CURRICULUM VITAE Revised: 10/22/2015 1. Name:

Kelly Rowe Bijanki, PhD

2. Office Address:

Department of Psychiatry & Behavioral Sciences Emory University School of Medicine 101 Woodruff Circle NE, Suite 4000 Atlanta, GA 30322 Telephone: (913) 484-1635

3. Email Address:

[email protected]

4. Citizenship:

U.S.A.

5. Current Titles and Affiliations: a. Academic appointments: Post-doctoral Fellow, Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, May 14, 2015-present b. Other administrative appointments: Adjunct Research Assistant Professor, Department of Neurosurgery, University of Iowa Carver College of Medicine, January, 2014-present 6. Education: 2007 BA/BA

Biology, Psychology, Truman State University, John J. Rutter PhD

2011 PhD

Neuroscience, University of Iowa, David J. Moser, PhD

7. Postgraduate Training: 2011-2014

Post-doctoral Fellowship in Clinical Neurobiology and Human Neuroimaging, University of Iowa Carver College of Medicine, Departments of Psychiatry and Neurosurgery, Nancy C. Andreasen, MD/PhD

2014-Present Post-doctoral Fellowship in Neuromodulation, Emory University School of Medicine, Departments of Psychiatry, Neurosurgery, and Neurology, Helen S. Mayberg, MD 8. Committee Memberships: a. Institutional Member, Brain Awareness Week Committee, University of Iowa, 2007-2010 Member, Brain Bee Committee, University of Iowa, 2008-2009

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Member, Neuroscience Seminar Committee, University of Iowa, 2009-2011 Chair, Neuroscience Seminar Committee, University of Iowa, 2010-2011 Chair, Psychiatry Imaging Seminar Committee, University of Iowa, 2011-2013

9. Peer Review Activities: a. Manuscript Reviews Neuropsychology American Journal of Psychiatry PLOS One Journal of Clinical and Experimental Neuropsychology

2010-present 2011-present 2011-present 2011-present

10. Editorships and Editorial Boards: Editorial Assistantship, Neurobiology, Reference Module in Biomedical Sciences, Elsevier 2014. 11. Honors and Awards: 2003, President’s Leadership Scholarship, Truman State University 2005, Summer Undergraduate Research Grant, Truman State University 2009, Jakobsen Graduate Research Conference, Biological and Health Sciences Award 2008, Society for Neuroscience Postdoctoral Fellow Travel Award 12. Society Memberships: 2007-present 2008-present 2009-present 2011-present 2013-present

Society for Neuroscience (SFN) Cognitive Neuroscience Society (CNS) American Academy for the Advancement of Science (AAAS) International Society of Vascular Behavioral and Cognitive Disorders World Society for Stereotactic and Functional Neurosurgery (WSSFN)

13. Formal Teaching: a. Medical Student Teaching: 2009: Teaching Assistant – University of Iowa Carver College of Medicine, Medical Neuroscience Course. Taught graduate and medical students in laboratory section of medical neuroscience, including dissection of post-mortem brain tissue and preparation of laboratory examinations (Approximately 2 hours preparation and 4 hours delivery per week). b. PhD Programs: 2009: Teaching Assistant – University of Iowa Department of Biology, Fundamental Neurobiology Course. Instructed discussion section in fundamental

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neurobiology, designed weekly quiz materials, assisted with grading of essay and short answer examinations (Approximately 4 hours preparation and 6 hours delivery per week). c. Undergraduate: 2006-2007: Teaching Assistant – Truman State University Department of Biology, Physiology Course. Assisted in assembling course materials, grading examinations, running physiology laboratory section (Approximately 4 hour preparation and 4 hour delivery per week). 2010: Invited Lecturer – University of Iowa Department of Psychology, Introduction to Clinical Psychology Course. Taught lecture on major psychological considerations in the elderly, focusing on dementia and depression to approximately 220 undergraduate psychology students (Approximately 3 hour preparation and 2 hour delivery). d. Formal Training in College Teaching; Seminar in College Teaching (Fall 2011) Teaching and Learning in Higher Education (Fall 2012) Teaching Practicum in Seminar in College Teaching (Fall 2012) 14. Supervisory Teaching: a. Mentorship: Eddie Valentin, graduate student, 2014-2015. Advised on the development of a Ph.D. dissertation research project and corresponding manuscript Brendan Hodis, medical student, 2012-2014. Advised on development of two manuscripts, applications to graduate school and M.D./Ph.D. programs. Emily Harlynn, research assistant, 2012-2014. Advised on development on one manuscript and applications to clinical psychology programs. Meredith Hoyland, undergraduate student, summer 2012. Oversaw research on neuroimaging in schizophrenia, and a research project in atherosclerotic vascular disease. Katie Leick, medical student, summer 2011. Taught principles and techniques of diffusion tensor imaging, troubleshooting with data processing and analysis. Joshua Timpe, medical student, summer 2010. Taught principles and techniques of diffusion tensor imaging, assisted in data analysis, reviewed poster and manuscript. Adam Ruggle, medical student, 2009. Oversaw research on use of selective serotonin reuptake inhibitor medications in patients with Huntington’s disease.

