THE heart center at nationwide children’s hospital

ISHAC

International Symposium on the Hybrid Approach to Congenital Heart Two DiseasePerspectives.

International Symposium on the Hybrid Approach to Congenital Heart Disease with live case presentations

Single Focus.

June 16–18, 2008 Hyatt Regency Columbus, Ohio Keynote Speakers Edward L. Bove, MD Head, Section of Cardiac Surgery Chief, Pediatric Cardiac Surgery University of Michigan Health System Ann Arbor, Michigan Terry D. King, MD, FAPP, FACC, FACCP Medical Director, Pediatric Surgery St. Francis Medical Center Monroe, Louisiana Clinical Professor of Pediatrics Tulane University School of Medicine

To learn more and to register for ISHAC, please visit www.hybridsymposium.com

Two Perspectives. Single Focus. Dear Friends and Colleagues: Please join us for the third International Symposium on the Hybrid Approach to Congenital Heart Disease (ISHAC) on June 16 – 18, 2008. We are honored to have keynote addresses from Edward L. Bove, MD, Head of the Section of Cardiac Surgery and Chief of Pediatric Cardiac Surgery at the University of Michigan Health System, and Terry D. King, MD, FAPP, FACC, FACCP, Medical Director of Pediatric Services at St. Francis Medical Center in Monroe, Louisiana, and Clinical Professor of Pediatrics at Tulane University School of Medicine. In this unique forum you will learn about the latest clinical and research developments from around the world. Indeed, the first two years, faculty and participants came from 33 states, 24 countries, and 5 continents. ISHAC has something for everyone – from tips on starting a hybrid program to follow-up studies on the postinterventional successes, challenges and complications. We are particularly pleased to continue the highly-valued Skills Workshop on June 16 at the University Laboratory Animal Resources Experimental Surgical Suites (ULAR). The outstanding staff at ULAR, coupled with the technically-skilled faculty and unique animal models, makes the Workshop an ISHAC favorite. In addition to podium presentations, seven live cases will be broadcast from Nationwide Children’s Hospital and ULAR (Columbus) and Rush University Medical Center (Chicago). You will actively participate by answering questions using the audience response system, thereby enabling you to know immediately what your colleagues are thinking! In order to foster even greater exchange of ideas, poster sessions have been added to the 2008 conference. Accepted poster presenters will receive a $100 refund on registration. For the abstract submission form, the latest updates on the conference, and/or to register online, please visit our web site at www.hybridsymposium.com. In addition, returning attendees will receive an additional $100 registration discount. So, don’t miss this offer! ISHAC will be held downtown at the Hyatt Regency Columbus, immediately adjacent to the Short North and Arena Districts – the fastest growing community in the Midwest. A cosmopolitan mix of night life and the arts, this community is just outside your hotel room. Social events include a welcome cocktail reception on June 16, and the Gala Barbecue Dinner at the The Party Barn on June 17. This casual event – where jeans and cowboy boots are welcome – will feature dinner, dancing, and free-flowing conversation. We extend our appreciation to the planning committee, ULAR staff, faculty, industry supporters, and everyone who has assisted with this year’s event.

John P. Cheatham, MD

Mark Galantowicz, MD

Co-Director, The Heart Center Director, Cardiac Catheterization & Interventional Therapy Nationwide Children’s Hospital Professor of Pediatrics and Internal Medicine, Cardiology The Ohio State University College of Medicine George H. Dunlap Endowed Chair in Interventional Cardiology

Co-Director, The Heart Center Chief, Cardiothoracic Surgery Nationwide Children’s Hospital Associate Professor of Surgery The Ohio State University College of Medicine Murray D. Lincoln Endowed Chair in Cardiothoracic Surgery

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

Industry Support Congenital heart disease (CHD) is a relatively common childhood disorder. While new transcatheter and surgical treatments have improved patient outcomes, many challenges remain. The Hybrid approach strives to further enhance clinical results by combining surgical and interventional management strategies, with the goal of diminishing the risks associated with the individual procedures. Additionally, it reduces the cumulative risks associated with multiple interventions. ISHAC showcases pioneering work of distinguished faculty who lecture, participate in panel discussions, and perform seven live case demonstrations from the Hybrid Suites at Nationwide Children’s Hospital and at Rush University Medical Center (Chicago), and University Laboratory Animal Resources Experimental Surgical Suites on the campus of The Ohio State University.

