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Alejandro Hernan Corvalan Rodriguez Portal del Investigador
1.- Personal Info First Name Middle Name Last Name Second Last Name
Alejandro Hernan Corvalan Rodriguez
Gender
Male
Degree
Professional Title
2.- Education
Professional Title Institution
Medical Doctor UNIVERSIDAD DE CHILE
Year
1985
Country
Chile
3.- Academic Experience Institution
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Faculty
Medicine
School
Medicine
Department Position Starting Year Ending Year Country City
Institution Faculty
Hematology and Oncology Associate Professor 2003 At present Chile Santiago
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Medicine
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30/01/2017 20:43 School Department Position Starting Year Ending Year Country City
Medicine Hematology and Oncology Associate Professor 2003 At present Chile Santiago
4.- Research Lines Research Lines Full-time medical researcher at Pontificia Universidad Catolica de Chile, involved in translational cancer research at basic, clinical and population levels. Research primarily focused on cancer epigenetics, systems biology and biomarker development. 5.- Current Working Status Institution Department Unit
Pontificia Universidad Catolica de Chile Hematology and Oncology Laboratorio de Oncologia
Other Position
Associate Professor
Country
Chile
Region/Province City
Region Metropolitana Santiago
6.- Professional Experience Institution/Company/Organization … Clinica Las Condes Position Starting Year
Director Molecular Biology Laboratory 1997-01-01
Ending Year
2003
Country
Chile
City
Santiago
7.- Other Relevant Info Human Capital Training
1. Ossandon F., Uso de Bioinformática como herramienta de
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30/01/2017 20:43 análisis de datos en Cáncer Gástrico, in Carrera de Bioquimica, Escuela de Ciencias Quimicas y Farmaceuticas. 2006, Universidad de Chile, Santiago. 2. Alvarez H., Estudio multietnico de la patogenesis del cancer de vesicula biliar, in Programa Doctorado en Ciencias Medicas. 2008, Pontificia Universidad Catolica de Chile, Santiago. 3. Gonzalez P., Inactivación epigenética de genes supresores de tumores como potencial marcador de riesgo de diseminación en cáncer de mama, in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica de Chile, Santiago. 4. Villarroel C., Reprimo en checkpoint g2/m y su posible rol como biomarcador en cancer gastrico., in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica.de Chile, Santiago. 5. Buchegger K., Efecto de la modulacion de la expresion de Reprimo sobre el comportamiento celular tumoral in vitro en cancer de mama, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco. 6. Droguett R., Caracterización in silico de microARNs asociados al gen RPRM mediante herramienta bioinformática, in Escuela de Ingeniería en Bioinformática, Facultad de Ingeniería. 2011, Universidad de Talca, Talca. 7. Saavedra K., Reprimo como potencial Gen Supresor de Tumores en Cáncer Gástrico, evaluación in vitro, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco. 8. Sandoval A., Rol de miR-335 y miR-597 en la pérdida de función del gen Reprimo en un modelo in vitro de cáncer gástrico, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco. 9. Garcia B., El Aumento de la expresio n endo gena de Reprimo inducido por un factor de transcripcio n artificial modifica la capacidad tumorige nica de Ca ncer Ga strico in vitro e in vivo, in Programa Doctorado en Ciencias Medicas. 2012, Pontificia Universidad Catolica de Chile, Santiago. 10. Torres V., Regulación de la expresión del gen Reprimo por metilación y su posible rol como gen supresor tumoral en cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2012, Pontificia Universidad Catolica de Valparaiso, Valparaiso. 11. Sanchez M., La inactivación del gen Reprimo por metilación de su región promotora es un evento preneoplásico y su detección cuantitativa en plasma permite la deteccion precoz de cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2013, Pontificia Universidad Catolica Valparaiso, Valparaiso. Dissemination & Transfer …
Awards and Distinctions
