AAC Accepts, published online ahead of print on 4 February 2008 Antimicrob. Agents Chemother. doi:10.1128/AAC.01301-07 Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Antiretroviral therapy with indinavir 400 mg-ritonavir 100 mg twice daily containing regimen in HIV-1 infected women during pregnancy. 1# 2 3 1 Jade Ghosn* , Ines De Montgolfier , Chantal Cornélie , Stéphanie Dominguez , Claire 2 4 5 1 1 Pérot , Gilles Peytavin , Anne-Geneviève Marcelin , Michèle Pauchard , Zineb Ouagari , 6 1 5 1 Manuela Bonmarchand , Rachid Agher , Vincent Calvez , François Bricaire , Marc 3 1 Dommergues , Christine Katlama and Roland Tubiana1.
D E
1/ AP-HP, Departement of Infectious Diseases, Pitié-Salpétrière Hospital, Paris, 2/ AP-HP, Department of Neonatology, Pitié-Salpétrière Hospital, Paris 3/ AP-HP, Department of Gynecology and Obstetrics, Pitié-Salpétrière Hospital, Paris 4/ AP-HP, Department of Clinical Pharmacology, Bichat-Claude Bernard Hospital, Paris 5/ AP-HP, Department of Virology, Pitié-Salpétrière Hospital, Paris 6/ AP-HP, Department of Internal Medicine, Pitié-Salpétrière Hospital, Paris
*Corresponding author: Dr Jade GHOSN, MD, PhD Department of Infectious Diseases Pitie-Salpetriere Hospital 47 Boulevard de l’Hôpital 75013 Paris France Tel : 00 33 1 42 16 01 71 Email :
[email protected]
T P
E C
C A Abstract : 54 words Article: 1175 words
#: Present affiliation: Dr Jade GHOSN, MD, PhD, AP-HP, Departement of Internal Medicine and Infectious Diseases, Bicetre Hospital, Paris Sud University, Le Kremlin-Bicêtre, France.
1
1
Abstract:
2
We evaluated safety and efficacy of indinavir/ritonavir 400/100 mg bid based therapy in
3
thirty-two HIV-infected women during pregnancy. Median indinavir trough concentration
4
was 208 ng/mL during third trimester. At delivery, 26/28 women on indinavir/ritonavir had an
5
HIV-RNA