University of British Columbia Curriculum Vitae for Faculty Members Date: Mar 4, 2013 Verification Initial: 1.
SURNAME:
Byrne
FIRST NAME: Michael MIDDLE NAME(S): Francis
2. DEPARTMENT/SCHOOL:
Medicine
3. FACULTY:
Medicine
JOINT APPOINTMENTS:
4. PRESENT RANK:
Clinical Professor
SINCE: Dec 1, 2003
5. POST-SECONDARY EDUCATION (a) University or Institution Cambridge University
Degree
Subject Area Medicine
Dates 2001/07 - 2001/12
MD
Cambridge University
MA (Hons)
Medical Studies/Psychology
1993/07 - 1993/12
Liverpool University
MB ChB
Clinical Medicine
1989/07 - 1992/06
Cambridge University
BA (Hons)
Medical Studies/Psychology
1986/07 - 1989/06
(b) Title of Dissertation and Name of Supervisor Title of Dissertation The interaction between Helicobacter pylori and cyclooxygenase in gastric and vascular models. (Accepted for the degree of Doctor of Medicine by the University of Cambridge, 2001).
Supervisor Supervisor: Professor Desmond Fitzgerald and Dr. Frank Murray, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland
(c) Continuing Education or Training (d) Continuing Medical Education Printed: 4/Mar/2013
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(e) Professional Qualifications 1
Medical License, College of Physicians and Surgeons of British Columbia, 2003
2
Fellow of the Royal College of Physicians of Canada (FRCPC), 2003
3
Endoscopic Ultrasound Biopsy Course, University of Pittsburgh Medical Centre, 2002
4
Certificate of Satisfactory Completion of Specialist Training (CSCST) in Gastroenterology and General Internal Medicine - 2002, Irish Committee on Higher Medical Training Gopen’s Writing Workshop Accreditation, 2002
5 6 7
European Diploma of Gastroenterology, European Board of Gastroenterology accreditation, European Union of Medical Specialists, 2001 Medical License, North Carolina Medical Board, 2001-2003
8
European Fellow of Gastroenterology, European Union of Medical Specialists, 2001
9
Advanced Cardiac Life Support (ACLS), 2001
10
Royal College of Radiology Certificate, 1996
11
Fellow of the Royal College of Radiologists (FRCR Part 1), 1996
12
United States Medical Licensing Examination (USMLE), 1995
13
MRCP (UK) Part 2 Royal College of Physicians of Edinburgh, 1995
14
MRCP (UK) Part 1 Royal College of Physicians of Edinburgh, 1994
15
FMGEMS Part 1, 1991
6. EMPLOYMENT RECORD (a) Prior University, Company or Organization Rank or Title University of British Columbia Clinical Associate Professor
Dates 2003/07/01 - 2010/06/30
Duke University Medical Centre & VA Medical Centre, North Carolina, USA
Advanced Endoscopy Fellow
2001/07/01 - 2002/06/30
Beaumont Hospital, Dublin, Ireland
Locum Consultant in Gastroenterology/GIM
2001/07/01 - 2001/10/31
Beaumont Hospital/Royal College of Surgeons, Dublin, Ireland
Specialist Registrar in Gastroenterology/GIM Honorary Lecturer in Therapeutics
2000/07/01 - 2001/06/30
Royal College of Surgeons in Ireland/ Beaumont Hospital, Dublin, Ireland
Lecturer in Therapeutics & Research Fellow in Gastroenterology
1998/07/01 - 2000/06/30
Beaumont Hospital/Royal College of Surgeons, Dublin, Ireland
Registrar in Gastroenterology/GIM and Lecturer in Medicine
1997/07/01 - 1998/06/30
St. Vincent’s Hospital, Dublin, Ireland
Registrar in Gastroenterology/GIM
1997/03/01 - 1997/06/30
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Edinburgh Royal Infirmary, Edinburgh, UK
Specialist Registrar in Radiology 1995/10/01 - 1997/02/28
Royal North Shore Hospital, Sydney, Australia
Registrar in Medicine/Accident & 1995/05/01 - 1995/08/31 Emergency
University Hospital, Queen’s Medical Centre, Nottingham, UK
Senior House Office in Medicine 1993/08/01 - 1995/04/30
Royal Liverpool University Hospital, UK
House Officer in Medicine & Surgery
1992/08/01 - 1993/07/31
(b) Present University, Company or Organization Rank or Title University of British Columbia Clinical Professor
Dates 2010/07/01 - present
Vancouver General Hospital
Co-Director, Luminal Clinical Trials Group
2009/07/01 - present
University of British Columbia
Co-Director, UBC Interventional Endoscopy Fellowship Program
2007/07/01 - present
Vancouver Hospital & Health Sciences Centre (VGH & UBC-site)
Attending Gastroenterologist (Active Staff)
2003/07/01 - present
Duke University Medical Centre & VA Medical Centre, North Carolina, USA
Attending Gastroenterologist
2002/07/01 - 2003/06/30
(c) At UBC (since first employment) (d) Date of granting of tenure at UBC: 7. LEAVES OF ABSENCE
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8. TEACHING (a) Areas of special interest and accomplishments Accomplishments 1 I have wide experience in undergraduate teaching both in a tutorial setting and in ward-based patient-orientated setting, including formal teaching and examination of medical students. I also have experience in teaching at a postgraduate level, both medical and allied professions. 2 My role as lecturer in therapeutics in Dublin, Ireland, also included a wide range of administrative and organisational duties. 3 I continued my teaching commitments as a member of faculty in Duke University Medical Center, teaching undergraduate students and post-graduate medical residents. I had a daily commitment to the clinical education of the GI fellows and advanced endoscopy fellows. 4 I completed a 4 month, 16 session formal teaching workshop at Duke University Medical Center for faculty development in clinical teaching. This course was based on the “Train the trainer” model developed at Stanford University. 5 In my role as Clinical Professor at the University of British Columbia, I have a regular commitment to the formal teaching programs of undergraduate medical students, and junior doctors. I also continue to regularly teach students and doctors at Vancouver General Hospital. 6 See section 8f for teaching history. Special Interest 1 Special interest in teaching both postgraduate and undergraduates in the fields of pancreaticobiliary disease, interventional endoscopy, general gastroenterology, clinical and basic science research. Teaching 1 In addition to formal teaching of undergraduate and postgraduate students at UBC, I continue to remain involved in teaching on a very regular basis. As a co-director of the Interventional Endoscopy Fellowship at UBC, I am the main supervisor at VGH for the visiting ERCP fellow. This involves not only teaching in the technique of ERCP/EUS/other interventional endoscopy but also mentoring in pancreatic or biliary disease and encouraging the fellow to keep up to date with literature in the field. I also regularly engage with the interventional endoscopy fellow in relation to his or her research commitments. In addition I make myself freely available to the general GI fellows on our program and encourage them to take part in my endoscopy sessions for teaching. When I am on call at VGH, I make it a priority to dedicate fixed times throughout the week to bedside teaching or teaching on topics of interest to the fellows, residents and medical students on the service at that time. For the interventional endoscopy fellow alone, in terms of mentoring and teaching the fellow in this position, I spend in the region of 12 hours a week with this fellow with clinical cases, research, follow-up and career mentoring. (b) Courses Taught at UBC Year
Session
Course Number
Description
Scheduled Hours
2006/08/11
3rd year Oral Exams
2.00
2006/08
PBS teaching
1.00
2006/06/16
3rd year Oral Exams
2.00
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Byrne , Michael
Class Size
Hours Taught Lectures Tutorials
Labs
4
Other
2006/05/12
2.00
2nd Year Bedside Teaching Sessions 3rd year Oral Exams
2006/04/21
2006 present
2.00
Ongoing teaching commitment as detailed elsewhere in attached documents
2005/09/30 2006/09/30
GI Clinical Skills
2.00
2005/09/23 2006/09/23
GI Clinical Skills
2.00
2005/09
GI Clinical Skills
2.00
2005/06/17
3rd year Oral Exams
2.00
2005/04/22
3rd year Oral Exams
2.00
2004/11
GI Clinical Skills
4.00
2004/10/29
3rd Year Oral Exams
2.00
2004/08/13
3rd Year Oral Exams
2.00
1998/07/01 2001/06/30
RCSI Therapeutics 1st, 2nd and 3rd year final med RCSI
(c) Students supervised Student Name
Progra m Type
Program Details
Year Start
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Supervisory Role
Current Position/Awards
Finish
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Dr Nawal Al Nahdi
Interventional endoscopy fellowship
2012
2013
Primary Supervisor
Dr Edward Kim
Interventional endoscopy fellowship
2012
2013
Primary Supervisor
Dr Calvin Chan
Interventional endoscopy fellowship
2011
2012
Primary Supervisor
Dr Fergal Donnellan
Interventional endoscopy fellowship
2010
2011
Primary Supervisor
Dr Marcus Chin
ERCP Fellowship
2009
2010
Primary Supervisor
Dr. Holly Weisinger
GI Resident Research
2009
2009
Primary Supervisor
Dr. Alan Coss
ERCP Fellowship
2008
2009
Primary Supervisor
Dr. Mark McLoughlin
ERCP Fellowship
2007
2008
Primary Supervisor
Dr. Iman Zandieh
GI Resident Research
2007
2007
Primary Supervisor
Dr. Jaber Al Ali
ERCP Fellowship
2006
2007
Primary Supervisor
(d) Continuing Education Activities CME 1
3
CME on the Run Conference - GERD and Dyspepsia, Vancouver General Hospital, December 7, 2012. Multi-Specialty Nurses Program. “The 5W’s of Biological Therapy for Crohn’s Disease: Who, What, When, Where, and What to Expect”. November 30, 2010. Downtown GP Group - GI Potpourri. April 2009.
4
Update on GERD and Fatty Liver - Vancouver GP Group, Vancouver, Aug 2007.
5
Seymour Medical Group - GI Pot Pourri. Vancouver, March 2007.
6
IBD update - Nurse Education Day. VGH, March 2007.
2
7
Vancouver GP Group - GI Risk Profiling in the Arthritic Patient. Vancouver, Jan 2007.
8 9
Vancouver GP Group - The future of prokinetics in North America: What does the evidence say? Vancouver, June 2006. Richmond GP Group - GI risk profiling in the arthritic patient. Richmond, Feb 2006.
10
CME - Fatty Liver Disease, Comox, Jan 2006.
Other 11 GI Academic quarter day lecture: Approach and Management of Biliary Strictures, Diamond Health Care Centre, January 22, 2013. Printed: 4/Mar/2013
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12 13
“Update on Ulcerative Colitis: What our patients aren’t telling us and what we should be telling them”. Moderator. Presented to UBC GI fellows. August, 2011. Presented to fellows GI Academic quarter day lecture: Biliary Dysmotility, March, 2011. Presented to fellows.
14
Update on Gastrointestinal Bleeding. UBC General Surgery Update, December 2009.
15
Medical Residents Program - Autoimmune Liver Disease. VGH/UBC, May 2008.
16
Vancouver GP Group - Prokinetics and Probiotics as Relating to IBS and Dyspepsia, May 2008.
17
Highlights from the 15th UEGW meeting, Vancouver Gut Club, Jan 2008.
