Stand: 06.05.2013

I. International Conference of Collaborative I. International Conference of Collaborative Research Research Center SFB 974 Center SFB 974 “Liver Damage and Regeneration”

November 15th and 16th 2013 November 15th and 16th 2013 Heinrich-Heine-University, Düsseldorf Heinrich Heine University, Düsseldorf

Program Program Friday, November 15th, 2013 08.45 – 09.00 Welcome Dieter Häussinger, Head of the Collaborative Research Center SFB 974  Session I Liver regeneration: General aspects Chair: Neil Theise 09.00 – 09.30 Regenerative responses to liver injury George Michalopoulos (Pittsburgh, USA) 09.30 – 09.50 Endothelial cell-derived signals in liver development and regeneration Eckhard Lammert (Düsseldorf, Germany) 09.50 – 10.10 Growth factor signalling in liver regeneration Philippe Bastiaens (Dortmund, Germany) Chair: George Michalopoulos 10.10 – 10.30 Liver regeneration mediated by lymphotoxins and tumor necrosis factor Klaus Pfeffer (Düsseldorf, Germany) 10.30 – 11.00 Coffee Break 11.00 – 11.30 Developmental morphogens and adult liver repair Anna Mae Diehl (Durham, USA) 11.30-11.40 Poster Presentation  Session II Liver regeneration: Role of stem cells Chair: Dieter Häussinger 11.40 – 12.10 Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production? Neil Theise (New York, USA)

12.10 – 12.30 Stellate cells as mesenchymal stem cells Dieter Häussinger and Claus Kordes (Düsseldorf, Germany) 12.30 – 13.00 Regulation of Wnt signaling Christof Niehrs (Mainz, Germany) 13.00 – 14.00 Lunch Chair: Lenhard Rudolph 14.00 – 14.30 Wnt signaling, Lgr5 stem cells and cancer Meritxell Huch (Utrecht, The Netherlands) 14.30 – 14.50 Human induced pluripotent stem cell-based modeling of hepatogenesis James Adjaye (Düsseldorf, Germany) 14.50-15.00 Poster Presentation  Session III Liver Regeneration: Systems and structural biology approaches Chair: Eckard Lammert 15.00 – 15.25 Towards multi-scale quantiative models of liver regeneration Dirk Drasdo (Paris, France) 15.25 – 15.35 Coffee Break 15.55 – 16.20 Bridging the scales in liver regeneration) Ursula Klingmüller (Heidelberg, Germany) 16.20– 16.45 Integrated spatial-temporal and metabolic modeling of ammonia detoxification Jan G. Hengstler (Dortmund, Germany)

15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf

Program Program Chair: Ursula Klingmüller 16.45 – 17.05 Multiparameter fluorescence spectroscopy analyses the fundamental role of conformational flexibility for the control of protein function within a cell(20 min) Claus Seidel (Düsseldorf, Germany) 17.05 – 17.25 Effectors of integrin activation Holger Gohlke (Düsseldorf, Germany) 17.25 – 17.50 RNAi based dissection of proliferation control in liver regeneration and liver cancer Lars Zender (Tübingen, Germany) 17.50-18.00 Poster Presentation

Event and Dinner for Speakers

Individual poster presentations will be accessible in the lobby during the whole conference.

15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf

Program Program Saturday, November 16th, 2013  Session IV Liver damage, regeneration and cancer development Chair: Christof Niehrs 09.00 – 09.25 New mechanisms involving the EGFR and FGF15/19 systems in liver regeneration and carcinogenesis Matìas Avila (Pamplona, Spain) 09.25 – 09.55 The role of the bile acid receptor TGR5 in liver damage and regeneration Verena Keitel (Düsseldorf, Germany) 09.55 – 10.15 Transport dysfunction as a cause of liver failure. Ralf Kubitz (Düsseldorf, Germany) Chair: Matìas Avila 10.15 – 10.35 In vitro investigations of ABC transporters of the human liver - advantages and surprises Lutz Schmitt (Düsseldorf, Germany) 10.35-11.05 Coffee Break 11.05 – 11.25 Molecular mechanisms of cirrhosis and hepatocarcinogenesis K. Lenhard Rudolph (Jena, Germany)

 Session VI Hepativ immunity (and beyond) Chair: Anna Mae Diehl 13.00 – 13.25 Modulation of the inflammatory response by Lipoprotein Receptors Petra May (Düsseldorf, Germany) 13.25 – 13.45 Role of MK2/MK3 in inflammation and the acute phase response Johannes Bode (Düsseldorf, Germany) Chair: Percy Knolle 13.45 – 14.05 Immune functions during chronic viral infections Philipp Lang (Düsseldorf, Germany) 14.05 – 14.25 On the role of enforced virus replication in autoimmune disease Karl Lang (Essen, Germany) 14.25-14:33 Poster Presentation

Concluding remarks Dieter Häussinger (Düsseldorf, Germany) End of the conference

Individual poster presentations will be accessible in the lobby during the whole conference.