A very special thank you to our supporters.

Platinum

A unique aspect of ISHAC is the optional first day Skills Workshop which provides clinicians with hands-on experience using Hybrid procedures in animal models in a modern cardiovascular research facility. Separate registration is required for the Workshop.

Purpose ISHAC should enable participants to:

AGA Medical Corporation

1. Identify key factors in the design and funding of Hybrid Suites 2. Compare clinical outcomes between Hybrid and traditional approaches 3. Discuss future opportunities and challenges suggested by developments in basic science, translational, and biomedical engineering research

Toshiba Medical Systems

4. Discuss new surgical and interventional approaches for patients with complex CHD 5. Acquire clinical skills with new Hybrid treatments and devices (Skills Workshop only)

Poster Abstracts – New for 2008 In order to foster ongoing dialogue among highly respected colleagues from around the world, ISHAC will feature poster sessions during the Symposium (June 17 and 18). You are invited to submit an abstract on Hybrid therapy for congenital heart disease. The deadline for abstract submission is May 19, 2008. A $100 refund on the registration fee will be given to all accepted poster presenters. For more information about poster abstracts and to download the application, please visit the ISHAC web site at www.hybridsymposium.com.

Argon Beijing Zenomed Scientific Co. Ltd. Boston Scientific B Braun Cook Cordis Edwards Life Science ev3 HeartLab (Agfa) Maquet Medtronic Mobile Aspects, Inc. NuMED pfm AG Philips Scientific Software Solutions Stryker

2007 keynote speaker, Aldo Casteñeda, MD, (center) works with international participants during the Skills Workshop.

W.L. Gore

Symposium Host

THE heart center at nationwide children’s hospital

Program Directors: John P. Cheatham, MD and Mark Galantowicz, MD Workshop Directors: Ralf J. Holzer, MD and Alistair Phillips, MD Program Co-Director: Sharon L. Hill, MSN, ACNP-BC Program Coordinator: Karen E. Heiser, PhD

Qi-Ling Cao, MD Rush University Medical Center Chicago, IL Mario Carminati, MD San Donato Milanese Milan, Italy Jeffrey A. Feinstein, MD, MPH Stanford University Medical Center Stanford, CA Craig E. Fleishman, MD Arnold Palmer Hospital for Children Orlando, FL 2007 ISHAC Faculty

Ziyad M. Hijazi, MD Rush University Medical Center Chicago, IL

Faculty

Shengshou Hu, MD

Hakan Akintuerk, MD

Cardiovascular Institute & Fuwai Hospital

Universitatsklinikum Giessen

Beijing, China

Giessen, Germany

Frank F. Ing, MD

Zahid Amin, MD

Texas Children’s Hospital

Rush University Medical Center

Houston, TX

Chicago, IL

Terry D. King, MD

Renato Assad, MD

St. Francis Medical Center

Heart Institute University of Sao Paulo

Monroe, LA

Sao Paulo, Brazil

John P. Kovalchin, MD

Emile Bacha, MD

Nationwide Children’s Hospital

Children’s Hospital Boston

Columbus, OH

Boston, MA

Jinfen Liu, MD

John Bauer, PhD

Shanghai Children’s Medical Center

Nationwide Children’s Hospital

Pudong District, Shanghai, China

Columbus, OH

Pamela A. Lucchesi, PhD

Valerie Bergdall, DVM

Nationwide Children’s Hospital

University Laboratory Animal Resources

Columbus, OH

Columbus, OH

Achi Ludomirsky, MD

Philipp Bonhoeffer, MD

St. Louis Children’s Hospital

Great Ormond Street Hospital for Sick Children

St. Louis, MO

London, United Kingdom

Doff McElhinney, MD

Edward L. Bove, MD

Children’s Hospital Boston

C.S. Mott Children’s Hospital

Boston, MA

Ann Arbor, MI

Charles E. Mullins, MD

Redmond Burke, MD

Texas Children’s Hospital

Miami Children’s Hospital

Houston, TX

Miami, FL

page 3/4

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

Keynote Speakers Edward L. Bove, MD, is Vincent Olshove, CCP, CCT Nationwide Children’s Hospital Columbus, OH Carlos Pedra, MD Instituto Dante Pazzanese de Cardiologia Sao Paulo, Brazil Simone Fontes Pedra, MD Instituto Dante Pazzanese de Cardiologia Sao Paulo, Brazil Shakeel Qureshi, MD Evelina Children’s Hospital London, United Kingdom Daniel Rowland, MD

