Curriculum Vitae

PERSONAL INFORMATION

Christiane De Boeck

WORK EXPERIENCE 1977–1980

Pediatric Resident University of leuven, (Belgium)

1980–1982

Clinical and research fellow in pediatric pulmonology McGill University Montreal, (Canada)

1982–1983

Research fellow in pediatric pulmonology University of Manitoba, (Canada)

1983–1984

Pediatric Resident University of British Columbia, (Canada)

1984–1987

Adjunct Supervisor University Hospital Leuven, (Belgium)

1987–Present

Adjunct clinical head University Hospital Leuven, (Belgium)

1992–Present

Docent University of Leuven, (Belgium)

1995–Present

Associate Professor University of Leuven, (Belgium)

1999–Present

Full professor University of Leuven, (Belgium)

2001–Present

Clinic Head University of Leuven, (Belgium)

EDUCATION AND TRAINING –1973

Candidate in medicine University of Leuven, (Belgium)

–1977

Doctor in medecin University of Leuven, (Belgium)

–1977

ECFMG ECFMG Brussels, (Belgium)

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Curriculum Vitae

–1982

Christiane De Boeck

VQE VQE, Toronto, (Canada)

–1982

Pediatric subspeciality University of Leuven, (Belgium)

–1983

Evaluating examination Winnipeg, (Canada)

–1983

Certificatin in advanced cardiac llife support

–1984

Fellow of the Royal College of Physicians and Surgeons (Canada)

–1987

Special doctorat in Pediatrics (Belgium)

ADDITIONAL INFORMATION Expertise

Cystic Fibrosis Asthma Infectious Diseases

Publications

2014 MASEKELA R, ANDERSON R, DE BOEK K, VREYS M, STEEL HC, OLURUNJU S, GREEN RJ. Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and Non-CF bronchiectasis. Pediatr Pulmonol, 2014 Oct 27 doi: 10.1002/ppul.23121 Epub ahead of print DE BOECK K, MUNCK A, WALKER S, FARO A, HIATT P, GILMARTIN G, HIGGINS M. Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation. J Cyst Fibros, 2014 Sep pii: S1569-1993(14)00216-1. doi: 10.1016/j.jcf.2014.09.005 (Epub adhad of print) NAEHRLICH L, BALLMANN M, DAVIES J, DERICHS N, GONSKA T, HJELTE L, VAN KONINGSBRUGGEN-RIETSCHEL S, LEAL T, MELOTTI P, MIDDLETON P, TÛMMLER B, VERMEULEN F, WILSCHANSKI M, ECFS Diagnostic Network Working Group. Nasal potential difference measurements in diagnosis of cystic fibrosis: an international survey. J Cyst Fibros, 2014 Jan;13(1):24-8. doi: 10.1016/j.jcf.2013.08.006. Epub 2013 Sep 7. BOON M, WALLMEIER J, MA L, LOGES NT, JASPERS M, OLBRICH H, DOUGHERTY GW, RAIDT J, WERNER C, AMIRAV I, HEVRONI A, ABITUL R, AVITAL A, SOFERMAN R, WESSELS M, O’CALLAGHAN C, CHUNG EM, RUTMAN A, HIRST RA, MOYA E, MITCHISON HM, VAN DAELE S, DE BOEK K, JORISSEN M, KINTNER C, CUPPENS H, OMRAN H. MCIDAS mutation result in a mucociliary clearance disorder with reduced generation of multiple motile cilia. Nat Commun, 2014 Jul;22(5):4418. Doi 10.1038/ncomms5418. FRANS G, MOENS L, SCHABALLIE H, VAN EYCK L, BORGERS H, WUYTS M, DILLAERTS D, VERMEULEN E, DOOLEY J, GRIMBACHER B, CANT A, DECLERCK D, PEUMANS M, RENARD M, DE BOECK K, HOFFMAN I, FRANCOIS I, LISTON A, CLAESSENS F, BOSSUYT X, METYS I. Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): Chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding. J Allergy Clin Immuno, 2014 Jul 18 doi: 10.1016/j.jaci.2014.05.044 [epub ahead of print) BELL SC, DE BOECK K, AMARAL MD. New pharmacological approaches for cystic fibrosis: Promises, progress, pitfalss. Pharmacol Ther, 2014 Jun 14 doi: 10.1016/j.pharmthera.2014.06.005

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[Epub ahead of print) BEEKMAN JM, SERMET-GAUDELUS I, DE BOECK K, GONSKA T, DERICHS N, MALL MA, MEHTA A, MARTIN U, DRUMM M, AMARAL MD. CFTR functional measurements in human models for diagnosis, prognosis and personalized therapy: Report of the pre-conference meeting to the 11th ECFS Basic Science Conference, Malta, 26-29 March 2014. J Cyst Fibros 2014 Jul;13(4):363-72. Doi: 10.1016/j.jcf.2014.05.007. Epub 2014 Jun 2 PROESMANS M, GIJSENS B, VAN DE WIJDEVEN P, DE CALUWE H, VERHAEGEN J, LAGROU K, VAN EVEN E, VERMEULEN F, DE BOECK K. Clincal outcome of parapneumonic empyema in children treated according to a standardized medical treatment. Eur J Pediatr 2014 May 17 [Epub ahead of print). KEREM E, KONSTAN MW, DE BOECK K, ACCURSO FJ, SERMET-GAUDELUS I, WILSCHANSKI M, ELBORN JS, MELOTI P, BRONSVELD I, FAJAC I, MALFROOT A, ROSEBLUTH DB, WALKER PA, McCOLLEY SA, KNOOP C, QUATTRUCCI S, RIETSCHEL E, ZEITLIN PL, BARTH J, ELFRING GL, WELCH EM, BRANSTORM A, SPIEGEL RJ, PELTZ SW, AJAYI T, ROWE SM, Cystic Fibrosis Ataluren Study Group. Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Respir Med. 2014 Jul;2(7):539-47. Doi: 10.1016/S2213-2600(14)70100-6. Epub 2014 May 15 BOON M, DE BOECK K, JORISSEN M, MEYTS I. Primary ciliary dyskinesia and humoral immunodeficiency – is there a missing link? Respir Med 2014 Jun;108(6):931-4. Doi: 10.1016/j.med.2014.03.009 Epub 2014 Apri 2. BOON M, MEYTS I, PROESMANS M, VERMEULEN FL, JORISSEN M, DE BOECK K. Diagnostic accuracy of nitric oxide measurements to detect primary ciliary dyskinesia. Eur J Clin Invest 2014 May;44(5):477-85. Doi: 10.1111/eci.12254 BOON M, SMITS A, CUPPENS H, JASPERS M, PROESMANS M, DUPONT LJ, VERMEULEN FL, VAN DAELE S, MALFROOT A, GODDING V, JORISSEN M, DE BOECK K. Primary ciliary dyskinesia: critical evaluation of clinical symptoms and diagnosis in patients with normal and abnormal ultrastructure. Orphanet J Rare Dis 2014 Jan 22;9(1):11. Doi 10.1186/1750-1172-9-11 DE BOECK K, ZOLIN A, CUPPENS H, OLESEN HV, VIVIANI l. The relative frequency of CFTR mutation classes in European patients with cystic fibrosis. J Cyst Fibros 2014 Jul;13(4):403-9. Doi: 10.1016/j.jcf.2013.12.003 Epub 2014 Jan 16 KENT L, REIX P, INNES JA, ZIELEN S, LE BOURGEOIS M, BRAGGION C, LEVER S, ARETS HG, BROWNLEE K, BRADLEY JM, BAYFIELD K, O’NEILL K, SAVI D, BILTON D, LINDBLAD A, DAVIES JC, SERMET I, DE BOECK K. European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN) Standardisation Committee Lung Clearance index: evidence for use in clinical trials in cystic fibrosis. J Cyst Fibros 2014 Mar;13(2):123-38 doi: 10.1016/j.jcf.2013.09.005. Epub 2013 Dec 5. THOMAS M, LEMONNIER L, GULMANS V, NAEHRLICH L, VERMEULEN F, CUPPENS H, CASTELLANI C, NOREK A, DE BOECK K. Is there evidence for correct diagnosis in cystic fibrosis registries? J Cyst Fibros 2014 May;13(3):275-80 doi: 10.1016/j.jcf.2013.10.010. Epub 2013 Nov 22 VERMEULEN F, PROESMANS M, BOON M, HAVERMANS T, DE BOECK K. Lung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis. Thorax 2014 Jan;69(1):39-45. Doi: 10.1136/thoraxjnl-2013-203807. Epub 2013 Sep 10 DE BOECK K FAJAC I RATJEN F. Endpoints and biomarkers for clinical trials in cystic fibrosis. In: European Respiratory Monographs 2014 Ed. M. Mall and S. Elborn Print ISBN:978-1-84984-050-7 DE BOECK K, MUNCK A, WALKER S, FARO A, HIATT P, GILMARTIN G, HIGGINGS M. Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation. J Cyst Fibros 2014 Sep26 pii: S1569-1993(14)00216-1 doi: 10.1016/j.jcf.2014.09.005. [Epub ahead of print] PEETERMANS M, GOEMINNE P, DE BOECK C, DUPONT LJ. IgE Sensitization to Aspergillus fumigatus is Not a Bystander Phenomenon in Cystic Fibrosis Lung Disease. Chest. 2014 Sep 1;146(3):e99-e100 TIDDENS HA, DE BOECK K, CLANCY JP, FAYON M, BRESNIK M, DERCHAK A, LEWIS SA, OEMANN CM; for the ALPINE study investigators. Open label study of inhaled aztreonam for Pseudomonas eradication in children with cystic fibrosis: the ALPINE study. J Cyst Fibros. 2014 Aug 1. pii: S1569-1993(14)00152-0. DE BOECK K, CASTELLANI C, ELBORN JS, ECFS Board. Medical consensus, guidelines, and position papers: A policy for the ECFS. J Cyst Fibros. 2014 Sep;13(5):495-8 2013 BOYLE MP, DE BOECK K. A new era in the treatment of cystic fibrosis: correction of the underlying

