Basel Seminars in Pathology Paediatric Pathology & Genetics June 22nd – 25th, 2016 Institute of Pathology, University Hospital Basel

Introduction The Basel Seminars in Pathology were established in 2010 to provide an update on diagnostic issues of our rapidly evolving discipline. Rotating across specialties over the years, the 2016 Basel Seminars in Pathology are devoted to Paediatric Pathology and Genetics, in reflection of their close interrelation. The Basel Seminar proper on the Friday and Saturday is designed to address the needs of the general pathologist for everyday problems with a special touch-up on frontiers in molecular diagnostics focusing on young patients. The Pre-Seminar Workshops on Thursday and Wednesday provide specialized training opportunities on selected topics in paediatric pathology and laboratory procedures of motility diagnostics. Elisabeth Bruder

Isabel Filges

Sylvia Hoeller

Basel Seminars in Pathology – Paediatric Pathology and Genetics Friday June 24th, 2016 08.00h – 09.00h Welcome Coffee and Registration 09.00h – 09.10h Elisabeth Bruder, Basel Isabel Filges, Basel Sylvia Hoeller, Basel

Introduction

09.10h – 09.55h Pierre Russo, Philadelphia

Systematic Approach to Paediatric Gastrointestinal Biopsies

09.55h – 10.40h Han van Krieken, Nijmegen

Polyps in the Gut in the Young and Old: What is New?

10.40h – 11.10h Coffee Break 11.10h – 11.55h Luc Oligny, Montreal

Epigenetics in Embryology and Oncology

11.55h – 12.40h Ray Redline, Cleveland

Clues to Pathology Diagnosis in Abortion

12.40h – 14.00h Lunch Break 14.00h – 14.45h Ivo Leuschner, Kiel

Differential Diagnosis of Paediatric Small Blue Round Cell Tumours – an Update

14.45h – 15.30h Raoul Hennekam, Amsterdam

Next Gen Sequencing Demands Next Gen Phenotyping

15.30h – 16.00h Coffee Break 16.00h – 16.45h Ronald de Krijger, Rotterdam

Differential Diagnosis of Congenital Tumours

16.45h – 17.30h Rita Alaggio, Padova

Lipomatous Tumours in Young Patients

Basel Seminars in Pathology – Paediatric Pathology and Genetics Saturday June 25th, 2016 08.30h – 09.15h Ivo Leuschner, Kiel

Spindle Cell Tumours (and Pseudotumours) of Soft Tissue – Differential Diagnosis

09.15h – 10.00h Luc Oligny, Montreal

Spectrum of Ciliopathies in Everyday Pathology

10.00h – 10.45h Ray Redline, Cleveland

Placenta Investigation: Patterns and Clinical Outcomes

10.45h – 11.30h Break 11.30h – 12.15h Pierre Russo, Philadelphia 12.15h – 13.00h Raoul Hennekam, Amsterdam

Inflammatory and Metabolic Disorders Involving the Gastrointestinal Tract in in Young Patients All in our Genes? From Foetal Nonsense to Adult Neoplasia

13.00h – 13.45h Antonio Torrelo, Madrid Skin Lesions Common to Childhood Isabel Colmenero, Madrid 13.45h – 13.50h Elisabeth Bruder, Basel Isabel Filges, Basel Sylvia Hoeller, Basel

Closing Remarks

Pre-Seminar Workshop Wednesday, June 22nd, 2016 Hirschsprung Hands-on Laboratory Workshop

(Maximum Admission 5)

Hirschsprung-Team, Basel

Elisabeth Bruder Sabine Ipsen Beatrice Maurer Thuy Nguyen Jana Schöni Myriam Vonlanthen

09.00h

Pathology Foyer

Meeting Point

09.15h – 09.45h Introduction

Pathology 3rd Floor Meeting Room

09.45h – 10.00h Coffee Break 10.00h – 11.00h Freezing of Biopsies Swiss Roll Technique

Kryo-Laboratory

11.00h – 12.00h Kryostat-Cutting

Kryo-Laboratory

12.00h – 13.00h Lunch Break 13.00h – 15.00h Enzyme Histochemical Staining Techniques and Practical Staining Exercises

Kryo-Laboratory

15.00h – 15.15h Coffee Break 15.15h – 16.30h Practical Staining Exercises

Kryo-Laboratory

16.30h – 17.30h Slide Discussion

Pathology Library

Pre-Seminar Workshop Thursday, June 23rd, 2016 Interactive Paediatric Pathology Workshop

(Maximum Admission 30)

09.00h – 09.05h Elisabeth Bruder Isabel Filges Sylvia Hoeller

Welcome & Introduction

09.05h – 09.50h Michael Ashworth, London

Heart Malformations

09.50h – 10.35h Pierre Russo, Philadelphia Liver Disease in Infancy 10.35h – 11.05h Coffee Break 11.05h – 11.50h Gordan Vujanic, Cardiff

