C i l Curriculum vitae it Kai Kaarniranta 15 3 2011 15.3.2011

• • • • •

Kai Kaarniranta, professor, chief physician, MD., PhD., MSc Institute of Clinical Medicine-Ophthalmology Department of Ophthalmology; School of Medicine, University of Eastern Finland P.O.BOX 1627, 70211 Kuopio, Finland; Email: [email protected] Tel: +358-440-593290; Fax: +358-17-172486

• Curriculum vitae • • •

Name (ID) Place of birth: Savonlinna, Savonlinna Finland Marital Status: Married, two children

• •

PRESENT POSITION Specialist of Ophthalmology, Department of Ophthalmology, Kuopio University Hospital, P.O.BOX 1777, 70211 Kuopio, Finland 20.11.2006-Present Professor and Chairman, Chief Physician, Department of Ophthalmology, University of Kuopio and University Hospital, P.O.Box 1777, 70210 Kuopio, Finland 1.1.2008-Present

•

EDUCATION • Institution Degree • Senior S i S Secondary d S School h l Savonlinna College matriculation exam University of Kuopio MSc(Biotechnology) University of Kuopio MD p PhD ((Medicine)) Universityy of Kuopio • University of Kuopio Docent (Experimental p gy) Ophthalmology) • University of Kuopio Specialist in Ophthalmology University of Kuopio Docent (Ophthalmology)

Year 1990 1990 2000 2000 2002 2006 2006 2009

• THESIS • Kaarniranta K. Regulatory Differences of the hsp70 Gene Response p in Mammalian Cells. Doctoral dissertation. 2002. Kuopio University Publications D. Medical Sciences 274.81 • COMMAND OF LANGUAGES • Maturity paper written in Finnish, University of Kuopio, 2000 Certificate of oral and written knowledge of Swedish, Swedish 1994 English, 1994 • TEACHING ACTIVITIES • Teachingg in Anatomy y 1994-2004,, Department p of Anatomy, y, University of Kuopio Teaching in Ophthalmology 2004-Present , Department of Ophthalmology, University of Kuopio

SUPERVISING • • • • • • • • • • • • •

X MSc, thesis work, University of Kuopio 2006Y MD student, t d t th thesis i work, k U University i it off Kuopio K i 20072007 Z, thesis work, University of Kuopio, 2007A MD A, MD, thesis work work, Universityty of Kuopio, Kuopio 20072007 B, MSc, thesis work, University of Helsinki, 2008C MD, C, MD thesis work work, University of Kuopio 20082008 D, thesis work, University of Kuopio 2008E thesis work E, work, University of Eastern Finland 2010 2010F MSc, thesis work, University of Eastern Finland 2010K MSc, pro gradu, University of Kuopio 2005 L MSc, pro gradu, University of Kuopio, 2007 M,, MSc pro p gradu, g , Universityy of Kuopio p 2008 N MD, PhD thesis, University of Eastern Finland 2010

PROFESSIONAL APPOINTMENTS • Finnish Academy Graduate School, Department of Anatomy, University of Kuopio 1.1.2005-31.8.2000). • Juankoski Health Center, Juankoski, Finland (1.9.200031.5.2001; 1.8.-12.8.2001; 17.10- 23.10.2001); General Practioner • Department of Ophthalmology, North Karelia Central Hospital, Joensuu, Finland (5.11.2001 (5.11.2001- 30.4.2003); Residential Ophtalmologist, • Department of Ophthalmology, Kuopio University Hospital (14 4 2003 19 11 2006) Residential (14.4.2003-19.11.2006); id i l Ophthalmologist O hh l l i • Department of Ophthalmology, Kuopio University Hospital (20 11 2006 31 12 2007); Specialist of Ophtalmology (20.11.2006-31.12.2007); • Department of Ophthalmology, Kuopio University Hospital ((1.1.2008-Present); . . 008 ese ); Chief C e Physician ys c • Department of Ophthalmology, University of Kuopio (1.1.2008-Present); Professor, Chairman

AWARDS • Marttii Hämäläinen l i Young Scientists S i i 2003 • Kuopio University Scientist Award 2006 • Second S dP Poster t P Prize i NOK 2006 • SOE-lecture 2007 • Elsmay El Björn Bjö Young Y Scientist S i ti t Award A d 2009

LECTURES • 15th International Retina World Congress, Congress Helsinki, Helsinki 2008-072008 07 12 • European p Association of Vision and Eye y Research (EVER), ( ), Portoroz, Slovenia 2008 (lecture, organization and SIS chairman) • Tampereen T lääketiedepäivät, lääk ti d äi ät Tampere T 2009 • European Association of Vision and Eye Research (EVER), Portoroz Slovenia 2009 (lecture Portoroz, (lecture, organization and SIS chairman) • Baltic Forum, Vilnius, Litvinia 2010

