VCA: HAND, FACE and BEYOND

VCA: HAND, FACE and BEYOND Thursday, November 3, 2016 PLENARY SESSION I: 12:30 PM - 12:45 PM Gold Coast Room Opening Ceremony W. P. Andrew Lee, MD, A...
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VCA: HAND, FACE and BEYOND Thursday, November 3, 2016 PLENARY SESSION I: 12:30 PM - 12:45 PM Gold Coast Room

Opening Ceremony W. P. Andrew Lee, MD, ASRT President Bohdan Pomahac, MD, Program Co-Chair Damon Cooney, MD, PhD, Program Co-Chair

12:45 PM – 2:45 PM Gold Coast Room

Genital Reproductive Transplantation Uterus/Penile Moderator: Stefan Tullius, MD Clinical Amir Zarrabi, MD; University of Stellenbosch, Cape Town Mats Brännström, MD; University of Gothenburg Andreas Tzakis, MD; Cleveland Clinic Curt Cetrulo, MD; Massachusetts General Hospital Ethical Amir Zarrabi, MD; University of Stellenbosch, Cape Town Ana Iltis, PhD; Wake Forest University

2:45 PM – 3:15 PM French Room

Break with Exhibitors

3:15 PM – 5:45 PM Gold Coast Room

Speed Round: Update of all Active International Centers Moderator: Damon Cooney, MD, PhD

Cleveland (Frank Papay, MD) MGH (Curtis Cetrulo, MD) BWH (Bohdan Pomahac, MD) Lyon (Palmina Petruzzo, MD) Paris (Laurent Lantieri, MD) Wroclaw (Jerzy Jablecki, MD) Johns Hopkins/ UPMC (Jaimie Shores, MD) Louisville (Christina Kaufman, PhD) UCLA (Kodi Azari, MD) Duke (Linda Cendales, MD) UPenn (L. Scott Levin, MD) Wilford Hall (Dmitry Tuder, MD) 6:30 PM – 8:00 PM Grand Ballroom

Munich (Christof Hoehnke, MD) Turkey (Omer Ozkan, MD) Maryland (Rolf Barth, MD) NYU (Ed Rodriguez, MD, DDS) University of Stellenbosch Cape Town (Amir Zarrabi, MD) University of Gothenburg (Prof. Mats Brännström) Finland (Patrik Lassus, MD) Taiwan (Yu Ren Kuo, MD) Toronto (Heather Baltzer, MD)

Wine and Cheese Reception with Exhibitors

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VCA: HAND, FACE and BEYOND Friday, November 4, 2016 PLENARY SESSION II: 6:30 AM – 7:30 AM French Room

Breakfast

7:00 AM – 7:50 AM Gold Coast Room

UNOS/OPTN/HRSA Oversight Moderators: Sue McDiarmid, MD; Linda Cendales, MD Results of a Survey of Organ Procurement Organizations to Identify Barriers to VCA Authorization and Recovery in the US Wida Cherikh, Ph.D., Ann Harper, M.P.H., Richard Luskin, M.P.A., Christopher Wholley, M.S.A, Sue McDiarmid, M.D. Upcoming UNOS Reporting Requirements for Programs Sue McDiarmid, MD HRSA and VCA: Moving from Experimentation to Standard of Care Melissa Greenwald, MD

7:50 AM – 8:45 AM Gold Coast Room

AST Presidential Update: Anil Chandraker, MD, AST President “Recent Advancements in Transplantation”

8:45 AM – 9:45 AM Gold Coast Room

Keynote Address: Megan Sykes, MD “Durable Mixed Chimerism – An Achievable Goal?”

