‫ המועצה המדעית‬- ‫ההסתדרות הרפואית בישראל‬ ISRAEL MEDICAL ASSOCIATION – SCIENTIFIC COUNCIL ISRAEL NEUROLOGICAL ASSOCIATION

‫תוכנית הכינוס השנתי‬ ‫של האיגוד הנוירולוגי הישראלי‬

PROGRAM & ABSTRACTS

TEL-AVIV, 6-7 JANUARY 2009

‫האיגוד הנוירולוגי בישראל‬

‫ההסתדרות הרפואית בישראל * המועצה המדעית‬ ISRAEL MEDICAL ASSOCIATION – SCIENTIFIC COUNCIL ISRAEL NEUROLOGICAL ASSOCIATION

‫האיגוד הנוירולוגי בישראל‬

‫תוכנית הכינוס השנתי‬ ‫של האיגוד הנוירולוגי הישראלי‬

PROGRAM & ABSTRACTS Editor: Prof. Avinoam Reches

Scientific Committee: Prof. Rivka Inzelberg (Chairperson) Prof. Ruth Djaldetti Prof. David Tanne Prof. Alexander Lossos Dr. Ronit Gilad Dr. Itzhak Schiller

TEL-AVIV, 6-7 JANUARY 2009

ANNUAL MEETING OF THE ISRAEL NEUROLOGICAL ASSOCIATION

Tuesday, January 6 , 2009 08:00-09:00 09:00-10:45

Registration FIRST SESSION Chairpersons:

No 1

09:00-09:15

Dr. Ilan Blatt Dr. Felix Bokstein

Kan I, Melamed E, Green P, Offen D THE ROLE OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN THE INDUCTION OF BONE MARROW MESENCHYMAL STEM CELLS INTO NEURAL PROGENITOR CELLS FO R TREATMENT OF NEURODEGENERATIVE DISORDERS

2

09:15-09:30

Cohen ME, Muja N, Zhang J, Gilad AA, Walczak P, Bulte JMW, Ben-Hur T MIGRATION AND INTEGRATION OF TRANSPLANTED NEURAL PRECURSOR CELLS IN A MODEL OF MULTIPLE SCLEROSIS

3

09:30-09:45

Gan-Or Z, Bar-Shira A, Kedmi M, Gurevich T, Giladi N, OrrUrtreger A DIFFERENTIAL GENE EXPRESSION IN PARKINSON'S DISEASE PATIENTS CARRIERS OF MILD VERSUS SEVERE GBA MUTATIONS; A WHOLE-GENOME ANALYSIS

4

09:45-10:00

Inspector M, Manor D, Amir N, Gogol Y, Kushnir T, Karni A CHANGING THE PROSODIC FOCUS OF REPEATED SPOKEN SENTENCES ENHANCES ACTIVATION OF BILATERAL ANTERIOR TEMPORAL CORTEX (ATC) & RIGHT POSTERIOR MIDDLE TEMPORAL GYRUS (PMTG)

5

10:00-10:15

Karussis D, Karageorgiou C, Gowda-Kurkalli B, Vaknin-Dembinsky A, Kassis I, Petrou P, Ben-Hur T, Slavin S SAFETY, PHASE I/II STUDY WITH INTRATHECAL AND INTRAVENOUS INJECTION OF MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS AND AMYOTROPHIC LATERAL SCLEROSIS

6

10:15-10:45

Koton S, Tanne D, Green MS, Bornstein NM MORTALITY AND PREDICTORS OF DEATH ONE MONTH AND THREE YEARS AFTER ISCHEMIC STROKE: DATA FROM THE FIRST NATIONAL ACUTE STROKE ISRAELI SURVEY (NASIS 2004)

10:45-11:45

POSTER SESSION & Coffee Break POSTERS # 31-50

-A-

11:45-13:00

SECOND SESSION Chairperson: Prof. Rivka Inzelberg Dr. Yitzhak Schiller

11:45-12:30

Itzhak Fried MD,,, PhD Professor of Neurosurgery Tel- Aviv Sourasky Medical Center and UCLA IMAGE AND MEMORY: SINGLE NEURON RECORDINGS IN THE HUMAN TEMPORAL LOBE

