CURRICULUM VITAE SILVESTRI Marc Registry Office Born : 13.06.1957 in Marseille (France) Nationality : French Office Adress : 10 boulevard Latil 13008 MARSEILLE – FRANCE Tél :

+ 33 ( 0)4.91.83 87 85

Mobile : + 33 (0)6 09 53 96 06 Fax :

+ 33 ( 0)4.91.75 72 09

E-mail : [email protected] [email protected] Internet site : www.cardiovista.fr

Degrees 1975

BACCALAUREAT série D

1982

Interne of hospital of Marseille .

1984

National Army Service : – Hospital La Meynard ,cardiology department

– (Dr Donatien), Fort de France (Martinique,France) 1984

Thesis MD Primary Angioplasty during Acute Myocardial Infarction

1988

Assistant of University Hospital of Marseille – Pr. Gérard. Chief of interventionnal cardiology department ( University of Marseille) Member of French Society of Cardiology (Interventionnal working group)

1986 –1990 : Fellowship of Interventionnal Cardiology: 1

Hospital TIMONE (Marseille-France) Pr Serradimigi Cardiologic Hospital CANTINI (Marseille-France) Pr Gérard

1988

Angioplasty course - Dr. Stertzer – San Francisco – USA.

1989

Angioplasty course - Dr. Hartzler – Kansas City – USA

1990 to 2000 : Private activity :Private hospital les Alpilles and

Beauregard (Marseille,France) angioplasty annually.

– 500 coronarography and 400

1996

Speaker congress : Revascularisation after bypass. – Pr. Virot – Limoges(France) – 3 et 4/10/1996.

1997

Speaker at 2 international meeting on interventional Cardiology - June 30 – July 3, 1997 – Jerusalem – Israel.

1998

Speaker at XII Practical Course in interventional Cardiology – Pr. Delcan - Madrid - Spain - 8 to 10.07.1998

1998

Speaker at 4 rencontres de Cardiologie Interventionnelle de l’Océan Indien – 27 / 28.11.1998 – la Réunion island(France)

1998

Speaker at American Heart association – Dallas – USA. Abstract:Unprotected left main stenting

1998

Speaker at the European Society of Cardiology, Stockholm (August 1998) Unprotected left main stenting

1999

Speaker at Indo-French endovascular Workshop – Pr. Cribier – Rouen (France) – 4 / 5 March 1999.

1999

Live case opérator and speaker at First World congress of international Cardiology – Bombay – India – 13 to 16.10.1999.

1999

Speaker to the Interventionnal Cardiology meeting , Prague(Tcheck Republic) – – Avril 1999, Dr Zelisko

1999

Speaker : High Tech Cardio 1999 – Marseille (France) –- January 1999.

2000

Speaker: Interventional Cardiology 2000, an international symposium Dr. Margolis – February 28 – March 3 - Aspen – USA

nd

ème

1996 – 2000 5 humanitarian missions– Erevan – Arménia. – Training for two arménian cardiologists 2000

Taking part to Third Indo-French endovasculaire Workshop - Pr. Cribier. 2

– Hyderabad – India – 11.2000. 2001

Taking part to High Tech Cardio 2001 – Marseille (France) –- 25, 27 January 2001.

2001

Speaker: 3rd international congress on complications during coronary intervention : management and prevention. –- June 27 - 30, 2001. - Lausanne (Switzerland).

2001

Speaker and live case demonstration au 4th Meeting of the Indo French Foundation for Interventional Cardiology . th th - November 8 – 9 , 2001 - Rouen (France)

2002

Speaker congress High Tech Cardio 2002 ,Marseille, France 24,25,26 january,2002

2002

Speaker and live case at congress « Journées Franco-Libanaises de revascularisation » Beyrouth( LEBANON ) 17.18.19. April 2002.

2002

Speaker to the French Society of Cardiology « Left main angioplasty » Montpellier, France 07.June, 2002.

2002

Speaker congress « Vascular Interventions » Mauritius ,10th – 15th August Unprotected Left Main Interventions

2002

European society of cardiology congress, Berlin 3rd September The French registry of left main coronary artery treatment. Abstract 2678

2002

5th Indo-French Foundation Interventional Cardiology meeting Live case operator / speaker (Madras,India) 24 – 27th October 2002

2002

The 7 International symposium on interventional cardiology and live demonstration course.(Speaker) 7 - 10 November 2002 Beijing – China.

