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Scientific Paper

University Department of Neurology, Sarajevo University Clinical Center, Sarajevo, Bosnia and Herzegovina Vuk Vrhovac Institute, University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Dugi dol 4a, HR-10000 Zagreb, Croatia Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina Institute of Hemodialysis, Sarajevo University Clinical Center, Sarajevo, Bosnia and Herzegovina

CORRELATION BETWEEN EARLY AND LATE EPILEPTIC SEIZURES AND DIABETES MELLITUS DURING AND AFTER STROKE Azra Alajbegoviæ1, @eljko Metelko2, Salem Alajbegoviæ3, D‘elaludin Kantard‘iæ1, Milan Bratiæ1, E. Suljiæ1, M. Hrnjica1, Halima Resiæ4

Key words: diabetes mellitus, epileptic seizures, stroke

SUMMARY Diabetes mellitus is a well-known risk factor for cerebrovascular diseases, but not so well-known for determining early and late epileptic seizures during and after stroke. Early and late epileptic fits recorded at the University Department of Neurology in Sarajevo during a 10-year period (from January 1, 1989 until December 31, 1998) in 7001 stroke patients were retrospectively evaluated so as to determine the impact of diabetes on the onset of stroke and of the early and late epileptic seizures. Out of 114 patients with epileptic seizures, 34 (29.8%) had diabetes mellitus (7.9% type 1 and 20.2% type 2). The mean age of patients was 60.0 years, with standard deviation of 12.52 years. The mean duration of diabetes was 10 years in patients with late seizures, and 14.7 years in patients with early fits. In the group of patients with early seizures, there were 19 patients with diabetes mellitus (3 patients with type 1 and 12 patients with type 2). In the group with late fits, there were 15 diabetics (3 patients with type 1 and 11 patients with type 2). Hyperglycemia was significantly more common in the group of patients with early fits than in the group with late fits (60.9%). The most frequent type of epileptic manifestations were partial seizures with secondary generalization. Diabetes mellitus was found to be a significant risk factor for the onset of stroke as well as for the occurrence of early epileptic seizures during stroke (p