12:30-13:00

Avinoam Reches M.D. BRAIN DEATH: NEW PROTOCOL - OLD DILEMMAS

13:00-14:30

Lunch Break

-B-

14:30-17:00

No 7

14:30-14:45

THIRD SESSION Chairpersons: Dr Arnon Karni Dr Yaron River

Bar-Shira A, Giladi N, Gan-Or Z, Gurevich T, Orr-Urtreger A THE LRRK2 G2019S MUTATION IN PARKINSONS DISEASE PATIENTS OF ASHKENAZI AND NON-ASHKENAZI ORIGIN - AN UPDATE

8

14:45-15:00

Dabby R, Silver-Leshinsky E, Cohen S, Inbar S, Sadeh M NAV1.7 SODIUM CHANNEL MUTATIONS AND NOVEL NEUROPATHIC PAIN SYNDROMES

9

15:00-15:15

Schiller Y SEIZURE RELAPSE AND DEVELOPMENT OF DRUG-RESISTANCE FOLLOWING LONG-TERM SEIZURE REMISSIONS

10

15:15-15:30

Lahiani I, Haber EP, Grigoriadis N, Lourbopoulos A, Abramsky O, Rosenmann H ENVIRONMENTAL-ENRICHMENT AMELIORATES THE NEUROFIBRILLARY- TANGLE PATHOLOGY IN A TRANSGENIC MODEL FOR TAUOPATHY/ALZHEIMER'S-DISEASE

11

15:30-15:45

Leker RR, Khouri S, Tanne D, Shwartz R, Eichel R on behalf of the NASIS investigators PRIOR USE OF STATINS IMPROVES OUTCOME IN PATIENTS WITH INTRACEREBRAL HEMORRHAGE: PROSPECTIVE DATA FROM THE NATIONAL ACUTE STROKE ISRAELI SURVEYS (NASIS)

12

15:45-16:00

Glik A, Kopelman M, Grinberg S, Shelef I INTRACRANIAL NON-JUGULAR VENOUS PATHWAYS: A POSSIBLE COMPENSATORY DRAINAGE MECHANISM

13

16:00-16:15

Eichel R, Liberman A, Arkadir D, Cohen J, Yitshaiek E, Gomori JM, Leker RR MULTI-MODAL ENDOVASCULAR REPERFUSION ANTERIOR CIRCULATION STROKE

14

16:15-16:30

THERAPY

IN

Nitsan Z, Hassin-Baer S , Strauss H, Spiegelmann R, Cohen OS DEEP BRAIN STIMULATION FOR DYSTONIA: FOLLOW UP AT SHEBA MEDICAL CENTER

15

16:30-16:45

Gurevich T, Mirelman A, Alroey I, Zilberstein T, Orr-Urtreger A, Giladi N MUTATIONS IN THE LRRK2 (G2019S) AND THE GLUCOCEREBROSIDASE GENES CAN INFLUENCE THE CLINICAL COURSE AND PRE-MORBID BEHAVIOR OF PATIENTS WITH PARKINSON'S DISEASE

16

16:45-17:00

Bokstein F, Aisenstein O, Ben Bashat D, Artzi M, Ram Z, Kanner AA, Corn BW, Blumenthal DT CALCIFICATION IN HIGH GRADE GLIOMAS TREATED WITH BEVACIZUMAB

-C-

17:30-18:30

‫אתנחתא מוסיקלית‬

"‫שמיניית הג'אז "הסיבוב השני‬ ‫ סקסופון טנור‬- ‫עו"ד אבירם בורוכוב‬ ‫ סרומבון‬- ‫דר' שי דגן‬ ‫ סקסופון אלט וסופרן‬- ‫אורן קונפורטי‬ ‫ שירה‬- ‫דר' שרון חסין‬ ‫ חצוצרה‬-‫דר' עוזי מלמד‬ ‫ תופים‬- ‫פרופ' אבי עורי‬ ‫ קונטרבאס‬-‫שי פקר‬ ‫ פסנתר‬- ‫דר' חן קוגל‬