18
UBC Surgical Academic Half Day, VGH, GI Bleeding, Oct 2007.
19
Vancouver GP Group - The Appropriate Use of Prokinetics and Probiotics in Family Practice, May 2007. GERD - UBC Telerounds for CPDKT, November 2006.
20 21 22 23
Hot Topics in Gastroenterology - The Pancreas in Primary Care. University of British Columbia, Oct 2006. CSGNA Vancouver Chapter Meeting - CME on Enteral Stents, VGH 2006.
24
Medicine in the 21st Century, Advances in Internal Medicine - screening colonoscopy for colorectal cancer, June 8 - 10, 2006. DDW Review - Interventional Endoscopy, June 2006.
25
Exchange program, Gain Medical, Vancouver, May 2006.
26
GI Fellows/Residents Academic Quarter Day - Acute Pancreatitis. January 10, 2006.
27
GI Fellows/Residents Academic Quarter Day - Peptic ulcer disease and H. pylori. September 20, 2005. Vancouver Gut Club - How to minimise post-ERCP Pancreatitis. February 2005.
28 29 30 31
Academic Quarter Day - Management of acute pancreatitis. Vancouver General Hospital, University of British Columbia, February 2005. Vancouver Gut Club - Proper use of pancreatic enzymes. November 2004.
32
Hot Topics in Gastroenterology Teaching Day - GERD—what’s really up? University of British Columbia, October 2004. Academic Quarter Day - Pancreatic Cancer. UBC Division of Gastroenterology, September 2004.
33
British Columbia DDW Review Course - Advances in Therapeutic Endoscopy. June 2004.
34 35
Acid Related Issues. Can We Improve Outcomes? Surrey Memorial Hospital, Vancouver, June 2004. Clinical Management of GI Disorders, West 10th GP Group, May 2004.
36
Western Regional Journal Club - Clinical use of infliximab. Vancouver, February 2004.
37
Novartis Course - Endoscopy of the upper gastrointestinal tract. Duke University Medical Center, April 2003. Academic Quarter Day - A Potpourri of ERCP. Vancouver General Hospital, University of British Columbia. February 2003. Vancouver Gut Club - Helicobacter Pylori and Heartache. Fact or Fiction? City Wide Rounds, Vancouver. February 2003. Audit Nurse Training Meeting - Management of Dyspepsia in General Practice. Galway, Ireland, October 2000. Common Medical Emergencies Series - Acute Live Failure. Beaumont Hospital, Dublin, May 1998. Critical Care Symposium - Management of Liver Disease in the Intensive Care Unit. Beaumont Hospital, Dublin, January 1998. Clinical Nutrition Symposium, National Study Day - Technique for PEG insertion. Dublin, June 1997.
38 39 40 41 42 43
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Rounds 44 UBC Surgical City Wide Rounds, VGH. “Advances in Interventional Endoscopy. Where are we heading?” November, 2010. 45 VGH Department of Medicine Grand Rounds. “Advances in interventional endoscopy: where are we heading?” September 9, 2010. 46 Family Practice Grand Rounds - Advances in E.R.C.P. VGH, May 2008. 47
Professor’s Rounds, University of British Columbia, September 8, 2006.
48
Grand Rounds - Fatty Liver Disease. Abbotsford Hospital, 2006.
49
Grand Rounds - Fatty Liver Disease. MSA Hospital, Abbotsford, BC, October 2005.
50
Professor’s Rounds, University of British Columbia, August 5, 2004.
51
Professor’s Rounds - Management of intestinal ischemia. University of British Columbia, May 2004. Grand Rounds - Intestinal polyp diseases. Vancouver General Hospital/UBC, March 2004.
52 53 54
Surgical Grand Rounds - Common Bile Duct Stones. Vancouver General Hospital, University of British Columbia, February 2004. Grand Rounds - Cyclooxygenase - New Insights. Duke University Medical Center, Feb 2002.
(e) Visiting Lecturer (indicate university/organization and dates) (f) Other 1
Clinical Professor
2
Supervisor (for medical students) and Co-author, Gastroenterology section Clinical Associate Professor Examiner
3 4
5 6
Medical Tutor
7
Lecturer
8
9
10 11
Lecturer in Medicine and Tutor Registrar
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University of British Columbia, 2010-present University of British Columbia, 2009 University of British Columbia, 2003-2010 University of British Columbia Medical School, 2003-present Royal College of Physicians in Ireland, June 2001 Duke University Medical Center, 2001-2003 Royal College of Surgeons in Ireland (RCSI), 19982001 RCSI/Beaumont Hospital, 1998-2000 Royal College of Surgeons in Ireland Medical School, 1998-2000 Royal College of Physicians in Ireland, November 1997 RCSI/Beaumont Hospital, 1997-1998
Byrne , Michael
Essential Review for the MCCQE text
Organizing Registrar for Part II Membership Examination
Therapeutics 1st, 2nd, 3rd and final med Responsible for organization of therapeutics course for 3rd and final medical year 1st, 2nd, 3rd and final year medical examinations (pharmacology) Organising Registrar for Part II Membership Examination
8
12
Tutor
13
Tutor
Beaumont Hospital, 19972001 University Hospital, Nottingham, 1996-1997
MRCPI (parts I and II) teaching MRCP course
9. SCHOLARLY AND PROFESSIONAL ACTIVITIES (a) Areas of special interest and accomplishments Basic Research 1 In 2001, my research thesis was accepted for the degree of Doctor of Medicine by the University of Cambridge: “The interaction between Helicobacter pylori and cyclooxygenase in gastric and vascular models”.
2
3 4
5
All of this work was performed in the Department of Clinical Pharmacology in the Royal College of Surgeons in Ireland. I now have considerable experience in the study of cyclooxygenase in both gastric biopsies and cell lines. I am very familiar with the techniques used in cell culture, mass spectrometry, immunohistochemistry, ELISA, PCR, Western blotting and apoptosis/cell proliferation assessment. I have also spent a significant amount of time working in the platelet biology field (in relation to H. pylori induced platelet aggregation) and have experience in measurement of platelet aggregation, flow cytometry, and confocal microscopy. For my work with cyclooxygenase and with platelets, I have performed many transient transfection studies with COX promoter constructs and integrin constructs. Having spent some time with Dr John Atherton in the department of gastroenterology in Queen’s Medical Centre, Nottingham, I am competent in the techniques for culture of Helicobacter pylori. The laboratory in which I worked is well equipped consisting of 5,000 sq ft of modern labs, including cell culture, immunohistochemistry, immunofluorescence, mass spectrometry (quadropole electrospray), flow cytometry, an automated DNA sequencing/genetic analysis unit and facilities for molecular biology. The personnel in the department include Post-Doctoral researchers, research assistants, technicians and post-graduate students. I gained considerable experience in writing research grant proposals and was successful in receiving three grants (£130,000 total for salary and consumables) to support this work. I continued to act as a co-supervisor (on an advisory basis when I moved to the USA) to a PhD student (Paul Corcoran) in the Dept of Clinical Pharmacology, RCSI. Paul was awarded his PhD in 2004. I continue to collaborate with my former colleagues in the Dept of Clinical Pharmacology, RCSI, and have recently submitted a follow-up study to our earlier work on H. pylori and platelets.
Clinical Research - Vancouver General Hospital 1 I am currently involved in several clinical studies in Vancouver (details in separate document of multiple clinical trials in which I am/have been PI or co-investigator at VGH/UBC since 2008). I was the PI in retrospective studies looking at NASH in diabetic and dyslipidaemic patients and collaborated with the University Division of Endocrinology in this regard. I also investigated early stent failure in malignant distal biliary obstruction; the fate of patients who undergo preoperative ERCP for bile duct stones; investigation algorithms for ERCP and intraoperative cholangiography; our clinical experience with the use of glue for gastric varices; the outcome of patients who undergo extracorporeal shockwave lithotripsy for bile duct stones; and the outcome of post liver transplant patients who need ERCP, as well as many other research projects. Previously, there were a very large number of research opportunities at Duke University Medical Center, particularly on the biliary service, and I was involved in many research projects, several of which I initiated. Many studies have been presented at national and international meetings, and published in peer-reviewed journals. Other Scholarly and Professional Activities 1 My aim, with the support of the Division Head, Dr. Eric Yoshida, is to improve the endoscopy Printed: 4/Mar/2013
Byrne , Michael
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2
3 4
5
services provided at Vancouver General Hospital and UBC Hospital. I was elected director of endoscopy in early 2012, with responsibility for all endoscopists, medical and surgical, within the unit. This role is very busy and is detailed elsewhere. I previously served a pivotal role on the Endoscopy Executive Committee and through this body I have fostered relations with the hospital management and the hospital foundation. We were successful in bringing endoscopic ultrasound to the hospital, a much needed service in cancer diagnosis and other areas. I have had exploratory discussions with the Department of Nursing to try and bring a nurse practitioner to the GI service. I was the key physician involved in the region wide proposal for a new endoscopy inventory for over 10 hospitals. I decided a few years ago that there was a need to establish an advanced endoscopy training fellowship at UBC and after discussing this with my colleague Dr. Rob Enns at St. Paul’s Hospital, this new Interventional Endoscopy Training Fellowship was established in 2007 and has been incredibly popular ever since. This program undoubtedly raises the profile of the Division. I was the instigator for the recent establishment (2008)of the Luminal Clinical Trials group at VGH/UBC and am one of the two co-directors, and will be involved in several clinical trials in this role. Details are elsewhere in this document. I was previously appointed to the Department of Medicine’s Research Strategic Committee. I have completed, as lead author, the National Position Statement on behalf of the Canadian Association of Gastroenterology (CAG) for the use of propofol in endoscopy for adults in Canada. I am a collaborator for the CIHR study on colorectal cancer screening looking at genomic, imaging and modeling approaches.
Research Interest 1 I have research interest both in basic science and clinical medicine and have published a large number of peer reviewed papers in both of these areas. These are detailed in the attached bibliography. (b)+(c) Research or equivalent grants/contracts (indicate under COMP whether grants were obtained competitively (C) or non-competitively (NC)) Grants Granting Agency Funding for Interventional Endoscopy Fellowship Programme
NC
$65,000
2012
Principal Investigator M Byrne R Enns
Funding for Interventional Endoscopy Fellowship Programme
NC
$65,000
2011
M Byrne R Enns
Funding for Interventional Endoscopy Fellowship Programme
NC
$65,000
2010
M Byrne R Enns
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Subject
COMP
Funding Details
Amount
Byrne , Michael
Year
CoInvestigator(s)
10
Funding for Interventional Endoscopy Fellowship Programme
NC
$65,000
2009
M Byrne R Enns
Funding for Interventional Endoscopy Fellowship Programme
NC
$65,000
2008
M Byrne R Enns
2007 2008
I Tai
Collaborator for CIHR proposal Colorectal Cancer Screening Funding for Interventional Endoscopy Fellowship Programme
Schering Canada Inc.
