VITTORIA FLAMINI CONTACT INFORMATION

Department of Mechanical and Aerospace Engineering NYU Polytechnic School of Engineering 6 MetroTech Center Brooklyn, NY 11201

RESEARCH INTERESTS

Cardiovascular Biomechanics, Magnetic Resonance Imaging, Patient-Specific Modeling, Multiscale Modeling of Biological Tissues, Drug Delivery, Medical Devices

ACADEMIC POSITIONS

Industry Assistant Professor, July 2013 to present Department of Mechanical and Aerospace Engineering, NYU Polytechnic School of Engineering, Brooklyn, NY

Phone: +1 718 260 4122 Mobile: +1 646 269 9556 Email: [email protected] Website: wp.nyu.edu/vflamini

Post Doctoral Fellow, March 2011 to July 2013 Department of Mechanical and Aerospace Engineering, NYU Polytechnic School of Engineering, Brooklyn, NY - Mentor: Prof. Boyce E. Griffith - Area of Study: Cardiovascular Fluid Mechanics, Immersed Boundary Method EDUCATION

Ph.D. in Biomedical Engineering, March 2011 Dublin City University (DCU), Dublin, Ireland - Thesis Title: “Mechanical Characterisation of Porcine Aorta Using Magnetic Resonance Imaging” - Advisor: Dr. Caitríona Lally - Area of Study: Cardiovascular Biomechanics, Medical Imaging M.Sc. in Medical Engineering, May 2006 Università degli Studi di Roma Tor Vergata, Rome, Italy - Area of Study: Cardiovascular Biomechanics, Medical Devices B.Eng. in Medical Engineering, November 2003 Università degli Studi di Roma “Tor Vergata”, Rome, Italy

AWARDS

2014

Biomedical Engineering Innovation and Career Development Award, Biomedical Engineering Society (BMES), BMES Annual Meeting, San Antonio (TX)

2012

Prize winner at IMechE Republic of Ireland Young Engineers Research Paper, awarded by Engineers in Ireland, Institution of Mechanical Engineers

2009

Honorable mention at ASME Summer Bioengineering Conference, Lake Tahoe (CA), PhD Level Best Paper Award, Podium competition in the Tissue and Cell Biomechanics & Imaging category

2008

First place at Symposium for Mechanical Engineering Research and Practice, Dublin City University (Ireland), podium presentation Second place at Sir Bernard Crossland Symposium Postgraduate Workshop, University of Limerick (Ireland), poster presentation

COLLABORATORS

Matteo Aureli (University of Nevada, Reno), Leon Axel (New York University), Puneet Bhatla (New York University), Alesha B. Castillo (New York University), Abe DeAnda (New York University), Boyce E. Griffith (University of North Carolina, Chapel Hill), Christian M. Kerskens (Trinity College Dublin), Caitríona Lally (Dublin City University), Achiau Ludomirsky (New York University), Lawrence Scotten (ViVitro® Systems Inc.), Cíaran K. Simms (Trinity College Dublin), Omar Tanweer, (New York University), Giuseppe Vairo (Università degli Studi di Roma “Tor Vergata”)

PEER REVIEWED PUBLICATIONS

SUBMITTED PUBLICATIONS

CONFERENCE PROCEEDINGS

1.

Flamini, V., Creane, A.P., Kerskens, C.M., Lally, C. 2015. Imaging and Finite Element Analysis: A Methodology for Non Invasive Characterization of Aortic Tissue. Medical Engineering and Physics, 37(1):48-54.

2.

Griffith, B.E., Flamini, V., DeAnda, A., Scotten, L. 2013. Simulating the Dynamics of an Aortic Valve Prosthesis in a Pulse Duplicator: Numerical Methods and Initial Experience. Journal of Medical Devices, 7(4), 040912.

3.

Maddalo, S.L., Ward, A., Flamini, V., Griffith, B.E., Ursomanno, P., DeAnda, A. 2013. Antihypertensive Strategies in the Management of Aortic Disease. Journal of the American College of Surgeons, 217(3):S39.

4.

