CURRICULUM VITAE The Johns Hopkins University School of Medicine

DEMOGRAPHIC INFORMATION Current Appointments: Associate Professor of Neurology, The Johns Hopkins University School of Medicine Full-time Staff, The Johns Hopkins Hospital Personal Data: The Johns Hopkins Hospital Department of Neurology Meyer Building, Room 2-147 600 North Wolfe Street Baltimore, Maryland 21287-7247 Tel: (410) 955-6772 FAX: (410) 955-0751 email: [email protected] Education and Training: Undergraduate B.S., 1985 Louisiana State University in Shreveport Six-year B.S./M.D. Cooperative Program in Medicine, 1981-1985 Doctoral M.D., 1987 Louisiana State University School of Medicine in Shreveport, 1983-1987 Postdoctoral 1987-1988 1988-1991 1991-1993 1993-1994

Medical Internship, Baylor College of Medicine, Houston, TX Neurology Residency, University of Chicago, Pritzker School of Medicine Epilepsy and Clinical Neurophysiology Fellowship, The Johns Hopkins University Cognitive Neurology Fellowship, The Johns Hopkins University

Professional Experience: 1994-1996 Instructor, Department of Neurology, The Johns Hopkins University 1996-2006 Assistant Professor, Department of Neurology, The Johns Hopkins University 2006Associate Professor, Department of Neurology, The Johns Hopkins University RESEARCH ACTIVITIES Peer Reviewed Original Science Publications: (H-index: 27) 1. Crone N, Reder T. Severe tetanus in immunized patients with high anti-tetanus titers. Neurology 1992;42:761-764. 2. Hart, J., Crone, N., Lesser, R., Sieracki, J., Miglioretti, D., Hall, C., Sherman, D. & Gordon, B. Temporal dynamics of verbal object comprehension. Proc Nat Acad Sci USA 1998;95:6498-6503. 3. Crone NE, Miglioretti DL, Gordon B, Sieracki JM, Wilson MT, Uematsu S, Lesser RP. Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis I. Alpha and beta event-related desynchronization. Brain 1998;121:2271-2299. 4. Crone NE, Miglioretti DL, Gordon B, and Lesser RP. Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis II. Event-related synchronization in the gamma band. Brain 1998;121:2301-2315. 5. Moriarity JL, Wetzel M, Clatterbuck RE, Javedan S, Sheppard JM, Hoenig-Rigamonti K, Crone NE, Breiter SN, Lee RR, Rigamonti D. The natural history of cavernous malformations: a prospective study of 68 patients. Neurosurgery 1999;44:1166-71. 1

6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26.

Lenz FA, Krauss G, Treede RD, Lee JL, Boatman D, Crone N, Minahan R, Port J, Rios M. Different generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditoryevoked potentials, and event-related potentials. Neuroscience Letters 2000;279:153-6. Boatman D, Alidoost M, Bergey G, Gordon B, Crone N, Hart J, Lenz F. Right hemisphere language dominance in a right-handed patient with late-onset seizures. Epilepsy & Behavior 2000;1(4):281-286. Crone NE, Boatman D, Gordon B, Hao L. Induced electrocorticographic gamma activity during auditory perception. Clinical Neurophysiology 2001;112(4):565-581. Crone NE, Hao L, Hart J, Boatman D, Lesser RP, Irizarry R, Gordon B. Electrocorticographic gamma activity during word production in spoken and sign language. Neurology, 2001; 57(11):2045-2053 (editorial on pp. 1947-1948). Motamedi GK, Lesser RP, Miglioretti DL, Mizuno-Matsumoto Y, Gordon B, Webber WR, Jackson DC, Sepkuty JP, Crone NE. Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. Epilepsia 2002;43(8):836-846. Crone NE, Hao L. Functional dynamics of spoken and signed word production: a case study using electrocorticographic spectral analysis. Aphasiology, 2002;16(9):903-926. Ray S, Jouny CC, Crone NE, Boatman D, Thakor NV, Franaszczuk PJ. Human ECoG analysis during speech perception using matching pursuit: A comparison between stochastic and dyadic dictionaries. IEEE Signal Processing, 2003 Dec;50(12):1371-3. Ohara S, Crone NE, Weiss N, Treede, R-D, Lenz FA. Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans. Journal of Neurophysiology, 2004 Jun;91(6):2734-46. Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clinical Neurophysiology, 2004;115(7):1641-1652. Kirsch (Majors) HE, Sepkuty JP, Crone NE. Multimodal functional mapping of sensorimotor cortex prior to resection of an epileptogenic perirolandic lesion. Epilepsy and Behavior, 2004;5(3):407-10. Ohara S, Crone NE, Weiss N, Vogel H, Treede RD, Lenz FA. Attention to pain is processed at multiple cortical sites in man. Experimental Brain Research, 2004 Jun;156(4):513-7. Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity. Pain. 2004 Jul;110(1-2):318-28. Sinha SR, Crone NE, Fotta R, Lenz F, Boatman DF. Transient unilateral hearing loss induced by electrocortical stimulation. Neurology,2005;64(2):383-5. Crone NE, Jinnah H, Reich S. Wilson’s disease presenting with an unusual cough. Movement Disorders, 2005 Jul;20(7):891-3. Koubeissi MZ, Crone NE, Lesser RP. Seizures manifesting as an urge to defecate, with an ictal discharge in the right hemisphere. Epilepsia. 2005 Aug;46(8):1330-2. Zygierewicz J, Durka PJ, Klekowicz H, Franaszczuk P, Crone NE. Computationally efficient approaches to calculating significant ERD/ERS changes in the time-frequency plane. Journal of Neuroscience Methods, 2005 Jun 30;145(1-2):267-76. Kaminski M, Zygierewicz J, Kus R, Crone N. Analysis of multichannel biomedical data. Acta Neurobiologiae Experimentalis, 2005; 65(4):443-52. Sinai A, Bowers CW, Crainiceanu CM, Boatman D, Gordon B, Lesser RP, Lenz FA, Crone NE. Electrocorticographic high gamma activity during naming vs. electrical cortical stimulation. Brain, 2005 Jul;128(Pt 7):1556-70. Boatman D, Lesser R, Crone N, Krauss G, Lenz F, & Miglioretti D. Speech recognition impairments in patients with right temporal lobe epilepsy. Epilepsia, 2006 Aug; 47(8):1397-401. Ohara S, Crone NE, Weiss N, Lenz FA. Analysis of synchrony demonstrates 'pain networks' defined by rapidly switching, task-specific, functional connectivity between pain-related cortical structures. Pain, 2006 Aug;123(3):244-53. Zygierewicz J, Mazurkiewicz J, Durka PJ, Franaszczuk PJ, Crone NE. Estimation of short-time crosscorrelation between frequency bands of event related EEG. Journal of Neuroscience Methods, 2006 Oct 30; 157(2):294-302.