Honorable Guest Faculty Steve Allen, MD Chief Executive Officer Nationwide Children’s Hospital Jerry Jurgensen Chief Executive Officer Nationwide Insurance Company Abigail S. Wexner Chairman, Board of Trustees Nationwide Children’s Hospital

Organizing Committee

Nationwide Children’s Hospital

Robin Barr

Columbus, OH

Stephanie Cannon, MS

Dietmar Schranz, MD

Nicole Ferris

Universitatsklinikum Giessen Giessen, Germany Nikolay V. Vasilyev, MD

Jeanne Green Matthew Stiers, MBA

Children’s Hospital Boston

Donna Teach, MS

Boston, MA

Becky Williams, MEd

Professor in the Department of Surgery at the University of Michigan School of Medicine where he holds the Helen F. and Marvin M. Kirsch Professorship in Cardiac Surgery. He is also the Head, Section of Cardiac Surgery; Division Chief, Pediatric Cardiac Surgery Division; and Co-Director, Michigan Congenital Heart Center at the University of Michigan Health System in Ann Arbor, MI. After medical school at Albany Medical College, Dr. Bove pursued surgery and thoracic surgery training at the University of Michigan. He then joined the Hospital for Sick Children in London, England, as a Senior Registrar for additional training in complex congenital heart surgery. In addition to a very busy clinical practice, Dr. Bove serves on the American Board of Thoracic Surgery and the Editorial Board of The Journal of Thoracic and Cardiovascular Surgery. Dr. Bove is considered one of the world’s outstanding pediatric cardiac surgeons and is particularly renowned for his work with hypoplastic left heart syndrome. Indeed, over 40 percent of his patients come from outside Michigan, including many countries around the world. Dr. Bove is listed in Who’s Who in Health and Medical Services and the Best Doctors in America.

Gil Wernovsky, MD

Terry D. King, MD,

Children’s Hospital of Philadelphia

a world renowned pediatric interventional cardiologist from Monroe, LA, has had a most extraordinary career. Dr. King graduated medical school and completed his internship in Pediatrics at the University of Texas Branch in Galveston, and his residency and fellowship in Pediatric Cardiology at Duke University. After serving as a major in the US Air Force, Dr. King joined the staff at the Ochsner Clinic where he became chairman of the department in 1973. It was there he met Dr. Noel Mills, a cardiac surgeon, and together they pursued a vision for non-invasive closure of defects in the heart. Working with a machinist from Baton Rouge, Dr. King and Dr. Mills developed and patented the cardiac umbrella for nonsurgical closure of ASD’s and, subsequently, a device for PDA closure. In 1975, Dr. King became the first person to implant and close an ASD in a human being. After receiving many awards and traveling the globe to give talks on this new technology, Dr. King decided to leave Ochnser and move to the rolling hills of West Monroe, LA. He established the NICU, PICU, cardiac cath lab, and congenital cardiac disease program at St. Francis Medical Center and, along the way, he also co-founded the Ronald McDonald House in Monroe. Most recently, Dr. King was honored to receive the first Pioneer Award presented by the Pediatric Interventional Cardiac Symposium in Las Vegas and the first annual Terry King Lectureship in Pediatric Cardiology established by Louisiana State University and Children’s Hospital, New Orleans.

