FINAL PROGRAM

October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Index

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Welcome Message . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Organizing Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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List of Speakers, Chairs & Tutors Scientific Program

General Information

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Acknowledgements

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Welcome Message «stay small but perform with distinction» 4  European Combo-Endocrinology Course on 6th-8th  October 2016 in Athens, Greece, on ‘Ageing and Anti-Ageing Endocrinology’ th

A Comprehensive Course to guide how to improve the quality of your practice for you and your patients. This is the fourth year of the new series of “COMBO – ENDOCRINOLOGY” comprehensive, annual course. The main goal of these course series is to provide trainees, fellows, early career professionals with a complete, in-depth knowledge on  specific hot topics of Endocrinology in a combined (Combo) approach with other medical/surgical specialties. COMBO ENDOCRINOLOGY meetings will be monothematic courses providing knowledge on a different endocrine entity each year, through lectures, meet-the-expert sessions and case presentations. This year’s theme will be on Ageing and Anti-Ageing Endocrinology. This course is designed as an educational tool and a practical manual to understand the impact of ageing on various endocrine-related entities such as metabolism, skin, reproductive system, thyroid, bones, psychological and nutritional aspects, hormonal changes etc. as well as how to approach the ageing male and female in terms of management and ‘anti-ageing’ techniques. Highlights of this course are the workshops where participants under the guidance of their tutor in a particularly interactive way, are encouraged to step forward, present innovative ideas on ageing and anti-ageing projects and case presentations, learn about how hormones and bioactive products affect ageing and broaden the horizons of the conventional endocrinology approach. This is an innovative idea, started three years ago and found fertilizing ground among different specilities linked with endocrinology and inspired colleagues. This year is organized by Athens Euroclinic, Greece and Dessau Medical Centre, Germany, aiming to bring together scientists from different specialty backgrounds to target a specific endocrine topic and promote the attractive multidimensional profile of Endocrinology. It is our pleasure to see this effort being embraced with great interest by a growing number of young scientists. Consequently, a debt of gratitude is owed to each one of the distinguished tutors and speakers, who are embarking on their scientific topics and are serving our ultimate targets, education and clinical practice! Therefore, from heart thanks to their synergistic confluence that has given birth to this unique interactive course with my true appreciation to our financial supporters who have helped it to make steady steps forward. Undoubtedly, my high esteem is owed to each member of the organizing committee and especially this year to my vice president, Professor Christos Zouboulis, who has provided tirelessly input on every step of the efforts to achieve and maintain high scientific standards of the course. Thus, we have arrived at 4th COMBO ENDO with pride and with greater degree of responsibility to every participant, whose presence in this course consolidates our commitment and dedication to teach and practice evidence based medicine! Yours, Evanthia Diamanti-Kandarakis MD, PhD Professor of Internal Medicine, Endocrinology & Metabolism Head of Department of Endocrinology and Diabetes Center of Excellence, Athens Euroclinic, Greece  President of the Course

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Organizing Committee President Evanthia Diamanti Kandarakis

Vice President of the course Christos Zouboulis

Board Members Djuro Macut Renato Pasquali Shahla Nader-Eftekhari Marija Pfiffer Huhtaniemi Ilpo Mastorakos George Duntas Leonidas Goulis G. Dimitrios

Kassi Georgia Michalaki Marina Peppa Melpomeni Vrionidou Andromachi Tzanella Marinella Pantazi Eleni Vlassopoulou Barbara Ζ. Μusleh

Ι.-Α. Vatalas S. Livadas V. Vasiliou Ν. Agelopoulos Α. Thomopoulos G. Kassi

Course Organizer FREI S.A. Travel - Congress 3 Paparrigopoulou Street, 105 61 Athens, Greece Tel: +30 210 3215600, Fax: +30 210 3219296 E-mail: [email protected], [email protected] • Web: www.frei.gr

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

List of Speakers, Chairs & Tutors Alexandrides Theodore Professor of Internal Medicine-Endocrinology Division of Endocrinology, University of Patras Androulakis Ioannis MD,PhD Endocrinologist Dep of Endocrinology Georgios Genimatas General Hospital Athens Bargiota Alexandra Assistant Professor in Internal medicine-Endocrinology, University of Thessaly Head of the Department of Endocrinology and Metabolic diseases, University Hospital of Larissa, Greece Damjanovic Svetozar Professor of Internal Medicine, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Medical School, University of Belgrade, Serbia Maurizio Datillo CEO Partenogen CO0, Lugano Swiss Dimosthenopoulos Charilaos MMedSci.PhDc Clinical Dietitian-Biologist Chief Dietitian of the Department of Clinical Nutrition at Laiko Hospital, Athens, Greece Duntas Leonidas Professor of Internal Medicine and Endocrinology, Medical School, University of Ulm, Germany; Clinical and Research Associate, Endocrine Clinic, Evgenidion Hospital, University of Athens, Greece