Flamini, V., Kerskens, C.M., Lally, C. 2013. Fibre Orientation of Fresh & Frozen Porcine Aorta Determined Non-Invasively Using Diffusion Tensor Imaging. Medical Engineering and Physics, 35(6), 765-776.

5.

Flamini, V., Kerskens, C.M., Moerman, K.M., Simms, C.K., Lally, C. 2010. Imaging Arterial Fibres Using Diffusion Tensor Imaging – Feasibility Study and Preliminary Results. EURASIP Journal on Advances in Signal Processing, 2010:904091.

6.

Moerman, K.M., Kerskens, C.M., Lally, C., Flamini, V., Simms, C.K. 2010. Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation. EURASIP Journal on Advances in Signal Processing, 2010:942131.

7.

Flamini, V., Kerskens, C.M., Lally, C. 2008. Characterization of the 3D Fibre Distribution in a Porcine Aorta Using Diffusion Tensor Imaging. Journal of Biomechanics, 41(1), S69.

1.

Creane, A.P., Flamini, V., Kerskens, C.M., Lally, C. Collagen Fibre Architecture in Arterial Bifurcations; Novel Techniques for In-vitro Measurement and In-silico Prediction of Fibre Patterns. Medical Image Analysis, submitted for publication.

2.

Flamini, V., DeAnda, A., Griffith, B.E. Prestressed Fluid Structure Interaction of the Aortic Root. International Journal for Numerical Methods in Biomedical Engineering, submitted for publication.

3.

Bhagavatula, S., Chung, S., Flamini, V., Kim, K.E., Axel, L. Noninvasive Liver Stiffness Assessment Using Tagged MRI and Inverse Finite Element Modeling of Cardiac-induced Hepatic Motion. Journal of Biomechanics, submitted for publication.

4.

Maddalo, S., Ward, A., Beller, J., Scheinerman, J., Flamini, V., Griffith, B.E., Ursomanno, P., DeAnda, A., Prediction of the Interaction of Aortic Wall Stress and Anti-hypertensive Medications, Journal of the American College of Surgeons, submitted for publication.

1. Flamini, V., DeAnda, A., Griffith, B.E. 2013. Simulating the effects of intersubject variability in aortic root compliance by the immersed boundary method. In P. Nithiarasu, R. Lohner, and K. M. Liew, editors, Proceedings of the Third International Conference on Computational & Mathematical Biomedical Engineering. 2. Dottori, S., Flamini, V., Maceri, F., Vairo, G. 2006. Analisi del Comportamento Biomeccanico di Stent: un Approccio agli Elementi Finiti. AIAS, XXXV convegno nazionale, Università Politecnica delle Marche.

INVITED TALKS

1. Flamini, V. 2014, Including Residual Stress and Initial Strain in an Asymmetric Model of the Aortic Root, International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE), Special Session: In vivo Characterization of the Physical Properties of Living Tissues, October 14th, 2014, Amsterdam, The Netherlands. 2. Flamini, V. 2014, Including Initial Strain in an Asymmetric Model of the Aortic Root, World Congress of Computational Mechanics (WCCM XI), Minisymposium: Computational Multiscale Methods for Tissue Biomechanics, July 24th, 2014, Barcelona, Spain. 3. Flamini, V. 2014, Patient-specific Models of the Aorta: Structure, Function, and Pathophysiology, Seminar, New Jersey Institute of Technology, February 12th, 2014, Newark, NJ. 4. Flamini, V. 2009. DTI Applied to Porcine Aortas: Analysis of 3D Fibrous Structure. IDIG Research Day (Irish Diffusion Imaging Group), December 11th, 2009, Galway, Ireland.

