US Centers for Disease Control and. Construction Services Design Leader

R a n dy K r ay, Aia Senior Vice President | Science + Technology Director of Programming and Planning Randy Kray has over 20 years of specialized a...
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R a n dy K r ay,

Aia

Senior Vice President | Science + Technology Director of Programming and Planning Randy Kray has over 20 years of specialized architectural experience in strategic planning, programming, and design of scientific facilities. He is a strategic leader in HOK’s Science + Technology group, and a leading expert in the design of highly complex scientific facilities, including labs in high containment biosafety facilities, animal facilities, nanotechnology facilities, and other interdisciplinary academic and governement research facilities. As a recognized global thought leader on high containment facility design and the integration E d u c at i o n

University of Manitoba Masters of Architecture , 1993 University of Manitoba Bachelor of Environmental Science, 1989 P r o f e s s i o n a l Reg i s t r at i o n s

Architecture: Georgia, Manitoba, Ontario (submitted) M em b e r s h i p s

American Institute of Architecture American Biological Safety Association (ABSA) European Biological Safety Association European Research Infrastructure on Highly Pathogenic Agents (ERINHA) American Association for Laboratory Animal Science (AALAS)

of design/construction/commissioning delivery systems for complex science and technology missions, he is a frequent speaker at scientific conferences. He regularly published articles on these subjects and has contributed to both national and international design and safety standards, including the latest CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition. Experience

US Centers for Disease Control and

National Institutes of Health

Prevention

NIAID Integrated Research Facility*

Emerging Infectious Diseases Laboratory*

Fort Detrick, Maryland

Atlanta, Georgia

Role: Principal Planner and Containment

Role: Containment Planner and Architect,

Architect. New 144,000 gsf high

Construction Services Design Leader

containment research & analysis facility

(BSL-4/BSL-3E areas). New 440,000 gsf

that includes 25,000 sf BSL-4 laboratory

infectious disease research facility and

and animal facility, BSL-2 laboratories, and

central energy plant on the CDC’s Atlanta

research support areas. This BSL-4 facility is

campus. The facility includes approximately

the first to provide fully-integratedadvanced

20,000 square feet of BSL-4/3enhanced

medical equipment, patient support

space, organized into four multi-pathogen

infrastructure, and whole-animal imaging

and multi-program suites. BSL-2 and BSL-3

in an ABSL- 4 environment, including MRI,

diagnostics laboratories and BSL-3 animal

PET/CT, SPECT/CT and X-ray fluoroscopy

facility.

modalities.

US Centers for Disease Control and

US Army Medical Research Institute

Prevention

of Infectious Diseases (USAMRIID)

NCID/DVBID Replacement Laboratory*

Replacement Facility *

Fort Collins, Colorado

Fort Detrick, Maryland

Role: Containment lab and vivarium planner.

Role: Principal Lab Planner. Development

New replacement laboratory facility for

of Design Brief, Master Planning Study and

the CDC in Fort Collins, Colorado jointly

Design/Construction services for a new

houses the National Center for Infectious

Biodefense Campus at Ft. Detrick. Phased

Diseases (NCID) and Division of Vector-

implementation of 835,390 gsf of new

Borne Infectious Diseases (DVBID). The

Biomedical Research and Testing Facilities

building consists of offices, BSL-2 and BSL-3

that include offices, BSL2, BSL3, and

laboratories and their associated support

BSL4 laboratories for infectious diseases

labs; small animal BSL-3 vivarium space; and

and toxicology, animal facilities and related

an BSL-3 insectary. A feature of this project

infrastructure. The state-of-the art facility

is a 25,000 gsf BSL-3 insectary, which is

will significantly increasing laboratory and

highly integrated with the laboratory and

vivarium research capabilities for BSL-2,

animal research components.

BSL-3E and BSL-4 biomedical and clinical research.