9:45 AM – 10:15 AM French Room

Break with Exhibitors

PLENARY SESSION III: 10:15 AM – 12:15 PM Gold Coast Room

Immunology/Immunotherapy Moderators: Gerald Brandacher, MD; Curt Cetrulo, MD Panel: Immunotherapy Protocols Currently in Use Panelists: Emmanuel Morelon, MD; Gerald Brandachar, MD; Leo Riella, MD; Christina Kaufman, PhD Discussion of Immune Monitoring Leo Riella, MD; Giorgio Raimondi, MD

12:15 PM – 1:00 PM French Room

Lunch with Exhibitors

12:15 PM – 1:00 PM Drake Room

Business Meeting (ASRT Members Only)

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VCA: HAND, FACE and BEYOND PLENARY SESSION IV: 1:00 PM – 2:00 PM Gold Coast Room

New Ways to Approach VCA: Lessons to be learned from Industry Innovation Panelists: Wendy Dean, MD; Simon Talbot, MD Discussant: L. Scott Levin, MD, FACS

2:00 PM – 2:30 PM French Room

Break with Exhibitors

2:30 PM – 4:00 PM

Concurrent Interactive Workshops

Venetian Room (2nd Floor)

Therapists Forum Chairs: Gayle Severance, MS, OT/L, CHT; Ashley Emrich, MS, OTR/L, CHT Unique Challenges Specific to the Pediatric Recipient – Children’s Hospital of Philadelphia Presenters: Deb Humpl, OTR/L; Todd Levy, MS, OTR/L; Michelle Hsia, MS, OTR/L; Kelly Ferry, MOT, OTR/L Therapy Following Trans-Humeral UE Transplantation – The Johns Hopkins Experience Presenter: Heather Meguire, OTR/L, CHT Functional Recovery in the Unilateral Hand Transplant Patient – Toronto Experience Presenter: Teresa Wesolowski, PT, CHT Panel: Hand Transplant Candidate Selection and Rehabilitation Challenges Moderators: Gayle Severance MS, OT/L, CHT; Ashley Emrich, MS, OTR/L, CHT

Drake Room

Transplant Coordinators Forum Chairs: Kate Knott, NP; Lisa Quinn Brief Updates from Participating Centers John Hopkins Hospital (Kate Knott, NP) Brigham and Women’s Hospital, Boston (Lisa Quinn) University of Michigan (Mable Glass, RN, BSN) UCLA (Kate Knott, NP on behalf of Erin Core) Toronto General Hospital (Robyn Beechey RN, BScN) Mayo Clinic (Lynette Fix, RN) UPENN (Christine McAndrew, PA-C) BWH’s Experience with Insurance Coverage of Post-Transplant Medications & Long Term Follow up Care Presenter: Lisa Quinn

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VCA: HAND, FACE and BEYOND 2:30 PM – 4:00 PM Gold Coast Room

Paper Session: Clinical VCA & General Moderators: Jaimie Shores, MD; Christina Kaufman, PhD; Matthew Carty, MD

2:30 PM - 2:35 PM Near Normothermic Ex-situ Perfusion Extends Human Limb Allograft Survival Up to 24 Hours Kagan Ozer, MD, Nicole Werner, MD, Fares Alghanem, BS, Stephanie L. Rakestraw, BS, Dylan Sarver, BS, Bruce Nicely, RN, MSN, Richard Pietroski, MS, Paul Lange, MD, Steve M. Rudich, MD, PhD, Chris L. Mendias, PhD, Alvaro Rojas-Pena, MD, John C. Magee, MD, Robert H. Bartlett, MD Abstract Page 26 2:35 PM - 2:40 PM In Vivo Evaluation of the Retina and Optic Nerve after Whole Eye Transplantation Using Optical Coherence Tomography and Manganese-Enhanced Magnetic Resonance Imaging Chiaki Komatsu, M.D., Lin He, MD, Yolandi van der Merwe, BEng, Maxine Miller, MD, Katie Lucy, BS, Huamin Tang, MD, Ian Rosner, BS, Yang Li, M.D., Ph.D., Gadi Wollstein, M.D., Mario G. Solari, MD, Joel S. Schuman, MD, Kevin C. Chan, PhD, Kia M. Washington, MD Abstract Page 27 2:40 PM - 2:45 PM Long-Term Functional and Anatomic Outcomes on The World’s First Vascularized Orthotopic Rodent Whole Eye Transplant Kia M. Washington, MD; Lin He, MD, Chiaki Komatsu, M.D., Yang Li, M.D., Ph.D., Maxine Miller, MD, Yolandi van der Merwe, BEng, Katie Lucy, BS, Huamin Tang, MD, Ian Rosner, BS, Hongkun Wang, Mario G. Solari, MD, Gadi Wollstein, M.D., Joel S. Schuman, MD, Kevin C. Chan, PhD, Abstract Page 28 2:45 PM - 2:50 PM The International Registry on Hand and Composite Tissue Allotransplantation (IRHCTT) Palmina Petruzzo, MD, Prof, Jean Michel Dubernard, Marco Lanzetta, MD, Prof Abstract Page 29 2:50 PM - 2:55 PM Molecular Signature of Acute Rejection in Facial Allograft Biopsies Thet Su Win, MD, PhD, Jessica Teague, Harriet Kiwanuka, Nicco Krezdorn, Ericka Bueno, Leonardo Riella, Rachael Clark, Bohdan Pomahac, Rachel Lopdrup Abstract Page 30 2:55 PM - 3:00 PM

