William Darko, B.Pharm., Pharm.D. Curriculum Vitae HOME ADDRESS 5426 Quamby Road Clay, New York 13041 [email protected] BUSINESS ADDRESS State University of New York (SUNY) Upstate Medical University Hospital Department of Pharmaceutical Care Services 750 East Adams Street Syracuse, New York 13210 E – Mail: [email protected] EDUCATION AND POSTGRADUATE TRAINING August 2001 – July 2002

Critical Care Specialty Residency (PGY – 2 ) ASHP Accredited Kingsbrook Jewish Medical Center and Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Brooklyn, New York

July 2000 – June 2001

Pharmacy Practice Residency (PGY – 1) ASHP Accredited SUNY Upstate medical University Syracuse, New York

August 1998 - June 2000

Doctor of Pharmacy Program (Pharm.D.) Albany College of Pharmacy Albany, New York

August 1989 – June 1993

Bachelor of Pharmacy [B.Pharm. (Hon’s)] University of Science and Technology Kumasi, Ghana West Africa

ACADEMIC APPOINTMENTS September 2002 – Present

Assistant Professor of Medicine Department of Medicine, Section of Clinical Pharmacology SUNY Upstate Medical University Syracuse, New York

September 2003 – Present

Associate Professor of Pharmacy Practice (Adjunct Faculty) Wilkes University, Nesbitt College of Pharmacy and Nursing Wilkes, PA

August 2001 – July 2002

Clinical Assistant Professor of Pharmacy Practice Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Brooklyn, New York

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-2-

EMPLOYMENT HISTORY February 2006 – Present

Director of Pharmacy Practice Residency Program (PGY – 1) SUNY Upstate Medical University Hospital Syracuse, New York

August 2002 – Present

Clinical Pharmacist, Cardiovascular & Critical Care Services SUNY Upstate Medical University Hospital Department of Pharmaceutical Care Services Syracuse, New York Supervisor: Joseph J. Medicis, Pharm.D. BCPS – 2002 – 2005 Supervisor: John Noviasky, Pharm.D - 2007 - Present

December 1997 – June 1998

Volunteer (Pharmacy Technician) Beth Abraham Health Services Pharmacy Department Bronx, New York Supervisor: William Marsden, B.S. R.Ph. (Director of Pharmacy)

January 1996 – March 1997

Medical Sales Representative KinaPharma Company Limited Accra, Ghana West Africa Supervisor: Kofi Nsiah – Poku, B.Pharm, MPSG (Managing Director)

October 1994 – December 1995

Community Pharmacy Practice KinaPharma Company Limited Accra, Ghana West Africa Supervisor: Kofi Nsiah – Poku, B.Pharm, MPSG (Managing Director)

August 1993 – December 1995

Hospital Pharmacy Practice 37 Military Hospital Accra, Ghana West Africa Supervisor: Nancy Owusu, B.Pharm, MPSG (Chief Pharmacist)

LICENSURE 2002 – Present

New York State (United States of America)

1994 – Present

Ghana, West Africa.

PROFESSIONAL SOCIETIES/MEMBERSHIP 2001 – 2007

Society of Critical Care Medicine

2000 – 2006

New York State Chapter of Health –System Pharmacists

1999 – 2005

New York State Infectious Diseases Pharmacotherapy Society

1999 – Present

American Society of Health-System Pharmacists

1999 – 2005

New York State Chapter of American College of Clinical Pharmacists

1994 – Present

Pharmaceutical Society of Ghana, West Africa

Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae RESEARCH AND PUBLICATIONS Peer Review Journals

-3-

1.

William Darko, David Lehmann, Clarifying the Relationship between the Pharmacodynamics of Thiazolidinediones and Adverse cardiovascular effects (in press)

2.

Brianne Hefty, William Darko, John Noviasky et al. A Case of cross reactivity to alteplase in a patient with a history of angioedema (in press)

3.

William Darko, Gregory Cwikla, David lefever, et al Falsely Low Serum Vancomycin Concentrationswith QMS® Vancomycin Assay (in press)

4.

