Professor Christer Betsholtz, PhD

Curriculum Vitae Christer Betsholtz Professor Christer Betsholtz, PhD Born 11 July 1959 in Stockholm Sweden. Swedish Citizen. Research Area Vascular...
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Curriculum Vitae

Christer Betsholtz

Professor Christer Betsholtz, PhD Born 11 July 1959 in Stockholm Sweden. Swedish Citizen. Research Area Vascular biology, with a focus on cellular and molecular mechanisms for angiogenesis and vascular permeability. Education Bachelor of Medicine 1982; PhD 1986; Associate Professor (Docent title) 1987 Current appointments Professor of Tumor Biology (with tenure) at Uppsala University, 2011Professor of Vascular Biology (with tenure) at Karolinska Institutet, 2004Previous appointments Professor of Medical Biochemistry (with tenure) at Gothenburg University 1994-2004 Associate professor of Experimental Pathology, Uppsala University and the Swedish Cancer Foundation 1991-1993 Assistant professor of Experimental Pathology, Uppsala University, the Swedish Cancer Foundation, the Swedish Medical Research Council 1987-1990 Commissions of trust (selected) Member of the Nobel Assembly for Physiology or Medicine since 2006 Member of the Nobel Committee for Physiology or Medicine, 2007-2010 Member of the Swedish Royal Academy of Sciences, Class VII since 2007 Member of the Royal Society of Sciences at Uppsala since 2014 Member of European Molecular Biology Organization since 2004 Member of Academia Europaea since 2004 Member of the Scientific Board of the Swedish Cancer Foundation 2010-2012 Chairman of the Life Sciences Advisory Board at the Foundation for Strategic Research, Sweden, 1999-2002 Member of the SAB for the Verselius Research Center, VIB-KU-Leuven since 2013 (Chairman) Member of the SAB for the Max Planck Heart and Lung institute, Bad Nauheim since 2012 Member of the SAB for IFOM/EIO, the FIRC Cancer Center in Milan since 2003 (Chariman), Member of the SAB for the Structural Genomics Consortium, Stockholm Branch (2005-2010) Member of the SAB for the Center of Excellence in Developmental Biology Research Program, University of Helsinki, 2002-2006. Member of LS3 Panel for the evaluation of European Research Council starting grants since 2008, Chairman since 2010 Member of the EMBO panel for the selection of YIP members since 2013 Member of the Swedish Cancer Foundation grant evaluation panel PkB 2000-2009 (Chairman since 2006). Associate Editor, Arteriosclerosis, Thrombosis, and Vascular Biology, 2004-2008 Member of the Editorial Board, Developmental Cell since 2012 Honors & Awards (since 2000) 1989 1995 1997

Oscar Prize, Uppsala University. Fernström's Award for young investigators, Göteborg University Göran Gustavsson’s Prize in Molecular Biology

Curriculum Vitae 2002 2004 2008 2009 2009 2010 2010 2011 2011 2012 2014

Christer Betsholtz

Alkis Seraphim Lecture, Cambridge University (UK) Lundberg Medal, Lundberg Foundation (Swe) Russel Ross Endowed Lecture, Washington University (US) Söderberg Professor of Medicine, Royal Swedish Academy of Sciences 2009-2013 Distinguished Professor Award, Karolinska Institutet 2009-2013 Axel Hirsch’s Prize, Karolinska institutet The Del Monte Medal in Neuromedicine, Rochester University, NY (US) Laboratory ranked outstanding (the highest grade given only to the top 10%) following international evaluation of all research groups at Karolinska Institutet European Research Council Advanced Grant (2012-2017) Rockefeller University Nicholson Lecture (Oct 2012). Robert M Berne Memorial Lecturer at University of Virginia (invited for Nov 2014)

Scientific publications Author of 179 original articles, 36 review articles and 34 book chapters; see separate bibliography. Web of Science lists 347 publications [Betsholtz c OR Betscholtz c OR Besholtz C], 23729 citations (22675 without self citation) h-index 82 (Aug 4 2014). Google Scholar lists 326 publications cited 30406 times, h-index 87 [Christer Betsholtz]. PubMed lists 212 articles [Betsholtz C].

Research group structure The group comprises, in addition to Christer Betsholtz, 2 senior researchers, 2 research assistant professors, 8 post-doctoral fellows, 2 PhD students and 3 technicians. Supervision (alumni) Main supervisor for 22 alumni PhD students who completed their PhD at Uppsala University, Gothenburg University or Karolinska Institutet. Main supervisor for 15 alumni post-doctoral fellows. Current main project grants

Duration

European Research Council Advanced Grant (total award € 2.5 Mill) 2012-2017 Wallenberg Scholar from the Wallenberg Foundation 3 MSEK/yr 2013-2017 Swedish Research Council Project grant 1.3 MSEK/year 2013-2017 Swedish Cancer Foundation 2.0 MSEK/year 2012-2014 Knut and Alice Wallenberg Foundation (shared, total award 35 MSEK) 2010-2014 Karolinska Institute Distinguished Professor Award 0.7MSEK/year 2011-2015 International activities Invited speaker at > 150 international meetings in the fields of Vascular Biology, Cell Biology, Cancer Research, Kidney Research and Diabetes Research during 1990-2013. Numerous keynote lectures, including Angiogenesis Gordon Research Conference 2007 and the International Vascular Biology Meeting (IVBM) 2008. Invited lectures at IVBM 2012 and 2014. Organizer of scientific symposia: Annual European School of Hematology meetings in Angiogenesis 2002-2007 (Chair 2006). Kloster Seeon Angiogenesis Meeting (Chair) 2008. Novartis Foundation Symposium on Vascular Development 2006 (Chair). Entrepreneurial achievements: Co-founder of AngioGenetics AB 2001 (closed 2010). Co-founder of Cellartis AB, 2001 (acquired by Cellectis (Fr) 2011)

Curriculum Vitae

Christer Betsholtz

1. Original publications (10 most important marked **) 1

Andersson, T., Betsholtz, C. and Hellman, B. Calcium and pancreatic ß-cell function. 12. Modification of 45Ca fluxes by excess of K+. Acta Endocrinologica 96,87-92 (1981)

2

Andersson, T., Betsholtz, C. and Hellman, B. Granular calcium exchange in glucose-stimulated pancreatic ß-cells. Biomed Res 3,29-36 (1982)

3

Betsholtz, C., Heldin, C.-H., Nistér, M., Ek, B., Wasteson, Å. and Westermark, B. Synthesis of a PDGF-lika growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus. Biochem Biophys Res Commun 117,176-182 (1983)

4

Betsholtz, C. and Westermark, B. Growth factor-induced proliferation of human fibroblasts in serum-free culture depends on cell density and extracellular calcium concentration. J Cell Physiol 118,203-210 (1984)

5

Betsholtz, C., Westermark, B., Ek, B and Heldin, C.-H. Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation Cell 39,447-457 (1984)

6

Johnsson, A., Betsholtz, C., von der Helm, K., Heldin, C.-H. and Westermark, B. Plateletderived growth factor agonist activity of a secreted form of the v-sis oncogene product. Proc Natl Acad Sci USA 82,1721-1725 (1985)

7

Goustin, A.S., Betsholtz, C., Pfeifer-Ohlsson, S., Persson, H., Rydnert, J., Bywater, M., Holmgren, G., Heldin, C.-H., Westermark, B. and Ohlsson, R. Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell 41,301-312 (1985)

8

Nygren P., Andersson, T. and Betsholtz, C. Effects of metabolic inhibitors on the distribution of 45-Ca in subcellular fractions from pancreatic islets. Biochemistry International 10,881-888 (1985)

9

Pfeifer-Ohlsson, S., Rydnert, J., Goustin, A.S., Larsson, E., Betsholtz, C. and Ohlsson, R. Celltype-specific pattern of myc proto-oncogene expression in developing human embryos. Proc Natl Acad. Sci USA 82,5050-5054 (1985)

10

Betsholtz, C., Bywater, M., Westermark B., Bürk, R. and Heldin, C.-H. Expression of the c-sis gene and secretion of a platelet-derived growth factor-like molecule by simian virus 40transformed BHK cells Biochem Biophys Res Commun 130, 753-760 (1985)

11

Johnsson, A., Betsholtz, C., Heldin, C.-H. and Westermark, B. Antibodies against plateletderived growth factor inhibit acute transformation by simian sarcoma virus. Nature 317,438440 (1985)

12

Knott, T.J., Rall, S.C., Innerarity, T.L., Jacobson, S.F., Urdea, M.S., Levy-Wilson, B., Powell, L., Pease, R., Eddy, R., Nakai, H., Byers, M., Priestley, L., Robertson, E., Rall, L.B., Betsholtz, C., Shows, T.B., Mahley, R.W. and Scott, J. Human apolipoprotein B: Structure of carboxyterminal domains, sites of gene expression and chromosomal localization. Science 220,37-43 (1985)

13

Heldin, C.-H., Johnsson, A., Wennergren, S., Wernstedt, C., Betsholtz, C. and Westermark, B. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of