Discussion

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VCA: HAND, FACE and BEYOND 3:00 PM - 3:05 PM Vascularized Composite Allograft Tolerance with Transient High-Dose Tacrolimus across a Full MHC Mismatch in a Large Animal Model Angelo Leto Barone, MD; Howard D. Wang, MD, Edward W. Swanson, MD, Hsu-Tang Cheng, MD, Jeffrey Walch, MD, PhD, Jose C. Alonso-Escalante, MD, Keli Kolegraff, MD, PhD, Joseph Lopez, MD, MBA, Georg Furtmuller, MD, Byoung Chol Oh, DVM, PhD, Amy Quan, MPH, Joshua Budihardjo, Sara AlFadil, MD, Sara Mulla, MD, Samuel Fidder, MD, Paul Akre, MS, Justin M. Sacks, MD, Steven C. Bonawitz, MD, Giorgio Raimondi, PhD, Jaimie T. Shores, MD, Damon S. Cooney, MD, PhD, W. P. Andrew Lee, MD, Gerald Brandacher, MD Abstract Page 32 3:05 PM - 3:10 PM Tolerance Induction to Vascularized Composite Allografts by Costimulation Blockade Byoung Chol Oh, DVM, PhD, Georg Furtmuller, MD, Madeline Fryer, BS, Johanna Grahammer, Stefan Schneeberger, Damon Cooney, MD, PhD, W. P. Andrew Lee, MD, Giorgio Raimondi, Ph.D, Gerald Brandacher, MD Abstract Page 33 3:10 PM - 3:15 PM Acute Skin Rejection in Non-Human Primate Models of Face and Hand Allotransplantation: Before and After Tolerance Induction Curtis L. Cetrulo Jr, MD, FACS, FAAP, Zhi Yang Ng, MD, Matthew W. Defazio, BS, Harrison Powell, BS, David A. Leonard, MD, PhD, Zachary W. Heroux, BS, Alexandre G. Lellouch, MD, Ilse Schol, BS, Josef M. Kurtz, PhD Abstract Page 34 3:15 PM - 3:20 PM Experience with Patient Referrals and Patient Recruitment in Face and Upper Extremity Harriet Kiwanuka, BA, Mario A. Aycart, M.D., Ericka M. Bueno, PhD, Muayyad Alhefzi, MD, Nicco Krezdorn, MD, Simon Talbot, MD, Bohdan Pomahac, M.D. Abstract Page 35 3:20 PM - 3:25 PM Towards Tolerance of Facial Allotransplantation: Preliminary Results in A Non-Human Primate Model with Tocilizumab Curtis L. Cetrulo Jr, MD, FACS, FAAP, Zhi Yang Ng, MD, Alexandre G. Lellouch, MD, Matthew W. Defazio, BS, Zachary W. Heroux, BS, Ilse Schol, BS, Josef M. Kurtz, PhD Abstract Page 36 3:25 PM - 3:30 PM

Discussion

3:30 PM - 3:35 PM Localized Immunosuppression in Vascular Composite Allotransplantation Using Hydrogel Drug Delivery System Dzhuliya Dzhonova, PhD, Adriano Taddeo, Radu Olariu, Jonathan Leckenby, Ashish Dhayani, Praveen Vemula, Esther Voegelin, Robert Rieben Abstract Page 37

