Job Title:

Professor Head of Department of Haematology

School/ Directorate:

Department of Haematology Cardiff School of Medicine

Duration:

Open-Ended.

Salary Details:

A point on the Clinical Academic Salary Scale, for Clinical Professors holding honorary consultant contracts.

Hours of work:

This is a full-time position of 37.5 hours per week.

Relocation Expenses:

Relocation expenses will be available for staff needing to relocate in order to take up employment with the University. Full details can be found at www.cardiff.ac.uk/humrs/newstaff/index.html Information on properties and schools in the Cardiff area can be found at www.icwales.co.uk

Responsible to:

For academic duties, you will be responsible to the Dean of Medicine or his designates. For clinical duties, you will be responsible to the Clinical Director and professionally accountable to the Medical Director of Cardiff and Vale University Health Board.

Date of Appointment:

Main Function of Post:

This post is available immediately.

The School of Medicine at Cardiff University aims to pursue the highest standards of research, education and training in medicine and related subjects, and is internationally-regarded for the high quality of its research. With extremely strong and positive links with the Welsh Government, the School is in a prime position to influence and enhance the future health and well-being

of the people of Wales, and the wider world. Under the leadership of its Dean, Professor John Bligh, the School of Medicine is now seeking to appoint a Chair and Head of Department in Haematology in order to build future leadership capacity in, and strengthen, key areas of haematology research and education. This replacement Professorial appointment will benefit from a recent £16 million investment into the infrastructure of the School of Medicine and will provide the chance to drive world-leading research in a supportive and dynamic environment. Professor of Haematology The Clinical Department of Haematology is internationally recognised as a leader in basic and clinical research in haematological malignancies and its leadership of large multicentre, multinational clinical trials. The Department hosts the Cancer Research UK’s (CRUK) Cardiff Experimental Cancer Medicine Centre and, from October 2011, will sit within the newly formed Institute of Cancer and Genetics. The Professor of Haematology will be the lead academic for Haematology in the School and will be responsible for the continued success of the Department’s activities. The appointee will have the opportunity to be included within two new cancer initiatives at Cardiff University. CRUK centre status was awarded in 2010, bringing additional professorial and support posts along with an allocation of CRUK studentships, The Cardiff Cancer Stem Cell Institute was launched in 2011, bringing additional senior academic staff, plus a number of postdoctoral fellowships. Together, these initiatives highlight the University’s commitment to build on the internationally excellent research in cancer at Cardiff.

Job Description:

Research  You will be expected to establish and build an internationally competitive research programme and assist others in the Department and Institute to develop their research capacity. Teaching  You will work with members of the Institute of Medical Education to coordinate the delivery of haematology teaching in the undergraduate course. Clinical For NHS duties the post holder will be responsible to the Clinical Director (currently Dr J Kell) and professionally accountable to the Medical Director.

 To provide a consultant service in Haematology and   

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clinical leadership to the relevant team. To provide direct clinical care and support professional activities in line with the provisions of the amended Consultant Contract for Wales. To develop the clinical and translational research programmes to provide state of the art care to patients with haematological cancers. To lead development of Haematology services, ensuring national and regional directives and guidance are incorporated into local practice and planning. To inform about specific and wider issues in Haematology through educational programmes (undergraduate and postgraduate) both locally and nationally. To provide professional supervision and management of junior staff. If appropriate, the post holder will be named in the contracts of junior staff as the person responsible for overseeing their training. To develop specialist interests complementary to the present interests of the Clinical Department. To participate in the Management / Medical Audit requirements of the Department in liaison with other colleagues in line with the University Health Board policy on the implementation of Clinical Governance. To undertake administrative duties associated with NHS clinical activities. To comply with NHS Policies / Procedures for Internal Financial Management. To participate in continuing medical education in ways which are acceptable to the Chief Executive.

 To participate in the Joint Appraisal Process. All Clinical staff are required to hold appropriate professional indemnity from one of the medical protection organisations in respect of clinical activity.  To take reasonable care for the health and safety of yourself and of other persons who may be affected by your acts or omissions at work in accordance with the Health and Safety at Work Act 1974, EC directives and the University’s Safety, Health and Environment Policies and procedures and to cooperate with the University on any legal duties placed on it as the employer. As a member of staff with managerial/supervisory responsibilities you will also be responsible for ensuring that University policy and procedures and legal duties are applied within your areas and that appropriate risk assessments are undertaken, necessary actions are implemented and staff within your area are fully conversant and trained in respect of their Health and Safety obligations.  To ensure compliance with legal and regulatory requirements in respect of equality and diversity, data protection, copyright and licensing, security, financial and other University policies, procedures and codes as appropriate.  You may be asked to perform other duties occasionally which are not included above, but which will be consistent with the role.

