Effect of Supplements with BlJidobacteriurn longum and Lactobacillus acidophilus on the Intestinal Microbiota during Administration of Clindamycin K. ORRHAGEt, B. BRISMARS and C. E. NORD*t$ Departments ojTMicrobiology und SSurgerj3, Hutldinge liniversity Hospital, Kuvolinsku Institute, S-141 86 Huddinge, Sweden and SNationaI Bacteriological Luhorator!,, S- I05 21 Stockholm, Sweden
Received 19 April 1993; revised 7 October 1993
Thirty healthy volunteers in three groups participated in a study of the influence of supplements containing Bijdobacterium longum and Lactobacillus ucidopiiilus on the intestinal microbiota during administration of clindamycin. All groups received clindamycin perorally q.d.s. for 7d. Group I also received a supplement with B. longum and L. ucidophilus, group I1 received a supplenient with B. longunz and group 111 received a placebo, for 21 d. The numbers of anaerobic microorganisms decreased in all groups, but the reduction of bacteroides was significantly smaller in group I than in group 111 (P
