of Information in Medicine, 46, 458-462. Gysel, D. van, Govaere, E., Verhamme, K., Doli, E & Baets, F. de (2007). The influence of atopic status and potential risk factors for sensitization on histamine skin reactivity in unselected Belgian children. Pediatric Dermatology, 24(4), 363-368. Hofman, A., Breteler, M.M.B., Duijn, C.M. van, Krestin, G.P., Pols, H.A., Stricker, B.H.C., Tiemeier, H.W., Uitterlinden, A.G., Vingerling, J.R. & Witteman, J.C.M. (2007). The Rotterdam Study: Objectives and design update. European Journal of Epidemiology, 22(11), 819-829. Hutchison, A, Farmer, R, Verhamme, K., Berges, R & Navarrete, RV (2007). The efficacy of drugs for the treatment of LUTS/BPH, a study in 6 European countries. European Urology, 51(1), 207-216. Isaacs, A.J., Aulchenko, Y.S., Hofman, A., Sijbrands, E.J.G., Sayed-Tabatabaei, F.A., Klungel, O.H., Zee, AHMVD, Stricker, B.H.C., Oostra, B.A., Witteman, J.C.M. & Duijn, C.M. van (2007). Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. Journal of Clinical Endocrinology and Metabolism, 92(7), 2680-2687. Isaacs, A.J., Sayed-Tabatabaei, F.A., Hofman, A., Oostra, B.A., Klungel, O.H., Zee, AHMV, Stricker, B.H.C., Witteman, J.C.M. & Duijn, C.M. van (2007). The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study. European Journal of Cardiovascular Prevention & Rehabilitation, 14(3), 419-421. Lau, L.M.L. de, Stricker, B.H.C. & Breteler, M.M.B. (2007). Serum cholesterol, use of lipid-lowering drugs, and risk of Parkinson Disease. Movement Disorders, 22(13), 1985-1985. Lei, J. van der & Sturkenboom, M. (2007). Of new times, new opportunities, and old problems. European Journal of Epidemiology, 22(5), 281-283. Madaric, J, Vanderheyden, M, Laethem, C Van, Verhamme, K., Feys, A, Goethals, M, Verstreken, S, Geelen, P, Penicka, M, Bruyne, B. de & Bartunek, J (2007). Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance. European Heart Journal, 28(17), 2134-2141. Mangunkusumo, R.T., Brug, J., Duisterhout, J.S., Koning, H.J. de & Raat, H. (2007). Feasibility, acceptability, and quality of internet-administered adolescent helath promotion in a preventive-care setting. Health Education Research, 22(1), 113. Mangunkusumo, R.T., Brug, J., Koning, H.J. de, Lei, J. van der & Raat, H. (2007). School-based Internet-tailored fruit and vegetable education combined with brief counselling increases children's awareness of intake levels. Public Health Nutrition, 10(3), 273-279. Mos, M. de, Bruijn, A.G.J. de, Huygen, F.J.P.M., Dieleman, J.P., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). The incidence of complex regional pain syndrome: A population-based study. Pain, 129(1-2), 12-20. Muskens, R.P.H.M., Voogd, S. de, Wolfs, R.C.W., Witteman, J.C.M., Hofman, A., Jong, P.T.V.M. de, Stricker, B.H.C. & Jansonius, N.M. (2007). Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology, 114(12), 2221-2226. Poleij, M.J., Edelenbos, K.I., Mosseveld, B.M.T., Wijk, M.A.M. van, Bakker, D.H. de, Lei, J. van der & Molken, M.P.M.H. van (2007). Cost consequences of implementing an electronic decision support system for ordering laboratory tests in primary care: Evidence from a controlled prospective study in the Netherlands. Clinical Chemistry, 53(2), 213-219. Raat, H., Mangunkusumo, R.T., Mohangoo, A.D., Juniper, EF & Lei, J. van der (2007). Internet and written respiratory questionnaires yield equivalent results for adolescents. Pediatric Pulmonology, 42(4), 357-361. Rijn, M.J.E. van, Bos, M.J., Isaacs, A.J., Yazdan Panah, M., Arias Vasquez, A., Stricker, B.H.C., Klungel, O.H., Oostra, B.A., Koudstaal, P.J., Witteman, J.C.M., Hofman, A., Breteler, M.M.B. & Duijn, C.M. van (2007). Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Journal of Neurology Neurosurgery and Psychiatry, 78, 1083-1087. Roukema, J., Steyerberg, E.W., Meurs, A.H.J. van, Ruige, M, Lei, J. van der & Moll, H.A. (2007). Validity of the Manchester Triage System in paediatric emergency care. Emergency Medicine Journal, 23(12), 906-910.

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Yazdan Panah, M., Danser, A.H.J., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. European Journal of Human Genetics, 15(4), 478-484. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B. (2007). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 7(5), 346352. Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., Duijn, C.M. van, Boer, A. & Stricker, B.H.C. (2007). Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. British Journal of Clinical Pharmacology, 64(1), 57-66. Soest, E.M. van, Sturkenboom, M.C.J.M., Dieleman, J.P., Verhamme, K.M.C., Siersema, P.D. & Kuipers, E.J. (2007). Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage. Alimentary Pharmacology & Therapeutics, 26(2), 265-275. Soest, E.M. van, Dieleman, J.P., Siersema, P.D., Schoof, L., Sturkenboom, M.C.J.M. & Kuipers, E.J. (2007). Tricyclic antidepressants and the risk of reflux esophagitis. American Journal of Gastroenterology, 102(9), 1870-1877. Teichert, M., Smet, P.A.G.M. de, Hofman, A., Witteman, J.C.M. & Stricker, B.H.C. (2007). Discontinuation of beta-blockers and the risk of myocardial infarction in the elderly. Drug Safety, 30(6), 541-549. Trifiro, G., Verhamme, K.M.C., Ziere, G., Caputi, AP, Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). All-cause mortality associated with atyical and typical antipsychotics in demented outpatients. Pharmacoepidemiology and Drug Safety, 16(5), 538-544. Velde, N. van der, Stricker, B.H.C., Roelandt, J.R.T.C., Cate, F.J. ten & Cammen, T.J.M. van der (2007). Can echocardiographic findings predict falls in older persons? PLoS One, 2, 654. Velde, N. van der, Meiracker, A.H. van den, Stricker, B.H.C. & Cammen, T.J.M. van der (2007). Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant? Blood Pressure Monitoring, 12(3), 167-171. Velde, N. van der, Stricker, B.H.C., Pols, H.A.P. & Cammen, T.J.M. van der (2007). Risk of falls after withdrawal of fallrisk-increasing drugs: a prospective cohort study. British Journal of Clinical Pharmacology, 63(2), 232-237. Velde, N. van der, Stricker, B.H.C., Pols, H.A.P. & Cammen, T.J.M. van der (2007). Withdrawal of fall-risk-increasing drugs in older persons - Effect on mobility test outcomes. Drugs & Aging, 24(8), 691-699. Velde, N. van der, Meiracker, A.H. van den, Pols, H.A.P., Stricker, B.H.C. & Cammen, T.J.M. van der (2007). Withdrawal of fall-risk-increasing drugs in older persons: Effect on tilt-table test outcomes. Journal of American Geriatrics Society, 55(5), 734-739. Verhamme, K.M.C. & Sturkenboom, M.C.J.M. (2007). Mortality in men admitted to hospital with acute urinary retention. British Medical Journal (International Edition), 335(7631), 1164-1165. Verhamme, K.M.C., Coster, W De, Roo, L De, Beenhouwer, H De, Nollet, G, Verbeke, J, Demeyer, I & Jordens, P (2007). Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia. Infection Control & Hospital Epidemiology, 28(4), 389-397. Verhamme, K.M.C., Mosis, G., Dieleman, J.P., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2007). Toegenomen kans op gastro-intestinale bloedingen of ulcera bij gebruik van spironolacton: patient-controlestudie. Nederlands Tijdschrift voor Geneeskunde, 151, 1515-1521. Visser, L.E., Schaik, R.H.N. van, Danser, A.H.J., Hofman, A., Witteman, J.C.M., Duijn, C.M. van, Uitterlinden, A.G., Pols, H.A.P. & Stricker, B.H.C. (2007). The risk of myocardial infarction in patients with reduced activity of cytochrome P4502C9. Pharmacogenetics Genomics, 17(7), 473-479. Yazdan Panah, M., Aulchenko, Y.S., Hofman, A., Janssen, J.A., Sayed-Tabatabaei, F.A., Schaik, R.H.N. van, Klungel, O.H., Stricker, B.H.C., Pols, H.A.P., Witteman, J.C.M., Lamberts, S.W.J., Oostra, B.A. & Duijn, C.M. van (2007). Effects of the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes. Diabetes, 56, 1905-1912. Ziere, G., Dieleman, J.P., Cammen, T.J.M. van der & Stricker, B.H.C. (2007). Association between SSRI use and fractures and the effect of confounding by indication. Archives of Internal Medicine, 167(21), 2369-2370. Part of book - abstract

Sturkenboom, M.C.J.M. (2007). Other databases in Europe the analytic evaluation of drug effects. In R. Mann & E. Andrews (Eds.), Pharmacovigilance. John Wiley & Sons.

EMC NIHES-04-55-01 - Assessment, aetiology and course of child and adolescent psychiatry Programme design in brief The main objective of this programme is to study the frequency, determinants and course of child psychiatric disorders, such as anxiety, depression, somatoform disorders, aggressive and antisocial behaviours, hyperactivity, and developmental problems (autism, learning disorders, mental retardation). The program uses epidemiological methods to study psychopathology in general population, at risk, and clinical samples. These studies aim to develop assessment instruments and diagnostic procedures; assess the prevalence and incidence of child and adolescent disorders; study the onset and course of psychopathology from infancy to young adulthood using longitudinal and genetically sensitive research designs; assess the effectiveness of preventive and treatment approaches. -General population studies The prevalence and course of child and adolescent psychiatric conditions has been studied in Dutch general population samples across the age range from 2 to 30 years. The influence of life events and personal and social-environmental determinants has been studied, and cross-cultural and secular trend analyses have been performed. These studies confirmed the high prevalence (7%) of serious psychiatric problems in Dutch children and adolescents as well as the cross-cultural similarity of child/adolescent psychopathology, and indicated that the use of mental health services at this age is mainly determined by severity of psychopathology, additional handicaps, and family burden. Longitudinal studies showed that earlier psychopathology is the strongest predictor of later psychopathology from childhood up to early adulthood, and is a strong predictor of later functional problems. Recently, the transgenerational transmission of psychopathology is being studies in a 24-year longitudinal design in which parental ratings of children¿s problem behaviour is compared with ratings on the same instrument obtained for the offspring 24 years later. Studies in general population samples also yielded improvements in the standardized assessment of psychopathology, ad well as contributions to the methodology of longitudinal studies (accelerated designs; developmental pathway analysis). The second generation of longitudinal studies in which determinants of the emergence and continuity of child psychopathology is being studied is well on its way. The focus is on two new large-scale longitudinal studies have been set up. The first, Generation R, is a multidisciplinary cohoartstudy following 10.000 children from prebirthgnancy into young adulthood. The second, Trails, is a cohoartstudy of 2.500 10-year-olds in the northern provinces. . The Rotterdam group focuses on anxiety disorders, illegal substance use, and conduct disorders. Both Generation R and Trails aim to unravel etiological mechanisms, with a special focus on biological determinants and gene-enviroment interactions and correlations. The first results of Generation R show the effects of smoking (both cannabis and cigarettes) on intrauterine growth and on early brain development. In Trails the associations between between autonomous nervous functioning and HPA axis functioning with both externalizing and internalizing problems have been studied. -At risk and clinical populations We have assessed the prevalence and longitudinal course of problem behaviours and quality of life in ethnic minority groups, adopted children, children and adolescents with mental retardation, children with psychiatric conditions, and children with medical conditions (e.g. craniofacial abnormalities, congentiac cardiac conditionj). Several studies on referred samples showed a very strong continuity of psychopathology up to 10 years after referral. Only few factors (learning problems, temperament, stress, family functioning) showed predictive power of later psychopathology over and above severity of earlier psychopathology. However, (chronic) physical problems appear to have considerable power in the prediction of later psychopathology (e.g. in mentally retarded children and adolescents). Studies on samples with chronic somatic disorders show the importance of cerebral involvement in child development, as well as the important role of psychological and personality factors in coping with these conditions. Intervention studies aiming anxiety disorders have started. -Behavioural genetics In collaboration with the Free University Amsterdam, we have conducted (longitudinal) twin and adoption studies to determine genetic and environmental influences on problem behaviours in young children. Recent findings show changes in genetic influences on psychopathology from preschool- to school age, differential genetic and environmental influences on co-morbid psychopathological problems as well as genetic influences on the stability of problem behaviours. Considerable contributions have been made to the development of estimation methods in quantitative behavioural genetics (e.g. rater bias models). The behavioural genetic studies continue the study of large genetically sensitive samples (twins; adopted children) well into puberty using longitudinal designs and now include the detection of genetically sensitive syndromes of psychopathology (e.g. disruptive disorders). Key figures Department Generation R

SP1

SP2

SP3

SP4

SPtot

0

0,5

0

0

0,5

pediatric psychiatry

5,2

6,57

0,22

8,26

20,25

Total

5,2

7,07

0,22

8,26

20,75

T1

T2

4

T3

0

Ttot

0

IS

4

FS

51

OP

3

Ptot

14

Theses Bruin, E.I. de (2007, januari 24). The chaotic mind: A study of children with thought disorders and social contact problems. EUR (135 pag.). Prom./coprom.: Prof.Dr. F. Verheij & Dr. R.F. Ferdinand. Greaves-Lord, K. (2007, oktober 05). The role of cardiovascular regulation and cortisol in the development of anxiety in early adolescence. EUR (157 pag.). Prom./coprom.: Prof.Dr. F.C. Verhulst, J. Ormel & Dr. A.C. Huizink.