Role and Person Specification The School requires the appointee to ensure delivery of the research, teaching and managerial requirements placed on Haematology. It is expected that the appointee will bring a national/international reputation in basic and/or applied research in haematology, including work on treatment development and translational medicine; there is a particular expectation that he/she will continue to provide leadership in Haematological malignancy within the UK. This will consist of support for the longstanding Cardiff role as UK lead for clinical trials in haematological malignancy (AML), and also for the introduction of new treatments through pre-clinical and early phase clinical trials. Research need not be restricted to haematological malignancies and collaborative work with colleagues working on solid tumours and basic mechanisms will be encouraged. It is anticipated that the appointee will play a prominent role in the ECMC with the prospect of leading the haematological component. It is expected that the appointee will be a major force in the further development of the Clinical Research Facility. He/she will help optimise the success of the existing research staff in Haematology, whether by internal focus, or collaboration within and across Schools of the University and the UK and internationally.

The Service Role The appointee can expect to be involved in advisory roles in the NHS in Wales. His or her role in maintaining the integrated provision and development of both clinical and laboratory services is seen as crucial. On a personal level, the appointee will be expected to contribute to the clinical service via outpatient/day case and inpatient service as outlined in the NHS section. The clinical and laboratory services within the Cardiff and Vale University Health Board represent an invaluable partner in the development of translational medicine and clinical research, where collaboration with NHS colleagues has been a strong tradition. This partnership is evident from aligned R&D strategies and shared R&D Office and Lead.

Person Specification Essential Criteria Expertise/Competence/Skills 1. Ability to lead and direct a high profile research programme. 2. Proven ability to attract research grant funding. 3. Proven track record of high impact publication. 4. Ability to deliver teaching at undergraduate & postgraduate level. Knowledge 5. Demonstrable knowledge of clinical governance. 6. Demonstrable knowledge of research governance. 7. Demonstrable knowledge of good clinical practice criteria. Qualifications (IT/Academic/Vocational) 8. Full General Medical Council Registration (or eligibility for registration). 9. Licence to practise in UK (or eligibility to obtain licence) 10. CST in Haematology (or be within 3 months of obtaining CST) or equivalent. 11. On the Specialist Register in Haematology (or be eligible for or within 6 months of eligibility for inclusion). 12. Fellowship of Royal College of Pathologists (FRCPath), or equivalent. 13. A PhD/MD in relevant area. Experience 14. Team leadership in relevant research area. 15. Previous experience of supervising research staff and students. 16. Broad clinical experience in Haematology. Desirable Criteria 17. Experience in developmental therapeutics and trial design. Important Note: An honorary consultant contract will be requested from Cardiff and Vale University Health Board (UHB). Please note that in order to obtain an honorary clinical contract with the relevant UHB, the successful candidate must comply with the UK Health Department’s guidance on protecting health-care workers and patients from Hepatitis B. In addition, the successful candidate must hold appropriate professional indemnity from one of the medical protection organisations in respect of clinical activity.

Applicants who have completed their training outside of the UK should demonstrate equivalence to the 5 years’ minimum training period in the National Health Service required to gain an honorary consultant contract.