18:30-19:00 19:00-21:00

Light Dinner UPDATE IN CLINICAL NEUROLOGY: Autonomic NervousNervousNervous System Generously sponsored by: NOVARTIS JANSSEN CILAG TARO MSD MEDISON RAFA Chairperson: Dr. Tania Gurevich Dr Yishai Ron, Director Neurogastroenterology & Motility Service, Dept. of Gastroenterology, The Tel-Aviv Sourasky Medical Center "DIGESTION THROUGH THE NEUROLOGICAL PRISM"

Prof. Yoram Vardi, Director Neuro-Urology Unit, Rambam, Health Care Campus “CONTINENCE: WHAT IN IT FOR NEUROLOGIST?”

Tanya Gurevich , Director Parkinson Disease and Neuroautonomic Service, Department of Neurology,Tel Aviv Medical Center “WHAT MAKES US FAINT? SECRETS OF BIPEDALS”

-D-

Wednesday, January 7, 2009 08:30-10:30

FOURTH SESSION Chairpersons:

No 17

08:30-08:45

Dr Ronit Gilad Dr Colin Klein

Haion Y, Varon D, Shay E, Chernoguz D, Leker RR PLATELET MICROPARTICLES NEUROGENESIS AFTER STROKE

18

08:45-09:00

INDUCE

ANGIOGENESIS

AND

Kleiner-Baumgarten A, Ifergane G, Wirguin I LONG TERM INTRAVENOUS IMMUNOGLOBULIN THERAPY IN CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

19

09:00-09:15

Thau Zuchman O, Shohami E , Leker RR VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES ANGIOGENESIS AND NEUROGENESIS NEUROPROTECTION, FOLLOWING CLOSED HEAD INJURY

20

09:15-09:30

Sajin A, Schwartz I, Tsenter J, Yovchev I, Rephaeli G, Aichel R, Cohen J, Meiner Z, Leker RR LONG TERM EFFECTS OF THROMBOLYSIS TREATMENT ON FUNCTIONAL OUTCOME

21

09:30-09:45

Cohen-Yeshurun A, Trembovler V, Alexandrovich A, Mechoulam R, Shohami E, Leker RR A NOVEL ENDOCANNABINOID EXERTS NEUROPROTECTION IN A NON-CB1-MEDIATED MECHANISM

22

09:45-10:00

Israel Z, Spivak A, Moskowiczi S, Linetzky E, Neeman Y, Roemi L, T Moller, Reches A, Zaidel A, Bergman H DEEP BRAIN STIMULATION FOR PARKINSON’S DISEASE. A SIX YEAR SINGLE CENTER EXPERIENCE

10:00-11:00

POSTER SESSION & COFFEE BREAK POSTERS # 51-70

-E11:00-13:00

BUSINESS MEETING

13:00-14:00

Lunch Break

14:00-16:00

FIFTH SESSION Chairpersons:

No 23

14:00-14:15

Dr Roni Milo Dr. Baruch Elad

Wirguin I PARTIAL RESPONSE OF DYSFERLINOPATHY PATIENTS TO LOW DOSE DANTROLENE SODIUM TREATMENT

24

14:15-14:30

Gotkine M, Rozenstein L, Evron T, Einstein O, Abramsky O, Argov Z, Soreq H, Rosenmann H ACETYLCHOLINESTERASE IS OVEREXPRESSED IN ALS MICE AND ANTISENSE INHIBITION PROLONGS SURVIVAL

25

14:30-14:45

Offen D, Sadan O, Melamed E INDUCED MESENCHYMAL STROMAL CELLS ATTENUATE 6-OHDAINDUCED STRIATAL LESIONS IN A RAT MODEL OF PARKINSON'S DISEASE

26

14:45-15:00

Tsenter J, Meiner Z and all the rehabilitation teams BOTULINUM TOXIN TREATMENT FOR SPASTICITY AFTER STROKE

27

15:00-15:15

Shirvan A, Reshef A, Allen AM, Fenig E, Steinmetz A ,Groshar D, Inbar E, Axelrod-Ballin A, Shoshan Y, Wygoda M, Chisin R, Freedman N, Mishani E, Ziv I EARLY DETECTION OF RESPONSE OF BRAIN METASTASES TO RADIATION THERAPY BY 18F-ML-10, A NOVEL SMALL-MOLECULE PET TRACER FOR APOPTOSIS