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Kallen, V.L. (2007, oktober 31). Attentional bias and physiological stress snesitivity in children and adolescents with an anxiety disorder. EUR (159 pag.). Prom./coprom.: Prof.Dr. F.C. Verhulst, prof.dr. Ph.D.A. Treffers & Dr. J.H.M. Tulen. Tick, N.T. (2007, september 26). Time trends in Dutch children s mental health. EUR (144 pag.). Prom./coprom.: Prof.Dr. F.C. Verhulst. Article/Letter to the editor Berg, J.F. van den, Tulen, J.H.M., Neven, AK, Hofman, A., Miedema, HME, Witteman, J.C.M. & Tiemeier, H.W. (2007). Sleep duration and hypertension are not associated in the elderly. Hypertension, 50(3), 585-589. Boer, S.B.B. de, Verheij, F. & Donker, M. (2007). Wat hebben Jeugdgezondheidszorgdossiers voor ons te verbergen? MGV, 62, 640-649. Bruin, E.I. de, Verheij, F., Wiegman, T. & Ferdinand, R.F. (2007). Assessment of formal thought disorder: The relation between the Kiddie Formal Thought Disorder Rating Scale and clinical judgment. Psychiatry Research, 149(1-3), 239-246. Bruin, E.I. de, Ferdinand, R.F., Meester, S., Nijs, P.F.A. de & Verheij, F. (2007). High rates of psychiatric co-morbidity in PDD-NOS. Journal of Autism and Developmental Disorders, 37(5), 877-886. Bruin, E.I. de, Nijs, P.F.A. de, Verheij, F., Hartman, C.A. & Ferdinand, R.F. (2007). Multiple complex developmental disorder delineated from PDD-NOS. Journal of Autism and Developmental Disorders, 37(6), 1181-1191. Bruin, E.I. de & Verheij, F. (2007). Vingerlengteratio. Verschillen tussen jongens met autisme, PDD-NOs, ADHD en angststoornissen. W.T.A., 3, 106-109. Brunnekreef, JA, Sonneville, L.M.J. de, Althaus, M, Minderaa, R.B., Oldehinkel, A.J., Verhulst, F.C. & Ormel, J. (2007). Information processing profiles of internalizing and externalizing behavior problems: evidence from a population-based sample of preadolescents. Journal of Child Psychology and Psychiatry, 48(2), 185-193. Dekker, M.C., Ferdinand, R.F., Lang, N.D.J. van, Bongers, I.L., Ende, J. van der & Verhulst, F.C. (2007). Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome. Journal of Child Psychology and Psychiatry, 48(7), 657-666. Douma, J.C.H., Dekker, M.C., Ruiter, K.P. de, Tick, N.T. & Koot, HM (2007). Antisocial and delinquent behaviors in youths with mild or borderline disabilities. American Journal on Mental Retardation, 112(3), 207-220. Douma, J.C.H. & Dekker, M.C. (2007). Antisociale gedragingen van jongeren met lichte verstandelijke beperkingen. Kind en Adolescent, 28, 182-196. Emond, A, Ormel, J., Veenstra, R. & Oldehinkel, A.J. (2007). Preschool behavioral and social-cognitive problems as predictors of (pre)adolescent disruptive behavior. Child Psychiatry & Human Development, 38(3), 221-236. Ferdinand, R.F., Dieleman, G., Ormel, J. & Verhulst, F.C. (2007). Homotypic versus heterotypic continuity of anxiety symptoms in young adolescents: Evidence for distinctions between DSM-IV subtypes. Journal of Abnormal Child Psychology, 35(3), 325-333. Ferdinand, R.F., Ende, J. van der & Verhulst, F.C. (2007). Parent-teacher disagreement regarding behavioral and emotional problems in referred children is not a risk factor for poor outcome. European Child & Adolescent Psychiatry, 16(2), 121-127. Ferdinand, R.F., Ende, J. van der & Verhulst, F.C. (2007). Parent-teacher disagreement regarding psychopathology in children: a risk factor for adverse outcome? Acta Psychiatrica Scandinavica, 115(1), 48-55. Ferdinand, R.F. (2007). Predicting anxiety diagnoses with the youth self-report. Depression and Anxiety, 24(1), 32-40. Greaves-Lord, K., Ferdinand, R.F., Oldehinkel, A.J., Sondeijker, F.E.P.L., Ormel, J. & Verhulst, F.C. (2007). Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatrica Scandinavica, 116(2), 137-144. Greaves-Lord, K., Ferdinand, R.F., Sondeijker, F.E.P.L., Dietrich, A, Oldehinkel, A.J., Rosmalen, J..G.M., Ormel, J. & Verhulst, F.C. (2007). Testing the tripartite model in young adolescents: Is hyperarousal specific for anxiety and not depress ion? Journal of Affective Disorders, 102(1-3), 55-63. Herba, C.M., Heining, M., Young, A.W., Browning, M., Benson, P.J., Philips, M.L. & Gray, J.A. (2007). Conscious and non-conscious discrimination of facial expressions. Visual Cognition, 15(1), 36-47. Herba, C.M., Ferdinand, R.F., Ende, J. van der & Verhulst, F.C. (2007). Long-term associations of childhood suicide ideation. Journal of the American Academy Child Adolescent Psychiatry, 46(11), 1473-1481.

Hillegers, M.H.J., Reichart, C.G., Wals, M., Verhulst, F.C., Ormel, J., Nolen, W.A. & Drexhage, H.A. (2007). Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents. European Neuropsychopharmacology, 17(6-7), 394-399. Hofman, A., Breteler, M.M.B., Duijn, C.M. van, Krestin, G.P., Pols, H.A., Stricker, B.H.C., Tiemeier, H.W., Uitterlinden, A.G., Vingerling, J.R. & Witteman, J.C.M. (2007). The Rotterdam Study: Objectives and design update. European Journal of Epidemiology, 22(11), 819-829. Huizink, A.C., Dick, DM, Sihvola, E, Pulkkinen, L., Rose, RJ & Kaprio, J (2007). Chernobyl exposure as stressor during pregnancy and behaviour in adolescent offspring. Acta Psychiatrica Scandinavica, 116(6), 438-446. Huizink, A.C., Berg, M.P. van den, Ende, J. van der & Verhulst, F.C. (2007). Longitudinal genetic analysis of internalizing and externalizing problem behavior in adopted biologically related and unrelated sibling pairs. Twin Research and Human Genetics, 10(1), 55-65. Ivanova, MY, Achenbach, T.M., Dumenci, L, Rescorla, LA, Almqvist, F, Bathiche, M., Bilenberg, N, Bird, H, Domuta, A., Erol, N., Fombonne, E., Fonseca, AC, Frigerio, A, Kanbayashi, Y, Lambert, M.C., Leung, P, Liu, X., Minaei, A, Roussos, A, Simsek, Z, Weintraub, S, Wolanczyk, T, Zubrick, S.R., Zukauskiene, R & Verhulst, F.C. (2007). Testing the teacher's report form syndromes in 20 societies. School Psychology Review, 36, 468-483. Ivanova, MY, Achenbach, T.M., Dumenci, L, Almqvist, F, Weintraub, S, Bilenberg, N, Bird, H, Chen, WJ, Dobrean, A, Dopfner, M, Erol, N., Fombonne, E., Fonseca, AC, Frigerio, A, Grietens, H, Hannesdottir, H, Kanbayashi, Y, Lambert, M, Larsson, B., Leung, P, Liu, X., Minaei, A, Mulatu, MS, Novik, TS, Oh, KJ, Roussos, A, Sawyer, M, Simsek, Z, Steinhausen, HC, Metzke, CW, Wolanczyk, T, Yang, HJ, Zilber, N., Zukauskiene, R & Verhulst, F.C. (2007). Testing the 8-syndrome structure of the child behavior checklist in 30 societies. Journal of Clinical Child and Adolescent Psychology, 36(3), 405-417. Ivanova, MY, Achenbach, T.M., Rescorla, LA, Dumenci, L, Almqvist, F, Bilenberg, N, Bird, H, Broberg, AG, Dobrean, A, Dopfner, M, Erol, N., Forns, M, Hannesdottir, H, Kanbayashi, Y, Lambert, M.C., Leung, P, Minaei, A, Mulatu, MS, Novik, T, Oh, KJ, Roussos, A, Sawyer, M, Simsek, Z, Steinhausen, HC, Weintraub, S, Metzke, CW, Wolanczyk, T, Zilber, N., Zukauskiene, R & Verhulst, F.C. (2007). The generalizability of the Youth Self-Report syndrome structure in 23 societies. Journal of Consulting and Clinical Psychology, 75(5), 729-738. Jaddoe, V.W.V.K., Bakker, R., Duijn, C.M. van, Heijden, A.J. van der, Lindemans, J., Mackenbach, J.P., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2007). The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. European Journal of Epidemiology, 22(1), 917-923. Kallen, V.L., Ferdinand, R.F. & Tulen, J.H.M. (2007). Early attention processes and anxiety in children. Perceptual and Motor Skills, 104(1), 221-235. Lang, N.D.J. van, Tulen, J.H.M., Kallen, V.L., Rosbergen, B, Dieleman, G. & Ferdinand, R.F. (2007). Autonomic reactivity in clinically referred children attention-deficit/hyperactivity disorder versus anxiety disorder. European Child & Adolescent Psychiatry, 16(2), 71-78. Lang, N.D.J. van, Ferdinand, R.F. & Verhulst, F.C. (2007). Predictors of future depression in early and late adolescence. Journal of Affective Disorders, 97(1-3), 137-144. Lier, P.A.C. van, Ende, J. van der, Koot, HM & Verhulst, F.C. (2007). Which better predicts conduct problems? The relationship of trajectories of conduct problems with ODD and ADHD symptoms from childhood into adolescence. Journal of Child Psychology and Psychiatry, 48(6), 601-608. Naarding, P., Tiemeier, H.W., Breteler, M.M.B., Schoevers, R.A., Jonker, C., Koudstaal, P.J. & Beekman, ATF (2007). Clinically defined vascular depression in the general population. Psychological Medicine, 37(3), 383-392. Nijs, P.F.A. de, Lier, P.A.C. van, Verhulst, F.C. & Ferdinand, R.F. (2007). Classes of disruptive Behavior problems in referred adolescents. Psychopathology, 40(6), 440-445. Nijs, P.F.A. de, Ferdinand, R.F. & Verhulst, F.C. (2007). No hyperactive-impulsive subtype in teacher-rated attentiondeficit/hyperactivity problems. European Child & Adolescent Psychiatry, 16(1), 25-32. Oldehinkel, A.J., Rosmalen, J.G.M., Veenstra, R., Dijkstra, JK & Ormel, J. (2007). Being admired or being liked: Classroom social status and depressive problems in early adolescent girls and boys. Journal of Abnormal Child Psychology, 35(3), 417-427. Oldehinkel, A.J., Hartman, C.A., Ferdinand, R.F., Verhulst, F.C. & Ormel, J. (2007). Effortful control as modifier of the association between negative emotionality and adolescents' mental health problems. Development & Psychopathology, 19(2), 523-539.

Oort, F.V.A. van, Joung, I.M.A., Mackenbach, J.P., Verhulst, F.C., Bengi-Arslan, L, Crijnen, A.A.M. & Ende, J. van der (2007). Development of ethnic disparities in internalizing and externalizing problems from adolescence into young adulthood. Journal of Child Psychology and Psychiatry, 48(2), 176-184. Oort, F.V.A. van, Ende, J. van der, Crijnen, A.A.M., Verhulst, F.C., Mackenbach, J.P. & Joung, I.M.A. (2007). Ethnic disparities in problem behaviour in adolescence contribute to ethnic disparities in social class in adulthood. Social Psychiatry and Psychiatric Epidemiology, 42(1), 50-56. Polderman, J.C., Derks, EM, Hudziak, JJ, Verhulst, F.C., Posthuma, D & Boomsma, D.I. (2007). Across the continuum of attention skills: a twin study of the SWAN ADHD rating scale. Journal of Child Psychology and Psychiatry, 48(11), 10801087. Polderman, J.C., Posthuma, D, Sonneville, L.M.J. de, Stins, J.F., Verhulst, F.C. & Boomsma, D.I. (2007). Genetic analyses of the stability of executive functioning during childhood. Biological Psychology, 76(1-2), 11-20. Reichart, C.G., Ende, J. van der, Hillegers, M.H.J., Wals, M., Bongers, I.L., Nolen, W.A., Ormel, J. & Verhulst, F.C. (2007). Perceived parental rearing of bipolar offspring. Acta Psychiatrica Scandinavica, 115(1), 21-28. Reichart, C.G., Ende, J. van der, Wals, M., Hillegers, M.H.J., Nolen, W.A., Ormel, J. & Verhulst, F.C. (2007). Social functioning of bipolar offspring. Journal of Affective Disorders, 98(3), 207-213. Reichart, C.G., Wals, M. & Hillegers, M.H.J. (2007). Children of parents with bipolar disorder. Tijdschrift voor Psychiatrie, 49(3), 179-188. Rescorla, L, Achenbach, T.M., Ivanova, MY, Dumenci, L, Almqvist, F, Bilenberg, N, Bird, H, Broberg, A, Dobrean, A, Dopfner, M, Erol, N., Forns, M, Hannesdottir, H, Kanbayashi, Y, Lambert, M.C., Leung, P, Minaei, A, Mulatu, MS, Novik, TS, Oh, KJ, Roussos, A, Sawyer, M, Simsek, Z, Steinhausen, HC, Weintraub, S, Metzke, CW, Wolanczyk, T, Zilber, N., Zukauskiene, R & Verhulst, F. (2007). Epidemiological comparisons of problems and positive qualities reported by adolescents in 24 countries. Journal of Consulting and Clinical Psychology, 75(2), 351-358. Rescorla, LA, Achenbach, T.M., Ginzburg, S., Ivanova, MY, Dumenci, L, Almqvist, F, Bathiche, M., Bilenberg, N, Bird, H, Domuta, A., Erol, N., Fombonne, E., Fonseca, AC, Frigerio, A, Kanbayashi, Y, Lambert, M.C., Liu, X., Leung, P, Minaei, A, Roussos, A, Simsek, Z, Weintraub, S, Weisz, J., Wolanczyk, T, Zubrick, S.R., Zukauskiene, R & Verhulst, F.C. (2007). Consistency of teacher-reported problems for students in 21 countries. School Psychology Review, 36(1), 91-110. Roza, S.J., Verburg, B.O., Jaddoe, V.W.V., Hofman, A., Mackenbach, J.P., Steegers, E.A.P., Witteman, J.C.M., Verhulst, F.C. & Tiemeier, H.W. (2007). Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study. European Journal of Neuroscience, 25(3), 611-617. Ruiter, K.P. de, Dekker, M.C., Verhulst, F.C. & Koot, HM (2007). Developmental course of psychopathology in youths with and without intellectual disabilities. Journal of Child Psychology and Psychiatry, 48(5), 498-507. Slottje, PL, Twisk, J.W.R., Smidt, N., Huizink, A.C., Witteveen, A.B., Mechelen, W. van & Smid, T. (2007). Health-related quality of life of firefighters and police officers 8.5 years after the air disaster in Amsterdam. Quality of Life Research, 16(2), 239-252. Sondeijker, F.E.P.L., Ferdinand, R.F., Oldehinkel, A.J., Veenstra, R., Tiemeier, H.W., Ormel, J. & Verhulst, F.C. (2007). Disruptive behaviors and HPA-axis activity in young adolescent boys and girls from the general population. Journal of Psychiatric Research, 41(7), 570-578. Spijkerboer, A.W., Helbing, W.A., Bogers, A.J.J.C., Domburg, R.T. van, Verhulst, F.C. & Utens, E.M.W.J. (2007). Longterm psychological distress, and styles of coping, in parents of children and adolescents who underwent invasive treatment for congenital cardiac disease. Cardiology in the Young, 17(6), 638-645. Taffe, JR, Gray, KM, Einfeld, SL, Dekker, M.C., Koot, HM, Emerson, E, Koskentausta, T & Tonge, B.J. (2007). Short form of the Developmental Behaviour Checklist. American Journal on Mental Retardation, 112(1), 31-39. Tick, N.T., Ende, J. van der & Verhulst, F.C. (2007). Twenty-year trends in emotional and behavioral problems in Dutch children in a changing society. Acta Psychiatrica Scandinavica, 116(6), 473-482. Tick, N.T., Ende, J. van der, Koot, HM & Verhulst, F.C. (2007). 14-year changes in emotional and behavioral problems of very young Dutch children. Journal of the American Academy Child Adolescent Psychiatry, 46(10), 1333-1340. Troe, J.W.M., Raat, H., Jaddoe, V.W.V.K., Hofman, A., Looman, C.W.N., Moll, H.A., Steegers, E.A.P., Verhulst, F.C., Witteman, J.C.M. & Mackenbach, J.P. (2007). Explaining differences in birthweight between ethnic populations. The generation R study. Bjog-An International Journal of Obstetrics and Gynaecology, 1557(1565). Utens, E.M.W.J. (2007). Partnerrelatietherapie bij huiselijk geweld. Psychopraxis, 5, 181-224.