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CFTR defect. Lancet Respir Med 2013 Apr;1(2):101 DE BOECK K, TIDDENS H, ELBORN S, FAJAC I, European Cystic Fibrosis (ECFS) and the ECFS Clinical Trial Network. A new clinical trials directive to boost academic trials? Lancet Respir Med 2013 Apr;1(2):99-101. Doi: 10.1016/S2213-2600(13)70041-9. Epub 2013 Mar 21 DE BOECK K. Trying to find a cure for cystic fibrosis: CFTR biomarkers as outcomes. Eur Respir J 2013 Oct;42(4):1156-7. Doi:10.1183/09031936.00029913. DUYTSCHAEVER G, HUYS G, BOULANGER L, DE BOECK K, VANDAMME P. Amoxicillinclavulanic acid resistance in fecal Enterobacteriaceae from patients with cystic fibrosis and healthy siblings. J Cyst Fibros 2013 Dec;12(6):780-3. Doi. 10.1016/j.jcf.2013.06.006 Epub 2013 Jul 16 VERMEULEN F, OPHOFF J, PROESMANS M, DE BOECK K. Comparison of lung clearance index measured during helium washin and washout in children with cystic fibrosis. Pediatr Pulmonol 2013 Oct;48(10):962-9. Doi.10.1002/ppul.22719. Epub 2013 May 9 HAVERMANS T, COLPAERT K, DE BOECK K, DUPONT L, ABBOTT JJ. Pain in CF: review of the literature. J Cyst Fibros 2013 Sep;12(5):423-30. Doi. 10.1016/j.jcf.2013.04.001 BOON M, JORISSEN M, JASPERS M, CUPPENS H, DE BOECK K. Is the sensitivity of primary ciliary dyskinesia detection by ciliary function analysis 100%? Eur Respir J, 2013 Oct;42(4):1159-61. Doi:10.1183/09031936.00078713. PROESMANS M, VERMEULEN F, BOULANGER L, VERHAEGEN J, DE BOECK K. Comparison of two treatment regimens for eradication of Pseudomonas aeruginosa infection in children with cystic fibrosis. J Cyst Fibros 2013; 12: 29-34. BOON M, JORISSEN M, PROESMANS M, DE BOECK K. Primary ciliary dyskinesia, an orphan disease. Eur J Pediatr 2013; 172: 151-62. DE BOECK K, KENT L, DAVIES J, DERICHS N, AMARAL M, ROWE SM, MIDDLETON P, DE JONGHE H, BRONSVELD I, WILSCHANSKI M, MELOTTI P, DANNER-BOUCHER I, BOERNER S, FAJAC I, SOUTHERN K, DE NOOIJER RA, BOT A, DE RIJKE Y, DE WACHTER E, LEAL T, VERMEULEN F, HUG MJ, RAULT G, NGUYEN-KHOA T, BARRETO C, PROESMANS M, SERMETGAUDELUS I; EUROPEAN CYSTIC FYBROSIS SOCIETY CLINICAL TRIAL NETWORK STANDARDISATION COMMITTEE. CFTR biomarkers: time for promotion to surrogate end-point. Eur Respir J 2013; 41: 203-16. GOEMINNE PC, KICINSKI M, VERMEULEN F, FIERENS F, DE BOECK K, NEMERY B, NAWROT TS, DUPONT LJ. Impact of air pollution on cystic fibrosis pulmonary exacerbations: a case-crossover analysis. Chest 2013; 143: 946-54. BRONSVELD I, VERMEULEN F, SANDS D, LEAL T, LEONARD A, MELOTTI P, YAAKOV Y, DE NOOIJER R, DE BOECK K, SERMET I, WILSCHANSKI M, MIDDLETON PG; EUROPEAN CYSTIC FIBROSIS SOCIETY – DIAGNOSTIC NETWORK WORKING GROUP. Influence of perfusate temperature on nasal potential difference. Eur Respir J 2013; 42: 389-93. WITTERS P, DUPONT L, VERMEULEN F, PROESMANS M, CASSIMAN D, WALLEMACQ P, DE BOECK K. Lung transplantation in cystic fibrosis normalizes essential fatty acid profiles. J Cyst Fibros 2013; 12: 222-8. DUYTSCHAEVER G, HUYS G, BEKAERT M, BOULANGER L, DE BOECK K, VANDAMME P. Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota. J Cyst Fibros 2013; 12: 206-15. BILTON D, BELLON G, CHARLTON B, COOPER P, DE BOECK K, FLUME PA, FOX HG, GALLAGHER CG, GELLER DE, HAARMAN EG, HEBESTREIT HU, KOLBE J, LAPEY A, ROBINSON P, WU J, ZUCKERMAN JB, AITKEN ML, CF301 AD CF302 INVESTIGATORS. Pooled analysis of two large randomized phase III inhaled mannitol studies in cystic fibrosis. J Cyst Fibros 2013; 12: 367-76. SCHABALLIE H, RENARD M, VERMYLEN C, SCHEERS I, REVENCU N, REGAL L, CASSIMAN D, SEVENANTS L, HOFFMAN I, CORVELEYN A, BORDON V, HAERYNCK F, ALLEGAERT K, DE BOECK K, ROSKAMS T, BOECKX N, BOSSUYT X, MEYTS I. Misdiagnosis as asphyxiating thoracic dystrophy and CMV-associated haemophagocytic lymphohistiocytosis in Shwachman-diamond syndrome. Eur J Pediatr 2013; 172: 613-22. KENT L, REIX P, INNES JA, ZIELEN S, LE BOURGEOIS M, BRAGGION C, LEVER S, ARETS HG, BROWNLEE K, BRADLEY JM, BAYFIELD K, O’NEILL K, SAVI D, BILTON D, LINDBLAD A, DAVIES JC, SERMET I, DE BOECK K, ON BEHALF OF THE EUROPEAN CYSTIC FIBROSIS SOCIETY CLINICAL TRIAL NETWORK (ECFS-CTN) STANDARDISATION COMMITTEE. Lung Clearance Index: Evidence for use in clinical trials in cystic fibrosis. J Cyst Fibros 2013. Dec 4. pii: S15691993(13)00155-0. doi: 10.1016/j.jcf.2013.09.005. THOMAS M, LEMONNIER L, GULMANS V, NAEHRLICH L, VERMEULEN F, CUPPENS H,

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CASTELLANI C, NOREK A, DE BOECK K. Is there evidence for correct diagnosis in cystic fibrosis registries? J Cyst Fibros 2013. Nov 22. pii: S1569-1993(13)00167-7. doi: 10.1016/j.jcf.2013.10.010 2012 LOUW JJ, TOELEN J, PROESMANS M, VERMEULEN F, BILLEN J, DE BOECK K. Serum procalcitonin is not an early marker of pulmonary exacerbation in children with cystic fibrosis. Eur J Pediatr 2012;171:139-42. PROESMANS M, BOON M, VERBEKEN E, OZCELIK U, KIPER N, VAN DE CASSEYE W, DE BOECK K. Pulmonary alveolar microlithiasis: a case report and review of the literature. Eur J Pediatr. 2012; 171:1069-72 CLANCY JP, ROWE SM, ACCURSO FJ, AITKEN ML, AMIN RS, ASHLOCK MA, BALLMANN M, BOYLE MP, BRONSVELD I, CAMPBELL PW, DE BOECK K, DONALDSON SH, DORKIN HL, DUNITZ JM, DURIE PR, JAIN M, LEONARD A, MCCOY KS, MOSS RB, PILEWSKI JM, ROSENBLUTH DB, RUBENSTEIN RC, SCHECHTER MS, BOTFIELD M, ORDOÑEZ CL, SPENCER-GREEN GT, VERNILLET L, WISSEH S, YEN K, KONSTAN MW. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax 2012;67:12-8. BOON M, PROESMANS M, DE BOECK K. Hemoptysis after orthopedic surgery in an adolescent boy. Pediatr Pulmonol 2012;47:623-5. AITKEN ML, BELLON G, DE BOECK K, FLUME PA, FOX HG, GELLER DE, HAARMAN EG, HEBESTREIT HU, LAPEY A, SCHOU IM, ZUCKERMAN JB, CHARLTON B; CF302 INVESTIGATORS. Long-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study. Am J Respir Crit Care Med 2012; 185:645-52. D’ALQUEN D, DE BOECK K, BRADLEY J, VÁVROVÁ V, DEMBSKI B, WAGNER TO, PFALZ A, HEBESTREIT H. Quality assessment of expert answers to lay questions about cystic fibrosis from various language zones in Europe: the ECORN-CF project. BMC Med Res Methodol 2012; 12:11. BROWN SC, DE LAAT M, PROESMANS M, DE BOECK K, VAN RAEMDONCK D, LOUW J, HEYING R, COOLS B, EYSKENS B, GEWILLIG M. Treatment strategies for pulmonary sequestration in childhood: resection, embolization, observation? Acta Cardiol 2012; 67:629-34. DE BOECK K. Has the hospital become the place not to be for infants with bronchiolitis? Eur J Pediatr 2012; 171:1723-4. BORGERS H, MEYTS I, DE BOECK K, RAES M, SAUER K, PROESMANS M, MOENS L, JEURISSEN A, FLAMAING J, PEETERMANS WE, VERHAEGEN J, BOSSUYT X. Fold-increase in antibody titer upon vaccination with pneumococcal unconjugated polysaccharide vaccine. Clin Immunol 2012; 145:136-8. VERHULST S, DE BOECK K. Respiratory problems in children with Down syndrome. Tijdschrift van de Belgische kinderarts 2012; 14:29-31. DE BOECK K. Pentalfa: Hoop op een nieuwe toekomst in de behandeling van CF-longlijden. Nieuwe aanpak in de correctie van de “cystic fibrosis transmembrane regulator”(CFTR)-functie. Tijdschr Geneesk 2012; 68:298-301 DÖRING G, FLUME P, HEIJERMAN H, ELBORN JS; CONSENSUS STUDY GROUP Treatment of lung infection in patients with cystic fibrosis: current and future strategies. J Cyst Fibros. 2012 Dec;11(6):461-79. 2011 HAVERMANS T, WUYTACK L, DEBOEL J, TIJTGAT A, MALFROOT A, DE BOECK K, PROESMANS M. Siblings of children with cystic fibrosis: quality of life and the impact of illness. Child Care Health Dev 2011; 37:252-60. VERMEULEN F, PROESMANS M, FEYAERTS N, DE BOECK K. Nasal potential measurements on the nasal floor and under the inferior turbinate: does it matter? Pediatr Pulmonol. 2011;46:145-52. DE BOECK K, DERICHS N, FAJAC I, DE JONGE HR, BRONSVELD I, SERMET I, VERMEULEN F, SHEPPARD DN, CUPPENS H, HUG M, MELOTTI P, MIDDLETON PG, WILSCHANSKI M ON BEHALF OF THE ECFS DIAGNOSTIC NETWORK WORKING GROUP AND THE EUROCARECF WP3 GROUP ON CF DIAGNOSIS. New clinical diagnostic procedures for CF in Europe. J Cyst Fibros 2011;10: S53-66. DE BOECK K, BULTEEL V, TIDDENS H, WAGNER T, FAJAC I, CONWAY S, DUFOUR F, SMYTH A, LEE T, SERMET I, KASSAI-KOUPAI B, ELBORN S ON BEHALF OF ALL ECFS-CTN NETWORK PARTNERS. Guideline on the design and conduct of CF clinical trials: the ECFS Clinical Trial Network (ECFS-CTN). J Cyst Fibros 2011; 10: S67-74. BILTON D, CANNY G, CONWAY S, DUMCIUS S, HJELTE L, PROESMANS M, TÜMMLER B,

