PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET

Science Market Regulation

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2015 Marketing development Strategy consulting Partnership searches Information systems

U B I C Technical & Competitive Scanning – Regulations – Manufacturers Technical & Competitive Scanning – Regulations – Manufacturers CONSULTING

This comprehensive report is based on in-depth interviews with food companies completed by a desk review. It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future.

MARKET ANALYSIS New trends and perspectives Usage of ingredients: volume -value Production volumes by country Suppliers Dietetic, Medical and Sports food manufacturers company profiles

COUNTRIES COVERED North America Western Europe

North America Western Europe

FOOD SEGMENTS Infant formula Dietetic & Sport & Slimming Foods Clinical Nutrition

INGREDIENTS COVERED Whey protein hydrolysate Casein hydrolysates Meat Protein Hydrolysate

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OBJECTIVES M A R K E T

Food consumption trends and expectations Consumer market trends by food segments Prospective MANUFATURERS

Food industry orientations Applications in food segments Consumption RESEARCH

New researches and new developments

PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET DESCRIPTION Milk protein hydrolysates are a group of peptides derived from milk proteins. There are two sources of milk protein hydrolysates: whey protein hydrolysates and casein hydrolysates. NUTRITIONAL PROPERTIES Peptides may be absorbed slightly better and more quickly than amino acids or whole protein. This is due to the fact that di- and tripeptides can be directly absorbed from the gut by uptake systems that are independent of those used by amino acids. Moreover, recent studies have found that rats grow more rapidly when fed with isocaloric and isonitrogenous quantities of peptide diets as compared to intact protein and amino acids based diets. NUTRACEUTICAL PROPERTIES Both whey protein hydrolysates and hydrolysates have low antigenic properties.

casein

Symptoms Cow milk protein allergy (CMPA) is characterized by a wide range of symptoms and signs affecting the gastro-intestinal tract, the respiratory system and the skin. Symptoms include those commonly associated with immunoglobulin E (IgE)- associated reactions, and Non-IgE-associated, immunological mediated conditions. All proteins are potentially allergenic. Unmodified cow's milk itself contains more than 32 proteins of high allergic potential that may induce CMPA.

The three most important are:

Those proteins are indeed more frequently allergenic than bovine serum albumin (68 kDa), lactoferrine, and gammaglobulines…

PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET

Meat Protein Hydrolysate OBJECTIVES M A R K E T

Food consumption trends and expectations Consumer market trends by food segments

The protein hydrolysates most commonly used in nutritional products are casein, whey protein and soy protein. The use of other sources of protein hydrolysates, derived from animal sources, is an area of growing interest. Up to 50% of the animal weight processed in the meat industry is discarded as left-overs and ends up composted or incinerated, despite being rich in proteins and lipids. So the focus is now on reusing proteins.

Prospective MANUFATURERS

Food industry orientations Applications in food segments

•Meat Protein Hydrolysate differ from existing protein hydrolysates, from eggs, buttermilk, or fish already on the market in that they have a higher content of nutritionally useful amino acids.

Consumption RESEARCH

New researches and new developments

•So far, some of their other properties—namely prebiotic, antimicrobiotic, antioxidant and hypertensive—have been demonstrated in vitro.

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OBJECTIVES M A R K E T

MARKET Food consumption trends and expectations Consumer market trends by food segments Prospective MANUFATURERS

Food industry orientations

CLINICAL NUTRITION During the common process of nutrition, dietary proteins are presented to the immune system via the gut, followed by an immune unresponsiveness to the ingested nutrients. This vital phenomenon, called oral tolerance, is efficient for the large majority of people. If oral tolerance fails, food allergy occurs, requiring the strict avoidance of the incriminated food. Targeted food avoidance represents a hard task for adult patients with food allergy. For example, to strictly remove cow's milk from the diet of allergic infants might be even more difficult, especially if breastfeeding is not possible or desired.

Applications in food segments

SPORTS FOOD Hydrolysates present, besides a faster digestibility, the advantage of maintaining a higher biological value of the proteins. This is particularly true for whey, which is also less concerned by the speed of digestibility since non hydrolysed proteins are already rapidly digested at the beginning of the duodenum. INFANT NUTRITION Protein allergy is more than a tolerance problem. It means that the infant's immune system has responded in an abnormal way to the protein in his/her diet. This can happen with both milk-based and soy-based formulas, and it tends to run in families. What happens is that the baby's immune system identifies the "whole" protein in his/her formula as foreign. His/her immune system responds much like it would to a virus — and manufactures antibodies in defence.