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VCA: HAND, FACE and BEYOND 3:35 PM - 3:40 PM Improved Vascularized Composite Allograft Survival in Sensitized Rats after Syngeneic Hematopoietic Stem Cell Transplantation and Fludarabine Gerald Brandacher, MD; Howard D. Wang, MD, Samuel Fidder, MD, Devin Miller, MD, Georg Furtmuller, MD, Denver M. Lough, MD, PhD, Joseph Lopez, MD, MBA, Amy Quan, MPH, Joshua Budihardjo, Giorgio Raimondi, PhD, Zhaoli Sun, MD, PhD, W. P. Andrew Lee, MD Abstract Page 38 3:40 PM - 3:45 PM Locally Implantable Biodegradable Polymeric Tacrolimus Disc Prolongs Survival of Vascularized Composite Allografts without Morbid Adverse Effects Firuz Gamal Feturi, B.Pharm., PhD, Jignesh V. Unadkat, Vasil Ercument Erbas, MD, Liwei M. Dong, MD, Wensheng Zhang, Vijay Gorantla, M.D., Ph.D., Mario G. Solari, MD, Raman Venkataramanan, PhD, Alexander Marcus Spiess Abstract Page 39 3:45 PM - 3:50 PM Bone Marrow Regulated Local Protective Mechanisms of Vascularized Composite Allografts in Non-Human Primates Mehmet C. Uluer, MD, ScM, Arthur J. Nam, Jhade D. Woodall, MD, Wessam Hassanein, MD, David A. Bruno, MD, Dawn Parsell, BS, Urmil Drhu, BS, Branko Bojovic, Stephen T. Bartlett, MD, Rolf N. Barth, MD Abstract Page 40 3:50 PM - 3:55 PM Vascularized Composite Allotransplantation Combined With Donor Bone Marrow and Post Transplantation High-Dose Cyclophosphamide (Ptcy) Induces Immune Tolerance after Reconstructive Transplantation Byoung Chol Oh, DVM, PhD, Georg J. Furtmueller, M.D., Madeline Fryer, B.S., Jeffrey Dodd-o, M.D., Ph.D., Sudipto Ganguly, Ph.D., Giorgio Raimondi, Ph.D, Damon Cooney, MD, PhD, W. P. Andrew Lee, MD, Leo Luznik, M.D., Gerald Brandacher, MD Abstract Page 41 3:55 PM - 4:00 PM

Discussion

4:00 PM – 4:30 PM

Break with Exhibitors

PLENARY SESSION V: 4:30 PM – 5:30 PM Gold Coast Room

Panel: The Barriers and Opportunities in VCA Moderator: Sue McDiarmid, MD OPO Challenges Alexandra Glazier Principles of Responsible Surgical Innovation Nancy Ascher, MD

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VCA: HAND, FACE and BEYOND 5:30 PM – 6:00 PM Gold Coast Room

Best Paper Session

5:30 PM - 5:36 PM Mentor Introduction: Gerald Brandcher, MD Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts Byoung Chol Oh, DVM, PhD, Georg Furtmuller, MD, Marcos Iglesias, Ph.D., Madeline Fryer, BS, Giorgio Raimondi, Ph.D, Damon Cooney, MD, PhD, W. P. Andrew Lee, MD, Gerald Brandacher, MD Abstract Page 42 5:36 PM - 5:42 PM Mentor Introduction: Bohdan Pomahac, MD The Role of Skin Resident Donor T Cells in Face Transplant Rejection Thet Su Win, MD, PhD, Jessica Teague, Elizabeth Lowry, Harriet Kiwanuka, Nicco Krezdorn, David Hamm, Ericka Bueno, Rachael Clark, Bohdan Pomahac Abstract Page 43 5:42 PM - 5:48 PM Mentor Introduction: Stefan Schneeberger, MD De Novo Donor-Specific HLA Antibodies after Combined Intestinal and Vascularized Composite Allotransplantation: A Single Centre Experience Annemarie Weissenbacher, MD, Georgios Vrakas, Mian Chen, Srikanth Reddy, Susan Fuggle, Peter Friend Abstract Page 45 5:48 PM - 5:58 PM

Discussion

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VCA: HAND, FACE and BEYOND Saturday, November 5, 2016 6:30 AM – 7:30 AM French Room