Curriculum Vitae

Christer Betsholtz

PDGF A chains. Nature 319,511-514 (1986) **14 Betsholtz, C., Johnsson, A., Heldin, C.-H., Westermark, B., Lind, P., Urdea, M.S., Shows, T.B., Philpott, K., Mellor, A., Knott, T.J. and Scott, J. Complementary DNA sequence and chromosomal localisation of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320,695-699 (1986) 15

Johnsson, A., Betsholtz, C., Heldin, C.-H. and Westermark, B. The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation. EMBO J 5,1535-1541 (1986)

16

Paulsson, Y., Bywater, M., Pfeifer-Ohlsson, S., Ohlsson, R., Heldin, C.-H., Westermark, B. and Betsholtz, C. Growth factors induce early pre-replicative changes in senescent human fibroblasts. EMBO J 5,2157-2162 (1986)

17

Betsholtz, C., Johnsson, A., Heldin, C.-H. and Westermark, B. Efficient reversion of simian sarcoma virus- transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc Natl Acad Sci USA 83,6440-6444 (1986)

18

Sejersen T., Betsholtz, C., Sjölund, M., Heldin, C.-H., Westermark, B. and Thyberg, J. Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A-chain but not the B-chain (c-sis ) of platelet- derived growth factor (PDGF) and produce a PDGF-like protein. Proc Natl Acad Sci USA 83,6844-6848 (1986)

19

Westermark, B., Johnsson, A., Paulsson, Y., Betsholtz, C., Heldin, C.-H., Herlyn, M., Rodeck, U. and Koprowski, H. Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Proc Natl Acad Sci USA 83, 7197-7200 (1986)

20

Betsholtz, C., Bergh, J., Bywater, M., Pettersson, M., Johnsson, A., Heldin, C.-H., Ohlsson, R., Knott, T.J., Scott, J., Bell, G.I. and Westermark, B. Expression of multiple growth factors in a human lung cancer cell line. Int J Cancer 39,502-507 (1987)

21

Collins, T., Pober, J.S., Gimbrone Jr, M.A., Hammacher, A., Betsholtz, C., Westermark, B. and Heldin, C.-H. Cultured human endothelial cells express platelet-derived growth factor A-chain. Am J Pathol 127,7-12 (1987)

22

Alitalo, R., Andersson, L.C., Betsholtz, C., Nilsson, K., Westermark, B., Heldin, C.-H. and Alitalo, K. Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines. EMBO J 6,1213-1218 (1987)

23

Peres, R., Betsholtz, C., Westermark, B. and Heldin, C.-H. Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. Cancer Res 47,34253429 (1987)

24

Nistér, M., Wedell, B., Betsholtz, C., Bywater, M., Pettersson, M., Westermark B. and Mark, J. Evidence for progressional changes in the human malignant glioma line U-343 MGa: Analysis of karyotype and expression of genes encoding the subunit chains of platelet-derived growth factor. Cancer Res. 47,4953-4961 (1987)

25

Grofova, M., Bywater, M., Betsholtz, C., Bizik, J., Lizonova, A., Matoskova, B. and Westermark, B. A non- tumorigenic human cell line B-5GT derived from a cell tumor of bone produces a growth factor and expresses two oncogenes. The Cancer Journal 1,307-313 (1987)

26

Rorsman, F., Bywater, M., Knott, T.J., Scott, J. and Betsholtz, C. Structural characterization of

Curriculum Vitae

Christer Betsholtz

the platelet- derived growth factor A-chain cDNA and gene: Alternative exon usage predicts two different precursor proteins. Mol Cell Biol 8,571-577 (1988) 27

Söderdahl, G., Betsholtz, C., Johansson, A., Nilsson, K. and Bergh, J. Differential expression of platelet- derived growth factor and transforming growth factor genes in small- and non-small cell human lung cancer cell lines. Int J Cancer 41,636-641 (1988)

28

Bywater, M., Rorsman, F., Bongcam-Rudloff, E., Mark, G., Heldin, C.-H., Westermark, B. and Betsholtz, C. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in Rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects. Mol Cell Biol 8,2753-2762. (1988)

29

Fukushima, Y., Byers, M., Betsholtz, C., Knott, T., Scott, J., Watkins, P., Tryggvason, K., Shows, T.B. Mapping PDGFA, EPO, and LAMB1 to specific sites on chromosome 7q. Cytogenet. Cell Genet. 46, 616, (1987)

30

Nistér, M., Libermann, T.A., Betsholtz, C., Pettersson, M., Claesson-Welsh, L., Heldin, C.-H., Schlessinger, J. and Westermark, B. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-a and their receptors in human glioma cell lines. Cancer Res 48,3910-3918 (1988)

31

Claesson-Welsh, L., Eriksson, A., Morén, A., Severinsson, L., Ek, B., Östman, A., Betsholtz, C. and Heldin, C.- H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B- chain-containing PDGF molecules. Mol Cell Biol 8,3476-3486 (1988)

32

Beckmann, M.P., Betsholtz, C., Heldin, C.-H., Westermark, B., Di Marco E., Di Fiore, P.P. Robbins, K.C., and Aaronson, S.A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF- B chains. Science 241,1346-1349 (1988)

33

Stenman, G., Rorsman, F. and Betsholtz, C. Sublocalization of the PDGF A-chain gene to human chromosome 7, band q11.23 by in situ hybridization. Exp Cell Res 178,180-184 (1988)

34

Östman, A., Rall, L., Hammacher, A., Wormsted, M.A., Coit, D., Valenzuela, P., Betsholtz, C., Westermark, B., and Heldin, C.-H. Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer. J Biol Chem 263,16202-16208 (1988)

35

Hermansson, M., Nistér, M., Betsholtz, C., Heldin, C.-H., Westermark, B. and Funa, K. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad. Sci USA 85,7748-7752 (1988)

36

Ashcroft, F.M., Ashcroft, S.J.H., Berggren, P.-O., Betsholtz, C., Rorsman, P., Trube, G. and Welsh, M. Expression of K-channels in Xenopus laevis oocytes injected with poly(A+) RNA from the insulin-secreting ß- cell line HIT T15. FEBS Lett 239,185-189 (1988)

37

Matoskova, B., Rorsman, F., Svensson, V. and Betsholtz, C. Alternative splicing of the plateletderived growth factor A chain transcript: Occurrence in normal as well as transformed cells and in several mammalian species. Mol Cell Biol 9,3148-3150 (1989)

38

Betsholtz, C., Christmanson, L., Engström, U., Rorsman, F., Svensson, V., Johnson, K.H. and Westermark, P. Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett 251,261-264 (1989)

39

Östman, A., Bäckström, G., Fong, N., Betsholtz, C., Wernstedt, C., Hellman, U., Westermark,

Curriculum Vitae

Christer Betsholtz

B., Valenzuela, P. and Heldin, C.-H. Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cervisiae. Evidence for differences in receptor binding and functional activities. Growth factors 1,271-281 (1989) 40

Betsholtz, C., Svensson, V., Rorsman, F., Engström, U., Westermark, G.T., Wilander, E., Johnson, K.H. and Westermark, P. Islet amyloid polypeptide: cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus. Exp Cell Res 183,484-493 (1989)

41

Westermark, P., Engström, U., Westermark, G.T., Johnson, K.H., Permerth, J. and Betsholtz, C. Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans. Diabetes Res Clin Pract 7,219-226 (1989)

42

Betsholtz, C., Christmansson, L., Engström, U., Rorsman, F., Jordan, K., O'Brien, T., Murtaugh, M., Johnson, K.H. and Westermark, P. The structure of cat islet amyloid polypeptide (IAPP) and identification of amino acid residues of potential significance for islet amyloid formation. Diabetes 39,118-122 (1990)

43

Johnson, K.H., O'Brien, T.D., Jordan, K., Betsholtz, C. and Westermark, P. The putative hormone islet amyloid polypeptide (IAPP) induces impaired glucose tolerance in cats. Biochem Biophys Res Commun 167, 507- 513 (1990)

44

Betsholtz, C., Baumann, A., Ashcroft, F.M., Ashcroft, S.J.H., Berggren, P.-O., Pongs, O., Rorsman, P., Sandblom, J., and Welsh, M. Expression of voltage-gated channels in insulinproducing cells: Analysis by polymerase chain reaction. FEBS Lett 263, 121-126 (1990)

45

Westermark, P., Engström, U., Westermark, G.T., Johnson, K.H. and Betsholtz, C. Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87,5036-5040 (1990)

46

Christmanson, L., Rorsman, F., Stenman, G.,Westermark, P. and Betsholtz, C. The human islet amyloid polypeptide gene: Organization, chromosomal localization and identification of a promoter region. FEBS Lett.267,160-166 (1990)

47

Jordan, K., Murtaugh, M.P., O'Brien, T.D., Westermark, P., Betsholtz, C. and Johnson, K.H. cDNA predicted sequence of canine IAPP provides important clues regarding pathogenesis and amyloidogenesis in type 2 diabetes. Biochem Biophys Res Commun 169,502-508. (1990)