Philadelphia, PA Loren Wold, PhD Nationwide Children’s Hospital Columbus, OH Zhen Xu, PhD University of Michigan Ann Arbor, MI

Left to right: John P. Cheatham, MD, Aldo R. Casteñeda, MD, PhD, Mark Galantowicz, MD and Michael J. Tynan, MD — 2007 Keynote speakers and program directors

Program

THE heart center at nationwide children’s hospital

Sunday, June 15, 2008 7:00 pm

Workshop Cocktail Reception at Hyatt Regency Registration Available

Monday, June 16, 2008, Skills Workshop Directors: Ralf J. Holzer, MD, Alistair Phillips, MD, and Valerie Bergdall, DVM

7:15 am

7:30 – 8:00 am

Continental Breakfast Welcome & Overview of Stations

Ralf J. Holzer, MD Alistair Phillips, MD

8:00 am – Noon

SKILLS STATIONS

FACULTY

or

I. Perventricular VSD Closure

1:00 – 5:00 pm





II. Intraoperative Stents



III. Hybrid Stage I HLHS Palliation ➜ PA Bands ➜ PDA Stent ➜ PA Flow Restrictors



IV. Special Break-out Sessions and Demonstrations



11:30 am

Buses take Group 2 to Workshop



Noon



1:00 pm

Buses return Group 1 to Hyatt Regency



5:00 pm

Buses return Group 2 to Hyatt Regency



6:00 – 8:00 pm

Hybrid teams at ULAR during perventricular device closure of MVSD using epicardial echo guidance.

page 5/6

Buses take Group 1 to Workshop

Lunch Provided for Groups 1 & 2

Welcome Cocktail Reception at Hyatt Regency Registration Available

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

Program

Tuesday, June 17, 2008 Symposium, Day One

7:00 – 7:45 am

Continental Breakfast & Registration with Posters & Displays

7:45 – 8:00 am Welcome

Steve Allen, MD Jerry Jurgensen

Introductory Remarks

John P. Cheatham, MD Mark Galantowicz, MD

8:00 – 10:15 am Hypoplastic

Moderators: Ziyad M. Hijazi, MD Jinfen Liu, MD Gil Wernovsky, MD



8:00 – 9:15 am

Left Heart Syndrome Part I

Hybrid Experiences from Abroad



-C  ardiovascular Institute & Fuwai Hospital Beijing, China

Shengshou Hu, MD



- I nstituto Dante Pazzanese de Cardiologia Sao Paulo, Brazil

Carlos Pedra, MD



-E  velina Children’s Hospital London, United Kingdom

Shakeel Qureshi, MD



-U  niversitatsklinikum Giessen: Hybrid Approach for HLHS…an update Giessen, Germany

Dietmar Schranz, MD



LIVE CASE: Hybrid HLHS Nationwide Children’s Hospital Hybrid Catheterization/OR Suites

John P. Cheatham, MD Mark Galantowicz, MD Sharon L. Hill, MSN, ACNP

10:15 – 10:30 am

Break with Posters, Displays, & Discussion

9:15 – 10:15 am

10:30 – 12:00 pm Hypoplastic

Left Heart Syndrome Part II

Moderators: Zahid Amin, MD Emile Bacha, MD Carlos Pedro, MD

10:30 – 11:30 am

- Traditional PA Bands

Hakan Akintuerk, MD



- Adjustable PA Bands

Renato Assad, MD



- Pulmonary Artery Flow Restrictors Alistair Phillips, MD from ULAR

11:30 – 12:00 pm

LIVE CASE: Pulmonary Artery Flow Restrictors University Laboratory Animal Resources (ULAR) Experimental Surgical Suites

Alistair Phillips, MD Ralf J. Holzer, MD

I thought that last year’s meeting was excellent. Probably the most important aspect for most of the delegates was the way the Columbus faculty demonstrated the truly collaborative nature of the Hybrid program. They achieved this in both their didactic role and in their personal contacts with visitors. Their open, inclusive and friendly approach was a great educational experience. The day in the Workshop was outstanding. I am sure that, after that experience, many returned to their own units fired up with enthusiasm to put what they had learned into clinical practice. Finally, it was a lot of fun.

Michael J. Tynan, MD Jeffrey A. Feinstein, MD, MPH, is the audience response moderator at Live Cases.

Program

THE heart center at nationwide children’s hospital

Tuesday, June 17, 2008 Symposium, Day One 12:00 – 1:00 pm

Lunch with Posters, Displays, & Discussion

1:00 – 2:15 pm Hypoplastic

Moderators: Hakan Akintuerk, MD Sharon L. Hill, MSN, ACNP-BC John P. Kovalchin, MD Shakeel Qureshi, MD

1:00 – 2:15 pm

- HLHS with IAS: Fetal Therapy

Doff McElhinney, MD



- Histotripsy & the Atrial Septum

Achi Ludomirsky, MD



- The Atrial Septum . . . The Achilles Heel?