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VAVROVA V, DE BOECK K. Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials. J Cyst Fibros 2011; 10:S79-S81. BOMBIERI C, CLAUSTRES M, DE BOECK K, DERICHS N, DODGE J, GIRODON E, SERMET I, SCHWARZ M, TZETIS M, WILSCHANSKI M, BAREIL C, BILTON D, CASTELLANI C, CUPPENS H, CUTTING GR, DREVINEK P, DURIE P, FARRELL P, GONSKA T, ELBORN JS, JARVI K, KEREM B, KEREM E, KNOWLES M, MACEK M JR, MUNCK A, RADOJKOVIC D, SEIA M, SHEPPARD DN, SOUTHERN K, STUHRMANN M, TULLIS E, ZIELENSKI J, PIGNATTI PF, FEREC C. Recommendations for the classification of diseases as CFTR-related disorders. J Cyst Fibros 2011;10: S86-102. DE BOECK K, VERMEULEN F, MEYTS I, HUTSEBAUT L, FRANCKAERT D, PROESMANS M. Coprescription of antibiotics and asthma drugs in children. Pediatrics 2011; 127:1022-6. DE BOECK K, VERMEULEN F, WANYAMA S, THOMAS M. Inhaled corticosteroids and lower lung function decline in young children with cystic fibrosis. Eur Respir J 2011; 37: 1091-5. DE BOECK K, ASHLOCK M. Introduction to Section I: The relevance of CF diagnostic tools for measuring restoration of CFTR function after therapeutic interventions in human clinical trials. Methods Mol Biol 2011;741:3-11 PROESMANS M, ELS C, VERMEULEN F, DE BOECK K. Change in IgG and evolution of lung function in children with cystic fibrosis. J Cyst Fibros 2011; 10:128-31. HAVERMANS T, ABBOTT J, COLPAERT K, DE BOECK K. Communication and information about reproductive and sexual health in cystic fibrosis. Patients, parents and caregivers’ experience. J Cyst Fibros 2011;10:221-7. BILTON D, CANNY G, CONWAY S, DUMCIUS S, HJELTE L, PROESMANS M, TÜMMLER B, VAVROVA V, DE BOECK K. Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials. J Cyst Fibros 2011; S79-81. DUYTSCHAEVER G, HUYS G, BEKAERT M, BOULANGER L, DE BOECK K, VANDAMME P. Cross-sectional and longitudinal comparisons of the predominant fecal microbiota compositions of a group of pediatric patients with cystic fibrosis and their healthy siblings. Appl Environ Microbiol 2011;77:8015-24. WITTERS P, LIBBRECHT L, ROSKAMS T, DE BOECK K, DUPONT L, PROESMANS M, VERMEULEN F, STRANDVIK B, LINDBLAD A, STÉPHENNE X, SOKAL E, GOSSEYE S, HEYE S, MALEUX G, AERTS R, MONBALIU D, PIRENNE J, HOFFMAN I, NEVENS F, CASSIMAN D. Noncirrhotic presinusoidal portal hypertension is common in cystic fibrosis-associated liver disease. Hepatology 2011; 53:1064-5. BULTEEL V, CASTELLANI C, CONWAY SP, DUBOIS C, FAJAC I, PEREIRA L, REIMANN ALG, DE BOECK K. Developing an international network for clinical research: the European Cystic Fibrosis Society – Clinical Trials Network experience. Clin Invest 2011;1:775-80. DE BOECK K, REYBROUCK T. Editorial from Guest Editors: Children with Congenital Heart Disease. Current Respiratory Medicine Reviews 2011;7:72. DE BOECK K, CUPPENS H. Ion channel regulators for the treatment of cystic fibrosis. Therapy 2011; 8: 661-670. MOSHOUS D, MEYTS I, FRAITAG S, JANSSEN CE, DEBRÉ M, SUAREZ F, TOELEN J, DE BOECK K, ROSKAMS T, DESCHILDRE A, PICARD C, BODEMER C, WOUTERS C, FISCHER A Granulomatous inflammation in cartilage-hair hypoplasia: risks and benefits of anti-TNF-α mAbs. J Allergy Clin Immunol 2011; 128:847-53 VIVIANI L, ASSAEL BM, KEREM E; ECFS (A) H1N1 STUDY GROUP. Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis. J Cyst Fibros 2011 Sep;10(5):370-6. 2010 SMYTH AR, BARBATO A, BEYDON N, BISGAARD H, DE BOECK K, BRAND P, BUSH A, FAUROUX B, DE JONGSTE J, KORPPI M, O’CALLAGHAN C, PIJNENBURG M, RATJEN F, SOUTHERN K, SPENCER D, THOMSON A, VYAS H, WARRIS A, MERKUS PJ. Respiratory medicines for children: current evidence, unlicensed use and research priorities. Eur Respir J. 2010;35:247-65. BORGERS H, MOENS L, PICARD C, JEURISSEN A, RAES M, SAUER K, PROESMANS M, DE BOECK K, CASANOVA JL, MEYTS I, BOSSUYT X. Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assay. Clin

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Immunol. 2010;134:198-205. HIRCHE TO, BRADLEY J, D’ALQUEN D, DE BOECK K, DEMBSKI B, ELBORN JS, GLEIBER W, LAIS C, MALFROOT A, WAGNER TO, EUROPEAN CENTRES OF REFERENCE NETWORK FOR CYSTIC FIBROSIS (ECORN-CF) STUDY GROUP. Travelling with cystic fibrosis: recommendations for patients and care team members. J Cyst Fibros. 2010; 9:385-99. BOON M, MEYTS I, WARNIER G, DE BOECK K. Exhaled Nitric Oxide: Offline Tidal Breathing Measurements Are Feasible in Children and Correlate with Online Single Breath Measurements. Pediatric Allergy Immunol Pulmonol 2010; 23:201-6. PROESMANS M, VERMEULEN F, VREYS M, DE BOECK K. Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis. Int J of Pediatr 2010:376287. DECRAENE A, WILLEMS-WIDYASTUTI A, KASRAN A, DE BOECK K, BULLENS DM, DUPONT LJ. Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients. Respir Res 2010; 11:177. 2009 VAN ACKERE T, PROESMANS M, VERMEULEN F, VAN RAEMDONCK D, DE BOECK K. Complicated parapneumonic effusion in Belgian children: increased occurrence before routine pneumococcal vaccine implementation. Eur J Pediatrics 2009;168:51-8. GOUBAU C, WILSCHANSKI M, SKALICKÁ V, LEBECQUE P, SOUTHERN K, SERMET I, MUNCK A, DERICHS N, MIDDLETON PG, HJELTE L, PADOAN R, VASAR M, DE BOECK K. Phenotypic characterization of patients with intermediate sweat chloride values: towards validation of the European diagnostic algorithm for cystic fibrosis. Thorax 2009; 64:683-91. AZAD AK, RAUH R, VERMEULEN F, JASPERS M, KORBMACHER J, BOISSIER B, BASSINET L, FICHOU Y, GEORGES MD, STANKE F, DE BOECK K, DUPONT L, BALAŠČÁKOVÁ M, HJELTE L, LEBECQUE P, RADOJKOVIC D, CASTELLANI C, SCHWARTZ M, STUHRMANN M, SCHWARZ M, SKALICKA V, DE MONESTROL I, GIRODON E, FÉREC C, CLAUSTRES M, TÜMMLER B, CASSIMAN JJ, KORBMACHER C, CUPPENS H. Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease. Hum Mutat 2009; 30:1093-103. PROESMANS M, DE BOECK K. Clinical practice: treatment of childhood empyema. Eur J Pediatr 2009; 168:639-45. PROESMANS M, HEYNS L, MOONS P, HAVERMANS T, DE BOECK K. Real life evaluation of intravenous antibiotic treatment in a paediatric cystic fibrosis centre: outcome of home therapy is not inferior. Respir Med 2009;103:244-50 LEBECQUE P, LEONARD A, DE BOECK K, DE BAETS F, MALFROOT A, CASIMIR G, DESAGER K, GODDING V, LEAL T. Early referral to cystic fibrosis specialist centre impacts on respiratory outcome. J Cyst Fibros 2009; 8:26-30 DE BOECK K, MOENS M, VAN DER AA N, MEERSMAN A, SCHUDDINCK L, PROESMANS M. ‘Difficult asthma’: can symptoms be controlled in a structured environment? Pediatr Pulmonol 2009; 44:743-8. PROESMANS M, SAUER K, GOVAERE E, RAES M, DE BILDERLING G, DE BOECK K. Montelukast does not prevent reactive airway disease in Young children hospitalized for RSV bronchiolitis. Acta Peadiatr 2009; 98:1830-4. WITTERS P, DE BOECK K, DUPONT L, PROESMANS M, VERMEULEN F, SERVAES R, VERSLYPE C, LALEMAN W, NEVENS F, HOFFMAN I, CASSIMAN D. Non-invasive liver elastography (Fibroscan) for detection of cystic fibrosis-associated liver disease. J Cyst Fibros. 2009; 8:392-9. HEIJERMAN H, WESTERMAN E, CONWAY S, TOUW D, DÖRING G; CONSENSUS WORKING GROUP. Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus. J. Cyst. Fibros. 2009;8(5):295-315 SERMET-GAUDELUS I, CASTANET M, SOUBERBIELLE JC, MALLET E; LE GROUPE DE TRAVAIL SUR MINÉRALISATION OSSEUSE ET MUCOVISCIDOSE DE LA FÉDÉRATION FRANCAISE DES CENTRES DE RESSOURCE ET DE COMPÉTENCE EN MUCOVISCIDOSE. Bone health in cystic fibrosis. Arch Pediatr. 2009 ;16(6) :616-8 MAYELL SJ, MUNCK A, CRAIG JV, SERMET I, BROWNLEE KG, SCHWARZ MJ, CASTELLANI C, SOUTHERN KW; EUROPEAN CYSTIC FIBROSIS SOCIETY NEONATAL SCREENING WORKING GROUP. A European consensus for the evaluation and management of infants with an equivocal diagnosis following newborn screening for cystic fibrosis. J Cyst Fibros 2009;8:71-8 O’BYRNE PM, PEDERSEN S, LAMM CJ, TAN WC, BUSSE WW ; START INVESTIGATORS

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GROUP. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med. 2009;179(1):19-24. 2008 DE BOECK K, VERMEULEN F, PROESMANS M Lipid laden macrophage index and gastroesophageal reflux-related respiratory disease in children. Pediatrics 2008; 122:680-1. MATHEI J, COOSEMANS W, NAFTEUX P, DECKER G, DE LEYN P, VAN RAEMDONCK D, HOFFMAN I, DE BOECK C, PROESMANS M, LERUT T Laparoscopic Nissen fundoplication in infants and children: analysis of 106 consecutive patients with special emphasis in neurologically impaired vs. neurologically normal patients. Surg Endosc 2008; 22:1054-9. MOENS L, WUYTS M, MEYTS I, DE BOECK K, BOSSUYT X; Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response. J Immunol 2008; 181:5306-12. DE BOECK K, VERMEULEN F, VREYS M, MOENS M, PROESMANS M. Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence? Eur J Pediatr 2008; 167:607-12. PROESMANS M, VERMEULEN F, DE BOECK K What's new in cystic fibrosis? From treating symptoms to correction of the basic defect. Eur J Pediatr 2008; 167: 839-49. SCHELSTRAETE P, VAN DAELE S, DE BOECK K, PROESMANS M, LEBECQUE P, LECLERCQFOUCART J, MALFROOT A, VANEECHOUTTE M, DE BAETS F. Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients. Eur Resp J 2008; 31:822-9. MEYTS I DE BOECK K PROESMANS M VERMEULEN F Subcutane immuunglobuline therapie: overzicht en toepassing in de kindergeneeskunde. De Agenda Pediatrie Januari 2008 BULLENS D, DECRAENE A, DILISSEN E, MEYTS I, DE BOECK K, DUPONT L, CEUPPENS J. Type III interferon-|*lambda*| mRNA expression in sputum of adult and school-aged asthmatics. Clinical and Experimental Allergy 2008; 38:1459-67. BUSSE WW, PEDERSEN S, PAUWELS RA, TAN WC, CHEN YZ, LAMM CJ, O'BYRNE PM; START INVESTIGATORS GROUP. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol. 2008 May;121(5):1167-74 2007 DE BOECK K, DE BAETS F, MALFROOT A, DESAGER K, MOUCHET F, PROESMANS M Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients? Eur J Pediatr 2007; 166:23-8. JEURISSEN A, MOENS L, RAES M, WUYTS G, WILLEBRORDS L, SAUER K, PROESMANS M, CEUPPENS JL, DE BOECK K, BOSSUYT X Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens. Clin Chem 2007; 53:505-10. VAN HOEYVELD E, ZHANG PX, DE BOECK K, FULEIHAN R, BOSSUYT X Hyper-immunoglobulin M syndrome caused by a mutation in the promotor for CD40L. Immunology 2007; 120:497-501. MOENS L, VERHAEGEN J, PIERIK M, VERMEIRE S, DE BOECK K, PEETERMANS WE, BOSSUYT X Toll-like receptor 2 and toll-like receptor 4 polymorphisms in invasive pneumococcal disease. Microbes Infect 2007; 9:15-20. BOSSUYT X, MOENS L, VAN HOEYVELD E, JEURISSEN A, BOGAERTS G, SAUER K, PROESMANS M, RAES M, DE BOECK K Coexistence of (partial) immune defects and risk of recurrent respiratory infections. Clin Chem 2007; 53:124-30. HAVERMANS T, DE BOECK K Cystic fibrosis: a balancing act? J Cystic Fibrosis 2007; 6:161-2. VERGISON A, DENIS O, DEPLANO A, CASIMIR G, CLAEYS G, DE BAETS F, DE BOECK K, DOUAT N, FRANCKX H, GIGI J, IEVEN M, KNOOP C, LEBECQUE P, LEBRUN F, MALFROOT A, PAUCQUAY F, PIERARD D, VAN ELDERE J, STRUELENS MJ National survey of molecular epidemiology of staphylococcus aureus colonization in Belgian cystic fibrosis patients. J Antimicrob Chemother 2007; 59:893-9. 2006 DE BOECK K, WILSCHANSKI M, CASTELLANI C, TAYLOR C, CUPPENS H, DODGE J, SINAASAPPEL M. Cystic Fibrosis: terminology and diagnostic algorithms. Thorax 2006;61:627-35 (Epub 2005 Dec 29, 2005) (impact factor 5.040) DE BOECK K, DE BAETS F, MALFROOT A, DESAGER K, MOUCHET F, PROESMANS M Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients? Eur J Pediatr 2006; Epub 2006 Jun24)