Gonos Efstathios Director of Research; IUBMB Executive Committee Member for Congresses and Conferences, National Hellenic Research Foundation Institute of Biology, Medicinal Chemistry and Biotechnology Goulis G. Dimitrios Associate Professor in Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, First Department of Obstetrics & Gynecology, Greece Huhtaniemi Ilpo MD, PhD, FMedSci Professor Emeritus of Reproductive Endocrinology, Institute of Reproductive and Developmental Biology, Department of Surgery & Cancer Imperial College London, UK Kanaka Gantenbein Christina Professor of Pediatric Endocrinology, First Department of Pediatrics Medical School, National and Kapodistrian University of Athens - Greece «Aghia Sophia» Children’s Hospital Kassi Georgia Endocrinologist, Director, University Unit of Endocrinology, 3rd Department of Medicine,Sotiria General Hospital, Athens School of Medicine,National & Kapodistrian University,Greece

Koukkou Eftychia Doctor, Endocrinologist, Chief of Endocrine Dept.at ELENA VENIZELOU Hospital Lambrinoudaki Irene Associate Professor of Gynecological Endocrinology, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital,Athens, Greece; President EMAS: European Menopause and Andropause Society Djuro Macut MD, PhD Associated Professor of Internal Medicine and Endocrinology Clinic for Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Serbia Makrilakis Konstantinos MD, MPH, PhD Associate Professor in Internal Medicine, National and Kapodistrian University of Athens Medical School, Laiko General Hospital, Athens, Greece Mastorakos George MD, DSc; Professor of Endocrinology; School of Medicine; National and Kapodistrian University of Athens, Greece Michalaki Marina Senior Registrar in Endocrinology, Endocrine division, Internal Medicine Department, University Hospital of Patras, Greece

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

List of Speakers, Chairs & Tutors Migdalis Ilias MD, PhD, Director, 2nd Medical Department & Diabetes Centre, NIMTS Hospital, Athens, Greece Mouslech Zadalla Dr, Endocrinologist, President of the executive board of Hellenic Endocrine SocietyPanhellenic Association of Endocrinologists Nader- Eftekhari Shahla Professor, Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, Mc Goven Medical School, The University of Texas, USA Pantazi Eleni Endocrinologist Head of Department of Endocrinology Alexandra's Hospital Athens, Greece Pasquali Renato ​Full professor of Endocrinology and Metabolism, Director of the Unit of Endocrinology, S. Orsola-Malpighi Hospital of Bologna, Italy

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Peppa Melpomeni Associate Professor in Endocrinology, National and Kapodistrian University of Athens, Second Dept of Internal Medicine, Propaedeutic Research Institute and Diabetes Center Attikon University Hospital, Athens, Greece Pfeifer Marija Professor of Internal Medicine and Endocrinology at the Medical faculty, University of Ljubljana, Slovenia, and Head of the Department of Endocrinology at the University Medical Centre Ljubljana, Slovenia Polymeris Antonios Senior Consultant Endcrinologist Department of Endocrinology Alexandras Hospital, Athens Greece Tentolouris Nikolaos Associate Professor, Medical School, National & Kapodistrian University of Athens, 1st Department of Propaedeutic & Internal Medicine, Laiko General Hospital, Athens, Greece Tzanella Marinella Endocrinologist, Evangelismos Hospital, Athens, Greece

Vassilatou Evangeline Dr. Endocrinologist Director, Endocrine Unit 2nd Department of Internal Medicine «ΑΤΤΙΚΟΝ» University Hospital, Athens Greece Vlahos Nikolaos Professor of Obstetrics and Gynecology and Reproductive Medicine, University of Athens School of Medicine, Athens Greece  Vrionidou Andromachi MD, PhD, Director of Department of Endocrinology & Metabolism Korgialenio-Benakio Hospital, Athens, Greece Vlassopoulou Barbara MD, PhD Consultant Endocrinologist Department of Endocrinology, Diabetes & Metabolism Evangelismos Hospital, Anthes, Greece Zouboulis Christos Prof. Dr. Prof. h.c. Dr. h.c. Director, Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Scientific Program Thursday 06 October 2016 13.00-15.00