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15. Lectureships and invited seminars a. National and International “Diffusion tensor imaging in the atherosclerotic brain: implications for depression and cognition”. International Society of Vascular Behavioural and Cognitive Disorders Congress, Lille, France, September 2011. “In Search of Neurobiological Correlates To Depression: Electrical Stimulation of the Amygdala”, World Society for Stereotactic and Functional Neurosurgery Quadrennial Congress, Tokyo, Japan, May 2013. b. Institutional “Diffusion Tensor Imaging”, Department of Psychiatry Imaging Seminar, University of Iowa Carver College of Medicine, June 2011 and June 2012. Taught class of post-doctoral fellows, graduate students, and faculty members on the use of diffusion tensor imaging in psychiatric illness. “Diffusion Tensor Imaging and Depressive Symptoms in Vascular Disease”, Department of Psychiatry Research Rounds, University of Iowa Carver College of Medicine, December 2011. Presented findings from Ph.D. thesis for the faculty and students of the Department of Psychiatry. “Brain structural correlates of depression and schizophrenia: potential targets for neurosurgical intervention”, Department of Neurosurgery, University of Iowa Carver College of Medicine, February 2012. Presented current research and ideas for expansion of deep brain stimulation therapy for the treatment of auditory hallucinations in schizophrenia. 16. Abstract Presentations at Conferences (ORCID: 0000-0003-1624-8767)

1. Inman, CS, Bijanki, KR, Bass, DI, Manns, JR, Gross, RE, Hamann, S, Willie, JT. Effects of brief electrical stimulation to the amygdala in humans on memory for neutral stimuli. Cognitive Neuroscience Society, New York, NY, 2016.

2. Parker, KL, Kim, Y, Kelly, R, Ewald, VA, Han, Y, Bijanki, KR, Andreasen, NC, Narayanan NS. A neurophysiologic basis for the therapeutic potential of cerebellar stimulation on cognition in schizophrenia. Society for Neuroscience, Chicago, IL, 2015.

3. Bijanki KR, Matsui JT, Mayberg HM, Magnotta VA, Arndt S, Johnson HJ, Nopoulos P, Paradiso S, McCormick LM, Fiedorowicz JG, Epping EA, Moser DJ. Low fractional anisotropy of the right ventral anterior cingulate related to depressive symptoms in atherosclerotic vascular disease. American College of Neuropsychopharmacology Annual Meeting, Hollywood, Florida, 2013.

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4. Bijanki, KR, Kovach C, McCormick LM, Kawasaki H, Wemmie J, Dlouhy B, Howard MA. In search of neurobiological correlates to depression: electrical stimulation of the amygdala. World Society for Stereotactic and Functional Neurosurgery Meeting, Tokyo, Japan, 2013.

5. Rowe, K.C., Magnotta, V.A., Matsui, J.T., Vitense, K., Axelson, E., Brumm, M., Arndt, S., Paradiso, S., Nopoulos, P., and Moser, D.J.. Relationships among white matter health, depression, and cognition: A diffusion tensor imaging study. Cognitive Neuroscience Society Conference, Chicago, IL, 2012.

6. Rowe, K.C., Magnotta, V.A., Matsui, J.T., Vitense, K., Axelson, E., Brumm, M., Arndt, S., Paradiso, S., Nopoulos, P., and Moser, D.J., Diffusion tensor imaging in the atherosclerotic brain: implications for depression, processing speed, and attention. Society for Neuroscience Conference, Washington, DC, 2011; International Society of Vascular Behavioral and Cognitive Disorders Conference, Lille, France, 2011.