John P. Cheatham, MD



- Retrograde Aortic Arch Obstruction…Uh Oh!

Ziyad M. Hijazi, MD

2:15 – 2:30 pm

Break with Posters, Displays, & Discussion

2:30 – 4:00 pm Hypoplastic 2:30 – 3:15 pm



Left Heart Syndrome Part III

Left Heart Syndrome Part IV

LIVE CASE: Histotripsy of the Atrial Septum ULAR Experimental Surgical Suites

Moderators: Redmond Burke, MD Craig E. Fleishman, MD Simone Fontes Pedra, MD Achi Ludomirsky, MD Zhen Xu, PhD

3:15 – 4:00 pm

Advances in the Treatment of HLHS



- Rethinking the Surgical Approach to HLHS



- Hybrid Approach to HLHS: How Are We Doing? Mark Galantowicz, MD



Laissez les bon temps rouler! The Early Years—New Orleans, LA

4:00 –5:00 pm

keynote The Surgeon, Innovation, speakers



Emile Bacha, MD

Terry D. King, MD Edward L. Bove, MD

and Accountability in Today’s Medical Environment

5:00 – 5:15 pm

Wrap Up



5:30 pm Buses leave for Tour of Nationwide Children’s Hospital Hybrid Catheterization/OR Suites



6:30 pm



6:30 pm Buses leave Nationwide Children’s Hospital for Gala Barbecue Dinner at The Party Barn

7:00 – 11:00 pm

page 7/8

11:00 pm

John P. Cheatham, MD Mark Galantowicz, MD

Buses leave hotel for Gala Barbecue Dinner at The Party Barn

Gala Barbecue Dinner with entertainment and dancing (Casual dress—jeans and cowboy boots welcome) Buses return to Hyatt Regency

Jeffrey A. Feinstein, MD, MPH, is the audience response moderator at Live Cases.

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16-18, ‘08

Program

Wednesday, June 18, 2008 Symposium, Day Two 7:00 – 7:45 am

Continental Breakfast Posters & Displays

John P. Cheatham, MD Mark Galantowicz, MD



7:45 – 8:00 am

Update & Announcements



8:00 – 8:30 am

Starting a Hybrid Program



-F  inding the Resources: Securing Financial & Community Support

Abigail S. Wexner



- Design of Hybrid Catheterization & OR Suites

Vincent Olshove, CCP, CCT

8:30 – 9:45 am SEPTAL DEFECTS Part I

8:30 – 9:45 am

Moderators: Renato Assad, MD Jinfen Liu, MD Dietmar Schranz, MD

- Challenges of Surgical Closure of MVSD

Edward L. Bove, MD



-C  hallenges of Percutaneous Device Closure of MVSD

Mario Carminati, MD



- Perventricular Device Closure of MVSD

Zahid Amin, MD



- Peratrial Device Closure of Secundum ASD

Carlos Pedra, MD

9:45 –10:00 am

Break with Posters, Displays, & Discussion

10:00 – 11:15 am HYBRID

APPROACH TO STENTS

Moderators: Mark Galantowicz, MD Shengshou Hu, MD Charles E. Mullins, MD

10:00 – 11:15 am

- Challenges of Re-operation for Pulmonary Artery Stenosis & Recoarctation of Aorta… And Stents to Boot!!!

Redmond Burke, MD



- Intraoperative PA Stents

Ralf J. Holzer, MD



- Intraoperative Aortic Stents

Redmond Burke, MD



- Intraoperative VSD Stents & More

Frank F. Ing, MD

11:15 – 12:15 pm

LIVE CASE: Intra-operative PA Stent Nationwide Children’s Hospital Hybrid Catheterization/OR Suites

Ralf J. Holzer, MD Alistair Phillips, MD Vincent Olshove, CCP, CCT

12:15 – 1:15 pm

Lunch with Posters, Displays, & Discussion First Fung Wexner Awards Announced

1:15 – 3:15 pm SEPTAL DEFECTS Part II

Moderators: Mario Carminati, MD Charles E. Mullins, MD Simone Fontes Pedra, MD

1:15 – 2:00 pm

Ziyad M. Hijazi, MD Qi-Ling Cao, MD Michel N. Ilbawi, MD

LIVE CASE: Perventricular Muscular VSD Device Closure Rush University Medical Center, Chicago

Jeffrey A. Feinstein, MD, MPH, is the audience response moderator at Live Cases.