Human Genome Sciences
A study to assess treatment with pegylated interferon and ribavirin in naive patients with genotype 1 chronic hepatitis c and slow virologic response (P03685) A phase 2b randomized multi-center active-controlled open label study to evaluate the efficacy and safety of Albuferon in combination w/ ribavirin in interferon alpha naive subjects w/ chronic hepatitis c genotype 1. (ALFR-HC-04)
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NC
M Byrne A Weiss P Kwan N Chatur
NC
$115,000
2007
M Byrne R Enns
NC
$45,500
2005 2006
E M Yoshida
U Steinbrecher WCP Kwan S Erb M Byrne J Gray
NC
$355,218
2005 2006
E M Yoshida
U Steinbrecher S Erb W C P Kwan J Gray M Byrne
Byrne , Michael
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Human Genome Sciences Ltd.
Migenix
Duke University Junior Faculty Research Award
NC A doubleinjection, doseranging study to evaluate the safety, tolerability, pharmacodynami cs, and pharmacokinetics of albuferon in interferon alpha naive subjects with chronic hepatitis C genotype 1 (ALFR-HC-03CA) NC A phase II randomized, dose ranging open label, multicentre study to evaluate the safety and efficacy of Celgovsivir for 12 weeks in subjects with chronic hepatitis C infection (HCV-01-004) Endoscopic C Ultrasound research
$51,000
2004
E M Yoshida
U Steinbrecher S Erb M Byrne
$32,000
2004
E M Yoshida
U Steinbrecher S Erb M Byrne
$2,500
2003
M Byrne
University of Pittsburgh EUS research Endoscopic Ultrasound Award
NC
$2,000
2002
M Byrne
Duke University Junior Faculty Research Award
ERCP research
C
$1,500
2002
M Byrne
Charitable Infirmary Charitable Trust, Dublin
Cyclooxygenase Research
C
1999 2001
M Byrne
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£50,000 GBP
Byrne , Michael
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Contracts Salary Support Award Granting Agency
Subject
COMP
Boston Scientific ERCP/EUS training Interventional Fellowship, Duke University Medical Center, North Carolina, USA
C
Royal College of Surgeons in Ireland Research Grant
H. pylori Research
NC
Royal College of Surgeons in Ireland
Clinical C Pharmacology Research Fellowship (Thesis Research)
Funding Details
Amount
$45,000
Year
2001 2002
£18,000 GBP
1998 2000
£60,000 GBP
1998 2000
Principal Investigat or M Byrne
CoInvestigator(s)
M Byrne
(d) Invited Presentations 1
2 3 4 5 6 7
Wiesinger H, Coss A, Haque M, Scudamore CH, Steinbrecher UP, Chung SW, Buczkowski AK, Yoshida EM, Byrne MF. Endoscopic retrograde cholangiopancreatography in the management of biliary complications following liver transplantation: a review of local practice and outcomes. Presented at GRIT fellows meeting, February 2010. 15th Annual DDW Review Meeting,Vancouver, BC (UBC CPD approved meeting). Therapeutic endoscopy/EUS. 2010. Invited Faculty - Faculty for GI forum, St. Paul’s Hospital, October 2009. 4th Annual Winter Clinical Practice Update - Dermatological Manifestations of GI Disease. Val D’Isere, France, Mar 2008. “Expanding our Scope” - Invited faculty for the CSGNA’s National Conference, 2008. Hepatitis and Liver Disease Conference. Therapeutic Endoscopy and Biliary Tract Disease (Dr. Mark McLoughlin, UBC Therapeutic Endoscopy Fellow), October 2007. Presentation on UBC Endoscopy. Medical Affairs Committee, VGH, Oct 2007.
8
BC Society of Allergy and Immunology - Eosinophilic Esophagitis. Whistler, March 2007.
9
CME on Enteral Stents - CSGNA Vancouver Chapter Meeting. VGH 2006.
10
Inside Tract Conference - How Can I Support my Bowel? Supplements Like Probiotics and Fibre. Vancouver, June 2005. Use of Selective Cycoloxygenase-2 Inhibitors. Dublin Orthopaedic Society, Adelaide and Meath Hospital, April 2001. Royal College of Physicians - Pathogenesis of Gallstones. Dublin, March 2000.
11 12 13 14
Masterclass in Gastroenterology Research - The Interaction Between Helicobacter Pylori and Cyclooxygenase in Gastric and Vascular Models. Beerse, Belgium, Feb 2000. Open label, multi-centre, safety assessment of a marketed medicine (SAMM): comparison of aceclofenac with diclofenac SR. London, England, September 1999.
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The Gut in Critical Illness seminar - Management of Gastrointestinal Bleeding. National Intensive Care Society of Ireland. Dublin, November 1998.: Clinical Nutrition Symposium, National Study Day - Technique for PEG insertion. Dublin, June 1997.
(e) Other Presentations 1 2
3 4 5 6
7 8 9
10
11
12 13 14
15 16 17 18 19
20
Liver biochemistry abnormalities in a quaternary care lipid clinic database. Oral presentation (JA Shah) at fellows course, CDDW 2007. Extensive Investigation of Patients with Mild Elevations of Serum Amylase +/- Lipase Is “Low Yield” and Not Cost-Effective. Digestive Diseases Week, American Society for Gastrointestinal Endoscopy, San Francisco, May 2002. COX-2 expression and dysplasia in human colorectal adenomatous polyps. British Society of Gastroenterology, Birmingham, 2002 (middle author). Cyclooxygenase-2 expression and dysplasia in human colorectal adenomatous polyps. Oral presentation. Irish Society of Gastroenterology, Dublin, Nov 2001 (middle author). A role for von Willebrand factor in Helicobacter pylori-induced platelet aggregation. Irish Society of Gastroenterology, Dublin, Nov 2001 (last author). Generation of the anti inflammatory prostaglandin PGJ2 in vitro and ex vivo and a possible role as an anti-inflammatory agent in IBD. Irish Society of Gastroenterology, Dublin, Nov 2001 (2nd author). Role of transcription factor NF-?B in cyclooxygenase-2 promoter induction by H pylori in endothelial cells. Irish Society of Gastroenterology, Dublin, Nov 2001 (last author). The interactions between Helicobacter pylori and the vasculature-implications for gastric pathogenesis and cardiovascular risk. Irish Society of Gastroenterology, Cork, June 2001. The Interactions Between Helicobacter Pylori and the Vasculature Implications for Gastric Pathogenesis and Cardiovascular Risk. Research Day, Royal College of Surgeons in Ireland, April 2001 (last author). The interactions between Helicobacter pylori and the vasculature-implications for gastric pathogenesis and cardiovascular risk. Royal College of Surgeons in Ireland, Research Day, April 2001. The interactions between Helicobacter pylori and the vasculature-implications for gastric pathogenesis and cardiovascular risk. Royal Academy of Medicine, Royal College of Physicians of Ireland, Apr 2001. Fas ligand expression, clinicopathological features and outcome in human colorectal cancer. National Scientific Medical Meeting, Royal College of Physicians of Ireland, April 2001. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. United European Gastroenterology Week, Brussels, November 2000. Regulation of the promoters of both cylcooxygenase-1 and -2 by Helicobacter pylori in gastrointestinal cancer cells. United European Gastroenterology Week, Brussels, November 2000. Mechanisms of platelet aggregation induced by Helicobacter pylori. United European Gastroenterology Week, Brussels, November 2000. Differential cyclooxygenase-2 expression and regulation in colorectal cancer cells. United European Gastroenterology Week, Brussels, November 2000. A role for platelet glycoproteins in Helicobacter pylori induced platelet aggregation. Irish Association of Pharmacologists, Dublin, November 2000. The promoter of the ‘constitutive’ cyclooxgenase-1 gene is driven by Helicobacter pylori. Irish Society of Gastroenterology, June 2000. Evidence of transcriptional regulation of the cyclooxygenase-2 promoter by Helicobacter pylori in gastrointestinal cancer cells. Digestive Diseases Week, American Gastroenterological Association, San Diego, May 2000. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells.
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Royal College of Surgeons in Ireland, Research Day, April 2000. 21 22 23
Strain specific Helicobacter pylori induced platelet aggregation: implications for gastric pathogenesis. Royal Academy of Medicine, Royal College of Physicians of Ireland, Apr 2000. Helicobacter pylori induces platelet aggregation in vitro: mechanism of action and strain specificity. British Society of Gastroenterology, Birmingham, March 2000. Regulation of Cyclooxygenase-2 promoter activity by Helicobacter pylori in gastrointestinal cancer cells. Irish Society of Gastroenterology, Dublin, November 1999.
(f) Other 1
Attended numerous conferences/courses/seminars as a “participant” from 2002-present.
Clinical Trials 1 Principal Investigator on the Schering OPTIMIST trial. 2
Sub-Investigator on the following: • Abbott M11-271 (CALM) Algorithm-controlled management of CD with prednisone, adalimumab, ADA and AZA combo. • Abbott P10-789 (VISION) Validation of the SPACE questionnaire • Centocor REMICADECRD3001(PREVENT)--Remicade post-resection for prevention of CD recurrence • Centocor CNTO12753002--ustekinumab for CD for patients who have failed/intolerant to conventional therapy • and Centocor CNTO12753003-Maintenance study) • Pfizer B2421003--Anrukinzumab for UC patients • Pfizer A7281006 (OPERA)--anti-Madcam for CD patients who have failed/intolerant to conventional therapy • Pfizer A7281007 Open-Label study for A7281006 patients • Amgen 20110166--AMG 181 for patients with UC who have failed/intolerant to conventional therapy •Amgen 20110232--AMG 181 for patients with CD who have failed/intolerant to conventional therapy • Cook Medical HALT (Hemospray)
(g) Conference Participation (Organizer, Keynote Speaker, etc.) 1
11th Annual BC GI Forum, Issues in sedation for endoscopy. October 2012.
2
11th Annual BC GI Forum, moderator/faculty, October 2012.
3
Moderator/Faculty, 10th Annual BC GI forum, October 2011.
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Canadian Endoscopy Forum, San Jose, April 2009.
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Interdisciplinary Forum in GI Medicine, Chair of session, October 2006.
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Round Table discussion on Pancreatic Disease and ERCP, Vancouver, June 2007 (chairperson). Meeting organised by Dr. M. F. Byrne. Gut Club - Pancreatitis (Dr. John Baillie as speaker), Vancouver, June 2007 (chairperson). Meeting organised by Dr. M. F. Byrne. Gut Club - Interventional Endoscopy (Dr. Michael Kochlan as speaker), Vancouver, June 2009. Meeting organised by Dr. M. F. Byrne.
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10.1. SERVICE TO THE UNIVERSITY (a) Memberships on committees, including offices held and dates Duke University Medical Centre - North Carolina, USA 1 Duke VA Medical Centre Grading Committee, North Carolina, 2002-2003 2
GI Faculty Committee, 2001-2003
(b) Other service, including dates University of British Columbia - Vancouver, BC 1 Co-director of UBC Interventional Endoscopy Fellowship (new fellowship established by Dr. M. F. Byrne in 2006) 2 Examiner at University of British Columbia Medical School, 2003-present. 3
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PhD Supervisor: Main supervisor to Paul Corcoran, PhD student (PhD awarded 2004), Dept of Clinical Pharmacology, RCSI - “Interactions between Helicobacter pylori and the vasculature”, 2000-2003. Invited by Dean, Faculty of Graduate Studies, to serve as chair for a final doctoral oral examination.