7. Rowe, K.C., Vitense, K., Axelson, E., Magnotta, V.A., Nopoulos, P, and Moser, D.J., Diffusion Tensor Imaging: revealing hidden connections between vascular disease, emotion, and cognition. University of Iowa Neuroscience Research Week, 2011.

8. Epping, E.A., Mills, J., Smith, M.M., Beglinger, L.J., Rowe, K.C., Fiedorowicz, J.G., Paulsen, J.S., and the PREDICT-HD Investigators of the Huntington Study Group. Depression in Prodromal Huntington Disease. Huntington Study Group Conference, 2010.

9. Timpe, J., Rowe, K.C., Matsui, J.T., Magnotta, V.A., and Denburg, N.L. White matter integrity as measured by diffusion tensor imaging distinguishes between impaired and unimpaired older adult decision-makers. University of Iowa Medical Student Research Day, 2010.

10. Moser, D.J., Rowe, K.C., Magnotta, V.A., Haynes, W., Nopoulos, P. Cerebral White Matter Volume is Associated with Forearm Vascular Function in Elderly Men with Vascular Disease. American College of Neuro- Psychopharmacology Conference, Miami Beach, FL, 2010.

11. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Mills, J., Fiedorowicz, J., Epping, E., and Moser, D.J. SSRI usage in Prodromal Huntington Disease. Jakobsen Graduate Conference, Iowa City, IA, 2010.

12. Rowe, K.C., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Moser, D.J., O’Rourke, J.J.F., Stout, J., Queller, S., Paulsen, J.S., and the Predict-HD investigators of the Huntington Study Group. Self-Paced Timing Task Detects Subtle Changes in Pre-Diagnosed Huntington Disease. World Congress on Huntington Disease, Vancouver, Canada, 2009.

13. Rowe, K.C., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Moser, D.J., O’Rourke, J.J.F., Stout, J., Rao, S., Queller, S., Paulsen, J.S., and the Predict-HD investigators of the Huntington Study Group. Self-Paced Timing Task in Pre-diagnosed Huntington’s disease. Cognitive Neuroscience Society Conference, San Francisco, CA, 2009

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14. Rowe, K.C., Beglinger, L., Wang, C., Langbehn, D., Duff, K., Paulsen, J.S., and the Predict-HD Investigators of the Huntington Study Group. Antidepressant use in PredictHD: Patterns of use relevant to “Naturalistic” drug studies. Huntington Study Group Clinical Research Symposium, Tampa, FL, 2008.

15. Rowe, K.C., Paulsen, J., Nopoulos, P., Beglinger, L., Johnson, H., Magnotta, V., Pierson, R., Langbehn, D., Aylward, E. White Matter Volume in Pre-diagnosed Huntington’s Disease. Society for Neuroscience Conference, Washington, DC, 2008.

16. Wang, Q., Rowe, K.C., Green, S. P-75NTR signaling promotes IHC-SGN synapse regeneration after excitotoxic trauma. Auditory Research Organization Conference, 2007. 17. Research focus: My primary research interest explores the neurobiological, behavioral, and electrophysiological correlates of human behavior and psychopathology, particularly related to the effects of neuromodulation on affective neural circuit function and implications for our understanding of the circuit across psychiatric and neurological patient populations. 18. Grant Support: a. Active support: i. Federally funded: Mayberg (PI) 04/01/05-06/30/19 5R01MH073719-06 $814,365 total directs Testing an Imaging Biomarker for Treatment Stratification in Major Depression. This project tests the efficacy of a novel imaging biomarker developed to stratify patients into two subtypes that predict the likelihood of remission to monotherapy with cognitive behavioral therapy (CBT) or escitalopram (sCIT)--two first-line treatments for MDD. Role on Project: Post-doctoral Fellow Drane (PI) 01/07/14-30/04/19 1R01NS088748-01 $634,658 total directs Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe Structures. This project compares the cognitive outcome of patients undergoing standard open resections versus a novel, minimally invasive laser ablation technique that is exquisitely restricted to the hippocampus and amygdala. As open resections affect a broader range of temporal lobe white matter and structures, this study will determine whether the hippocampus and amygdala have an essential role in cognitive processes. Role on Project: Post-doctoral Fellow ii. Privately funded: Bijanki (PI) 10/01/14-09/30/15 YIG-0-015-13 American Foundation for Suicide Prevention $39,866 total directs Direct electrical stimulation of the amygdala: Impact on suicidal ideation, depression, and anxiety. The goal of this study is to utilize electrical brain stimulation to map the