27. Hatfield LA, Crone NE, Kossoff EH, Ewen JB, Pyzik PL, Lin DD, Kelley TM, Comi AM. Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome. Epilepsia, 2007 Jan;48(1):191-5. 28. Ritzl, EK, Wohlschlaeger, AM, Crone, NE, Wohlschlaeger, A, Gingis, L, Bowers, CW, Boatman, DF: Transforming electrocortical mapping data into standardized common space. Clinical EEG and Neuroscience, 2007 Jul;38(3):132-6. 29. Kleinman JT, Sepkuty JP, Hillis AE, Lenz FA, Heidler-Gary J, Gingis L, Crone NE. Spatial neglect during electrocortical stimulation mapping in the right hemisphere. Epilepsia, 2007 Dec;48(12):2365-8. Epub 2007 Jul 21. 30. Ray S, Niebur E, Hsiao SS, Sinai A, and Crone NE. High-frequency gamma activity (80-150 Hz) is increased in human cortex during selective attention. Clinical Neurophysiology, 2008 Jan;119(1)116-33. PMC2444052 31. Ohara S, Crone NE, Weiss N, Kim JH, Lenz FA. Analysis of synchrony demonstrates that the presence of “pain networks” prior to a noxious stimulus can enable the perception of pain in response to that stimulus. Experimental Brain Research, 2008 Feb;185(2):353-8. Epub 2008 Jan 30. 32. Lesser RP, Lee HW, Webber WRS, Prince B, Crone N, Miglioretti DL. Short-term variations in response distribution to cortical stimulation. Brain, 2008 Jun;131(6):1528-39. Epub 2008 Mar 12. 33. Ray S, Hsiao SS, Crone NE, Franaszczuk PJ, Niebur E. Effect of stimulus intensity on spike-LFP relationship in secondary somatosensory cortex. Journal of Neuroscience, 2008 Jul 16; 28(29):7334-43. PMC2597587 34. Testa SM, Ward J, Crone NE, Brandt J. Stimulus type affects Wada memory performance. Epilepsy & Behavior. 2008 Oct; 13(3):458-62. 35. Korzeniewska A, Crainiceanu CM, Kuś R, Franaszczuk PJ, Crone NE. Dynamics of event-related causality (ERC) in brain electrical activity. Human Brain Mapping, 2008 Oct;29(10):1170-92. 36. Ray S, Crone NE, Niebur E, Franaszczuk PJ, Hsiao SS. Neural correlates of high-gamma oscillations (60200 Hz) in macaque local field potentials and their potential implications in electrocorticography. Journal of Neuroscience, 2008 Nov 5;28(45):11526-36. PMC2715840 37. Lee HW, Shin JS, Webber WR, Crone NE, Gingis L, Lesser RP. Reorganization of cortical motor and language distribution in human brain. Journal of Neurology, Neurosurgery, and Psychiatry. 2009 Mar;80(3):285-90. 38. Sinai A, Crone NE, Wied H, Franaszczuk PJ, Miglioretti D, Boatman-Reich D. Intracranial mapping of auditory perception: Event-related recordings and electrocortical stimulation. Clinical Neurophysiology, 2009 Jan;120(1):140-9. PMC2819074 39. Ewen JB, Kossoff EH, Crone NE, Lin DD, Lakshmanan BM, Ferenc LM, Comi AM. Use of quantitative EEG in infants with port-wine birthmark to assess for Sturge-Weber brain involvement. Clinical Neurophysiology. 2009 Aug;120(8):1433-40. PMC2754702 40. Boatman-Reich D, Franaszczuk PJ, Korzeniewska A, Caffo B, Ritzl EK, Colwell S, Crone NE. Quantifying auditory event-related responses in multichannel human intracranial recordings. Frontiers in Computational Neuroscience, 2010 Mar;4(4): 1-17. PMC2859880 41. Lee HW, Webber WR, Crone N, Miglioretti DL, Lesser RP. When is electrical cortical stimulation more likely to produce afterdischarges? Clinical Neurophysiology, 2010 Jan;121(1):14-20. PMC2852681 42. Acharya S, Fifer MS, Benz HL, Crone NE, Thakor NV. Electrocorticographic amplitude predicts finger positions during slow grasping motions of the hand. Journal of Neural Engineering, 2010 Aug;7(4):046002. PMC4021582 43. Voytek B, Canolty RT, Shestyuk A, Crone N, Parvizi J, Knight RT. Shifts in gamma phase-amplitude coupling frequency from theta to alpha over posterior cortex during visual tasks. Frontiers in Human Neuroscience, 2010(4):191. PMC2972699. 44. Flinker A, Chang E, Kirsch H, Barbaro N, Crone NE, and Knight R. Single-Trial Speech Suppression of Auditory Cortex Activity in Humans. Journal of Neuroscience, 2010; 30: 16643-16650. PMC3010242. 45. Liu CC, Shi CQ, Franaszczuk PJ, Crone NE, Schretlen D, Ohara S, Lenz FA. Painful laser stimuli induce directed functional interactions within and between the human amygdala and hippocampus. Neuroscience 2011;178:208-17. PMC3048957.

