Jeremy J. Johnson, PharmD, PhD Assistant Professor University of Illinois at Chicago College of Pharmacy Department of Pharmacy Practice 833 South Wood Street, Room 117B Chicago, IL 60612-7230 Tel (312) 996-4368 [email protected] EDUCATION 1997 - 2001

Bachelor of Science (B.S.) University of Wisconsin-Stevens Point Biology Major/Chemistry Minor

2003 - 2007

Doctor of Pharmacy (Pharm.D.) University of Wisconsin School of Pharmacy Major: Pharmacy 2006 Pharmacy Internship, Froedtert Memorial Lutheran Hospital, Milwaukee, WI

2007 - 2010

Doctor of Philosophy (Ph.D.) University of Wisconsin - Comparative and Biomedical Sciences Emphasis: Cancer Chemoprevention / Translational Research Thesis title: Selected plant constituents for the prevention and treatment of prostate cancer

LICENSE / CERTIFICATIONS: 2007 - Present Registered Pharmacist (R.Ph.) – State of Wisconsin (Active) License: 15101-040 (October 2007) State of Illinois (Active) License: 051294759 (March 2011) 2009 - Present

Certificate: Pharmacy-Based Immunization Delivery (APHA)

EMPLOYMENT HISTORY 1999 - 2001 Undergraduate Researcher, Biology Department, UW-Stevens Point, Stevens Point, WI 2000 Research Assistant, Ortho Molecular Products, Inc., Stevens Point, WI. 2001 - 2002 Associate Research Specialist, Department of Medical Microbiology and Immunology, UWMadison, Madison, WI 2003 Research Specialist, Department of Medical Microbiology and Immunology. UW-Madison, Madison, WI. 2003 - 2004 Project Assistant, Department of Medical Microbiology and Immunology, UW-Madison, Madison, WI 2006 - 2007 Project Assistant, Department of Dermatology, UW-Madison, Madison, WI 2007 - 2008 Assistant Scientist, Center for Women’s Health Research, UW-Madison, Madison, WI 2007 - 2010 Staff Pharmacist. Walgreens. 2008 - 2010 Assistant Scientist. University of Wisconsin School of Pharmacy, Division of Pharmacy Practice 2009 - 2010 Clinical Instructor. University of Wisconsin School of Pharmacy 2010 – Present Member. University of Illinois at Chicago Cancer Center 2010 – Present Clinical Pharmacist. University of Illinois at Chicago 2010 – Present Assistant Professor. Department of Pharmacy Practice, University of Illinois at Chicago, College of Pharmacy 2012 – Present Core Leader – Preclinical Development/Pharmacokinetics. UIC Collaborative Engagement in Novel Therapeutic Research and Enterprise (UI-CENTRE).

PI: Johnson, Jeremy

4/2/2015

MEMBERSHIPS / AFFILIATIONS: 2007 – Present AACR (American Association of Cancer Research) 2011 – Present ACCP (American College of Clinical Pharmacy) 2013 – Present PSNA (Phytochemical Society of North America) 2013 – Present ASPET (American Society of Pharmacology and Experimental Therapeutics)

AWARDS & HONORS 2001 2004 2007 2007 - 2010 2008 2009 2015

UWSP – Dean’s Distinguished Achievement Award Merck Pharmacy Student Research Travel Award TEAM Scholar, UW-Madison CTSA Scholar, UW-Madison Susan G. Komen AACR Scholar-In-Training Award (Frontiers in Cancer Prevention Research, November 16-19th, National Harbor MD) Susan G. Komen AACR Scholar-In-Training Award (Frontiers in Cancer Prevention Research, December 6-9th 2009, Houston TX) Hans W. Vahlteich UIC Research Scholar

EDITORIAL BOARDS: 2013 – Present 2013 – Present

Associate Editor - American Journal of Cancer Biology Associate Editor - American Journal of Cancer Therapy and Pharmacology