28

15:15-15:30

Vaknin-Dembinsky A, Kassis I, Karageorgiou C, Gowda-Kurkalli B, Rachmilewitz J, Libster Y, Ben-Hur T, Slavin S, Karussis D IMMEDIATE BROAD SPECTRUM IMMUNOMODULATING EFFECTS INDUCED BY BONE MARROW DERIVED STEM CELLS (MSC), IN MULTIPLE SCLEROSIS PATIENTS TRANSPLANTED WITH MSC IN A PHASE I/II CLINICAL TRIAL

29

15:30-15:45

Israeli-Korn SD, Schwammenthal Y, Yonash-Kimchi T, Bakon M, Tsabari R, Orion D, Schwartz R, Bruk B, Merzeliak O, Chapman J, Tanne D A COMPARISON OF THE CHARACTERISTICS AND OUTCOME OF ACUTE BASILAR ARTERY OCCLUSION VERSUS ALL-CAUSE ISCHEMIC STROKE

30

15:45-16:00

Lavon I, Zelikovitch B, Refael M, Siegal T SERUM DNA CAN DEFINE TUMOR-SPECIFIC GENETIC EPIGENETIC MARKERS IN GLIOMAS OF VARIOUS GRADES

AND

-F-

POSTER SESSION Tuesday, January 7, 2009 Chair persons: Prof. Alex lossos Dr.Sergio Blumen

No 31

Ben Assayag E, Shopin L, Bova I, Gur A, Hallevi, Mike SA, Tsarfaty S, Korczyn A, Giladi N, Goldbourt U, Bornstein NM COGNITIVE IMPAIRMENT AFTER ACUTE ISCHEMIC STROKE: FIRST RESULTS FROM THE TABASCO STUDY

32

Shenhar-Tsarfaty S, Ben Assayag E, Berliner S, Ofek K, Soreq LT, Shopin L, Bova I, Shapira I, Soreq H, Bornstein NM THE VALUE OF CHOLINESTERASE MODULATIONS AS PREDICTORS OF NEUROLOGICAL OUTCOME AND SURVIVAL AFTER ACUTE ISCHEMIC STROKE

33

Raz N, Arkadir D, Levin N BEHAVIORAL AND CORTICAL ACTIVATION PATTERNS IN HEMIANOPIA

34

Hallevi H, Barreto AD, Morales MM, Grotta JC, Savitz SI THE IVH SCORE: A NOVEL TOOL FOR ESTIMATING INTRAVENTRICULAR HEMORRHAGE VOLUME: CLINICAL AND RESEARCH IMPLICATIONS

35

Nefussy B, Artamonov I, Deutsch V, Naparstek E, Nagler A, Drory VE RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ADMINISTRATION FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS: A PILOT STUDY

36

Andelman F, Kipervasser S, Maimon S, Neufeld M, Kramer U, Fried I COMPARATIVE STUDY OF THE WADA MEMORY TEST USING THREE DRUGS: AMOBARBITAL, BREVITAL AND ETOMIDATE

37

Eilam A, Loberboim M, Lampl Y, Gilad R POST STROKE SEIZURES AND BBB-DTPA SPECT STUDIES

38

Linetsky E, Lossos L, Levanon Y, Sharon N, Lossos A DIGITAL VOICE ANALYSIS IN PATIENTS WITH PARKINSON'S DISEASE (PD)

39

Tashlykov V, Schwartz R, Merzeliak O, Schwammenthal Y, Toashi M, Orion D, Tsabari R, Tanne D CEREBRAL ARTERY CALCIUM IN PATIENTS WITH ACUTE CEREBROVASCULAR DISEASES: DETERMINANTS AND LONG-TERM CLINICAL OUTCOME

40

Ifergane G, Shvartzman P TRIPTANS – IDENTIFYING BARRIERS FOR CONTINUOUS REGULAR USE