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function of the amygdala in awake, behaving human research participants, focusing on implications for patients with major mental illness. Role on project: Principal Investigator b. Previous Support i. Federally funded: Rilling (PI) 09/01/14-03/31/16 R21 HD078778-01 $182,055 total directs Neurobiological Bases of Paternal Nurturance. The goal of this study is to characterize the effects of treatment with neuropeptides oxytocin and arginine vasopressin on empathetic brain activation in human fathers interacting with their own children. This area of study aims to elucidate mechanisms of affect regulation in fathers during a time of intense emotional and physical stress: the newborn period. Role: Post-doctoral Fellow Andreasen (PI) 12/15/11-08/14/14 T32 MH019113-22 $231,555 total directs Research Training in the Major Psychoses and Clinical Neurobiology. The goal of this project is to provide training in translational clinical neuroscience, focusing on neuroimaging and cognitive neuroscience related to major mental illness. Role: Post-doctoral Fellow Howard (PI) 09/15/12-08/14/14 5R01 DC004290-14 $574,051 total directs Human Auditory Cortex Physiology. The goal of this project is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing by combining anatomical and functional MRI methods with direct cortical electrophysiological recordings and electrical stimulation techniques in awake, behaving human subjects undergoing clinical evaluation of intractable epilepsy. Role: Post-doctoral Fellow Moser (PI) 06/15/09-12/15/11 5R01 AG030417-05 $469,862 total directs Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease. The goal of this project is to determine the relationship between vascular function and specific MRI-based brain measures (both cross-sectionally and longitudinally) in patients with atherosclerotic vascular disease, and to conduct a pilot study on vascular function and MRI- based brain measures in healthy comparison participants. Role: Graduate Student Paulsen (PI) 04/01/00-08/31/08 5R01NS040068-07 $5,717,035 directs Neurobiological Predictors of Huntington’s Disease. The goal of this project is to develop a stable platform from which to study the progression toward manifest Huntington’s disease in people who are confirmed carriers of the HD gene but who have not yet begun showing motor symptoms. Research targets include characterizing affected brain circuitry via neuroimaging and measuring early

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effects of the disease on mood and behavior. Role: Graduate Student Tranel (PI) 09/07/99-30/06/09 5T32NS007421-09 $204,000 total directs Neuroscience Training Program. This training award provides support for broad-based, fundamental, predoctoral (prethesis) training in neuroscience. ii. Privately Funded Bijanki (PI) 10/1/12-10/1/13 University of Iowa PET Imaging Center Pilot Grant $9,000 total directs Pilot Scans for O15-PET examination of stimulation effects on cerebral blood flow. This pilot funding supported the collection of ON and OFF stimulation neuroimaging for 10 patients receiving deep brain stimulation for treatment-refractory obsessivecompulsive disorder. 19. Bibliography: a. Published and accepted research articles: 1. Bijanki, K.R., Matsui, J.T., Mayberg, H.S., Magnotta, V.A., Arndt, S., Johnson, H.J., Nopoulos, P., Paradiso, S., McCormick, L., Fiedorowicz, J.G., Epping, E.A., Moser, D.J. (2015). Depressive symptoms related to low fractional anisotropy in the right ventral anterior cingulate in older adults with atherosclerotic vascular disease. Frontiers in Human Neuroscience. 2. Bijanki, K.R., Hodis, B., Brumm, M., Harlynn, E, McCormick, L.M. (2014). Hippocampal and subcallosal cingulate atrophy in psychotic depression. PLoS ONE 9(10): e110770. DOI: 10.1371/journal.pone.0110770. 3. Bijanki, K.R., Kovach, C., McCormick, L.M., Kawasaki, H., Dlouhy, B., Feinstein, J., Jones, R.D., Howard, M. (2014). Case report: Stimulation of the right amygdala produces transient changes in affective bias. Brain Stimulation 7(5): 690-693. NIHMSID: 601564. DOI: 10.1016/j.brs.2014.05.005. 4. Bijanki, K.R., Hodis, B., Magnotta, V.A., Zeien, E., Andreasen, N.C. (2015). Effects of age on white matter integrity and negative symptoms in schizophrenia. Schizophrenia Research 161(1): 29-35. NIHMSID: 598488. DOI: 10.1016/j.schres.2014.05.031. 5. Epping, E.A., Mills, J.A., Beglinger, L.J., Fiedorowicz, J.G., Craufurd, D., Smith, M.M., Groves, M., Bijanki, K.R., Downing, N., Williams, J.K., Long, J.D., Paulsen, J.S., and the PREDICT-HD Investigators and Coordinators of the Huntington Study Group. (2013). Characterization of depression in prodromal Huntington disease: the PREDICTHD study. Journal of Psychiatric Research, 47(10) 1423-1431. 6. Bijanki, K.R., Arndt, S., Magnotta, V.A., Nopoulos, P., Paradiso, S., Matsui, J.T., Johnson, H.J., Moser, D.J. (2013a). Characterizing white matter health in atherosclerotic vascular disease. Psychiatry Research: Neuroimaging. NIHMSID: 533721

