University of Toronto & InCor Cardiovascular Conference

5-6 Julho, 2013 Anfiteatro, Instituto do Coração InCor-HC.FMUSP

ATTENDEES University of Toronto

Michael E. Farkouh, MD, MSc The Director of the Heart and Stroke/ Richard Lewar Centre of Excellence in Cardiovascular Investigation and the Peter Munk Chair in Multinational Clinical Trials at the Peter Munk Cardiac Centre, University of Toronto. He is a graduate of the Schulich School of Medicine at Western University. Dr. Farkouh completed his internal medicine and cardiology training at the Mayo Clinic and the Icahn School of Medicine at Mount Sinai New York and holds an MSc in Clinical Epidemiology from McMaster University. He has published over 130 papers largely on acute coronary syndromes and cardiovascular prevention. He has mentored many fellows and is active in teaching clinical research methodology. Dr. Farkouh is internationally known for his work on the management of acute coronary syndromes in the emergency room. He has a special interest and expertise in the field of cardiovascular disease in diabetic patients. He is currently the project officer for numerous clinical trials on questions related to diabetes and heart disease including the NIH-sponsored FREEDOM trial and coordinates clinical studies in Grenada and Colombia. Dr. Farkouh has received the gold medal from John Paul II Hospital in Krakow and was the Teacher of the Year at the Mayo Clinic.

Mailing address:

Primary Office Peter Munk Cardiac Centre, University Health Network 585 University Avenue, Room 4N474 Toronto, Ontario M5G 2N2 [email protected]

Area of interest:

Prevention, Diabetes and Heart Disease

Conference:

Revascularization strategies for diabetic patients with CAD

Vlad Džavík, MD, FRCPC, FAHA

Mailing address: Primary Office Toronto General Hospital 6th Floor Rm. 248 200 Elizabeth St. Toronto, Ontario Canada M5G 2C4 [email protected]

A graduate of the Faculty of Medicine at the University of Alberta, Class of 1983. After completing his Cardiology and Interventional Cardiology training at the Ottawa Heart Institute in 1991, he joined the faculty at the University of Alberta. In 2000 he moved to Toronto where he served as Director of the Cardiac Catheterization Laboratories and Interventional Cardiology at the Peter Munk Cardiac Centre, University Health Network in Toronto for 11 years. Currently, he is now Deputy Head of the Division of Cardiology at the University Health Network and Mount Sinai Hospital, and Professor of Medicine at the University of Toronto. He continues to direct the research program in interventional cardiology. He has had an active research career, having authored or co-authored more than 160 manuscripts in peer-reviewed journals and more than 140 abstracts in national and international scientific meetings. His research interests range from percutaneous coronary intervention during and after acute myocardial infarction, study of optimal therapy for cardiogenic shock, outcomes in high-risk PCI. He was the Canadian Leader and Executive Committee member of the Occluded Artery Trial (OAT), an international collaboration studying the late open artery hypothesis, and serves as Principal Investigator of TOSCA-2, the OAT angiographic ancillary study, having received a National Institutes of Health (US) grant to conduct this study. He was also Principal Investigator of the international multicentre SHOCK-2 Phase 2 Trial of L-NMMA in cardiogenic shock, and Executive Committee Member and Canadian Country Leader of TRIUMPH, the subsequent phase 3 study. He is currently co-principal investigator of TOTAL, an international randomized trial of manual thrombectomy in patients with acute myocardial infarction undergoing primary PCI, and study chair of EMPRES a Canadian randomized trial of exenatide to improve heart function in also in patients undergoing primary PCI, that will begin enrolling patients shortly. Dr. Džavík is a member of the Editorial Board of the American Heart Journal and the Canadian Cardiology Journal, and a reviewer for Circulation, Journal of the American College of Cardiology, the American Journal of Cardiology, American Heart Journal, Critical Care Medicine and the European Heart Journal, the Canadian Journal of Cardiology, the International Journal of Cardiology and Eurointervention, as well as the Canadian Cardiovascular Congress, and the American College of Cardiology, American Heart Association and Transcatheter Cardiovascular Therapeutics Scientific Sessions. He has also played a leadership role in the Canadian Interventional Cardiology community, having served as President of the Canadian Association of Interventional Cardiology between 2005 and 2007.