2002

American Heart Association The French registry of left Main Coronary Treatment preliminary results 17, 20 November 2002 CHICAGO USA.

2002

Actualisations et Perspectives de la Pathologie Cardiovasculaire (APPAC) Speaker / Chairman Biarritz(France) 29, 30.11 et 01.12.2002

2003

Speaker congress: High Tech Cardio 2003 29/30/31 January 2003 “Unprotected left main french registry”

2003

Speaker : » Rencontres cardiologiques des Domes » Nouveautés en cardiologie :mythes ou réalités « Les stents actifs :La chirurgie coronaire va-t-elle disparaître ? » Clermont-Ferrand (France) 15/3/2003

2003

Speaker and chairman to the Unprotected left main meeting (Dr. Gershlick)

th

3

Leicester (England) june 9, 2003 th

2003

European Society of Cardiology Congress, Vienna, sept.5 The french registry of unprotected left main treatment Abstract

2003

American Heart Association ,Orlando ,November 11 The french registry of unprotected left main treatment Abstract 2755

2004

High Tech meeting, Marseille(France),29/31 jan Speaker and chairman

th

th

nd

Speaker and chairman:Vascular Interventions meeting; Cairo ,oct 30 -nov 2

Speaker and live case operator :International Summit on coronary artery desease and th cardiovascular Interventions ,18/20 February 2005,Renaissance Hotel,Mumbaï,India. 2005 th

Cardiology Summit 2004,Mumbai(India).Feb 13-15 ,speaker and live case

Speaker at TCT Asia,Séoul (Koréa) 27/30 april :Unprotected left main stenting with Taxus

Européan Bifurcation Club, 1 st meeting, Bordeaux (France),september 15-16 Speaker: Debate: Distal left main lésions:Should we treat it ?

2006 :

th

Speaker to the 7 annual conference of the Indian College of interventionnal Cardiology th st 26 february-1 march.On board Cruise liner “Super Star Virgo” (Singapore)

2006 : left main

Speaker at TCT Asia,Séoul (Koréa) 27 april : French registry of Unprotected stenting with Taxus

2006:

Speaker and live case to the 2nd international conference on newer frontiers in cardiology. 28th-30th sept,2006.Bombay hospital,Mumbai,India

2007: stenting with

- Speaker at TCT Asia,Séoul (Koréa) 24/27 april : Unprotected left main Taxus.Mid term follow up - Speaker and case presenter at 1St Left Main Summit ,august 24-25,2007,Jeju

island,Koréa 4

- Speaker at the “9th Francophone meeting”;Paris october 10th: Use and outcome of Titan-NO bio-active stents in daily practice :the TITAIX registry -Taïwan Transcatheter Therapeutics Live Course 2007: Speaker: Overview of Titan bioactive coronary stent data

Left Main PCI updates : what is left to the surgeon ?

2005 2008 Speaker and live case to the 5thSAARC congress of cardiology th th and 8 Sri Lanka heart association scientific sessions in Colombo (Sri Lanka) from 29 february to nd 2 march

Speaker and live cases to ADVANCED CARDIOVASCULAR THERAPEUTICS ,Madras Medical Mission,Chennai, 27-29th june Faculty and speaker at 2nd Indo-Européan Course on Revascularization (IECR 2008) 20-21 december,2008 New Delhi,India 2009 International faculty, Speaker and live case demonstrator at ADVANCED CARDIOVASCULAR THERAPEUTICS,17-19th july, at Madras Medical Mission hospital, India Speaker and live case at 61st annual conference of the Cardiological Society of India.3 -6th December. Kochi, Kerala, India: 3 vessel desease revascularization:lessons from Syntax and Fame trials rd

2010 International faculty, Speaker and live case demonstrator at ADVANCED CARDIOVASCULAR THERAPEUTICS,18-20th june, at Madras Medical Mission hospital, India -Multivessel PCI in diabetic patients - Left Main stenting: How I do it ?