David K Burchette, William Darko,James Zhara, John Noviasky, Luke Probst and Adrienne Smith .Mixing and compatibility guide for commonly used aerosolized medications (Accepted for publication AJHP)

5.

Luke Probst, William Darko, Adrienne Smith, Gregory Cwikla. Pitfalls of the Application of Modification of Diet in Renal Disease (MDRD) Equation to drug Dosing: A Tertiary Care Teaching Hospital Experience. Hospital Pharmacy 2008;43:564 – 570

6.

R. Guharoy, J. Bradshaw, C. Han, C. Churmusi, S. Baxter, A. Smith, W. Darko, L. Probst Incidence of ADEs in Patients Readmitted within 30 days of Discharge in a Tertiary care Teaching Hospital. Formulary 2007;42:691 – 694

7.

Darko W., Medicis J., Guharoy R., Smith A. Mississippi Mud no More: Cost – Effectiveness of Pharmacokinetic Dosage Adjustment of Vancomycin to Prevent Nephrotoxicity Pharmacotherapy 2003;23(5):643 – 650

8.

John A. Noviasky, Michael Kelberman, Karen M. Whalen, Roy Guharoy and William Darko. Science or Fiction: Use of Nesiritide as a First – Line Agent?. Pharmacotherapy 2003;23(5):643 - 650

9.

Darko W., Smith LA., King LE., Grethlein JS., Lehman D. Mitoxantrone –Induced Cardiotoxicity Journal of Oncology and Pharmacy Practice 2002;7(1)

10. Darko W., Guharoy R., Lehmann D., Rose F., Pappas VK. Myoclonus Secondary to the Concurrent use of Trazodone and Fluoxetine Veterinary and Human Toxicology 2000;43 (4):214 – 215 Abstracts 1.

Darko W., Guharoy R., Blair D., Sam K., Schachtner J. Evaluation of Clostridium Difficile Associated Diarrhea in a Tertiary Care Teaching Hospital. American College of Clinical Pharmacy, 2001 Spring Practice and Research Forum, Salt Lake City, Utah Pharmacotherapy 2001;21(3):386

2.

Guharoy R., Darko W. Ramirez L., Turchik J., Khan M., Blair M., Anuria and Acute Renal Failure after Two Prophylactic Doses of Indinavir Clinical Pharmacology and Therapeutics 2000;67(2):131

Pending Research Projects 1. 2. 3.

Evaluating the risk of discharge home on antipsychotic medications after treatment of ICU delirium Appropriate Use of Vitamin K in a Tertiary Care Teaching Hospital Determining the optimal dose of warfarin in patients with thyroid disorders

Revised: January, 2008

4. 5.

William Darko, B.Pharm., Pharm.D. Curriculum Vitae -4Evaluating the correlation of MDRD and Cockcroft – Gault equations in estimating renal function using gentamicin clearance Estimating the correlation between MDRD and Cockcroft – Gault equations and gentamicin clearance in the older population for the purpose of drug dosing

PRESENTATIONS Continue Professional Education Lectures and Medical Ground Rounds 1.

Acid base Disorders: The Basics for Pharmacists Pharmacy Grand Rounds SUNY Upstate Medical University Hospital March 18the 2009

2.

Falsely Low Vancomycin Serum Concentrations with QMS Vancomycin Assay Presented to Physicians at Infectious Diseases Grand Rounds SUNY Upstate Medical University Hospital December 2008

3.

MDRD vs. Cockroft – Gault Equations for Medication Dosing Presented at Medical Ground Rounds to Medical Residence and fellows SUNY Upstate Medical University Hospital August 2007

4.

Management of In – patient Hypertension Presented at Medical Ground Rounds to Medical Residents SUNY Upstate Medical University Hospital, Syracuse, New York April, 2006

5.

Dofetilide Administration and Monitoring in patients with Atria Fibrillation In-service Lecture to Pharmacist and Nurses at SUNY Upstate University Hospital March 2006

6.

