Visual Field Constriction in 91 Finnish Children Treated with Vigabatrin

Epilepsia, 43(7):748–756, 2002 Blackwell Publishing, Inc. © International League Against Epilepsy Visual Field Constriction in 91 Finnish Children Tr...
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Epilepsia, 43(7):748–756, 2002 Blackwell Publishing, Inc. © International League Against Epilepsy

Visual Field Constriction in 91 Finnish Children Treated with Vigabatrin *Sampsa Vanhatalo, †Iiris Nousiainen, ‡Kai Eriksson, §Heikki Rantala, §Leena Vainionpa¨a¨, ¨ a¨rimaa, ††Reija Alen, ‡‡Marjo-Riitta Aine, §§Roger Byring, ¶Kirsi Mustonen, **Tuula A 㛳㛳 Aune Hirvasniemi, ¶¶Auli Nuutila, ***Tiina Walden, †††Ulla-Maija Ritanen-Mohammed, §§§Pirkko Karttunen-Lewandowski, 㛳㛳㛳Leena-Maria Pohjola, ¶¶¶Satu Kaksonen, ****Pekka Jurvelin, and *Marja-Liisa Granstro¨m *Unit of Child Neurology, Hospital for Children and Adolescents, University Hospital of Helsinki, Helsinki; †Department of Ophthalmology, Kuopio University Hospital, Kuopio; ‡Pediatric Neurology Unit, Tampere University Hospital and Medical School, University of Tampere, Tampere; §Department of Pediatrics, University of Oulu, Oulu; ¶Department of Child Neurology, North Karelian Central Hospital, Joensuu; **Unit of Neuropaediatrics, University Central Hospital of Turku, Turku; ††Department of Child Neurology, Central Hospital of Central Finland, Jyva¨skyla¨; ‡‡Department of Child Neurology, Lapland Central Hospital, Rovaniemi; §§Department of Child Neurology, Central Hospital of Vaasa, Vaasa; 㛳㛳Department of Pediatrics, Kainuu Central Hospital, Kajaani; ¶¶Central Hospital of South Ostrobothnia, Department of Pediatrics, Unit for Pediatric Neurology, Seina¨joki; ***Department of Child Neurology, Central Hospital of Kymenlaakso, Kotka; †††Department of Pediatrics, Central Hospital of Pa¨ija¨t-Hame, Lahti; §§§Department of Pediatrics, Mikkeli Central Hospital, Mikkeli; 㛳㛳㛳 Department of Pediatrics, South Carelian Central Hospital, Lappeenranta; ¶¶¶Department of Pediatrics, District Hospital of Western Nyland, Ekena¨s; ****Department of Pediatrics, Central Hospital of La¨nsi-Pohja District, Kemi, Finland

Summary: Purpose: To study the prevalence and features of visual field constrictions (VFCs) associated with vigabatrin (VGB) in children. Methods: A systematic collection of all children with any history of VGB treatment in fifteen Finnish neuropediatric units was performed, and children were included after being able to cooperate reliably in repeated visual field tests by Goldmann kinetic perimetry. This inclusion criterion yielded 91 children (45 boys; 46 girls) between ages 5.6 and 17.9 years. Visual field extent 70 degrees in the temporal meridian; (b) mildly abnormal, if the fields extended from 50 to 70 degrees in the temporal meridian; and (c) severely abnormal, if the fields extended

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