11.25 – 11.55 Mechanisms determining hepatic immunity and tolerance Percy Knolle (Bonn, Germany) 11.55-12.03 Poster Presentation

Snack 12.00-13.00

15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf

Speakers and Chairs List of Speakers and Chair Prof. Dr. James Adjaye Institut für Stammzellforschung und Regenerative Medizin Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Matías Avila Division of Hepatology and Gene Therapy CIMA. University of Navarra Avda. Pio XII, n55. 31008 Pamplona, Spain [email protected] Prof. Dr. Philippe Bastiaens Department of Systemic Cell Biologie Max Planck Institut of Molecular Physiology Otto-Hahn-Str. 11 44227 Dortmund [email protected] Prof. Dr. Johannes Bode Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Dr. Anna Mae Diehl Department of Medicine, Duke University DUMC 3913 Durham, NC 27710 USA [email protected] PD Dr. Dirk Drasdo Interdisciplinary Center for Bioinformatics University of Leipzig Härtelstr. 16-18 D-04107 Leipzig [email protected] Prof. Dr. Holger Gohlke Institut für Pharmazeutische und Medizinische Chemie Heinrich-Heine-Universität Universitätsstraße 1 40225 Düsseldorf [email protected] Prof. Dr. Dieter Häussinger Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected]

Professor Dr. Jan G. Hengstler Leibniz-Institut für Arbeitsforschung an der TU Dortmund Ardeystraße 67 44139 Dortmund [email protected] Dr. Meritxell Huch Hubrecht Institute for Developmental Biology and Stem Cell Research 3584 CT UTRECHT The Netherlands [email protected] PD Dr. Verena Keitel Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Dr. Ursula Klingmüller German Cancer Research Center Systems Biology of Signal Transduction A150 Im Neuenheimer Feld 280 69121 Heidelberg [email protected] Prof. Dr. Percy Knolle Institut für Molekulare Medizin Universitätsklinikum Bonn (AöR) Sigmund-Freud-Str. 25 D-53127 Bonn [email protected] Dr. Claus Kordes Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Dr. Ralf Kubitz Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Dr. Eckard Lammert Institut für Stoffwechselphysiologie Heinrich-Heine-Universität Universitätsstraße 1 Gebäude: 26.12 40225 Düsseldorf [email protected]

15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf 15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf

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Speakers and Chairs List of Speakers and Chair Prof. Dr. med. Karl Lang Institut für Immunologie Universität Duisburg-Essen Medizinische Fakultät Hufelandstr. 55 D-45147 Essen [email protected] PD Dr. Philipp Lang Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected] Prof. Dr. Petra May Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf MNR-Klinik Moorenstrasse 5 40225 Düsseldorf [email protected]

Prof. Dr. Claus Seidel Institut für Physikalische Chemie II Heinrich-Heine-Universität Universitätsstraße 1 40225 Düsseldorf [email protected] Prof. Dr. Neil Theise Division of Digestive Diseases Beth Israel Medical Center First Avenue at 16th Street New York NY 10003 USA [email protected] Prof. Dr. Lars Zender Abteilung für Molekulare Onkologie solider Tumore Innere Medizin I Universitätsklinikum Tübingen Otfried-Müller-Strasse 10 72076 Tübingen [email protected]

Prof. Dr. George Michalopoulos Department of Pathology University of Pittsburgh School of Medicine 410 South BST Pittsburgh PA 15261, USA [email protected] Prof. Dr. Christof Niehrs Institut für Molekulare Biologie IMB Ackermannweg 4 55128 Mainz Germany [email protected] Prof. Dr. Klaus Pfeffer Institut für Medizinische Mikrobiologie und Krankenhaushygiene Universitätsstraße 1 Gebäude: Gebäude: 16.11 Heinrich-Heine-Universität 40225 Düsseldorf [email protected] Prof. Dr. K. Lenhard Rudolph Leibniz-Institut für Altersforschung - Fritz-Lipmann-Institut e.V. (FLI) Beutenbergstraße 11 D-07745 Jena [email protected] Prof. Dr. Lutz Schmitt Institut für Biochemie Heinrich-Heine-Universität Universitätsstraße 1 40225 Düsseldorf [email protected] 15th and 16th of Nov 2013• seminar room, building. 13.57, 2. floor • Moorenstr. 5 • 40225 Duesseldorf

Registration andand Contact List of Speakers ChairInformation Registration Please use our registration form available by QR-code, URL or our website until 16th of September 2013. Registration form

Child Care during Symposium In cooperation with the Heinrich Heine University we offer professional Child Care during the Symposium. Please use our registration form available via Link or QR-Code.

http://www.uni-duesseldorf.de/sfb974/machforms/view.php?id=9488

web site htpp://www.uni-duesseldorf.de/sfb974

Contact For any further questions, please contact: SFB 974, Dr. Nora Luniak Clinic for Gastroenterology, Hepatology, and Infectious Diseases Moorenstrasse 5 40225 Düsseldorf Tel.+49-211-81-18941, Fax +49-211-8104847 [email protected] htpp://www.uni-duesseldorf.de/sfb974

Please scan QR-Code for direct link to our registration form

Location/map

15th and Novof2013• seminar room,room, building. 13.57,13.57, 2. floor Moorenstr. 5 • 40225 Duesseldorf 15th16th and of 16th Nov 2013• seminar building. 2. •floor • Moorenstr. 5 • 40225 Duesseldorf

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