The Clinical Pharmacology of Beta-Lactam Antimicrobial Agents. Presented to pharmacist at: Holiday Inn, JFK Airport, Jamaica, New York, May 19, 2002 Presented to pharmacist at: Horton Hospital, Middletown, New York, June 23, 2002

Poster Presentations 1.

Abby LaHart, William Darko, Rendell Ashton. A case of corticosteroid desensitization in a patient with steroid allergy and Acute Asthma Exacerbation. Presented at the 42nd Annual ASHP Midyear Clinical Meeting, Las Vegas, Nevada December, 2007

2.

Christine Han, William Darko, Luna Bhatta, Ashish Maskeyk, Kathleen Carroll. Rapid Aspirin Desensitization: A case of a patient Requiring Dual Antiplatelet therapy after Percutaneous Coronary intervention. Presented at the 42nd Annual ASHP Midyear Clinical Meeting, Las Vegas, Nevada December, 2007

3.

Kristyn Churmusi, Lisa Phillips, William Darko. Evaluation of Serum Digoxin Concentration in an Internal Medicine Ambulatory Care Chronic Heart failure Population Presented at the 41st Midyear Clinical Meeting, Anaheim CA December 2006

Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-5-

Poster Presentations cont 4.

W Darko, R.Guharoy and B.Stalder. Evaluating the Appropriate use of Pantoprazole in an Internal Medicine Service of a Tertiary care Teaching Hospital; Presented at the 41st Midyear Clinical Meeting, Anaheim CA December 2006

5.

Bruce Stalder, Roy Guharoy, Luke Probst, Adrienne Smith, William Darko, Travis Boevin Optimization of clinical Services via effective use of wireless Technology. Presented at the 41st Annual ASHP Midyear Clinical Meeting. Anaheim, CA December 2006

6.

Roy Guharoy, Jonathan Bradshaw, Adrienne Smith, Luke Probst and William Darko. Incidence of Adverse drug Reactions on Hospital Readmission within 30 days of hospital Discharge in a tertiary Care Teaching Hospital, Presented at the 41st Annual ASHP Midyear Clinical Meeting. Anaheim, CA December 2006

7.

William Darko, Joseph Medicis, Roy Guharoy and, Adrienne Smith. The incidence of Acute Renal Failure associated with the Use of Nesiritide in a Tertiary care Teaching Hospital Presented at the 39th Annual ASHP Midyear Clinical Meeting at Las Vegas, Nevada December, 2005

8.

Jeanna Marraffa, William Darko, Christine Stork, Daniel Villarreal. Methadone – Induced QT Prolongation Presented at the Annual Toxicology Conference, October 2005

9.

Sarah Barth, William Darko, Roy Guharoy. The Use of Drotregogen alpha in a Tertiary Care Teaching Hospital Presented at the 38th Annual ASHP Midyear Clinical Meeting, Orlando Florida December 2004

10. William Darko, James Zahra, Joseph Medicis. The Impact of Guidelines on the Pharmacy Operation in a Tertiary Care Teaching Hospital Presented at the 38th Annual ASHP Midyear Clinical Meeting, Orlando Florida December 2004. 11. Roy Guharoy, John Noviasky, William Darko. National Survey on Nesiritide Utilization in U.S Hospitals and Potential for Rational Utilization. Presented at the 38th Annual ASHP Midyear Clinical Meeting, New Orleans, Louisiana. December 2003 12. Roy Guharoy, Donald Blair, Frederick Rose, William Darko, and Bishoy Luka. Impact of MultiDisciplinary Infectious Disease Management Team on Reduction of Resistance & Broad Spectrum Antimicrobial Use in a Tertiary Care Teaching Hospital. Presented at the 38th Annual ASHP Midyear Clinical Meeting, New Orleans, Louisiana. December 2003 13. A Smith, J Medicis, W. Darko. Homeless Clinic: A Home Away from Home for a Pharmacy practice Resident Primary Care Experience. Presented at the 38th Annual ASHP Midyear Clinical Meeting, New Orleans, Louisiana. December 2003 14. Darko W, and Cohen H. Enalapril-Induced Life-Threatening Interdialytic Hyperkalemia. Presented at the 37th Annual ASHP Midyear Clinical Meeting, Atlanta, Georgia Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-6-