10.2. SERVICE TO THE HOSPITAL (a) Memberships on committees, including offices held and dates Beaumont Hospital - Dublin, Ireland 1 Teaching Committee, 1997-2000 Vancouver General Hospital - Vancouver, BC 2 Director of Endoscopy, VGH/UBC, 2012-present 3
Co-Director of Clinical Trials Research Group, 2008
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Gastroenterology Representatve, Endoscopy Executive Committee, 2005-2011
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Faculty Committee, 2003-present (Working party for GI physicians and surgeons - established by Dr. M. F. Byrne and Dr. O.N. Panton in 2007)
(b) Other service, including dates Vancouver General Hospital 1 Physician Representative for the RFP for Endoscopy Equipment, 2009 2
Physician Representative for the RFP for Consumables, 2009
11. SERVICE TO THE COMMUNITY (a) Memberships on scholarly societies, including offices held and dates 1
Member of the Royal College of Physicians of Edinburgh (MRCP UK), 1995
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British Society of Gastroenterology
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American Gastroenterology Association
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Irish Society of Gastroenterology
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American Medical Association
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Royal College of Physicians of Canada
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American Society of Gastrointestinal Endoscopy
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American College of Gastroenterology
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European Board of Gastroenterology
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College of Physicians and Surgeons of British Columbia
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British Columbia Medical Association
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Canadian Medical Association
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Canadian Association of Gastroenterology
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British Columbia Society of Gastroenterology
(b) Memberships on other societies, including offices held and dates (c) Memberships on scholarly committees, including offices held and dates 1
National Endoscopy Committee, Canadian Association of Gastroenterology, 2005-2008
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Third Medical Year Review Group, Royal College of Surgeons in Ireland, 1998-2000
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Clinical Curriculum and Examinations Committee, RCSI, 1998-2000
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Irish Society of Gastroenterology Registrars Group, Treasurer, 1998-1999
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Irish Society of Gastroenterology Registrars Group, Member, 1997-2001
(d) Memberships on other committees, including offices held and dates 1 2
LMIIF Review of Gastrointestinal Services in the Lower Mainland Committee Member, 20102011 Colorectal Cancer Screening Study Committee, 2008-present
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CAG Certification (of Endoscopy Units) Program committee member, 2008-2010
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Invited to VANOC medical specialists programme for 2010 Olympics, 2007-2010
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Vancouver Annual Gastroenterology Forum Committee, 2005-present
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Claims Review Committee, Healthcare Benefit Trust, British Columbia, 2005-present
(e) Editorships (list journals and dates) 1
World Journal of Gastroenterology, 2006-present
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Internet Journal of Gastroenterology, 2005-present
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Editorial Consultant for the Physicians’ Information and Education Resource (PIER) published by the American College of Physicians
(f) Reviewer (journal, agency, etc including dates) 1
Gastroenterology & Hepatology, 2012-present
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Journal of Pain Research, 2012-present
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Imaging in Medicine, 2011-present
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Clinical Epidemiology 2011-present
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Central Commissioning Facility, 2011
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Scientific Committee Agreement to contribute in the development of the SCOPE : Selfassessment of CrOhn’s disease management in clinical PracticE initiative, 2011 The Physicians’ Services Incorporated Foundation, 2011
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Gastrointestinal Endoscopy, 2010-present
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Radiology Research and Practice, 2010-present
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Canadian Agency for Drugs and Technologies in Health, 2010
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Annals of Surgical Oncology, 2009-present
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Saudi Medical Journal, 2008-present
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Scandinavian Journal of Gastroenterology, 2008-present
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Yonsei Medical Journal, 2008-present
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World Journal of Gastrointestinal Oncology
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Pancreatology, 2007-present
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Disease Management & Health Outcomes, 2007-present
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British Journal of Cancer, 2007-present
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Clinical Medicine: Gastroenterology, 2007-present
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Journal of Gastroenterology and Hepatology, 2006-present
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Biomedcentral Gastroenterology, 2006-present
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Journal of Pediatric Gastroenterology and Nutrition, 2005-present
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Laboratory Investigation, 2005-present
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Canadian Journal of Gastroenterology, 2005-present
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Expert Review of Molecular Diagnostics, 2004-present
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World Journal of Gastroenterology, 2004-present
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Journal of the Pancreas, 2003-present
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Digestive and Liver Disease, 2003-present
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Clinical Gastroenterology and Hepatology, 2003-present
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Emergency Medicine, 2003-present
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European Journal of Gastroenterology and Hepatology, 2002-present
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Drug Safety, 2002-present
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Progress Basic and Clinical Pharmacology, 2002-present
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The American Journal of the Medical Sciences, 2002-present
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Gastroenterology, 2001-present
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American Journal of Gastroenterology, 2001-present
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Drugs, 2001-present
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Alimentary Pharmacology and Therapeutics, 2000-present
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American Journal of Managed Care, 1999
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Supervisor (for medical students) and Coauthor, Gastroenterology section, Essential Review for the MCCQE text American Journal of Gastroenterology
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Internet Journal of Gastroenterology
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Expert Review of Medical Devices
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Case Reports in Medicine
(g) External examiner (indicate universities and dates) 1
1st, 2nd and Final Year Medical Examinations (Pharmacology) 1998-2000, Royal College of Surgeons in Ireland Medical School
(h) Consultant (indicate organization and dates) (i) Other service to the community 1
Volunteer as a physician at the Canadian Open Golf Championship, July 2011
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Gastroenterologist on-call for both the Olympics and Paralympic Games: Vancouver 2010
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Clinical Trials Research Group, Vancouver. 2003-present
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12. AWARDS AND DISTINCTIONS (a) Awards for Teaching (indicate name of award, awarding organizations, date) (b) Awards for Scholarship (indicate name of award, awarding organizations, date) (c) Awards for Service (indicate name of award, awarding organizations, date) (d) Other Awards 13. OTHER RELEVANT INFORMATION (Maximum One Page) 1
NOTE: The teaching dossier template provided by the Department of Medicine which is to be used to record all of teaching activities has only been made available very recently and there are undoubtedly some formal teaching commitments over the last 5 years at UBC that are not recorded in section 8 teaching. ------Listed in Presidential Who’s Who: 2009/2010
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University of British Columbia Publications Record Date: Oct 12, 2012 Verification Initial: 1.
SURNAME:
Byrne
FIRST NAME: Michael MIDDLE NAME(S): Francis
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Byrne MF, Chan CHY, Branch MS, Jowell PS, Baillie J. Repeat Procedures Within 30 days in Patients Stented for Malignant Distal Biliary Strictures: Experience of 508 Patients at a Tertiary Referral Center. Gastroenterology Research, Volume 5, Number 2, April 2012, pages 57-62. Donnellan F, Enns R, Kim E, Lam E, Amar J, Telford J, Byrne MF. Outcome of repeat ERCP after initial failed use of a needle knife for biliary access. Dig Dis Sci. 2012 Apr; 57 (4) :106971. Chin M, Levy RD, Yoshida EM, Byrne MF. Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy. Can Respir J. 2012 Jan-Feb; 19 (1) :e1-2. Donnellan F, Byrne MF. Prevention of Post-ERCP Pancreatitis. Gastroenterol Res Pract. 2012; 2012:796751. Chan CH, Donnellan F, Chan GC, Byrne MF. A novel two-step approach for retrieval of an impacted biliary extraction basket. Case Rep Gastrointest Med. 2012; 2012:435050. Kim E, Byrne MF, Donnellan F. Endoscopic mucosal resection of esophageal squamous papillomatosis. Can J Gastroenterol 2012, vol 26. Kim EY, McLoughlin M, Lam EC, Amar J, Byrne M, Telford J, Enns R. Retrospective analysis of radiation exposure during endoscopic retrograde cholagiopancreatography: Critical determinants. Can J Gastroenterol October 2011, Volume 25 Issue 10: 555-559. Donnellan F, Moosavi S, Byrne MF. Colonic stenting in 2011. Minerva Gastroenterol Dietol. 2011 Jun;57(2):193-204. Al-Ali J, Pawlowska M, Coss A, Svarta S, Byrne M, Enns R. Can J Gastroenterol. Endoscopic management of gastric variceal bleeding with cyanoacrylate glue injection: Safety and efficacy in a Canadian population. 2010 Oct;24(10):593-6. Kim E, McLoughlin M, Lam EC, Amar J, Byrne M, Telford J, Enns R. Prospective analysis of fluoroscopy duration during ERCP: critical determinants. Gastrointest Endosc. 2010 Jul;72(1):50-7. Lynd LD, Najafzadeh M, Colley L, Byrne MF, Willan AR, Sculpher MJ, Johnson FR, Hauber AB. Using the incremental net benefit framework for quantitative benefit-risk analysis in regulatory decision-making--a case study of alosetron in irritable bowel syndrome. Value Health. 2010 Jun-Jul;13(4):411-7. Cheung J, Sawisky G, Enns R, Byrne MF, Zhu Q, Wong CK. Practices in peptic ulcer bleeding controversies among university-versus nonuniversity-affiliated gastroenterologists. Can J Gastroenterol. 2010 Apr;24(4):261-5. Coss A, Zhou C, Byrne MF, Weiss AA. Relapse of multiple myeloma presenting with biliary obstruction. Can J Gastroenterol. 2010 Apr;24(4):237-8.