Breakfast

7:00 AM - 8:15 AM Drake Room

Transplant Psychiatrists/Psychologists Forum Chair: Elisa Moreno, MD Update on Second International Chauvet Conference 2016: Psychiatric issues in VCA Palmina Petruzzo, MD Ethical Considerations in Face Transplantation Elisa Moreno, MD Psychiatric issues in Hand versus Face Transplantation Christian Seulin, MD

7:00 AM – 8:15 AM Gold Coast Room

Paper Session: Basic Science & General Moderators: Mario Solari, MD; Justin Sacks, MD; Vijay Gorantla, MD

7:00 AM - 7:05 AM Molecular Analogy between Cellular and Antibody-Mediated Rejection in Clinical Face Transplantation Thet Su Win, MD, PhD, Naoka Murakami, Harriet Kiwanuka, Nicco Krezdorn, Ericka Bueno, Rachael Clark, Rachel Lopdrup, Leonardo Riella, Bohdan Pomahac Abstract Page 46 7:05 AM - 7:10 AM Software Based Video Analysis of Functional Outcomes of Face Transplantation Sebastian Fischer, M.D., Nico Krezdorn, Anne Huang, Muayyad Alhefzi, Mario A. Aycart, Harriet Kiwanuka, Yannick Diehm, Thet S. Win, Ericka M. Bueno, Bohdan Pomahac Abstract Page 48 7:10 AM - 7:15 AM Type-1 Interferon Counters the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance Marcos Iglesias Lozano, DVM, PhD, Anirudh Arun, BS, Brandon Lam, BS, W. P. Andrew Lee, MD, Gerald Brandacher, MD, Giorgio Raimondi, Ph.D Abstract Page 49 7:15 AM - 7:20 AM Non-Contrast Enhanced 7 Tesla MR Imaging for Non-Invasive Monitoring Of Chronic Rejection in Reconstructive Transplantation Vijay S. Gorantla, MD, PhD, Shailesh Raval, MS, Tiejun Zhao Tiejun Zhao, Ph.D., Narayan Krishnamurthy, Tamer Ibrahim, Ph.D Abstract Page 50

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VCA: HAND, FACE and BEYOND 7:20 AM - 7:25 AM Ex Vivo Hypothermic Perfusion of Amputated Porcine Forelimbs Promotes Reduced Molecular Damage to Skeletal Muscle When Compared With Conventional Cold Storage Nicco Krezdorn, Dharaniya Sakthivel, Mario A. Aycart, M.D., Muayyad Alfhefzi, Thet-Su Win, Harriet Kiwanuka, Ericka Bueno, Indranil Sinha, Bohdan Pomahac Abstract Page 52 7:25 AM - 7:30 AM Optimization of a Differential Cytokine Profile-Based Non-Invasive Diagnostic and Predictive Tool for Reliable Diagnosis of Acute Rejection in VCA Piul S. Rabbani, PhD, Rohini L. Rabbani, M.D., Nakul Rao, Chin Park, Daniel Ceradini Abstract Page 53 7:30 AM - 7:35 AM

Discussion

7:35 AM - 7:40 AM Exosomes from Mesenchymal Stem Cells Package Anti-Inflammatory Cytokines in Allotransplantation Jonathan P. Massie, BS, Yohei M. Rosen, J. Rodrigo Diaz-Siso, Natalie M Plana, Daniel J Ceradini Abstract Page 54 7:40 AM - 7:45 AM Heterotopic Rat Penis Transplantation: A Novel Microsurgical Model to Study Distinct Immunologic Features of Urogenital Tissues in the Setting of Reconstructive Transplantation Samuel A.J. Fidder, B.S., Georg J. Furtmueller, M.D., Byoung Chol Oh, DVM, PhD, Barbara Kern, M.D., Denver M. Lough, MD, PhD, W. P. Andrew Lee, MD, Damon S. Cooney, M.D., Ph.D., Richard J. Redett, M.D., Gerald Brandacher, M.D. Abstract Page 55 7:45 AM - 7:50 AM Belatacept in Hand Transplantation - Effectiveness and Pitfalls Johanna Grahammer, Bettina Zelger, Prof., MD., Bernhard Zelger, Annelies Muehlbacher, M.D., Dietmar Oefner, Ao.Univ.-Prof., Stefan Schneeberger, Annemarie Weissenbacher, MD Abstract Page 56 7:50 AM - 7:55 AM Dynamics and Correlates of Skin Dendritic Cells with Distinctive Immune Response Profiles in Vascularized Composite Allografts Wensheng Zhang, MD, PhD, Chiaki Komatsu, M.D., Firuz Gamal Feturi, B.Pharm., PhD, Lin He, MD, Liwei Dong, Jiaqing Wu, MD, PhD, Maxine Reedy Miller, MD, Jeffrey Mark Walch, MD/PhD, Student, Alicia Mathers, PhD, Angus W. Thomson, Kia M. Washington, MD, Vijay Gorantla, Mario Solari Abstract Page 57 7:55 AM - 8:00 AM The Biomechanisms of Adipose-Derived Stem Cells Modulated Dendritic Cell Activation Yur-Ren Kuo, MD, PhD, Ching-Ming Chien, Yu-Chi Wang Abstract Page 58