48

Welsh, M., Claesson-Welsh, L., Hallberg, A., Welsh, N., Betsholtz, C., Arkhammar, P., Nilsson, T. Heldin, C.- H. and Berggren, P.-O. Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF β receptor in isolated pancreatic islet cells stimulates DNA synthesis. Proc Natl Acad Sci USA 87,5807-5811 (1990)

49

Leveen, P., Claesson, Welsh, L., Heldin, C.-H., Westermark, B. and Betsholtz, C. Expression of the genes for PDGFs and its receptors in human sarcoma cell lines. Int J Cancer 46,1066-1070 (1990)

50

Madsen, O., Nielsen, J.H., Michelsen, B., Westermark, P., Betsholtz, C., Nishi, M. and Steiner, D.F. Islet amyloid polypeptide (IAPP/Amylin) and insulin expression are controlled differently in primary and transformed islet cells. Mol Endo 5,143-148 (1991)

51

Östman, A., Andersson, M., Betsholtz, C., Westermark, B. and Heldin, C.-H. Identification of a cell retention signal in the B-chain of PDGF and in the long splice version of the A-chain. Cell Regul. 2,503-512 (1991)

Curriculum Vitae

Christer Betsholtz

52

Bongcam-Rudloff, E., Nistér, M., Stenman, G., Huebner, K., Croce, C.M., Betsholtz, C. and Westermark, B. Human glial fibrillary acidic protein: Complementary DNA cloning, chromosomal localization and messenger RNA expression in human glioma cell lines of various phenotypes. Cancer Res 51,1553-1560 (1991)

53

Christmanson, L., Betsholtz, C., Johansson, B. and Westermark, P. The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis. FEBS Lett 281,177180 (1991)

54

Zierath, J.R., Galuska, D., Engström, Å., Johnson, K.H., Betsholtz, C., Westermark, P. and Wallberg- Henriksson, H. Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester- stimulated glucose-transport in in vitro incubated human muscle strips. Diabetologia 35,26-31 (1992)

55

Rorsman, F. and Betsholtz, C. Characterization of the mouse PDGF A chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing. Growth Factors 6,303-313 (1992)

56

Stenman, G., Rorsman, F., Huebner, K. and Betsholtz, C. The human platelet-derived growth factor A chain gene (PDGFA) maps to chromosome 7p22. Cytogenet. Cell. Genet. 60,206-207 (1992)

57

Rorsman, F. Levéen, P. and Betsholtz, C. Platelet-derived growth factor (PDGF) A-chain heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites. Growth Factors 7,241- 251 (1992)

58

Leveen, P., Betsholtz, C. and Westermark, B. Evidence for negative transacting mechanisms controlling expression of platelet-derived growth factor A-chain and B-chain mRNA in somatic cell hybrids. Experimental Cell Res. 207,283-289 (1993)

59

Örtoft, E., Påhlman, S., Andersson, G., Parrow, V., Betsholtz, C. and Hammerling, U. Human GAP-43 gene expression: Multiple start sites for initiation of transcription in differentiating neuroblastoma cells. Mol. Cell. Neurosci. 4: 549-561 (1993)

60

Christmanson, L., Betsholtz, C., Leckström, A., Engström, U., Cortie, C., Johnson, K.H. and Westermark, P. Islet amyloid polypeptide in the rabbit and European hare: Relationship with islet amyloidogenesis. Diabetologia 36, 183-188 (1993)

61

Van der Meeren, A., Seddon, M.B., Betsholtz, C., Lechner, J.F. and Gerwin, B. Tumorigenic conversion of human mesothelial cells is a consequence of platelet-derived growth factor-A chain overexpression. Am. J. Respir. Cell Mol. Biol. 8,214-221 (1993)

62

Westermark G.T., Christmanson, L., Terenghi, G., Permerth, J., Betsholtz, C., Larsson, J., Polak, J.M. and Westermark, P. Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization and evidence of altered secretion in conjunction with islet amyloid. Diabetologia, 36,323-328 (1993)

63

Velloso, L., Kämpe, O., Hallberg, A., Christmanson, L., Betsholtz, C., Karlsson, F.A. Determination of autoantibodies against glutamate decarboxylase in insulin-dependent diabetes mellitus using a radioligand produced by eukaryotic expression. J. Clin. Invest. 91,2084-2090 (1993)

64

Christmanson, L., Westermark, P. and Betsholtz. C. Islet amyloid polypeptide (IAPP/amylin) stimulates cyclic AMP accumulation via the calcitonin receptor. Biochem. Biophys. Res. Commun. 205,1226-1235 (1994)

Curriculum Vitae

Christer Betsholtz

**65 Levéen, P., Pekny, P., Gebre-Medhin, S., Swolin, B., Larsson, E. and Betsholtz, C. Mice deficient for PDGF B show renal, cardiovascular and hematological abnormalities. Genes Dev 8, 1875-1887 (1994) 66

Kulkarni, P.S., Sundqvist, K., Betsholtz, C., Höglund, P., Wiman, K., Zhivotovsky, B. Bertolero, F., Liu, Y. and Grafström, R. Characteriszation of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene. Carcinogenesis 16, 2515-2521 (1995)

67

Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Westermark, B. and Betsholtz, C. Mice lacking glial fibrillary acidic protein (GFAP) develop and reproduce normally. EMBO J 14, 1590-.1598 (1995)

68

Pekny, M., Östman, A., Pekna, M., Törnell, J., Fenstein, R., Heldin, C.-H., Westermark, B. and Betsholtz, C. Luteal failure in transgenic mice carrying a PDGF dominant-negative mutant/GH hybrid transgene. Transgenics 1, 515-523 (1995)

**69 Boström, H., Willetts, K., Pekny, M., Levéen, P., Hedstrand, H., Pekna, M., Schalling, M., Nilsson, M., Gebre- Medhin, S., Kurland, S., Törnell, J., Heath, J.K and Betsholtz, C. PDGF-A signaling is a critical event in lung alveolar myofibroblast ontogeny and alveogenesis. Cell 85, 863-873 (1996) 70

Arkblad, E.L., Betsholtz, C., and Rydström, J. The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse. Biochim. Biophys. Acta 1273,203-205 (1996)

71

Tatzelt, J., Maeda, N., Pekny, M., Yang, S.-L., Betsholtz, C., Eliasson, C., Cayetano, J., Camerino, A.P., DeArmond, S.J. and Prusiner, S. Scrapie in mice deficient for either apolipoprotein E or glial fibrillary acidic protein. Neurology. 47, 449-453 (1996)

**72 Lindahl, P., Johansson, B., Levéen, P., and Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B deficient mice. Science, 277, 242-245 (1997) 73

Lindahl, P., Karlsson, L., Hellström, M., Gebre-Medhin, S., Willetts, K., Heath, J.K. and Betsholtz, C. Alveogenesis failure in PDGF-A deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development, 124,3943-3953 (1997)

74

Pekna, M., Hietala, M.A., Rosklint, T., Betsholtz, C. and Pekny, M. Targeted disruption of the murine gene coding for the third complement component (C3). Scand. J. Immunol. 47:25-29 (1998)

75

Pekny, M., Stanness, K.A., Eliasson, C., Betsholtz, C. and Janigro, D. Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice. Glia 22:390-400 (1998)

76

Pekna, M., Hietala, M.A., Landin, A., Betsholtz, C and Pekny, M. Mice deficient for the complement factor B develop and reproduce normally. Scand J Immunol. 47:375-380 (1998)

77

Pekny, M., Eliasson, C., Chien, C.-L-. Kindblom, L.G., Liem, R., Hamberger, A. and Betsholtz, C. GFAP- deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit reduced amount of intermediate filaments and increased cell saturation density. Exp. Cell Res. 239:332-343 (1998)

78

Calver, A.R., Hall, A.C., Yu, W.-P., Walsh, F.S., Heath, J.K., Betsholtz, C., and Richardson,

Curriculum Vitae

Christer Betsholtz

W.D. Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 20:869882(1998) 79

Lindahl, P., Hellström, M., Kalén, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P. and Betsholtz, C. Paracrine PDGF-B/PDGF-Rβ signalling controls mesangial cell development in kidney glomeruli. Development 125:3313-3322 (1998)

80

Gebre-Medhin, S., Mulder, H., Pekny, M., Westermark, G.T., Törnell, J. Westermark, P., Sundler. F., Ahrén, B., and Betsholtz, C. Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem. Biophys. Res. Commun. 250:271277 (1998)

81

Gebre-Medhin, S., Mulder, H., Zhang, Y., Sundler, F. and Betsholtz, C. Reduced nociceptive behaviour in islet amyloid polypeptide (amylin) knockout mice. Mol Brain Res, 63:180-183 (1998)

82

Ding, M., Eliasson, C., Betsholtz, C., Hamberger, A. and Pekny, M. Altered taurine release following hypotonic stress in astrocytes fropm mice deficient for GFAP and vimentin. Mol. Brain Res. 62:77-81(1998)