46. Cervenka MC, Boatman-Reich D, Ward J, Franaszczuk PJ, Crone NE. Language mapping in multilingual patients: Electrocorticography and cortical stimulation during naming. Frontiers in Human Neuroscience, 2011;5:13. PMC3044479. 47. Korzeniewska A, Franaszczuk PJ, Crainiceanu CM, Kus R, Crone NE. Dynamics of large-scale cortical interactions at high gamma frequencies during word production: Event related causality (ERC) analysis of human electrocorticography (ECoG). NeuroImage, 2011; 56(4): 15 June 2011, 2218-2237. NIHMS288725. PMC3105123 [Available on 2012/6/15] 48. Liu CC, Crone NE, Franaszczuk PJ, Cheng DT, Schretlen DS, Lenz FA. Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus, and frontal lobe. Neuroscience. 2011 Jun 12. [Epub ahead of print] NIHMS307888. 49. Koubeissi MZ, Lesser RP, Sinai A, Gaillard WD, Franaszczuk P, Crone NE. Connectivity between perisylvian and bilateral basal temporal cortices. Cerebral Cortex, 2012 Apr;22(4):918-25. Epub 2011 Jun 29. PMC3306577. 50. Ewen JB, Moher JS, Lakshmanan BM, Ryan M, Xavier P, Crone NE, Denckla MB, Egeth H, Mahone EM. Multiple Task Interference is Greater in Children with ADHD. Developmental Neuropsychology. 2011 2012 Feb;37(2):119-33. PMC3313619. 51. Liu CC, Ohara S, Franaszczuk PJ, Crone NE, Lenz FA. Attention to painful cutaneous laser stimuli evokes directed functional interactions between human sensory and modulatory pain-related cortical areas. Pain. 2011 Oct 25. [Epub ahead of print] 52. Benz H, Zhang H, Bezerianos A, Acharya S, Crone N, Zheng X, Thakor N. Connectivity analysis as a novel approach to motor decoding for prosthesis control. IEEE Trans Neural Syst Rehabil Eng. 2012 Mar;20(2):143-52. PMC3327125. 53. Pasley BN, David SV, Mesgarani N, Flinker A, Shamma SA, Crone NE, Knight RT, Chang EF. (2012) Reconstructing speech from human auditory cortex. PLoS Biology, 2012 Jan;10(1):e1001251. PMC3269422. 54. Parameshwaran D, Crone NE, Thiagarajan TC. Coherence potentials encode simple human sensorimotor behavior. PLoS One. 2012;7(2):e30514. PMC3272042 55. Cervenka MC, Franaszczuk PJ, Crone NE, Hong B, Caffo BS, Bhatt P, Lenz FA, Boatman-Reich D. Reliability of early cortical auditory gamma-band responses. Clinical Neurophysiology. 2013 Jan;124(1):7082. PMC3468656 56. Voytek B, D'Esposito M, Crone N, Knight RT. A method for event-related phase/amplitude coupling. Neuroimage, 2013 Jan 1; 64: 416-24. PMC3508071. 57. Cervenka MC, Corines J, Boatman-Reich DF, Eloyan A, Sheng X, Franaszczuk PJ, Crone NE. Electrocorticographic functional mapping identifies human cortex critical for auditory and visual naming. Neuroimage, 2013 Apr 1; 69: 267-76. PMC3612948 58. Markman T, Liu CC, Chien JH, Crone NE, Zhang J., and Lenz FA. EEG analysis of scalp EEG reveals widespread directed functional interactions related to a painful cutaneous laser stimulus. Journal of Neurophysiology. 2013 Nov;110(10):2440-9. PMC3841864 [Available on 2014/11/15] 59. Fifer MS, Hotson G, Wester BA, McMullen DM, Wang Y, Johannes MS, Katyal KD, Helder JB, Para MP, Vogelstein RJ, Anderson WS, Thakor NV, Crone NE. Simultaneous Neural Control of Simple Reaching and Grasping with the Modular Prosthetic Limb using Intracranial EEG. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2014 May;22(3):695-705. 2013 Oct 24 [Epub ahead of print]. PMC4030429. 60. McMullen DP, Hotson G, Katyal KD, Wester BA, Fifer MS, McGee TG, Harris A, Johannes MS, Vogelstein RJ, Ravitz AD, Anderson WS, Thakor NV, Crone NE. Demonstration of a semi-autonomous hybrid brainmachine interface using human intracranial EEG, eye tracking, and computer vision to control a robotic upper limb prosthetic. IEEE Transactions on Neural Systems and Rehabilitation Engineering. Jul 2014; 22(4):784-796. 2013 Dec 12. [Epub ahead of print] PMC4057363 61. Kanas, VG, Mporas I, Benz HL, Sgarbas KN, Bezerianos A, Crone NE. Joint spatial-spectral feature space clustering for speech activity detection from ECoG signals. IEEE Transactions on Bio-Medical Engineering. 2014 Apr; 61(4):1241-50. PMC4005607 62. Korzeniewska A, Cervenka MC, Jouny CC, Perilla JR, Harezlak J, Bergey GK, Franaszczuk PJ, Crone NE. Ictal propagation of high frequency activity is recapitulated in interictal recordings: Effective connectivity of epileptogenic networks recorded with intracranial EEG. Neuroimage. 2014 Jul 5. [Epub ahead of print] PubMed PMID: 25003814.

63. Martin S, Brunner P, Holdgraf C, Heinze HJ, Crone NE, Rieger J, Schalk G, Knight RT, Pasley BN. Decoding spectrotemporal features of overt and covert speech from the human cortex. Frontiers in Neuroengineering. 2014 May 27;7:14. PMC4034498. 64. Tang H, Buia C, Madhavan R, Crone NE, Madsen JR, Anderson WS, Kreiman G. Spatiotemporal Dynamics Underlying Object Completion in Human Ventral Visual Cortex. Neuron. 2014 Jul 16. pii: S08966273(14)00539-X. doi:10.1016/j.neuron.2014.06.017. [Epub ahead of print] PubMed PMID: 25043420. 65. Vinjamuri R, Patel V, Powell M, Mao Z-H, Crone N. Candidates for Synergies: Linear Discriminants versus Principal Components. Computational Intelligence and Neuroscience 2014;2014:10. 66. Eliades SJ, Crone NE, Anderson WS, Ramadoss D, Lenz FA, Boatman-Reich D. Adaptation of highgamma responses in human auditory association cortex. Journal of Neurophysiology 2014 Aug 13. pii: jn.00207.2014. [Epub ahead of print] PMID: 25122702 67. Szczepanski SM, Crone NE, Kuperman RA, Auguste KI, Parvizi J, and Knight RT. Dynamic Changes in PhaseAmplitude Coupling Facilitate Spatial Attention Control in Fronto-Parietal Cortex. PLoS Biol, vol. 12, no. 8, p. e1001936, Aug. 2014. 68. Burns SP, Santaniello S, Yaffe RB, Jouny CC, Crone NE, Bergey GK, Anderson WS, Sarma SV. Network dynamics of the brain and influence of the epileptic seizure onset zone. Proc Natl Acad Sci USA. 2014 Dec 9;111(49):E5321–5330. 69. Suffczynski P, Crone NE, Franaszczuk P. Afferent inputs to cortical fast-spiking interneurons organize pyramidal cell network oscillations at high-gamma frequencies (60 - 200 Hz). J Neurophysiol. 2014 Sep 10;jn.00844.2013. PMC4254875

70. Ewen JB, Lakshmanan BM, Hallett M, Mostofsky SH, Crone NE, Korzeniewska A. Dynamics of functional and effective connectivity within human cortical motor control networks. Clin Neurophysiol. 2014 Sep 18; 71. Madhavan R, Millman D, Tang H, Crone NE, Lenz FA, Tierney TS, Madsen JR, Kreiman G, Anderson WS. Decrease in gamma-band activity tracks sequence learning. Front Syst Neurosci. 2014;8:222. 72. Hotson G, Fifer MS, Acharya S, Benz HL, Anderson WS, Thakor NV, Crone NE. Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions. PLoS ONE. 2014;9(12):e115236. PMC4278860 73. Arya R, Wilson JA, Vannest J, Byars AW, Greiner HM, Buroker J, Fujiwara H, Mangano FT, Holland KD, Horn PS, Crone NE, Rose DF. Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation. Epilepsy Res. 2015 Feb;110:78–87. 74. Flinker A, Korzeniewska A, Shestyuk AY, Franaszczuk PJ, Dronkers NF, Knight RT, Crone NE. Redefining the role of Broca’s area. Proc Natl Acad Sci USA In Press. Inventions, Patents, Copyrights (pending, awarded) Not Applicable Extramural Sponsorship: Current Grants 02/01/2015–11/30/2019 Temporal-spatial mapping of cortical networks important for human cognition 1R01NS091139-01 Sponsor: NINDS Total Direct Costs: $1,093,750 PI: Crone, NE Effort: 18% 07/01/14-06/30/19

Multi-scale network dynamics of human upper limb movements: characterization and translation to neuroprosthetics 1R01NS088606-01 Sponsor: NINDS Total Direct Costs: $1,250,000 PI: Crone, NE Effort: 18%

05/01/10-04/30/15

Electrocorticographic Studies of Human Cortical Function 3R01NS40596-09 Sponsor: NINDS Total Direct Costs: $1,250,000 PI: Crone, NE Effort: 18%

07/01/11–06/30/16

The Biology of Human Cortical Pain Related Activity R01NS038493 Sponsor: NINDS Annual Direct Costs: $218,127 PI: Lenz, FA Effort: 5%