CONFERENCE PRESENTATIONS

1. Griffith, B.E., DeAnda, A., Flamini, V., Holzapfel, G., McQueen, D.M., Peskin, C.S. 2014. Simulating the Dynamics of Aortic Dissection. WCB 2014, July 6-11, 2014, Boston, MA. 2. Flamini, V., Griffith, B.E., DeAnda, A. 2014. Including Residual Stress and Initial Strain in Dynamic Fluid-Structure Interaction Models of the Aortic Root. WCB 2014, July 6-11, 2014, Boston, MA. 3. Griffith, B.E., Flamini, V., DeAnda, A., Scotten L. 2013. Simulating the Dynamics of an Aortic Valve Prosthesis in a Pulse Duplicator : Numerical Method and Initial Experience. ASME/FDA 2013 1st Annual Frontiers in Medical Devices : Applications of Computer Modeling and Simulation, September 11-13, 2013, Washington, DC. 4. Creane, A.P., Flamini, V., Kerskens, C.M., Lally, C. 2013. Arterial Fibre Characterization in a Bovine Bifurcating Artery Using Non-Invasive Diffusion Tensor Imaging and a Finite Element Based Fibre Remodelling Algorithm. 19th Annual Conference of the Bioengineering Section of the Royal Academy of Medicine in Ireland, January 18-19, 2013, Enfield, Co. Meath, Ireland. 5. Flamini, V., DeAnda, A., Griffith, B.E. 2012. Modeling Aortic Dissection Using ihe Immersed Boundary Method. World Congress Computational Mechanics, July 8-13, 2012, San Paolo, Brazil. 6. Flamini, V., Kerskens, C.M., Lally, C. 2011. Determination of Arterial Tissue Mechanical Properties: a Non Invasive Approach. 17th Annual Conference of the Section of the Royal Academy of Medicine in Ireland, January 28-29, Galway, Ireland. 7. Flamini, V., Kerskens, C.M., Lally, C. 2010. Determination of Aortic Tissue Mechanical Properties Combining Magnetic Resonance Imaging and Finite Element Modelling. ISSEC & Irish Mechanics Society Meeting (Irish Society for Scientific and Engineering Computation), May 20th, 2010, University College Dublin, Dublin, Ireland. 8. Flamini, V., Kerskens, C.M., Lally, C. 2010. In Vivo Determination of Aortic Tissue Mechanical Properties Using Magnetic Resonance Imaging (MRI): A Feasibility Study. 16th Annual Conference of the Section of the Royal Academy of Medicine in Ireland, January 22-23, 2010, Malahide, Co. Dublin, Ireland. 9. Flamini, V., Kerskens, C.M., Lally, C. 2009. An Anisotropic Structural Model of the Aortic Wall Based on Tensile Tests and Non-Invasive 3D Fibre Analysis Using Diffusion Tensor Imaging. ASME Summer Bioengineering Conference, June 17-21,

2009, Lake Tahoe, CA. 10. Flamini, V., Kerskens, C.M., Lally, C. 2009. An Anisotropic Aortic Constitutive Model Based on 3D Non-Invasive Fibre Analysis and Tensile Testing. 15th Annual Conference of the Section of the Royal Academy of Medicine in Ireland, January 3031, 2009, Limerick, Ireland. 11. Lally, C., Flamini, V., Kerskens, C.M., Creane, A.P., Kelly, D., Hynes, N., Sultan, S. 2008. Preclinical Medical Device Testing and the Potential of Non-Invasive Imaging. 6th Annual Western Vascular Symposium, May 20th, 2008, Galway, Ireland. 12. Flamini, V., Kerskens, C.M., Lally, C. 2008. Effects of Tractography Parameters on the 3D Fibre Distribution of a Porcine Aorta, Symposium for Mechanical Engineering Research and Practice. May 10th, 2008, Dublin City University, Dublin, Ireland. CONFERENCE POSTERS