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Lynd LD, Najafzadeh M, Colley L, Byrne MF, Willan AR, Sculpher MJ, Johnson FR, Hauber AB. Using an incremental net-benefit framework for quantitative benefit-risk analysis in regulatory decision making - a case study of alosetron in irritable bowel syndrome. Value Health. 2009 Sep 10. Byrne MF, McLoughlin MT, Mitchell RM, Gerke H, Kim K, Pappas TN, Branch MS, Jowell PS, Baillie J. For patients with predicted low risk for choledocholithiasis undergoing laparoscopic cholecystectomy, selective intraoperative cholangiography and postoperative endoscopic retrograde cholangiopancreatography is an effective strategy to limit unnecessary procedures. Surg Endosc. 2009 Sep;23(9):1933-7. Coss A, Byrne MF. Preoperative biliary drainage in malignant obstruction: indications, techniques, and the debate over risk. Curr Gastroenterol Rep. 2009 Apr;11(2):145-9. Coss A, Zhou C, Byrne MF, Weiss AA. Relapse of multiple myeloma presenting with biliary obstruction. Canadian Journal of Gastroenterology. 2009 (in press). Al Ali J, Monk P, Byrne MF. Pancreatic pseudocyst with fistula to the common bile duct resolved by combined biliary and pancreatic stenting-A case report and literature review. Canadian Journal of Gastroenterology 2009 Aug;23(8):557-9. Cheung J, Sawisky G, Enns R, Byrne MF, Zhu Q, Wong CKW. Practices in Peptic Ulcer Bleeding Controversies Among University versus Non-University Affiliated Gastroenterologists. Canadian Journal of Gastroenterology 2009 (in press). Byrne MF, McLoughlin MT, Mitchell RM, Gerke H, Pappas TN, Branch MS, Jowell PS, Baillie J. The fate of patients who undergo “preoperative” ERCP to clear known or suspected bile duct stones. Surg Endosc. 2009; 23 (1): 74-9. Byrne MF. Management of benign biliary strictures. Gastroenterology and hepatology 2008; 4(10):694-7. Farrah M, McLoughlin MT, Byrne MF. “ERCP in the Management of Benign Biliary Strictures” for Current Gastroenterology Reports 2008;10(2):150-6. Wiesinger HAR, Shah J, White A, Yoshida EM, Frolich J, Sirrs S, Gill S, Byrne MF. Liver Biochemistry Abnormalities in a Quaternary Care Lipid Clinic Database. Annals of Hepatology 2008; 7: 63-66. Bressler B, Law JK, Al Nahdi Sheraisher N, Atkinson K, Byrne MF, Chung HV, Fishman M, Partovi N, Pearson D, Penner R, Enns RA. The use of infliximab for treatment of hospitalized patients with acute severe ulcerative colitis. Can J Gastroenterol. 2008 Nov;22(11):937-40. McLoughlin MT, Byrne MF. Endoscopic stenting: where are we now and where can we go? World J Gastroenterol. 2008 Jun 28;14(24):3798-803. Byrne MF, Chiba N, Singh H, Sadowski DC; Clinical Affairs Committee of the Canadian Association of Gastroenterology. Propofol use for sedation during endoscopy in adults: a Canadian Association of Gastroenterology position statement. Can J Gastroenterol. 2008 May;22(5):457-9. Farah M, McLoughlin M, Byrne MF. Endoscopic retrograde cholangiopancreatography in the management of benign biliary strictures. Curr Gastroenterol Rep. 2008 Apr;10(2):150-6. Apiratpracha W, Yoshida EM, Scudamore CH, Weiss A, Byrne MF. Chronic Pancreatitis: A Previously Unreported Sequelae of Acute Fatty Liver of Pregnancy. Hepatobiliary and Pancreatic Diseases International 2008; 7: 101-104. Zandieh I, Byrne MF. Autoimmune pancreatitis: A review.World J Gastroenterol. 2007;13(47):6327-32. Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox DM, Byrne MF. The effect of different strains of Helicobacter pylori on platelet aggregation. Can J Gastroenterol. 2007;21(6):367-70. Manning DS, Sheehan KM, Byrne MF, Kay EW, Murray FE. Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. J Gastroenterol Hepatol. 2007;22(10):1633-7. Ho JK, Mahmoudi N, Al-Ali J, Yoshida EM, Byrne MF. Duodenal Varices: A Rare Manifestation of Portal Hypertension. Internet Journal of Gastroenterology 2007; 5.
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Gerke H, Jaffe TA, Mitchell RM, Byrne MF, Stiffler HL, Branch MS, Baillie J, Jowell PS. Endoscopic ultrasound and computer tomography are inaccurate methods of classifying cystic pancreatic lesions. Dig Liver Dis. 2006;38:39-44. Cox D, Maree AO, Dooley M, Conroy R, Byrne MF, Fitzgerald DJ. Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. Stroke. 2006 Aug;37(8):2153-8. Byrne MF. Nonanesthesiologist-administered propofol sedation in endoscopic practice. Gastroenterol Hepatol. 2006;2(6):416-418. Ho JK, Byrne MF. What’s Up in GERD? Canadian Journal of Diagnosis 2005; 22 (3): 87-89. Byrne MF, Power DG, Keeling AN, Kay E, Murray FE, Patchett SE. Combined terminal ileoscopy and biopsy is superior to small bowel follow-through in detecting terminal ileal pathology. Dig Liver Dis. 2004 Feb;36(2):147-52. Sheehan KM, Byrne MF, Murray FE. The seroprevalence of Helicobacter pylori in an Irish university student population. J Infect. 2004 Apr;48(3):283-4. Gerke H, Byrne MF, Xie HB, Paulson EK, Tyler DS, Baillie J, Jowell PS. A wolf in sheep’s clothing: a non-functioning islet cell tumor of the pancreas masquerading as a microcystic (serous cystic) adenoma. Jop. 2004;5:225-230. Gerke H, Byrne MF, Stiffler HL, Obando JV, Mitchell RM, Jowell PS, Branch MS, Baillie J. Outcome of endoscopic minor papillotomy in patients with symptomatic pancreas divisum. Jop. 2004;5:122-131. Sheehan KM, Cahill RA, McGreal G, Steele C, Byrne MF, Kirwan WO, Kay EW, Fitzgerald DJ, Redmond HP, Murray FE. Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. Dig Liver Dis. 2004;36:392-397. Sheehan KM, O’Connell F, O’Grady A, Conroy RM, Leader MB, Byrne MF, Murray FE, Kay EW. The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas. Eur J Gastroenterol Hepatol. 2004;16:619-625. Corcoran PA, Byrne MF. Is the host responsible? -- the role of the immune system in Helicobacter pylori infection. Med Hypotheses. 2004;62(1):95-6. Mitchell RM, Byrne MF. Acute Colonic Pseudo-obstruction (Ogilvie’s syndrome). Emergency Medicine 36(4):27-30, 2004. Gerke H, White R, Byrne MF, Stiffier H, Mitchell RM, Hurwitz HI, Morse MA, Branch MS, Jowell PS, Czito B, Clary B, Pappas TN, Tyler DS, Baillie J. Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage. Dig Liver Dis. 2004;36:412-418. Byrne MF, Mitchell RM, Gerke H, Goller S, Stiffler HL, Golioto M, Branch MS, Jowell PS, Baillie J. The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia. J Clin Gastroenterol. 2004;38:225-229. Byrne MF, Gerke H, Mitchell RM, Stiffler HL, McGrath K, Branch MS, Baillie J, Jowell PS. Yield of endoscopic ultrasound-guided fine-needle aspiration of bile duct lesions. Endoscopy. 2004;36:715-719. Byrne MF, Baillie J. The use of propofol during endoscopy. Gastroenterology 2003; 124 (4): 1162-1163. Baillie J, Byrne MF. ERCP- preparation, position, and instrumentation. Techniques in Gastrointestinal Endoscopy 2003; 5(1): 3-10. Byrne MF, Jowell P. ERCP-methods of tissue sampling. Techniques in Gastrointestinal Endoscopy 2003; 5(1): 27-34. Byrne MF, Agrawal NM. A rationale for appropriate use of selective cyclooxygenase-2 inhibitors instead of NSAIDs based on risk factors for adverse gastrointestinal events. Evidence Based Gastroenterology 2003;4(2):39-40. Byrne MF, Mitchell RM, Baillie J. Management of ingested foreign bodies. Emergency Medicine 2003; 35(5): 55-58. Bohra S, Byrne MF, Smyth C, Manning D, Patchett SE, Murray FE. An audit of consultations in a teaching hospital gastroenterology service. Irish Medical Journal 2003;96(9).
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Byrne MF. Primary screening with colonoscopy for colorectal cancer: a targeted algorithm? Am J Gastroenterol. 2003 Dec;98(12):2587-9. Byrne MF, Murphy JF, Corcoran PA, Atherton JC, Sheehan KM, Cox D, Murray FE, Fitzgerald DJ. Helicobacter pylori induces cyclooxygenase-1 and cyclooxygenase-2 expression in vascular endothelial cells. Scand J Gastroenterol. 2003 Oct;38(10):1023-30. Gerke H, Byrne MF, Jowell PS. Unusual finding in a patient with pancreas divisum and abdominal pain. MedGenMed. 2003 Jul 30;5(3):14. Byrne MF, Royston D, Patchett SE. Association of common variable immunodeficiency with atypical collagenous colitis. Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1051-3. Byrne MF, Suhocki P, Mitchell RM, Pappas TN, Stiffler HL, Jowell PS, Branch MS, Baillie J. Percutaneous cholecystostomy in patients with acute cholecystitis: experience of 45 patients at a US referral center. J Am Coll Surg. 2003 Aug;197(2):206-11. Mitchell RM, Byrne MF. Biliary emergencies: pancreatitis, cholangitis, and more. Semin Gastrointest Dis. 2003 Apr;14(2):77-86. Byrne MF, Baillie J. Predicting the likelihood of therapeutic ERCP. A suggested ‘model’ to limit the number of purely diagnostic ERCPs. Dig Liver Dis. 2003 Jul;35(7):458-60. Byrne MF, Kerrigan SW, Corcoran PA, Atherton JC, Murray FE, Fitzgerald DJ, Cox DM. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation. Gastroenterology. 2003 Jun;124(7):1846-54. Mitchell RM, Byrne MF, Baillie J. Colonoscopy or barium enema for population colorectal cancer screening? Dig Liver Dis. 2003 Apr;35(4):207-11. Mitchell RM, Byrne MF, Baillie J. Pancreatitis. Lancet. 2003 Apr 26;361(9367):1447-55. Byrne MF, Chong HI, O’Donovan D, Sheehan KM, Leader MB, Kay E, McCormick PA, Broe P, Murray FE, McCormack A. Idiopathic cholangiopathy in a biliary cast syndrome necessitating liver transplantation following head trauma. Eur J Gastroenterol Hepatol. 2003 Apr;15(4):4157. Sheehan KM, O’Donovan DG, Fitzmaurice G, O’Grady A, O’Donoghue DP, Sheahan K, Byrne MF, Conroy RM, Kay EW, Murray FE. Prognostic relevance of Fas (APO-1/CD95) ligand in human colorectal cancer. Eur J Gastroenterol Hepatol. 2003 Apr;15(4):375-80. Byrne MF, McVey G, Royston D, Patchett SE. Association of Clostridium difficile infection with collagenous colitis. J Clin Gastroenterol. 2003 Mar;36(3):285. Shah AA, Byrne MF, Cullen L, Walsh T, Fitzgerald DJ, Murray FE. Effect of H. pylori infection on the expression of cyclooxygenase-2 in human gastric mucosa. Prostaglandins Leukot Essent Fatty Acids. 2003 Jan;68(1):1-8. Byrne MF. Primary screening for colorectal cancer using colonoscopy: a targeted algorithm? American Journal of Gastroenterology 2003;98(12):2587-2589. Bohra S, Byrne MF, Manning D, Smyth C, Patchett SE, Murray FE. A prospective analysis of inpatient consultations to a gastroenterology service. Ir Med J. 2003 Oct;96(9):263-5. Byrne MF, Jowell P. Clinical applications of endoscopic ultrasound. Gastroenterology 2002; 122 (6): 1631-1648. Kerrigan SW, Douglas I, Wray A, Heath J, Byrne MF, Fitzgerald DJ, Cox D. A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation. Blood 2002; 100 (2): 509-516. Byrne MF, Corcoran PA, Atherton JC, Sheehan KM, Murray FE, Fitzgerald DJ, Murphy JF. Stimulation of adhesion molecule expression by Helicobacter pylori and increased neutrophil adhesion to human umbilical vein endothelial cells. FEBS Letters 2002; 532(3): 411-414. Byrne M, Sheehan K, Kay E, Patchett S. Symptomatic ulceration of an acid-producing oesophageal inlet patch colonised by Helicobacter pylori. Endoscopy 2002; 34 (6): 514. Byrne MF, Mitchell RM, Stiffler HL, Jowell PS, Branch MS, Pappas TN, Tyler D, Baillie J. Extensive investigation of patients with mild elevations of serum amylase and/or lipase is “low yield”. Canadian Journal of Gastroenterology 2002; 16 (12): 849-854.