COMMITTEES/SERVICE Journal Referee: Canadian Journal of Physiology and Pharmacology, Carcinogenesis, Cancer Letters, Cancer Research, Clinical Cancer Research, Environmental Toxicology and Pharmacology, International Journal of Cancer, Journal of Nutrition, Investigational New Drugs, Journal of Proteome Research, Journal of Food Science, Life Sciences, Molecular Nutrition and Food Research, Molecules, Nutrition Research, Journal of Steroid Biochemistry and Molecular Biology, PLOSone, Arabian Journal of Chemistry, Journal of Nutritional Biochemistry, European Journal of Drug Metabolism and Pharmacokinetics, Biomedical Chromatography, Nutrients, Molecular Cancer, Committees and University Service: 2008 – 2009 UW School of Pharmacy Student/Faculty/Staff Relations 2010 UIC College of Pharmacy Strategic Planning – Department of Pharmacy Practice: Scholarship working group (11/16/2010) 2011 Reviewer for the David J. Riback Research Pre-doctoral Fellowships 2011 Judge for the College of Pharmacy Research Days 2011 2012 Reviewer for the David J. Riback Research Pre-doctoral Fellowships 2012 Judge for the College of Pharmacy Research Days 2012 2013 Reviewer for the David J. Riback Research Pre-doctoral Fellowships 2013 Judge for the College of Pharmacy Research Days 2013 2015 Judge for the College of Pharmacy Research Days 2015 2011 – Present UIC College of Pharmacy – Committee of Committees 2012 – Present UIC Faculty Senate – Senator 2013 – Present Organization and Administration Committee (ACPE Self Study)

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Graduate Student Committees: PhD Students: 1. Shangwen Luo (Pharmacognosy PhD Student) – Committee Member 2. Dede Ekoue (Pathology PhD Student) – Committee Member 3. Guanan Li (Medicinal Chemistry PhD Student) – Committee Member MS Students: 1. Saba Berhe (Pharmacy MS Student – University of Basel) – Primary Research Mentor

Study Section (Scientist Reviewer): 2008 Veteran Affairs (VA) Clinical Trials Study Section – Cancer Chemoprevention (Ad hoc) 2010 Czech Science Foundation (Ad Hoc) 2010 - Present Department of Defense (DOD) Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program (PCRP) 2010 PCRP Prostate Cancer Training Award 2 2011 PCRP Training-Detection and Experimental Therapeutics 2011 PCRP Pre-application - Clinical and Experimental Therapeutics-3 2012 PCRP Training-Detection and Experimental Therapeutics 2012 PCRP Pre-application-Clinical and Experimental Therapeutics-1 2013 PCRP Pre-application-Clinical and Experimental Therapeutics-1 2013 PCRP Pre-application-Exploration-Hypothesis Development-Clinical and Experimental Therapeutics-1 2014 PCRP Pre-application-Exploration-Hypothesis Development-Clinical and Experimental Therapeutics-1 2014 PCRP Training - Pathobiology 2013 - Present Department of Defense (DOD) Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (PCRP) 2013 BCRP Epidemiology and Prevention 2015 BCRP Epidemiology and Prevention Conference Committee 2014 53rd Annual Meeting of the Phytochemical Society of North America (Raleigh, NC) August 9-13th Organizing Committee – Chair of Botanical Medicine Symposium UW Chemoprevention Program (2007-10): The members of this Program collaboratively pursue basic laboratory studies seeking potential agents to intervene in neoplastic development; translational and population-based studies to identify at-risk populations and measures of benefit; and clinical trials to determine the validity of biomarkers and the effectiveness of chemopreventive agents. Involvement includes a bi-weekly meeting with members of the chemoprevention program to discuss ongoing Phase I-III clinical trials at UW as well as discuss future proposed clinical trials. These meetings discuss progress on accrual rate, clinical events of participants, and protocol amendments. UI CENTRE (2013 - Present): The UI-CENTRE (University of Illinois Collaborative Engagement for Novel Therapeutics Research Enterprise) is a campus wide initiative to promote collaboration across many disciplines to encourage the development of novel therapeutics for a wide variety of disease states. The UI-CENTRE is comprised of 5 cores that include administration (Core 1), Medicinal Chemistry (Core 2), Drug Library Development (Core 3), High Thru put screening (Core 4) and Pre-clinical Pharmacokinetics (Core 5). The pharmacokinetics core that I lead is responsible for the development of LC/MS-MS assays capable of detecting small molecules for in vitro studies (e.g. plasma stability and microsomal assays) and in vivo studies (e.g. mouse pharmacokinetics including plasma/serum and tissue). Role: Core 5 Leader