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VCA: HAND, FACE and BEYOND 8:00 AM - 8:05 AM In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells - A Novel Strategy to Induce Tolerance in Transplantation Ewa Bryndza Tfaily, PhD, Malgorzata Cyran, MD, Rafal Gendek, MD, PhD, Erzsebet Szilagyi, MD, PhD, Jason Le, MD, Anna Domaszewska-Szostek, PhD, Joanna Cwykiel, MSc, Maria Siemionow, MD, PhD, DSc Abstract Page 59 8:05 AM - 8:10 AM

Discussion

PLENARY SESSION VI: 8:15 AM – 9:15 AM Gold Coast Room

Infectious Disease – VCA vs. Other Organ Transplants Francisco Marty, MD; Cameron Wolfe, MD

9:15 AM – 10:15 AM Gold Coast Room

Panel: Funding Mechanisms; Paying for the Future of VCA Moderator: L. Scott Levin, MD, FACS Panelists: Steven McCabe, MD; Carisa M. Cooney, MPH, CCRP; Emmanuel Morelon, MD; L. Scott Levin, MD, FACS; Wendy Dean, MD

10:15 AM– 10:45 AM French Room

Break with Exhibitors

10:45 AM –11:45 AM Gold Coast Room

Panel: Rejection: Classification, Mechanisms, and Markers Moderator: Christina Kaufman, PhD; Rolf Barth, MD Panelists: Christina Kaufman, PhD; Jean Kanitakis, MD; George Murphy, MD

11:45 AM – 12:15pm Gold Coast Room

Presidential Address: W. P. Andrew Lee, MD “How Interprofessional Collaboration Can Advance the Field of VCA”

12:15pm – 1:00pm French Room

Lunch Break

PLENARY SESSION VII 1:00pm – 2:00pm Gold Coast Room

Melina Nakos Symposium: Susan Mackinnon, MD “Nerve Research”

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VCA: HAND, FACE and BEYOND 2:00pm – 3:00 PM Gold Coast Room

VCA Controversies Moderators: Jaimie Shores, MD; Kodi Azari, MD Living Related Bohdan Pomahac, MD Combined SOT/VCA Transplantation Jesse Selber, MD Pediatric Transplantation Ronald Zuker, MD; L. Scott Levin, MD, FACS

3:00 PM – 3:15 PM French Room

Break with Exhibitors

3:15 PM – 4:00 PM Gold Coast Room

President-Elect Address: Sue McDiarmid, MD “Unexpected Common Ground: Pediatric Liver Transplant and VCA”