Pending Grants 06/01/15-05/31/20

Previous Grants 7/01/93-6/30/95

Microelectrode Studies of Dynamic Cortical Circuits Associated with Sensory Input Congressionally Directed Military Research Program Sponsor: Department of Defense Direct Cost: $992,233 PI: Andersen, Richard Effort: 10%

Human Cortical Electrical Correlates of Speech and Language Individual Grants-In-Aid for Research. Sponsor: The McDonnell-Pew Program in Cognitive Neuroscience Total Direct Costs: ~$30,000 PI: Crone, NE Effort: 100%

1/01/95-7/31/95

Cortical Electrical Correlates of Human Cognition The Passano Foundation Clinician Scientist Award Sponsor: Johns Hopkins University. Total Direct Costs: ~$30,000 PI: Crone, NE Effort: 75%

8/01/95-7/31/00

Cortical Electrical Correlates of Human Cognition NINDS Clinical Investigator Development Award K08 NS01921-01 Sponsor: NINDS Total Direct Costs: ~$404,750 PI: Crone, NE Effort: 75%

9/01/96-9/01/99

Investigation of Human Cortical Language Maps Using Complementary Functional Localization Techniques: Functional MRI, Cortical Electrical Stimulation, and Electrocorticographic Recordings Dana Clinical Hypotheses in Neuroscience Research Program Sponsor: The Charles A. Dana Foundation Total Direct Costs: $112,699 PI: Crone, NE Effort: 10%

4/01/01-1/31/03

A 20-week Double-Blind, Placebo-Controlled Crossover Study of the Efficacy and Safety of Donepezil for Memory and Other Cognitive Disturbances in Patients with Intractable Left Temporal Lobe Epilepsy Sponsor: Pfizer, Inc. Total Direct Costs: $100,000 PI: Crone, NE Effort: 5%

4/15/01-4/14/05

Electrocorticographic Studies of Human Cortical Function, 1R01NS40596-01A1 Sponsor: NINDS Total Direct Costs: ~$900,000 PI: Crone, NE Effort: 50%

7/01/02-3/31/07

Complex Sound Processing In The Human Temporal Lobe 3R01 DC005645 Sponsor: NIH Total Direct Cost: $1,040,000 PI: Boatman, D Role: Co-Investigator Effort: 1%

9/01/02-08/31/04

Quantitative Studies of Sturge-Weber Syndrome Supplement to NINDS 1R01NS40596-01A1 Sponsor: NINDS Total Direct Costs: $120,000 PI: Crone, NE Effort: 5%

4/01/05-3/31/10

The Biology of Human Cortical Pain Related Activity 2 RO1 NS038493 Sponsor: NINDS Total Direct Cost: $1,775,000 PI: Lenz, F Role: Co-investigator Effort: 5%

7/01/05-6/30/09

Electrocorticographic Studies of Human Cortical Function 2R01NS40596 Sponsor: NINDS Total Direct Costs: $920,000 PI: Crone, NE Effort: 50%

7/01/09-6/30/10

Electrocorticographic Studies of Human Cortical Function ARRA Supplement to 2R01NS40596 Sponsor: NINDS Total Direct Costs: $100,000 PI: Crone, NE Effort: 30%

10/01/10-04/30/12

Competitive Supplement to Electrocorticographic Studies of Human Cortical Function 3R01NS40596-09S1

Sponsor: NINDS Total Direct Costs: $1,050,000 PI: Crone, NE Effort: 15% Contracts (co-investigator in investigational drug trial) 10/01/91-05/31/93 DuP 996 (Alzheimer's Disease), DuPont/Merck. 02/01/94-12/31/00 E2020/Donepezil (Alzheimer’s Disease), Eisai America. 01/01/95-09/30/96 AF102B (Alzheimer's Disease), Forest Laboratories. 04/01/95-12/31/99 ENA 713 (Alzheimer’s Disease), Sandoz. 06/01/96-12/31/97 Milameline (Alzheimer's Disease), Warner-Lambert. 05/01/97-12/31/99 Lazabemide (Alzheimer's Disease), NINCDS/ADRDA; Protodigm. 09/01/97-12/31/99 Donepezil (Vascular dementia), Eisai America. 10/01/97-09/30/99 Pregabalin (Epilepsy), Pfizer. 12/01/97-12/31/98 Metrifonate (Alzheimer’s Disease), Bayer. 02/01/99-12/31/00 Donepezil (Mild Cognitive Impairment), Eisai/Pfizer. 09/01/99-09/30/02 Rufinamide (Epilepsy), Novartis Pharmaceuticals. Research Program Building / Leadership 4/15/2001- present

Director, Cognitive Neurophysiology Laboratory I am primarily responsible for funding, training, and supervising post-doctoral clinical and research fellows and graduate and undergraduate students engaged in research testing of patients with intracranial EEG, as well as in analysis and interpretation of intracranial EEG recordings. The results of these analyses are made available to clinical epileptologists to complement the routine functional maps from electrocortical stimulation. I also supervise 3-D reconstructions of neuroimaging data to visualize the locations of surgically implanted intracranial electrodes. The resulting images are also made available to neurologists and neurosurgeons for assistance in planning epilepsy surgery.

EDUCATIONAL ACTIVITIES Educational Publications Peer-reviewed original educational publications Not applicable Peer-reviewed publications (e.g. consensus statements, expert opinions) Not applicable Invited review articles 1. Lesser RP, Arroyo S, Crone N, and Gordon B. Motor and Sensory Mapping of the Frontal and Occipital Lobes. Epilepsia 1998;39:(Suppl. 4):S69-S80. 2. Crone NE, Sinai AS, and Korzeniewska A. High-frequency gamma oscillations and human brain mapping with electrocorticography. Progress in Brain Research, 2006;159:279-302. 3. Lesser RP, Crone NE, Webber WR. Subdural electrodes. Clinical Neurophysiology, 2010 Sep;121(9):137692. Review. PMC2962988 4. Lesser RP, Crone NE, Webber WR. Using subdural electrodes to assess the safety of resections. Epilepsy & Behavior, 2011 Feb;20(2):223-9. Epub 2010 Sep 29. Review. 4. Liu CC, Franaszczuk P, Crone NE, Jouny C, Lenz FA. Studies of properties of "Pain Networks" as predictors of targets of stimulation for treatment of pain. Front Integr Neurosci. 2011;5:80. Epub 2011 Dec 5. Free PMC Article