Veenstra, R., Lindenberg, S, Zijlstra, BJH, Winter, A.F. de, Verhulst, F.C. & Ormel, J. (2007). The dyadic nature of bullying and victimization: Testing a dual-perspective theory. Child Development, 78(6), 1843-1854. Verheij, F., Verhulst, F.C. & Ferdinand, R.F. (2007). Kinder- en jeugdpsychiaterie. Tijdschrift voor Psychiatrie, 49(7), 439441. Verheij, F. (2007). Waarom krijgen juist pubermeisjes eetstoornissen? Monitor, 36, 18. Vuijk, P., Lier, P.A.C. van, Crijnen, A.A.M. & Huizink, A.C. (2007). Testing sex-specific pathways from peer victimization to anxiety and depression in early adolescents through a randomized intervention trial. Journal of Affective Disorders, 100(13), 221-226. Witteveen, A.B., Bramsen, I., Twisk, J.W.R., Huizink, A.C., Slottje, P., Smid, T. & Ploeg, H.M. van der (2007). Psychological distress of rescue workers eight and one-half years after professional involvement in the Amsterdam air disaster. Journal of Nervous and Mental Disease, 195(1), 31-40. Zwaanswijk, M., Ende, J. van der, Verhaak, P.F.M., Bensing, J.M. & Verhulst, F.C. (2007). The different stages and factors involved in the process leading to the use of adolescent mental health services. Clinical Child Psychology and Psychiatry, 12(4), 567-582. Part of book - abstract Lier, M.H.M. van, Verheij, F., Verhulst, F.C. & Ferdinand, R.F. (2007). Voedings- en eetstoornissen bij jonge kinderen. In F. Verheij, F.C. Verhulst & R.F. Ferdinand (Eds.), Kinder- en jeugdspychiatrie. Behandeling en begeleiding (pp. 162-179). Assen: Koninklijke van Grocum. Verheij, F. (2007). Binge eating disorder. In F. Verheij, F.C. Verhulst & R.F. Ferdinand (Eds.), Kinder- en jeugdspychiatrie. Behandeling en begeleiding (pp. 226-228). Assen: Koninklijke van Gorcum. Verheij, F. (2007). Anorexia nervosa en andere eetstoornissen met magerte of vermagering. In F. Verheij, F.C. Verhulst & R.F. Ferdinand (Eds.), Kinder- en jeugdspychiatrie. Behandeling en begeleiding (pp. 180-212). Assen: Koninlklijke van Gorcum. Verheij, F. (2007). Boulimia nervosa. In F. Verheij, F.C. Verhulst & R.F. Ferdinand (Eds.), Kinder- en jeugdspychiatrie. Behandeling en begeleiding (pp. 213-225). Assen: Koninklijke van Gorcum. Verhulst, F.C. & Verheij, F. (2007). Continuiteit en discontinuiteit van psychopathologi in de kindertijd en de adolescentie. In E.H.M. Eurelings-Bontekoe, R. Verheul & W.M. Snellen (Eds.), Handboek persoonlijkheidspathologie (pp. 49-61). Houten: Bohn Stafleu van Loghum. Book editorship Verheij, F., Verhulst, F.C. & Ferdinand, R.F. (Eds.). (2007). Kinder- en jeugdspychiatrie. Behandeling en begeleiding. Assen: Koninklijke van Gorcum. Other output Verheij, F. (2007). Methodiekontwikkeling, hulpmiddel om te veranderen. Methodiekontwikkeling, hulpmiddel om te veranderen: Utrecht.

EMC NIHES-04-56-01 - The dynamics of emotions and adaptation of (future) chronic patients Programme design in brief This programme investigates the emotional reactions (including the affective, physiological, cognitive and behavioural aspects in chronic patients), to disease and treatment, and the coping with these reactions. The principal medical problems addressed by our research can be related to two fields: `chronic pain' and `clinical genetics'. Other medical areas in our studies concern: cardio-vascular diseases, quality of life, psychotherapy, reproductive medicine, and transplantation. The programme includes clinimetrics and psychometrics, model-fitting and the development of prognostics. The programme is part of NIHES and carried out with clinical departments of the Erasmus MC, the Pain Expertise Centre Rotterdam and the Expertise Centre for Palliative Care Rotterdam Key figures Department

SP1

SP2

SP3

SP4

SPtot

medical psychology & psychotherapy

2,01

2,25

2,55

2,45

9,26

Total

2,01

2,25

2,55

2,45

9,26

T1

T2

2

T3

0

Ttot

0

IS

2

FS

47

OP

2

Ptot

15

Theses Kranenburg, L.W. (2007, juni 27). Psychological and ethical aspects of living kidney donation. EUR (197 pag.). Prom./coprom.: Prof.Dr. J. Passchier & Prof.Dr. W. Weimar. Thunnissen, M.M. (2007, januari 17). Long-term prognosis and aftercare in short-term inpatient psychotherapy of personality disorders - A randomised clinical trial of two methods of aftercare. EUR (128 pag.). Prom./coprom.: Prof.Dr. R.W. Trijsburg, W. van Tilburg & R. Verheul. Article/Letter to the editor Akker, E. van den, Puiman, P.J., Groen, M.M., Timman, R., Jongejan, M. & Trijsburg, R.W. (2007). Follow-up study of a cognitive behavioral therapy program for overweight and obese children. International Journal of Obesity, 31, S116-S116. Akker, E.L.T. van den, Puiman, P.J., Groen, M., Timman, R., Jongejan, M.T. & Trijsburg, R.W. (2007). A cognitive behavioral therapy program for overweight children. Journal of Pediatrics, 151(3), 280-283. Bakker, T.J.E.M., Duivenvoorden, H.J., Lee, J. van der & Ribbe, M.W. (2007). De relatie van psychiatrische functiestoornissen met cognitie, activiteiten dagelijks leven (ADL) en biografische gegevens. Tijdschrift voor Gerontologie en Geriatrie, 38(2), 77-87. Bartak, A, Soeteman, D.I., Verheul, R. & Busschbach, J.J.V. van (2007). Strengthening the status of psychotherapy for personality disorders: An integrated perspective on effects and costs. Canadian Journal of Psychiatry, 52(12), 803-810. Bonke, B. (2007). Redactioneel. Tijdschrift voor Medisch Onderwijs, 26(5), 209-211. Borsboom, G.J.J.M., Korfage, I.J., Essink-Bot, M.L. & Duivenvoorden, H.J. (2007). The structural equation modeling technique did not show a response shift, contrary to the results of the then test and the individualized approaches. Journal of Clinical Epidemiology, 60(4), 426-427. Both, H., Essink-Bot, M.L., Busschbach, J. van & Nijsten, T. (2007). Critical review of generic and dermatology-specific health-related quality of life instruments. Journal of Investigative Dermatology, 127(12), 2726-2739. Bresser, P.J.C., Seynaeve, C., Gool, A.R. van, Niermeijer, M.F., Duivenvoorden, H.J., Dooren, S. van, Geel, A.N. van, Menke-Pluymers, M.B.E., Klijn, J.G.M. & Tibben, A. (2007). The course of distress in women at increased risk of breast and ovarian cancer due to an (identified) genetic susceptibility who opt for prophylactic mastectomy and/or salpingooophorectomy. European Journal of Cancer, 43(1), 95-103. Bresser, P.J.C., Gool, A.R. van, Seynaeve, C., Duivenvoorden, H.J., Niermeijer, M.F., Geel, A.N. van, Menke, M, Klijn, J.G.M. & Tibben, A. (2007). Who is prone to high levels of distress after prophylactic mastectomy and/or salpingoovariectomy? Annals of Oncology, 18(10), 1641-1645. Busschbach, J.J. van & Hutschemaekers, G. (2007). Psychotherapie: goede of slechte zaak? Uitgeschreven betoog naar aanleiding van debate tussen Jan van Busschbach met Giel Hutschemaekers, tijdens het National Psychotherapie debat, 13 juni 2007, Beatrix Theater Utrecht. Tijdschrift voor Psychotherapie, 33(5), 352-355. Busschbach, J.J. van (2007). QUALY is ethiek. Nieuwsbrief, 14(1), 9-11. Couturier, E.G.M., Busschbach, J.J. van, Merelle, S., Passchier, J. & Bokhorst, J. van (2007). Large scale screening and subsequent effects of optimal migraine treatment at work. Cephalalgia, 27(6), 693-694.

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Darlington - Molkenboer, A.S., Dippel, D.W.J., Ribbers, G.M., Balen, R. van, Passchier, J. & Busschbach, J.J.V. van (2007). Coping strategies as determinants of quality of life in stroke patients: A longitudinal study. Cerebrovascular Diseases, 23(5-6), 401-407. Dooren, S. van, Oldenmenger, W.H., Echteld, M.A., Passchier, J., Groeneweg, J.G. & Rijt, C.C.D. van der (2007). Kankergerelateerde vermoeidheid en multidimensionele aspecten tijdens de palliatieve fase van het ziektebeloop. Nederlands Tijdschrift voor Palliatieve Zorg, 8(1), 1-6. Echteld, M.A., Passchier, J., Teunissen, S, Claessen, S, Wit, R. de & Rijt, C.C.D. van der (2007). Multidimensional fatigue and its correlates in hospitalised advanced cancer patients. European Journal of Cancer, 43(6), 1030-1036. Erdman, R.A.M. (2007). Herinneringen aan Wim Trijsburg (5). Wim Trijsburg als psychotherapeut (1). Tijdschrift voor Psychotherapie, 33, 454-456. Festen, D.A.M., Toorenenbergen, A. van, Duivenvoorden, H.J. & Hokken-Koelega, A.C.S. (2007). Adiponectin levels in prepubertal children with Prader-Willi syndrome before and during growth hormone therapy. Journal of Clinical Endocrinology and Metabolism, 92(4), 1549-1554. Festen, D.A.M., Wevers, M., Weerd, A.W. de, Bossche, R.A.S. van den, Duivenvoorden, H.J., Otten, B.J., Wit, J.M. & Hokken-Koelega, A.C.S. (2007). Psychomotor development in infants with Prader-Willi syndrome and associations with sleep-related breathing disorders. Pediatric Research, 62(2), 221-224. Festen, D.A.M., Visser, T.J., Otten, B.J., Wit, J.M., Duivenvoorden, H.J. & Hokken-Koelega, A.C.S. (2007). Thyroid hormone levels in children with Prader-Willi syndrome before and during growth hormone treatment. Clinical Endocrinology, 67(3), 449-456. Gestel, Y.R.B.M. van, Pedersen, S.S., Sande, M van de, Jaegere, P.P.T. de, Serruys, P.W.J.C., Erdman, R.A.M. & Domburg, R.T. van (2007). Type-D personality and depressive symptoms predict anxiety 12 months post-percutaneous coronary intervention. Journal of Affective Disorders, 103, 197-203. Gutteling, J.J., Man, R.A. de, Busschbach, J.J. van & Darlington, A.S. (2007). Health related quality of life and psychological correlates in patients listed for liver transplantation. Hepatology International, 1(4), 437-443. Gutteling, J.J., Man, R.A. de, Busschbach, J.J.V. van & Darlington - Molkenboer, A.S. (2007). Overview of research on health-related quality of life in patients with chronic liver disease. Netherlands Journal of Medicine, 65(7), 227-234. Harder, H., Gool, A.R. van, Duivenvoorden, H.J., Cornelissen, J.J., Eijkenboom, W.M.H., Barge, R.M.Y. & Bent, M.J. van den (2007). Case-referent comparison of cognitive functions in patients receiving haematopoietic stem-cell transplantation for haematological malignancies: Two-year follow-up results. European Journal of Cancer, 43(14), 2052-2059. Heijnen, E.M.E.W., Eijkemans, M.J.C., Klerk, C. de, Polinder, S., Beckers, N.G.M., Klinkert, E.R., Broekmans, F.J.M., Passchier, J., Velde, E.R. te & Fauser, B.C.J.M. (2007). A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial. Lancet (UK), 369(9563), 743-749. Hilhorst, M.T., Kranenburg, L.W. & Busschbach, J.J. van (2007). Should health care professionals encourage living kidney donation? Medicine, Health Care and Philosophy, 10(1), 81-90. Kaat, L.D., Boon, A.J.W., Kamphorst, W., Ravid, R., Duivenvoorden, H.J. & Swieten, J.C. van (2007). Frontal presentation in progressive supranuclear palsy. Neurology, 69(8), 723-729. Klerk, C. de, Macklon, N.S., Heijnen, E.M.E.W., Eijkemans, M.J.C., Fauser, B.C.J.M., Passchier, J. & Hunfeld, J.A.M. (2007). The psychological impact of IVF failure after two or more cycles of IVF with a mild versus standard treatment strategy. Human Reproduction, 22(9), 2554-2558. Klerk, M. de, Zuidema, W.C., Kranenburg, L., Ijzermans, J.N.M. & Weimar, W. (2007). Justification for anonymity in a kidney exchange program. American Journal of Transplantation, 7, 563-563. Klerk, M.A. de & Kranenburg, L.W. (2007). Drie jaar cross-over transplantatieprogramma. Een goed alternatief als direct doneren niet mogelijk is. Wisselwerking (Hoevelaken), 16. Klerk, M.A. de & Kranenburg, L.W. (2007). Drie jaar cross-over transplantatieprogramma. Een goed alternatief als direct doneren niet mogelijk is. Wisselwerking (Hoevelaken), 16. Kok, E., Bohnen, A.M., Groeneveld, J., Busschbach, J.J. van, Blanker, M.H. & Bosch, R. van den (2007). Veranderingen in ziektespecifieke en generieke kwaliteit van leven na veranderde plasklachten bij oudere mannen. Huisarts en Wetenschap, 50(6), 248-252. Kok, E.T., Groeneveld, F.P.M.J., Busschbach, J.J.V. van, Hop, W.C.J., Bosch, J.L.H.R., Thomas, S. & Bohnen, A.M. (2007). Influence of coping styles on quality of life in men with new and increasing lower urinary tract symptoms. Urologia Internationalis, 79(3), 226-230.

