US 20020044968A1
(19) United States (12) Patent Application Publication (10) Pub. No.: US 2002/0044968 A1 (43) Pub. Date:
van Lengerich (54) EMBEDDING AND ENCAPSULATION OF
(57)
SENSITIVE COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE CONTROLLED RELEASE PARTICLES
Apr. 18, 2002
ABSTRACT
Controlled release, discrete, solid particles Which contain an encapsulated and/or embedded component such as a heat
(75)
Inventor:
sensitive or readily oxidiZable pharmaceutically, biologi cally, or nutritionally active component are continuously produced Without substantial destruction of the matrix mate rial or encapsulant. A release-rate controlling component is
Bernhard H. van Lengerich,
Plymouth, MN (US) Correspondence Address:
Douglas J. Taylor, Esq.
incorporated into the matrix to control the rate of release of
General Mills, Inc.
the encapsulant from the particles. The additional compo
PO. Box 1113
nent may be a hydrophobic component or a high Water
Minneapolis, MN 55440 (US)
binding capacity component for extending the release time. The plasticiZable matrix material, such as starch, is admixed
(73) Assignee: General Mills, Inc.
With at least one plasticiZer, such as Water, and at least one
(21) Appl. No.:
09/782,320
release-rate controlling component under loW shear mixing conditions to plasticiZe the plasticiZable material Without
(22) Filed:
Feb. 13, 2001
substantially destroying the at least one plasticiZable mate rial and to obtain a substantially homogeneous plasticiZed mass. The plasticiZer content is substantially reduced and the temperature of the plasticiZed mass are substantially reduced prior to admixing the plasticiZed mass With the encapsulant to avoid substantial destruction of the encapsulant and to obtain a formable, extrudable mixture. The mixture is
Related U.S. Application Data
(62) Division of application No. 09/269,763, ?led on May 17, 1999. Publication Classi?cation
51 (52)
Im. C]7 .
.......................... ..
extruded through a die Without substantial or essentially no
B29C 4 77 / s ;A61K 9/16; A61K 9/50
U.S.Cl. ....................... .. 424/469;264/148;264/134;
264/211; 424/490
expansion and cut into discrete, relatively dense particles. Release properties may also be controlled by precoating the encapsulant and/or coating the extrudate particles With a
?lm-forming component.
i Preblended Matrix Material I\) i Water I Additional Matrix material
Pressurizin ;
Water Eva oration
Coating of Encapsulants E
Cooling
Y Addition of Encapsulants
f ........................ £999.99 ....... ..
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Patent Application Publication
Apr. 18, 2002 Sheet 1 0f 6
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Apr. 18, 2002 Sheet 4 0f 6
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US 2002/0044968 A1
Patent Application Publication
Apr. 18, 2002 Sheet 5 0f 6
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Apr. 18, 2002 Sheet 6 0f 6
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