83

Wang, S., Gebre-Medhin, S., Betsholtz, C., Ståhlberg, P., Zhou, Y., Larsson, C., Weber, G., Feinstein, R., Öberg, K., Gobl, A. and Skogseid, B. Targeted disruption of mouse PLC-β3 gene results in early embryonic lethality. FEBS Lett. 441:261-265 (1998)

84

Fruttiger, M., Karlsson, L., Hall, A., Abramsson, A., Calver, A.R., Boström, H., Willetts, K., Berthold, C.-H., Heath, J.K., Betsholtz, C. and Richardson, W.R. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 126:457467(1999)

85

Karlsson, L., Bondjers, C. and Betsholtz, C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126:2611-2621 (1999)

86

Pekny, M., Johansson, C.B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H. and Frisén, J. Abnormal rection to central nervous system injury in mice lacking glial fibrillary protein and vimentin. J. Cell Biol. 145:503-514 (1999)

87

Ohlsson, R., Falk, P., Hellström, M., Lindahl, P.,Boström, H., Franklin, G., Ährlund-Richter, L., Pollard, J., Soriano, P., and Betsholtz, C. PDGF-B regulates the formation of the labyrinthine layer of the mouse fetal placenta. Dev Biol. 212:124-136 (1999)

88

Eliasson, C., Sahlgren, C., Berthold, C.-H., Betsholtz, C., Eriksson, J.E., and Pekny, M. Intermediate filament partnerships in astrocytes. J. Biol. Chem. 274:23996-24006 (1999)

**89 Hellström, M., Kalén, M., Lindahl, P., Abramsson, A. and Betsholtz, C. Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126:3047-3055 (1999) 90

Scita, G., Nordström, J., Tenca, P., Carbone, R., Giardina, G., Panunzio, M., Gutkind, S., Bjarnegård, M., Betsholtz, C. and DiFiore, P.P. Eps8 and E3B1 transduce signals from ras to rac. Nature 401:290-293 (1999)

91

Johansen, F.-E., Pekna, M., Natvig Norderhaug, I., Haneberg, B., Hietala, M.A., Krajci, P., Betsholtz, C., and Brandtzaeg, P. Absence of epithelial IgA transport, with increased mucosal leakiness, in pIgR/SC-deficient mice. J. Exp. Med. 190,915-922 (1999)

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Christer Betsholtz

92

Mulder, H., Gebre-Medhin, S., Betsholtz, C., Sundler, F. and Ahrén, B. Islet amyloid polypeptide (amylin)- deficient mice develop a more severe form of alloxan-induced diabetes. Am. J. Physiol. 278: E684-691 (2000)

93

Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Bäckström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C.-H., Alitalo, K., Östman, A., and Eriksson U. PDGF-C is a novel protease-activated ligand for the PDGF α receptor. Nature Cell Biology. 2:302-309 (2000)

94

Gnessi, L., Basciani, S., Mariani, S., Arizzi, M., Spera, G., Wang, C., Bondjers, C., Karlsson, L. and Betsholtz, C. Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A deficient mice. J. Cell. Biol. 149:1019-1026 (2000)

95

Karlsson, L., Lindahl, P., Heath, J.K. and Betsholtz, C. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis Development 127:3457-3466 (2000)

96

Kaminski, W., Lindahl, P., Lin, N.L., Broudy, V.C., Crosby, J.R. Swolin, B., Bowen-Pope, D.F., Martin, P., Ross, R., Betsholtz, C., and Raines, E. Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood 97:19901998 (2001)

97

Aase, K., von Euler, G., Li, X., Pontén, A., Thorén, P., Cao, Y., Gebre-Medhin, S., Pekny, M., Betsholtz, C. and Eriksson, U. Vacsular endothelial growth factor-B deficient mice display an atrial conduction defect. Circulation 104:358-364 (2001)

**98 Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H. and Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis J. Cell Biol. 153:543-553 (2001) 99

Arkblad, E., Betsholtz, C., Mandoli, D. And Rydström, J. Characterization of a nicotinamide nucleotide transhydrogenase gene from the green algae Acetabularia acetabulum and comparison of its structure with those of the corresponding genes in mouse and Caenorhabditis elegans. Biochim. Biophys. Acta 1520:115- 123 (2001)

100

Johansson, B., Halldner, L., Dunwiddie, T.W., Masino, S., Poelchen, W., Giménez-Llort, L., Escorihuela, R.M., Fernández-Teruel, A., Wiesenfeld-Hallin, Z. Xu, X.J., Herlenius, E., Hårdemark., A., Betsholtz, C. and Fredholm, B.B. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc. Natl. Acad. Sci USA 98:94079412 (2001)

101

Buetow, B.S., Crosby, J.R., Kaminski, W.E., Ramachandran, R.K., Lindahl, P,, Martin, P., Betsholtz, C., Seifert, R.A., Raines, E.W., Bowen-Pope, D.F. Platelet-derived growth factor Bchain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization. Am. J. Pathol. 159:1869-1976 (2001)

102

Aase, K., Abramsson, A., Karlsson, L., Li, X., Fredriksson, L., Betsholtz C., and Eriksson, U. Expression of PDGF-C in adult and developing mouse tissues. Mech Dev. 110:187-191 (2002)

103

Boström, H., Gritli-Linde, A. and Betsholtz, C. PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not early lung branching morphogenesis. Dev. Dyn. 223:155-162 (2002)

104

Abramsson, A., Berlin, Ö., Papayan, H., Paulin, D., Shani, M., and Betsholtz, C. Analysis of

Curriculum Vitae

Christer Betsholtz

mural cell recruitment to tumor vessels. Circulation 105:112-117 (2002) 105

Takemoto, M., Asker, N., Gerhardt, H., Lundkvist, A., Johansson, B.R., Saito, Y. and Betsholtz, C. A new method for large scale isolation of kidney glomeruli from mice. Am. J. Pathol. 161:799-805 (2002)

106

Enge, M., Bjarnegård, M., Gerhardt, H., Gustafsson, E., Kalén, M., Asker, N., Hammes, H.-P., Shani, M., Fässler, R. and Betsholtz, C. Endothelium-specific PDGF-B ablation mimics diabetic retinopathy. EMBO J. 21:4307-4316 (2002)

107

Prakash, N., Hansson, E., Betsholtz, C., Mitsiadis, T., and Lendahl, U. Mouse notch 3 expression in pre- and postnatal brain: relationship to the stroke and demential syndrome CADASIL. Exp Cell Res. 278:31-44 (2002)

108

Kozaki, K., Kaminski, W.E., Tang, J., Hollenbach, S., Lindahl, P., Sullivan, C., Yu, J.C., Abe, K., Martin, P.J., Ross, R., Betsholtz, C., Giese, N.A. and Raines, E.W. Blockade of plateletderived growth factor or its receptors transiently delays but not prevent fibrous cap formation in ApoE null mice. Am. J. Pathol. 161:1395- 1407 (2002)

109

Hammes, H.-P., Lin, J., Renner, O., Shani, M., Lundqvist, A., Betsholtz, C., Brownlee, M., and Deutsch, U. Pericytes and the pathogenesis of diabetic retinopathy. Diabetes 51:3107-3112 (2002)

110

Ruhrberg, C., Gerhardt, H., Watson, R., Golding, M., Ioannidou, S., Betsholtz, C. and Shima, D.T. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 16:2684-2698 (2002)

111

Enge, M., Wilhelmsson, U., Abramsson, A., Edsbagge, J., Kühn, R., Betsholtz, C., Pekny, M. Neuron-specific ablation of PDGF-B is compatible with normal CNS development and astroglial response to injury. Neurochem. Res. 28,271-179 (2003)

112

Cho, H., Kozasa, T., Bondjers, C., Betsholtz, C. And Kehrl, J.H. Pericyte specific expression of RGS5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J. 17,(3):440-442 (2003); fulltext at FASEB J. (January 2, 2003) 10.1096/fj.02-0340fje

113

Bondjers, C., Hellström, M., Asker, N., Kalén, M., Scheidl, S., Abramsson, A., Renner, O., Lindahl, P., Cho, H., Kehrl, J.H., Betsholtz, C. Transcript profiling of PDGF-B deficient embryos identifies RGS5 as a novel marker for developing pericytes and vascular smooth muscle cells. Am J Pathol. 162,721-729 (2003)

114

Tocchetti, A., Scita, G., Di Fiore, P.P. and Betsholtz, C. In silico analysis of the EPS8 gene family: genomic organization, expression profile and protein structure. Genomics 81,234-244 (2003)

**115 Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. and Betsholtz, C. VEGF guides angiogenic sprouting utilizing endothelial tip-cell filopodia. J Cell Biol 161:1163-1177 (2003) 116

Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellström, M., Bäckström, G., Fredriksson, S., Landegren, U., Nyström, H., Bergström, G., Dejana, E., Östman, A., Lindahl, P. and Betsholtz, C. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev, 17:1835-1840 (2003)