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Smyth C, Manning D, Byrne MF, Murray FE. Hepatitis C infection in plasmapheresis donors an overlooked risk factor for transmission? European Journal of Gastroenterology and Hepatology 2002; 14(8): 891-892. Byrne MF, Murray FE, Lee MJ. Use of Doppler Ultrasound of the SMA for Crohn’s Disease Activity Evaluation in Clinical Practice. Clinical Radiology 2002; 57 (6): 538. Byrne MF, Mitchell RM, Baillie J. Uncommon biliary strictures. Techniques in Gastrointestinal Endoscopy 2002; 4 (3): 157-163. Byrne MF, Ryan A, Sheehan KM, Patchett SE. Disabling osteomalacic myopathy as the only presenting feature of coeliac disease. European Journal of Gastroenterology and Hepatology 2002; 14 (11): 1271-1274. Byrne MF, Mitchell RM, Baillie J. Pancreatic Pseudocysts. Current Treatment Options in Gastroenterology 2002; 5 (5): 331-338. Byrne MF, McVey G, Abdulla K, Patchett SE. Successful Endoscopic Management of Subacute Intestinal Obstruction Presenting Three Years after Lodgement of a Coin in the Duodenal Cap. Endoscopy 2002; 34: 594. Byrne MF. Interactions between Helicobacter pylori, cyclooxygenase, platelets and adhesion molecules in gastric and vascular models. MD thesis. Cambridge University, 2002. Byrne MF, Mitchell RM, Baillie J. Common Bile Duct Stones. Emergency Medicine 2002; 34 (10): 54-63. Byrne MF, McGuiness J, Smyth CM, Manning DS, Sheehan KM, Bohra SG, Patchett SE, Murray FE. NSAID induced diaphragms and ulceration in the colon. European Journal of Gastroenterology and Hepatology 2002; 11 (4): 1265-1269. Byrne MF, Farrell MA, Abass S, Varghese JC, Fitzgerald A, Thornton F, Murray FE, Lee MJ. Assessment of Crohn’s disease activity by Doppler sonography of the superior mesenteric artery, clinical evaluation and the Crohn’s disease activity index—a prospective study. Clinical Radiology 2001; 56(12): 973-978. Byrne MF, Murray FE. Formulary management of proton pump inhibitors. Pharmacoeconomics 1999; 16(3): 225-246. Byrne MF, Murray FE. Current views on Helicobacter pylori eradication therapy. Irish Medical Journal 1998; 91(1): 8-10.
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Lynd LD, Najafzadeh M, Colley L, Byrne MF, Willan AR, Sculpher MJ, Johnson FR, Hauber AB. Using the Incremental Net Benefit Framework for Quantitative Benefit-Risk Analysis in Regulatory Decision-Making-A Case Study of Alosetron in Irritable Bowel Syndrome. Value Health. 2009 Sep 10. Corcoran PA, McGuane DE, McGrath AM, Burke CM, Byrne MF. Med Hypotheses. Blood group O and vWf expression may be involved in development of peptic ulcer disease secondary to Helicobacter pylori infection. 2009 Sep;73(3):338-9. Epub 2009 May 6. Al Ali JA, Chung H, Munk PL, Byrne MF. Pancreatic pseudocyst with fistula to the common bile duct resolved by combined biliary and pancreatic stenting -- a case report and literature review. 2009 Aug;23(8):557-9. Byrne MF. Nurse-administered propofol sedation safety further confirmed - but can we really allow our patients to drive afterwards? Digestion 2008; 78(4): 187-9. Byrne MF. Gallstone pancreatitis-Who really needs an ERCP? Can J Gastroenterol. 2006;20:15-17. Byrne MF. “Wake me up before you go-go”. Drug, ‘wham’, scope, then snooze. Can’t we do better with conscious sedation for endoscopy? Can J Gastroenterol. 2006 Dec;20(12):767-9. Shah JA, Byrne MF. Refractory GERD. Consultant, 2006.
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Byrne MF, Baillie J. Nurse-assisted propofol sedation: the jury is in! Gastroenterology. 2005;129:1781-1782. Byrne MF. Percutaneous cholecystostomy. CME program. Journal of the American College of Surgeons 2003;197(2):343-345. Byrne MF. Small bowel follow through and terminal ileoscopy. Endoscopy and gastroenterology news 2002. Byrne MF, Baillie J. Propofol for conscious sedation? Gastroenterology 2002, 123 (1): 373375. Byrne MF. The curse of poor bowel preparation for colonoscopy. American Journal of Gastroenterology 2002; 97 (7): 1587-1590. Byrne MF, McWilliams S, Patchett SE. Patient information booklet on inflammatory bowel disease. September 2001. Byrne MF, O’Donoghue D. Helicobacter pylori eradication an update. Irish Medical Times, August 1997. Byrne MF, O’Donoghue D. Management of dyspepsia. Irish Medical News. June 1997. (b) Conference Proceedings
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Chan CHY, Donnellan F, Byrne MF, Coss A, Scudamore CH, Steinbrecher UP, Weiss A, Yoshida EM. Endoscopic management of anastomotic strictures in deceased versus living donor liver transplantation. DDW, May 2012. Poster. Chan CHY, Donnellan F, Byrne MF, Coss A, Scudamore CH, Steinbrecher UP, Weiss A, Yoshida EM. Endoscopic management of anastomotic strictures in deceased versus living donor liver transplantation. CDDW, Feb 2012. Poster. Donnellan F, Enns R, Kim E, Lam E, Amar J, Telford J, Byrne MF. Outcome of repeat ERCP after initial failed use of a needle knife for biliary access. Poster Presentation, DDW, Chicago, 2011. Donnellan F, Byrne MF, Moosavi S, Lam E, Amar J, Telford J, Enns R. Efficacy and safety of endoscopic balloon sphincteroplasty for removal of large bille duct stones. Poster Presentation, CDDW, Vancouver, 2011. Abstracts
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Chan CHY, Donnellan F, Coss A, Kim E, Scudamore CH, Steinbrecher UP, Weiss A, Yoshida EM, Byrne MF. Characteristics and outcomes of Early versus late Anastomotic biliary Strictures in Liver Transplantation. DDW 2012. Stylet Use does not affect Adequacy of Specimen of Pancreatic EUS FNA: A prospective, single blinded, randomized, control trial. Chin MW, Coss A, McLoughlin M, Byrne M, Enns RA, Telford JJ, Lam EC. Stylet Use does not affect Adequacy of Specimen of Pancreatic EUS FNA: A prospective, single blinded, randomized, control trial. Presented at DDW 2010. Gastroenterology supplement, DDW proceedings, May 2010. H Wiesinger, A Coss, M Haque, CH Scudamore, UP Steinbrecher, SW Chung, AK Buczkowski, EM Yoshida, MF Byrne. Endoscopic retrograde cholangiopancreatography in the management of biliary complications following liver transplantation: a review of local practice and outcomes. Can J Gastroenterology, A263, Vol 24, Suppl A, February 2010. Wiesinger, A Coss, M Haque, CH Scudamore, UP Steinbrecher, SW Chung, AK Buczkowski, EM Yoshida, MF Byrne. Endoscopic retrograde cholangiopancreatography in the management of biliary complications following liver transplantation: a review of local practice and outcomes. HCDDW 2010. McLoughlin MT, Kim EY, Lam EC, Byrne MF, Telford JJ, Amar J, Enns RA. “A Prospective Evaluation of Fluoroscopy Time At ERCP” Gastrointestinal Endoscopy April 2009 (Vol. 69,
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Issue 5, Page AB234). DDW, June 2009. McLoughlin MT, Kim EY, Lam EC, Byrne MF, Telford JJ, Amar J, Enns RA. “A Prospective Evaluation of Fluoroscopy Time At ERCP”. Can J Gastroenterol 2009; Vol 23, Suppl A, P83. Singham J, Byrne MF. A case report of Rothmund-Thomson syndrome: is this a previously unrecognized feature of the syndrome? GRIT course 2009. Sawisky G, Cheung J, Enns R, Byrne MF, Marcon N. Management of acute peptic ulcer bleeding: a nationwide Canadian survey. CDDW 2008. Kim E, Mcloughlin MT, Lam E, Byrne MF, Telford J, Amar J, Enns R. “Radiation exposure during ERCP- critical determinants”.Gastrointestinal Endoscopy 2008; 67(5): ab234-5. Sawisky G, Cheung J, Enns R, Byrne MF, Marcon N. Management of acute peptic ulcer bleeding: a nationwide Canadian survey. DDW 2008. Kim E, McLoughlin MT, Lam E, Byrne MF, Telford J, Amar J, Enns R. “Radiation Exposure during ERCP- Critical Determinants”. CDDW 2008. Shah J, Wiesinger H, White, A, Byrne MF, Yoshida EM, Frolich J . Liver biochemistry abnormalities in a quaternary care lipid clinic database. Can J Gastroenterol Vol 21 (supplement A-237) Feb 2007. White AS, Shah J, Wiesinger HAR, Elliott T, Gill S, Sirrs S, Yoshida EM, Byrne MF. Retrospective analysis of the role of type 2 diabetes mellitus and therapy using a thiazolidinedione on the presence and subsequent control or resolution of nonalcoholic steatohepatitis. Can J Gastroenterol Vol 21 (supplement A-239) Feb 2007. Al Ali J, Byrne MF, Enns R. Histoacryl injection of gastric varices. Experience in a Canadian University Hospital practice. Gastroenterology(supplement) May 2006. Ho JK, Mahmoudi N, Al Ali J, Yoshida EM, Byrne MF. Duodenal Varices Are a Rare But Potentially Serious Consequence of Portal Hypertension in the Event of a Bleed. American Journal of Gastroenterology 2005; 100 Supl: S221 (abstract). Corcoran PA, Cox D, Atherton JC, Kerrigan SW, Peek RM, Fitzgerald DJ, Murray FE, Byrne MF. Helicobacter pylori and Platelet Aggregation. Results of Screening 26 Bacterial Strains. Gastroenterology 2004; 126(4): A-404. Gerke H, Jaffe TA, Mitchell RM, Byrne MF, Stiffler H, Branch MS, Baillie J, Jowell PS. Endoscopic Ultrasound and Computer Tomography are Inaccurate Methods of Classifying Cystic Pancreatic Lesions. Gastrointestinal Endoscopy 2004. Corcoran PA, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE, Byrne MF. Specific serum antibodies are involved in H. pylori-induced platelet aggregation. Gut 2003; 52 (suppl 1): A53. Corcoran PA, Kerrigan S, Cox D, Atherton JC, Fitzgerald DJ, Murray F, Byrne MF. Specific serum antibodies are involved in H. pylori-induced platelet aggregation. Gastroenterology 2003; 124 (suppl 1): A-148. Bohra SK, Manning D, Byrne MF, Patchett S, Murray F. Utility of Selective Organic Symptoms in the Diagnosis of Chronic Diarrhoea. Gastroenterology 2003; 124 (suppl 1): A-144. Byrne MF, Kim LK, Pappas TN, Gerke H, Mitchell RM, Stiffler HL, Branch MS, Jowell PS, Baillie J. In Patients (pts) with Predicted Low Risk for Choledocholithiasis undergoing Laparoscopic Cholecystectomy (LC), Selective Intraoperative Cholangiography (IOC) and Post-Operative ERCP is an Effective Strategy to Limit Unnecessary Procedures. Gastrointestinal Endoscopy 2003; 57(5): AB193. Gerke H, White R, Stiffler HL, Mitchell RM, Byrne MF, Hurwitz HI, Baillie J, Branch MS, Jowell PS, Clary BM, Pappas TN, Tyler DS. Preoperative Biliary Drainage Does Not Increase Wound Infections or Intra-abdominal Abscesses in Patients Undergoing Pancreaticoduodenectomy (Whipple Procedure) for Periampullary Cancer. Gastrointestinal Endoscopy 2003; 57(5): AB189. Byrne MF, Mitchell RM, Gerke H, Pappas TN, Stiffler HL, Branch MS, Jowell PS, Baillie J. The Fate of Patients who Undergo “Preoperative” ERCP to Clear Known or Suspected Bile Duct Stones. Gastrointestinal Endoscopy 2003; 57(5): AB194. Mitchell RM, Stiffler HL, Byrne MF, Gerke H, Jowell PS, Branch MS, Baillie J. Biliary Manometry is a Low-Yield Investigation in Patients With Recurrent “Biliary Pain” After