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PROESMANS M, BALINSKA-MISKIEWICZ W, DUPONT L, BOSSUYT X, VERHAEGEN J, HOIBY N, DE BOECK K Evaluating the ‘Leeds’ criteria for Pseudomonas aeruginosa infection in a cystic fibrosis centre. Eur Resp J 2006; 27:937-43. HAVERMANS T, VREYS M, PROESMANS M, DE BOECK K. Assessment of agreement between parents and children of health-related quality of life in children with cystic fibrosis. Child: care, health and development 2006; 32:1-7. MOENS L, VANHOEYVELD E, VERHAEGEN J, DE BOECK K, PEETERMANS WE, BOSSUYT X. Fcgamma-receptor IIA genotype and invasive pneumococcal infection. Clin Immunol 2006; 118:20-3. POHUNEK P, KUNA P, JORUP C, DE BOECK K Budesonide/formoterol improves lung function compared with budesonide alone in children with asthma. Pediatr Allergy Immunol 2006; 17:458-65. VAN DAELE S, VANEECHOUTTE M, DE BOECK K, KNOOP C, MALFROOT A, LEBECQUE P, LECLERCQ-FOUCART J, VAN SCHIL L, DESAGER K, DE BAETS F Survey of Pseudomonas aeruginosa genotypes in Belgian colonized cystic fibrosis patients. Eur Resp J 2006; 28:740-7. VAN MIEGHEM T, LEWI L, VAN SCHOUBROECK D, OEPKES D, DE BOECK K, DEVLIEGER R. Prenatal therapy for primary fetal hydrothorax in a dichorionic twin pregnancy. Prenatal diagnosis 2006; 26:584-6. MOENS L, VAN HOEYVELD T, PEETERMANS WE, DE BOECK K, VERHAEGEN J, BOSSUYT X Mannose binding lectin genotype and invasive pneumococcal infection. Human Immunology 2006;67:605-11. SANDERS NN, FRANCK H, DE BOECK K, HAUSTRAETE J, DE SMEDT SC, DEMEESTER J Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis. Thorax 2006; 61:962-8. MEYTS I, HELLINGS PW, HENS G, VANAUDENAERDE BM, VERBINNEN B, HEREMANS H, MATTHYS P, BULLENS DM, OVERBERGH L, MATHIEU C, DE BOECK K, CEUPPENS JL IL-12 contributes to allergen-induced airway inflammation in experimental asthma. J Immunol 2006 177;6460-70. FLEMING DM, CROVARI P, WAHN U, KLEMOLA T, SCHLESINGER Y, LANGUSSIS A, OYMAR K, GARCIA ML, KRYGIER A, COSTA H, HEINIGER U, PREGALDIEN JL, CHENG SM, SKINNER J, RAZMPOUR A, SAVILLE M, GRUBER WC, FORREST B; CAIV-T ASTHMA STUDY GROUP. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J. 2006;25(10):860-9. MOENS L, VAN HOEYVELD E, PEETERMANS WE, DE BOECK K, VERHAEGEN J, BOSSUYT X. Mannose-binding lectin genotype and invasive pneumococcal infection. Hum Immunol. 2006; 67:60511. O’BYRNE PM, PEDERSEN S, BUSSE WW, TAN WC, CHEN YZ, OHLSSON SV, ULLMAN A, LAMM CJ, PAUWELS RA; START INVESTIGATORS GROUP. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest 2006; 129:1478-85. 2005 VAN HOVE J, JAEKEN J, PROESMANS M, DE BOECK K, MINNER K, MATTHIJS G, VERBEKEN E, DEMUNTER A, BOOGAERTS M. Clericuzio Type Poikiloderma With Neutropenia Is Distinct From Rothmund – Thomson Syndrome. American Journal of Medical Genetics 2005; 132A: 152-158 DE BOECK K, PROESMANS M, MORTELMANS L, VAN BILLOEN B, WILLEMS T, JORISSEN M. Mucociliary transport using 99mTc-albumin colloid: a reliable screening test for primary ciliary dyskinesia. Thorax 2005;60: 414-7 DE BOECK K, WEREN M, PROESMANS M, KEREM E. Pancreatitis in CF patients: correlation with pancreatic status and genotype. Pediatrics 2005; 115: e463-9 VANKEERBERGHEN A, SCUDIERO O, DE BOECK K, MACEK M jr, FRANCO PIGNATTI P, VAN HUL N, NUYTTEN H, SALVATORE F, CASTALDO G, ZEMKOVA D, VAVROVA V, CASSIMAN JJ, CUPPENS H. Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis patients. Genomics 2005; 85: 574-81 BOSSUYT X, MARIEN G, MEYTS I, PROESMANS M, DE BOECK K. Determination of IgG subclasses: a need for standardization. J Allergy Clin Immunol 2005; 115: 872-4 YARDEN J, RADOJKOVIC D, DE BOECK K, MACEK M Jr, ZEMKOVA D, VAVROVA V, VLETINCK R, CASSIMAN JJ, CUPPENS H. Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype. Thorax 2005; 60: 320-5 VANLAERE E, COENYE T, SAMYN E, VAN DEN PLAS C, GOVAN J, DEBAETS F, DE BOECK K, KNOOP C, VANDAMME P. a novel strategy for the isolation and identification of environmental Burkholderia capacia complex bacteria. FEMS Microbiology Letters 2005; 249:303-7.

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GOVAERE E, VAN RAEMDONCK D, DEVLIEGER H, SMET M, VERBEKEN E, PROESMANS M, DE BOECK K. Massive lung collapse with partial resolution after several years: a case report. BMC Pediatrics 2005;5:39 PAPAGIANNOPOULOS K, VAN RAEMDONCK D, DE BOECK K, LERUT T. Lymphangiomatosis Possibly With Gorham’s Disease and Not Lymphangioma Reply. Ann Thorac Surg 2005; 79: 1100 VAN DEN BRUEL A, AERTGEERTS B, DE BOECK K, BUNTINX F Measuring the body temperature: How accurate is the Tempa Dot ? Technology and Health Care 2005; 13: 97-106 Ed: BODART E, DAB I, DE BOECK K, MOSSAY C, RAES M. Astma en het kind. Gids voor de clinicus. 2004 DE BOECK K, MALFROOT A, VAN SCHIL L, LEBECQUE P, KNOOP C, GOVAN JRW, DOHERTY C, LAEVENS S, VANDAMME P. Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients. Eur Resp J 2004;23: 851-6 DECAESTECKER K, DECAESTECKER E, CASTELLANI C, JASPERS M, CUPPENS H, DE BOECK K. Genotype/phenotype correlation of the G85E mutation in a large cohort of cystic fibrosis patients. Eur Resp J 2004; 23: 679-84 YARDEN J, RADOJKOVIC D, DE BOECK K, MACEK M JR, ZEMKOVA D, VAVROVA V, VLIETINCK R, CASSIMAN JJ, CUPPENS H. Polymorphisms in the mannose binding lectin gene affect the cystic fibrosis pulmonary phenotype. J Med Genet. 2004;41:629-33 PAPAGIANOPOULOS K, VAN RAEMDONCK D, DE BOECK K, LERUT T. Pediatric thoracic lymphangiomatosis: is chest wall resection too radical? Ann Thorac Surg 2004; 77:695-7 DE BOECK K, BODART E, DEBAETS F, DEBILDERING G, DESAGER K, FRANCKX H, HELLINCKX J, LECLERCQ-FOUCART J, MALFROOT A, MOSSAY C, PIERART F, PROESMANS M, RAES M, VANDAELE S. Montelukast voor de behandeling van kinderen met astma. Tijdschr Geneesk 2004; 60: 745-51 DE JONG B, VANDER POORTEN V, SMET M, HERMANS R, PROESMANS M, DE BOECK K. A 1year old girl with fever and a unilateral swelling of the jaw. Eur J Pediatr 2004; 163: 179-80 MEYTS I, DE BOECK K. X-linked lymphoproliferative disease. Tijdschrift van de Belgische kinderarts 2004;6:67-69 2003 JEURISSEN A, BOUDEWIJNS M, PROESMANS M, CEUPPENS J.L., DE BOECK K, BOSSUYT X. Evaluation of the immune response to pneumococcal capsular polysaccharides. Acta Clinica Belgica 2003; 58: 106-110 MEYTS I, WEEMAES C.R., DE WOLF-PEETERS C, RENARD M, UYTTEBROECK A, DE BOECK K. Unusual and severe disease course in a child with ataxia-telangiectasia. Ped All Immunol. 2003; 14:330-3. MEYTS I, PROESMANS M, VAN GERVEN L, HOPPENBROUWERS K, DE BOECK K. Tidal off-line exhaled nitric oxide measurements in a pre-school population. Eur J Pediatr 2003; 162:506-10 MEYTS I, PROESMANS M, DE BOECK K. ENO corresponds with office evaluation of asthma control. Pediatr Pulmonol 2003; 36: 283-289. PROESMANS M., DE BOECK, K. Stridor bij het kind. Tijdschrift van de Belgische kinderarts 2003; 5(1): 41-46 MEYTS I, RAES M, PROESMANS M, DE BOECK K. Niet al wie piept, heeft asthma: trechtervormige trachea en tracheale bronchus bij een 11-jarige. Tijdschrift van de Belgische kinderarts 2003; 5: 57-58 BUSH A, WALLIS C, LEBECQUE P , DE BOECK K . Mutations of CFTR gene and intermediate sweat chloride levels. Am J Respir Crit Care Med 2003 Jun 1;167:1577-8 PROESMANS M, DE BOECK K. Omeprazole, a proton pump inhibitor improves residual steatorrhoea in cystic fibrosis in cystic fibrosis patients treated with high dose pancreatic enzymes. Eur J Pediatr 2003; 162: 760-763. DE BOECK K. Budesonide in the treatment of paediatric asthma. Clinical Opinions in Paediatric Asthma 2003; 1: 12-15. DE BOECK K, PROESMANS M, CUPPENS H. Nieuwe therapeutische strategieën bij mucoviscidose. Bloedvaten, Hart, Longen 2003; 8: 223-228. DE BOECK K, PROESMANS M, CUPPENS H. Nouvelles stratégies thérapeutiques dans la mucoviscidose. Vaisseaux, Cœur, Poumons 2003 ; 223-228.