Korenromp, MJ, Page-Christiaens, GCML, Bout, J., Mulder, E.J.H., Hunfeld, J.A.M., Potters, CMAA, Erwich, JJHM, Binsbergen, CJM van, Brons, J.T.J., Beekhuis, JR, Omtzigt, AWJ & Visser, G.H.A. (2007). A prospective study on parental coping 4 months after termination of pregnancy for fetal anomalies. Prenatal Diagnosis, 27(8), 709-716. Kranenburg, L., Zuidema, W., Vanderkroft, P, Duivenvoorden, H., Weimar, W., Passchier, J., Hilhorst, M., Klerk, M., Ijzermans, J.N.M. & Busschbach, J. van (2007). The implementation of a kidney exchange program does not induce a need for additional psychosocial support. Transplant International, 20(5), 432-439. Kranenburg, L., Zuidema, W., Weimar, W., Hilhorst, M., Ijzermans, J.N.M., Passchier, J. & Busschbach, J. van (2007). Why potential donors refuse living kidney donation. American Journal of Transplantation, 7, 268-268. Kranenburg, L.W., Zuidema, W.C., Weimar, W., Hilhorst, M.T., IJzermans, J.N.M., Passchier, J. & Busschbach, J.J.V. van (2007). Psychological barriers for living kidney donation: How to inform the potential donors? Transplantation, 84(8), 965971. Laan, P. van der, Busschbach, J.J. van & Bijleveld, C. (2007). Experimetele criminologie en criminologische experimenten. Tijdschrift voor Criminologie, 49(1), 1-11. Merelle, S.Y.M., Merelle, S., Passchier, J., Sorbi, M.J. & Doornen, L.J.P. van (2007). Clinical effects of a behavioral training aimed at migraine prevention and delivered by migraine patient trainers. Cephalalgia, 27(6), 728-728. Oostrom, I. van, Meijers-Heijboer, E.J., Duivenvoorden, H.J., Brocker-Vriends, AHJT, Asperen, C.J. van, Sijmons, RH, Seynaeve, C., Gool, A.R. van, Klijn, J.G.M., Riedijk, S.R., Dooren, S. van & Tibben, A. (2007). A prospective study of the impact of genetic susceptibility testing for BRCA1/2 or HNPCC on family relationships. Psycho-Oncology, 16(4), 320-328. Oostrom, I. van, Meijers-Heijboer, E.J., Duivenvoorden, H.J., Brocker-Vriends, AHJT, Asperen, C.J. van, Sijmons, RH, Seynaeve, C., Gool, A.R. van, Klijn, J.G.M. & Tibben, A. (2007). Comparison of individuals opting for BRCA1/2 or HNPCC genetic susceptibility testing with regard to coping, illness perceptions, illness experiences, family system characteristics and hereditary cancer distress. Patient Education and Counseling, 65(1), 58-68. Oostrom, I. van, Meijers-Heijboer, E.J., Duivenvoorden, H.J., Brocker-Vriends, AHJT, Asperen, C.J. van, Sijmons, RH, Seynaeve, C., Gool, A.R. van, Klijn, J.G.M. & Tibben, A. (2007). Family system characteristics and psychological adjustment to cancer susceptibility genetic testing: a prospective study. Clinical Genetics, 71(1), 35-42. Oostrom, I. van, Meijers-Heijboer, E.J., Duivenvoorden, H.J., Brocker-Vriends, AHJT, Asperen, C.J. van, Sijmons, RH, Seynaeve, C., Gool, A.R. van, Klijn, J.G.M. & Tibben, A. (2007). Prognostic factors for hereditary cancer distress six months after BRCA1/2 or HNPCC genetic susceptibility testing. European Journal of Cancer, 43(1), 71-77. Oostrom, I. van, Meijers-Heijboer, H, Duivenvoorden, H.J., Broecker-Vriends, AHJT, Asperen, C.J. van, Sijmons, RH, Seynaeve, C., Gool, A.R. van, Klijn, J.G.M. & Tibben, A. (2007). The common sense model of self-regulation and psychological adjustment to predictive genetic testing: a prospective study. Psycho-Oncology, 16(12), 1121-1129. Pedersen, S.S., Denollet, J, Ong, A.T.L., Sonnenschein, K, Erdman, R.A.M., Serruys, P.W. & Domburg, R.T. van (2007). Adverse clinical events in patients treated with sirolimus-eluting stents: the impact of Type D personality. European Journal of Cardiovascular Prevention & Rehabilitation, 14(1), 135-140. Pedersen, S.S., Denollet, J, Daemen, J., Sande, M van de, Jaegere, P.P.T. de, Serruys, P.W., Erdman, R.A.M. & Domburg, R.T. van (2007). Fatigue, depressive symptoms, and hopelessness as predictors of adverse clinical events following percutaneous coronary intervention with paclitaxel-eluting stents. Journal of Psychosomatic Research, 62(4), 455-461. Pedersen, S.S., Denollet, J, Ong, A.T.L., Serruys, P.W., Erdman, R.A.M. & Domburg, R.T. van (2007). Impaired health status in type D patients following PCI in the drug-eluting stent era. International Journal of Cardiology, 114(3), 358-365. Pedersen, S.S., Theuns, D.A.M.J., Heemskerk, A.J.Q.M., Erdman, R.A.M. & Jordaens, L.J.L.M. (2007). Type-D personality but not implantable cardioverter-defibrillator indication is associated with impaired health-related quality of life 3 months post-implantation. Europace, 9(8), 675-680. Pedersen, S.S., Daemen, J., Sande, M van de, Sonnenschein, K, Serruys, P.W., Erdman, R.A.M. & Domburg, R.T. van (2007). Type-D personality exerts a stable, adverse effect on vital exhaustion in PCI patients treated with paclitaxel-eluting stents. Journal of Psychosomatic Research, 62(4), 447-453. Pieterse, K., Dooren, S. van, Seynaeve, A.L.B., Bartels, C.C.M., Rijnsburger, A.J., Koning, H.J. de, Klijn, J.G.M., Elderen, T.M.T. van, Tibben, A. & Duivenvoorden, H.J. (2007). Passive coping and psychological distress in women adhering to regular breast cancer surveillance. Psycho-Oncology, 61, 851-858. Plas, S.M. van der, Hansen, B.E., Boer, J.B. de, Stijnen, T., Passchier, J., Man, R.A. de & Schalm, S.W. (2007). Generic and disease-specific health related quality of life of liver patients with various aetiologies: A survey. Quality of Life Research, 16(3), 375-388.

Sandt-Koenderman, W.M.E., Wiegers, J, Wielaert, S.M., Duivenvoorden, H.J. & Ribbers, G.M. (2007). A computerised communication aid in severe aphasia: An exploratory study. Disability & Rehabilitation, 29(22), 1701-1709. Sandt-Koenderman, W.M.E., Wiegers, J, Wielaert, S.M., Duivenvoorden, H.J. & Ribbers, G.M. (2007). High-tech AAC and severe aphasia: candidacy for TouchSpeak (TS). Aphasiology, 21(5), 459-474. Soeteman, D.I., Roijen, L., Verheul, R. & Busschbach, J.J. van (2007). The economic burden of personality disorders. Journal of Mental Health Policy and Economics, 10, 42. Spindler, H, Pedersen, S.S., Serruys, P.W., Erdman, R.A.M. & Domburg, R.T. van (2007). Type-D personality predicts chronic anxiety following percutaneous coronary intervention in the drug-eluting stent era. Journal of Affective Disorders, 99(1-3), 173-179. Stalmeier, PFM, Lamers, L.M., Busschbach, J.J. van & Krabbe, P.F.M. (2007). On the Assessment of Preferences for Health and Duration: Maximal endurable time and better than dead preferences. Medical Care, 45(9), 834-841. Trijsburg, R.W. (2007). Groepspsychotherapie in onderzoek. Groepen, 2, 15-25. Vos, C. de, Verhagen, A., Passchier, J. & Koes, B. (2007). Management of acute neck pain in general practice: a prospective study. British Journal of General Practice, 57(534), 23-28. Vos, P.J., Visser, A.P., Garssen, B, Duivenvoorden, H.J. & Haes, H.C.J.M. (2007). Effectiveness of group psychotherapy compared to social support groups in patients with primary, non-metastatic breast cancer. Journal of Psychosocial Oncology, 25(4), 37-60. Zuidema, W., Kranenburg, L., Erdman, R., De, M Klerk, Hilhorst, M., Ijzermans, J.N.M. & Weimar, W. (2007). Domino paired kidney donation with altruistic donors. American Journal of Transplantation, 7, 561-562. Zuidema, W., Kranenburg, L., Tronchet, N, Hilhorst, M., Erdman, R., Ijzermans, J.N.M. & Weimar, W. (2007). Motivations of altruistic living kidney donors. American Journal of Transplantation, 7, 562-562. Part of book - abstract Andrea, H. & Verheul, R.M. (2007). Categoriale classificatie, epidemiologie en comorbiditeit. In E.H.M. EurelingsBontekoe, R. Verheul & W.M. Snellen (Eds.), Handboek persoonlijksheidspathologie (pp. 75-101). Houten: Bohn Stafleu van Loghum. Bartak, A, Busschbach, J.J. van & Emmelkamp, P.M.G. (2007). Psychotherapie en de moderne wetenschap: de controverse over effectiviteitsstudies bij persoonlijkheidsstoornissen. In R. Verheul & J.H. Kamphuis (Eds.), De toekomst van persoonlijkheidsstoornissen 2007 (pp. 74-87). Houten: Bohn Stafleu van Loghum. Passchier, J. (2007). Qualidade de vida na crianca com cefaleia. In M.A. Arruda & V. Guidetti (Eds.), Cefaleias na Infancia e Adolescencia (pp. 69-73). Sao Paulo, Brazil, Instituto Glia: Ribeirao. Soeteman, D.I. & Busschbach, J.J. van (2007). Beleidsvorming voor psychotherapie: van willekeur tot economische modellen. In R. Verheul & J.H. Kamphuis (Eds.), De toekomst van persoonlijkheidsstoornissen 2007 (pp. 189-200). Houten: Bohn Stafleu van Loghum.

EMC NIHES-05-63-01 - Health care management (theme 3) Programme design in brief This research line focuses on the social, legal and organisational aspects of management of professional knowledge, quality systems, information and communication technology in health care and health care management. The programme aims to translate theories of organisation, management and policy into practical guidelines and recommendations for health care organisations. Case studies are undertaken to gain insight in the dynamics of inter- and intra-organisational networks and in opportunities for network management. Special emphasis is put on the quality and accessibility of health care for ethnic minorities. Finally the programme evaluates effects of new health care legislation Key figures Department

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Theses Fabbricotti, I.N. (2007, februari 08). Zorgen voor Zorgketens Integratie en fragmentatie in de ontwikkeling van zorgketens. EUR (387 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof.Dr. R. Huijsman, Prof.Dr. P.L. Meurs, Prof.Dr. G. de Vries, Prof.Dr. C. Spreeuwenberg & A.J.P. Schrijvers. Helderman, J.K.. Bringing the market back in? EUR (317 pag.). Prom./coprom.: Prof.Dr. T.E.D. van der Grinten & Dr. J. Schaar. Hoek, H (2007, februari 22). Governance & gezondheidszorg. EUR. Prom./coprom.: Prof.Dr. P.L. Meurs & Prof.Dr. R.M. Lapre Uiters, A.H. (2007, november 09). Primary health care use among ethnic minorities in the Netherlands. EUR. Prom./coprom.: Dr. M. Berg & P.P. Groenewegen Wijk, K.P. van (2007, mei 24). The Service Care Chain The influence of service and HRM on the realization of demanddriven care by careorganisations. EUR (248 pag.) (Rotterdam: Erasmus iBMG). Prom./coprom.: Prof.Dr. J.K. van Dijk, Prof.Dr. J. Paauwe, Prof.Dr. R. Huijsman, Prof.Dr. G. de Vries & Dr.Ir. A. van der Wiele. Zuiderent, T. (2007, oktober 25). Standardizing healthcare practices. EUR (189 pag.) (Rotterdam: Erasmus Universiteit). Prom./coprom.: Dr. M. Berg & Dr. R.A. Bal. Article/Letter to the editor Aarts, J.E.C.M., Ash, J. & Berg, M. (2007). Extending the understanding of computerized physician order entry: Implications for professional collaboration workflow and quality of care. International Journal of Medical Informatics, 76S, 4-13. Aarts, J.E.C.M. & Gorman, P. (2007). IT in Health Care: sociotechnical Approaches " To Err is System". International Journal of Medical Informatics, 76S, S1-S3. Aarts, J.E.C.M. (2007). Letter to the editor. Methods of Information in Medicine, 1. Bal, R.A. (2007). De bevlogen onderzoeker. Kwaliteit in beeld, 17(2), 6-7. Bal, R.A. & Pijnenborg, L. (2007). SNELLER BETER PIJLER 3 Een tussenstand. ZEmagazine, 1(2), 28-33. Bijlenga, D., Birnie, E., Mol, B.W.J. & Bonsel, G.J. (2007). When outcome is a balance: methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term. BioMed Central, 7, 1-4. Boers, K.E., Bijlenga, D., Mol, B.W.J., Cessie, S. le, Birnie, E., Pampus, M.G. van, Stigter, R.H., Bloemenkamp, K.W.M., Meir, C.A. van, Post, JAM Van der, Bekedam, D.J., Ribbert, L.S.M., Drogtrop, A.P., Salm, P.C.M. van der, Huisjes, A.J.M., Willekes, C., Roumen, F.J.M.E., Scheepers, H.C.J., Boer, K de, Duvekot, J.J., Thornton, J.G. & Scherjon, SA (2007). Disproportionate intrauterine growth intervention trial at term: DIGITAT. BMC Pregnancy and Childbirth, 7, 1-12. Boot, HJ, Wallenburg, I., Melker, H.E. de, Mangen, M.M., Gerritsen, A.A.M., Maas, N.A., Berkhof, J, Meijer, C.J.L.M. & Kimman, T.G. (2007). Assessing the introduction of universal human papillomavirus vaccination for preadolescent girls in The Netherlands. Vaccine, 25, 6245-6256. Christiaans, I., Dijksman, L.M. & Birnie, E. (2007). ESCAPE-HCM study: Evaluation of SCreening of Asymptomatic patients with hypertrophic CardioMyopathy. Netherlands Heart Journal, 15(6), 216-220.