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VCA: HAND, FACE and BEYOND Posters Elbow Vascularized Composite Allotransplantation - Surgical Anatomy and Technique Zvi Steinberger, MD, Heng Xu, Nikolas H. Kazmers, Stephanie Thibaudeau, Russel G. Huffman, Lawrence S. Levin Abstract Page 60 Chimeric Cell Transplant for the Treatment of Duchenne Muscular Dystrophy Erzsebet Szilagyi, Joanna Cwykiel, Anna Domaszewska-Szostek, Maria Siemionow, MD, PhD, DSc Abstract Page 63 Cervical lymph node transplantation model in rats Safak Uygur, Joanna Cwykiel, Can Ozturk, Mehmet Bozkurt, Grzegorz Kwiecien, Maria Madajka, Maria Siemionow Abstract Page 64 Belatacept and Rapamycin in a novel large animal vascularized composite allotransplantation model delays graft rejection Matthias Waldner, MD, Wensheng Zhang, M.D., Ph.D., Anton Fries, MD, Shari D. Lawson, MD, Michael Davis, MD, Alan F. Zahorchak, MS, Mohamed B. Ezzelarab, MD, Vijay S. Gorantla, MD, PhD, Angus W. Thomson, PhD, Mario G. Solari, MD Abstract Page 65 Clinical Application of Mathematical Long Bone Ratios to Calculate Appropriate Donor Limb Lengths in Bilateral Upper Limb Transplantations Justyn Lutfy, MDCM, Alexis Pietak, B.Sc, B.Sc., Eng, Ph.D, Shaun D. Mendenhall, MD, Michael W. Neumeister, MD Abstract Page 66 Evaulation of Physiological Dynamics after Whole Eye Transplantation Maxine R. Miller, MD, Yang Li, MD, PhD, Chiaki Komatsu, MD, Lin He, MD, Yolandi van der Merwe, BEng, Hongkun Wang, MD, Bo Wang, PhD, Edward H. Davidson, MA, (Cantab.), MBBS, Mario G. Solari, MD, Shuzhong Guo, MD, PhD, Valeria Fu, PhD, Gadi Wollstein, MD, Joel S. Schuman, MD, Kevin C. Chan, PhD, Kia M. Washington, MD Abstract Page 67 A Novel Bioresorbable/Biointegratable/Biocompatible Dressing for Negative Pressure Wound Therapy Kevin Wu, R Cindass, SD Lawson, VS Gorantla, MR Davis Abstract Page 68 The Effect of Size Discrepancy of Human Nerve Allograft Derived Epineural Conduit on the Functional Outcomes of Nerve Regeneration in Athymic Nude Rat Model Marcin Strojny, Rafal Gendek, Joanna Cwykiel, Erzsebet Szilagyi, Malgorzata Cyran, Wojciech Malewski, Husein Karagoz, Maria Siemionow Abstract Page 69

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VCA: HAND, FACE and BEYOND Assessment of Engraftment and Safety of a New Tolerance Inducing Therapy of Human Cord Blood Derived Ex-vivo Created Di- Chimeric Cells in NOD SCID Mouse Model Joanna Cwykiel, MSc, Natalia Filipek, BSc, Malgorzata Cyran, Can Emre Bas, Erzsebet Szilagyi, Ewa Bryndza Tfaily, Medhat Askar, MD, PhD, Maria Siemionow Abstract Page 70 Axonal Repair as a New Paradigm for Nerve Coaptation Peter William Henderson, MD, MBA Abstract Page 71 Graft-Implanted Tacrolimus-Eluting Hydrogels Prolong Survival after Vascularized Composite Allotransplantation Kevin Wu, MR Davis, VS Gorantla, SD Lawson, R Cindass, J. Karp, P. Vemula, A. Dhayani, K. Slaughter, N. Joshi Abstract Page 72 Ex-vivo Graft Preservation with Hydrogen Sulfide and Hydrogen Iodide for Suspended Animation of Non-Human Primate (Macaca mulatta) Upper Extremity Vascularized Composite Allotransplants (VCA) Kevin Wu, MR Davis, M Roth, SD Lawson, R Cindass, JR Spencer Abstract Page 73 Possible Accommodation in a Bilateral Transhumeral Transplant Pedro C. Cavadas, Alessandro Thione Abstract Page 74 Establishing a Novel Surgical Model for Optic Nerve Repair Cagri Cakmakoglu, MD, Bahar Bassiri Gharb, MD, PhD, Antonio Rampazzo, MD, PhD, Grzegorz Kwiecien, MD, Maria Madajka, PhD, Addison Barnett, BS and Francis Papay, MD Abstract Page 75 Outcomes of Solid Organ Transplants Following Simultaneous Solid Organ and Vascularized Composite Allograft Procurements: A Nationwide Analysis Mario A Aycart, MD, Muayyad Alhefzi, MD, Gaurav Sharma, MD, Nicco Krezdorn, MD, Ericka M Bueno, PhD, Simon G Talbot, MD, Matthew J Carty, MD, Stefan G Tullius, MD, PhD and Bohdan Pomahac, MD Abstract Page 77 Total Human Eye Allotransplantation (THEA): Protocol Optimization of Imaging Modalities in a Non-Human Primate Model Edward H Davidson, MA, (Cantab), MBBS, Jonathan Carney, Brian Lopresti, Maxine Reedy Miller, MD and Kia M Washington Abstract Page 78