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GOVAERE E, WELLENS W, VANDERWEGEN J, PROESMANS M, DE BOECK K. Zeldzame oorzaken van stridor en heesheid bij de zuigeling. Tijdschrift van de Belgische kinderarts 2003; 5(1): 47-49 PROESMANS M, MEYTS I, WOESTYN S, DE BOECK K. Twins with umbilical piercing, persistent fever and adenopathies. Tijdschrift van de Belgische kinderarts 2003; 5(4): 303-5 L SEVENANTS, S VANDAELE, M PROESMANS, F DEBAETS, D VANRAEMDONCK, K DE BOECK. Een kleuter met alveolaire proteinose. Tijdschrift van de Belgische kinderarts 2003; 5(4): 306-9 DE BOECK K, PROESMANS M, CUPPENS H. Nieuwe therapeutische strategieën bij mucoviscidose. Percentiel 2003; 8: 149-153. PAUWELS RA, PEDERSEN S, BUSSE WW, TAN WC, CHEN YZ, OHLSSON SV, ULLMAN A, LAMM CJ, O’BYRNE PM; START INVESTIGATORS GROUP. Lancet. 2003;361(9363):1071-6. 2002 LEBECQUE P, LEAL T, DE BOECK C, JASPERS M, CUPPENS H, CASSIMAN JJ Mutations of the cystic fibrosis gene and intermediate sweat chloride levels. Am J Resp Crit Care Med 2002, 165: 75761 MEYTS I, WUYTS W, PROESMANS M, DE BOECK K. Variability of fecal pancreatic elastase measurements in cystic fibrosis patients. Journal of Cystic Fibrosis 2002; 1: 265-68 PROESMANS M, DE BOECK K. Evaluation of dietary fiber intake in belgian children with cystic fibrosis: is there a link with gastrointestinal complaints ? J Pediatr Gastroenterol Nutr. 2002; 35: 610-4 BREYSEM L, LOYEN S, BOETS A, PROESMANS M, DE BOECK K, SMET MH. Pediatric emergencies: thoracic emergencies. Eur Radiol 2002; 12 : 2849-65 TAL A, SIMON G, VERMEULEN JH, PETRU V, COBOS N, EVERARD ML, DE BOECK K. Budesonide/formoterol in a single inhaler versus inhaled corticosteroids alone in the treatment of asthma. Pediatr Pulmonol 2002; 34: 342-50 MEYTS I, VAN REEMPTS P, DE BOECK K. Monitoring of haemoglobin oxygen saturation in healthy infants using a new generation pulse oximeter which takes motion artifacts into account. Eur J Pediatr 2002; 161: 653-55 SEVENANTS L, DE BOECK C. Hoest en hoestremmers bij kinderen. Tijdschr. voor Geneeskunde 2002; 58: 762-68 MALFROOT A, BODART E, BARAN D, DE BAETS F, DE BILDERING G, DE BOECK K, DESAGER K, FRANCKX H, HELLINCKX J, LECLERCQ-FOUCART J, MOSSAY C, PIERART F, PROESMANS M, RAES M, VAN BEVER H, VANDAELE S. Montelukast bij kinderen met astma. Stand van zaken. Verslag van de rondetafelconferentie van 20 november 2001. Bijlage bij Tijdschrift van de Belgische Kinderarts 2002; 4(3) 2001 HELLINCKX J, CAUBERGHS M, DE BOECK K, DEMEDTS M. Evaluation of impulse oscillation system: comparison with forced oscillation technique and body plethysmography. Eur Respir J 2001; 18: 1-7 THOMEER M, DEMEDTS K, VANDEURZEN K and the VRGT Working Group on Interstitial Lung Diseases. Registration of interstitial lung diseases by 20 centers of respiratory medecine in Flanders. Acta Clinica Belgica 2001; 56: 163-72 AMARAL MD, PACHECO P, BECK S, FARINHA CM, PENQUE D, NOGUEIRA P, BARRETO C, LOPES B, CASALS T, DAPENA J, GARTNER S, VASQUEZ C, PEREZ-FRIAS J, OLVEIRA C, CABANAS R, ESTIVILL X, TZETIS M, KANAVAKIS E, DOUDOUNAKIS S, DORK T, TUMMLER B, GIRODON-BOULANDET E, CAZENEUVE C, GOOSSENS M, BLAYAU M, VERLINGUE C, VIEIRA I, FEREC C, CLAUSTRES M, DES GEORGES M, CLAVEL C, BIREMBAUT P, HUBERT D, BIENVENU T, ADOUN M, CHOMEL JC, DE BOECK K, CUPPENS H, LAVINHA J. Cystic fibrosis patients with the 3272-26A>G splicing mutation have milder disease than F508del homozygotes: a large European study. J Med Genet. 2001; 38: 777-83. VAN VALCKENBORGH I, WELLENS W, DE BOECK K, SNOECK R, DE CLERCQ E, FEENSTRA L. Systemic cidofovir in papillomatosis. Clin Inf Dis 2001; 32: e62-64 VAN RAEMDONCK D, DE BOECK K, DEVLIEGER H, DEMEDTS M, MOERMAN P, COOSEMANS W, DENEFFE G, LERUT T. Pulmonary sequestration: a comparison between adult and pediatric patients. Eur J Cardiothorac Surg 2001; 19: 388-95 VANDENBERGHE K, CASTEELS I, VANDENBUSSCHE E, DE ZEGER F, DE BOECK K. Bilateral cataract and high myopia in a child with trichothiodystrophy: a case report. Bull Soc Belge Ophtalmol.

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2001; 282: 15-8 PROESMANS M DE BOECK K De epidemiologie van astma bij het jonge kind. Tijdschr Geneesk 2001; 57: 91-95 DE BOECK K PROESMANS M Astma therapieconsensus. Tijdschr Geneesk 2001; 57: 96- 101 WARNIER G, PROESMANS M DE BOECK K Inhalatietherapie bij kinderen. Tijdschr Geneesk 2001; 57: 102-105 MOONEN R, AVENANT T, DE BOECK K. Acute bacteriele thyreoiditis bij een 8 weken oude zuigeling. Tijdschr voor Geneesk 2001; 57: 525-7 VAN RAEMDONCK D, VERLEDEN G, DELCROIX M, COOSEMANS W, DE LEYN P, VAN HAECKE J, DE BOECK K, DAENEN W, LAUWERS P, VANDERMEERSCH E, DEMEDTS M, LERUT T. Honderd long en hart-long transplantaties in de uriversitaire ziekenhuizen K.U.Leuven. Tijdschr voor Geneesk 2001; 57: 609-16. DE BOECK K Hersenvliesontsteking in opmars. Straal 7-11-2001 2000 DE BOECK K, ALIFIER M, VANDEPUTTE S. Sputum induction in young cystic fibrosis patients. Eur Resp J 2000, 16: 91-94 DE BOECK K. Improving standards of clinical care in cystic fibrosis. Eur Resp J 2000; 16: 585-87 PROESMANS M, DE BOECK K. Failure of local defense mechanisms in cystic fibrosis. Acta Otorhinolaryngol Belg 2000, 54: 367-72 AVENANT T, DE BOECK K. A painful neck mass in a five-year-old boy. Pediatric Inf Dis J 2000, 19: 903-5 JORISSEN M, WILLEMS T, DE BOECK K. Diagnostic evaluation of mucociliary transport: from symptoms to coordinated ciliary activity after ciliogenesis in culture. Am J Rhinol 2000; 14:345-52. JORISSEN M, WILLEMS T, VANDERSCHUEREN B, VERBEKEN E, DE BOECK K. Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture. Acta Otolaryngologica Belg 2000; 54: 343-56 K DE BOECK. Mucoviscidose, een nieuwe kijk op een oude ziekte. Tijdschr voor Geneesk 2000; 56: 85-93 K DE BOECK, VERBRUGGHE W Inhalatiecorticoiden bij kinderen met astma: doeltreffend en veilig? Tijdschr voor Geneesk 2000; 56: 1608-1616 MEYTS I, PROESMANS M, DE BOECK K. Tuberculeuze meningitis bij een allochtoon kind. Tijdschr voor Geneesk 2000; 57: 292-6 K DE BOECK. Kinderen met astma. UZ Gezondheidsbrief 2000; 110: 6-7. 1999 ALIFIER M, DE BOECK K. Tidal breathing analysis in infants and children: a review. Clinical pulmonary medecine 1999; 6: 1-9 DE BOECK K, WARNIER G, ALIFIER M. Is the correct use of a dry powder inhaler (Turbuhaler) age dependent? J All Clin Immunol 1999; 103:763-67 JORISSEN M, DE BOECK K, CUPPENS H. Genotype-phenotype correlations for the paranasal sinuses in cystic fibrosis. Am J Resp Crit Care Med 1999; 159: 1412-16 VAN RAEMDONCK D, VERLEDEN G, VANHAECKE J, DE BOECK K, DAENEN W, DEMEDTS M, COOSEMANS W, DE LEYN P, LERUT T. The current status of lung transplantation. Acta Chir Austriaca 1999; 31: 292-301 VAN BIERVLIET S, EGGERMONT E, CARCHON H, VEEREMAN G, DE BOECK K. Small intestinal brush border enzymes in cystic fibrosis. Acta Gastroenterologica Belgica 1999; 62: 267-271 EVRARD V, CEULEMANS J, COOSEMANS W, DEBAERE T, DELEYN P, DENEFFE G, DEVLIEGER H, DE BOECK K, VAN RAEMDONCK D, LERUT T. Congenital parenchymous malformations of the lung. World J Surg 1999; 23: 1123-32 DE BOECK K Mucoviscidose, een handboek voor zorgenverstrekkers, ouders en patiënten. ACCO ISBN 90-334-4278-7 DE BOECK K. Asthmatische hoest. Semper 1999; 232: 14 DE BOECK K. Mucolytica en mucoviscidose. Semper. 1999; 236:13-14 DE BOECK K. Leukotrienereceptorantagonisten. Percentiel 1999; 4: 119-123 DE BOECK K. Astma bij kinderen. Semper 1999; 229 febr: 8-10