* experience prior to joining HOK

h o k .c o m

R a n dy K r ay,

AIA

S p ea k i n g E n g a g eme n t s

Experience

“Achieving Sustainability in High

National Biotechnology Centers for

University of Florida

Performance Buildings” Open Buildings

Advanced Product Development (NBCAPD)

Communicore BSL-3 Animal

Conference - Architecture in the Fourth

Medical Countermeasure T&E Facility*

Facility Renovation*

Dimension, Boston MA (2011)

Fort Detrick, Maryland

Gainesville, Florida

“The Art and Science of Biocontainment

Role: Lab Planner and Biocontainment

Role: Containment Lab Planner NIH funded

Expert. Development of space program

renovation and remodeling of 55,333 sf

(Brief) and Master Planning study for a new

in the Communicore Animal Care Facility,

inter-agency animal Testing and Evaluation

including expanding the ABSL-3 suite and

(T&E) facility for biodefense and infectious

providing approximately 5,000 sf of flexible

disease countermeasure development

lab space.

Facility Design, Construction and Operation,” American Biological Safety Association Meeting, Anaheim, CA (2011) “Commissioning & Validation for Laboratory Waste Autoclaves,” International Veterinary Biosafety Workgroup General Meeting, Copenhagen, Denmark (2011) “Agriculture Pathogens: Planning, Design and Operational Strategies,” Canadian Biosafety Symposium, Toronto, Ontario, Canada (2011) “Defining user Requirements for BSL4 Facilities - What does the architect need to know,” ERINHA (European Research Infrastructure on Highly Pathogenic Agents) Workshop 4.1, Lyon, France (2011) “Nanotechnology Safety: Applying Prevention through Design Principles to Nanotechnology Facilities,” Institute of Environmental Sciences and Technology (IEST), Working Group WG-CC205 Workshop, Chicago, IL (2011)

at the Ft. Detrick biodefense campus. The facility is programmed to provide

Tulane University

approximately 460,000 GSF of ABSL-2,

National Primate Center,

ABSL-3, and ABSL-4 GLP animal testing

Regional Bio-Containment Lab*

space and support space to validate new

Covington, Louisiana

biodefense and emerging infectious disease

Role: Containment Lab Planner. 2,166gm²

countermeasures under the new FDA Animal

BSL-3 bio-containment, vivarium and

Rule.

laboratory for the NIH. His role was biocontainment designer responsible for

New York State Department of Health,

the development, protocol-to-planning

Wadsworth Centre*

coordination, & documentation of the

Albany, New York

aerobiology lab, including the primary

Role: Principal Planner. The planning study of

containment equipment & integration into

a new 23,225gm² of laboratory facilities on

ABSL-3.

multiple sites and site selection services for a new high containment facility.

Lovelace Respiratory Research Institute ABSL3 Facility Expansion*

The Qualification Process Adapted to

University of Florida

Albuquerque, New Mexico

Containment Facility Design and Delivery,”

Pathogen Research Facility*

Role: Principal Lab Planner. 4,000 sf

The International Centre for Infectious

Gainesville, Florida

enhanced ABSL-3 facility expansion.

Diseases (ICID), Canadian Biosafety

Role: Containment Lab Planner. This 10,000

The facility is to include additional animal

Symposium, Winnipeg, Canada (2010)

square meter Pathogen Research Facility

housing rooms, laboratories, procedure

“Current Best Practices for Influenza

(PRF), home of the Emerging Pathogens

room and freezer/refrigerator room. The

Institute, will integrate disciplines that

existing supporting infrastructure, such as

have not traditionally collaborated at the

steam sterilization, change/shower rooms,

Research and Diagnostic Facilities - Risk, Safety and Design,” Tradeline International Conference on Biocontainment Facilities, St. Petersburg, Florida (2010) “Biocontainment Design and Risk Assessment Safety System Integrity Approaches and Practice,” CDC International Symposium on Biosafety, BSL-4 Users

University of Florida to attack problems

effluent decontamination system (EDS),

of emerging and re-emerging pathogens.

PPE decontamination, etc will be used to

Project include BSL-2 (QC2/PC2), BSL-3

support the new space. It is anticipated that

(QC3/PC3) laboratory, animal and plant

the majority of the new construction will be

growth space, bioinformatics, and BSL-2

performed while the current facility is fully

(PC2) and BSL-3 (PC3) greenhouses.

operational.

Group, Atlanta, GA USA (2009)

4 LEED Certified * experience prior to joining HOK

h o k .c o m

R a n dy K r ay,

AIA

S p ea k i n g E n g a g eme n t s

Experience

“Risk-based Planning for Leading-Edge

4 University of California

Bioscience Research Centre*

Work Environments and Future Changes in

Western National Bio-defense and Emerging

Melbourne, Australia

Safety Protocols,” Tradeline International

Disease Research Facility*

Role: Principal Containment Planner.