Registrations





Room A

15:00-16:30 Get Together Workshop A Νovel Insulins & The Microbiome Chairs:

• •

Zadalla Mouslech, Georgia Kassi

Nikolaos Tentolouris Biosimilar and new mixture of Insulins Christina Kanaka-Gantenbein Altering the microbiome to treat Diabetes

16:30-17:30 Welcome to the 4th COMBO: Introduction to COMBO attitude IN ENDOCRINOLOGY E.D K Early Detection/Prevention of Aging Disorders

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•

Session I

 The network and the remodeling theories of ageing: historical background and new perspectives Evanthia Diamanti-Kandarakis  The Endocrinology of Ageing: Controversial endocrine intervention for the aged Christos Zouboulis

Participants introduce themselves 17:30-21:30

Τhe need for anti-ageing medicine



Workshop 1

Teaching using case scenarios and consultation techniques - Interactive Program Cases: Diagnosis & Prescription (Groups: G1,G2,G3,G4)

17:30-18:50 All Groups together (G1,G2,G3,G4) Chairs: George Mastorakos, Renato Pasqualli Ilpo Huhtanemi

20 min Introductory tutorial per tutor/topic G1: Testosterone Treatment, Monitoring: who, why, and when! Irene Lamprinoudaki G2: Benefits And Risks Of HRT: who, why, and when! Djuro Macut G3: Growth Hormone treatment options and the ageing Patient: who, why, and when Marija Pfeifer G4: Antiosteoporotic treatment for the aging male: who, why, and when

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

18:50-20:20 Each tutor with his/her Group (G1,G2,G3,G4) PREPARATION Case discussion/Preparation for presentation by participants Group 1

Case Preparation for presentation by the participants

Room A1

Group 2

Case Preparation for presentation by the participants

Room A2

Group 3

Case Preparation for presentation by the participants

Room B

Group 4

Case Preparation for presentation by the participants

Room C

20:20-21:20 All Groups together (G1,G2,G3,G4). Case Presentations Case Presentation by Participants (15 min/case) and discussion

21:30-23.00

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Dinner for the participants

Room A

October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Friday, 07 October 2016 06:30-08:00 Breakfast

Room A



08:30-10:00 Get Together How to avoid Insulin dosing errors

Workshop B

Chairs: Theodoros Alexadridis, Ilias Migdalis Evangeline Vassilatou Eftychia Koukkou 10:00-11:30

Variability of insulin absorptions Dark side of insulin therapy: Insulin dosing errors

Ageing with Diabetes

Session II

Chairs: Marina Michalaki, Eriffili Hatziagelaki Efstathios Gonos Personalized anti-ageing diagnosis and Treatment Theodoros Alexandridis Type 2 Diabetes and the Ageing Pancreatic Beta Cell Maurizio Dattilo Oxy-redox regulation of Insulin resistance, ageing and the effect of diet: opportunities to improve the metabolic homeostasis 11:30 -12:00

4th COMBO Photo and Coffee Break

12:00-13:30

Treat the ageing Diabetic

Session III

Chairs: Eleni Pantazi, Andromachi Vrionidou T reat and Prescribe antidiabetic medicines for the Ageing Diabetic with heart failure Melpomeni Peppa Treat and Prescribe medications for Sexual Dysfunction in the Diabetic Female: and Male patient Christos Zouboulis Diagnose and Treat the skin problems of Ageing diabetic Ilias Migdalis

13:30-14:00

DISCUSSION

14:00-16:30

Break

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

16:30-20:45  Diabetes Care & Technology Aids for the ageing diabetic

Room A Workshop 2

(Teaching using case scenarios and consultation techniques-Interactive Programme)

16:30-17:50 All Groups together (G1,G2,G3,G4) Chairs: Antonios Polymeris, Ioannis Androulakis Alexandra Bargiota

20 min Introductory tutorial per tutor/ topic G1: Teach and Prescribe: Blood pressure Management of Ageing Diabetic with type 2 diabetes Konstantinos Makrilakis G2: Teach and Prescribe: Wearable Tech for the aging Diabetic Charilaos Dimosthenopoulos G3: Teach and Prescribe: Nutritional education and management in Aging Diabetic: Snacks, fast food, meal replacement & food supplements Nikolaos Tentolouris G4: Teach and Prescribe: The aging Diabetic with foot ulcer  18:00-19:45 Each tutor with his / her Group (G1,G2,G3,G4) Case discussion/Preparation for presentation by participants Group 1 Group 2 Group 3 Group 4