Program

THE heart center at nationwide children’s hospital

Faculty and participants from 25 states, 17 countries and 5 continents attended lectures during Symposium.

Wednesday, June 18, 2008 Symposium Day Two 2:00 – 2:45 pm

- Creation & Closure of Septal Defects Using Real Time 3D Echo Guidance

Nikolay V. Vasilyev, MD from ULAR



- Advanced Imaging of the Septum

Craig E. Fleishman, MD

- Advanced Imaging for Interventional Procedures

Philipp Bonhoeffer, MD

2:45 – 3:15 pm LIVE CASE: Closure of Septal Defect Using Real Time 3D Echo Guidance ULAR Experimental Surgical Suites

Nikolay V. Vasilyev, MD Achi Ludomirsky, MD

3:15 – 3:30 pm

Break with Posters, Displays, & Discussion

3:30 – 5:00 pm THE

FUTURE

Moderators: Philipp Bonhoeffer, MD Terry D. King, MD Pamela A. Lucchesi, PhD Zhen Xu, PhD

3:30 – 5:00 pm

- New Developments in Implanting the Melody Pulmonary Valve...The Infundibular Reducer

Philipp Bonhoeffer, MD



-N  eurodevelopmental Outcomes in Congenital Heart Disease

Gil Wernovsky, MD



- Bioabsorbable Stents…A Savior for All?

Dietmar Schranz, MD

- Inflammatory Mechanisms in Congenital Heart Disease

-M  yocardial & Progenitor Cell Function in Congenital Heart Disease

5:00 – 5:15 pm Closing Remarks

7:00 pm

Loren Wold, PhD John P. Cheatham, MD Mark Galantowicz, MD

Informal Dinner at Hyatt Regency

ISHAC has granted us knowledge and opportunities to grow. Much of our learning came from you and ISHAC 2006 and 2007, and we are very grateful for everything you have taught us during those meetings.

Renato and I have been working closely and the outcome of Hybrid Stage I for HLHS has improved. Additionally, we have performed perventricular MVSD device closure with good results. As for fetal interventions, we did four cases so far, two atrial septostomies, one aortic valvuloplasty and one pulmonary valvuloplasty.

Sincerely,

Best,

Renato Assad, MD

page 9/10

John Bauer, PhD

Carlos Pedra, MD

Jeffrey A. Feinstein, MD, MPH, is the audience response moderator at Live Cases.

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

2007 ISHAC Highlights

Live Cases

Workshop Session

Live Cases

Lecture from ULAR

Pioneers in congenital heart diseaseAldo Castañeda, MD, PhD, (l) and Kurt Amplatz, MD (r)

Workshop Session

Workshop Session

ISHAC. Let me say straight up, I love this meeting. It’s the most fun and the most I learn at any meeting during the year. Regards,

Evan Zahn, MD Gala Dinner

Evan Zahn, MD (r)

Symposium Events/Columbus

Symposium Events

Coming to Columbus

Monday, June 16, 2008 6:00 – 8:00 PM Welcome Cocktail Reception Please join us for cocktails, wine, cheese and friendship at the Hyatt Regency in downtown Columbus. A great way to kick-off ISHAC 2008!

Columbus offers no shortage of activities for ISHAC’s 2008 participants and their guests. In addition to serving as Ohio’s capital, Columbus is also the nation’s fifteenth largest city, with a dynamic business climate, a commitment to diversity, exciting annual festivals and cultural events, unique arts and entertainment opportunities, and home to great professional, collegiate and amateur sports. Downtown Columbus is alive with a wide array of shopping and dining experiences. The Hyatt Regency, our conference hotel, sits at the gateway to Columbus’ Short North and Arena districts overflowing with galleries, boutique shopping and great late-night dining and entertainment opportunities. Downtown is flanked to the south by German Village. A walk through this brick-paved shopping and dining district is reminiscent of old-world Europe.