Conference on Biocontainment Facilities,

Davis, California

Containment architect and laboratory

Washington, DC (2008)

Role: Principal Planner. Programming

planners for a Public Private Partnership (P3)

“Imaging and biocontainment – A single

for a 3,251nm² BSL 4 Laboratory. Co-

design and construction team. The project

authored original UC Davis Feasibility

was sponsored by a joint venture between

Report, completed prior to NIAID NBL

the Government of Victoria and La Trobe

program announcement. Participated in

University in Australia. The total net area of

user interviews; developed original planning

14,660 M2 included physical containment

concepts for BSL4/BSL3- Ag laboratory

level 2 (PC2) and level 3 (PC3) laboratories,

and animal spaces based on bio-defense

small animal vivarium, plant research

research needs. Retooled original program

laboratory/greenhouses and large animal

based on stated NIAID bio-defense

post-mortem space.

equipment platform for clinical, research, and outbreak-readiness,” Tradeline International Conference on Biocontainment Facilities, Washington, DC (2008) “New Technologies in Containment Facilities” CDC International Symposium on Biosafety, Atlanta, GA (2008) “Core Issues in Retrofitting an Existing Facility” CDC International Symposium on

strategies and FDA drug development guidelines (current and draft); acted as peer

Pirbright Site Redevelopment Programme*

reviewer for development of functional

Pirbright, United Kingdom

concept diagrams, blocking and stacking

Role: Principal Planner and Containment

diagrams based on master plan concepts,

Architect, Commissioning and Validation

development of fully functional concept

Consultant. A new 140,000 sf containment

plans incorporating diagrammatic concepts.

level 4 facility for the UK Institute for

Collaborator and contributor to rooms

Animal Health at Pirbright. The redeveloped

layout drawings for clinical research, basic

Pirbright site will include the construction

BSL2 laboratories, BSL3/BSL4/BSL3-Ag

of a new laboratory building, gatehouse

laboratories, ABSL3 and ABSL4 animal

and energy centre, and new landscape

“Ideas of Planning Safely in Academic

holding, aerobiology and ABSL2 animal

and infrastructure works. The facility is

Laboratory Design” University Safety &

support spaces.

designed to allow flexible multi-program

Biosafety, Atlanta, GA (2008) “Design of ABSL 1-4 Animal Facilities” CDC International Symposium on Biosafety, Atlanta, GA USA(2008) “Installing Flexible Film Isolators to Satisfy Changing Regulations Cost-Effectively with Minimal Disruption to Research” American Biological Safety Association Meeting, Reno, NV.USA(2008)

research and reference laboratory work with

Health Association (USHA), London, UK (2008)

University of California

a broad spectrum of viruses of veterinary

“Multi-Pathogen, Multi-Protocol Facility

CNSI BSL-3 Laboratory*

significance including Foot and Mouth

Los Angeles, California

Disease (world reference lab), Blue Tongue,

Role: Project Director and Principal

Newcastle Disease, and emerging zoonotic

Planner. 6,500 sf core and shell fit-out to

diseases. The facility is designed to meet

provide an enhanced BSL-3 laboratory for

the UK SAPO (veterinary) Level 4 and

high throughput robotic diagnostics and

ACDP (human health) Level 3 containment

sample repository. Main components of the

requirements, and will comply with the new

program are an open flexible multi-station

UK single human/animal/GMO regulatory

automation laboratory and a million sample

framework. The main lab building features

automated biobank system, operating under

a highly evolved containment strategy

USDA enhanced BSL-3 protocols. BSL-2

– both physical containment and work

and BSL-3 laboratories and equipment

management systems – to minimize the

control/observation rooms support the high

impact of containment separation and allow

throughput logistics requirements.

the maximum staff interaction without

Design Solutions” Tradeline International Conference on Biocontainment Facilities, San Diego, California (2007) “Optimization of High Containment Secondary Barrier Performance and Proportionate Site Validation Methods” American Biological Safety Association Meeting, Nashville Tenn. (2007) “Overview of Lessons Learned in Europe, Asia and the Americas” Eagleson Institute International Biocontainment Design Colloquium, Freeport, Maine. (2007) “Integration of Imaging Equipment and Other

compromise to safety and security.