Area of interest:

Interventional Cardiology and Acute Coronary Syndromes

Conference:

Advances in the interventional management of ACS

Bradley Strauss, M.D., Ph.D. Professor Department of Medicine, University of Toronto Laboratory Medicine and Pathobiology, University of Toronto Senior scientist, Molecular and cellular biology – Schulich heart research program, Sunnybrook Research Institute Reichmann Chair, cardiovascular sciences, Sunnybrook Health Sciences Centre and University of Toronto Director, Interventional cardiology research, Sunnybrook Health Sciences Centre

Mailing address: Primary Office Sunnybrook Health Sciences Centre 2075 Bayview Ave., Room A2 53 Toronto, ON M4N 3M5 email: [email protected]

Dr. Bradley Strauss has developed a novel approach to treating patients with blocked arteries. He has been experimenting with this application of collagenase since the 1990s. In addition to proving the enzymes are effective in softening plaque in coronary arteries, he has also produced a grade of collagenase safe for use in humans.

Area of interest:

Translational Research and Interventional Cardiology

Conference:

Pre-clinical and Clinical Research in Chronic Total Occlusions

Terrence M. Yau B.A., M.D., C.M., M.Sc., FRCSC Angelo and Lorenza DeGasperis Chair in Cardiovascular Surgery Research Director, Cardiac Stem Cell Therapy Program Director of Research, Division of Cardiovascular Surgery, Peter Munk Cardiac Centre Professor, Department of Surgery, University of Toronto Attending Cardiac Surgeon, Peter Munk Cardiac Centre at the University Health Network

Mailing address: Primary Office Toronto General Hospital University Health Network 200 Elizabeth St. Toronto, Ontario Canada M5G 2C4 [email protected]

Dr. Yau obtained his B.A. (Honors) from Johns Hopkins University in molecular biology prior to medical school at McGill University and his surgical training at the University of Toronto. In 1998 he joined the faculty of the Division of Cardiovascular Surgery at Toronto General Hospital. Since 1999, Dr. Yau has been the Director of Research in the division, and is also the holder of the Angelo and Lorenza DeGasperis Chair in Cardiovascular Surgery Research. He is a Professor in the Department of Surgery at the University of Toronto. Dr. Yau’s clinical interests include cardiac transplantation, mechanical circulatory support, perioperative blood conservation and cardiac intensive care. Dr. Yau conducts a number of clinical research protocols including studies of perioperative myocardial protection, cellular transplantation for advanced heart failure, and novel technology assessment in cardiac surgery. In addition, Dr. Yau runs a basic science laboratory with a focus in the combination of stem cell transplantation with gene therapy and transmyocardial revascularization, developing novel interventions for treatment of endstage heart failure. He has published extensively on a variety of clinical and basic science aspects of cardiac surgery.

Area of interest:

CT Surgery

Conference:

Stem cell therapy for myocardial repair

Heather J Ross, MD, MHSc, FRCP(C) Director of Cardiac Transplant Toronto General Hospital Heather Ross, MD, MHSc, FRCP (C), is a Professor of Medicine at the University of Toronto, and Director of the Cardiac Transplant Program at Toronto General Hospital. She is the Ted Rogers and Family Chair in Heart Function. She is the Head of the Ted Rogers Centre of Excellence in Heart Function and Director of Education for the University of Toronto Transplant Institute. She received her medical degree from the University of British Columbia, Canada, her cardiology training at Dalhousie University, and a postdoctoral fellowship in Cardiac Transplantation at Stanford University, California. She earned her Masters Degree in Bioethics from the University of Toronto. Dr. Ross served as the President of the Canadian Society of Transplantation in 2005, and an executive member of the International Society for Heart & Lung Transplantation from 2002 through 2005 and Secretary Treasurer 2007-2010. Since 2002, she has been a Supervisor for the CIHR Training Program in Regenerative Medicine, the Course Director since 2007 and Program Advisory Committee Chair and Co-Investigator from 2008. She Chaired the ISHLT Master Academy in Heart Failure in 2010. She was Associate Editor for the American Journal of Transplantation (2007-2010) and is an Associate Editor for the Journal of Heart and Lung Transplantation. She served 5 years on the Canadian Cardiovascular Society Council, 3 years on the Canadian Cardiovascular Society Executive and on the Board of the Canadian Cardiovascular Society Academy. She was the Secretary Treasurer for the Canadian Cardiovascular Society Academy 2010-2012. She is currently on the executive of the Heart Failure Society of America and the Vice President of the Canadian Cardiovascular Society. She has published over 200 articles and won numerous teaching awards.