1. Corvalán A.H., Método de detección precoz de cáncer gástrico que comprende detectar la presencia de marcadores específicos de cáncer gástrico en muestras de plasma. INAPI, Chile. WO 2011/035453 A2, PCT/CL2010/000041 AVONNI en Salud (FORO INNOVACION, Chile, 2011). 2001 award for the discovery of a potential biomarker for early detection of gastric cancer in plasma.. www.avonni.cl
Productividad
Journal Article
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients User Generated Tang H., et al.,
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30/01/2017 20:43 2013 Producción pendiente de validación por CONICYT Journal Article
Síndrome de Lynch: selección de pacientes para el estudio genético mediante análisis de inestabilidad microsatelital e inmunohistoquímica SCIELO Wielandt A.M.; Zárate A.J.; Hurtado C.; Orellana, P; Alvarez K.; Pinto E.; Contreras L.; Corvalan A.; Kronberg U.; Lopez-Kostner, F 2012 Journal Article
Functional Interaction between Human Papillomavirus Type 16 E6 and E7 Oncoproteins and Cigarette Smoke Components in Lung Epithelial Cells ISI Munoz J.P.; González C; Parra B.; Corvalán A.H.; Tornesello M.L.; Eizuru, Y; Aguayo F. 2012 Journal Article
Merkel cell polyomavirus in non-small cell lung carcinomas from Chile ISI Gheit T.; Munoz J.P.; Levican, J; González C; Ampuero, S; Parra B.; Gaggero, A; Corvalán A.H.; Meneses, M; Tommasino M.; Aguayo F. 2012 Review
Teneurin protein family: An emerging role in human tumorigenesis and drug resistance ISI 2012 Editorial Material
Early Diagnosis of Hepatocellular Carcinoma by MicroRNAs: Shining a Light from the Genome's "Dark Matter" ISI 2012 Generic
SCREENING AND TRIAGE TEST FOR EARLY DETECTION OF GASTRIC CANCER (STEAD-GC) ISI Corvalan A.; Calvo A.; Ferreccio C.; Maturana M.; Cook P.; Sánchez, M; Aravena, E; Barrientos C.; Estela R. 2012 Producción pendiente de validación por CONICYT
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30/01/2017 20:43 Journal Article
Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis ISI Camargo, MC; Murphy G.; Koriyama, C; Pfeiffer, RM; Kim, WH; Herrera-Goepfert, R; Corvalan, AH; Carrascal, E; Abdirad A.; Anwar M.; Hao Z.; Kattoor J.; Yoshiwara-Wakabayashi E.; Eizuru, Y; Rabkin, CS; Akiba, S 2011 Journal Article
High-risk HPV infection after five years in a population-based cohort of Chilean women ISI Ferreccio C.; Van De Wyngard V.; Dominguez M.A.; Puschel, K; Corvalán A.H.; Olcay, F; Franceschi S.; Snijders P.J.F. 2011 Journal Article
Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile ISI Aguayo F.; González C; Ampuero, S; Khan N.; Koriyama, C; Akiba, S; Padilla O.; Solís L.; Eizuru, Y; Corvalan A. 2011 Journal Article
Identification of the distinctive type i/XhoI+ strain of epstein-barr virus in gastric carcinoma in Peru SCOPUS Ordonez P.; Koriyama, C; Ding, S; Akiba, S; Yoshiwara E.; Takano J.; Watanabe, J; Miyagui J.; Corvalán A.H.; Chirinos J.L.; Hidalgo, H; Chacon, P; Linares V.; Eizuru, Y 2011 Producción pendiente de validación por CONICYT Journal Article
Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres chilenas: Un estudio de casos y controles SCIELO SOLIS, MARÍA TERESA; Aguayo Francisco; Vargas, Macarena; Olcay, Fabiola; Puschel, Klaus; Corvalán, Alejandro; Ferreccio, Catterina 2010 Journal Article
Helicobacter pylori-Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells ISI Valenzuela M.; Perez-Perez, G; Corvalan, AH; Carrasco G.; Urra H.; Bravo D.; Toledo H.; Quest, AFG 2010 Journal Article
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30/01/2017 20:43 Overexpression of p73 as a Tissue Marker for High-Risk Gastritis ISI Carrasco G.; Díaz J.; Valbuena, JR; Ibáñez P.; Rodríguez, P.; Araya, G; Rodriguez, C.; Torres, J.; Duarte I; Aravena, E; Mena, F; Barrientos C.; Corvalan, AH 2010 Journal Article
Human papillomavirus (HPV) genotypes in cervix uterine cancer patients in a public hospital and private clinic from Santiago, Chile ISI Valdivia, IM; Aguayo F.; Pruyas, M; Snijders, PJF; Corvalan A.; Ferreccio C. 2010 Journal Article
Recent patents of DNA methylation biomarkers in gastrointestinal oncology SCOPUS Corvalán A.H.; Maturana M.J. 2010 Producción pendiente de validación por CONICYT Journal Article