Tuesday, June 17, 2008 7:00 – 11:00 PM Gala Barbecue Dinner The Party Barn – Casual Attire (Jeans and Cowboy Boots Welcome) Get ready to kick-up your heels for ISHAC’S Gala Barbecue Dinner at The Party Barn located on the private Wexner estate in New Albany, Ohio. The centerpiece of this exclusive venue is a 10,000 square-foot traditional barn constructed entirely of yellow pine and featuring a unique beam and peg constructed interior. On arrival, guests will be welcomed with cocktails and a gourmet American Barbecue with all the fixings. Attire for the evening is casual with jeans and cowboy boots welcome. After-dinner events will take place inside the barn and outside under the stars with dancing and other special surprises. Our appreciation to the Wexner family for offering this wonderful location for our Gala celebration. Wednesday, June 18, 2008 7:00 PM Informal Dinner at the Hyatt Regency Remaining ISHAC faculty and participants are invited to join us for an informal dinner.

Downtown Columbus

page 11/12

THE heart center at nationwide children’s hospital

Get ready to kick up your heels at the Gala Barbecue Dinner

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

Columbus

Airport Port Columbus International Airport, located just 15 minutes from the Hyatt Regency, is served by 10 airlines and their regional affiliates providing more than 340 daily arrivals and departures to 36 airports. Carriers include Air Canada Jazz, American, Continental, Delta, Northwest, Southwest, SkyBus, United, USA 3000 and US Airways. All ground transportation may be accessed via the terminal walkway or baggage claim level exits. Taxi service is provided by many vendors. The average fare from Port Columbus International Airport to the Hyatt Regency is $20-22. Airport shuttles are available by several carriers with walk-up service, and run every 20 minutes to downtown Columbus. Cost varies based on the number of passengers.

Accommodations A room block has been reserved for registrants of ISHAC at the Hyatt Regency. The Hyatt Regency is ideally located in downtown Columbus, central to shopping, dining and entertainment. The hotel is five minutes from The Ohio State University. Hyatt Regency is newly renovated among downtown Columbus hotels. City or campus views are available. All rooms have wireless internet service, and the hotel features an indoor pool and fitness center.

Please contact the hotel directly for lodging registration and mention you are attending the ISHAC Symposium. Please secure your hotel room as soon as possible. Information for the Hyatt Regency and other recommended hotels in the area include: Hyatt Regency Columbus (Host Hotel) Located in downtown Columbus 350 North High Street Columbus, Ohio USA 43215 www.columbusregency.hyatt.com Toll Free: 1 (888) 591-1234 (Group Rate Code: ISHAC) Drury Inns & Suites – Columbus Convention Center Located in downtown Columbus 88 East Nationwide Blvd. Columbus, Ohio 43215 www.druryhotels.com Toll-Free: 1 (800) DRURYINN (Group Rate Code: Nationwide Children’s Hospital) Hampton Inn & Suites Located in downtown Columbus 501 North High Street Columbus Ohio 43215 http://hamptoninn.hilton.com Toll Free: 1 (800) HAMPTON (Group Rate Code: Children’s Hospital) If you have any difficulty securing a reservation, please contact Matt Stiers at (614) 355-0675 or [email protected]

The Short North’s Gallery Hop

Conference Information

Symposium/Skills Workshop Pricing Information Please Note: The optional Workshop is only available for Symposium attendees. Space in the Workshop is limited. Registration will be confirmed within two weeks of receipt of payment. The ISHAC Planning Committee reserves the right to limit registration to assure a quality educational experience.

Registration Fees (in US Dollars)

Past Participant Rate*

Symposium Registration – MD**

$700.00

$600.00

Symposium Registration – trainees and non-MD**

$550.00

$450.00

Welcome Reception, June 16 (non-registered guests)

$50.00

$50.00

Gala Barbecue Dinner, June 17 (non-registered guests) Optional – Skills Workshop*** Open only to Symposium registrants (Space is limited)

$100.00 $400.00

$100.00 $400.00

* Past ISHAC participants (2006 and/or 2007) may register at the discounted rate. ** Symposium registration includes attendance at the two-day Symposium, the welcome reception, educational materials, continental breakfasts, lunches, Gala dinner and ISHAC scrub hat. *** Continental breakfast and lunch are included. A $100 refund on registration fees will be given to all accepted poster presenters.