School of Medicine Mission The mission of the School of Medicine is to pursue the highest standards of research, education and training, in medicine and related subjects, so as to enhance the health and wealth of the people of Wales and the wider world. Profile The School of Medicine at Cardiff is one of the largest in the UK, employing nearly 500 academic and 300 support staff with over 1000 undergraduate and 1100 postgraduate students currently enrolled on medical and science courses. The School has an annual financial turnover of over £50M of which nearly half comes from competitive external research funding. Teaching The School of Medicine delivers a 5 year undergraduate programme for medical students in conjunction with the School of Biosciences and the NHS in Wales. The course admits about 300 students to year 1, with some graduates entering via feeder courses from Medical Pharmacology and University of Glamorgan directly into year 2. All students follow an integrated curriculum, blending biomedical sciences, pathological sciences and clinical experience. Teaching is delivered using lectures, small group teaching, clinical skills laboratories and simulation suites. Students gain clinical experience from year 1 in a wide variety of settings, including general practices and hospitals throughout Wales. This is an exciting time of development in the undergraduate programme as we seek to ensure that all our students achieve the learning outcomes required in the GMC’s document, ‘Tomorrows Doctors-2009’. With the appointment of Professor John Bligh as the Dean of Medical Education we are developing a new course (C21 project) for the student intake in September 2013. This will offer enhanced clinical experience from year 1, small group learning based around key clinical cases, community based learning and extensive hospital experiences. Students will also be encouraged to engage in research activities and clinical projects. The School of Medicine encourages both non-clinical and clinical staff to be involved with teaching and training of medical students by delivering teaching, supervising research projects for students and intercalating students and acting as a personal tutor. The School is also the largest provider of taught, medically related postgraduate courses in the UK and these are delivered as distance learning or part-time courses. Many disciplines are involved and there are several unique and innovative courses.

Further information about the undergraduate course can be found on Learning Central and School of Medicine website and if you would like to be involved please contact: Helen Sweetland, Vice Dean of Medical Education ([email protected]) Research Research in the School is in a period of flux, longstanding interdisciplinary themes, spanning the spectrum from basic science to clinical practice, maturing into five Research Institutes that will launch in autumn 2011: • Infection, Immunity & Inflammation • Public Health • Metabolic and Experimental Medicine • Cardiovascular Sciences • Neuropsychiatric and Neurology • Cancer and Genetics All five Institutes are producing forefront international research, and total research awards in 2009/10 exceeded £70m. Further information can be found via: http://medicine.cf.ac.uk/en/research The Research Institutes are supported by cross-cutting Institutes of Medical Education and Translation, Innovation and Methods.

Innovation and Engagement Innovation & Engagement (I&E) supports and enhances the traditional academic domains of learning and teaching and research. The activity is broad ranging and impacts positively on the School and those who we interact with. In 2009, the School implemented an I&E strategy with the following three aims. • To be recognized as a Centre of Excellence for collaboration, knowledge transfer and translational innovations. • To maximize the opportunities arising from internationally acclaimed academic expertise to inform public policy and services across the health and social sector locally and globally • To build a repository of evidence based research, information and advice accessible to national international health service providers and the wider public Through our I&E activity the School is committed to engaging with the public on a number of different levels. A short list of examples include: • Collaborating with industrial partners • Providing public access to facilities • Contributing to the shaping of new polices • Developing collaborative community based research programmes responsive to community identified needs • Organising initiatives designed to increase the public understanding of science in health • Pursuing strategic international links

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Supporting student led I&E activities

For further information on the School’s I&E activities please visit: http://medicine.cf.ac.uk/en/innovation-engagement/ Details of the Public Understanding of Science in Health group can be at the following address: http://www.cardiff.ac.uk/medicine/push Should you wish to get involved in the School’s I&E activity or wish to share an engagement idea, please contact Sarah Hatch, Innovation and Engagement Manager [email protected] Location The School of Medicine is largely based on the Heath Park Campus of Cardiff University alongside the University Hospital of Wales. Teaching is also carried out in the neighbouring Cathays Campus (School of Biosciences) and the second teaching hospital in Cardiff at Llandough.

Academic Haematology

An ongoing reconfiguration within the School will incorporate the Department of Haematology into the Institute for Cancer and Genetics, although some members may be included in other Institutes. The identity of the Department will be retained in this new managerial entity and the Department Head (The Professor) will be expected to provide leadership for the subject area in the context of the Institute. Staff of the Department of Haematology contribute to all facets of the medical course and also make contributions to the teaching of dental undergraduates, course organisation/admissions/assessment and student welfare. Since its inception the Department has had a major interest in Haematological malignancy. Senior academic staff also participate in haemostasis and haemoglobinopathy research. Over many years the Academic and Service components of Haematology have been closely integrated and provided leadership in both spheres in Wales, the UK and beyond. Haematology staff make a major contribution to the leadership and development of Trials in Acute Myeloid Leukaemia in the UK and this, with associated translational research, is an important component of the School’s Cancer portfolio. Because of its record in spanning basic and clinical research, and in particular bringing novel treatments to national randomised trial, the Department hosts part of the CRUK’s Cardiff Experimental Cancer Medicine Centre, and has recently been successful in establishing ongoing funding for the “Pick a Winner” drug development programme for AML from the Leukaemia and Lymphoma Research. The Department is one of the UK leaders in basic and clinical research in haematological malignancies and was earmarked as internationally outstanding in this area in the 2008 RAE. This activity focuses on leukaemia, and spans basic research through to leadership of large multicentre, multinational clinical trials. Over the last 4 years staff have been successful in obtaining in excess of £17m of grant income from various sources including the MRC, WORD, CRUK, LRF, Leukaemia Research Appeal for Wales and the pharmaceutical industry, and have published around 150 articles in this period. The clinical trial work is supported by the University as Sponsor, and the Departmental Trials Unit.. We have recently been awarded CRUK centre status and haematological research is a key component of this centre. This centre award includes a separate chair in clinical oncology, plus clinical and nonclinical fellowships. The Department was the first to be designated by Leukaemia and Lymphoma Research as a “Centre of Excellence”.