Research interests:

Pharmacokinetic evaluation of immunosuppressive therapies Heart failure and transplantation

Conference:

End of Life Care in Heart Failure

Eric Horlick, MD CM, FRCPC, FSCAI An interventional cardiologist at the Peter Munk Cardiac Centre and an Associate Professor of Medicine at University of Toronto. His interests include percutaneous therapies for structural and congenital heart disease and percutaneous valve therapy. He has delivered over 300 lectures internationally since joining the Cardiology Division at PMCC in 2004. He has published over 70 peer reviewed papers and a number of book chapters. Dr Horlick performed the first percutaneous pulmonary valve implant in North America with Dr Lee Benson, the first percutaneous mitral valve repair in Canada, and the first transcatheter aortic valve in Toronto. He was intimately involved in the development of the Sapien pulmonary valve system and educated physicians all over Europe and the Middle East in the use of this new system. Dr Horlick has traveled extensively in North America, Europe and the Middle East to proctor and educate physicians in structural heart disease procedures. He has served on the program committee of several major international meetings, and is a Co-Chair of the American College of Cardiology Structural Heart Disease Program Committee. He has been involved in developing Canadian and International guidelines for Congenital Heart Disease and Percutaneous Valve Therapy.

Mailing address: Eric Horlick MDCM FRCPC, Director; Structural Heart Disease Intervention Program, Assistant Professor of Medicine, Peter Munk Cardiac Centre, Toronto General Hospital – University Health Network, Room 6E-249, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4. email: [email protected],k

Area of interest:

Structural Heart Disease and TAVR

Conference:

Toronto experience with TAVR: a large single centre registry

J.E. Davies BDS, PhD, DSc, FSBE

Address J.E. Davies Professor, Bone Interface Group, Faculty of Dentistry and Institute for Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario, Canada M5S 3G9. Email: [email protected]

Davies is a Full Professor at the Faculty of Dentistry, University of Toronto, and is cross-appointed to the Institute of Biomaterials and Biomedical Engineering, and also the Faculties of both Applied Science and Engineering, and Medicine. He is the founding President of Tissue Regeneration Therapeutics Inc. a mesenchymal stem cell company based in Toronto. Davies trained as an anatomist, dental surgeon and oral surgeon in the UK. His PhD, in solid-state and surface physics, was focused on understanding electron and ion transition events in calcium phosphates. In 1998 Davies was awarded a DSc by the University of London, England, for his sustained contributions over 20 years to the field of Biomaterials. Davies was recruited by the University of Toronto in 1988. He was the recipient of the prestigious Clemson Award for Basic Research in 2000. He has edited 2 books, The BoneBiomaterial Interface and Bone Engineering – both of which have been heralded as key reference works. He has also published over 200 hundred scientific papers and book chapters. He is best known internationally for his work in understanding bone healing around implanted devices. His most recent research has focused on the harvesting, characterization, and utility of mesenchymal stem cells; and his discovery of the richest source of such cells in human tissue, from the perivascular region of the umbilical cord. Area of interest:

Biomaterials and biomedical engineering

Conference:

IBBME at the University of Toronto and the development of MSC therapeutics

Howard Hu, M.D., M.P.H., Sc.D. Dean & Professor, Dalla Lana School of Public Health University of Toronto Dr. Hu came to the University of Toronto as the Dalla Lana School of Public Health's second permanent Director and Professor in July of 2012. He is a physician-scientist, trained as an internist, occupational and environmental medicine specialist, and epidemiologist. Previously, Dr. Hu had been Professor of Occupational and Environmental Medicine and Founding Director and PI of the NIEHS/EPA Center for Children’s Environmental Health and Disease Research at the Harvard School of Public Health and the Channing Laboratory of the Brigham & Women's Hospital in Boston, Massachusetts from 1988 to 2006. Most recently, Dr. Hu was the NSF International Chair of the Department of Environmental Health Sciences, Professor of Environmental Health, Epidemiology & Internal Medicine at the University of Michigan Schools of Public Health & Medicine from 2006 to 2012. During his tenure, the Department recruited 14 new faculty, re-built programs, and launched several innovative initiatives in areas such as environmental epigenetics and nutrient-toxicant interactions. Dr Hu was also the Founding Director and PI of the NIEHS P30 Core Environmental Health Sciences Center at the University of Michigan and served as the Chair of the School-wide steering committee on global health.