Pitfalls and Traps in Diagnosis and Staging of Renal Tumours of Childhood

11.50h – 13.00h Gordan Vujanic, Cardiff

Selected Renal Tumours from a SIOP Reference Panel

13.00h – 14.00h Lunch Break 14.00h – 14.45h Ray Redline, Cleveland

Problems in Obstetric Pathology

14.45h – 15.30h Annette Müller, Bonn

Paediatric Lung Lesions

15.30h – 16.15h Rita Alaggio, Padova

Small Superficial Mesenchymal Lesions

16.15h – 16.45h Coffee Break 16.45h – 17.30h Anastasia Konstantinidou, Ciliopathies and Skeletal Dysplasia Athens 17.30h – 18.15h Isabel Colmenero, Madrid Skin Lesions Common to Childhood with special Emphasis on Vascular Lesions

Faculty Prof. Dr. Rita Alaggio,Istituto di anatomia patologica, Via Gabelli, 61, 35124 Padova, Italia. Tel. +39 347 800 715. Email: [email protected], [email protected] Dr. Michael T. Ashworth, Department of Histopathology, Camelia Botnar Laboratories, Great Ormond St Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK, Tel +44 207 829 8663, Email: [email protected] Prof. Dr. Isabel Colmenero, Department of Histopathology, Birmingham Children’s Hospital Steelhouse Lane, Birmingham B4 1NH, UK. Tel. +44 754 677 2909. Email: [email protected] Prof. Dr. Raoul C. Hennekam, Department of Pediatrics and Translational Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Email: [email protected] Prof. Dr. Anastasia Konstantinidou, University of Athens, 75, M. Asias Str., Goudi, Athens, 11527, Greece. Tel. +302 107 462 159. Email: [email protected] Prof. Dr. Han van Krieken, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Email: [email protected] Prof. Dr. Ronald de Krijger, Dept. of Pathology, Erasmus University Medical Center, Rotterdam, and Reinier de Graaf / Princess Maxima Hospital, Reinier De Graafweg 7, Delft / Utrecht, 2625 AD, The Netherlands. Tel. +31 481 576 49. Email: [email protected] Prof. Dr. Ivo Leuschner, Institut für Pathologie, Sektion Kinderpathologie, Universitätsklinikum Schleswig Holstein, Arnold-Heller-Str.3, Haus 14, 24105 Kiel, Germany. Tel. +49 431 597 3444. Email: [email protected] Prof. Dr. Annette Müller, Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Deutschland. Tel. +49 228 287 16487. [email protected] Prof. Dr. Luc L. Oligny, Centre Hospitalier Universitaire (CHU) Sainte-Justine (Université de Montréal), Pathology Department, 3175, Ch. De La Côte Ste-Catherine, Montréal (Quebec) H3T 1C5, Canada. Tel. +1 514 475 7811. Email: [email protected] Prof. Dr. Raymond Redline, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Tel. +1 216 844 1813. Email: [email protected] Prof. Dr. Pierre Russo, Department of Pathology, The Children’s Hospital of Philadelphia, 5207 Main Building, 321 South 34th Street, Philadelphia, PA 19104-4399, USA. Tel. +1 215 590 1733. Email: [email protected] Prof. Dr. Antonio Torrelo, Servicio de Dermatología, Hospital Infantil Universitario Niño Jesús, Avenida Menendez y Pelayo 65, 28009 Madrid, Spain. Tel. +34 915035900 ext. 291. [email protected] Prof. Dr. Gordan M. Vujanic, Department of Histopathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Tel. +44 29 2074 2706. Email: [email protected]

General Information Registration

Online registration is open at Basel Tourismus. No on site registration. Early registration is recommended.

Course Fee

The Course Fee covers expenses for facilities, breaks, faculty and administration. Registration is possible for the following Course parts: • Wednesday (CHF 100) • Thursday (CHF 100) • Friday & Saturday (CHF 200)

Venue

Pathology University Hospital Basel Schoenbeinstrasse 40 CH-4031 Basel Switzerland Tel +41 61 265 27 57 Fax +41 61 265 31 94 Email [email protected] [email protected] [email protected]

WLAN Access

Free WLAN can be accessed at all times at‚ USB_Guest_WLAN’.

CME Credits

SGPath • Friday June 24th: 7 • Saturday June 25th: 5

Workshop: • Wednesday 22nd: 6 • Thursday June 23rd: 7

EACCME credits applied.

Certificate of Attendance

Registered participants will receive a printed certificate of attendance upon arrival.

Travel Directions: Pathology at University Hospital Basel can easily be reached by public transport from Basel Airport or the Basel Swiss SBB and German Train Stations.