5. Crone NE, Korzeniewska A, Franaszczuk P. Cortical gamma responses: Searching high and low. International Journal of Psychophysiology 2011; 79(1):9-15. PMC3958992. (peer-reviewed) 6. Fifer MS, Acharya S, Benz HL, Mollazadeh M, Crone NE, Thakor NV. Toward electrocorticographic control of a dexterous upper limb prosthesis: building brain-machine interfaces. IEEE Pulse, 2012 Jan;3(1):38-42. PMC3987748 (peer-reviewed) 7. Lachaux JP, Axmacher N, Mormann F, Halgren E, Crone NE. High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research. Progress in Neurobiology, 2012 Jun 26;98(3):279-301. PMC3980670. (peer-reviewed) Editorials, Case Reports, Letters, Correspondence Not applicable Book Chapters and Monographs 1. Crone NE. Functional mapping with ECoG spectral analysis. In: Williamson PD, Siegel AM, Roberts DW, Thadani VM, Gazzaniga MS, eds. Neocortical Epilepsies. Advances in Neurology, Volume 84. Lippincott Williams & Wilkins, Philadelphia, 2000: 343-51. 2. Crone NE & Hao L. The functional significance of event-related spectral changes (ERD/ERS) from the perspective of electrocorticography. In: Reisin RC, Nuwer MR, Hallett M, Medina C, eds. Advances in Clinical Neurophysiology (Supplements to Clinical Neurophysiology), Volume 54. Elsevier Science, Amsterdam, 2002: 435-442. 3. Kaplan PW & Crone N. New-onset epilepsy: Emerging trends and strategies for improving outcomes. Advanced Studies in Medicine 2005;5(1B):S55-56. 4. Crone NE. Absence seizures. Current Therapy in Neurologic Disease, 7th Edition. Mosby Elsevier, Philadelphia, 2006: 30-33. 5. Crone, N.E., et al., ERD/ERS and ERPs, in Event-related potentials in patients with epilepsy: from current state to future prospects, A. Ikeda and Y. Inoue, Editors. 2008, Libbey: Montrouge. p. 233-246. 6. Crone, N.E., Korzeniewska, A., Ray, S., Franaszczuk P.J., Cortical function mapping with intracranial EEG, in Quantitative EEG analysis methods and application, S. Tong and N.V. Thakor, Editors. 2009, Artech House: Norwood, MA. p. 369-399. 7. Cervenka, M.C., Crone, N.E. Electrocorticographic spectral analysis, in Clinical Brain Mapping, D. Yoshor and E. Mizrahi, Editors. 2012, McGraw-Hill Medical: New York, NY. Books, Textbooks Not Applicable Other media (films, videos, CD-ROMs, slide sets, etc) Not Applicable Peer-reviewed Conference Proceedings 1. Crone NE, Hart J, Boatman D, Lesser RP, Gordon B. Regional cortical activation during language and related tasks identified by direct cortical electrical recording. Brain and Language 1994;47:466-468. 2. Boatman D, Crone N, Hart J, Lesser R, Gordon B. Interrelatedness of syllable perception and production: Evidence from direct cortical electrical interference and recording. Brain and Language 1995;51:188-191. 3. Ritaccio A, Brunner P, Cervenka MC, Crone N, Guger C, Leuthardt E, Oostenveld R, Stacey W, Schalk G. Proceedings of the First International Workshop on Advances in Electrocorticography. Epilepsy & Behavior, 2010 Nov;19(3):204-15. 4. Zhang H, Benz HL, Bezerianos A, Acharya S, Crone NE, Maybhate A, Zheng X, Thakor NV. Connectivity mapping of the human ECoG during a motor task with a time-varying dynamic Bayesian network. Conf Proc IEEE Eng Med Biol Soc, 2010(1):130-3. PMC4021587 5. Fifer MS, Mollazadeh M, Acharya S, Thakor NV, Crone NE, Asynchronous Decoding of Grasp Aperture from Human ECoG During a Reach-to-Grasp Task, Conf Proc IEEE Eng Med Biol Soc, 2011: 4584–4587. PMC3324943

6.

Ritaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J, Viventi J, Williams J, Schalk G. Proceedings of the Second International Workshop on Advances in Electrocorticography. Epilepsy Behav. 2011 Oct 27. 7. Ritaccio A, Beauchamp M, Bosman C, Brunner P, Chang E, Crone N, Gunduz A, Gupta D, Knight R, Leuthardt E, Litt B, Moran D, Ojemann J, Parvizi J, Ramsey N, Rieger J, Viventi J, Voytek B, Williams J, Schalk G. Proceedings of the third international workshop on advances in electrocorticography. Epilepsy and Behavior 2012 Dec;25(4):605-13. 8. Burns SP, Sritharan D, Jouny C, Bergey G, Crone N, Anderson WS, Sarma SV. A network analysis of the dynamics of seizures. Conf Proc IEEE Eng Med Biol Soc, 2012 Aug; 2012: 4684-7. PMID 23366973. 9. Benz HL, Collard M, Tsimpouris C, Acharya S, Crone NE, Thakor NV, Bezerianos A. Directed causality of the human electrocorticogram during dexterous movement. Conf Proc IEEE Eng Med Biol Soc, 2012 Aug 28-Sept 1: 1872-5. PMID 23366278. 10. Hotson G, Fifer MS, Acharya S, Anderson WS, Thakor NV, Crone NE. Electrocorticographic decoding of ipsilateral reach in the setting of contralateral arm weakness from a cortical lesion. Conf Proc IEEE Eng Med Biol Soc, 2012 Aug 28-Sept 1: 4104- 7. PMID23366830. 11. Ritaccio A, Brunner P, Crone NE, Gunduz A, Hirsch LJ, Kanwisher N, Litt B, Miller K, Moran D, Parvizi J, Ramsey N, Richner TJ, Tandon N, Williams J, Schalk G. Proceedings of the fourth international workshop on advances in electrocorticography. Epilepsy and Behavior 2013 Sep 10 [Epub ahead of print] 12. Burns SP, Sritharan D, Jouny C, Bergey G, Crone N, Anderson WS, Sarma SV. A network analysis of the dynamics of seizure. . Conf Proc IEEE Eng Med Biol Soc, 2012 Aug 28-Sept 1: 4684-7. PMID23366973. 13. Thakor, NV, Fifer MS, Hotson G, Benz HL, Newman GI, Milsap GW, Crone NE. “Neuroprosthetic Limb Control with Electrocorticography: Approaches and Challenges.” Conf Proc IEEE Eng Med Biol Soc 2014 (August 2014): 5212– 15. doi:10.1109/EMBC.2014.6944800.

Teaching: Classroom Instruction 1997 - 1999 “Topics in Neuroscience” for undergraduate students Topic: Language organization in the human brain Lecturer in annual lecture series at The Johns Hopkins University 1997 - 1998 Neurology/Neuropathology for medical students Topic: Language organization in the human brain Lecturer in annual lecture series at The Johns Hopkins University School of Medicine 2000 – present Neuroengineering Seminars and Lecture Series Topics: EEG studies of human cognition, Gamma oscillations and human brain function Lecturer 1-3 times per year in The Johns Hopkins University School of Medicine Clinical Instruction 1995- present “Neurology Residents’ Noon Lecture Series” Topics: Antiepileptic Drug Therapy, Cognitive aspects of epilepsy, Epilepsy Surgery Lecturer in annual lecture series, The Johns Hopkins Hospital 1995-present “Neurology Basic Clerkship” for medical students Topic: Classification of Seizures and Epilepsies Monthly lecturer, The Johns Hopkins University School of Medicine 1995-present Daily teaching rounds in video-EEG interpretation 1-2 months/year in JHH Epilepsy Monitoring Unit, Practical teaching to fellows, neurology residents, and medical students 1996-present “Clinical Neurophysiology Lecture Series” for clinical neurophysiology fellows Topics: Event-related desynchronization, Pre-surgical evaluation of cognition Lecturer in annual lecture series at The Johns Hopkins Hospital 1996-present EEG interpretation 1 afternoon every other week Practical teaching to fellows and neurology residents