2011 International faculty,speaker and live case operator at INDIA LIVE(National course on percutaneous cardio-vascular interventions Feb 18-20, 2011; Hotel Taj Lands End ,Bombay,India LMCA, strategies to interventional approach

5

2011: EXCEL trial investigator (Xience versus bypass surgery for unprotected left main desease)

From January 2001 to october ,2nd 2011 ,Interventionnal Cardiology activity in Marseille and in Aix en Provence (France) in private hospital PARC RAMBOT .Performing actually around 400 angioplasty and 500 coronary angiography / year From October 3rd,2011,interventional cardiologist in Clinique AXIUM,Aix en Provence (France)

Marseille ,20 december 2011

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PUBLICATIONS: -M.Silvestri, P.Villain, J.L Bouvier, A.Elias, M.Benichou, A.Serradimigni: L’anevrysme veineux poplité:une cause rare d’embolie pulmonaire. La presse médicale,12 decembre 1987,16,n°42 - J.Durand- Gasselin, D.Di Stefano, M.Silvestri, J.M Sainty : Myocardial infarction complicating therapeutic embolization of broncheal and diaphragmatic arteries . Réan.Soins intens.Méd.Urg., 1988,4,n°5,233-235 - P.Barragan, J.Sainsous, M.Silvestri, J.L Bouvier, B.Comet, J.B Siméoni, P.Villain, P.Pietri, J.M Quatre et G.Bayet. A pilot study of the eficaccy of ticlopidine in the early patency of coronary stents. Arch Mal Coeur 1994;87:1431-7 - A.F Chaix, P.Barragan, M.Silvestri et Al : Rotablator and stent procedure in left main coronary desease : Arch.Mal Coeur 1995;88 : 95-7 -Barragan P, Sainsous J, Silvestri M, Bouvier JL, Comet B, Simeoni JB, Charmasson C, Bremondy M. Ticlopidine and subcutaneous heparin as an alternative regimen following coronary stenting. Cathet Cardiovasc Diagn. 1995;32:133 - J.Sainsous, M.Silvestri,G.Bayet: Coronary arery stenting without anticoagulation,intravascular ultrasound or high pressure balloon:immediate results and one month follow up Circulation vol 94,n°8,october15,1996 (abstract) - M.Silvestri, P.Parikh,P.O Roquebert,P.Barragan, J.L Bouvier,B.Comet: Retrogade left main stenting,Catheterization and Cardiovascul.Diagnosis 39:396-399(1996) - P.Barragan,J.Sainsous,M.Silvestri and al: Coronary artery stenting without anticoagulation,aspirin,ultrasoud guidance or high balloon pressure: prospective study of 1051 consecutive patients Catheterization and cardiovascular diagnosis 42:367-373 (1997) -P.Barragan,R.Rieu,V.Garitey,P.O Roquebert,J.Sainsous,M.Silvestri,G.Bayet: Elastic recoil of coronary stents Catheterization and cardiovascular interventions 50:112-119 (2000) -Marc Silvestri, MD, Paul Barragan, MD, Joël Sainsous, MD, Gilles Bayet, MD, Jean-Baptiste Simeoni, MD, Pierre-Olivier Roquebert, MD, Gilles Macaluso, MD, Jean-Louis Bouvier, MD and Bertrand Comet, MD : Unprotected left main coronary artery stenting: immediate and medium- term outcomes of 140 elective procedures. J Am Coll Cardiol, 2000; 35:1543-1550 - V.Poyen,P.Labrunie,M.Silvestri, B.Valeix :Complete revascularization of multivessel coornary artery desease during acute myocardial infarction Arch Mal Coeur,tome 96,n°12,december 2003 7

-Didier Carié,Hélène Eltchaninoff,Thierry Lefèvre,Marc Silvestri et Al for the FRIEND investigators: Twelve month clinical and angiographic outcome after stenting of unprotected left main coronary artery stenosis with paclitaxel-eluting stents-results of the multicentre FRIEND regsistry. Eurointervention.2008;4:449-456 -Beatriz Vaquerizo MD, Thierry Lefèvre MD*, Olivier Darremont MD, Marc Silvestri MD, Yves Louvard MD, Jean Louis Leymarie MD, Philippe Garot MD, Helen Routledge MD, Federico de Marco MD, Thierry Unterseeh MD, Marcel Zwahlen PhD, and Marie-Claude Morice MD Unprotected Left Main Stenting in the Real World. Two-Year Outcomes of the French Left Main Taxus Registry. Circulation. 2009;119:2349-2356

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