The Department of Haematology The main research focus of the Department is in haematological malignancy. The lab programme in Chronic Lymphocytic Leukaemia is led by Dr C Pepper and in Myeloid Malignancy by Drs Darley and Tonks.

Departmental Staff Professor and Head:

This Post (0.6 School)

Professors:

P Collins (0.5 School, 0.5 NHS) Haemophilia Director: Haemostasis Research C Pepper (0.8 School: 0.2 NHS) – non clinical

Readers:

R Darley (1.0 School) – non clinical R K Hills (1.0 School) – translational Statistician

Senior Lecturers:

S Knapper (0.5 School: 0.5 NHS) Clinical translational research K Wilson (1.0 NHS) Director of Transplant Service C Alvares (0.5 School; 0.5 NHS)

D Bowen (1.0 NHS) – Non Clinical Haemostasis Research A Tonks (School) (1.0 School) Myeloid Malignancy Other Scientific Staff:

A May (NHS) Haemoglobinopathy Service A Gilkes (School) Gene Expression/Molecular Screening P White (School) Cell Bank M Sweeney (0.6 NHS)

Departmental Secretariat: S Edwards (1.0 School) C Rabaiotti (0.5 School) (figures in parenthesis represent funding source) Non-tenured Staff:

20 other non-tenured staff including 8 clinical trials staff and 6 ECMC scientists.

Co-incidental with the appointment of the Professor will be the appointment of 1 Non-Clinical Senior Lecturer post.

Relevant Facilities within the School There are a number of units and organisational structures within the School in which the appointee will be encouraged to participate or can support him/her in the role. Laboratory Accommodation The Academic Department is located on the 7 th Floor comprising 3,500sq ft of lab space and office space for 44 individuals. This has recently undergone renovation. On the 6th Floor a further 3 offices which can accommodate up to 10 staff are allocated to the Haematology Cancer Trials Office, which is a component of the Cardiff University Haematology Clinical Trials unit (Head: Dr R Hills). Institute of Cancer and Genetics:

Chairs: Profs.J Chester & J Sampson

Cancer research in the medical school has to date been co-ordinated and driven via the Cancer Studies Interdisciplinary Research Group, now the Institute of Cancer and Genetics. This IRG encompasses researchers from several departments and they cover basic, translational and clinical cancer research (http://www.cf.ac.uk/medic/research/irgs/cancer/). This highly successful group of 28 academics has over £47M in current research income, while 66% of its publications were deemed internationally excellent in the 2008 UK Research Assessment Exercise. In autumn 2011, the IRG will evolve into a Research Institute. Experimental Cancer Medicine Centre (ECMC) (Leads: Prof Alan Burnett/ Prof J Chester) The Centre was initiated in 2007 as part of a UK wide initiative to facilitate clinical trial development. Cardiff receives a flexible budget of £285k pa from Cancer Research UK. The initiative is initially planned for 5 years with annual renewal and was renewed in 2012-2017. At present the centre supports the IRG management, and employs 8 cancer scientists. They undertake the following functions within Haematology: Molecular Screening for national AML trials; in vitro assessment of new agents for leukaemia; development of new bioassays; screening novel agents.; quality assurance and tissue banking (The AML Trial Bank).

Clinical Research Facility (CRF)

(Lead: Prof Chris Fegan)

The Clinical Research Facility (CRF) is a component of a successful Wellcome/Joint Infrastructure Fund bid. It provides a crucial facility for the translation of basic biomedical science developments into clinical practice. The CRF provides a high quality clinical environment in which patients can undergo research programmes safely and effectively according to scientifically robust, ethically approved studies, including both clinical trials and other forms ofclinical investigation. The CRF currently hosts studies from Phase 1 therapeutic studies through

Phases 2, 3 and 4; MRC cohort studies and non commercial, commercial and grant funded work.