CME Instruction 12/1994 “Clinical and Experimental Research Using Subdural Electrodes.” American Epilepsy Society Symposium: Subdural Monitoring in Epilepsy, Invited lecturer, New Orleans, LA 06/1995 “Alzheimer’s Disease and Memory Disorders.” The Johns Hopkins Medical and Surgical Association Biennial Meeting, Invited lecturer, Baltimore, MD 09/2000 “Mapping Somatomotor, Sensory, and Language Function.” Epilepsy 2000: Functional Imaging Symposium, Invited lecturer, Jefferson Medical College, Philadelphia, PA 11/2001 “The Management of Intractable Epilepsy.” Invited lecturer, Baltimore, MD. 10/2006 “Management of Refractory Epilepsy”, Provenzano Memorial Lecture, Department of Internal Medicine Grand Rounds, Invited lecturer, Inova Fairfax Hospital. 3/2007 “Management of Refractory Epilepsy.” Invited lecturer, Harford Memorial Hospital, Havre de Grace, MD. 4/6/2013 “Intractable Epilepsy”, Practical Update in Outpatient Neurology, Johns Hopkins Hospital, Baltimore, MD. Workshops/seminars Not applicable Mentoring: Advisees 1997-2001 2000-2002 2000-2004 2003-2008 2003-2007 2004-2006 2004-2010

2007-2009

2008-2011 2008-2012

2008-2014

Lei Hao, Ph.D., post-doctoral research fellow, currently Research Associate, Mind-Brain Institute, Johns Hopkins University, Baltimore, MD. Heidi Kirsch (formerly Majors), M.S., M.D., clinical neurophysiology/epilepsy fellow, currently Associate Professor of Neurology, UCSF, San Francisco, CA. Awarded Research Clinical Training Fellowship by Epilepsy Foundation of America(2001 – 2002). Christopher W. Bowers, DMD, bachelors and masters degrees in neuroscience (JHU), currently dentist in private practice, Brooklyn, NY. Awarded Howard Hughes Summer Research Fellowship (2002). Supratim Ray, Ph.D., graduate student in biomedical engineering (JHU), currently Assistant Professor, Centre for Neuroscience, Indian Institute of Science, Bangalore, India. Alon Sinai, Ph.D., post-doctoral research fellow in neurology (JHU), currently Head of the Department of Neurosurgery Research Lab, Rambam Health Care Campus, Haifa, Israel. Mohamad Koubeissi Mohamad Koubeissi, M.D., clinical neurophysiology/epilepsy fellow, currently Associate Professor of Neurology, George Washington University, Washington, DC. Awarded Epifellows Clinical Research Training Fellowship (2005) Anna Korzeniewska, Ph.D., post-doctoral research fellow in neurology (JHU), currently Research Associate, Department of Neurology, JHU SOM, Baltimore, MD. Awarded Post-Doctoral Research Training Fellowship from the Epilepsy Foundation (2008) and the Young Investigator Travel Award for a platform presentation from the American Epilepsy Society (2008) Susan J. Shaw, M.D., clinical neurophysiology/epilepsy fellow (JHU), currently Assistant Professor, Neurology, USC, Director of Epilepsy Service Line, Associate Director of Stroke Medical Home at Rancho Los Amigos Rehabilitation Center, Los Angeles, CA. Awarded Research and Training Fellowship for Clinicians by the Epilepsy Foundation (2008-2009). Soumyadipta Acharya, M.D., Ph.D., graduate student and junior faculty in biomedical engineering (JHU, co-advised with Dr. Thakor), currently Assistant Research Professor and Graduate Program Director, Department of Biomedical Engineering, JHU, Baltimore, MD. Adeen Flinker, Ph.D., graduate student in neuroscience (UC Berkeley, co-advised with Robert T. Knight), currently post-doctoral research fellow at NYU, New York, NY. Awarded Ruth L. Kirschstein National Research Service Award (2012) for post-doctoral fellowship research in collaboration with Dr. Crone. Heather Benz, graduate student in biomedical engineering (JHU, co-advised with Nitish Thakor), The Johns Hopkins University, Baltimore, MD. Selected as pen finalist for IEEE EMBS Student Paper Competition with travel stipend for meeting in Buenos Aires (2010) .

2008-2013 2009-2012 2009-present 2011-2012 2012-present 2011-present 2012-present 2011-present

Mackenzie Cervenka, M.D., post-doctoral clinical fellow and junior faculty, currently Assistant Professor of Neurology, JHU SOM, Baltimore, MD. Awarded Research and Training Fellowship for Clinicians by Epilepsy Foundation (2009-2010). Brian Pasley, Ph.D., post-doctoral research fellow (UC Berkeley, co-advised with Robert T. Knight), currently employed as researcher in private firm in Oakland, CA. Matt Fifer, graduate student in biomedical engineering (co-advised with Nitish Thakor), The Johns Hopkins University, Baltimore, MD. Akshay Krishnaswamy, undergraduate, currently employed as programmer in San Francisco, CA. Awarded Provost’s Undergraduate Research Award (Fall 2011). David McMullen, medical student at University of Medicine and Dentistry New Jersey, currently working in the Cognitive Neurophysiology Lab under Dr. Crone’s supervision, JHU SOM, Baltimore, MD. Awarded HHMI Medical Research Fellowship (2012-2013). Yujing Wang, masters student in biomedical engineering at JHU, then graduate student in bioengineering at University of Maryland, College Park, MD Griffin Milsap, graduate student in biomedical engineering (co-advised with Nitish Thakor), The Johns Hopkins University, Baltimore, MD Guy Hotson, graduate student in electrical engineering and computer science (co-advised with Nitish Thakor), The Johns Hopkins University, Baltimore, MD

Thesis committees 2002 Jeff Sieracki, Ph.D. in Applied Mathematics, University of Maryland, College Park, MD. Title: Greedy Adaptive Discrimination: Signal component analysis by simultaneous matching pursuits with application to ECoG signature detection. Role: co-advisor and dissertation committee member 2003-2004 Christopher W. Bowers, masters degree thesis in Neuroscience, The Johns Hopkins University, Baltimore, MD. Title: Event-related brain potentials (ERP) elicited by syntactic incongruities in language and music Role: advisor 2008-2009 Soumyadipta Acharya, Ph.D. in Biomedical Engineering, JHU, Baltimore, MD. Title: Deciphering the neural code of dexterous hand movements Role: co-advisor and dissertation committee member Training grant participation 5/1/2004-6/30/2014 Neuroengineering Training Initiative (NETI) T32EB003383 NIH/NIBIB PI: Nitish Thakor, Ph.D. Role: I co-advise graduate students in biomedical engineering on research projects utilizing electrocorticography for brain-computer and brain-machine interfaces. I also regularly give lectures at NETI seminars and assist in the recruitment of BME graduate students on behalf of the program. Educational Program Building/Leadership 7/01/2004-present

Associate Director, Clinical Neurophysiology/Epilepsy Fellowship Program Department of Neurology, JHU School of Medicine I am primarily responsible for the fellow candidate interview and selection process, for mentorship in research projects, clinical training, and career development of fellows, for coordination of in-service examinations and fellow evaluations, and for scheduling clinical and research rotations. In addition, I assist the Director of the Clinical Neurophysiology Fellowship, Dr. Ronald Lesser, in the documentation of compliance with ACGME regulations.