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Cramm, J.M., Finkenflugel, H.J.M. & Brinkman, A (2007). Palliatieve dagzorg; een nieuw zorgconcept in Nederland. Nederlands Tijdschrift voor Palliatieve Zorg, 8(2), 43-46. Dijk, J.K. van, Paauwe, P. & Wijk, K.P. van (2007). Arbeidsmarkt, personeel en innovatie. ZEmagazine, 03, 8-12. Dirks, M., Niessen, L.W., Huijsman, R., Wijngaarden, J.D.H. van, Minkman, M.M.N., Franke, C.L., Oostenbrugge, RJ van, Koudstaal, P.J. & Dippel, D.W.J. (2007). Promoting acute thrombolysis for ischaemic stroke (PRACTISE). International Journal of Stroke, 2, 151-159. Essink-Bot, M.L., Stuifbergen, M.C., Meerding, W.J., Looman, C.W.N. & Bonsel, G.J. (2007). Individual differences in the use of the response scale determine valuations of hypothetical health states: an empirical study. Bmc Health Services Research, 7. Finkenflugel, H.J.M. (2007). Changing roles of physical therapists in community-based rehabilitation. Physical Therapy, 117(3), 74-75. Finkenflugel, H.J.M. (2007). In 2015 is de WMO alweer verleden tijd. Zorg + Welzijn, 13, 24. Glind, I.M. van de, Roode, S. & Goossensen, M.A. (2007). Do Patients in hospitals benefit from single rooms? A literature review. Health Policy, 84, 153-161. Goossensen, M.A., Zijlstra, P & Koopmanschap, M.A. (2007). Measuring shared decision making processes in psychiatry: Skills versus patient satisfaction. Patient Education and Counseling, 67, 50-56. Goossensen, M.A., Glind, G. van de, Carpentier, P.J., Wijsen, R.M.A., Duin, D. van & Kooij, S. (2007). Herkenning en intramurale behandeling van ADHD in de verslavingszorg. Verslaving, 3(4), 18-30. Goossensen, M.A. (2007). Veranderen en vernieuwen in de verslavingszorg (1): over blauwe en witte mensen. Verslaving, 3, 68-70. Goossensen, M.A. (2007). Veranderen en vernieuwen in de verslavingszorg (2): over kwaliteit van aandacht. Verslaving, 3, 77-78. Goossensen, M.A. (2007). Veranderen en vernieuwen in de verslavingszorg (3): de verborgen kracht van mentale modellen. Verslaving, 3(4), 64-65. Groenewoud, AS, Otten, J.D.M., Fracheboud, J., Draisma, G., Ineveld, B.M. van, Holland, R., Verbeek, A.L.M. & Koning, H.J. de (2007). Cost-effectiveness of different reading and referral strategies in mammography screeing in the Netherlands. Breast Cancer Research and Treatment, 102(2), 211-218. Hout, E. van, Scheer, W.K. van der & Putters, K. (2007). Managers en professionals in de zorg: over verschuivende verantwoordelijkheden en hybridisering. Bestuurskunde, 16(4), 16-24. Huijsman, R. (2007). Borg innovatie. Kwaliteit in beeld, 4, 12-12. Huijsman, R. (2007). Care op kruispunt. Kwaliteit in beeld, 3, 6-6. Huijsman, R. (2007). Het pand als bedrijfsinstrument Het totale serviceconcept van de maatchappelijk zorgondernemer. ZM Magazine, 23(10), 4-8. Huijsman, R. & Pol, B. (2007). In het verpleeghuis is het veilig Ouderen huiverig voor zelfstandige groepswoningen. ZorgVisie (Maarssen), 8, 14-16. Huijsman, R. (2007). Management en organisatie in de gezondheidszorg. Kwaliteit in beeld, 4, 17-18. Huijsman, R. (2007). Module geintegreerde eerstelijnszorg: expliciteren en contracteren van prestaties. LVG Nieuws, 3, 22-23. Huijsman, R. (2007). Ruimte voor bevlogen professionals. Kwaliteit in beeld, 2, 9-9. Huijsman, R. (2007). Toezicht: laveren tussen kunde en kitsch. Kwaliteit in beeld, 1, 11-11. Huijsman, R. (2007). Zorgbouw als opbrengstengenerator. Kwaliteit in beeld, 5, 7-7. Jansen, J.W.M., Wijngaarden, J.D.H. van & Bal, R.A. (2007). Leren verbeteren- verbeterd leren Leren in een quality collaborative in Nederlandse ziekenhuizen. M en O, 6, 48-64. Minkman, M., Ahaus, K. & Huijsman, R. (2007). Performance inprovement based on integrated quality management models: what evidence do we have? A systematic literature review. International Journal for Quality in Health Care, 19(2), 90-104.

Mul, M. de & Berg, M. (2007). Completeness of medical records in emergency trauma care and an IT-based strategy for improvement. Medical Informatics and the Internet in Medicine, 32, 157-167. Mul, M. de, Bont, A.A. de & Berg, M. (2007). It-Supported skill-mix change and standardisation in integrated eyecare: lessons from two screening projects in The Netherlands. International Journal of Integrated Care, 7, 1-10. Nas, W.S.C, Stege, H.A. van der, Jedeloo, S. & Staa, A.L. van (2007). Een rooskleurig beeld: Kwaliteit van leven van jongeren met chronische aandoeningen onderzocht in "Op Eigen Benen Verder". Verpleegkunde, 22(4), 203-203. Pickard, A.S., Kohlmann, T., Janssen, M.F., Bonsel, G.J. & Cella, D. (2007). Evaluating equivalency between response systems. Medical Care, 45(9), 812-819. Scheer, W.K. van der (2007). IS THE NEW HEALTH-CARE EXECUTIVE AN ENTREPRENEUR. Public Management Review, 9(1), 49-65. Scholten, G.R.M. & Jacques, D.R. (2007). Onzichtbaar zorgmanagement. M en O, 2, 160-170. Schuppen, M.T. van, Finkenflugel, H.J.M. & Gardenbroek, R. (2007). ANTICONCEPTIEZORG in de eerstelijns praktijk? Tijdschrift voor Verloskundigen, 32(2), 13-16. Staa, A.L. van (2007). Een volwassen leven met Congenitale Ano-Rectale Misvormingen (CARM) tot tell or not to tell. Verpleegkunde, 22(4), 201-201. Staa, A.L. van (2007). Jongeren doen zorgonderzoek in de disco. Mediator, 18, 30-32. Staa, A.L. van (2007). Observaties van jongeren met een chronische aandoening op de polikliniek: van toeschouwer naar hoofdpersoon. Verpleegkunde, 22(4), 202-202. Staa, A.L. van, Kuijper, M., Jedeloo, S. & Latou, J.M. (2007). Participatie van jongeren in de spreekkamer Hoe kunnen kinderverpleegkundigen jongeren met chronische aandoeningen activeren? Kinderverpleging, 13, 10-13. Steinbusch, P.J.M., Oostenbrink, J.B., Zuurbier, J.J. & Schaepkens, F.F.J.M. (2007). The risk of upcoding in casemix systems: A comparative study. Health Policy, 81, 289-299. Steuten, L.., Lemmens, K.M.M. & Vrijhoef, B. (2007). Health technology assessment of asthma disease management programs. Current Opinion in Allergy and Clinical Immunology, 7, 242-248. Stoopendaal, A.M.V. (2007). Afstand en nabijheid, een reactie. Vibes, 8. Stoopendaal, A.M.V. & Krober, H. (2007). Wie presentie zaait zal presentie oogsten. ZM Magazine, 23, 2-5. Tan, S.S., Groot, C.A. de, Huijgens, P.C. & Fibbe, W.E. (2007). Stem cell transplantation in Europe: trends and prospects. European Journal of Cancer, 43, 2359-2365. Tielen, M., Staa, A.L. van, Jedeloo, S. & Weimar, W. (2007). Q-methodology to identify young renal transplant recipients at risk for non-compliance. Transplantationsmedizin, 19, 61-62. Valentine, N.B., Bonsel, G.J. & Murray, C.J.L. (2007). Measuring quality of health care from the user's perspective in 41 countries: psychometric properties of WHO's questions on health systems responsiveness. Quality of Life Research, 16, 1107-1125. Vissers, J.M.H., Adan, IJ.B.F. & Dellaert, N.P. (2007). Developing a platform for comparison of hospital admission systems: an illustration. European Journal of Operational Research, 3, 1290-1301. Vissers, J.M.H., Roosenschoon, B.J., Eijk, J. van der & Veen, H. de (2007). Patientendoorstroming in een GGZ-instelling: een logistieke benadering. ZM Magazine, 3, 12-16. Vissers, J.M.H. (2007). Zorglogistiek en Operations Research Het nut van modellen. ZEmagazine, 2, 18-23. Vries, G. de (2007). Normering als instrument voor processturing. Meet- en regeltechniek in de zorgsector. M en O, 2, 2235. Vries, G. de (2007). Zorglogistiek definitief op de kaart. Na dertig jaar langzaam uit de kinderschoenen. ZEmagazine, 2, 813. Vries, J. de, Commandeur, H. & Huijsman, R. (2007). Management en Organisatie in de gezondheidszorg. M en O, 61(2), 5-21. Wijk, K.P. van (2007). Recentie van "The Oxford Handbook of Human Resource Management". ZEmagazine, 03, 44-44.

Wijngaarden, J.D.H. van, Bont, A.A. de & Huijsman, R. (2007). Learning to cross boundaries: The integration of a health network to deliver seamless care. Health Policy, 79(2-3), 203-213. Zijlstra, P. & Goossensen, M.A. (2007). Shared Decision Making in de psychiatrie. TSG, 2(85), 92-97. Zuiderent, T. (2007). Preventing Implementation: Exploring Interventions with Standardization in Healthcare. Science as Culture, 16(3), 311-329. Zuiderent, T. & Jensen, C.B. (2007). Editorial Introduction: Unpacking 'Intervention' in Science and Technology Studies. Science as Culture, 16(3), 227-235. Part of book - abstract Goossensen, M.A., Arts, K. & Beltman, M.A.C. (2007). 'Mij mankeert niks'. In Zorgprogramma Korsakov in het verpleeghuis. Rotterdam: Korsakov Kenniscentrum. Huijsman, R. (2007). Rijkere perspectieven op uw zorggebouw Het pand als bedrijfsinstrument in het serviceconcept van de maatschappelijk zorgondernemer. In AU! Bouwen aan de architectuur van de zorg (pp. 118). Utrecht: College bouw zorginstellingen. Scholten, G.R.M., Wijngaarden, J.D.H. van & Wijk, K.P. van (2007). Zorgmanagers en hun gereedschapskist de toepassing van de Swot in de gezondheidszorg. In J de Vries, H Commandeur & R Prof.dr. Huijsman (Eds.), Management en Organisatie (pp. 146). Deventer: Kluwer. Staa, A.L. van, Jedeloo, S., Kuijper, M. & Latour, J.M. (2007). Op Eigen Benen. Jongeren met chronische aandoeningen: wat willen en kunnen zij in de zorg? In Bessensap (pp. 8). NWO. Stoopendaal, A.M.V. & Kroger, H. (2007). De aanwezige professional. In Lef en Liefde in de Zorg: Nieuwe inpulsen voor het werk van professionals en managers in de zorg (pp. 47). Rotterdam: Zorgpodium. Vries, J. de, Commandeur, H. & Huijsman, R. (2007). Overzicht en Reflectie. In J de Vries, H Commandeur & R Prof.dr. Huijsman (Eds.), Management en Organisatie (pp. 146). Deventer: Kluwer. Book review Jansen, J.W.M. (2007). Implementatie: effectieve verbetering van de patientenzorg [Bespreking van het boek Implementatie: effectieve verbetering van de patientenzorg]. Kwaliteit in beeld, 23-23. Jansen, J.W.M., Akkersdijk, H., Waegemaekers, H. & Grim, R. (2007). Leren veranderen [Bespreking van het boek Leren veranderen Een handboek voor de veranderkundige]. Zorgmarkt, 2, 38-39. Internal report Glind, I.M. van de & Goossensen, M.A. (2007). Ziekenhuiszorg in eenbedskamers, achtergrondrapport. ERASMUS MC. Glind, I.M. van de & Goossensen, M.A. (2007). Ziekenhuiszorg in eenbedskamers, conclusies en advies. ERASMUS MC. Goossensen, M.A., Koopmanschap, M.A., Grit, K.J., Mul, M. de, Koolman, A.H.E. & Zijlstra, P (2007). Evaluatie Proeftuin Farmacie Groningen. health policy and management (iBMG). Mil, B.P.A., Putters, K., Bal, R.A., Frederiks, B.J.M., Vreeman, W.L. & Noordink, M. (2007). Onderzoek naar de uitbreiding van de Wet gelijke behandeling op grond van handicap of chronische ziekte voor het terrein van goederen en diensten. health policy and management (iBMG). Ngo, T.M.D. (2007). Enhancing Engagement in medical leadership: a rapid survey of international experience. health policy and management (iBMG). Scheer, W.K. van der, Meurs, P.L. & Ngo, T.M.D. (2007). Bestuurders in beweging. health policy and management (iBMG).