New Technologies into Biocontainment

University of Saskatchewan

Facilities and Vivariums” Eagleson Institute International Biocontainment Design Colloquium, Freeport, Maine. (2007) * experience prior to joining HOK

h o k .c o m

R a n dy K r ay,

AIA

S p ea k i n g E n g a g eme n t s

Experience

“High Containment Fire Safety Design and

International Vaccine Centre (InterVac)*

Veterinary Lab Addition*

Approval Process for the Boston Medical

Saskatoon, Canada

Laramie Wyoming

University NEIDL” Eagleson Institute

Role: Principal Planner for Project Brief and

Role: Principal Containment Lab Planner

International Biocontainment Design

Concept Design. New 116,221 gsf large

and Architect. Design of a new addition

Colloquium, Freeport, Maine. (2007)

animal vaccine research and development

and renovations to existing facilities for the

“Flattening Biocontainment: An International

facility designed to meet Canadian

University of Wyoming, the Wyoming State

AP3LA (US BSL-3Ag) (QC3) containment

Veterinary Laboratory (WSVL) and Wyoming

requirements, with accompanying

Game & Fish Department – Wildlife Disease

Perspective of Trends in Containment” Annual Conference of the European Biosafety Association, Heidelberg, Germany (2007) “Vivaria without walls – The new animal housing solution” Tradeline’s Animal Research Facilities Conference, Hilton Head, South Carolina (2007) “Multi-modal, whole-animal, in vivo imaging inside a biocontainment environment”Tradeline’s Animal Research Facilities Conference, Hilton Head, South Carolina (2007) “Acceptable Air Leakage Criteria for Biocontainment Barriers” American Biological Safety Association Annual Conference, Boston, MA. (2006) “Fire Suppression Design Strategies for Boston University Medical Center National Emerging and Infectious Diseases Laboratory” International Veterinary Biosafety Working Group Conference,

containment level 3 (CL-3) research

Laboratory (WGFD-WDL). to modernize and

laboratories.

accommodate state animal health programs for endemic and emerging infectious disease

Imperial College

surveillance and diagnostics. The new

DEFRA 4 Feasibility Study*

addition and renovation includes BSL-2 and

London, United Kingdom

BSL-3 laboratories and post mortem areas

Role: Project Director and Principal Planner.

as well as support facilities to total 9,102 net

Feasibility and Masterplan services for

assignable square feet (NSF) / 20,730 gross

a new specialist teaching, research and

square feet (GSF). Construction completion

biology laboratory facility at Imperial

and building occupation in 2011.

College London’s School of Medicine. The facility includes 600 sq. m SAPO4 (QC-4)

University of Illinois at Chicago

and ACDP3 (PC-3) enhanced containment

National Centre for Bio-defense and

laboratories, ABSL3 vivarium, BSL3

Emerging Infectious Diseases, Facility

insectary, and electron microscopy suite. The

Feasibility Study*

scheme has been developed with Biosecurity,

Chicago, Illinois

Biosurety and Health and Safety as principle

Role: Principal Planner. Participation in

drivers as befits the complex nature of the

this project was in an overview role, mainly

scheme and its location.

responsible for the translation of UIC’s drug discovery and drug development

Emory University

expertise into an complete bio-defense

Yerkes National Primate Center, Dual

research program agenda, translated into

“Issues in Infectious Disease Research and

Function Primate Facility*

a functional program. Upon completion of

High Containment Facility Design” Mid-

Atlanta, Georgia

the functional program, involvement in the

Atlantic Bio Conference, Washington, DC

Role: Project Principal and Containment

project was mainly as a peer reviewer during

(2006)

Architect. Architecture, engineering and

the development of the design and costing

“One Step Beyond – The Next Measure in

commissioning peer review of 20,765 square

models.

