ARVO 2016 Annual Meeting Abstracts 313 Glaucoma Blood Flow Tuesday, May 03, 2016 8:30 AM–10:15 AM Exhibit/Poster Hall Poster Session Program #/Board # Range: 2957–3002/A0306–A0351 Organizing Section: Glaucoma Program Number: 2957 Poster Board Number: A0306 Presentation Time: 8:30 AM–10:15 AM Optic disc perfusion in eyes with primary open angle glaucoma and normal tension glaucoma using optical coherence tomography-based microangiography Karine D. Bojikian1, Chieh-Li Chen2, Joanne C. Wen1, Qinqin Zhang2, Chen Xin2, Divakar Gupta1, Raghu C. Mudumbai1, Murray A. Johnstone1, Ruikang K. Wang2, 1, Philip P. Chen1. 1 Ophthalmology, University of Washington, KIRKLAND, WA; 2 Bioengineering, University of Washington, Seattle, WA. Purpose: To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Methods: One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program (Figure 1). Results: Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p