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study ISI Solis, MT; Aguaya, F; Vargas M.; Olcay, F; Puschel, K; Corvalan A.; Ferreccio C. 2010 Journal Article
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres Chilenas: Un estudio de casos y controles SCOPUS Solis M.T.; Ferreccio C.; Aguayo F.; Vargas M.; Corvalan A.; Olcay, F; Puschel, K 2010 Producción pendiente de validación por CONICYT Generic
A Multiple Testing Approach for Histological and Molecular Markers for Early Gastric Cancer ISI Carrasco G.; Ibáñez P.; Valbuena, JR; Mena, F; Aguayo FR; Ferreccio C.; Corvalan A. 2009 Producción pendiente de validación por CONICYT Journal Article
Baseline assessment of prevalence and geographical distribution of HPV types in Chile using selfcollected vaginal samples
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30/01/2017 20:43 ISI - SCOPUS Ferreccio C.; Corvalan A.; Margozzini P.; Viviani, P; González C; Aguilera, X; Gravitt, PE 2008 Journal Article
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis SCIELO - SCOPUS Bernal, Carolina; Vargas, Macarena; Ossandon, Francisco; Santibañez, Eudocia; Urrutia, Julio; Luengo, Victor; ZAVALA, LUIS F; Backhouse, Claudia; Palma, Mariana; Argandona, Jorge; Aguayo Francisco; Corvalán, Alejandro 2008 Journal Article
In Silico analysis of Gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity ISI - SCOPUS Ossandon FJ; Villarroel C; Aguayo F.; Santibanez, E; Oue, N; Yasui, W; Corvalan, AH 2008 Journal Article
Mismatch repair expression in testicular cancer predicts recurrence and survival ISI - SCOPUS Velasco A.; Corvalan A.; Wistuba, II; Riquelme E.; Chuaqui, R; Majerson, A; Leach, FS 2008 Journal Article
Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer ISI - SCOPUS Bernal, C.; Aguayo F.; Villarroel C; Vargas M.; Díaz I.; Ossandon FJ; Santibanez, E; Palma M.; Aravena, E; Barrientos C.; Corvalan, AH 2008 Journal Article
Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer ISI - SCOPUS Álvarez H; Corvalan A.; Roa JC; Argani, P; Murillo, F; Edwards, J; Beaty, R; Feldmann, G; Hong, SM; Mullendore, M; Roa I.; Ibanez, L; Pimente, F; Diaz, A.; Riggins, GJ; Maitra, A 2008 Journal Article
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis ISI
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30/01/2017 20:43 Bernal, C.; Vargas M.; Ossandon, F; Santibanez, E; Urrutia J.; Luengo, V; Zavala, LF; Backhouse, C; Palma M.; Argandoña J.; Aguayo F.; Corvalan A. 2008 Generic
Inactivation of cell cycle regulatory genes in ovarian cancers ISI Corvalan A.; Rahama, J; Riquelme E.; Wu H.; Dottino, PR; Kalir, T 2008 Producción pendiente de validación por CONICYT Journal Article
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors ISI - SCOPUS Tapia T.; Smalley, SV; Kohen, P; MuÑoz A.; Solis, LM; Corvalan A.; Faundez, P; Devoto L.; Camus M.; Álvarez, M.; Carvallo P. 2008 Punto De Vista
Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama SCIELO 2007 Journal Article
Analytical detection of immunoglobulin heavy chain gene rearrangements in gastric lymphoid infiltrates by peak area analysis of the melting curve in the LightCycler System ISI - SCOPUS Retamales E.; Rodríguez L.; Guzmán L.; Aguayo F.; Palma M.; Backhouse, C; Argandoña J.; Riquelme E.; Corvalan A. 2007 Journal Article
Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus ISI - SCOPUS Valbuena, JR; Retamal, Y; Bernal, C.; Eizuru, Y; Corvalan A. 2007 Journal Article
Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma ISI - SCOPUS Riquelme E.; Tang M; Baez S.; Diaz, A.; Pruyas, M; Wistuba, II; Corvalan A. 2007
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30/01/2017 20:43 Journal Article
High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile SCIELO GUZMAN, LEDA M; Koriyama, Chihaya; Akiba, Suminori; Eizuru, Yoshito; Castillo, Darwins; Corvalán, Alejandro; AGUAYO, FRANCISCO R 2007 Journal Article
Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile ISI - SCOPUS Aguayo F.; Castillo A; Koriyama, C; Higashi, M; Itoh, T; Capetillo, M; Shuyama, K; Corvalan A.; Eizuru, Y; Akiba, S 2007 Journal Article
Nasal natural killer/T-cell lymphoma and its association with type i"/Xhol loss strain Epstein-Barr virus in Chile" ISI - SCOPUS Cabrera, ME; Eizuru, Y; Itoh, T; Koriyama, C; Tashiro, Y; Ding, S; Rey, S.; Akiba, S; Corvalan A. 2007 Generic