How to Register

Continuing Education

Attendees may register online at www.hybridsymposium.com or by using the attached registration form. Please follow the instructions carefully. A credit card must be used to register online. Upon receipt of the registration fee for ISHAC, each attendee will receive a registration confirmation within two weeks. The registration fee includes the educational material, breakfast, lunch, welcome reception, and Gala Barbecue Dinner.

Nationwide Children’s Hospital is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Cancellation Policy A refund, minus 30% for administrative costs, will be given for cancellation received in writing before June 6, 2008. After this date, no refund will be possible. For a change of name, a fee of $50.00 will be charged. Full refund of the Workshop registration fee will be given to those who cannot be accommodated in the Workshop.

Concert in Battelle Plaza in the Arena District. Photo courtesy of Nationwide Realty Investors

page 13/14

Nationwide Children’s Hospital designates this educational activity for a maximum of 19.0 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

INTERNATIONAL SYMPOSIUM ON THE HYBRID APPROACH TO CONGENITAL HEART DISEASE (ISHAC) • JUNE 16–18, ‘08

Registration Form

For your convenience, register online at www.hybridsymposium.com Prefix  Ms.  Mrs.  Mr.  Dr.

Name

Degree

Preferred name for badge Title

Organization

Address City

State

Zip

Country

Work County (if Ohio resident) Telephone (work)

(home)

Fax

E-mail Address

Guest Name

 I prefer a vegetarian lunch. Specialty

 Surgeon  Interventionalist  Cardiologist  Other (please explain) ______________________________________________________________________ Special Services Required  Sign language for the hearing impaired  Wheelchair seating  Other (please explain) ______________________________________________________________________ Hybrid Cardiac Catheterization and Surgical Suites Tour

 I am interested in touring the Hybrid Suite at Nationwide Children’s Hospital during ISHAC. Registration Fees (in US Dollars) Past Participant Rate* Symposium Registration – MD** $700.00 $600.00 Symposium Registration – t rainees and $550.00 $450.00 non-MD** Welcome Reception, June 16 $50.00 $50.00 (non-registered guests) Gala Barbecue Dinner, June 17 $100.00 $100.00 (non-registered guests) Optional – Skills Workshop*** $400.00 $400.00 Open only to Symposium registrants (Space is limited) Total

Subtotal $

$ $ $ $

* Past ISHAC participants (2006 and/or 2007) may register at the discounted rate. ** S ymposium registration includes attendance at the two-day Symposium, the welcome reception, educational materials, continental breakfasts, lunches, Gala dinner and ISHAC scrub hat. *** Continental breakfast and lunch are included. A $100 refund on registration fees will be given to all accepted poster presenters.

Social Events (Events included with full conference registration. Please check the events you plan to attend.)  Welcome Reception  Gala Dinner  Wednesday Informal Dinner Amount Enclosed: $__________________ Payment:  Cash  Check

Credit Card Information:  Visa  MasterCard

Card #

Exp. Date

Name on Card Please make check payable to nationwide CHILDREN’S HOSPITAL and mail with registration form to: ISHAC Conference Coordinator, Education Department, Nationwide Children’s Hospital, PO Box 7199, Columbus, OH 43205-7696, FAX (614) 355-0670 If registering multiple individuals, please duplicate this form. ADA – We encourage participation by all individuals. If you have a disability, advance notification of any special needs will help us serve you better. Please notify us of your special needs at least two weeks in advance. Questions? – Contact the Professional Conference Coordinator, Nationwide Children’s Hospital, Education Department, P.O. Box 7199, Columbus, Ohio, USA, 43205-0199, (614) 355-0675 or see our web site at www.hybridsymposium.com.

Platinum Supporters • AGA Medical Corporation 700 Children’s Drive Columbus, Ohio 43205 (614) 355-0675 In Educational Partnership with:

International Symposium on the Hybrid Approach to Congenital Heart Disease (ISHAC) Register online at

www.hybridsymposium.com

• Toshiba Medical Systems