1. Bhatla, P., Chakravarti, S., Ludomirsky, A., Argilla, M., Berman, P., McElhinney, D., Flamini, V. 2015 Patient-Specific Simulation of Right Ventricle Outflow Tract Conduit Balloon Angioplasty Using Cardiac MRI-Derived 3D Virtual Models to Assess the Risk of Coronary Artery Compression During Transcatheter Pulmonary Valve Replacement, accepted to ACC Scientific Sessions, 2015, March 14-16, San Diego, CA. 2. Ward, A., Maddalo, S., Gallot-Lavallée, S., Flamini, V., DeAnda, A., Griffith, B.E. 2014. Influence of Anti-hypertensive Medications on Aortic Peak Stress. AHA Scientific Sessions, November 15-19, 2014, Chicago, IL. 3. Lucienne, Z.P., Flamini, V., Ursomanno, P., DeAnda, A., Griffith, B.E. 2014. Methods for Patient-specific Aortic Dissection Modelling. BMES 2014 Annual Meeting, October 23-25 2014, San Antonio, TX. 4. Chaves-Carvalho, F., Flamini, V., Bhagavatula, S., Chung, S., Axel, L. 2014. Noninvasive Characterization of Liver Stiffness Based on Tagged MRI and Inverse Finite Element Analysis. BMES 2014 Annual Meeting, October 23-25 2014, San Antonio, TX. 5. Creane, A.P., Kerskens, C.M., Flamini, V., Lally, C. 2014. Fibre Characterisation in an Arterial Bifurcation using Non-Invasive Diffusion Tensor Imaging and Finite Element Based Fibre Remodelling. WCB 2014, July 6-11, 2014, Boston, MA. 6. Griffith, B.E., Flamini, V., DeAnda, A. 2013. Fluid-Structure Interaction Model of Aortic Dissection Driven by Fluid Forcing. BMES 2013 Annual Meeting, September 25-28, 2013, Seattle, WA. 7. Flamini, V., Griffith, B.E. 2013. Prestressed Fluid-Structure Interaction Model of the Aortic Root. BMES 2013 Annual Meeting, September 25-28, 2013, Seattle, WA. 8. Flamini, V., Griffith, B.E. 2013. Optimal Constitutive Parameters and Subject Specific Variability: an Application to the Aortic Sinuses. ASME 2013 Summer Bioengineering Conference, June 25-29, 2013, Sunriver, OR. 9. Bhagavatula, S., Chung, S., Flamini, V., Kim, K.E., Park, M.S., Axel, L. 2012. Noninvasive Liver Stiffness Assessment Using Tagged MRI: A Finite Element Model Approach. Radiological Society of North America, November 25-30, 2012, Chicago, IL. 10. Flamini, V., Kerskens, C.M., Lally, C. 2010. Aortic Constitutive Model Determined from Diffusion Tensor Imaging. IDIG Spring Symposium (Irish Diffusion Imaging Group), April 26th, 2010, Royal College of Physicians, Dublin Ireland. 11. Flamini, V., Kerskens, C.M., Lally, C. 2008. 3D Fibre Distribution in a Porcine Aorta Using Diffusion Tensor Imaging. Sir Bernard Crossland Symposium. March 12-13, 2008, University of Limerick, Limerick, Ireland.

PATENTS

Tanweer, O., Flamini, V., 2014, Drug-Eluting Stent and Method, US. Patent Application 14/444,251, filed July 2014, Patent Pending.

ACTIVE GRANTS

1. Patient-Specific Simulation of Right Ventricle Outflow Tract Conduit Balloon Angioplasty Using Cardiac MRI-Derived 3D Virtual Models to Assess the Risk of Coronary Artery Compression During Transcatheter Pulmonary Valve Replacement. KiDS of NYU. Funded ($ 15,000). Duration: 2015-2016. Role: Collaborator. 2. Development of a Distal Drug Delivery Stent System. NYU Applied Research Support Fund. Funded ($ 50,000). Duration: 2015-2015. Role: Principal Investigator.

GRANTS UNDER REVIEW

1. Bioinspired Fractal Vasculatures: a Multiscale Platform for Physiological Fluid Dynamics and Transport Phenomena. NSF solicitation 14-511. Submitted. Role: Principal Investigator. 2. Development of a Minimally Invasive, Patient-specific, Intracranial Drug-Delivery Device for the Treatment of Metastatic Breast Cancer. Avon Foundation. Submitted. Role: Principal Investigator.

OTHER GRANTS

1. Mathematical Modeling and Computer Simulation of Aortic Dissection. NIH solicitation PAR-09-218. Funded. Duration: 2013-2018. Role: Investigator. 2. Mathematical Modeling and Computer Simulation of the Aortic Valve in Health and Disease. American Heart Association. Scientist Development Grant. Funded. Duration: 2010-2014. Role: Investigator.