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DE BOECK K. Mucoviscidose en geassocieerde kiemen: beter voorkomen dan genezen? Tempo Medical 1999; 198 febr : 41-43 DE BOECK K. Chronische longziekten bij kinderen : ciliaire dyskinesie. De agenda Pediatrie 1999; maart p1-2. 1998 DE BOECK K, BREYSEM L. Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime.J Antimicrob Chemother1998; 41: 407-409 DE BOECK K, DELBEKE I, EGGERMONT E, VEEREMAN G, GHOOS I. Lipid Digestion in Cystic Fibrosis: Comparison of conventional and high-lipase enzymes using the 13C mixed triglyceride breath test. J Pediatr Gastroenterol and Nutr 1988; 26: 408-411 HELLINCKX J, DE BOECK K, DEMEDTS M. No paradoxical response with forced oscillation technique in children with cystic fibrosis. Chest 1998; 113: 55-59 HELLINCKX J, DEMEDTS M, DE BOECK K. Primary ciliary dyskinesia: evolution of pulmonary function. Eur J Pediatr1998; 157: 422-426 DE BOECK K, SMITH J; VAN LIERDE S, DEVLIEGER H. Response to bronchodilators in clinically stable 1-year old patients with bronchopulmonary dysplasia. Eur J Pediatr 1988; 157: 75-79 HELLINCKX J, DE BOECK K,BANDE KNOPS J, VAN DER POEL M, DEMEDTS M Bronchodilator response in 3-6.5 year old healthy and stable asthmatic children. Eur Resp J 1998; 12: 438-443 DE BOECK K, DELBEKE I, EGGERMONT E, VEEREMAN G, GHOOS I. Lipid Digestion in Cystic Fibrosis: Comparison of conventional and high-lipase enzymes using the 13C mixed triglyceride breath test. Gut 1988; 43: (S3)13 JORISSEN M, DE BOECK K, FEENSTRA L. Middle ear disease in cystic fibrosis. Int J Pediatr Otolaryngol. 1998; 43: 123-128 DE BOECK K, DESAGER K, DE JONGSTE J. Longfunctie-onderzoek bij kinderen.. In: Longfunctieonderzoek. (Demedts M, Decramer M, eds) 1998 ISBN 90-5350-630-6 DE JONGSTE J, DE BOECK K. Mucoviscidose en andere pediatrische pathologieen. In: Longfunctieonderzoek. (Demedts M, Decraemer M, eds) 1998 ISBN 90-5350-630-6 NAULAERS G, VANHOLE C, MOENS M, DEVLIEGER H, DE BOECK K. Definitie, prognose en verwikkelingen bij bronchopulmonale dysplasie. Tijdschr voor Geneesk 1998; 54: 979-988 BARTEN S, DE BOECK K Passief roken bij kinderen. Tijdschrift voor Geneesk 1998; 54: 1323-1328 DE BOECK K De behandeling van astma bij kinderen. Patient care 1998; 21: 73-80 DE BOECK K. Astma en het kind: een consensus. Medisound: het journaal voor de omniprakticus. nr 159 maart 1988 DE BOECK K. Is een algemene opsporing van mucoviscidose bij de geboorte wenselijk. UZ Gezondheidsbrief, 1998; 76: 4-5 DE BOECK K, DEVLIEGER H. Alarmtekens bij een luchtweginfectie. UZ gezondheidsbrief 1998; 84: 7 AVENANT T, DE BOECK K. Niet vaccineren kan tot nieuwe epidemieën leiden. UZ Gezondheidsbrief 1998; 82: 4-6 AVENANT T, DE BOECK K.Veroorzaakt mazelen, bof en rode hond vaccinatie autisme en chronische darmontstekingen? UZ Gezondheidsbrief 1998; 82: 7 1997 BREYSEM L, SMET M, VAN LIERDE S, DEVLIEGER H, DE BOECK K. Evolution of chest radiography and pulmonary function tests in bronchopulmonary dysplasia. Pediatr Radiol 1997; 27: 642-6 DE BOECK K, VAN DER AA N, VAN LIERDE S, CORBEEL L, EECKELS R. Respiratory syncitial virus bronchiolitis : a double blind dexamethasone efficacy study. J Pediatr 1997; 131: 919-921 DE BOECK K, SMITH J, VAN LIERDE S, VAN GYSEL D, DANIELS H, DEVLIEGER H. Response to bronchodilators in clinically stable 1 year old patients with bronchopulmonary disease. Eur J Pediatr 1997; 157: 75-79 DEVRIENDT K, DE SMET L, DE BOECK K, FRYNS JP. Di George syndrome and unilateral symbrachydactyly. Genetic Counseling 1997; 8: 345-347 HELLINCKX J, DE BOECK K, DEMEDTS M. Interstitiele longziekten bij kinderen. Tijdschrift voor Kindergeneeskd 1997; 65:25-29

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DE BOECK K, Longauscultatie. Tijdschr Kindergen 1997; 65: 242-244. DE BOECK K. De therapie van astma bij het kind. In: Astma en het kind BARAN D, BERTRAND JM, DAB I, DEBAETS F, DE BOECK K, LEBECQUE P, VANBEVER H. ( editors) 1997, Moreau pp K DE BOECK. Ernstige hoge en lage luchtweginfecties bij kinderen. In: Respiratoire infecties voor de specialist. Demedts M, Yernault J Eds. Garant, Leuven 1997 pp393-406 DE BOECK K. Cystic fibrosis. Percentiel 1997; 2: 145-146 MOENS M, SCHUDDINCK L, DE BOECK K. Bronchopulmonale dysplasie: een chronisch probleem na verblijf op de eenheid voor neonatale intensieve zorgen. Percentiel 1997; 2: 4-9. HELLINCKX J, DEMEDTS M, DE BOECK K. Sarcoidose bij kinderen. Bloedvaten, Hart, Longen 1997; 2: 148-150 BARTEN S, DE BOECK K. Hoe nadelig is passief roken voor kinderen? UZ magazine 1997; 74: 4-5 BARAN D, BERTRAND JM, DAB I, DEBAETS F, DE BOECK K, LEBECQUE P, VANBEVER H. ( editors) Astma en het kind, Moreau ISBN 90-76279-01-2 1996 REVETS H, VANDAMME P, VAN ZEEBROECK A, DE BOECK K, STRUELENS MJ, VERHAEGEN J, URSI JP, VERSCHRAEGEN G, FRANCKX H, MALFROOT A, DAB I, LAUWERS S. Burkolderia (Pseudomonas) cepacia and cystic fibrosis; the epidemiology in Belgium. Acta Clinica Belgica 1996; 51(4): 222-230. DE BOECK K RSV bronchiolitis: clinical aspects and epidemiology. Monaldi Arch Chest Dis 1996; 51(3): 210-213 DE BOECK K, MOENS M, SCHUDDINCK L. Early Ribavirin Treatment Did Not Prevent Severe Disease in High-Risk Bronchopulmonary Dysplasia Patients With Respiratory Syncytial Virus Infection. Pediatric Pulmonology 1996; 21: 343 DE BOECK K. De kliniek van mucoviscidose. Patient care 1996; 19: 47-58 DE BOECK K, VAN BAELEN A. Subglottis hemangioom. Tijdschrift voor Geneeskunde, 1996; 52: 12: 804-807 1995 DE BOECK K. Croup : a review. Eur J Pediatr 1995; 154: 432-436 DE BOECK K, WILLEMS T, VAN GYSEL D, CORBEEL L, EECKELS R. Outcome after right middle lobe syndrome. Chest 1995; 108:150-152 DE BOECK K, EGGERMONT E, SMET M, VAN REEMPTS P, VAN BEVER H, STEVENS WJ. Specific decrease of anti-pseudomonal IgA after anti-pseudomonal therapy in cystic fibrosis. Eur J Pediatr, 1995; 154(2):157-160. DE BOECK K, VEVECKA E, VAN RAEMDONCK D, MOERMAN PH, LERUT T. Tracheal bronchus associated with cystic adenomatoid malformation. Pediatr Pulmonol. 1995; 20: 413-416 ROELANDT M, DEMEDTS M, CALLEBAUT W, COOLEN D, SLABBYNCK H, J BOCKAERT, J KIPS, J BRIE, M ULBURGHS, DE BOECK K, SIMONS L, VAN MEERBEEK J, VANDEURZEN K, UYDEBROUCK M AND THE WORKING GROUP ON ILD, VRGT, BRUSSEL. Epidemiology of interstitial lung disease (ILD) in Flanders : registration by pneumologists in 1992-1994. Acta Clinica Belgica 1995; 50(5): 260-268 DEVRIENDT K, CUPPENS H, DE BOECK K, FRYNS JP, CASSIMAN JJ. DNA diagnostiek en mucoviscidose. Waar staan we vijf jaar na de identificatie van het mucoviscidosegen ? Tijdschr. voor Kindergeneeskunde 1995; 54: 250-256 HELLINCKX J, DE BOECK K. Leidraad voor behandeling van astma bij kinderen: consensus. Tijdschr. voor Geneeskunde 1995; 51: 709-714 1994 DE BOECK K, SMITH J, VAN LIERDE S, VAN GIJSEL D, DEVLIEGER H. Flat chest in survivors of bronchopulmonary dysplasia. Pediatric Pulmonology, 1994; 18: 104-107. CUPPENS H, TENG HUI, RAEYMAEKERS P, DE BOECK K, CASSIMAN JJ. CFTR haplotype backgrounds on normal and mutant CFTR genes. Human Molecular Genetics, 1994; 3 (4): 607-614. TENG H, CUPPENS H, DE BOECK C, CASSIMAN J.J. Identification of seven rather infrequent and one novel CFTR mutation in the Belgian population. Human Molecular Genetics, 1994; 3(12):2249-2250. VAN GYSEL D, DE BOECK K, LERUT T, WILLEMS T, CARRETTE M, DEVLIEGER H, EGGERMONT E, EECKELS R. Wat wordt er van een kind met congenitale slokdarmatresie ?

