WORLD PHARMACY AND PHARMACEUTICAL SCIENCES Gupta et al. JOURNAL OFWorld Journal of Pharmacy and Pharmaceutical Sciences SJIF Impact Factor 6.041

Volume 5, Issue 4, 2325-2334

Research Article

ISSN 2278 – 4357

COMPARATIVE IN-VITRO PHARMACEUTICAL QUALITY CONTROL EVALUATIONS OF DIFFERENT BRANDS OF IBUPROFEN TABLETS MARKETED IN THE TRINIDAD & TOBAGO, WEST INDIES Madan Mohan Gupta*1 and Madhulika Gupta2 1

School of Pharmacy, Faculty of Medical Sciences, The University of The West Indies, St. Augustine, Trinidad & Tobago, WI. 2

Statistical Consultant, Aranguez, San Juan, Trinidad & Tobago, WI.

Article Received on 22 Feb 2016,

ABSTRACT Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) that is

Revised on 12 March 2016, Accepted on 03 April 2016

commonly used for the relief of symptoms of arthritis, fever, primary

DOI: 10.20959/wjpps20164-6571

dysmenorrhea (menstrual pains) and as an analgesic (a medication given to reduce pain without resulting in loss of consciousness). The

*Corresponding Author

purpose of this research work was to check, compare and evaluate the

Dr. Madan Mohan

quality standards as per the pharmacopoeia of different brands of

Gupta

Ibuprofen tablet of 400mg strength available in hospitals and

School of Pharmacy,

pharmacies of Trinidad & Tobago. These different brands (A, B, C, D)

Faculty of Medical

of Ibuprofen tablets were tested for weight variation, friability,

Sciences, The University of The West Indies, St.

disintegration, drug assay and in-vitro dissolution. The evaluation

Augustine, Trinidad &

study was performed as per the United States Pharmacopoeia. The

Tobago, WI.

results shows that all the tablets passed the uniformity of weight (