117

Haigh, J.J., Morelli, P., Gerhardt, H., Haigh, K., Tsuen, J., Damert, A., Miquerol, L., Muhlner, U., Klein, R., Ferrara, N., Wagner, E.F., Betsholtz, C., Nagy, A. Cortical and retinal defects

Curriculum Vitae

Christer Betsholtz

caused by disage dependent reductions in VEGF-A paracrine signaling. Dev Biol 262:225-241 (2003) 118

Abramsson, A., Lindblom, P., Betsholtz, C. Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 112: 1142-1151 (2003)

119

Basciani, S., Mariani, S., Arizzi, M., Ricci, G., Galdieri, M., Spera, G., Bondjers, C., Betsholtz, C., Gnessi, L. Expression of PDGF-A and B-chain and of PDGF receptor a- and b-subunits in the epididymis. Failure of epididymal development in PDGF-A-deficient mice. Biol Reprod 70:168-177 (2004)

120

Karkkainen, M.J., Haiko, P., Partanen, J., Taipale, J., Janne, M., Rauvala, H., Betsholtz, C., Alitalo, K. Critical Role of VEGF-C in embryonic and postnatal lymphangiogenesis. Nature Immunology 5:74-80 (2004)

121

Furuhashi, M., Sjöblom, T., Abramsson, A., Ellingsen, J., Micke, P., Bergsten-Folestad, E., Eriksson, U., Heuchel, R., Betsholtz, C., Heldin, C,-H., Östman, A. PDGF production by B16 melanoma cells leads to increased pericyte coverage of vessels and an associated increase in tumor growth rate. Cancer Res 64:2725-2733 (2004)

122

Bjarnegård, M., Enge, M., Norlin, J., Gustafsdottir, S., Fredriksson, S., Abramsson, A., Takemoto, M., Gustafsson, E., Fässler, R. and Betsholtz, C. Endothelium-specific ablation of PDGF-B leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development 131:1847-1857 (2004)

123

Popova, S., Rodriguez-Sánchez, B., Lidén, Å., Betsholtz, C., van den Bos, T. and Gullberg, D. The mesenchymal a11b1 integrin attenuates PDGF-BB stimulated chemotaxis of embryonic fibroblasts on collagen. Dev Biol 270:427-442 (2004)

124

Lundkvist, A., Reichenbach, A., Betsholtz, C., Carmeliet, P., Wolburg, H., and Pekny, M. Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. J Cell Sci 117:3481-3488 (2004)

125

Gerhardt, H., Ruhrberg, C., Abramsson, A., Fujisawa, H., Shima, D., and Betsholtz, C. Neuropilin-1 is dispensable during angiogenic sprouting but required for vascular fusion in the developing CNS. Dev Dyn 231:503-509 (2004)

126

Gullberg, M., Gustafsdottir, S., Schallmeiner, E., Jarvius, J., Bjarnegård, M., Betsholtz, C., Landegren, U., Fredriksson, S. Cytokine detection by antibody-based proximity ligation. Proc Natl Acad Sci USA 101:8420- 8424 (2004)

127

Ding, H., Wu, X., Boström, H., Kim, I., Koh, G.Y. Wong, N., Tsoi, B., OʼRourke, M., Soriano, P., Betsholtz, C., Hart, T.C., Marazita, M.L., Field, L.L., Tam, P.P.L. and Nagy, A. A specific requirement of PDGF-C in palate formation and PDGFR-a signaling. Nature Genetics 36:11111116 (2004)

128

Renner, O., Romero, L., Carnero, A., Betsholtz, C., Euler, A. Identification of transcripts specific for physiological gene activation by platelet-derived growth factor (PDGF) B in intact brain tissue. J Cell Biochem 95:859-867 (2005)

129

Tang, J., Kozaki, K., Farr, A.G., Matrin, P.J., Lindahl, P., Betsholtz, C., Raines, E.W. The absence of platelet- derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis- prone ApoE-/- mice. Am J Pathol 167:901-912 (2005)

Curriculum Vitae

Christer Betsholtz

130

Xian, X., Håkansson, J., Stahlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H., and Semb, H. Pericytes limit tumor cell metastasis. J Clin Invest 116,642-651 (2006)

131

Takemoto, M., He, L., Norlin, J., Asp, J., Patrakka, J., Xiao, Z., Bondjers, C., Mostad, P., Samuelsson, T., Tryggvason, K. and Betsholtz C. Identification of novel kidney glomerulusspecific genes by large scale EST sequencing and microarray analysis. EMBO J, 25, 1160-1174 (2006)

132

Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P. Betsholtz, C. Microarray analysis of blood microvessels from PDGF-B and PDGFRb mutant mice identifies novel markers for brain pericytes. FASEB J, 20,1703-1705, (2006)

133

Rolny, C., Nilsson, I., Magnusson, P., Wennström, S., Karlsson, L., Lindblom, P., Betsholtz, C., Claesson- Welsh, L. Platelet-derived growth factor-BB induces migration and differentiation of endothelial cells in capillary sprouting during embryonal development. Blood, 108,1877-1886 (2006).

134

Nyström, H.C., Lindblom, P., Wickman, A., Andersson, I., Norlin, J., Fäldt, J., Lindahl., P., Skott, O., Bjarnegård, M., Fitzgerald, S., Caidahl., K., Gan, L., Betsholtz, C. And Bergström, G. Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries. Cardiovasc Res 71,557-565 (2006)

135

Offenhäuser, N., Castelletti, D., Mapelli, L., Soppo, B.E., Regondi, M.C., Rossi, P., DʼAngelo, E., Frassoni, C., Amadeo, A., Tocchetti, A., Pozzi, B., Disanza, A., Guarnieri, D., Betsholtz, C., Scita, G., Heberlein, U., Di Fiore, P.P. Increased ethanol resistance and consumption in eps8 knockout mice correlates with altered actin dynamics. Cell, 127,213-226 (2006)

136

Abramsson, A., Kurup, S., Yamada, S., Lindblom, P., Ledin, J., Ringwall, M., Kjellén, L., Bondjers, G., Li, J-P., Lindahl, U., Spillmann, D., Betsholtz, C., Gerhardt, C. Defective Nsulphatation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev, 21,316- 331 (2007)

137

Patrakka, J., Xiao, Z., Nukui, M., Takemoto, M., He, L., Oddsson, A., Perisic, L., Uhlén, M., Jalanko, H., Betsholtz, C., Tryggvason, K. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2 and 2310066E14Rik. J. Am. Soc. Nephrol. 18,689-697 (2007)

138

He, L., Sun, J., Patrakka, J., Mostad, P., Norlin, J., Xiao, Z., Andrae, J., Tryggvason, K., Samuelsson, T., Betsholtz, C., Takemoto, M. Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis. Kidney Int. 71,889-900 (2007)

**139 Hellström, M., Phng, L.-K., Hofmann, J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalén, M., Gerhardt, H., Betsholtz, C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445,776-780, (2007) 140

Cotta Doné, S., Takemoto, M., He, L., Sun, Y., Betsholtz, C., Tryggvason, K. Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int, 73,697-704 (2008)

141

He, L., Sun, Y., Takemoto, M., Norlin, J., Tryggvason, K., Samuelsson, T. and Betsholtz C. The glomerular transcriptome and a predicted protein-protein interaction network. J. Am. Soc. Nephrol. 19,260-268 (2008)

Curriculum Vitae

Christer Betsholtz

142

Van den Akker, N.M.S., Winkel, L.C.J., Nisancioglu, M.H., Maas, S., Wisse, L.J., Armulik, A., Poelmann, R.E., Lie-Venema, H., Betsholtz, C., and Gittenberger-de Groot, A.C. PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries and cardiac innervation. Dev Dyn 237,494-503 (2008)

143

Nisancioglu, M., Betsholtz, C and Genové, G. Generation and characterization of Rgs5 mutant mice. Mol Cell Biol, 28,2324-2331 (2008)

144

Su, E.J., Fredriksson, L., Geyer, M., Folestad, E., Cale, J., Mann, K., Gao, Y., Pietras, K., Andrae, J., Yepes, M., Strickland, D., Betsholtz, C., Eriksson, U., Lawrence, D.A. Activation of PDGF-CC by tissue plasminogen activator impairs blood brain barrier integrity during ischemic stroke. Nature Medicine, 14,731-737 (2008)

145

Wallgard, E., Larsson, E., He, L., Hellström, M., Nisancioglu, M., Genové, G., Lindahl, P., and Betsholtz, C. Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Atheroscler Thomb Vasc Biol. 28,1469-1476 (2008)

146

Tammela, T., Zarkada, G. Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., Freitas, C., Duarte, A., Isoniemi, H., Laakkonen, P., Christofori, G., Ylä-Herttuala, S., Shibuya, M., Pytowski, B., Eichmann, A., Betsholtz, C., Alitalo, K. Inhibition of VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454,656-660 (2008)

147

Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Li, X., Eriksson, U., and Pietras, K. Paracrine signaling by Platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res 69,369-378 (2009)