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Verslagen Belgische Vereniging voor Kindergeneeskunde, 1994; 26(2):113-114. H. DEVLIEGER, BAYET TH., VAN LIERDE S, DE BOECK K, EUGÈNE CH. On Line assessment of pulmonary function in ventilated newborn infants. Verslagen Belgische Vereniging voor Kindergeneeskunde, 1994; 26(2):143-146. DE BOECK K. Baby’s en allergieen. Goed gevoel. 1994; 5: 24-27 1993 DE BOECK K, DEVLIEGER H, VAN HOLE C, MARTENS M, DE ZEGHER F. Selective Bronchial Intubation for the Treatment of Bronchopleural Fistula in a Preterm Newborn. Chest 1993; 103:1639 DE BOECK K. Correlation between genotype and phenotype in patients with cystic fibrosis (The Cystic Fibrosis Genotype - Phenotype Consortium. New England Journal of Medicine, 1993; 329: 1308-1313. CUPPENS H, MARYNEN P, DE BOECK K, CASSIMAN JJ. Detection of 98.5 % of the Mutations in 200 Belgian Cystic Fibrosis Alleles by Reverse Dot-Blot and Sequencing of the Complete Coding Region and Exon/Intron Junctions of the CFTR Gene. Genomics 1993; 18: 693-697 VAN GYSEL D, DE BOECK K, LERUT T, WILLEMS T, CARRETTE M, DEVLIEGER H, EGGERMONT E AND R. EECKELS. Pulmonary Status During Childhood After Corrected Congenital Esophageal Atresia.In : Recent Advances in Diseases of the Esophagus, eds Nabeya-HanaokaNogami, Springer Verlag, Tokyo, 1993; DE BOECK K, JANSEN HM. Infecties ten gevolge van congenitale deficiënties en aanlegstoornissen. In : Longziekten (Sluiter HJ, Demedts M, Dykman JH, Hilvering C eds.), Van Gorcum (AssenMaastricht) 2° ed 1993:437-445. VEEREMAN G, DE BOECK K, STAS M, DE WEVER I, BOEL M, LERUT T, EGGERMONT E. The use of fow profile button gastrostomy devices in pediatric patients. Acta Gastro-Enterologica Belgica, 1993; 56: C49. SCHOORENS D, DE BOECK K, CASTEELS-VAN DAELE M. Acute otitis media bij kinderen. Tijdschr. voor Geneeskunde 1993;49(24):1741-1745 DEVLIEGER H, DE BOECK K, PROESMANS W, BROCK P, CASTEELS-VAN DAELE M, EGGERMONT E. Sedatie en pijnbestrijding bij de zuigeling en het jonge kind. Verslagen van de Belgische vereniging voor kindergeneeskunde 1993; 25: 83-87 1992 DE BOECK K, JORISSEN M, VANDERSCHUEREN B, WOUTERS K, CASTEELS-VAN DAELE M, CORBEEL L. Aplasia of respiratory tract cilia. Pediatric Pulmonology 1992;13:259-265. RAMET J, PIERARD D, VANDENBERGHE P, DE BOECK K. Comparative study of cefetamet pivoxil and penicillin v in the treatment of group A ß-haemolytic streptococcal pharyngitis. Chemotherapy 1992;38(52):33-37. DENAYER L, EVERS-KIEBOOMS G, DE BOECK K, VAN DEN BERGHE H. Reproductive Decision Making of Aunts and Uncles of a CF-child : Genetic Risk Perception and Attitudes Towards Carrier Identification and Prenatal Diagnosis. Am J Med Genetics 1992;44:104-111. DENAYER L, DE BOECK K, EVERS-KIEBOOMS G, VAN DEN BERGHE H. The transfer of information about genetic transmission to brothers and sisters of parents with a CF-child. In : Psychosocial Aspects of Genetic Counseling. Birth Defects: Original Article Series 1992; volume 28 (1): 149-158 MARTENS M, DE BOECK K, VAN DER STEEN K, SMET M, EGGERMONT E. A right lower quadrant mass in cystic fibrosis : a diagnostic challenge. Eur J Pediatr 1992;151:329-331. VAN DER STEEN K, MARTENS M, DE BOECK K, EGGERMONT E, GEBOES K. De appendix bij mucoviscidose. Tijdschrift voor Geneeskunde 1992; 48(8): 613-615 WOUTERS K, DE BOECK K, CASTEELS-VAN DAELE M. Bruikbaarheid van een verhoogde ASLOtiter. Tijdschr. voor Geneeskunde 1992; 48(21): 1563-1566 DE BOECK K. Astma bij de zuigeling. Medical Trends 1992; 12: 66-72 SMEETS M, UYTTEBROECK A, RENARD M, DE BOECK K, BROCK P, VEREECKEN R, VANDERSCHUEREN-LODEWEYCKX M, CASTEELS-VAN DAELE M. Twee kinderen met vergrote testes. Verslagen Belgische Vereniging voor Kindergeneeskunde 1992; 24(4): 71-73 DE BOECK K. Verkoudheden bij kinderen : vervelend, maar onvermijdelijk. U.Z. Gezondheidsbrief, 1992; 18: 9-10 1991 DE BOECK K, VAN ELDERE S, DEVOS P, MORTELMANS L, CASTEELS-VAN DAELE M.

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Radionuclide bone imaging in toddler's fracture. Eur J Pediatr 1991; 150: 166-169 DE BOECK K, VAN CAUTER A, FIVEZ H, SMET M, EECKELS R. Percutaneous drainage of lung abscess in a malnourished child. Ped Infect Dis J 1991; 10: 163-164 EGGERMONT E, DE BOECK K. Small intestinal abnormalities in cystic fibrosis patients. Eur J Pediatr 1991; 150: 824-828 DE ZEGHER F, DE BOECK K, DEVLIEGER H, VAN DER VOORT E, ELZENGA NJ. Respiratory syncytial virus infection in infants with unbalanced pulmonary perfusion. N Engl J Med (letter) 1991; 324: 1066-1067 JORISSEN M, VAN DER SCHUEREN B, DE BOECK K AND CASSIMAN JJ. Expression of hereditary ciliary abnormalities in cultured nasal epithelial cells. European Respiratory Society (ERS). Brussel , 21-26/09/1991. European Respiratory Journal, 4, suppl 14: p. 522s, abstract 1192n 1991. JORISSEN M, VAN DER SCHUEREN B, DE BOECK K AND CASSIMAN JJ. Expression of primary ciliary dyskinesia - ultrastructural abnormalities in cultured nasal epethelial cells. International congress on Rhinology (IRS), Tokyo, Japan, 23-28/09/1991. Journal of the Japanese Rhinological Society 30: 254, 1991. JORISSEN M, VAN DER SCHUEREN B, DE BOECK K, CASSIMAN JJ The nasal acilia syndrome. J Jap Rhinol Soc 1991; 30: 254 DE BOECK K, VAN CAUTER A, FIVEZ H, SMET M, EECKELS R. Drenaggio percutaneo di un ascesso polmonare in un bambino malnutrito. Pediatr Infect Disease J 1991; 1: 32-33 DE BOECK K. Asthma bij het kind. Tijdschrift voor Geneesk 1991; 47: 113-117 VAN LAER P, DE BOECK K, WOUTERS K, CASTEELS-VAN DAELE M. Groep A streptococcen dermatitis. Verslagen Belgische Vereniging voor Kindergeneeskunde 1991;23:12-13 UYTTEBROECK A, MARTENS M, DE BOECK K, CASTEELS-VAN DAELE M. Een ongewone abdominale tumor bij een adolescente. Verslagen Belgische Vereniging voor Kindergeneeskunde 1991; 23:17-18 DE BOECK K. Sport en de long bij het kind. Limburgs Congres Sportgeneeskunde 1991; 192-194 DE BOECK K. Mucoviscidose : te vroeg voor hoop op genezing ? UZ Gezondheidsbrief 1991; 8: 7 1990 CUPPENS H, LEGIUS E, CABELLO P, MARYNEN P, DE BOECK K, DECORTE R, FRYNS JP, EGGERMONT E, VANDEN BERGHE H, CASSIMAN JJ. Association between XV2c/C27/KM19/D9 haplotypes and the F508 mutation. A study of 57 Belgian families. Hum Genet 1990; 85: 402-403 CUPPENS H, MARYNEN P, DE BOECK K, DE BAETS F, EGGERMONT E, VANDENBERGHE H, CASSIMAN JJ. A child homozygous for a stop codon in exon 11 shows milder cystic fibrosis symptoms than her heterozygous nephew. J Med Genet 1990; 27: 717-719 JORISSEN M, DE BOECK K, VAN DAMME B, LEMAHIEU S, OSTYN F. Empyema of a concha bullosa in a child with cystic fibrosis. Acta otorhino-laryngol Belg 1990; 44:33-36. DENAYER L, DE BOECK K, EVERS-KIEBOOMS G, VANDEN BERGHE H. The transfer of information about genetic transmission to brothers and sisters of parents with a CF-child. Proceedings of Second European Meeting on Psychosocial Aspects of genetics. Leuven, sept 1990; Wiley-Liss ed. DE BOECK K, DEMANDT E, EGGERMONT E. De adolescent met mucoviscidose. Medical Trends 1990; 10: 138-140 DE BOECK K. Boekbespreking : B Lachman (ed) Surfactant replacement therapy in neonatal and adult respiratory distress syndrome. Tijdschr voor Geneeskunde 1990; 46: 453 1989 DE BOECK K, MD, SMET M, MD, AND EGGERMONT E, MD. Treatment of Pseudomonas lung infection in cystic fibrosis with piperacillin plus tobramycin versus ceftazidime monotherapy. Pediatric Pulmonology 1989; 7: 171-173 DE KOSTER J, LEGIUS E, DE BOECK K, MACKEN J, SMET M, EGGERMONT E. De asfyxerende thoracale dystrofie van Jeune. Tijdschr voor Geneesk 1989; 45: 231-234 1988 DE BOECK K, DE MEIRLEIR K. Pneumologische aandoeningen. In : Sportmedische advisering voor bewegingsopvoeding op school. Red R. Lysens. Acco 1988 DE BOECK K, VAN HOESTENBERGHE M, CASTEELS-VAN DAELE M, CORBEEL L. Hypereosinofilie en onverklaarde koorts. Diagnostisch probleem. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 75-76

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DE JAEGERE A, KIMPEN J, WIJNDAELE L, DE BOECK K. Pijnlijke abdominale massa. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 77-78 DEMANDT E, DE BOECK K, CASTEELS-VAN DAELE M, CORBEEL L. Urineretentie na meningitis. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 79-80 DE BOECK K. Piepende peuters. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 94-97 DE BOECK K, EGGERMONT E. Antibioticagebruik bij mucoviscidose. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 153-160 DEMANDT E, DE BOECK K, EGGERMONT E. De adolescent met mucoviscidose. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1988; 20: 219-222 1987 NAGAI A, THURLBECK WM, DE BOECK K, IOFFE S, CHERNICK V. The effect of maternal CO2 breathing on lung development in fetuses in the rabbit. Am Rev Respir Dis 1987; 135: 130-136 DE BOECK K. The perinatal surfactant system. Thesis 1987, Acco Leuven DE BOECK K, CASTEELS-VAN DAELE M. Het syndroom van de zwarte tibia. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1987; 19: 243-249 ZIMMERMAN L, DE BOECK K. Hemophilus influenzae ; Is betalactamase een probleem ? Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1987; 19: 245-249 EGGERMONT E, DE BOECK K, MARIËN P. De voeding van een patiënt met mucoviscidose. Tijdschrift voor Gastro-Enterologie 1987; 17: 359-366 DE BOECK K, EGGERMONT E. Antibioticagebruik bij mucoviscidose. Medical Trends 1987; 10: 7-14 1986 CASTEELS-VAN DAELE M, EGGERMONT E, CASAER P, VAN DE CASSEYE W, DE BOECK K. Acute dystonic reactions and long-lasting impaired consciousness associated with oxatomide in children. Lancet 1986; I: 1204-1205 BATEN E, RAES M, DE BOECK K, CASTEELS-VAN DAELE M. Ziekte van Kohler (osteochondritis van het os naviculare). Een koude zone bij botscintigrafie. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1986; 18: 38-41 1985 RAES M, CORBEEL L, CASTEELS-VAN DAELE M, DE BOECK K, CEUPPENS J. Alopecia totalis, thrombocytopenie en gecombineerde immundeficiëntie. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1985; 17: 155-161 WOUTERS K, DE BOECK K, CASTEELS-VAN DAELE M. Blow-out fractuur. Verslagen van de Belgische Vereniging voor Kindergeneeskunde 1985; 17: 161-162 1984 DE BOECK K, DEGREEF H, VERWILGHEN R, CORBEEL L, CASTEELS-VAN DAELE M. Thrombocytopenia: first symptom in a patient with dyskeratosis congenita. Pediatrics 1984; 67: 898903 DE BOECK K, ZINMAN R, LARSON C, FOX Z. Importance of physician identification of airflow limitation in stable asthmatics. Ann Allergy 1984; 53: 30.34 DE BOECK K, ZINMAN R. Cough versus chest physiotherapy : a comparison of the acute effects of cough versus chest physiotherapy on pulmonary function in patients with cystic fibrosis. Am Rev Respir Dis 1984; 129: 182-184 DE BOECK K, VAN REEMPTS P, RIGATTO H, CHERNICK V. Naloxone reduces decrease in ventilation induced by hypoxia in newborn infants. J Appl Physiol 1984; 56: 1507-1511 JANSEN A, DE BOECK K, IOFFE S, CHERNICK V. Indomethacin-induced fetal breathing : mechanism and site of action. J Appl Physiol 1984; 57: 360-5 1982 DE BOECK K, ZINMAN R, BUREAU M. Strength of the oxygen drive of breathing in longterm cystic fibrosis subjects. Proc Ann Meet Canad Pediatr Soc 1982 Quebec City 1980 VANDENBERGHE G, DE BOECK K, CORBEEL L, EECKELS R. Defective opsonisation in recurrent infections. Acta Pediatr Belg 1980; 33: 219-226 EECKELS R, CORBEEL L, DE BOECK K, CASAER P, EGGERMONT E, LOGGHE N,