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7. Bijanki, K.R., Stillman, A.N., Arndt, S., Magnotta, V., Fiedorowicz, J.G., Haynes, W., Matsui, J.T., Johnson, H.J., W., Moser, D.J. (2013b). White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis. International Journal of Geriatric Psychiatry, 28(10) 1069-1076. NIHMSID: 441354. 8. Beglinger, L.J., Prest, L., Mills, J.A., Paulsen, J.S., Smith, M., Gonzalez-Alegre, P., Rowe, K.C., Nopoulos, P., Uc, E.Y. (2012). Clinical predictors of driving status in Huntington disease. Movement Disorders. PMID: 22744778. 9. Stillman, A.N., Rowe, K.C., Arndt, S., Moser, D.J. (2012). Anxious symptoms and cognitive function in non-demented elderly adults: an inverse relationship. International Journal of Geriatric Psychiatry, 27(8) 792-798. PMCID: 3391343. 10. Timpe, J.C., Rowe, K.C., Matsui, J.K., Magnotta, V.A., Denburg, N.L. (2011). White matter integrity, as measured by diffusion tensor imaging, distinguishes between impaired and unimpaired older decision-makers. Journal of Cognitive Psychology 23 (6 SI) 760-767. NIHMS579050 11. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Wang, C., Mills, J., Beglinger, L.J., Smith, M.M., Epping, E.A., Fiedorowicz, J., Duff, K., Ruggle, A., Moser, D.J., and the PREDICT-HD Investigators of the HSG. (2012). Patterns of Serotonergic Antidepressant Usage in Prodromal Huntington Disease. Psychiatry Research, 196(2-3) 309-314. PMID: 22397915. 12. Downing N., Smith M.M., Beglinger L.J., Mills J., Duff K., Rowe K.C., Epping E., Paulsen J.S., and the PREDICT-HD Investigators of the HSG. (2012). Perceived Stress in Prodromal Huntington Disease. Psychology & Health, 27(2) 196-209. PMCID: 3165107. 13. O’Rourke, J.J.F., Beglinger, L.J., Smith, M.R., Mills, J., Moser, D.J., Rowe, K.C., Langbehn, D.R., Duff, K., Stout, J.C., Harrington, D.L., Carlozzi, N., Paulsen, J.S., and the PREDICT-HD Investigators of the Huntington Study Group. (2010). Cognitive, Motor, and Psychiatric Contributions to the Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance. Journal of Clinical and Experimental Neuropsychology, 33 (5) 567-579. PMCID: 3159183. 14. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., O’Rourke, J.J.F., Stout, J., Moser, D.J., and the PREDICT-HD Investigators of the Huntington Study Group. (2010). Self-Paced Timing Detects and Tracks Change in Prodromal Huntington Disease. Neuropsychology, 24, 435-442. PMCID: 2900808. b. Manuscripts Submitted: 1. Asp, E.W., Warner, K., Andreasen, N.C., Bijanki, K.R., Denburg, N.L., Tranel, D. (2014, submitted). Prefrontal-parietal network critical for falsification of novel information. Psychological Science.

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