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VCA: HAND, FACE and BEYOND The First Hand Allotransplantation in Taiwan? Progress Report on 18 Months Yur-Ren Kuo, MD, PhD, Chien-Chang Chen, Yen-Chou Chen and Jui-Kun Chang, MS Abstract Page 79 Face Transplantation and the Reconstructive Management of the Self-Inflicted Gunshot Wound: An Aesthetic, Functional, and Psychosocial Report of Six Clinical Cases Harriet Kiwanuka, Mario A Aycart, MD, David Gitlin, MD, Elaine Devine, LICSW, Bridget Perry, MS, Thet Su Win, MD, PhD, Ericka M Bueno, Muayyad Alhefzi and Bohdan Pomahac, MD Abstract Page 80 Next Generation Quantitative Sequencing for Detecting Chimerism in a NHP Model Jhade D Woodall, MD, Mehmet C Uluer, MD, ScM, Matthew Chrencik, Arthur J Nam, MD, Stephen T Bartlett, MD and Rolf N Barth, MD Abstract Page 82 Vascular Anatomy of Facial Units for Vascularized Composite Tissue Transplantation Design in a Large Animal Model: An In-vivo and Radiological Study Marissa Suchyta, BA, Anita Mohan, MRCS, MBBS, Basel Sharaf, MD, DDS, Karim Bakri, MBBS, Saad Alsubaie, MD, Gregory Michalak, PhD and Samir Mardini, MD Abstract Page 83 Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves Upper Extremity Murine Function Joseph Lopez, MD, MBA, Amy Quan, Joshua Budihardjo, Kim Sinan, Howard Wang, Chris Cashman, Ahmet Hoke, Sami Tuffaha, WP Andrew Lee and Gerald Brandacher Abstract Page 84 Applications of Virtual Surgical Planning and Computer 3D Modeling in Face Transplantation Marissa Suchyta, BA, Anita Mohan, MRCS, MBBS, Basel Sharaf, MD, DDS, Karim Bakri, MBBS, Jorys Martinez-Jorge, MD, Uldis Bite, MD and Samir Mardini, MD Abstract Page 85 Facial Transplantation Outcomes; Comprehensive Analysis of Risks and Benefits Muayyad Alhefzi, Mario A Aycart, Harriet Kiwanuka, Nicco Krezdorn, Thet Su Win, Ericka M Bueno and Bohdan Pomahac Abstract Page 86

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VCA: HAND, FACE and BEYOND Novel Approaches to Assessment of Facial Nerve Regeneration in a Swine Hemi-facial Composite Tissue Flap Model: A physiological and histological study Marissa Suchyta, BA, Anita Mohan, MRCS, MBBS, Saad Alsubaie, MD, James Schmelzer, CAP, Karim Bakri, MBBS, Basel Sharaf, MD, DDS, Chunfeng Zhao, MD, Eric Sorenson, MD, Phillip Low, MD, Peter Dyck, MD and Samir Mardini, MD Abstract Page 87 Hand Transplantation in Patients with Extensive Burns of the Upper Extremities: Anatomical Study of the Feasibility Edoardo Dalla Pozza, MD, Bahar Bassiri Gharb, MD, PhD, Andrew Steckler, MS, Francis Papay, MD and Antonio Rampazzo, MD, PhD Abstract Page 88 A Volumetric Analysis of Potential Tissue Burden for Lower Extremity Vascularized Composite Allotransplantation Matthew J Carty, MD, Simon G Talbot, MD, Stephen Ledbetter, MD, MPH and Seth Levine Abstract Page 89 Blood Transfusion Is Not Necessarily a Sensitizing Event Precluding Transplantation Jeffrey W Aston, BS, Kate P Knott, CRNP, Damon S Cooney, Gedge D Rosson, Ricardo J Bello, W P Andrew Lee, Jaimie T Shores, Gerald Brandacher and Carisa M Cooney Abstract Page 90

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