-G-

41

Dotan S, Raz N, Ben-Oliel T, Arkadir D, Vaknin A, Chokron S, Levin N VISUAL ATTRIBUTES FOLLOWING AN ACUTE OPTIC NEURITIS EPISODE – A LONGITUDINAL STUDY

42

Givaty G, Shechter– Amir D, Cohen O, Blatt I, Prohovnik, Chapman J EARLY PATHOLOGY IN SLEEP STUDIES OF PATIENTS WITH FAMILIAL CREUTZFELDT-JAKOB DISEASE

43

Horev A, Ifergane G, Wirguin I, Shelef I CEREBRAL VENOUS SINUSES DIAMETER VARIATION IN RESPONSE TO LUMBAR PUNCTURE IN IDIOPATHIC INTRACRANIAL HYPERTENSION

44

Ash EL, Gan-Or Z, Giladi N, Moore O, Orr-Urtreger A, Gurevich T CLINICAL CHARACTERISTICS OF PD PATIENTS CARRYING HOMOZYGOTIC AND COMPOUND HETEROZYGOTIC GBA MUTATIONS

45

Mosek A, Barkan R, Groppa S THE EFFICACY AND SAFETY OF MTR-106, A NON-SPECIFIC NOS INHIBITOR, IN THE TREATMENT OF ACUTE MIGRAINE WITHOUT AURA IN FEMALES: A RANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-ESCALATING STUDY

46

Orr-Urtreger A, Giladi N, Bar-Shira A, Kedmi M COMPREHENSIVE GENOME-WIDE APPROACH TO DETECT NOVEL TRANSCRIPTOMIC AND GENOMIC VARIATIONS IN PARKINSON’S DISEASE

47

Hellmann MA, Drory VE, Groozman GB, Melamed E, Djaldetti R LOWER LIMB REST TREMOR – A RED FLAG FOR THE DIAGNOSIS OF PARKINSON'S DISEASE

48

Appel SA, Schwartz R, Schwammenthal Y, Merzeliak O, Tsabari R, Orion D, Tanne D ALBUMIN-ADJUSTED CALCIUM CONCENTRATIONS MORTALITY IN PATIENTS WITH ACUTE STROKE

49

AND

LONG-TERM

Avisar A, Goldbourt U, Schwartz R, Tanne D ELEVATED LEVELS OF TC, LDL-C AND APO-B ARE ASSOCIATED WITH COGNITIVE IMPAIRMENT AMONG CHD PATIENTS

50

Cohen OS, Chapman J, Nitsan Z, Ephraty L, Tsabari R, Appel A, Korczyn AD, Kahana E, Prohovnik I CHARACTERIZATION OF MOVEMENT DISORDERS IN FAMILIAL CREUTZFELDJAKOB DISEASE (FCJD)

-H-

POSTER SESSION Wednesday, January 7, 2009

Chairpersons: Dr. Ron Dabby Dr. Adi Vaknin

No 51

Ephraty L, Meiner V, Cohen H, Hassin-Baer S IMPORTANCE OF EARLY DIAGNOSIS AND TREATMENT OF PATIENTS WITH CEREBROTENDINOUS XANTHOMATOSIS

52

Masarwa M, Israeli-Korn SD, Schechtman E, Abuful A, Strugatsky R, Avni SDS, Farrer LA, Friedland R, Inzelberg R HYPERTENSION INCREASES THE PROBABILITY OF ALZHEIMER'S DISEASE (AD) AND OF BEING COGNITIVELY IMPAIRED NOT DEMENTED (CIND) IN WADI ARA VILLAGES

53

Schlesinger I, Erikh I, Avizohar O, Sprecher E, Yarnitsky D CARDIOVASCULAR RISK FACTORS IN RESTLESS LEGS SYNDROME

54

Srygley JM, Mirelman A, Herman T, Giladi N, Hausdorff JM WHEN DOES WALKING ALTER THINKING? AGE AND TASK ASSOCIATED FINDINGS

55

Petrou P, Vaknin A, Karussis D THE IMPACT OF IN VITRO FERTILIZATION ON THE COURSE OF MULTIPLE SCLEROSIS