148

Sun Y., He, L., Takemoto, M., Patrakka, J., Pikkarainen, T., Genové, G., Norlin, J., Truvé, K., Tryggvason, K. and Betsholrz, C. Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria. Am J Nephrology 29,558-570 (2009)

149

Funa, N.S., Kriz, V., Zang, G., Calounova, G., Åkerblom, B., Mares, J., Larsson, E., Sun, Y., Betsholtz, C and Welsh, M. Dysfunctional microvasculature as a consequence of Shb gene inactivation causes impaired tumor growth. Cancer Res 69,2141-2148 (2009)

150

Salo, S., Boutard, A., Hansen, A.J., He, L., Morales, S., Venturi, A., Martin, P., Nokelainen, P., Betsholtz, C., Stenfeldt, I., and Tryggvason, K. Laminin-322 antibodies target carcinoma cells in vivo and inhibit tumor growth via induction of tumor cell apoptosis. Int J Cancer 125,18141825 (2009)

151

Ebarasi, L., He, L., Takemoto, M., Betsholtz, C., Tryggvason, K. Majumdar, A. A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol 334,1-9 (2009)

152

Nisancioglu, M., Betsholtz, C., and Genové, G. The absence of periytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade. Cancer Res 70,5109-5115 (2010)

153

Bax, N.A., Bleyl, S.B., Gallini, R., Wisse, L.J., Hunter, J., Van Oorschot, A.A., Mahtab, E.A., Lie-Venema, H., Goumans, M.J., Betsholtz, C., Gittenberger-de Groot, A.C. Cardiac malformations in Pdgfr-alpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field. Dev Dyn 239,2307-2317 (2010)

154

Xu, X., Patrakka, J., Sistani, L., Uhlen, M., Jalanko, H., Betsholtz, C., Tryggvason, K.

Curriculum Vitae

Christer Betsholtz

Expression of novel podocyte-associated protein sult1b1 and ankrd25. Nephron Exp Nephrol 117,e39-e46 (2010) **155 Armulik, A., Genové, G., Mäe, M., Nisancioglu, M.H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., Johansson, B.R., Betsholtz, C. Pericytes regulate the blood-brain barrier. Nature 468,557-561 (2010) 156

Kutchera, S., Weber, H., Weick, A., De Smet, F., Genove, G., Takemoto, M., Prahst, C., Riedel, M, Mikelis, C., Baulande, S., Champseix, C., Kummerer, P., Conseiller, E., Multon, M.C., Heroult, M., Bicknell, R., Carmeliet, P., Betsholtz, C., Augustin, HG. Differential endothelial transcriptomics identifies semaphoring 3G as a vascular class 3 semaphorin. Atheroscler Thomb Vasc Biol. 31,151-159 (2011)

157

Xiao, Z., He, L., Takemoto, M., Jalanko, H., Chan, G.C., Storm, D.R., Betsholtz, C., Tryggvason, K., Patrakka, J. Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria. Nephron Exp Nephrol 118,e39-e48 (2010)

158

Rymo, S., Gerhardt, H., Wolfhagen Sand, F., Lang, R., Uv, A., Betsholtz, C. A two-way communication between microglial cells and angiogenic sprouts regulate s angiogenesis in aortic ring cultures. PLoS One 6:e15846 (2011)

159

He, B., Ebarasi, L., Hultenby, K., Tryggvason, K., Betsholtz, C. Podocin-green fluorescent protein allows visualization and functional analysis of podocytes. J Am Soc Nephrol 22,10191023 (2011)

160

Raines, S.M., Richards, O.C., Schneider, L.R., Schueler, K.L., Rabaglia, M.E., Oler, A.T., Stapelton, D.S., Genove, G., Dawson, J.A., Betsholtz, C, Attie, A.D. Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity. Am J Physiol Endocrinol Metab. 301,E517-526 (2011)

161

Sistani, L., Dunér, F., Udumala, S., Hultenby, K., Uhlén, M., Betsholtz, C., Tryggvason, C., Wernerson, A., Patrakka J. Pdlim2 is a novel actin-.regulating protein of podocyte foot processes. Kidney Int 80,1045-1054 (2011)

162

Nishibori, Y., Katayama, K., Parikka, M., Oddson A., Nukui, M., Hultenby, K., Wernerson, A., He, B., Ebarasi, L., Raschperger, E., Norlin, J., Uhlén, M., Patrakka, J., Betsholtz, C., Tryggvason, K. Glcc1 deficiency leads to proteinuria. J Am Soc Nephrol 22,2037-2046 (2011)

163

Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainan T, Vainio S, Tryggvason K. Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn 240,2646- 2656 (2011)

164

Fredriksson L, Nilsson I, Su EJ, Andrae J, Ding H, Betsholtz C, Eriksson U, Lawrence DA. Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities. Am J Pathol. 180,1136-1144 (2012)

165

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holzman DM, Betsholtz C, Armulik A, Sällström J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity necessary for proper neuronal function via cyclophilin A. Nature, 485,512-516 (2012)

166

Persic L., Lal, M., Hulkko, J., Hultenby, K., Onfelt, B., Sun, Y., Dunér, F., Patrakka, J., Betsholtz, C., Uhlén, M., Brismar, H., Tryggvason, K., Wernerson, A., Pikkarainen, T. Plekkh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. Kidney Int, 82,1071 (2012)

Curriculum Vitae

167

Christer Betsholtz

Sistani, L., Rodriguez, P.Q., Hultenby, K., Uhlén, M., Betsholtz, C., Jalanko, H., Tryggvason, K., Wernerson, A., Patrakka, J. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. Kidney Int, 83,63 (2013)

**168 Gaengel, K., Niaudet, C., Hagikura, K., Siemsen, B.L., Muhl, L., Hofmann, J.J., Ebarasi, L., Nyström, S., Rymo, S., Chen, L.L., Pang, M.F., Jin, Y., Raschperger, E., Roswall, P., Schulte, D., Benedito, R., Larsson, J., Hellström, M., Fuxe, J., Uhlén, P., Adams, R., Jakobsson, L., Majumdar, A., Vestweber, D., Uv, A., Betsholtz, C. The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2. Dev Cell 23,587-99 (2012) 169

Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N. The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818

**170 Keller A, Westenberger A, Sobrido MJ, García-Murias M, Domingo A, Sears RL, Lemos RR, Ordoñez-Ugalde A, Nicolas G, da Cunha JE, Rushing EJ, Hugelshofer M, Wurnig MC, Kaech A, Reimann R, Lohmann K, Dobričić V, Carracedo A, Petrović I, Miyasaki JM, Abakumova I, Mäe MA, Raschperger E, Zatz M, Zschiedrich K, Klepper J, Spiteri E, Prieto JM, Navas I, Preuss M, Dering C, Janković M, Paucar M, Svenningsson P, Saliminejad K, Khorshid HR, Novaković I, Aguzzi A, Boss A, Le Ber I, Defer G, Hannequin D, Kostić VS, Campion D, Geschwind DH, Coppola G, Betsholtz C*, Klein C*, Oliveira JR*. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat Genet 28,1077 (2013) *shared last authors 171

Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C. Analysis of mice lacking the heparin-binding splice isoform of PDGF-A. Mol Cell Biol 33,430-40 (2013)

172

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 19,1617-24 (2013)

173

Neubauer B, Machura K, Rupp V, Tallquist MD, Betsholtz C, Sequeira-Lopez ML, Ariel Gomez R, Wagner C. Development of renal renin-expressing cells does not involve PDGF-BPDGFR-β signaling. Physiol Rep 2013 Oct;1(5):e00132. doi: 10.1002/phy2.132. Epub 2013 Oct 24.

174

Xiao Z, Rodriguez PQ, He L, Betsholtz C, Tryggvason K, Patrakka J. Wtip- and gadd45ainteracting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier. PLoS One. 2013 Dec 20;8(12):e83133. doi: 10.1371/journal.pone.0083133.

175

Rodin S, Antonsson L, Niaudet C, Simonson OE, Salmela E, Hansson EM, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson AS, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjöld M, Grinnemo KH, Kere J, Betsholtz C, Hovatta O, Tryggvason K. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun. 2014;5:3195. doi: 10.1038/ncomms4195. PMID: 24463987 [PubMed - in process]

176

He B, Ebarasi L, Zhao Z, Guo J, Ojala JR, Hultenby K, De Val S, Betsholtz C, Tryggvason K. Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. J Am Soc Nephrol. 2014 May 22. pii: ASN.2012080823. [Epub ahead of print] PMID: 24854274

Curriculum Vitae

Christer Betsholtz

[PubMed - as supplied by publisher] 177

Shang MM, Talukdar HA, Hofmann JJ, Niaudet C, Asl HF, Jain RK, Rossignoli A, Cedergren C, Silveira A, Gigante B, Leander K, Faire UD, Hamsten A, Ruusalepp A, Melander O, Ivert T, Michoel T, Schadt EE, Betsholtz C, Skogsberg J, Björkegren JL. Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014 Jun 12. pii: ATVBAHA.113.302709. [Epub ahead of print] PMID: 24925974 [PubMed - as supplied by publisher]

178

Saeed AA, Genove G, Li T, Luetjohann D, Olin M, Mast N, Pikuleva IA, Crick P, Wang Y, Griffiths W, Betsholtz C, Björkhem I. J Biol Chem. 2014 Jun 27. pii: jbc.M114.556159. Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. [Epub ahead of print] PMID: 24973215 [PubMed - as supplied by publisher]

179

Andrae J., Gouveia, L., He, L., Betsholtz, C. Characterization of platelet-derived growth factorA expression in mouse tissues using a lacZ knock-in approach. Plos One, in press (2014).