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TEACHING 2008 - 2009 2008 - 2009 2009 - Present 2008 - 2009 2009 - 2010 2009 - 2010 2011 - Present 2011 - Present 2013 - 2014 2013 - Present 2015 – Present

School of Pharmacy, Pharmacotherapy lab Fall: Chronic Kidney Disease, Anemia, Solid Organ Transplant, Nutrition, Immunizations Spring: Chemoprevention, Palliative Care, Lipids, HIV/AIDS anti-viral College of Letters and Science, Mentor for Undergraduate Research Scholar (URS) program School of Pharmacy, Mentor for 3rd/4th year PharmD candidate in independent study (699) and 4th year clerkship College of Letters and Science, Mentor for Independent Research Project (Biology 154: Introduction to Zoology) Lecture, Pharm Prac 672 “Herbals, Homeopathy, and Dietary Supplements” – lecture on natural products for cancer chemoprevention Lecture, Pharm Prac “Over the Counter Medications” – Lectures on vitamins and minerals BPS/MDCH/PMPG 553 “Cancer biology and therapeutics” –Natural products for cancer chemoprevention – focus on pre-clinical mechanism of action Phar365 “Nonprescription pharmaceuticals and herbal medicinals” – Dietary supplements: Regulation and Quality, Cardiovascular, Chemoprevention, and Men’s Health. PMPR 355 “Seminar in Pharmacy Research” – Chemoprevention in Prostate Cancer. BPS/MDCH/PMPG 507 “Drug Discovery, Design and Development” - History and Future of Drug Development in Cancer Chemoprevention PMPR 355 “Seminar in Pharmacy Research” – Course Coordinator

CLINICAL PROTOCOLS / TRIALS Active / IRB Approved: 1. A phase 1 clinical trial to evaluate the pharmacokinetic profile of a dietary supplement containing αmangostin in healthy adult volunteers ClinicalTrials.gov: IRB approved, Not Recruiting PI: Johnson JJ Site: University of Illinois at Chicago Role: Protocol Chair / Pharmacokinetic Assay Development and Analysis Summary: The purpose of this to study is to see if a mangosteen extract when given orally is absorbed and the main phytochemical can be detected in blood. Participants will receive one dose of 1000 mg of a Mangosteen Extract (containing 20% α-mangostin) with a meal. Blood will be collected at 15 minutes, 30 minutes and 1, 2, 4 , 6, 8, 12 and 24 hrs. The level of α-mangostin will be determined at each time point. 2. Resveratrol with or without piperine to enhance plasma levels of resveratrol ClinicalTrials.gov: NCT01324089 PI: Howard Bailey, MD Site: University of Wisconsin Role: Pharmacokinetics analysis Summary: The purpose of this study is to see if resveratrol in combination with piperine is more effective than taking resveratrol alone. Since investigators don't know what dose of piperine to use in combination with resveratrol, two different doses of piperine will be studied. Twenty-four participants, equal numbers of males and females, will receive a single dose of resveratrol (2.5 grams) without piperine, resveratrol (2.5 grams) with piperine (5 mg), or resveratrol (2.5 grams) with piperine (25 mg). 3. A Biological Study of Resveratrol's Effects on Notch-1 Signaling in Subjects With Low Grade Gastrointestinal Tumors ClinicalTrials.gov: NCT01476592 PI: Emily Winslow, MD Site: University of Wisconsin Role: Pharmacokinetic Assay Development and Analysis Summary: The purpose of this study is to examine the effects of resveratrol and Notch-1 on neuroendocrine tumor tissue and to examine how people with neuroendocrine tumors who take resveratrol for up to three months tolerate the product

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MENTORING Total: 24 Post-doctoral Fellows / Scientists: 6 Pharmacy Students: 3 Medical Student: 2 PhD Students: 4 MS Students: 1 Undergraduate: 9