EMC NIHES-05-63-02 - Quality and efficiency in health care (theme 2) Programme design in brief The programme health technology assessment, which is organised and carried out within iMTA, has grown considerably in the period '97/2004. An important impetus at the start of the development in this period was a large grant from the Ministry of Health for iMTA to support medical associations in their development of practice guidelines. In these guidelines for medical practice not only effectiveness but also the cost-effectiveness of various preventive or curative strategies is considered when making recommendations on how to deal with a specific health problem. Furthermore, important methodological topics have been studied, such as the measurement and valuation of productivity costs, the analysis of models describing patients' preferences, the valuation of informal care in economic evaluation, statistical methods of economic evaluation, efficacy-effectiveness issues, and valuation of quality of life. The NWO-subprogram on methodology of 'health technology assessment' as part of the larger program on cost effectiveness of health care programs provided the opportunity to carry out new methodological projects. Furthermore, a large number of practical, often international, projects have been carried out for various diseases and health care programs. An innovative example is a large multinational trial on the management of BPH-treatment in 6 European countries. This is the first large-scale naturalistic prospective economic evaluation in Europe. Finally, a number of projects in low-income countries have been carried out, some of which in close cooperation with WHO Geneva. Almost 100% of the research in this programme is externally funded Key figures Department

SP1

SP2

SP3

SP4

SPtot

health policy and management

5,72

5,12

0

14,8

25,64

public health

1,09

0

0

0,4

1,49

Total

6,81

5,12

0

15,2

27,13

T1

T2

1

T3

0

Ttot

0

IS

1

FS

41

OP

11

Ptot

41

Theses Bekker, M.P.M. (2007, september 12). The politics of Healthy policies Redesigning health impact assessment to integrate health in public policy. EUR (239 pag.) (Delft: Eburon). Prom./coprom.: Prof.Dr. T.E.D. van der Grinten, dr. K. Putters & Prof.Dr. J.P. Mackenbach. Article/Letter to the editor Abdellaoui, M. & Bleichrodt, H. (2007). Eliciting Gul's theory of disappointment aversion by the tradeoff method. Journal of Economic Psychology, 28, 631-645. Abdellaoui, M., Bleichrodt, H. & Paraschiv, C. (2007). Loss Aversion Under Prospect Theory: A Parameter-Free Measurement. Management Science, 53(10), 1659-1674. Adams, S.A. & Bont, A.A. de (2007). Information Rx: Prescribing Good Consumerism and Responsible Citizenship. Health Care Analysis, 15(4), 273-290. Adams, S.A. & Bont, A.A. de (2007). More than just a mouse click: Research into work practices behind the assignment of medical trust marks on the World Wide Web. International Journal of Medical Informatics, 76S, S14-S20. Adams, S.A. (2007). Using bloggings tools to help individuals record their experiences: an exploration web applications in the Netherlands. Information Technology in Health Care, 130, 193-203. Baal, PHM, Brouwer, W.B.F., Hoogeveen, R.T. & Feenstra, T.L. (2007). Increasing tobacco taxes: A cheap tool to increase public health. Health Policy, 82, 142-152. Baal, PHM, Feenstra, T.L., Hoogenveen, R.T., Wit, GA de & Brouwer, W.B.F. (2007). Unrealated medical care in life years gained and the cost utility of primary prevention: in search of a 'perfect' cost-utility ratio. Health Economics, 16, 421433. Bal, R.A. & Mastboom, F. (2007). Engaging with Technologies in Practice: Travelling the Northwest Passage. Science as Culture, 16(3), 253-266. Bal, R.A., Mastboom, F., Spiers, H.P. & Rutten, H. (2007). The product and process of referral optimizing general practitioner-medical specialist interaction through information technology. International Journal of Medical Informatics, 76, 28-34. Baltussen, R.M.P.M., Asbroek, A.H.A. ten, Koolman, A.H.E., Shrestha, N., Bhattarai, P. & Niessen, L.W. (2007). A Rational multi criteria approach to Priority setting using multiple criteria: should a lung health programme be implemented in Nepal? Health Policy and Planning, 22, 178-185. Bekker, M.P.M. (2007). Welles /Nietes Wetenschap kan de politiek van gezond beleid niet vervangen. G vakblad over gezondheid en maatschappij, 23, 5.

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Bleichrodt, H. (2007). Reference-dependent utility with shifting refence points and incomplete preferences. Journal of Mathematical Psychology, 51, 266-276. Bleichrodt, H., Abellan-Perpi an, J.M., Pinto, J.L. & Mendez-Martinez, I. (2007). Resolving Inconsistencies in Utility Measurement Under Risk: Tests of Generalizations of Expected Utility. Management Science, 53(3), 469-482. Bont, A.A. de, Stoevelaar, H & Bal, R.A. (2007). Databases as policy instruments. About extending networks as evidencebased policy. Bmc Health Services Research, 7(200), 1-6. Bont, A.A. de, Zandwijken, G., Stolk, E.A. & Niessen, L.W. (2007). Prioritisation by physicians in the Netherlands The growth hormone example in drug reimbursement decisions. Health Policy, 80, 369-377. Bos, T. van den, Visser-Meily, A & Exel, N.J.A. van (2007). Optimalisering van zorg aan CVA pati쬫nten in de huisartsenpraktijk. Huisarts en Wetenschap, 50, 552-556. Bree, R. de, Putten, L. van der, Hoekstra, O.S., Kuik, D.J., Groot, C.A. de, Tinteren, H. van, Leemans, C.R. & Boers, M. (2007). A randomized trial of PET scanning to improve diagnostic yield of direct laryngoscopy in patients with suspicion of recurent laryngeal carcinoma after radiotherapy. Contemporary Clinical Trials, 28, 705-712. Bree, R. de, Reith, R., Quak, J.J., Groot, C.A. de, Agthoven, M. van & Leemans, C.R. (2007). Free radial forearm flap versus pectoralis major myocutaneous flap reconstruction of oral and oropharyngeal defects: a cost analysis. Clinical Otolaryngology, 32, 275-282. Brouwer, W.B.F., Exel, N.J.A. van, Baal, P. & Polder, J. (2007). Economics and public health: Engaged to be happily married! European Journal of Public Health, 17(2), 122-123. Brouwer, W.B.F. & Stolk, E.A. (2007). De grenzen van het pakket. IKR-bulletin (Rotterdam), 31, 22-23. Brouwer, W.B.F. (2007). De markt is geen zorg! TSG, 4(84), 193-194. Brouwer, W.B.F. & Polder, J.J. (2007). Gereguleerde concurrentie: broodnodig. Tien woorden gezondheidseconomie. TSG, 85(8), 417-422. Brouwer, W.B.F. & Polder, J. (2007). Nuttige verzekering: Het verhaal van Kees, Truus, Bert & Bertine en Al. TSG, 85(6), 303-305. Buijsen, M.A.J.M. (2007). De euthanasieweg geevalueerd. Journaal Privacy Gezondheidszorg, 8, 107-109. Buijsen, M.A.J.M. (2007). De Euthanasieweg geevalueerd: enkele kritische kanttekeningen. Ars Aequi, 56(9), 669-672. Buijsen, M.A.J.M. (2007). De evaluatie van de Euthanasieweg: een verkapt pleidooi voor normalisering van de euthanasiepraktijk. TGE. Tijdschrift voor Gezondheidszorg & Ethiek, 17(4), 94-98. Buijsen, M.A.J.M. (2007). De normatieve grondslagen van het Nederlandse euthanasierecht. Pro Vita Humana, 3, 60-64. Buijsen, M.A.J.M. (2007). Esther Pans, De normatieve grondslagen van het Nederlandse euthanasierecht. Rechtsgeleerd Magazijn Themis, 168(2), 72-75. Buijsen, M.A.J.M. (2007). Verdere decriminalisering euthanasie ongewenst. Nederlands Juristenblad (NJB), 32, 20272028. Cohen, J.P., Faden, L., Predaris, S. & Young, B. (2007). Patient access to pharmaceuticals: an international comparison. European Journal of Health Economics (HEPAC), 8, 253-2696. Cohen, J.P., Stolk, E.A. & Niezen, M.G.H. (2007). The Increasingly Complex Fourth Hurdle for Pharmaceuticals. Pharmacoeconomics, 25(9), 727-734. Cohen, J.P. (2007). The new Dutch health insurance system and its implications for pharmaceutical innovation. International Journal of Pharmaceutical and Healthcare Marketing, 1(3), 214-225. Cuijpers, P., Smit, F., Oostenbrink, J.B., Graaf, R. de, Have, M. ten & Beekman, A. (2007). Economic costs of minor depression: a population-based study. Acta Psychiatrica Scandinavica, 115, 229-236. Donnell, O. O', Doorslaer, E.K.A. van, Rannan-Eliya, R.P., Somanathan, A., Adhikari, S.R., Harbianto, D., Garg, C.C., Hanvoravongchai, P., Huq, N., Karan, A., Leung, G.M., Wan Ng, C., Raj Pande, B., Tin, K., Tisayaticom, K., Trisnantoro, L., Zhang, Y. & Zhao, Y. (2007). The Incidence of Public Spending on Healthcare: Comparative Evidence from Asia. The World Bank Economic Review, 21, 93-123. Doorslaer, E.K.A. van, Donnell, O. O', Rannan-Eliya, R.P., Somanathan, A., Adhikari, S.R., Akkazieva, B., Harbianto, D., Garg, C.C., Hanvoravongchai, P., Herrin, A.N., Huq, N., Ibragimova, S., Karan, A., Lee, T.J., Leung, G.M., Lu, J.F.R., Ng,

K.Y.A., Pande, B.R., Racelis, R., Tao, S., Tin, K., Trisnantoro, L., Vasavid, C., Yang, B.M. & Zhao, Y. (2007). Castastrophic payments for health care in Asia. Health Economics, 16(11), 1159-1184. Dwarswaard, J., Hilhorst, M.T. & Trappenburg, M.J. (2007). Is er een dokter in de zaal? Filosofie en Praktijk, 28(5), 6-19. Dwarswaard, J. & Hilhorst, M. (2007). Zorgvernieuwing, vrouwen en reclame. VAMP, 35, 2-4. Egmond, C. van, Bekker, M.P.M., Bal, R.A. & Grinten, T.E.D. van der (2007). De Volksgezondheid Toekomst Verkenning als infrastructuur voor evidence-based gezondheidsbeleid. TSG, 85(7), 399-406. Exel, N.J.A. van, Graaf, G de & Brouwer, W.B.F. (2007). Care for a break? An investigation of informal caregivers' attitudes toward respite care using Q-methodology. Health Policy, 83, 332-342. Exel, N.J.A. van, Bobinac, A., Koopmanschap, M.A. & Brouwer, W.B.F. (2007). Providing informal care: a burden and a blessing. Health and Ageing, 16, 10-13. Galani, C.M., Schneider, H. & Rutten, F.F.H. (2007). Modelling the lifetime costs and health effects of lifestyle intervention in the prevention and treatment of obesity in Switzerland. International Journal Public Health, 52, 1-11. Goor, K.M., Peeters, A.J.G.E., Mahieu, H.F., Langendijk, J.A., Leemans, C.R., Verdonck, I.M. & Agthoven, M. van (2007). Cordectomy by Co2 laser or radiotherapy for small T1a glottic carcinomas: costs, local control, survival, wuality of life, and voice quality. Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 128-136. Gravelle, H., Brouwer, W.B.F., Niessen, L.W., Postma, M. & Rutten, F.F.H. (2007). Discouting in economic evaluations: stepping forward towards optima decision rules. Health Economics, 16, 307-317. Hakkaart- van Roijen, L., Zwirs, B.W.C., Bouwmans, C.A.M., Tan, S.S., Schulpen, T.W.J., Vlasveld, L. & Buitelaar, J.K. (2007). Societal costs and quality of life of children suffering from attention deficient hyperactivity disorder (ADHD). European Child & Adolescent Psychiatry, 16(5), 316-326. Hart, H.E., Redekop, W.K., Bilo, H.J.G., Meyboom- de Jong, B. & Berg, M. (2007). Health related quality of life in patients with type I diabetes mellitus: generic & disease-specific measurement. Indian Journal of Medical Research, 125, 203-216. Horn, E.K., Benthem, T.B. van, Hakkaart- van Roijen, L., Marwijk, H.W.J. van, Beekman, ATF, Rutten, F.F.H. & FeltzCornelis, C.M. van der (2007). Cost-effectiveness of collaborative care for chronically ill patients with comorbid depressive disorder in the general hospital setting a randomised controlled trial. Bmc Health Services Research, 7(28), 1-14. Hurdle, J.F., Adams, S.A., Brokel, J., Chang, B., Embi, P.J., Petersen, C., Terrazas, E. & Winkelstein, P. (2007). A Code of Professional Ethical Conduct for the American Medical Informatics Association: an AMIA Board of Directors Approved White Paper. JAMIA Journal of the American Medical Informatics Association, 14(4), 391-393. Ijff, M.A., Huijbregts, K.M.L., Marwijk, H.W.J. van, Beekman, ATF, Hakkaart- van Roijen, L., Rutten, F.F.H., Unutzer, J & Feltz-Cornelis, C.M. van der (2007). Cost-effectiveness of collaborative care including PST and an antidepressant treatment algorithm for the treatment of major depressive disorder in primary care; a randomiese clinical trial. Bmc Health Services Research, 7(34), 1-11. Jansen, E., Baltussen, R.M.P.M., Doorslaer, E.K.A. van, Ngirwamungu, E., Ngygen, M.P. & Kilima, P. (2007). An eye for inequality :how trachoma relates to poverty in Tanzania and Vietnam. Ophthalmic Epidemiology, 200(14), 278-287. Jansen, Y.J.F.M., Bont, A.A. de, Foets, M.M.E., Bruijnzeels, M.A. & Bal, R.A. (2007). Tailoring intervention procedures to routine primary health care practice: an ethnographic process evaluation. Bmc Health Services Research, 7(125), 1-8. Jones, A.M., Koolman, A.H.E. & Doorslaer, E.K.A. van (2007). The impact of having supplementary private health insurance on the use of specialists. Annales d'Economie et de Statistique, 83/84, 1-25. Koopmans, G.T. & Lamers, L (2007). Gender and health care utilization: The role of mental distress and help-seeking propensity. Social Science & Medicine, 64, 1216-1230. Koopmanschap, M.A. & Steenhoek, A. (2007). Kosten voor dure medicijnen rijzen de pan uit Groter gebruik: lagere prijs. PW, 142, 1-1. Krol, H.M., Koopman, M.I., Uyl - de Groot, C.A. & Groot, C.A. de (2007). A systematic review of economic analyses of pharmaceutical therapies for advanced colorectal cancer. Expert Opinion on Pharmacotherapy, 8, 1313-1328. Lai, T., Habicht, J., Reinap, M., Chrisholm, D. & Baltussen, R.M.P.M. (2007). Costs, health effects and cost-effectiveness of alcohol and tobacco control strategies in Estonia. Health Policy, 84, 75-88. Lamers, L.M., Groot, C.A. de & Buijt, I. (2007). The Use of Disease-Specific Outcome Measures in Cost-Utility Analysis. Pharmacoeconomics, 25(7), 591-603.