Singapore (2006)

the Evolution of Biodefense. Infrastructure Requirements and Potential Impact on the Research Park” Association of University Research Parks (AURP) Annual Meeting, Atlanta, GA (2006) “Planning and Design Issues in High Containment Facilities” Eagleson Institute International Biocontainment Design Colloquium, London, UK (2006)

foot, $11 million ABSL-3/ABSL-2 nonhuman primate research facility. The facility

Parkville Comprehensive Cancer Centre*

incorporates two floors of primate research:

Melbourne, Australia

an ABSL3 Vivarium and infectious disease

Role: Project Director. Containment and

research floor with capacity for 108 animals;

healthcare planning for a Public Private

and a separate floor dedicated to the

Partnership (P3) design and construction

Transplant Medicine Facility with capacity for

team. The project involves the establishment

housing up to 80 animals in quarantine and

of a formal collaboration between Peter Mac

up to 168 NHPs post-transplant.

Hospital, the Royal Melbourne Hospital, the

Wyoming State University

University of Melbourne, the Melbourne

* experience prior to joining HOK

h o k .c o m

R a n dy K r ay,

AIA

S p ea k i n g E n g a g eme n t s

Experience

“BSL-3 and vivaria -- options for where the

branch of the Ludwig Institute for Cancer

University of Manitoba

barrier goes and the impact on operations

Research, the Royal Women’s Hospital and

Monsanto Crop Research Centre*

and costs” Tradeline International

the Walter and Eliza Hall Institute for Medical

Winnipeg, Canada

Conference on Biocontainment Facilities, St.

Research. The Total estimated Investment is

Role: Project Designer and Architect.

Petersburg, Florida (2005)

$1 billion. Total area 93,000 m2.

19,200 sq.ft. research facility included:

“Advanced Technologies in Containment” Eagleson Institute International Biocontainment Design Colloquium, Freeport, Maine (2005) “Lessons Learned in BSL3-Ag Facilities”Eagleson Institute International Biocontainment Design Colloquium, Freeport, Maine (2005) “Cost Effective Facility Design Strategies for Biocontainment Facilities Security” Tradeline International Conference on Biocontainment Facilities, St.Petersburg, Florida (2004) “Biocontainment Facility System Redundancy and the Quantification of Risk,” Tradeline International Conference on Biocontainment Facilities, St.Petersburg, Florida (2003)

BSL2 research laboratories, research office Texas Tech University

space, administrative offices and CL-2

Advanced Research Centre*

research green houses. Involved combination

Lubbock, Texas

of renovation of historical campus building

Role: Principal Planner. Member of the

and new construction. Design incorporates

team responsible for the development of

master planning for future expansion.

this Advanced Research Facility which includes a BSL- 4 laboratory for Texas Tech University. The project was designed in response to U.S government initiative to support academic research related to issues regarding and the inherent risk of infectious agents or chemicals being used as offensive weapons. It contains leading-edge technical detection, diagnostic and research systems. Undertaken in joint venture, the facility is approximately $98 million and completed in 2004.

p u b l i c at i o n s

“Perspectives in Biocontainment – Waste Matters” ALN Magazine, Vol. 10 No. 4. May/ June 2011 “Perspectives in Biocontainment – The Containment Barrier – Testing it Right, Part 2” ALN Magazine, Vol. 10 No. 2. March 2011 “Perspectives in Biocontainment – The Containment Barrier – Testing it Right, Part 1” ALN Magazine, Vol. 10 No. 1. January/ February 2011 “Perspectives in Biocontainment – Commitment to Containment” ALN Magazine, Vol. 9 No. 1. January 2010 “Perspectives in Biocontainment – The

University of Manitoba Agricultural and Food Sciences Building* Winnipeg, Canada Role: Principal Planner and Designer. New 7,500 sq. m agricultural teaching and research facility for the University of Manitoba, the facility includes: teaching laboratories, research laboratories, audiovisual and digital media classroom spaces with remote satellite broadcast capabilities, support spaces, administration offices and natural light filled meeting places for researchers and students.

BMBL 5th Edition: Model for Continuity and Change” ALN Magazine, Vol. 9 No. 2. March 2010 “Perspectives in Biocontainment – Simple Airflow Strategies Provide You the Greatest Reliability” ALN Magazine, Vol. 9 No. 3. April 2010 “Perspectives in Biocontainment – Pressure, Volume and Directional Airflow Objectives” ALN Magazine, Vol. 9 No. 5. July/August 2010

4 LEED Certified * experience prior to joining HOK

h o k .c o m

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