2. Review articles and commentaries in peer-reviewed journals (** most important) 1

Hellman, B., Gylfe, E., Berggren, P-O., Andersson, T., Abrahamsson, H., Rorsman, P. and Betsholtz, C. Ca2+ transport in pancreatic ß-cells during glucose stimulation of insulin secretion. Upsala J Med Sci 85,321-329 (1980)

2

Heldin, C.-H., Westermark, B., Mellström, K., Johnsson, A., Ek, B., Nistér, M., Betsholtz, C., Rönnstrand, L. and Wasteson, Å. Platelet-derived growth factor: Structural and functional aspects. Surv Synth Path Res 1,153-164 (1983)

3

Heldin, C.-H., Betsholtz, C., Johnsson, A., Nistér, M., Ek, B., Rönnstrand, L., Wasteson, Å. and Westermark, B. Platelet-derived growth factor - mechanism of action and relation to oncogenes. J Cell Sci 3,65-76 (1985)

4

Heldin, C.-H., Betsholtz, C., Johnsson, A. and Westermark, B. Role of PDGF-like growth factors in malignant transformation. Cancer Rev 2,34-47 (1986)

5

Heldin, C.-H., Betsholtz, C., Claesson-Welsh, L. and Westermark, B. Subversion of growth regulatory pathways in malignant transformation. Biochim Biophys Acta Cancer Rev 907,219244 (1987)

6

Betsholtz, C., Johnson, K.H. and Westermark, P. "Amylin" Correspondence) Nature 338,221 (1989)

7

Betsholtz, C., Nistér, M., Rorsman, F., Heldin, C.-H. and Westermark, B. Structural and functional aspects of platelet-derived growth factor and its role in the pathogenesis of glioblastoma. Mol Chem Neuropathol 10,27- 36 (1989)

8

Johnson, K.H., O'Brien, T.D., Betsholtz, C. and Westermark, P. Islet amyloid, islet amyloid polypeptide and diabetes mellitus. New Engl J Med 321,513-518 (1989)

9

Betsholtz, C., Rorsman, F., Westermark, B., Östman, A. and Heldin, C.-H. Analogous alternative splicing (Scientific correspondence) Nature 344,299 (1990)

hormone

(Scientific

Curriculum Vitae

Christer Betsholtz

10

Westermark, P., Johnson, K.H. O ́Brien, T.D.and Betsholtz, C. Islet amyloid polypeptide - a novel controversy in diabetes research. Diabetologia 35,297-303 (1992)

11

Johnson, K.H., O'Brien, T.D., Betsholtz, C. and Westermark, P. Islet amyloid polypetide (IAPP): Mechanisms of amyloidogenesis in pancreatic islets and potential roles in diabetes mellitus. Lab. Invest 66,522-535 (1992)

12

Betsholtz, C., Christmanson, L., Gebre-Medhin, S. and Westermark, P. Islet amyloid polypetide - hen or egg in type 2 diabetes pathogenesis? Acta Oncologica 32,149-154 (1993)

13

Betsholtz, C. Role of platelet-derived growth factors in mouse development. Int. J. Dev. Biol. 39, 817-825 (1995)

14

Betsholtz, C. and Raines, E.W. Platelet.dericed growth factor - a key regulator of connective tissue cells. Kidney Int. 51,1361-1369 (1997)

15

Lindahl, P., Betsholtz, C. Not all myofibroblasts are alike: Revisiting the role of PDGF-A and PDGF-B using PDGF targeted mice. Curr. Opin. Nephrol. Hypert. 7: 21-26 (1998)

16

Lindahl, P., Hellström, M., Kalén, M. and Betsholtz, C. Endothelial-perivascular cell signaling in vascular development: lessons from knockout mice: implications for vascular biology. Curr. Op. Lipidology, 9: 407-411 (1998)

17

Lindahl, P., Boström, H., Karlsson, L., Hellström, M., Kalén, M. and Betsholtz, C. Role of platelet-derived growth factors in angiogenesis and alveogenesis. Curr Top Pathol. 93:27-33 (1999)

18

Betsholtz, C. Platelet-derived growth factors (PDGFs). Regulators of multiple developmental processes. J. Clinical Ligand Assays 23:206-213 (2000)

19

Betsholtz, C., Karlsson, L. and Lindahl, P. Developmental roles of platelet-derived growth factors. BioEssays 23:494-507 (2001)

20

Gerhardt, H., and Betsholtz, C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 314:15-23 (2003)

21

Betsholtz, C. Biology of platelet-derived growth factors in development. Birth Defects Res Part C Embryo Today 69, 272-285 (2003)

22

Betsholtz, C., Lindblom, P., Bjarnegård, M., Enge, M., Gerhardt, H., and Lindahl P. Role of PDGF in mesangium development and vasculopathies: lessons from PDGF and PDGF receptor mutant mice. Curr Op Nephrol Hypertens 13,45-52 (2004)

23

Betsholtz, C. Insight into the physiological functions of PDGF through genetic studies in mice. Cytokine Growth Fact Rev, 15:215-228 (2004)

**24 Armulik, A., Abramsson, A., Betsholtz, C. Endothelial/Pericyte interactions. Circ Res 97: 512523 (2005) **25 Von Tell, D., Armulik, A. and Betsholtz, C. Pericytes and vascular stability. Exp Cell Res. 312,623-629 (2005) 26

Betsholtz. C., and Armulik, A. Homeostatic functions of vascular endothelial growth factor in the adult microvasculature. Am J Physiol Heart Circ Physiol 290:H509-H511 (2006)

Curriculum Vitae 27

Christer Betsholtz

Betsholtz, C., He, L., Takemoto, M., Norlin, J., Sun, Y., Patrakka, J., Tryggvason, K. The glomerular transcriptome and proteome. Nephron Exp Nephrol, 106,32-36, (2007)

**28 Andrae, J., Gallini, R., and Betsholtz, C. Role of platelet-derived growth factor in physiology and medicine. Genes Dev, 22,1276-1312 (2008) **29 Gaengel, K., Genové, G., Armulik, A., and Betsholtz C. Endothelial-mural cell signaling in vascular development and angiogenesis Atherscler Thomb Vasc Biol. 29,630-638 (2009) 30

Ebarasi, L., Oddsson, A., Hultenby, Betsholtz, C., Tryggvason, K. Zebrafish: a model system for the study of vertebrate renal development, function and pathophysiology. Curr Opin Nephrol Hypertens 20,416-424 (2011)

**31 Armulik, A., Genové, G., Betsholtz, C. Pericytes: developmental, physiological and pathological perspectives, problems and promises. Dev Cell 21,193-215 (2011) 32

Mäe M, Armulik A, Betsholtz C. Getting to know the cast - cellular interactions and signaling at the neurovascular unit. Curr Pharm Des. 17, 2750-2754, (2011)

33

Arnold T, Betsholtz C. The importance of microglia in the development of the vasculature in the central nervous system. Vasc Cell. 2013 Feb 19;5(1):4. doi: 10.1186/2045-824X-5-4.

34

Gaengel K, Betsholtz C. Endocytosis regulates VEGF signalling during angiogenesis. Nat Cell Biol. 2013 Mar;15(3):233-5. doi: 10.1038/ncb2705.