56

Albright KC, Hallevi H, Grotta JC, Savitz SI RECOVERY AFTER ISCHEMIC STROKE (RISE): CRITERIA FOR GOOD OUTCOME BY LEVEL OF DISABILITY AT DAY 7

57

Dorodnicov E, Shkil A, Milo R THROMBOLYSIS IN ACUTE ISCHEMIC STROKE: 3-YEAR EXPERIENCE AT THE BARZILAI MEDICAL CENTER

58

Giladi N, Mirelman A, Synhaeve N, Arets M, Levy S, Moore O, Simon E, Bar Shira A, Orr-Urtreger A, Gurevich T SEARCH FOR PRE-MOTOR SIGNS AND SYMPTOMS OF PARKINSON'S DISEASE IN FIRST DEGREE RELATIVES OF PD PATIENTS WHO ARE LRRK2 G2019S MUTATION CARRIERS. A PILOT STUDY

59

Meidan I, Mirelman A, Weiss A, Plotnik M, Inbar N, Giladi N, Hausdorff JM FREEZING OF GAIT IN PATIENTS WITH PARKINSON'S DISEASE: IS IT RELATED TO STRESS AND AUTONOMIC NERVOUS SYSTEM FUNCTION?

60

Aharon-Peretz J, Ibrahim R, Badarny S, Gamal H ESSENTIAL TREMOR PREVALENCE IS LOW IN DRUZE VILLAGES IN THE GALILEE: DOOR TO DOOR NEUROLOGICAL EXAMINATION

-INo 61

Arkadir D, Cohen J, Yitshaiek E, Gomori JM, Raphaeli G, Eichel R, Leker RR

62

Sabetay S, Mahagney A, Tov N, Masarwa S, Weller B

HEMICRANIECTOMY IMPROVES OUTCOME IN PATIENTS WITH FAILED ARTERIAL RECANALIZATION AFTER ACUTE CAROTID ARTERY OCCLUSION

CHANGES IN MIDDLE CEREBRAL ARTERY (MCA) FLOW BY USING CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) IN PATIENTS WITH SLEEP DISORDERED BREATHING (SDB)

63

Plotnik M, Bächlin M , Roggen D, Inbar N, Meidan I, Herman T, Brozgol M, Shaviv E, Tröster G, Hausdorff JM AUTOMATED TREATMENT OF FREEZING OF GAIT IN PARKINSON'S DISEASE USING A WEARABLE DEVICE THAT AUTOMATICALLY DETECTS FREEZING – PROOF OF CONCEPT

64

Newman JP, Linetzky E, Israel Z IS THERE ANY RELATIONSHIP BETWEEN END-STAGE PARKINSON’S DISEASE AND COGNITIVE OR MOOD DEFECTS?

65

Dagan K, Plotnik M, Gruendlinger L, Giladi N, Hausdorff JM EMOTION, COGNITION, FREEZING OF GAIT AND DUAL TASKING IN PATIENTS WITH ADVANCED PARKINSON'S DISEASE: A VOLATILE MIXTURE

66

Manor Y, Freud D, Giladi N, Mootanah R, Cohen JT “REPEATED FORCEFUL SWALLOW” FOR PARKINSON’S DISEASE PATIENTS WITH SWALLOWING DISTURBANCES

67

Levin N, Vaknin A, Chokron S, Ben-Hur T, Raz N FMRI AS A TOOL TO ASSESS CHIASMAL VISUAL DEFECT IN A PATIENT WITH NEUROMYELITIS OPTICA

68

Drory VE, Bronipolsky T, Bluvshtein V, Catz A, Korczyn AD OCCURRENCE OF FATIGUE MORE THAN 20 YEARS AFTER RECOVERY FROM GUILLAIN-BARRE SYNDROME

69

Keizman D, Ish-Shalom M, Berliner S, Maimon N, Vered Y, Artamonov I, Nefussy B, Drory VE LOW SERUM URIC ACID CONCENTRATION IN ALS. A LINK TO OXIDATIVE STRESS-RELATED MECHANISMS

70

Kahana E, Alter M, Zilber N, The Israeli MS study group MULTIPLE SCLEROSIS RISK IN MIGRANTS TO ISRAEL

-J-