Trends in Infant Formula

Consumption RESEARCH

Hypo allergenic

Hypoallergenic formula : A Growing segment But still limited ( Under 15% Market share on a global market basis )

New researches and new developments

Growing -Up

Growing up on formula is the Fastest growing Segment ( Double digits growth in volume )

PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET OBJECTIVES M A R K E T

CASEIN APPLICATIONS – MARKET SIZE

Food consumption trends and expectations

World Hydrolysate Market – 2013 Accessible market Nutrition Segment

Consumer market trends by food segments Prospective MANUFATURERS

Food industry orientations

Finished products market volume In tons and or Value (USD)

Total protei ns

USA/Oth ers

J

Whey Hydrolysat e consumpti on in tons

EU

Casein

Hypoallegenic Infant formula Clinical nutrition Nutrition Bars

Clinical Nutrition

Consumption Body building

New researches and new developments

Market value in US$ mio

Nutraceutival s

Applications in food segments

RESEARCH

Fish Hydrolysat e

Nutraceuticals Others (Microbiologica l culture media) Total

Sport Food

Infant Formula

PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET

OBJECTIVES M A R K E T

Production by country and ingredient Category

Food consumption trends and expectations Consumer market trends by food segments Prospective MANUFATURERS

Food industry orientations Applications in food segments

Suppliers profiles and market shapes

Table of Contents

Consumption RESEARCH

New researches and new developments

Food Company profiles detailing their expectations towards product and service

Milk and Whey Protein Hydrolysate consumption by country and food segment

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TABLE OF CONTENT EXECUTIVE SUMMARY 1.1.Whey protein hydrolysates presentation 1.2.Market Clinical nutrition Infant formula Sport nutrition Suppliers

8 9 13 15 19 29 33

INTRODUCTION 35 1.3.Objectives 36 1.4.Definition 36 1.5.Whey protein hydrolysates properties 37 Description 37 Nutritional Properties 37 Nutraceutical properties 37 Cow’s milk allergy 37 Hydrolysates and allergy reduction 39 1.6.Techno-Functional Properties of Protein Hydrolysates 44 1.7.Protein hydrolysates manufacturing 47 Introduction 47 Current Practices of Different Manufacturing Methods of Protein Hydrolysates 47 Generic Flow of Manufacturing Process of Protein Hydrolysates 49 Future Trends 54

1.8. Meat protein hydrolysates 56 Methods of hydrolysate 56 Properties of meat protein hydrolysate 57 The main objectives for using Meat Protein Hydrolysates 58 Applications 59 Suppliers 62 Main users of Meat Protein Hydrolyzates 63 CLINICAL NUTRITION MARKET 67 1.9.Hydrolysates market 68 Companies using hydrolysates and summary of product usage 69 1.10. Company profiles 73 ABBOTT NUTRITIONALS (US) 74 CLINICAL NUTRITION (ESP) 77 DANONE MEDICAL NUTRITION (NL) 78 FRESENIUS KABI ENTERAL NUTRITION (G) 88 NESTLE HEALTH SCIENCES (CH) 99 INFANT NUTRITION MARKET 109 1.11.HA formula market 110 1.12.Hydrolysates market 112 ·Compagnies marketing HA products 118 ·Internal production vs outsourcing 119 1.13.Company profiles 121 ABBOTT NUTRITIONALS (USA) 122 ABBOTT NUTRITIONALS (SP) 132 DANONE (BLEDINA - F) 133 FARLEY’S (UK) 138 FRIESLAND CAMPINA(NL) 140

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PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET

HIPP WERKE (G) 144 HOCHDORF NUTRICARE (CH) 147 HUMANA MILCHUNION eG (G) 149 HYPROCA LYEMPF (NL) 155 DANONE (Royal NUMICO NL) 157 MEAD JOHNSON NUTRITIONALS (NL) 168 MEIJI DAIRIES Corp (J) 175 MORINAGA MILK Ind Co (J) 180 NESTLE (CH) 185 NUMICO- COW & GATE 190 DANONE (NUMICO – MILUPA- UK) 193 LACTALIS PULEVA (SP) 196 ORKLA FOODS 197 SODILAC (ORDESSA GROUP) (F) 199 STAR (DANONE Group - IT) 202 VALIO (DANONE FIN) 204 SPORT NUTRITION MARKET 206 1.14.Hydrolysate market 207 1.15.Company profiles 212 INKO SA – NUTRICHEM (G) 213 WIEDER GLOBAL NUTRITION (G) 218 REFLEX NUTRITION (UK) 221 BARIATRIX (CDN) 223 BEST FOOD- SLIM FAST FOOD UNILEVER (UK) 226 BESTPROTEIN (SP) 228 BIODYNAMICS NV (METAGENETICS GROUP - B)230 CAMBRIDGE MANUFACTURING COMPANY Ltd (CMC ) (UK) 233 DHC NUTRITION (F) 236 EUROSUP (I) 238 GEFA LABORATORY (F) 240 GENSAN S.R.L. (ABIOGEN GROUP) (I) 241 HALO FOODS (UK) 243 INSUDIET (F) 245