Name

Year

Brian Guo

2015-

Program Graduate (PhD) Rotation student

Edwin Lee

2015-

Bachelors (Honors)

Munira Kachwala

2014 -

Project Mango and colon and health Novel targets in triple negative breast cancer Skeletal Dysplasia/drug discovery Interactions of natural products with P450 enzymes

Guanan Li

2014 -

Dede Ekoue

2014 -

Graduate (PhD) Graduate (PhD) (committee member) Graduate (PhD) Committee member

Anastasia Shiskoff

2014 -

PharmD

Skeletal Dysplasia/drug discovery

Yueting Wang

2013 -

UI CENTRE

UI CENTRE

Sakina Petiwala, MS, MS Joseph Sahagun Emma Bodell

2011 2014 2014 -

Bachelors (Honors) Bachelors (Honors) Bachelors (PrePharm)

Rosemary and Prostate Cancer Natural Products for Cancer Natural Products for Cancer Phytochemicals for hypercholesterolemia.

Visiting Scholar Post-doctoral fellowship

Xanthones for Colon Cancer α-mangostin for prostate cancer

Pharmacy Student

Xanthones for colon cancer Pharmacokinetics of natural products Mangosteen for prostate cancer Rosemary Extract for prostate cancer Rosemary Extract for prostate cancer Rosemary Extract for prostate cancer Mangosteen Extract for prostate cancer Xanthones for prostate cancer

Robin Varghese Miao (Mel) Yan, PhD Gongbo Li, PhD Emily R. Householter Atul Ramaiya, PhD

2013 2013 2014 2011 – 2014 2013 2011-12

Last known position PhD Student Undergraduate Honors PhD Student PhD Student (Medicinal Chemistry) PhD Student (Pathology) PharmD Student Pharmacokinetic Analysis Research Specialist (CCTS Certificate Program) Undergraduate Student Undergraduate Student Undergraduate Student Assistant Professor

Scientist

Stacey Thomas

2012

Bachelors (PrePharm)

Angela Puthenveetil

2012

Medical Student

Saba Berhe

2012

Masters (Pharm)

Ozair Rahman

2011

Medical Student

Dana Pierce

2011-12

Bachelors (Pre-Med)

John Rasmussen

2009-10

Pharmacy Student

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Post-Doctoral Fellow (Vanderbilt) Pharmacy Student Scientist at Hospira Pharmacy Technician Medical Student MS Pharmacy Student (University of Basel) Medical Student Undergrad Student Pharmacist

PI: Johnson, Jeremy

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Amanda Kohl

2009-10

Bachelors (Pre-Med)

Xanthones for prostate cancer

Harleen Handa

2008

Bachelors (Pre-Med)

Xanthones for prostate cancer

Chenelle Heren

2007

Bachelors (PrePharm)

Carnosol for prostate cancer

K-12 Teacher PharmD Student Chicago State University

GRANTS / FUNDING Current / Active / Funded American Cancer Society

(PI: Johnson, JJ)

07/01/2012 – 06/30/2016 $720,000 (Total) Title: Prostate Cancer Chemoprevention with Carnosol by Dual Disruption of AR/ER The goal of this research is to evaluate the dual disruption of AR and ERα with the natural product carnosol. Role: PI

National Institutes of Health (PI: Thatcher, G and Petukhov P) 09/22/2014 – 06/30/2016 UH2HL123610 (NHLBI) $1,663,662 (Y1 Total); $784,748 (Y1 UIC) Title: Therapeutic Targeting of Carotid Body Chemoreflex for Sleep Disordered Breathing Summary: In Aim 1 we will perform HTS 100,000 compounds to find inhibitors of CSE . Hits will then be further optimized based utilizing NMR and computer modeling approaches. Compound will then be examined for preliminary toxicity in MEF cell lines. One dose IP of 18 compounds (4 animals per) will then be examined. Role: Co-investigator

Hans W. Vahlteich Research Scholar Award (PI: Johnson) $50,000 Title: Optimizing Xanthones from Garcinia mangostana as Androgen Receptor Degradation Enhancers Summary: Gartanin and α-mangostin will be modified through medicinal chemistry strategies to achieve AR degradation properties with an EC50