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Endoscopic Biliary Sphincterotomy [EBS], but Recurrent Pancreatitis in This Population May Reflect Previously Undiagnosed Pancreatic Sphincter Hypertension. Gastrointestinal Endoscopy 2003; 57(5): AB202. Byrne MF, Gerke H, Mitchell RM, Stiffler HL, Branch MS, Baillie J, Jowell PS. Yield of Endoscopic Ultrasound Guided Fine Needle Aspiration of Bile Duct Lesions. Gastrointestinal Endoscopy 2003; 57(5): AB237. Hilliard M, Harhen B, Devocelle M, Aftab A, Byrne MF, Murray F, Fitzgerald D. Generation of Anti-inflammatory Prostaglandin PGJ2 in Inflammatory Bowel Disease. Gastroenterology 2003; 124 (suppl 1): A-335. Bohra S, Manning D, Byrne MF, Patchett SE, Murray FE. Utility of accurate history taking in the diagnosis of chronic diarrhoea. Irish Society of Gastroenterology, November 2002. Byrne MF, Suhocki P, Mitchell RM, Pappas TN, Stiffler HL, Jowell PS, Branch MS, Baillie J. Percutaneous cholecystectomy in patients with acute cholecystitis—experience of 45 patients at a US referral center. American College of Gastroenterology, Seattle, October 2002. Mitchell RM, Byrne MF, Stiffler HL, Jowell PS, Branch MS, Baillie J. Diagnosis of choledochal cysts (CDC) in adults: 9-year experience at a tertiary medical center (DUMC). American College of Gastroenterology, Seattle, October 2002. Sheehan KM, O’Connell F, O’Grady A, Byrne MF, Leader MB, Kay EW, Murray FE. Cyclooxygenase-2 expression and dysplasia in human colorectal adenomatous polyps. British Society of Gastroenterology, Birmingham, March 2002. Bohra S, Byrne MF, Manning D, Smyth C, Patchett SE, Murray FE. A prospective study of gastroenterology consultations in an urban teaching hospital. British Society of Gastroenterology, Birmingham, March 2002. Power DG, Keeling AN, Byrne MF, Kay EW, Murray FE. Utility of terminal ileal (TI) biopsies at routine colonoscopy. British Society of Gastroenterology, Birmingham, March 2002. Corcoran P, Sheehan K, Steele C, Atherton J, Fitzgerald D, Murray F, Byrne MF. Role of Transcription Factor NF-kB in Cyclooxygenase-2 Promoter Induction by Helicobacter Pylori in Endothelial Cells. British Society of Gastroenterology, Birmingham, March 2002. Corcoran P, Kerrigan S, Cox D, Atherton J, Fitzgerald D, Murray F, Byrne MF. A Role for Von Willebrand Factor in Helicobacter Pylori-Induced Platelet Aggregation. British Society of Gastroenterology, Birmingham, March 2002. Byrne MF, McGuinness J, Smyth C, Manning D, Bohra S, Sheehan K, Patchett S, Murray F. NSAID Induced Diaphragms and Ulceration in the Colon. Gastrointestinal Endoscopy 2002; 55(5): AB265. Corcoran P, Sheehan K, Steele C, Atherton J, Fitzgerald D, Murray F, Byrne MF. Role of Transcription Factor NF-kB in Cyclooxygenase-2 Promoter Induction by Helicobacter Pylori in Endothelial Cells. Gastroenterology 2002; 122(4): A-406. Corcoran P, Kerrigan S, Cox D, Atherton J, Fitzgerald D, Murray F, Byrne MF. A Role for Von Willebrand Factor in Helicobacter Pylori-Induced Platelet Aggregation. Gastroenterology 2002; 122(4): A-428. Byrne MF, Power D, O’Gara A, Keeling A, Kay E, Murray F, Patchett S. Combined Terminal Ileoscopy and Biopsy is Superior to Small Bowel Follow Through in Detecting Terminal Ileal Pathology. Gastroenterology 2002; 122(4): A-217. Manning DS, Sheehan KM, Byrne MF, Kay EW, Murray FE. Cyclooxygenase-2 Expression in Chronic Hepatitis C Infection Pre and Post Treatment with Interferon. Gastroenterology 2002; 122(4): A-678. Byrne MF, Stiffler HL, Jowell PS, Branch MS, Pappas TN, Tyler D, Baillie J. Extensive Investigation of Patients with Mild Elevations of Serum Amylase +/- Lipase Is “Low Yield” and Not Cost-Effective. Gastrointestinal Endoscopy 2002; 55(5): AB83. Byrne MF, Stiffler HL, Branch MS, Jowell PS, Baillie J. The Need for Repeat Procedures within 30 Days in Patients Stented for Malignant Distal Biliary Strictures (MDBS): Experience of 508 Patients at a US Referral Center. Gastrointestinal Endoscopy 2002; 55(5): AB186. Sheehan KM, O’Connell F, O’Grady A, Byrne MF, Leader MB, Murray FE, Kay EW. Cyclooxygenase-2 expression and dysplasia in human colorectal adenomatous polyps. Irish
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Society of Gastroenterology, November 2001. Byrne MF, McGuinness J, Smyth C, Manning D, Bohra S, Sheehan K, Patchett S, Murray F. NSAID Induced Diaphragms and Ulceration in the Colon. Irish Society of Gastroenterology, November 2001. Hilliard MJ, Byrne MF, Aftab AR, Sheehan KM, Murray FE, Fitzgerald DJ. Generation of the anti-inflammatory prostaglandin PGJ2 in vitro and ex vivo and a possible role as an antiinflammatory agent in IBD. Irish Society of Gastroenterology, November 2001. Byrne MF, Corcoran PA, Kerrigan SW, Atherton JC, Fitzgerald DJ, Cox D, Murray FE. The interactions between Helicobacter pylori and the vasculature-implications for gastric pathogenesis and cardiovascular risk. Irish Society of Gastroenterology, June 2001. Corcoran PA, Murphy J, Sheehan KM, Atherton JC, Kerrigan SW, Cox D, Fitzgerald DJ, Murray FE, Byrne MF. The interactions between Helicobacter pylori and the vasculatureimplications for gastric pathogenesis and cardiovascular risk. Royal College of Surgeons in Ireland, Book of Abstracts, April 2001: C8. Sheehan KM, Power DG, Steele C, Byrne MF, Doherty E, Murray FE. The relationship between utilisation of healthcare resources and psychological factors in patients with inflammatory bowel disease. Gastroenterology 2001; 120 (6) (Suppl 2). Byrne MF, Corcoran PA, Kerrigan SW, Atherton JC, Kenny D, Fitzgerald DJ, Cox D, Murray FE. Mechanisms of H. pylori induced platelet aggregation--cosignalling between platelet GPIb and FC?RIIa receptors but no role for platelet activating factor. Gastroenterology 2001; 120 (6) (Suppl 2). Byrne MF, Corcoran PA, Murphy J, Sheehan KM, Atherton JC, Kerrigan SW, Cox D, Fitzgerald DJ, Murray FE. The interactions between Helicobacter pylori and the vasculatureimplications for gastric pathogenesis and cardiovascular risk. Irish Journal of Medical Science 2001; 170 (1) (Suppl 2). Byrne MF, Corcoran PA, Sheehan KM, Atherton JC, Fitzgerald DJ, Murphy, FE Murray. Stimulation of P-selectin, E-selectin and cellular adhesion molecule expression by H pylori in endothelial cells mediates increased neutrophil adhesion. Gastroenterology 2001; 120 (6) (Suppl 2) A3627. Byrne MF, Corcoran PA, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. The time course of transcriptional regulation of the ‘constitutive’ cyclooxygenase-1 gene by H pylori. Gastroenterology 2001; 120 (6) (Suppl 2) A3570. Byrne MF, Corcoran PA, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Effect of different strains of Helicobacter pylori on cyclooxygenase-2 promoter activity – Vac A and Cag A are not involved. Gastroenterology 2001; 120 (6) (Suppl 2) A3628. Byrne MF, Corcoran PA, Atherton JC, Fitzgerald DJ, Murray FE. Effect of different strains of Helicobacter pylori on cyclooxygenase-2 promoter activity--vacA and cag A not involved. Gut 2001; 48 (Suppl I): A69. Byrne MF, Kerrigan SW, Corcoran PA, Atherton JC, Cox D, Fitzgerald DJ, Murray FE. Mechanisms of H. pylori induced platelet aggregation--cosignalling between platelet GPIb and FC?RIIa receptors but no role for platelet activating factor. Gut 2001; 48 (Suppl I): A70. Byrne MF, Murphy JF, Corcoran PA, Fitzgerald DJ, Murray FE. Helicobacter pylori increases endothelial selectin and cellular adhesion molecule expression and neutrophil adhesion. Gut 2001; 48 (Suppl I): A69. Byrne MF, Corcoran PA, Atherton JC, Fitzgerald DJ, Murray FE. Transcriptional regulation of the ‘constitutive’ cyclooxygenase-1 gene by Helicobacter pylori. Gut 2001; 48 (Suppl I): A69. Corcoran PA, Byrne MF, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. A role for platelet glycoproteins in Helicobacter pylori induced platelet aggregation. Irish Association of Pharmacologists, October 2000. Byrne MF, Kerrigan SW, Corcoran PA, Kenny D, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. Cardiovascular disease and Helicobacter pylori--relevance of H. pylori induced platelet aggregation? Irish Cardiac Society, September 2000. Byrne MF, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Evidence of transcriptional regulation of the cyclooxygenase-2 promoter by Helicobacter pylori in gastrointestinal cancer