HEDELAB (B) 247 LABORATOIRE EA PHARMA (F) 249 LABORATOIRES FENIOUX (F) 250 LABORATOIRE ROBERT SCHWARTZ (F) 252 MAXIMUSCLE Ltd. (UK) 255 NATURE’S BEST (QNT) 257 AMERICAN PREMIER NUTRITION/ MLO Sports Nutrition (USA- CH) 258 NUTRISPORT (UK) 262 NUTRISUN (TRIBALLAT GROUP - F) 264 PROSPORT (G) 266 SHANNON MINERALS (IRL) 269 LABORATOIRES PYC /SOBAL (F) 272 SPONSER SPORT FOOD (CH) 274 TWINLAB MJJ Power (B) 277 VITAPHAR (B) 278 BIOTECHNOLOGY APPLICATION 279 1.16.Protein hydrolysates 280 KERRY (USA) 281 FUNCTIONAL FOOD AND SUPPLEMENTS 283 1.17.Definition of functional food 284 1.18.Physiological effects of bioactive peptides 285 1.19.Exemple hydrolysates of companies commercializing functional supplement containing protein: 287 -Exemple 1: Glanbia Nutritionals Ingredient Technologies 287 -Exemple 2: Arla Food ingredients Compagny 288 -Exemple 3: American Casein Company 289 -Exemple 4: Carbery Ingredients Compagny 289 -Exemple 5: Pharmachem Laboratories Inc. Compagny 289 -Exemple 6: Davisco Compagny 290 -Exemple 7: Chaitanya Chemicals Compagny 290

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PROTEIN HYDROLYSATE INGREDIENT MARKET PROTEIN HYDROLYSATE INGREDIENT MARKET TABLE OF CONTENT

INGREDIENT MANUFACTURERS 291 1.20.Main suppliers of Whey hydrolysates 292 ARMOR PROTEINES (F) 294 DAVISCO (USA) 296 FRIESLAND CAMPINA (NL) 298 THE ARNHEM GROUP (USA) 301 FONTERRA (NZ) 302 KERRY INGREDIENTS (IRL) 307 GLANBIA INGREDIENTS (IRL) 310 HILMAR INGREDIENTS (USA) 317 LEPRINO FOODS (USA) 319 NEW ALLIANCE DYE CHEM PVT. LTD. (IND) 321 PGP International (ABF Ingredient - USA) 323 PROTECH NUTRACEUTICALS (IND) 325 TATUA (NZ) 327 INDIAN MANUFACTURERS PROFILES 329 10. Meat Protein Hydrolysates 341 1.21.Main suppliers of Meat Hydrolysates 342 PROLIVER 343 Proliant Health & Biologicals 345 ROUSSELOT 348 Kerry Ingredients India 350 11REGULATION 352 COMMISSION REGULATION (EC) No 1609/2006 353

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LISTE OF TABLES Table 1 : World Hydrolysate Market – 2013 Accessible market Table 2: Wholesale price in US$ Table 3: Use of hydrolysates in enteral nutrition Table 4: Summary of interviews – technical properties for main manufacturers in clinical nutrition Table 5: World Clinical & Enteral Nutrition Companies – use of hydrolysates Table 6: HA Infant Formula markets -2013 - in tons Table 7: World babymilk consumption of Hydrolysates in tons – 2013 Table 8: Trends in usage of milk protein hydrolysates in hypoallergenic formulas Table 9: Companies using hydrolysates and summary of product usage in infant formula Table 10: Companies using hydrolysates in the sports food market and summary of product usage Table 11: Main suppliers of Whey hydrolysates Table 12: Symptoms of cow’s milk allergy Table 13: Hypoallergenic formulae: different types and properties Table 16 : Clinical nutrition Hydrolysate Market - 2014 Table 17: Use of hydrolysates in enteral nutrition Table 18: Adult Clinical Nutrition Formula Table 19: Summary of interviews – technical properties for main manufacturers in clinical nutrition Table 20: World Clinical & Enteral Nutrition Companies – use of hydrolysates Table 21: HA Infant Formula markets -2013- in tons Table 22: World babymilk consumption of Hydrolysates in tons – 2014 Table 23: Trends in usage of milk protein hydrolysates in hypoallergenic formulas Table 24: Companies using hydrolysates and summary of product usage in infant formula Table 25: Main suppliers of Whey hydrolysates Table 26: Companies using hydrolysates in the sports food market and summary of product usage Table 27: Summary of interviews – technical properties of hydrolysates in sports nutrition

LISTE OF FIGURES Figure 1: Hydrolysate Market Breakdown – 2014 Figure 2: Trends in infant formula Figure 3 Typical manufacturing overview of protein hydrolysates

14 20 50

13 14 16 17 18 19 20 21 22 30 33 38 41 68 69 70 71 72 111 112 113 114 119 208 211

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