Lintsen, AME, Eijkemans, M.J.C., Hunault, C.C., Bouwmans, C.A.M., Hakkaart- van Roijen, L., Habbema, J.D.F. & Braat, D.D.M. (2007). Predicting ongoing pregnancy chances after IVF and ICSI: a national prospective study. Human Reproduction, 22(9), 2455-2462. Lu, J.F.R., Leung, G.M., Kwon, S., Tin, K.Y.K., Doorslaer, E.K.A. van & Donnell, O. O' (2007). Horizontal equity in health care utilization evidence from three high-income Asian economies. Social Science & Medicine, 64, 199-212. Niessen, L.W., Grijseels, E.W.M., Koopmanschap, M.A. & Rutten, F.F.H. (2007). Economic analysis for clinical practice the case of 31 national consensus guidelines in the Netherlands. Journal of Evaluation in Clinical Practice, 13(1), 68-78. Niezen, M.G.H., Bont, A.A. de, Stolk, E.A., Eyck, A., Niessen, L.W. & Stoevelaar, H (2007). Conditional reimbursement within the Durch drug policy. Health Policy, 84, 39-50. Polder, JJ & Brouwer, W.B.F. (2007). Een mistroostige wetenschap? TSG, 85(4), 202-204. Poleij, M.J., Edelenbos, K.I., Mosseveld, B.M.T., Wijk, M.A.M. van, Bakker, D.H. de, Lei, J. van der & Molken, M.P.M.H. van (2007). Cost consequences of implementing an electronic decision support system for ordering laboratory tests in primary care: Evidence from a controlled prospective study in the Netherlands. Clinical Chemistry, 53(2), 213-219. Rutten, F.F.H. & Brouwer, W.B.F. (2007). "Value for money" in de zorg; geen woorden maar daden. M en O, 61, 171-179. Rutten - van Mölken, M.P.M.H., Nooten, F.E. van, Lindemann, M., Caeser, M. & Calverley, P.M.A. (2007). A 1-Year Prospective Cost-Effectiveness Analysis of Roflumilast for the Treatment of Patient. Pharmacoeconomics, 25(8), 695-711. Rutten - van Mölken, M.P.M.H., Oostenbrink, J.B., Miravitlles, M. & Monz, BU (2007). Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain. European Journal of Health Economics (HEPAC), 8, 123-135. Sendi, P., Brouwer, W.B.F., Bucher, HC, Weber, R. & Battegay, M. (2007). When time is more than money; The allocation of time between work and leisure in HIV-infected patients. Social Science & Medicine, 64, 2355-2361. Steenhoek, A. (2007). Dure geneesmiddelen: waait ook nu de bui weer over? IKR-bulletin (Rotterdam), 31, 4-5. Steenhoek, A. (2007). Patiënt krijgt zwartepiet. Pharmaceutisch Weekblad, 142, 1-1. Stoop, A.P., Bal, R.A. & Berg, M. (2007). OZIS and the politics of safety: Using ICT to create a regionally accessible patient medication record. International Journal of Medical Informatics, 76S, S229-S235. Trappenburg, M.J. & Dwarswaard, J. (2007). Rolconflicten. Huisarts en Wetenschap, 50(10), 512-513. Uyl - de Groot, C.A. & Steenhoek, A. (2007). Nieuwe 'dure' kankergeneesmiddelen en kosteneffectiviteitsanalyses: hoe is de stand van zaken? IKR-bulletin (Rotterdam), 31, 28-30. Book - monograph - book editorial Buijsen, M.A.J.M. (2007). Wet- en regelgeving in de zorg Bijzondere patientenrechten in de gezondheidszorg. Eindhoven: SBO. Part of book - abstract Adams, S.A. & Boot, C.R.L (2007). Gewoon digitaal. In J. Steyaert & J..de Haan (Eds.), Jaarboek ICT en samenleving 2007 (pp. 189-10). Amsterdam: Boom. Bekker, M.P.M., Wallenburg, I. & Helderman, J.K. (2007). Verschuivende verhoudingen: de marges van overheidsbeleid bij overgewicht. In Dagevos H. & Munnichs G (Eds.), De Obesogene samenleving Maatschappelijke perspectieven op overgewicht (pp. 155). Amsterdam: Amsterdam University Press. Brouwer, W.B.F. & Rutten, F.F.H. (2007). Zorgverzekeringen: een centraal gezondheidsonderzoeksgebied. In Handboek gezondheidszorgonderzoek (pp. 208-17). Bohn Stafleu van Loghum. Buijsen, M.A.J.M. (2007). Actieve levensbeeindiging bij ernstig lijdende pasgeborenen in Nederland. In W.J Mgr.dr. Eijk, R. Br.Dr. fc Stockman & J.A. dr. Raymakers (Eds.), Kwaliteit van Leven in Christelijk Perspectief (pp. 93-6). Gent: Canon Triest. Buijsen, M.A.J.M. (2007). Notities van zelfbeschikking. In R Janse, S Teakema & T Hol (Eds.), Rechtsfilosofische annotaties (pp. 114-7). Nijmegen: Ars Aequi Libri. Dwarswaard, J., Hilhorst, M. & Trappenburg, M.J. (2007). Toch maar liever timmerman? In Jose Kole & Doret de Ruyter (Eds.), Werkzame Idealen Etnische reflecties op professionaliteit (pp. 37-4).

Foets, M.M.E., Schuster, J. & Stronks, K. (2007). Gezondheids(zorg) onderzoek onder allochtone bevolkingsgroepen. In M Foets, J. Schuster & K. Stronks (Eds.), Gezondheids(zorg) onderzoek onder allochtone bevolkingsgroepen. Amsterdam: Askant. Foets, M.M.E. (2007). Crossculturele validiteit Spanning tussen theorie en praktijk. In MME Foets, J. Schuster & K. Stronks (Eds.), Gezondheids(zorg)onderzoek onder allochtone bevolkingsgroepen een praktische introductie (pp. 77). Amsterdam: Askant. Foets, M.M.E., Suurmond, J. & Stronks, K. (2007). De relatie tussen etnische herkomst en gezondheidszorg Een conceptualisering. In MME Foets, J. Schuster & K. Stronks (Eds.), Gezondheids(zorg)onderzoek onder allochtone bevolkingsgroepen een praktische introductie (pp. 29). Amsterdam: Askant. Foets, M.M.E. (2007). Steekproeftrekking indentificatie van de allochtone populatie. In MME Foets, J. Schuster & K. Stronks (Eds.), Gezondheids(zorg)onderzoek onder allochtone bevolkingsgroepen een praktische introductie (pp. 53). Amsterdam: Askant. Polder, J., Baal, P., Exel, N.J.A. van & Brouwer, W.B.F. (2007). Preventie: niet altijd goedkoop, wel vaak een goede koop. Een economisch verhaal over preventie en de waarde van gezondheid. In Jaarboek Publieke Gezondheid (pp. 128-3). Abcoude: Stichting Public Health Forum. Polder, J.J., Baal, PHM, Exel, N.J.A. van & Brouwer, W.B.F. (2007). Een economisch verhaal over preventie en de waarde van gezondheid. In Jaarboek Publieke Gezondheid 2007 (pp. 128-3). Abcoude: Stichting Public Health Forum. Rutten, F.F.H. & Brouwer, W.B.F. (2007). Economische evaluaties in de gezondheidszorg. In T. Dr Ploch, R.E. Dr Juttmann, N.S. Prof.dr. Klazinga & J.P. Prof.dr Mackenbach (Eds.), Handboek gezondheidszorgonderzoek (pp. 132-10). Bohn Stafleu van Loghhum. Rutten, F.F.H. (2006). Nieuwe tijden vragen om nieuw onderzoek. In Farma Merk Waardig (pp. 129-133). Amsterdam: Farma Innovatie Discussie Platform. Internal report Groenewoud, S.., Kreuger, L. & Exel, N.J.A. van (2007). Keuzeprocessen van zorgconsumenten met Knieartrose, de ziekte van Alzheimer of Chronische Depressie: Drie Q-methodologische studies. health policy and management (iBMG). External report Bekker, M.P.M. & Veerman, J.L. (2007). Gezondheidseffectschatting voor gezond beleid: teamsport op projectbasis Gezondheidskundige en bestuurskundige inzichten en methoden voor GES. Rotterdam: iBMG Erasmus MC. Berg, M.J. van den, Koopmanschap, M.A., Bakker, D.H. de & Verheij, R.A. (2007). Samenwerking en substitutie in Gezondheidscentrum West Evaluatie van de eerste ervaringen met ge ntegreerde eerstelijnszorg volgens het Menzismodel. Utrecht: Nivel. Dijstelbloem, H., Meurs, P.L. & Schrijvers, E.K. (2007). Maatschappelijke dienstverlening. Een onderzoek naar vijf sectoren. Amsterdam: Amsterdam University Press.

EMC NIHES-05-63-03 - Competition and regulation in health care (theme 1) Programme design in brief The programme "structure and finance of health care" has a strong economic perspective as well as a judicial perspective. Research focuses on some fundamental aspect of the market-oriented health care reforms that are taking place in the Netherlands as well as in many other countries. The risk-adjuster "Pharmacy Cost Group", developed by the health economics group, is considered to be in the forefront of the international risk adjustment research. The Dutch government has implemented this new risk-adjuster in the Dutch health insurance system in 2002. Research activities are currently dealing with the following topics: structure of health care systems, legal aspects of health care reform, uncertainty and equilibrium on the market for health insurers, regulated competition in health care, competition policy, risk adjusted premium subsidies for health insurance, determinants of consumer choice of health plan, consumer information, bonuses for GPs, equity in the finance and delivery of health care and the consequences of the European Union for structure and finance for the Dutch Health care system. The research programme on "equity in health and health care" focuses on the national and international assessment of health equity and inequality. The scope of the research activities has broadened over the period under consideration from the developed world (OECD countries) to the less developed world. In collaboration with the World Bank the methods for measuring inequality and inequity have been adapted to low-income countries and equity objectives, and have been applied to data from a number of developing nations. The measurement methods of the ECuity Project, which is co-ordinated by the group, have now become adopted as a worldwide standard for assessing the equity performance of health systems and the consequences of reforms, as witnessed by their adoption or explicit reference in all major efforts at system (equity) performance evaluation such as the Rockefeller Foundation's Global Health Equity Initiative, the WHO's World Health Report, the World Bank's World Development Report and the OECD's Framework for Health System Performance Key figures Department

SP1

SP2

SP3

SP4

SPtot

health policy and management

2,62

1,48

0

5,41

9,51

Total

2,62

1,48

0

5,41

9,51

T1

T2

2

T3

0

Ttot

0

IS

2

FS

8

OP

7

Ptot

72

Theses Paolucci, F. (2007, december 06). The design of basic and supplementary health care financing schemes: implications for efficiency and affordability. EUR. Prom./coprom.: Prof.Dr. W.P.M.M. van de Ven & Prof.Dr. F.T. Schut. Stam, P.J.A. (2007, oktober 17). Testing the effectiveness of risk equalization models in health insurance. EUR (317 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof.Dr. W.P.M.M. van de Ven & Dr. R.C.J.A. van Vliet. Article/Letter to the editor Agyemang, C, Bhopal, R. & Redekop, W.K. (2007). Does the pulse pressure in people of European, African and South Asian descent differ? A systematic review and meta-analysis of UK data. Journal of Human Hypertension, 21, 598-609. Akveld, J.E.M. & Hermans, H.E.G.M. (2007). Commentaar op rapport over toekomst Rijksvaccinatieprogramma. Zorg & Financiering, 4, 16-19. Akveld, J.E.M. & Hermans, H.E.G.M. (2007). Duits onderzoek bevestigt: systeemverandering orgaandonatie is nu noodzakelijk. Zorg & Financiering, 10, 23-25. Akveld, J.E.M. & Hermans, H.E.G.M. (2007). Nivel-rapport toont falen van huidige wet op de orgaandonatie aan. Zorg & Financiering, 8, 23-26. Berg, B van den, Stam, P.J.A. & Laske-Aldershof, T. (2007). Preferenties voor kwaliteit van zorg gemeten met de vignettenmethode. TSG, 85(6), 345-353. Berg, B. van den, Stam, P.J.A. & Laske-Aldershof, T. (2007). Het meten van kwaliteitsvoorkeuren in de zorg. Tijdschrift voor Politieke Ekonomie, 28(1), 82-92. Boonen, L.H.H.M. & Schut, F.T. (2007). Effect van prikkels op keuze voor zorgaanbieders. Economisch-Statistische Berichten, 2, 651-653. Bosschaart, A.N., Hulst, E.H. & Haan, F. de (2007). De plicht van iedere hulpverlener. Medisch Contact, 62(48), 19841987. Brouwer, W.B.F., Exel, N.J.A. van & Baal, P. (2007). De kosten in gewonnen levensjaren - tijd voor een nieuwe richtlijn! VGE Bulletin, 24(1), 11-14. Buijsen, M.A.J.M. (2007). Centrale vraagstukken in de bioethiek. TGE. Tijdschrift voor Gezondheidszorg & Ethiek, 17(4), 127-128.

