What is ARDS? Acute Respiratory Distress Syndrome (ARDS): How do we Improve Oxygenation?
ARDS Clinical Syndrome of acute respiratory failure due to acute lung inflammation and noncardiogenic pulmonary edema that often leads to multiorgan system failure and death
Chad Cannon, PharmD., BCPS
Bernard,GR et al. Am J Resp Crit Care Med. 1994;149: 818-824.
Disclosure I do not have a vested interest or affiliation with any corporate organization offering financial support or grant monies for this continuing education activity, or any affiliation with an organization whose philosophy could potentially bias my presentation.
ARDS Criteria Timeline
1967 Case Series published on ARDS
1980 ARDS defined
1988 Murray Lung Injury Score
1994 American‐ European Consensus
2005 Delphi Definition
2011 Berlin Definition of ARDS
Thompson BT et al. Semin Respir Crit Care Med.2013;34:441-447.
Objectives Define ARDS and associated risk factors Outline pathophysiology of ARDS Evaluate current literature on optimal therapies for ARDS Consider future therapies for ARDS
ARDS Berlin Definition Timing Within 1 week of a known clinical insult or new worsening respiratory symptoms
Chest imaging Bilateral opacities Not fully explained by effusions, lobar/lung collapse, or nodules
Rubenfeld GD et al. JAMA. 2012;307(23):2526-2533.
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ARDS Berlin Definition Origin of edema Respiratory failure not due to cardiac failure or fluid overload Exclude hydrostatic edema if no risk factor present
• Oxygenation Mild
Signs/Symptoms
Hypoxemia Productive cough Pleuritic chest pain Temperature 38.3°C or