35

Betsholtz C. Physiology: Double function at the blood-brain barrier. Nature. 2014 May 22;509(7501):432-3. doi: 10.1038/nature13339. Epub 2014 May 14. No abstract available. PMID: 24828036 [PubMed - indexed for MEDLINE]

36

Betsholtz C, Keller A. PDGF, pericytes and the pathogenesis of idiopathic basal ganglia calcification (IBGC). Brain Pathol. 2014 Jul;24(4):387-95. doi: 10.1111/bpa.12158. PMID: 24946076 [PubMed - in process]

3. Review articles in non-peer reviewed journals, books and book chapters 1

Betsholtz, C., Heldin, C.-H., Wasteson, Å and Westermark, B. Pure platelet-derived growth factor stimulates human fibroblasts to proliferate in plasma-free culture. In: Hormonally Defined Media. (Eds. Fisher, G. and Wieser, R.W.) Proceedings in Life Sciences. SpringerVerlag. pp103-106 (1983)

2

Westermark, B., Johnsson, A., Betsholtz, C., Wasteson, Å. and Heldin, C.-H. Platelet-derived growth factor: Comments on the structural and functional relationship with the transforming protein of simian sarcoma virus. In: Molecular Biology of Tumor Cells. Raven Press, New York (Eds Wahren, B. et al.) pp 87-94 (1985)

3

Betsholtz, C. Role of platelet-derived growth factor in neoplastic transformation. PhD Thesis. Comprehensive summaries of Uppsala dissertations from the faculty of medicine 23, 1-54 (1986)

4

Westermark, B., Johnsson, A., Betsholtz, C. and Westermark, B. Biological properties of simian sarcoma virus and its oncogene product. In: Contributions to Oncology. (Eds. Eckhardt et al.) Karger, Basel. 24,51-61 (1987)

5

Westermark, B., Betsholtz, C., Johnsson, A. and Heldin, C.-H. Acute transformation by simian

Curriculum Vitae

Christer Betsholtz

sarcoma virus is mediated by an externalized PDGF-like growth factor. In: Viral Carcinogenesis (Eds Kjeldhard, N.O. and Forchhommer, J.) Munksgaard, Copenhagen, pp 445454 (1987) 6

Betsholtz, C., Johnsson, A., Heldin, C.-H. and Westermark, B. The two platelet-derived growth factor genes and their products. In: Proceedings of the 14th UI Cancer Congress. (1987)

7

Westermark, B., Betsholtz, C., Claesson-Welsh, L., Nistér, M. and Heldin, C.-H. Molecular mimicry within the platelet-derived growth factor family: Identification of three isoforms that bind to two distinct but related cell surface receptors. In: Molecular mimicry in health and diesease (Eds Lernmark, Å. et al.) Excerpta Medica, Amsterdam, New York, Oxford. pp. 135146 (1988)

8

Betsholtz, C., Rorsman, F., Bywater, M., Heldin, C.-H. and Westermark, B. Platelet-derived growth factor: structural and functional aspects of the A-chain gene. In: Advances in Growth Hormones and Growth Factor Research (Eds. Müller et al.) Pythagora Press, Roma-Milano and Springer Verlag, Berlin-Heidelberg pp. 181-190 (1989)

9

Nistér, M., Betsholtz, C., Heldin, C.-H. and Westermark, B. Platelet-derived growth factor. In: Growth factors and Oncogenes. (Eds. Bolla, M. et al.) Colloque INSERM/John Libbey Eurotext Ltd. 190,25-33 (1989)

10

Betsholtz, C., Nistér, M., Heldin, C.-H. and Westermark, B. Platelet-derived growth factor: Role in gliogenesis and in the development of glioblastoma. In: Trophic Factors and the Nervous System. (Ed. Horrocks, L.et al.) Raven Press Ltd, New York. pp35-45 (1990)

11

Westermark, P. Betsholtz, C., Dominguez, H., O'Brien, T.D. and Johnson, K.H. Islet amyloid polypeptide (IAPP) in humans and cats. In: Frontiers in diabetes reaearch. Lessons from animal diabetes III (Ed E. Shafrir) Smith-Gordon pp498-501 (1990)

12

Westermark, B., Betsholtz, C. and Hökfelt, B (Eds). Growth factors in health and disease. Basic and Clinical aspects. Elsevier Science Publishers, Amsterdam. (1990)

13

Grafström, R., Brismar, K. and Betsholtz, C (eds). Physiological, pharmacological and toxicological aspects on growth factors. Acta Pharm Nord Suppl 1.90 pp36-42 (1990)

14

Betsholtz, C., Christmansson, L., Rorsman, F., Svensson, V., Stenman, G., Johnson, K.H. & Westermark, P. Islet amyloid polypeptide (IAPP): structure of its cDNA and gene and the identification of species differences of importance for islet amyloid formation. In: Amyloidosis (eds. Natvig, J.B. et al) Kluwer Academic Publishers, Dordrecht/Boston/London.pp433-436 (1991)

15

Christmanson, L., Betsholtz, C., Johansson, B. and Westermark, P. The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis. In: Amyloidosis (eds. Natvig, J.B. et al) Kluwer Academic Publishers, Dordrecht/Boston/london. pp635-638 (1991)

16

Johnson, K.H., Jordan, K., O'Brien, T.D., Murtaugh, M.P., Wernstedt, C., Betsholtz, C. and Westermark, P. Factors affecting diabetogenesis and amyloidogenesis are provided by studies of IAPP in the dog and cat. In: Amyloidosis (eds. Natvig, J.B. et al.) Kluwer Academic Publishers, Dordrecht/Boston/London, pp445-448 (1991)

17

Westermark, P., Johnson, K.H., Engström, U., Westermark, G.T., Domingues, H., Christmanson, L. and Betsholtz, C. Islet amyloid polypeptide: Synthetic peptides for the study of the pathogenesis of islet amyloid. In: Amyloidosis (eds. Natvig, J.B. et al.) Kluwer Academic Publishers, Dordrecht/Boston/London, pp449-452 (1991)

Curriculum Vitae

Christer Betsholtz

18

Westermark, P ., Betsholtz, C., Westermark, G.T ., Christmanson, L., O'Brien, T .D. and Johnson, K.H. Islet amyloid and islet amyloid poly-peptide. In: Diabetes 1991 (Eds. Rifkin, H., Colwell, J.A. and Taylor, S.I.) Elsevier press pp501-504 (1991)

19

Betsholtz, C. The PDGF genes and their regulation. In: Cytokines Vol 5 (Eds B. Westermark, C. Sorg) Karger, Baselin 5,11-30 (1992)

20

O'Brien, T.D., Westermark, P., Betsholtz, C. and Johnson, K.H. Islet amyloid polypeptide: biology and role in the pathogenesis of islet amyloidosis and diabetes mellitus. In: Lessons in animal diabetes (Ed. E. Shafrir) in press (1993)

21

Betsholtz, C. The biology of platelet-derived growth factor. In: New perspectives in endocrinology (eds De Bellis, A. and Marschke, K.B.) Raven press, New York, vol 99 pp 281291 (1993)

22

Betsholtz, C. Platelet-derived growth factor: current views on its normal and pathological functions in vivo. In: Pulmonary Fibrosis (Ed. Phan, S and Thrall, R.). Lung Biology in Health and Disease, Marcel Dekker, inc. New York/basel/Hong Kong. Volume 80, pp647-674 (1994)

23

Betsholtz, C. and Heldin, C.-H. Platelet-derived growth factor: A regulator of connective tissue development and reaction. In: Connective Tissue Biology. Integration and Reductionism. Reed, R.K. and Rubin, K. eds. Wenner-Gren International Series Volume 71. Portland Press. pp179193 (1997)

24

Mulder, H., Ahrén, B., Ekblad, E., Gebre-Medhin, S., Betsholtz, C., Sundelin, J., Westermark, G.T., Westermark, P. and Sundler, F. Islet amyloid polypeptide and adrenomedullin: Novel peptide hormones expressed in the gastro-entero-pancreatic region. In: Gastrointestinal Endocrinology, Ed Greeley, G.H. Humana Press, Totowa, NJ (1999)

25

Takemoto, M., Asker, N. And Betsholtz, C. New methods for large scale isolation of kidney glomeruli from mice. DYNALogue 01/2003: 8-9 (2003).

26

Gerhardt, H. and Betsholtz, C. High resolution in situ confocal analysis of endothelial cells. In: Methods in Endothelial Cell Biology, Ed. H. Augustin, Springer Verlag. pp 313-324 (2004)

27

Betsholtz, C and Gerhardt, H. Role of platelet-derived growth factors in the microvasculature. In ” Microvascular Research: Biology and Pathology” Ed D Shepro & P DʼAmore. Elsevier Press. pp 85-90 (2005)

28

Gerhardt, H and Betsholtz C. How do endothelial cells orientate? In ”Mechanisms of Angiogenesis” Ed M Klauss et al. EXS 94: 3-15 (2005)

29

Betsholtz, C., Lindblom, P and Gerhardt, H. Role of pericytes in vascular morphogenesis. In: ”Mechanisms of Angiogenesis” Ed M Klauss et al. EXS 94:115-125 (2005)

30

Kurup, S., Abramsson, A., Li, J.P., Kjellén, L., Betsholtz, C., Gerhardt, H., Spillmann, D. Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. Biochem. Soc. Transact. 34,454-455 (2006)

31

Asp, J., Abramsson, A. and Betsholtz C. Non-radioactive in situ hybridization on frozen sections and whole mounts. Methods Mol Biol 326,89-102 (2006)

32

Östman A., and Betsholtz C. PDGF: impact on physiological and tumor angiogenesis. In: Tumor Angiogenesis. Eds: Marme D., and Fusenig N. Springer. In press (2007)

Curriculum Vitae

Christer Betsholtz

33 Lundkvist A., Lee S., Iruela-Arispe, L., Betsholtz, C., Gerhardt, H. Growth factor gradients in vascular patterning. Novartis Found Symp 283,194-201 (2007) 34

Armulik, A., and Betsholtz, C. Role of pericytes in vascular biology. In “Pathogenesis of Diabetic Retinopathy – An Update 2006” Eds Porta, M., and Hammes, H.-P. Frontiers in Diabetes, Karger (2008)

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