Mailing address: Primary Office Dalla Lana School of Public Health 155 College Street, 6th Floor Toronto, Ontario Canada M5T 3M7 [email protected]

Area of interest: • Impacts of exposure to potentially toxicants that are of critical importance to public health and medicine • Gene-environment interactions; epigenetic dysregulation Conference: Air Pollution and Cardiovascular Disease: Health Impacts, Mechanisms, and Research Opportunities

Greg Evans, M.A.Sc., Ph.D., P.Eng. Director of the Southern Ontario Centre for Atmospheric Aerosol Research (SOCAAR) University of Toronto, Faculty of Applied Science & Engineering

[email protected]

Dr. Evans is a Professor of Chemical Engineering and Applied Science and a former ViceDean Undergraduate and Chair First Year in the Faculty of Applied Science and Engineering at the University of Toronto. He is also the founding Director of the Southern Ontario Centre for Atmospheric Aerosol Research (SOCAAR), an interdisciplinary research centre studying the environmental and health impacts of air pollutants. Finally, he is the Co-Leader of Engineering Leaders of Tomorrow, a leadership development program for engineering students based in the Faculty of Applied Science and Engineering, Leaders of Tomorrow. Area of interest:

Connections between emissions of pollutants, the quality and composition of urban air, and the impact of aerosols on human health and the environment.

Conference: Every breath you take: air pollution exposure and its impacts on health

Paul Dorian, MD, MSc, FRCPC The Department Director, Division of Cardiology, University of Toronto and Staff Cardiac Electrophysiologist at St. Michael's Hospital. He is Professor of Medicine in the Division of Cardiology and in the Division of Clinical Pharmacology at the University of Toronto, and a Staff Scientist at the Li Ka Shing Knowledge Institute. Dr. Dorian received his medical degree from McGill University in Montreal in 1976. He continued training in Internal Medicine and Cardiology at the University of Toronto, and received certification by the Royal College of Physicians and Surgeons of Canada in Internal Medicine in 1983 and certification in Cardiology in 1984. He completed training in Clinical Pharmacology at the University of Toronto in 1982, and received an MSc in Pharmacology from the University of Toronto in 1982. From 1983 to 1985, he completed a Fellowship in Cardiac Electrophysiology at Stanford University Medical Centre in California. His research interests include basic science research in advanced cardiac life support and atrial fibrillation, the clinical pharmacology of antiarrhythmic drugs, and clinical research on implanted devices, antiarrhythmic drugs, and quality of life in patients with arrhythmias. He is a Co-PI on the NIH funded Resuscitation Outcomes Consortium, and serves on the steering committee of multiple multicenter clinical trials in arrhythmia care.

Mailing address: St. Michael´s Hospital Division of Cardiology Rm 6-050 Queen Wing 30 Bond Street Toronto, Ontario Canada M5B 1W8 [email protected]

He has published over 300 peer reviewed papers and is Associate Editor of the textbook Electrophysiological Disorders of the Heart.

Area of interest:

Electrophysiology

Conference:

The update on atrial fibrillation: from rhythm to anticoagulation (videoconference)

Adam Herman, Bio.

Adam Herman, BSc, graduated from the University of British Columbia in 2010. He then worked at the BC Children’s Hospital as a Medical Laboratory Assistant for two years before moving to Toronto in the summer of 2012. Since moving to Toronto, Adam has worked as a Clinical Research Data and Regulatory Coordinator for Dr. Michael Farkouh in the division of Cardiology. Adam is enrolled in a master’s program in the fall as he continues to pursue his goal of working as a clinician/scientist.