INVITED REVIEWER • J Sport Science Medicine, Pathophysiology, J Diabetes Complicates, Brain research, Annals of Medicine, European Journal of Pharmacolical Sciences, Acta Zoologica Sinica, M di l Science Medical S i Monitor, M i Acta A O Ophthalmologica, h h l l i BMC ophthalmology, Molecular Biology of the Cell, Duodecim, I Investigative ti ti Ophthalmology O hth l l Vi Vision i Sciences, S i American A i Journal of Physiology, Recent Patents on DNA & Gene Sequence Journal of Biomedicine and Biotechnology Sequence, Biotechnology, FEBS Journal, Clinical Ophthalmology

GRANTS • • • •

Finnish Eye Foundation 40 000 eur (2007), post-doc Fi i h Eye Finnish E Foundation F d ti 10 000 eur (2008) (2008), post-doc td EVO 14 000 eur (2008) Finnish Funding Agency for Technology and Innovation 345 000 eur (2004-2006) • Finnish Funding Agency for Technology and Innovation 630 000 eur (2008-2011) • Päivikki and Sakari Sohlberg Foundation 75 000 eur (2009) • Academy of Finland 300 000 eur (2011 (2011-2013) 2013)

MEMBERSHIPS IN SCIENTIFICAL SOCIETIES • Secretary of Finnish Ophthalmology Society 2006-2007 • European Leadership Development Programme (EuLDP) 2007-2009 • Board of Directors Acta Ophthalmologica 2009• Editorial Frontiers in Biosciences 2010-

OTHER ACADEMICAL ACTIVITIES • Opponent for Anu Vaajanen thesis, 2009 • Reviewer for Marjo Volotinen thesis, 2009 • Opponent for Elisa Vuori-Heikkilä

LIST OF PUBLICATIONS 1. Articles in international journals using peer review 1 Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic 1. pressure coincides with mRNA stabilization rather than transcriptional activation. Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, H l i Helminen HJ. HJ Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2319-24. 2. Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium. Alastalo TP, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. Exp Cell Res. 1998 Apr 10;240(1):16-27. 3. Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature. temperature Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. FEBS Lett. 2000 Jun 23;475(3):283-6. . . . .

2. Articles in international scientific books, and in i international i proceedings i using i peer review i 1. Parkkinen JJ, Lammi MJ, Jortikka MO, Inkinen RI, Kaarniranta K., He1minen HJ Tammi MI. HJ, MI Cytoskeleton and Proteog1ycan synthesis in chondrocytes under hydrostatic pressure. (1999) In Osteoarthritis: Diagnosis, Treatment and Prevention, p. 21-34. Ed. Tanaka S. et a1., eds. Springer-Verlag, Tokio. 2 Lammi 2. L i MJ, MJ Sironen Si R, R Elo El M, M Oksala Ok l N, N Kaarniranta K i t K, K Karjalainen K j l i HM, HM Helminen HJ. Responses of mammalian cells to mechanical forces. (2001) In Recent Research Developments in Biophysics and Biochemistry, p. 77-98 eds. Research Signpost, India. 3. Törrönen K, Yaba1 M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. y stimulates keratinocyte y migration g and activates the transcription p factor Hyaluronan AP-I in keratinocytes through the JNK pathway. (2002) In: Hyaluronan. Chemical, Biochemical and Biological Aspects. ED. Kennedy JF et al. Vol. 1. p. 551-556 eds. Cambridge: Woodhead. Woodhead

3. Articles in domestic journals using peer review 1. Kaarniranta K, OksalaN, Lammi MJ, Helminen HJ, Sistonen L. Stressitutkimuksesta kliinisiin läpimurtoihin? [From research of cellular stress to various clinical break through i innovations?] ti ?] (2001) Duodecim: D d i 117, 117 2266-2272. 2266 2272 2. Kaarniranta K, Sihvola R, Salminen A, Lammi MJ, Teräsvirta Markku, Kontkanen M. Silmänpohjan ikärappeuma -vaikea ongelma sekä potilaalle etta silmälääkärille [Age related macular degeneration -a difficult problem both to the patient and the opthalmologist] (2003) Duodecim: 10, 935-942. pp uudet lääkkeet. Duodecim 3. Mannermaa E,, Urtti A,, Kaarniranta K. Nesteisen ikärappeuman (2007): 123:2229-2237.

Account for University or Hospital position/portfolio: • • • • • • • • • •

Impact of research/teaching Theme example: Aging Eye Research Programme: From Genes to Clinical Applications Background of research/teaching Created collaboration networks Th most important The i funding f di Research/teaching group Memberships in scientifical/educational societies I Impact t off research h – teaching t hi (portfolio) ( tf li ) Impact of clinical work - clinical experiences Future aspects