A new epithelial mapping system use cytology prep to detect gallbladder adenocarcinoma on the operative room ISI Alvarez, HA; Zarate, A; Castiblanco, A; Madrid P.; Aguayo G.; Giannini, MJ; Alvarez, MDLA; Duarte I; Pimentel F.; Ibanez, L; Diaz, A.; Corvalan A. 2007 Producción pendiente de validación por CONICYT Journal Article
E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance ISI - SCOPUS Koriyama, C; Akiba, S; Itoh, T; Sueyoshi, K; Minakami, Y; Corvalan A.; Yonezawa, S; Eizuru, Y 2007 Journal Article
Gene expression profiles for therapeutic decisions in breast cancer ISI Corvalan A. 2007 Generic
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30/01/2017 20:43 Gene expression profiles for therapeutic decisions in breast cancer Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama SCOPUS Corvalan A. 2007 Producción pendiente de validación por CONICYT Journal Article
Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes ISI Zavala, L; Luengo, V; Ossandon, F; Riquelme E.; Backhouse, C; Palma M.; Argandoña J.; Cumsille, MA; Corvalan A. 2007 Journal Article
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile ISI - SCOPUS Guzman, LM; Koriyama, C; Akiba, S; Eizuru, Y; Castillo D.; Corvalan A.; Aguayo FR 2007 Journal Article
Association of a distinctive strain of Epstein-Barr virus with gastric cancer ISI - SCOPUS Corvalan A.; Ding, S; Koriyama, C; Carrascal, E; Carrasquilla, G; Backhouse, C; Urzua, L; Argandoña J.; Palma M.; Eizuru, Y; Akiba, S 2006 Journal Article
Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile ISI - SCOPUS Castillo A; Aguayo F.; Koriyama, C; Torres M.; Carrascal, E; Corvalan A.; Roblero, JP; Naquira, C; Palma M.; Backhouse, C; Argandoña J.; Itoh, T; Shuyama, K; Eizuru, Y; Akiba, S 2006 Journal Article
Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis ISI Castiblanco, A; Pires, N; Wistuba, I; Riquelme E.; Andrade, L; Corvalan A. 2006 Journal Article
Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus ISI
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30/01/2017 20:43 Corvalan A.; Akiba, S; Valenzuela, MT; Cumsille, MA; Koriyama, C; Argandoña J.; Backhouse, C; Bal, M; Mena, F; Palma M.; Eizuru, Y 2005 Generic
CpG island methylation profile in gastric carcinoma ISI Corvalan A.; Backhouse, C; Wistuba, I; Aguayo F.; Cumsille, MA; Palma M.; Riquelme E.; Argandoña J.; Luengo, V; Akiba, S; Koriyama, C; Eizuru, Y 2004 Producción pendiente de validación por CONICYT Generic
Detection of oligoclonal immunoglobulins heavy chain gene rearrangement (IgH) by melting curve analysis in gastric lymphoid infiltrates. ISI Corvalan A.; Retamales E.; Guzmán L.; Torres, J.; Riquelme E.; Palma M.; Backhouse, C 2004 Producción pendiente de validación por CONICYT Journal Article
Prognostic significance of Epstein-Barr virus involvement in gastric carcinoma in Japan ISI Koriyama, C; Akiba, S; Itoh, T; Kijima, Y; Sueyoshi, K; Corvalan A.; Herrera-Goepfert, R; Eizuru, Y 2002 Journal Article
Epstein-Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile ISI - SCOPUS Corvalan A.; Koriyama, C; Akiba, S; Eizuru, Y; Backhouse, C; Palma M.; Argandoña J.; Tokunaga, M 2001 Journal Article
Gastric permeability is not increased in children colonized by CagA-positive strains of Helicobacter pylori ISI - SCOPUS Gotteland M.; Corvalan A.; Sarmiento, F; Chávez E.; Backouse, C; Palma M.; Kakarieka, E; Vial, MT; Figueroa G. 2001 Generic
Helicobacter pylori: cagA status and vacA genotyping in Chile. Detection of a s2/m1 strain ISI Martinez, TA; Gonzalez, CC; Kawaguchi, PF; Montoya R; Corvalan A.; Madariaga, J; Roa J; Garcia, CA; Salgado F.; Solar H.; Palma M.
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30/01/2017 20:43 2001 Producción pendiente de validación por CONICYT Journal Article
Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer User Generated Carrasco G.; Corvalan A. Producción pendiente de validación por CONICYT Journal Article
Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis. User Generated Camargo et al. Producción pendiente de validación por CONICYT
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