Case Preparation for presentation by the participants Case Preparation for presentation by the participants Case Preparation for presentation by the participants Case Preparation for presentation by the participants

Room A1 Room A2 Room B Room C

19:45-20:45 All Groups together (G1,G2,G3,G4). Room A Participants presentation and discussion

21:15-23.00

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Chairs:

Antonios Polymeris, Ioannis Androulakis



Participants Presentation and Discussion

Dinner for the participants

October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Saturday, 08 October 2016 07:00-08:30

Breakfast





Room A

08:30-10:00

Hormones and the Anti-ageing Challenge - Part 1



Chairs: Kyriazi Tachou Evridiki, Barbara Vlassopoulou



Session III

Christos Zouboulis How Menopause Changes the Biology of Skin: What to prescribe to benefit and not to harm Marinella Tzanele Ageing Pituitary:Deficiency when and what to replace Leonidas Duntas  Ageing thyroid and thyroxine replacement therapy: First do no harm 10:00-10:30

Coffee Break

10:30-12:00

Hormones and the Anti-ageing ChallengE - Part 2



Chairs: Dimitrios G. Goulis, Svetozar Damjanovic

SESSION III

Svetozar Damjanovic Aging Adrenal: Focus on replacement therapy in primary and secondary adrenal insufficiency Djuro Macut DHEA: To Whom, why, and when to prescribe Renato Pasquali  The aging hyperandrogenemic woman does she need special care? 12:00-13:00

Ask the Expert & Answer to your patient Refreshment Fruit, Cheese & Beverage Break

13:00-15:30  Ageing and Fertility preservation: ACTION ON TIME Case Histories

SESSION IV Teaching & Workshop All Together



Chairs: Evanthia Diamanti-Kandarakis, Djuro Macut



Shahla Nader-Eftekhari Ovarian Aging and Ovarian Reserve Tests: 20 min Nicholas Vlahos Characteristics of the Responding Ovaries post stimulation for oocyte retrieval: Ultrasonographically And Hormonally 20 min

Shahla Nader-Eftekhari Methods of Fertility Preservation and reproduction in patients With Forced Ovarian Ageing by gonadotoxic therapies: 30 min +20 min Q+A Case presentation and interaction. Questions and Answers. 15:30 Course Closing



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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

General Information

Venue: Eden Beach Hotel is located in Anavyssos. It is situated near the Saronic Gulf coast, 10 km west of Lavrio and 34 km southeast of Athens city centre. Eden Beach Hotel is the ideal choice for all leisure, business and corporate travelers. The complex, ideally complementing its natural environment, consists of two 4-star hotel units, and 240 panoramically appointed hotel rooms. Language: The official language of the Course is English. No official translation will be provided Slide Center Preview Room: The speakers are requested to hand in their presentation at least one hour prior to their scheduled Session. Badges: Name badges and relevant material will be provided on site to all registered participants. All delegates are requested to wear their name badge during the course. Please note that groups will be divided by color G1, G2, G3, G4 will have their respective colors on their badge. Certificates of Attendance: All registered delegates are entitled a Certificate of Attendance. Certificates can be collected on October 8th, 2016. Emergencies: Whilst in Greece, European Union citizens may seek any help they might need (police, ambulance, fire brigade, cost guard) by ringing from anywhere in Greece the number “112”. The number is answered by English-speaking staff, and can be dialed from public telephones or mobile telephones.

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Social program

Registrations Registration fee

(from July 30th until October 8th 2016)

With accommodation

410€

Without accommodation

260€

The Registration fee with accommodation includes: • Attendance to Lectures • Coffee Breaks • Lunch Breaks • Accommodation at EDEN HOTEL for 2 nights, 6-8/10/2016 Registration fee without accommodation includes: • Attendance to Lectures only • Coffee breaks • Lunch breaks

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October 6-8, 2016 EDEN HOTEL, Anavyssos, Athens - Greece

Acknowledgements We extend our appreciation to the following companies for their support























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Σύστημα MiniMed™ 640G

Έξυπνο Σύστημα για Καλύτερο Έλεγχο Medtronic Hellas SA Αγ. Βαρβάρας 5, 152 31 - Χαλάνδρι Αττικής www.medtronic.gr • www.medtronic-diabetes.gr Τηλ.: +30 210 6779099 • Φαξ: +30 210 6779399