1391/10/20 :
1392
1391/12/26 :
#$ "
!/232
/
! " #$ 3
2
1
%$ & ! ' 1 2 3 45 6 # - %. / 0* ! " # $ !% & ' ( ) "*+ ! , . : ? @. =A6 B C + ) ! , D>75 . . ,Adhesion molecule = ,$ 5 *7 8 # 0* ! , *5 ) ( 45 & 9& # :;< Angiotensin converting enzyme inhibitors) $ & H ? I6; ( ? ! ,A6775 0 ! , :"F = )G . A6 D E 3 4# Q*; "# # 0* 6L ! ,$ 5 * 2L. M 'N O # =42 3 $ B C P6, .6 # , ? # 0* 6L 2) (ACEIs . # U 40
, ! ". # 4 S . M 'N B D : 10 ( C& = " . 6, # 5 . !A6 ) R& 7 # ? 5$ : " # B "& B (IL-13) 13 $ 5 *7 . (IL-10) 10 $ 5 *7 =(IL-4) 4 $ 5 *7 ( . ) D B C A . ! # 4# Q*; " # .6 ! DA 6 2 . 0 ! ,A
. ) !
72 > () M 'N #
W'
A. D
(P < 0/001) IL-13 . (P < 0/001) IL-10 =(P = 0/001) IL-4
> () O 6 & # 0* 6L O $ X6 # OY !62# 1Q"+ C W 6 & -1
"
" #$% " #
%$! & '( )
"
" #$% " #
%$! & '( )
Email:
[email protected]
1392
4-72 -
; # %< *! # =9 :
H @ D< S(1-2) "
(' A6 ] 4:C .
.(1)
H @ GK
M%
@
" @ ! @ ^+ : !
" /DA
/ $ 0 %!
# /
=B :&.6 :
* :;7 =^ S
424-432 :(232) 31 X1392 0U_
A F .
S :
! !
+ ,
-. -2
0'1
-. -3
:
/ 31
424
– www.mui.ac.ir
"#
%$F
$ @ w D #% X q 7 ZA . hD
w D 1RE 7"
(version 16, SPSS Inc., Chicago, IL) 16 #%WX
#
% (IL-13) 13 @ ! N D $ (IL-10) 10 @ ! N D
uI :# F - M0.
hD
nd
% GN d -
=
NSAIDs $ Ergotamines Triptan H A % #
# = G J R' Aura $ & @
% .DR
h 6.
.
% GN d
( 2 85) )8
h 34 $
34/42 ± 1/82
%
/ @ . 1 RE
& CK
"%
h 19 $ %*
/
'%
@
$ >
.7
F 1 # / 8$ A 7 M*+ H @
1392
!" # $ /232
v
D
'
1
! /
R #
hD %*/0 e =
! # >i I #$
% GN d
/ ^$
#%&
$ >
H - tK = $ %*
$>
%M0.
R A{ "
$ %
/ 40
;
=%
$
e ;
1 RE 7"
hD
=7 /!
# $ =
2
BF =$
I
7ZA
5
%D& > IL-13 $ IL-10 IL-4 15 ( =.
K
%2 K $ >$ D
# > 426
– www.mui.ac.ir
"#
%$# >i I
h*DW # =$
%!
E
% D& >
β-blocker # =$
2 # =%D
K
= F #% */A .(13-14)
*RE # =$
2
-
G
tK =
$
K
= F @ K,Z
II @ X K B F (
#
7 M*+ H
IL-10
#
A
7 :K #% *
%!
7& iH& #
>#=
!
2
A$
# > *A #U N
# >i I
=$
%D
% DRN S
-
@ .7
tK
/ kW
.(P = 0/270)
j ( U N H &$
/ kW
.(10-11) hD
'%
IL-4
.(P = 0/821)
7 & iH & #
$ Calcium channel blocker
9 * $ ACEIs % !
7 :K #% *
-./0
A#= %& b
'%
hD
%
b # =$
*!
! $ !
F !@
Z (
$ &
N
" % 1 Il
% (ACEI) @ X K B F
e
ZDN # = .
'
! #'( ) !
< 7 Gb$ %
.1
P #
0/075
!"
0/230
P
0/821
#
!"
14/646 ± 1/206 14/535 ± 1/323
P
0/001
#
!"
15/432 ± 1/499 14/048 ± 1/185 (IL-4) 4 )*+,- #./ (pg/ml)
0/114
0/112
0/177
19/750 ± 1/564 18/119 ± 4/014 < 0/001 20/559 ± 1/590 16/193 ± 2/004
10 )*+,- #./ (IL-10) (pg/ml)
0/590
0/185
0/270
18/964 ± 7/793 16/811 ± 1/438 < 0/001 17/971 ± 1/953 14/474 ± 1/350
13 )*+,- #./ (IL-13) (pg/ml)
427
1392
!" # $ /232
www.mui.ac.ir
/ 31
–
"#
%$iq F 7 RzK $ ( K$ *
$ KF 9.I ; % ;
ZDN b - j
ACEIs
#
N$ (26) 7 @
/
GdE
RZ
ZDN b - j @
1 Il #$ .
=8 N
j .(27)
!
$7
$ Y ZDN
1 N @ /= % S
$
/
>$
E$ " - R*E #
< (17)
/Z
'% = F#=
$ } ACEIs
E$ " - R*E { " i= ! %! 7q q0 @
h*DW - GN d N @
$
=
%!7
&
h
A$ = F H
#%/=
.(17-19)
F !%
" @ o/= $
*/" 8.D
=@ ! D
N
E$ " -#H t $
=
j %GN d @
( U N KI$( U N H&#=
%
ZDN b # =@ ! D
i q % ! DX= @
$
IL-10
H
7R X F %! $
%
iH& . D Fi H&
H
=
$
tK
D H
F7
E$
/ @
G
'% .
K
ZDN # =7 N G& ZDN i I .
c '@
N
.7 %D
=@ ! N D @ nd
A
j•
nd
-$ hK 1 N
=8 N @
mC ,=
H
# &
*RE - GN d
% ( H $ % D& i H&
IL-4 nd
N$ (37-38) 7
tK -. /0 @
%D
# Kl
$ -. /0 .(38-39) 7 %D
%&
R D% /
.7 H
K
K$ hD w D V*DW - GN d %
TNF-α
$
> ( :K
% .D R
@
IL-13 $ IL-4
# =@ ! N D #%d
*!
/ @ -./0
8 /D0 .(37)
Z
# =
1 Il m C 8 R % # b- j %
%* q #
m =
HI e *"
Z" 288239 # /