December 2002. Poster Presentations cont 15. Darko W., Guharoy R., Medicis J., Smith A., Pappas VK. Evaluation of Clostridium difficile associated diarrhea in a Tertiary Care Teaching Hospital Presented at 35th Midyear Clinical Meeting, Las Vegas, Nevada December 2000. 16. Awodero S., Guharoy R., Darko W. Use of Ceftriaxone in a Tertiary Care Teaching Hospital Presented at the 35th Midyear Clinical meeting, Las Vegas, Nevada December 2000. 17. Darko W., Guharoy R., Ramirez L., Turchik J., Khan M., Blair D., Viola S. Anuria and Acute Renal Failure after Two Prophylactic Doses of Indinavir Presented at the 34th Annual ASHP Midyear Clinical Meeting Orlando, Florida December 1999. 18. Darko W. and Lomaestro B. Prescription Pattern in UTI, Bronchitis, and Pneumonia Presented at Albany Medical Center, Albany, New York October 1999. Lectures 1.

Managing the Heart Failure Patient. Cardiovascular Case – Based Lecture for Forth Year Medical Students at SUNY Upstate Medical University, Syracuse New York 2008

2.

Cardiovascular Pharmacology: (Hypertension, Heart failure and Hyperlipidemia): Course Lecture for nurse practitioners at SUNY Upstate Medical University, Syracuse New York, 2008

3.

Management of Asthma and COPD: Course lecture for nurse practitioners at SUNY Upstate Medical University, Syracuse New York April 2005 to 2007

4.

Therapeutics of Heart Failure: Lecture for 4th year medical students in Clinical Pharmacology and Therapeutics selective course at SUNY Upstate Medical University March 2006/2007

5.

Management of In – Patient Hypertension Presented to Medical Residents (noon conference) at SUNY Upstate Medical University Hospital October, 2005

6.

Management of Patients with Atria Fibrillation; The Role of Dofetilide Presented to the Nursing and Pharmacy staff at SUNY Upstate, Medical University Hospital April, 2005

7.

Clinical Pharmacology of Heart Failure Medications (a case based lecture). Lecture for 2nd year medical students in Clinical Pharmacology Elective at SUNY Upstate Medical University. February 2004

8.

Alternatives to Vancomycin for the Treatment of Methicillin Resistance Staphylaccocus Aureus, Presented to pharmacists and surgical residents at Kingsbrook Jewish Medical Center, Brooklyn, New York June 2002

9.

Natriuretic Peptides in the Management of Acute Exacerbation of Congestive Heart Failure: A review of the Literature. Presented to Pharmacist at Maimonides Medical Center Brooklyn, New York

Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-7-

April 2002 Lectures cont. 10. Heparin-Induced Thrombocytopenia. Presented to Pharmacist at Maimonides Medical Center, Brooklyn New York April 2002. 11. Establishing a Pharmacy-Based Asthma Service. Presented to Pharmacist and Pharmacy Students at Maimonides Medical Center, Brooklyn, New York. April 2002 12. Gatifloxacin-Induced Acute Hepatotoxicity. Presented to Pharmacy Practice Residents, Pharmacy Students and Pharmacist at Kings Brook Jewish Medical Center Brooklyn, New York March 2002 13. Glycoprotein IIb/IIIa Inhibitors in Unstable Angina & Non ST-Segment Elevation Myocardial Infarction: A Review of The PRISM-PLUS and PURSUIT Trials Presented to medical residents at Kingsbrook Jewish Medical Center, Brooklyn New York February 2002 14. Noninvasive Treatment of Acute Nonvariceal Upper Gastrointestinal Hemorrhage Presented to pharmacy practice residents, pharmacists and Doctor of Pharmacy students at Kingsbrook Jewish Medical Center, Brooklyn, New York January 2002 15. Clinical Pharmacology of Heparin, LMWH and Fondaparinux Presented to medical residents at Kingsbrook Jewish Medical Center, Brooklyn, New York January 2002 16. Treatment of Hypertensive Crisis Presented to medical residents at New York University Medical Center New York, New York November 2001 17. Stress Ulcer Prophylaxis in the ICU: The role of H2-antagonist, Sucralfate and Proton-pump Inhibitors Presented to pharmacists at Kingsbrook Jewish Medical Center, Brooklyn New York October 2001 18. Mechanism of Resistance in Gram-Negative Bacteria Presented to pharmacy practice residents and infectious diseases consult team at Veteran Affairs Hospital, Bronx, New York September 2001. 19. Candidemia Presented to pharmacy practice residents and Infectious Diseases Consult team at Veteran Affairs Hospital, Bronx, New York September 2001. 20. Pathophysiology and Therapeutics of Nausea and Vomiting, Diabetic Gastroparesis and Constipation Presented to nurses at College of Nursing, Upstate Medical University, Syracuse, New York February 2001. 21. Clinical Pharmacokinetics and Dosing of Aminoglycosides and Vancomycin Presented to all Doctor of Pharmacy students on clinical clerkship rotations at University Hospital, Upstate Medical University, Syracuse, New York October 2000 – April 2001. Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-8-

Lectures cont. 22. Pathophysiology and Therapeutics of Pneumonia, Meningitis and CSF Shunt Infections Presented to all Doctor of Pharmacy students on infectious disease clinical rotation at University Hospital Upstate Medical University, Syracuse, New York October 2000 – April 2001. 23. Literature Review of Argatroban for Heparin – Induced Thrombocytopenia Presented to the Pharmacy and Therapeutic committee at University Hospital, Upstate Medical University, Syracuse, New York June 2001. 24. Mississippi Mud no More: Cost – Effectiveness of Pharmacokinetic Dosage Adjustment of Vancomycin to Prevent Nephrotoxicity Platform presentation at the Twentieth Annual Eastern States Conference for Pharmacy Practice Residents and Preceptors April 2001. 25. Pathophysiology and Therapeutics of Nausea and Vomiting, Diabetic Gastroparesis and Constipation . Presented to nurse practitioners at College of Nursing, Upstate Medical University, Syracuse, New York February 2001. 26. Treatment of Idiopathic Thrombocytopenic Purpura (ITP) Presented to the Oncology Team, Upstate Medical University Hospital, Syracuse, New York January 2001. 27. The role of Amiodarone in Ventricular Tachycardia and Ventricular Fibrillation Presented to the pharmacists and surgical residents at University Hospital, Upstate Medical University, Syracuse, New York February 2000. 28. The Future of Glycoprotein IIb/IIIa Inhibitors in Acute Coronary Syndromes. Presented to the pharmacists at University Hospital, Upstate Medical University, Syracuse, New York March 2000. 29. Hypertension in End Stage Renal Disease Presented to nurses at Albany Dialysis Center, Albany, New York April 2000. 30. Vitamin D Analogues in Renal Oesteodystrophy Presented to nurses at Albany Dialysis Center and nurses and pharmacist at Albany Visiting Nurses Association, Albany, New York April 2000. 31. The Thienopyridines in Thrombotic Thrombocytopenic Purpura Presented to the medicine team at St Peters Hospital, Albany, New York May 2000. 32. Pharmacoeconomic Methods Presented to the pharmacists at St Peters Hospital, Albany, New York May 2000. 33. Central Anticholinergic Syndrome Presented to the emergency department residents at SUNY, Upstate University Hospital, Syracuse, New York Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae

-9-

July 2000.