The CRF has a 10 bed ward area with full patient monitoring and access to support from the NHS emergency team, ITU and Anaesthetics. Normal opening hours are 8am to 5pm Monday to Friday but the CRF can provide overnight stays as required for Phase 1 studies. Nursing and patient booking support for studies can be negotiated at many levels as required. Wales Cancer Bank; Lead: Prof Malcolm Mason The Wales Cancer Bank (WCB) aims to be a population based bank of tissue and blood samples from all patients in Wales undergoing surgery to remove tissue where cancer is a possible diagnosis. The bank will provide a valuable resource to cancer researchers worldwide and help move towards the goal of personalised medicine. WCB has NRES approval to collect, store and issue biomaterials and is licensed under the Human Tissue Act (2004) to store human tissue for research. The bank currently collects in seven hospitals around Wales and has consented just over 2,800 patients in the last four years. This equates to around 40,000 individual samples of tumour and normal tissue (frozen and paraffin embedded), serum, EDTA bloods, DNA from blood, DNA and RNA from tissue, and blood from a spouse, partner or friend of the patient. All tissue samples have associated pathology quality assurance data and nucleic acids have relevant molecular biology quality assurance data. Clinical treatment and outcome data is also collected and associated with the biological samples to provide a complete data set wherever possible. Access to the samples which does not include leukaemia, is open to all researchers involved in cancer related research and all applications to the bank are reviewed for scientific merit by an international, external review panel. All samples are reviewed to ensure quality before releasing to researchers under a Material Transfer Agreement. Forty two applications have been made to WCB from the UK and Europe and, to date, twenty three of those have been supplied with samples. In Cardiff WCB collects urology samples in UHW and colorectal and gynae samples in Llandough. Two BMS posts are located in Cardiff, one of which is funded by the ECMC grant and is available to help facilitate ECMC related tissue research as well as the core activities for WCB.

Wales Cancer Trials Unit (WCTU)

Acting Director – Dr Rob Jones

The Wales Cancer Trials Unit is dedicated to improving clinical practice through quality research evidence. The WCTU is a one stop shop for a clinical trial, from the basic idea, to producing reliable evidence to change practice. The WCTU is a National Cancer Research Institute (NCRI) accredited and UKCRC registered Clinical Trials Unit and receives core

funding from Cancer Research UK and Marie Curie Cancer Care. It is part of a reconfigured Cardiff University Clinical Trial Organisation.

Although based in Cardiff, it works with clinicians and cancer investigators from any area in the UK to develop trial ideas that are then run and coordinated by the WCTU staff who comprise a range of experts including Statisticians, Clinicians, Qualitative Researchers, Trial Managers, Data Managers, IT / Programmers, Safety Officers and a Quality Assurance Manager. These staff work with Oncologists, Palliative Care Clinicians and research groups wishing to develop clinical trials or other well designed studies. Proposals for trials are submitted to an appropriate funder, e.g. Cancer Research UK, to consider for funding and if judged to be asking good scientific questions and designed well, it is likely that WCTU will be funded to run the trial. From this point the team at the WCTU will manage all trial procedures working closely with the lead researcher.

Central Biological Sciences (CBS) Lead Prof Nick Topley Central Biotechnology Services (CBS) was set up to provide a cost-effective state-of-the-art biotechnology service with a “one-stop shop” for advice / training / analysis for School of Medicine researchers. Since the merger with Cardiff University in August 2004, infrastructure funding has enabled CBS to expand and improve the services offered; the emphasis being on easily accessible, cost effective, well supported technical services including proteomics, flow cytometry, genomics, histology and confocal microscopy. CBS is a central “core” facility, dedicated to furthering the research and educational needs of Cardiff University and its surrounding community. This it achieves by providing efficient, high throughput laboratory facilities and technical support, enabling the acceleration of research activities, the fostering of collaborations and the realisation of the Universities research potential. The long-term objective of CBS is to provide an excellent, costeffective service, offering advice, training and analysis using facilities across the broad spectrum of the life sciences. For further details about CBS please visit the website: http://www.cardiff.ac.uk/medic/cbs/