7/01/2007-present

Co-Director, Behavioral Neurology & Neuropsychiatry Fellowship Program Department of Psychiatry, JHU School of Medicine I assist the fellowship director, Dr. Vani Rao, in the fellow candidate interview and selection process, in fellow mentorship on research projects, clinical training, and career development, in evaluation of fellows, and in scheduling clinical and research rotations

Educational Extramural Funding (current, pending, previous) Not applicable CLINICAL ACTIVITIES Certification: Medical licensure 1991- present Maryland medical license #D41895 Boards, other specialty certification 1993American Board of Psychiatry and Neurology, Certification in Neurology #38589 1996American Board of Psychiatry and Neurology, Added Qualifications in Clinical Neurophysiology, Certificate #538 Clinical (Service) Responsibilities: Attending in Epilepsy Monitoring Unit 1-2 months per year Attending in Epilepsy Clinic once a week EEG interpretation one day every other week Co-supervision (with Jason Brandt, Ph.D.) of Wada tests, pre-op and post-op neuropsychological testing of epilepsy patients (weekly) Attending on Intraoperative Monitoring Service three days every two weeks Ad hoc intraoperative and extraoperative electrocortical stimulation mapping SYSTEM INNOVATION AND QUALITY IMPROVEMENT ACTIVITIES Not Applicable ORGANIZATIONAL ACTIVITIES Institutional Administrative Appointments 1996-1999 Member, JHU Department of Neurology Financial Planning Committee 2010-present Member, Kennedy-Krieger Institute, Kirby Protocol Review Committee Editorial Activities: Journal Reviewer (Ad hoc) 2002-2012 Clinical Neurophysiology, 2003-2011 Annals of Neurology 2003-2007 Epilepsia 2003-2007 Brain and Language 2003 JHU Press 2004 European Journal of Neuroscience 2004-2011 Neuroimage 2005 Journal of Neurophysiology 2005 Journal of Theoretical Biology 2005-2010 Human Brain Mapping 2005-2011 Cerebral Cortex 2006-2007 Brain

2006-2011 2007-2008 2008 2008 2009 2009-2010 2009-2011 2009-2012 2010 2010-2011 2011 2011 2012-present

Journal of Neuroscience Frontiers in Neuroscience Epilepsy Research Neuroscience Letters PLoS Computational Biology International Journal of Psychophysiology Journal of Cognitive Neuroscience PNAS Neuron Journal of Neuroengineering Epilepsy & Behavior Nature Journal of Clinical Neurophysiology

Advisory Committees, Review Groups/Study Sections 2003 NIH, NCRR Special Emphasis Panel, Technology Development for Biomedical Applications, 2/10/03 2003 National Science Foundation, Cognitive Neuroscience Program, ad hoc review, 6/9/03 2005 Austrian Science Fund, Department of Biological and Medical Sciences, 10/23/2005 2009 National Science Foundation, Cognitive Neuroscience Program, ad hoc review 2009 NIH, Neurotechnology Study Section, Ad hoc reviewer, 2009 Oct 5-6, 2010 Jun 10-11, 2011 Jun 10. 2011 AERES—Agence d’évaluation de la recherche et de l’enseignement supérieur (Evaluation Agency for Research and Higher Education), Committee member for site review of Brain Dynamics Institute, INSERM, CNRS, Universite Aix-Marseille, France, 2011 Feb 24-25. Professional Societies 1991- American Academy of Neurology 1993- American Clinical Neurophysiology Society 1994- American Epilepsy Society, Annual Course Committee (1999-2003), Scientific Program Committee (2004-2007) 2011- American Neurological Association, Fellow (2011) Conference Organizer, Session Chair 2002 International Organization of Psychophysics, Symposium Co-chair, “Event-related desynchronization/synchronization: a new tool to evaluate brain functions”, Montreal, CA 2003 American Academy of Neurology Annual Meeting, Scientific Program, Cognition and Behavior Platform Session Co-chair, Honolulu, HI, 2003 Advanced Studies in Medicine, CME Symposium Co-chair, “New Onset Epilepsy: Emerging Trends and Strategies in Pharmacotherapy”, Chicago, IL 2012 American Neurological Association Annual Meeting, Session Chair, “Continuous EEG: Pros and Cons”, Boston, MA. 2012- American Neurological Association, Luncheon Seminar Program Committee Consultantships 2006 National Guard Hospital, Riyahd, Saudi Arabia RECOGNITION Honors and Awards 1983 Zeke M. Buckner Writing Award, LSU-Shreveport 1983 Magna Cum Laude, LSU-Shreveport 1995 The Passano Foundation Clinician Scientist Award, The Johns Hopkins University 2001 The Mary A. Brazier Young Investigator Award for “Induced electrocorticographic gamma activity during auditory perception” in competition held by The International Federation of Clinical Neurophysiology

Invited Talks, Panels 09/09/93 "Electrocortical Correlates of Human Language.” Dedication of the A. Earl Walker Electrophysiology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 03/03/95 "ECoG Spectral Analysis: A New Technique for Functional Neuroimaging." JDRC Forum for MultiDisciplinary Research: Dialogue between Cognitive Science and Neuroscience”, Sapporo, Japan 01/17/98 “Modification of Ongoing Cerebral Rhythms by Cognitive Activity.” Electrophysiology of the Brain / A Symposium in Honor of Ernst Niedermeyer, Baltimore, MD. 09/24/98 “Functional Brain Mapping with Electrocorticographic Spectral Analysis.” Neocortical Epilepsy Symposium 1998, Dartmouth-Hitchcock Medical Center, Lebanon, NH 01/26/99 “Cognitive Neuroscience Investigations: Choice of Technique.” Winter Conference on Brain Research, Snowmass, CO 04/09/01 “Human Functional Brain Mapping with ECoG Spectral Analysis.” The Krasnow Institute Seminar Series, George Mason University, Fairfax, VA 04/13/01 “Human Functional Brain Mapping with ECoG Spectral Analysis.” Neurology Grand Rounds, Veterans Administration Hospital, Washington, DC 05/17/01 "Electrocorticographic studies of ERD/ERS." XV International Congress of Clinical Neurophysiology Symposium: Event-related synchronization / desynchronization and the brain computer interface, Buenos Aires, Argentina 05/09/02 "Human brain mapping with electrocorticographic spectral analysis." Department of Medical Physics, Warsaw University, Warsaw, Poland 05/14/02 "Functional mapping with electrocorticographic spectral analysis." Department of Medical Informatics, Institute of Biomedical Engineering, Graz, Austria 07/30/02 "Electrocorticographic studies of ERD/ERS." XI World Congress of Psychophysiology Symposium (co-chair): Event-related desynchronization/synchronization: a new tool to evaluate brain functions. Montreal, Canada 08/29/02 “Functional brain mapping with electrocorticographic spectral analysis.” Epilepsy Conference, Department of Neurology, Stanford University, Palo Alto, CA 08/30/02 “Functional brain mapping with electrocorticographic spectral analysis.” Epilepsy Conference, Department of Neurology, UCSF, San Francisco, CA 09/02/02 “Human brain mapping with ECoG spectral analysis.” Grand Rounds, Department of Neurology, Washington University, St. Louis, MO 10/07/02 “Electrocorticographic gamma activity during human cortical processing”, The David Bodian Seminar in Neuroscience, The Zanvyl Krieger Mind/Brain Institute, The Johns Hopkins University, Baltimore, MD 03/13/03 “Expanding your mind: Fascinating careers in Neuroscience & Cognitive Science”, Panel Discussion, University of Maryland Career Center, University of Maryland, College Park, MD 12/18/03 “Human brain mapping with electrocorticography”, Neuroscience Lecture Series, Center for Neuroscience and Behavioral Medicine, Children’s National Medical Center, Washington, DC 08/10/04 “EEG gamma activity and human brain mapping”, Hamburg University Neuroscience Seminar, Hamburg, Germany 04/13/04 “EEG gamma activity and human brain mapping”, Interdisciplinary Program in Neuroscience Seminar Series, Georgetown University, Washington, DC 10/02/04 “Electrocorticography: A window to human brain function”, Brain Days Symposium, University Medical Center, Utrecht, Netherlands 11/02/06 “Functional brain mapping with subdural electrocorticography”, Department of Neurology Grand Rounds, University of Chicago, Chicago, IL 11/03/06 “High frequency gamma oscillations and human brain mapping with electrocorticography”, High Frequency EEG Symposium (Chair: Jean Gotman, Ph.D.), American Clinical Neurophysiology Society Annual Meeting, Wyndham Chicago Hotel, Chicago, IL 12/02/06 “Electrocortical stimulation mapping and electrocorticography (ECoG)”, Investigators’ Workshop -Language localization in surgical planning: methods and controversies (Moderator: Paul Garcia, M.D.), American Epilepsy Society Meeting, San Diego, CA