Lectures cont. 34. Mechanisms of Antimicrobial Resistance Presented to the pharmacists at SUNY, Upstate University Hospital, Syracuse, New York August 2000. 35. Tolcapone: A Novel Agent for Parkinson’s disease Presented to the nursing staff at Albany Visiting Nurses Association, Albany, New York November 1999. 36. Fluoroquinolone Interaction at Gastrointestinal Absorption Site Presented to the nursing staff at Albany Visiting Nurses Association, Albany, New York November 1999. 37. Gatifloxacin, an Emerging Fluoroquinolone Presented to pharmacists at Albany Medical Center. Albany, New York October 1999. 38. Prescribing Pattern in UTI, Bronchitis, and Pneumonia Presented to the Antimicrobial Committee, Albany Medical Center, Albany, New York October 1999. 39. Anuria and Acute Renal Failure after Two Prophylactic Doses of Indinavir Presented at the Twelfth Annual New York State Infectious Disease Pharmacotherapy Meeting at Syracuse, New York. September 1999. 40. Review of Zanamivir and Rimantadine in Influenza Viral Infection Presented to pharmacists at Glens Falls Hospital. Glens Falls, New York September 1999. CIRTIFICATION: 2001 – Present: Advance Cardiac Life Support (ACLS) COMMITTEES August

2002 – Present

Pharmacy and Therapeutic Committee:

November 2003 – Present

Acute Coronary Syndrome Critical Pathway Development

September 2003 – Present

Medicine Quality Improvement

September 2003 – Present

Cardiovascular Quality Improvement

September 2002 – Present

Clinical Pharmacology Education and Training for Medical Students

September 2002 – Present

Pharmacy Education/Training Committee

September 2002 – Present

Clinical Committee – Department of Pharmacy

ADMINISTRATIVE RESPONSIBILITIES April 2007 to Present Revised: January, 2008

Coordinator of 4th year Medical Students Clinical Pharmacology Selective

February 2006 to Present

William Darko, B.Pharm., Pharm.D. Curriculum Vitae Director, Pharmacy Practice Residency Program (PGY – 1)

May 2005 –Present

Coordinator of Cardiovascular/Critical Care Policy Enforcement

July 2004 – Present

Coordinator of Pharmacy Practice Residency Recruitment

September 2002 – Present

Coordinator, Doctor of Pharmacy Students Clerkships, SUNY Upstate Medical University Hospital

January 2003 – Present

Coordinator of Hope Clinic Pharmacy Activities, Syracuse New York

- 10 -

COMPLETED P&T PROJECTS Formulary Monographs Formulary Monographs cont 1. Bivalirudin: for the use in patients with history of heparin – induced thrombocytopenia requiring cardiac surgery 2. Bivalirudin: For use in patients undergoing percutaneous coronary intervention 3. Paliperidone for the treatment of patients with schizophrenia 4. Ranolazine for the management of patients with chronic stable angina Medical Service Protocols 1. Nesiritide administration policy/protocol 2. Pulmonary hypertension management protocol 3. Dofetilide administration protocol 4. Ranolazine administration protocol 5. White paper and policy on the use of Modification of Diet in Renal Disease (MDRD) equation in drug dosing 6. Assessment and Treatment of Delirium in the Intensive Care Unit 7. Compatibility Chart for Aerosolized Medications 8. Rapid Aspirin desensitization protocol 9. Management of Hypertensive emergency HONORS/AWARDS 1999/2000

Dean’s List, Albany College of Pharmacy

COMMUNITY SERVICE January 2009 to present

Involved in collecting used clothing/Shoes for donation to Orphans is Ghana, West Africa (about $9,000.00 of items shipped so far)

May 2008

Medication Education for Cardiac Device Patients

June 2007 to Present

Monthly Medication Education for Cardiac Rehabilitation Patients

August 2002 to present:

Hope Clinic Services

July 2002

Management of Hypertension Church of Pentecost, Bronx, New York

June 2002

“Brown Bag” Program: Counseling Patients at Health fair, Brooklyn, New York

November 2001

Counseling New York State Postal Workers on Antibiotic Prophylaxis Against Anthrax Infection. Morgan Post Office, New York, New York

Revised: January, 2008

William Darko, B.Pharm., Pharm.D. Curriculum Vitae REFERENCES: Available upon request

Revised: January, 2008

- 11 -