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Curriculum Vitae

Christiane De Boeck

VANDEPITTE J, VERBIST L. Intraventricular and or intralumbar treatment of purulent meningitis in infants. Acta Pediatr Belg 1980; 33: 243-251 1979 CORBEEL L, DE BOECK K, LOGGHE N. Treatment of purulent meningitis in infants. Lancet 1979; i 8: 663 1978 FRYNS JP, DE BOECK K, JAEKEN J, VAN DEN BERGHE H. Malformative syndrome associated with a ring 10 chromosome and a translocated 10q/19 chromosome. Hum Genet 1978; 43: 239-244 Projects

CLINICAL TRIALS 1996 : Comparison of the safety profilr of fenoterol-ipratropium administered by lactose inhalets by MDI in pediatric patients with asthma. 1997 : START STUDY : SD-004-0111 Inhaled steroid treatment as regular therapy in early asthma. A study of the effect of early intervention with long-term inhaled Budesonide® (Pulmicort® Turbohaler®) in newly diagnosed asthma. 1998 : A randomized double-blind study to compare the safety and efficacy of Berodual® inhaled via the Respimat® in two dosages with that of Berodual® inhaled via the MDI with Aerochamber® in pediatric patients with asthma. COMIC study : SD – 039- 0353 Efficacy and safety of budesonide/formoterol Turbohaler in a fixed combination in steroid-using asthmatic children. 2000 : RELIEF study : SD-037-0699 Formoterol as relief medication in asthma : a worldwide safety and effectiveness trial. 2001 : PPL-BSSL-CP-002 A Phase Iia, Open Label, Ascending Single Dose, Cross-over Study to Investigate the Activity and Safety of Transgenic Human Bile Salt Stimulated Lipase (tg-hBSSL) compared to Creon® forte in the Treatment of Fat Malabsorption and Steatorrhea in Cystic Fibrosis Patients. Montelukast MK 476-910-01 A double -blind, randomized, double-dummy, multicenter study to evaluate and compare oral Montelukast and inhaled Fluticasone in the control of asthma for 6-14 years old with mild persistent asthma. Clinical Trial 1377 – BRON/HCR 571 3M A double- blind, double-dummy, randomized, parallel-group efficacy and safety study of HFA-BDP delivered by Autohaler® versus Budesonide delivered by Turbohaler® in symptomatic children with mild to moderate asthma. Protocol : D153-P154 A Prospective, Randomized, Open-label, Controlled Trial to Compare the Safety, Tolerability and Efficacy of Influenza Virus Vaccine, Trivalent, Type A&B, Live, Cold-Adapted (CAIV-T) with Influenza Virus Vaccine, Trivalent, Inactivated (TIV) in Children with a History of Recurrent Respiratory Tract Infections aged 6 months to less than 72 months. Influenza vaccine : D 153 –P 515 6 – 17 years old 2002 : Montelukast study on post RSV inflammation 2003 : Montelukast study on post RSV inflammation FMS 40001 A randomized double-blind, double-dummy, parallel-group, multicentre study to compare the effect on growth measured by stadiometry of Fluticasone Propionate (100µg bd) administered via Diskus® with Budesonide (200µg bd) administered via Turbohaler® in prepubescent children. CHESS study : SD -039-0688 Efficacy and safety of Symbicort® (budesonide/formoterol 80/4.5 µg, 2 inh b.i.d.) compared to Pulmicort® (budesonide 100 µg, 2 inh b.i.d.) plus Oxis® (formoterol 4.5 µg, 2 inh b.i.d.) all delivered via Turbohaler® In steroid using asthmatic children. A double blind, double-dummy,

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Curriculum Vitae

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randomized, parallelgroup, multicenter 12 week study. ARX BSSL STUDY : ARX-BSSL-001 An open- label study of the efficacy and safety of different single doses transgenic recombinant human bile salt-stimulated lipase. recBSSL on fat malabsorpition due to chronic pancreatic insuffiency in patients with cystic fibrosis. SMILE STUDY : SD-039-0734 Efficacy of Symbicort® Turbohaler® 160/4,5 µg as needed versus Oxis® 4.5 µg as needed and Bricanyl® 0.4 mg as needed in adults and adolescents with asthma receiving Symbicort® Turbohaler® 160/4.5 µg twice daily as maintenance treatment. A 12 month, randomized, double-blind, parallel-group, active-controlled, phase IIIB, multi –centre study. Protocol: 543.45 A randomized, double-blind, placebo-controlled study to investigate the efficacy and safety of 24 weeks of oral treatment with BIIL 284 BS in adult (75 mg, 150 mg) and pediatric (75 mg) cystic fibrosis patients. 2006 : SAM study : 104926 A multicentre, randomized, double-blind, double-dummy, parallel-group study to compare the Salmeterol/Fluticasone propionate combination (Seretide®)50/100 µg bd and Fluticasone propionate (Flixotide®) 200 µg bd, both delivered via a dry powder inhaler (Diskus®) for 12 weeks in asthma in children aged 4-11 years. 2007 : Protocol PTC 124-GD-006-CF A Phase 2 Study of PTC124 as an Oral Treatment for Nonsense-Mutation-Mediated Cystic Fibrosis. Protocol: ZLB06-005CR A multicenter study on the efficacy and safety of vivaglobin in previously untreated patients (PUPS) with primary immunodeficiency (PID) 2009 : Protocol PTC124-GD-009-CF A phase 3 efficacy and safety study of PTC124 as an oral treatment for nonsense-mutation-mediated cystic fibrosis. Protocol BI 205.339 A randomized, double-blind, placebo-controlled parallel group study to investigate the safety and efficacy of two doses of tiotropium bromide (2.5 µg and 5 µg) administered once daily viat the Respimat® device for 12 weeks in patients with cystic fibrosis. protocol DPM-CF-302 Long term administration of inhaled mannitol in cystic fibrosis – a safety and efficacy study. Protocol VX08-809-101 IND 079521 A randomized, double-blind, placebo-controlled, multiple dose study of VX-809 to evaluate safety, pharmacokinetics, and pharmacodynamics of VX-809 in cystic fibrosis subjects homozygous for the deltaF508-CFTR gene mutation. 2010: Protocol BI 205.438 A randomised, double-blind, placebo-controlled parallel-group trial to confirm the efficacy after 12 weeks and the safety of tiotropium 5 µg administered once daily via the Respimat® device in patients with cystic fibrosis. Protocol VX09-809-102 A phase 2, multicenter, double-blinded, placebo-controlled, multiple-dose study to evaluate safety, tolerability, efficacy pharmacokinetics and pharmacodynamics of VX-809 alone and in combination with VX-770 in subjects with cystic fibrosis, homozygous for the F508del-CFTR mutation. Protocol PTC124-GD-009e CF A Phase 3 Extension Study of Ataluren (PTC124) in Subjects With Nonsense-Mutation-Mediated Cystic Fibrosis 2011 Protocol TR02-108 Randomized, Open-Label, Active-Controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of Arikace™ in Cystic Fibrosis Patients With Chronic Infection Due to Pseudomonas Aeruginosa 2012: Protocol ALPINE GS-US-205-0162

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Open-Label Phase 2 Trial to Evaluate the Safety and Efficacy of Aztreonam 75 mg Powder and Solvent for Nebuliser Solution/Aztreonam for Inhalation Solution (AZLI) in Pediatric Patients with Cystic Fibrosis (CF) and New Onset Lower Respiratory Tract Culture Positive for Pseudomonas aeruginosa (PA) Protocol VX12-770-111 A Phase 3, two-part, Randomized, Double-Blind, Placebo-Controlled, Crossover Study With an OpenLabel Period to Evaluate the Efficacy and Safety of Ivacaftor in Subjects with Cystic Fibrosis Who Have a Non-G551D CFTR Gating Mutation Phase III Study to Evaluate Clinical Efficacy and Safety of Avian Polyclonal Anti-Pseudomonas Antibodies (IgY) in Prevention of Recurrence of Pseudomonas Aeruginosa Infection in Cystic Fibrosis Patients Protocol TR02-110 Long Term Safety and Tolerability of Open-Label Liposomal Amikacin for Inhalation (Arikace™) in Cystic Fibrosis Patients With Chronic Infection Due to Pseudomonas Aeruginosa 2013: Protocol DPM-CF-204 A phase 2, randomised, multicentre, double-blind, placebo-controlled, crossover study determining the efficacy of dry powder Mannitol in improving FEV 1 in subjects with Cystic Fibrosis aged six to seventeen years DPM-CF-204 Protocol VX12-770-112 Rollover Study of Ivacaftor in Subjects With Cystic Fibrosis and a Non G551D CFTR Mutation (KONTINUE) Protocol VX12-809-104 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Lumacaftor Monotherapy and in Combination with Ivacaftor in Subjects Aged 12 Years and Older with Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation 2014 Protocol VX12-809-105 A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis PTC124-GD-021 A phase III Efficacy and Safety Study of Ataluren (PTC124®) in Patients with Nonsense Mutation Cystic Fibrosis PTC124-GD-023 An Open-Label Safety and Efficacy Study for Patients with Nonsense Mutation Cystic Fibrosis Previously Treated with Ataluren (PTC124®) International projects/ working groups European Coordination Action For Research in Cystic Fibrosis (EuroCareCF): Leader of WP3 (Coordination of Clinical Research) ECORN (www.ecorn-cf.eu) European Clinical Trials Network Co-founder of the European Clinical Trials Network and first director of this network Member ECFS Diagnostic Network Working Group Member Educational steering group www.cftr.info Member of Scientific Committee European Cystic Fibrosis Conferences Member faculty Ahead of the Curve (http://dkbmed.com/AOTCblog/?p=5) Member of consensus working groups leading to publication of several consensus reports Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus Journal of Cystic Fibrosis 2009; 8 : 295-315 A European consensus for the evaluation and management of infants with an equivocal diagnosis following newborn screening for cystic fibrosis

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Curriculum Vitae

Christiane De Boeck

Journal of Cystic Fibrosis 2009; 8 : 71-78 Clinical trials in cystic fibrosis Journal of Cystic Fibrosis 2007; 6: 85-90 Standards of care for patients with cystic fibrosis: a European consensus Journal of Cystic Fibrosis 2005; 4: 7-26 Early intervention and prevention of lung disease in cystic fibrosis: a European consensus Journal of Cystic Fibrosis 2004; 3: 67-91 Memberships

Memberships 1982 American Thoracic Society 1984 Flemish Pediatric Society 1987 Belgian Pediatric Society 1987 Belgian Pediatric Pulmonology Society 1990 European Respiratory Society 1998 European Society for Cystic Fibrosis

Other Relevant Information

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