10/13/07 10/17/07 12/07/07 12/14/07 03/31/08 03/17/08 06/13/08 11/10/08 12/09/08 12/09/08 04/25/09 08/07/09 12/02/09 01/21/10 01/22/10 04/06/10 06/20/10 10/06/10 11/11/10 06/03/11 06/14/11 11/11/11 9/14/12 10/11/12 3/23/13 7/9/13 7/17/13

“ERD/ERS and ERPs”, International Workshop on Event-Related Potentials in Patients with Epilepsy, Hotel Okura Kyoto, Kyoto, Japan “Electrocorticographic gamma activity and functional brain mapping in pre-surgical patients”, Clinical Neuroscience Seminar, UCSF, San Francisco, CA “Event-related gamma activity in ECoG”, Large-Scale Brain Dynamics Workshop, Neural Information Processing Systems (NIPS) Conference, Whistler, British Columbia, Canada “Electrocorticographic gamma activity and human brain mapping”, Neuroscience Institute Seminar, Swedish Medical Center, Seattle, WA “Gamma oscillations and human cortical function: Perspectives from invasive EEG”, Epilepsy Grand Rounds, Case Western Reserve University, Cleveland, OH. “Gamma oscillations and functional brain mapping in the surgical management of epilepsy”, Epilepsy Research Seminar, Neurological Institute, Columbia-Presbyterian, New York, NY “Mapping Language in the Brain”, Brain Science Institute 2008 Spring Symposium on Neuroscience and Cognition, Johns Hopkins University, Baltimore, MD “ECoG spectral mapping”, ECoG Workshop UC Berkeley, CA “Mapping parietal lobe function” Neuropsychology Special Interest Group, American Epilepsy Society, Seattle, WA “ECoG Studies of Human Cortical Function” ECoG Workshop, American Epilepsy Society in Seattle, WA “Functional brain mapping in epilepsy surgery”, Visiting Professor Lecture at Saudi National Guard Hospital, Riyadh, Saudi Arabia “Functional brain mapping in epilepsy surgery: Perspectives from intracranial EEG”, Neurosurgery Research Lecture Series, University of Iowa, Iowa City, IA “History and basics of ECoG recordings”, BCI2000 Workshop and International Workshop on Advances in Electrocorticography, The Sagamore, Bolton Landing, NY “Neural correlates of electrocorticographic oscillations”, Keynote lecture, Neurophysiology in Epilepsy Surgery Symposium, Epilepsy Surgery Society of Japan, Osaka, Japan "Functional brain mapping using intracranial electrodes before epilepsy surgery", Joint educational course of ESSJ and the Japan Society for Stereotactic and Functional Neurosurgery, Osaka, Japan “High frequency EEG activity and human cortical function: perspectives from intracranial recordings”, Weekly Neuroscience Lectures, Barrow Neurological Institute, Phoenix, AZ “ECoG studies of human cortical function”, Beyond Brain Machine Interface Workshop: From Senses to Cognition, IEEE EMBS, Long Beach, CA “Functional mapping with ECoG spectra”, 19th International Cleveland Clinic Epilepsy Symposia, Epilepsy Surgery: Invasive Evaluation, Cleveland, OH “Functional mapping with ECoG”, 2nd International Workshop on Advances in Electrocorticography, Society for Neuroscience, San Diego, CA “HFOs and stimulation: Are they redundant or complementary?”, High Frequency Oscillations in Cognition and Epilepsy Symposium at Montreal Neurological Institute, Quebec, Canada “Do cortical gamma responses reflect cognitive-motor information encoding of fine motor tasks?”, Special Session on Brain-Machine Interfaces For Dexterous Movement Control, 15th International Graphonomics Society Conference, Cancun, Mexico “Fundamentals of ECoG Functional Mapping", 3rd International Workshop on Advances in Electrocorticography, Society for Neuroscience, Washington, DC “Oscillatory activity in the EEG and even-related spectral perturbations”, Everything-but-ERP Nano Boot Camp, Kennedy-Krieger Institute, Baltimore, MD “Functional mapping using ECoG recordings”, 4th International Workshop on Advances in Electrocorticography, Society for Neuroscience, New Orleans, LA “Electrocorticography: Watching the human brain at work from within”, Annual Dartmouth Epilepsy Symposium, Stowe, VT "Functional Mapping in Epilepsy Surgery", George Washington Epilepsy Grand Rounds, Washington, DC “Neurological and surgical approaches in intractable epilepsy”, Department of Neurological Sciences, Kyoto University, Kyoto, Japan

7/19/13 10/9/13 2/20/14 6/12/14 6/13/14 1/15/15 1/17/15

“Epilepsy and Oscillations”, Okazaki Conference Center, National Institute of Physiological Sciences, Okazaki, Japan "Functional Mapping in Epilepsy Surgery", Cincinnati Children's Hospital Medical Center, Cincinnati, OH "Listening In on the Human Brain at Work", Keynote Speaker, February Fourier Talks, University of Maryland, College Park, MD "Epilepsy Network", Korean Epilepsy Congress, Seoul, Korea "High Frequency Activity and Cognition", Korean Epilepsy Congress, Seoul, Korea “Mapping the functional dynamics of human brain”, Luncheon Seminar, Japanese Epilepsy Surgery Society, Tokyo, Japan “Functional Mapping in Epilepsy Surgery”, Special Lecture, Tohoku Epilepsy Forum, Sendai, Japan