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Buijsen, M.A.J.M. (2007). Werken aan de werkelijkheid Imagocampagne: nee Imagocampagnes voor de zorg zijn weggegooid geld. Het gaat om tevredenheid van verpleegkundigen. Nursing, 13, 18-18. Cohen, J.P., Paquette, C. & Cairns, C. (2007). Can Medicare draw lessos from Dutch experience with a national formulary. Drug Information Journal, 41, 257-272. Danis, M., Binnendijk, E., Ost, A., Vellakkal, S., Koren, R. & Dror, D.M. (2007). Eliciting the Health Insurance Benefit Choices of Low-income Populations in India with the CHAT Exercise. Social Science & Medicine, 64(4), 884-896. Dror, D.M., Koren, R., Ost, A., Binnendijk, E., Vellakal, S. & Danis, M. (2007). Health Insurance benefit packages prioritized by low-incoe clients in India: Three criteria to estimate effectiveness of choice. Social Science & Medicine, 64, 884-896. Dror, D.M. (2007). Micro Health Insurance in India: Pointers for Progress. IRDA Journal, 5(12), 7-11. Dror, D.M. (2007). Why '' one-size-fits-all'' health insurance products are unsuitable for low-income persons in informal economy in India. Asian Economic Review, 49(1), 47-56. Dror, D.M., Rademacher, R. & Koren, R. (2007). Willingness to pay for health insurance among rural and poor persons: Field evidence from seven micro health insurance units in India. Health Policy, 82(1), 12-27. Enthoven, A.C. PhD & Ven, W.P.M.M. van de (2007). Going Dutch-Managed-Cometition Health Insurance in the Netherlands. New England Journal of Medicine, 357(24), 2421-2426. Geest, S.A. van der, Mosca, I., Pellikaan, F. & Varkevisser, M. (2007). In beweging voor de fysiotherapeut. EconomischStatistische Berichten, 4516, 506-508. Grinten, T.E.D. van der (2007). Ondernemen voor de zorg. M en O, 61(2), 209-214. Grinten, T.E.D. van der (2007). Stelselherziening van de Nederlandse gezondheidszorg. TSG, 85(4), 227-233. Hermans, H.E.G.M. (2007). Aanbestedingsplicht ziekenhuizen door recente rechtspraak definitief van de baan? Zorg & Financiering, 9, 9-17. Hermans, H.E.G.M. (2007). Belangrijk nieuws arrest Europese Hof over vergoeding ziekenhuiskosten buitenland. Zorg & Financiering, 5, 106-108. Hermans, H.E.G.M. (2007). Conclusie Advocaat-Generaal bij de Hoge Raad over Europees aanbesteden door Amphia gunstig voor ziekenhuizen. Zorg & Financiering, 4, 28-29. Hermans, H.E.G.M. (2007). NZA publiceert beleidsregel aanmerkelijke marktmacht in de zorg. Zorg & Financiering, 8, 2931. Hermans, H.E.G.M. (2007). Uitspraak college van beroep voor het bedrijfsleven over vergoeding kosten MRSA in de zaak valkenhof tegen nza. Zorg & Financiering, 1, 51-53. Hermans, H.E.G.M. (2007). Wat mij opvalt? Facelift of 'Extreme Makeover' voor oude dame? Zorg & Financiering, 5, 1-1. Hermans, H.E.G.M. (2007). Wat mij opvalt... Verdere afslankinhg aantal toezichthouders is mogelijk. Zorg & Financiering, 8, 967. Hermans, H.E.G.M. (2007). Wat mij opvalt... Zorg voor onverzekerden: begripsverwarring en onnodige beperkingen. Zorg & Financiering, 2, 168-168. Hermans, H.E.G.M. (2007). Zijn zorginstellingen sinds het Amphia-arrest nog aanbestedingsplichtig? Nederlands Juristenblad (NJB), 31, 1637-1637. Hulst, E.H. (2007). Is een arts te allen tijde verpicht tot reanimatie over te gaan, ook als de arts en college unaniem van mening zijn dat dit een zinloze medische handeling is? Internisten Vademecum, 13(6). Hulst, E.H. (2007). Is een arts te allen tijde verplicht tot reanimatie over te gaan, ook als de arts en colleagae unaniem van mening zijn dat dit een zinloze medische handeling is? Reumatologen Vademecum, 10(20). Hulst, E.H. (2007). Wanneer eindigt de verantwoordelijkheid van de huisarts en wanneer begint die van het ambulancepersoneel? Vademecum, 1-1. Kleef, R.C. van, Beck, K., Ven, W.P.M.M. van de & Vliet, R.C.J.A. van (2007). Does risk equalization reduce the viability of voluntary deductibles? International Journal of Health Care Finance and Economics, 7, 43-58.

Kleef, R.C. van, Ven, W.P.M.M. van de & Vliet, R. van (2007). Een effectiever eigen risiso in de zorg. EconomischStatistische Berichten, 92(4515), 459-461. Luijkx, K.G. & Putters, K. (2007). Prosumerisme in de zorg. TSG, 8(6), 307-311. Meindertsma, M. & Putters, K. (2007). De herontdekking van nationale kaderstelling. Proeflokaal, 22, 13-21. Nijdam, W.M., Levendag, P.C., Fuller, D., Schulz, R., Prevost, J.G.H.G., Smit, I. & Uyl - de Groot, C.A. (2007). Robotic radiosurgery vs. brachytherapy as a boost to intensity modulated radiotherapy for tonsillar fossa and soft palate tumors: the clinical and economic impact of an emerging technology. Technology Cancer Research Treatment, 6, 611-619. Paolucci, F., Schut, F.T., Beck, K., Gress, S., Voorde, C. van de & Zmora, I. (2007). Supplementary health insurance as a tool for risk-selection in mandatory basic health insurance markets. Health Economics, Policy and Law, 2, 173-192. Pirnejad, H., Bal, R.A., Stoop, A.P. & Berg, M. (2007). Inter-onganisational communication networks in healthcare: centralised versus decentralised approaches. International Journal of Integrated Care, 7, 1-12. Prinsze, F.J. & Vliet, R.C.J.A. van (2007). Health-Based Risk Adjustment: Improving the Pharmacy-Based Cost Group Model by Adding Diagnostic Cost Groups. Inquiry. A Journal of Medical Care Organization, Provision and Financing, 44, 469-480. Putters, K. & Twist, M.J.W. van (2007). Bijdragen aan beleid of tegenspel bieden? Modaliteiten voor een vernieuwd adviesstelsel. Bestuurswetenschappen, 61(2), 11-19. Putters, K. (2007). Een PvdA keurmerk voor de WMO. Proeflokaal, 7(24), 19-26. Putters, K. (2007). Twee handen op een buik? Levert het spanningsveld tussen concurreren en samenwerken innovatiekracht op? HMF, 2, 7-11. Schut, F.T. (2007). Collectieve zorgverzekeringen: opkomst, kenmerken en betekenis. Zorg & Financiering, 6, 10-21. Schut, F.T. (2007). Pas op de plaats nodig voor nieuwe stap voorwaarts. Christen Democratische Verkenningen, 28(3), 128-137. Schut, F.T. (2007). Wordt de zorg een markt? M en O, 61(2), 191-202. Varkevisser, M. & Geest, S.A. van der (2007). Why do patients bypass the nearest hospital? An empirical analysis for orthopaedic care and neurosurgery in the Netherlands. European Journal of Health Economics (HEPAC), 8, 287-295. Varkevisser, M., Geest, S.A. van der, Maasland, E. & Schut, F.T. (2007). Opleiden medisch specialisten moet transparanter. Economisch-Statistische Berichten, 4511, 340-342. Ven, W.P.M.M. van de, Beck, K., Voorde, C. van de, Wasem, J. & Zmora, I. (2007). risk adjustment and risk selection in Europe: 6 years later. Health Policy, 83, 162-179. Book - monograph - book editorial Buijsen, M.A.J.M. (2007). Wet- en regelgeving in de zorg. Eindhoven: SBO. Buijsen, M.A.J.M. (2007). Wet- en regelgeving in de zorg Inleiding gezondheidsrecht. Eindhoven: SBO. Buijsen, M.A.J.M. (2007). Wet- en regelgeving in de zorg Rechtshandhaving in de gezondheidszorg. Eindhoven: SBO. Donnell, O. O', Doorslaer, E.K.A. van, Wagstaff, A. & Lindelow, M. (2007). Analyzing Health Equity Using Household Survey Data: A Guide to Techniques and Their Implementation. Washington DC: World Bank 2007. Hulst, E.H. (2007). Wet- en regelgeving in de zorg 6 Pati쬫ntenrechten in de gezondheidszorg. Eindhoven: SBO. Hulst, E.H. (2007). Wet- en regelgeving in de zorg 7 Pati쬫ntenrechten in de gezondheidszorg. Eindhoven: SBO. Noord, T.J.C. van & Hulst, E.H. (2007). Wet- en regelgeving in de zorg Preventiewetgeving en wetgeving openbare gezondheidszorg. Eindhoven: SBO. Noord, T.J.C. van & Hulst, E.H. (2007). Wet- en regelgeving in de zorg 13 Preventieweggeving en wetgeving openbare gezondheidszorg. Eindhoven: SBO. Part of book - abstract Buijsen, M.A.J.M. (2007). De autonomie van de dokter. In F.H.J.G. mr.drs Brekelmans, M.A.J.M. mr.dr. Buijsen, M. mevr.mr Es, P.W.A. mr.dr. Huisman & B.P. prof.mr.drs Vermeulen (Eds.), De docent: onderdaan of autoriteit? (pp. 85). Den Haag: Sdu uitgevers.

Buijsen, M.A.J.M. (2007). De betekenis van solidariteit in de gezondheidszorg. In MAJM mr.dr Buijsen, W.van.de Donk & N.van Gestel (Eds.), Marktwerking versus solidariteit (3, 3) (pp. 65-5). Venlo: Thijmgenootschap. Buijsen, M.A.J.M. & Exter, A. den (2007). Gelijkheid en het recht op gezondheidszorg. In A.den Exter (Ed.), SociaalEconomisch recht Gelijkheid en recht op zorg (pp. 13-1). Nijmegen: Ats Aequi Libri. Grinten, T.E.D. van der & Drewes, J. (2007). Zorgverzekeraar & preventie nieuwe kansen of business as usual? In Jaarboek Publieke Gezondheid 2007 (pp. 154-3). Abcoude: Forum Stichting Public Health Forum. Helderman, J.K. & Grinten, T.E.D. van der (2007). Bevorderen, voorkomen genezen en ondersteunen. In Volksgezondheid en gezondheidszorg in de verzorgingsstaat (pp. 195-8). Den Haag: Lemma. Hermans, H.E.G.M. (2007). Het recht op noodzakelijke zorg. In Gelijkheid en recht op zorg (pp. -2). Hermans, H.E.G.M. (2007). Mededingingsrechtelijke aspecten en rol, werking en inrichting vande Zorgautoriteit. In J.J. dr.ir. Zuurbier & Y. Krabbe-Alkemade (Eds.), Onderhandelen over DBC's (pp. 143-8). Maarssen: Elsevier Gezondheidszorg. Hermans, H.E.G.M. & Donk, R.N. van (2007). Overeenkomstenstelsel zorg Gezondheidswetgeving in de praktijk. In Overeenkomstenstelsel zorg. Houten: Bohn Stafleu van Loghum. Hermans, H.E.G.M. (2007). Tekst en toelichting Zorgverzekeringswet. In Tekst en toelichting Zorgverzekeringswet. Den Haag: SDU Uitgevers. Hermans, H.E.G.M. (2007). Ziekenhuizen in een gelaagde en pluriforme rechtsorde. In A.C. Hendriks & ten HM Napel (Eds.), Volksgezondheid in een veellagige rechtsorde Eenheid en verscheidenheid van norm en praktijk (pp. 153-11). Alphen aan den Rijn: Kluwer. Hout, E. van & Putters, K. (2007). Leiderschap in maatschappelijke organisaties. In E.M.H. Cornelissen, P.H.A. Frissen, S. Kensen & T. Brandsen (Eds.), Betoverend Bestuur; Legitimitteit, vitaliteit, meervoudigheid (pp. 219-11). Den Haag: Lemma. Meurs, P.L. & Sie Dhian Ho, M. (2007). Inleiding. In Democraat met beleid (pp. 13-19). Den Haag: Wetenschappelijke Raad voor het Regeringsbeleid. Meurs, P.L. (2007). Verantwoording en toezicht in de maatschappelijke dienstverlening. In Democraat met beleid (pp. 8596). Den Haag: Wetenschappelijke raad voor het regeringsbeleid. Putters, K., Hout, E.J.Th. van & Cardoso Ribeiro, T. (2007). Consequenties van de Wet Maatschappelijke Ondersteuning. In De zorg van het lokaal bestuur. Assen: Van Gorcum. Putters, K., Helderman, J.K. & Grinten, T.E.D. van der (2007). Gezondheidszorgonderzoek: de bestuurswetenschappelijke invalshoek. In T. Plogch, R.E. Juttman, N.S. Klazinga & J.P. Mackenbach (Eds.), Handboek Gezondheidszorg (pp. -15). Houten: Bohn Stafleu van Loghum. Putters, K. (2007). Marktgedrag en innovatie: over de ruimte voor innovatie tussen samenwerking en concurrentie. In Marktgedrag en innovatie Over de ruimte voor innovatie tussen samenwerking en concurrentie. Leiden: STG Health Management Forum. Putters, K. (2007). Passende instrumenten voor onderwijsbeleid. In Beleidsinstrumenten in het onderwijs. Den Haag: Onderwijsraad. Putters, K., Meurs, P.L. & Schulz, M. (2007). Van government naar governance in de hybride sectoren zorg en onderwijs. In G. Minderman (Ed.), Governance in hybride sectoren. Den Haag: Sdu. Schut, F.T. (2007). Concurreren in de GGZ: economisch verantwoord? In JN dr. Keeman, PW Prof.dr. Leeuw, JA dr. Mazel & FG Prof.dr. Zitman (Eds.), Het medisch jaar 2007. Houten: Bohn Stafleu van Loghum. Vrielink, M., Hout, E.J.Th. van & Putters, K. (2007). Governance van lokale zorg- en dienstverlening. In E.M.H. Cornelissen, P.H.A Frissen, S. Kensen & T. Brandsen (Eds.), Betoverend Bestuur; Legitimiteit, vitaliteit, meervoudigheid (pp. 241-12). Den Haag: Lemma. Internal report Bruijn, D. de & Schut, F.T. (2007). Evaluatie aanvullende verzekeringen 2007. ERASMUS MC. Buiting, P.H., Meurs, P.L. & Ngo, T.M.D. (2007). Caring for Europe. health policy and management (iBMG).

Ngo, T.M.D., Wetering, E.J. van de, San Giorgi, M., Weiss, F. & Stolk, E.A. (2007). Background document for the PROGRESS workshop on 'Policy options for promoting rational resource use in the areas of health care and long-term care. health policy and management (iBMG). Schut, F.T. & Bruijn, D. de (2007). Collectieve zorgverzekeringen en risicoselectie Onderzoek uitgevoerd in opdracht van de Nederlandse Patiënten Consumenten Federatie. ERASMUS MC. Varkevisser, M., Geest, S.A. van der, Maasland, E. & Schut, F.T. (2007). Naar een meer transparante opleidingsmarkt Marktprikkels in het opleidingsfonds. ERASMUS MC. External report Grit, K.J. & Bont, A.A. de (2007). Zorgaanbieders en de ethische aspecten van marktwerking De Praktijopgave van het creëren van een passende zorgmarkt. Rotterdam: Eramus MC iBMG. Jerak, S. (2007). "Germany" in: Chris Ham, Enchancing Engagement in Medical Leadership: A Rapid Survey of International Experience. Birmingham: Health Services Management Centre, University of Birmingham and NHS Institute for Innovatione and Improvement. Putters, K. & Frissen, P.H.A. (2007). Vertrouwen voor en door innovatie Over de noodzaak van checks & balances bij vernieuwingsprocessen in de zorg. Tilburg: Universiteit Tilburg. Other output Koolman, A.H.E. (2007). Unmeet need for Health care in Europa. Proceedings of eth EU-SILC conference Helsinki: Helsinki (2007, augustus 06 - 2007, november 08).