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cells. Royal College of Surgeons in Ireland, Book of Abstracts, April 2000: P39. Byrne MF, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Evidence of transcriptional regulation of the cyclooxygenase-2 promoter by Helicobacter pylori in gastrointestinal cancer cells. National Scientific Medical Meeting, Mar 2000. Ir J Med Sci 2000; 169 (1) (Suppl 2): P5. Byrne MF, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. Strain specific Helicobacter pylori induced platelet aggregation: implications for gastric pathogenesis. National Scientific Medical Meeting, Registrar’s prize, Mar 2000. Ir J Med Sci 2000; 169 (1) (Suppl 2). Byrne MF, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. Strain specific Helicobacter pylori induced platelet aggregation: a pivotal role for glycoprotein Ib. Gastroenterology 2000; 118 (5) (Suppl 2). Byrne MF, Kerrigan SW, Corcoran P, Kenny D, Cox D, Murray FE, Fitzgerald DJ. Cardiovascular disease and Helicobacter pylori -– relevance of H. pylori induced platelet aggregation? Circulation 2000; 931 (suppl 1). Byrne MF, Fitzgerald DJ, Atherton JC, Murray FE. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. Gut 2000; 46 (Suppl 11): W101. Byrne MF, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Evidence of transcriptional regulation of the cyclooxygenase-2 promoter by Helicobacter pylori in gastrointestinal cancer cells. Gut 2000; 46 (Suppl 11): W102. Byrne MF, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. Helicobacter pylori induces platelet aggregation in vitro: mechanism of action and strain specificity. Gut 2000; 46 (Suppl 11): W25. Sheehan KM, Byrne MF, Kenealy MR, Fitzgerald DJ, Murray FE. Transcriptional regulation of cyclooxygenase-2 in gastrointestinal cancer cells. Gut 2000; 46 (Suppl 11): W166. Byrne MF, Fitzgerald DJ, Atherton JC, Murray FE. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. National Scientific Medical Meeting, Mar 2000. Ir J Med Sci 2000; 169 (1) (Suppl 2): P4. Byrne MF, Fitzgerald DJ, Atherton JC, Murray FE. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. Royal College of Surgeons in Ireland, Book of Abstracts, April 2000: P12. Byrne MF, Kerrigan SW, Cox D, Atherton JC, Fitzgerald DJ, Murray FE. Strain specific Helicobacter pylori induced platelet aggregation: a pivotal role for glycoprotein Ib. Royal College of Surgeons in Ireland, Book of Abstracts, April 2000: P38. Byrne MF, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Evidence of transcriptional regulation of the cyclooxygenase-2 promoter by Helicobacter pylori in gastrointestinal cancer cells. Gastroenterology 2000; 118 (5) (Suppl 2). Byrne MF, Fitzgerald DJ, Atherton JC, Murray FE. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. Gastroenterology 2000; 118 (5) (Suppl 2). Sheehan KM, Byrne MF, Kenealy MR, Fitzgerald DJ, Murray FE. Transcriptional regulation of cyclooxygenase-2 promoter activity in gastrointestinal cancer cells. Gastroenterology 2000; 118 (5) (Suppl 2). Byrne MF, Murphy JF, Fitzgerald DJ, Murray FE. Endothelial cell adhesion molecules are induced by Helicobacter pylori. Ir J Med Sci 2000; 169 (3) (Suppl 3). Byrne MF, Corcoran PA, Atherton JC, Fitzgerald DJ, Murray FE. The promoter of the ‘constitutive’ cyclooxgenase-1 gene is driven by Helicobacter pylori. Ir J Med Sci 2000; 169 (3) (Suppl 3). Byrne MF, Fitzgerald DJ, Atherton JC, Murray FE. Helicobacter pylori induces cyclooxygenase-1 as well as cyclooxygenase-2 in endothelial cells. Gut 2000; 47 (Suppl III). Byrne MF, Sheehan KM, Atherton JC, Fitzgerald DJ, Murray FE. Regulation of the promoters of both cylcooxygenase-1 and -2 by Helicobacter pylori in gastrointestinal cancer cells. Gut 2000; 47 (Suppl III). Byrne MF, Kerrigan SW, Corcoran P, Kenny D, Atherton JC, Cox D, Murray FE, Fitzgerald
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DJ. Mechanisms of platelet aggregation induced by Helicobacter pylori. Gut 2000; 47 (Suppl III). Sheehan KM, Byrne MF, Fitzgerald DJ, Murray FE. Differential cyclooxygenase-2 expression and regulation in colorectal cancer cells. Gut 2000; 47 (Suppl III). Byrne MF, Murphy JF, Fitzgerald DJ, Murray FE. Endothelial cell adhesion molecules are induced by Helicobacter pylori.(poster of distinction) Gut 2000; 47 (Suppl III). Sheehan KM, Steele C, Byrne MF, O’Gara A, Kelly A, Doherty E. Personality factors are important predictors of psychological morbidity in patients with inflammatory bowel disease. Gut 2000; 47 (Suppl III). Sheehan KM, Fitzmaurice G, O’Grady T, O’Donovan D, Byrne MF, Conroy R, Sheahan K, O’Donoghue D, Kay E, Murray FE. Fas ligand expression: clinicopathological features and patient outcome in human colorectal cancer. Gut 2000; 47 (Suppl III). Sheehan KM, Kenealy MR, Byrne MF, Murray FE, Fitzgerald DJ. Regulation of cyclooxygenase-2 transcription in gastrointestinal cancer cells. Royal College of Surgeons in Ireland, Book of Abstracts, April 1999: P39. Byrne MF, Farrell MA, Abass S, Varghese JC, Lee MJ, Murray FE. Comparison of Crohn’s disease activity assessment by Doppler ultrasound of superior mesenteric artery and other methods. Royal College of Surgeons in Ireland, Book of Abstracts, April 1999: P6. Byrne MF, Harhen B, Fitzgerald DJ, Murray FE. Assessment of 15-HETE production by Cyclooxygenase-2 in gastric mucosa. Royal College of Surgeons in Ireland, Book of Abstracts, April 1999: P36. Sheehan KM, Kenealy MR, Byrne MF, Murray FE, Fitzgerald DJ. Regulation of cyclooxygenase-2 transcription in gastrointestinal cancer cells. Gut 1999; 45 (Suppl V): A246. Byrne MF, Farrell MA, Abass S, Varghese JC, Lee MJ, Murray FE. Comparison of Crohn’s disease activity assessment by Doppler ultrasound of superior mesenteric artery and other methods. Gut 1999; 45 (Suppl V): A198. Byrne MF, Sheehan KM, Fitzgerald DJ, Murray FE. Regulation of Cyclooxygenase-2 promoter activity by Helicobacter pylori in gastrointestinal cancer cells. Ir J Med Sc 1999; 168 (Suppl 9): 8. Byrne MF, Fitzgerald DJ, Murray MF. Upregulation of Cyclooxygenase-1 in endothelial cells by Helicobacter pylori. Ir J Med Sc 1999; 168 (Suppl 9): 23. Byrne MF, Kerrigan SW, Cox D, Fitzgerald DJ, Murray FE. Evidence of strain specific Helicobacter pylori induced platelet aggregation; Implications for gastric pathogenesis and a role for Cyclooxygenase-1. Ir J Med Sc 1999; 168 (Suppl 9): 22. Byrne MF, Farrell MA, Abass S, Varghese JC, Lee MJ, Murray FE. Activity of Crohn’s disease evaluated by Doppler sonography of the superior mesenteric artery. Gut 1999; 44 (suppl 1): T135. Sheehan KM, Kenealy MR, Byrne MF, Murray FE, Fitzgerald DJ. Transcriptional regulation of cyclooxygenase-2 in gastrointestinal cancer cells. Ir J Med Sc 1999; 168 (Suppl 5): 7. Byrne MF, Farrell MA, Abass S, Varghese JC, Lee MJ, Murray FE. Comparison of Crohn’s disease activity assessment by Doppler ultrasound of superior mesenteric artery and other methods. Ir J Med Sc 1999; 168 (Suppl 5): 12. Byrne MF, Sheehan KM, Fitzgerald DJ, Murray FE. Comparison of Cyclooxygenase isoform expression in selected colorectal and gastric cancer lines. Ir J Med Sc 1999; 168 (Suppl 5): 12. Byrne MF, Harhen B, Fitzgerald DJ, Murray FE. Assessment of 15-HETE production by Cyclooxygenase-2 in gastric mucosa. Gut 1999; 45 (Suppl V): A90. Byrne MF, Farrell MA, Abass S, Varghese JC, Lee MJ, Murray FE. Activity of Crohn’s disease evaluated by Doppler sonography of the superior mesenteric artery. Gastroenterology 1999; 116 (4) part 2: A443.
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Byrne MF, Farrell MA, Varghese JC, Lee MJ, Murray FE. A pilot study on the activity of Crohn’s disease evaluated by Doppler sonography of the superior mesenteric artery. Ir J Med Sc 1998; 167(Suppl 7): 18. Byrne MF, Harhen B, Fitzgerald DJ, Murray FE. Assessment of 15-HETE production by Cyclooxygenase-2 in gastric mucosa. Ir J Med Sc 1998; 167 (Suppl 11): 18. (c) Other Review
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Chin MW, Byrne MF. Update of cholangioscopy and biliary strictures. World J Gastroenterol. 2011 Sep 14;17(34):3864-9. Review.
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Tso M, Wu E, Farrah M, Yoshida EM, Byrne MF, Li G. Gastroenterology. In: Essentials for the Canadian Medical Licensing Exam. Jeeshan Chowdry, Shaheed Merani (Ed). Wolters Kluwer/Lippincott Williams & Wilkins Inc. Philadelphia PA. 2009, p218-266. (invited book chapter). Micames C, Byrne MF, Baillie J. Lower Gastrointestinal Bleeding. In Bayless TM and Diehl AM eds. Advanced Therapy of Gastroenterology and Liver Disease 2004. Byrne MF, Mitchell RM, Baillie J. Complications of Endoscopy. In Johnson LR, ed. Encyclopedia of Gastroenterology, Academic Press, CA, 2003. Byrne MF, Baillie J. Acute pancreatitis: pancreatic fluid collections and pseudocysts. In Forsmark CE and Wu G, eds. Pancreatitis and its complications. Humana Press, NJ, 2003. Byrne MF, Murray FE. Gallstones in intestinal failure. In Nightingale JMD, ed. Intestinal Failure. pp 213-226. Greenwich Medical Media Ltd, London, 2000.
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Byrne MF. Best Health magazine (a Canadian Reader’s Digest publication). The best remedies for constipation. October 2012. Buy-o-logic, Oprah Winfrey Network. Televised colonoscopy-procedure performed by MF Byrne. June 2012. Byrne MF. CTV for the Rhonda Low segment on “GI stents treat blockages in the colon prior to colon surgery – or in other areas of the GI tract”. Mayo Clinic Research Shows Minimally Invasive Treatment for Bowel Obstruction is Effective. Sept 2010 . Vancouver Sun article, November 2006, on approval by Health Canada of Remicade for Ulcerative Colitis, “a new therapy for a devastating disease. Work on H. pylori and platelet aggregation was the focus of a media release at a news conference at the American Heart Association in New Orleans in November 2000 and was reported by CNN, USA Today, and several other media publications. This work was also the lead article in the “Science Today” section in the Irish Times in November 2000. Review article on Pancreatitis published in the Lancet 2003 was highlighted by MSNBC.
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