TEACHING EXPERIENCE

NYU Polytechnic School of Engineering, Brooklyn, NY - ME-UY 3223 Dynamics, from Spring 2012 to Spring 2014. - ME-UY 4214 Finite Element Modeling, Design and Analysis, Fall 2014 - ME-GY 5103 Biofluids, Spring 2015 Dublin City University, Dublin, Ireland - MM498 Rehabilitation Engineering, from Spring 2008 to Spring 2010. MM105 Professional & Personal Skills - Engineering, from Spring 2007 to Spring 2008.

MENTORING EXPERIENCE

NYU Polytechnic School of Engineering, Brooklyn, NY - ME997X Master’s Thesis in Mechanical Engineering, Syed M. Thamid, M.Sc. 2014, (Fluid-structure interaction model of the ViVitro Systems Inc. pulse duplicator system). Simon Gallot Lavallée, M.Sc. 2014, (Framework for the numerical analysis of aortic dissecton). Andrew Lynch, M.Sc. 2015, (Development of an MRI-compatible spirometer). Ali I. Alherz, expected M.Sc. 2015, (Mechanical characterization of dual stents). - Science and Mechatronics Aided Research for Teachers (SMART) 2011. - Undergraduate students Divya Agarwal, B.Sc. 2013, (Modeling the aortic leaflet). Hussein Saab, B.Sc. 2011, (Modeling the variability of the material properties of the aortic wall). - Graduate students Asif Yeahia, M.Sc. 2013, (Generation of a 3D model of the ViVitro®

SERVICE

Systems Inc. pulse duplicator system). - Undergraduate Summer Research: Fréderico Chaves Carvalho, expected B.Sc. 2015, (Non-Invasive analysis of liver stiffness). Zed P. Lucienne, expected M.Sc. 2016, (On an automatic method for patient-specific segmentation of dissected aortas pre and post-surgery). Dublin City University, Dublin, Ireland - INTRA undergraduate research project in Biomedical Engineering, 2007-08. Reviewer: - PLOS ONE, Journal of Biomechanics, Journal of Mechanical Behavior of Biomedical Materials, Biomechanics and Modeling in Mechanobiology, Journal of Applied Mathematics. - Grant reviewer for the Italian Ministry of Health. - Abstract reviewer for: ASME Summer Bioengineering Conference, BMES Annual Conference. ASME Committees: - Education Committee of the Bioengineering Division of ASME, Committee for the ASME BED Award in Biomedical Engineering Education. - Honors Committee of the Bioengineering Division of ASME, Judge for the PhD-level podium competition in the Imaging category. NYU Polytechnic School of Engineering, Department of Mechanical and Aerospace Engineering: - Undergraduate Program Strategic Implementation Plan. New York University, - Mentor, Women in Science (WINS) Initiative. - Faculty Advisor, Society of Women Engineers (SWE) NYU-PSoE chapter. - Talk: Understanding the Heartbeat: Studying the Aortic Valve. NYU-Poly Women’s Summit, March 13th, 2013, Brooklyn, NY.

PROFESSIONAL ACTIVITIES

Member of the Entrepreneurial Scientist Advisory Panel at NYC-Tech Connect since July 2013, New York, NY.

AFFILIATIONS

Society of Women Engineers, since 2013. American Society of Mechanical Engineers, since 2012. Biomedical Engineering Society, since 2011. European Society of Biomechanics, since 2007. Registered Engineer in Italy since 2007.

ADDITIONAL PROFESSIONAL TRAINING

2010

2009 2008 2006

Course on Nonlinear Elasticity with Applications in Biomechanics, held by Professor R.W. Ogden FRS, School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Dublin, Ireland. Training Course in Intellectual Property & Commercialization, organized by DCU Business School and Invent, Dublin City University, Dublin, Ireland Postgraduate Tutor/Demonstrator Course, organized by DCU’s Learning Innovation Unit, Dublin City University, Dublin, Ireland Summer School on Mechanical & Structural Engineering for Postgraduate Students, School of Engineering and Computer Science, Durham University, Durham, UK

COMPUTER SKILLS LANGUAGES

MATLAB, LabVIEW, ABAQUS, ANSYS, Python, Osirix, MedINRIA, ImageJ, MRIcron, LaTeX, OriginLab, Linux -

Italian: Native speaker English: Fluent speaker French: Intermediate speaker Spanish: Pre-Intermediate speaker