Treatment of HIV and acute myeloid leukemia by allogeneic CCR5-d32 blood stem cell transplantation Elena Knops
Elena Knops, GfV 2016
Background - the Berlin patient – so far the only person presumed to be cured from HIV by hematopoietic stem cell transplantation (HSCT) from a homozygous CCR5-d32 donor
Elena Knops, GfV 2016
Background - the Berlin patient – so far the only person presumed to be cured from HIV by hematopoietic stem cell transplantation (HSCT) from a homozygous CCR5-d32 donor - failed attempts to reproduce cure by HSCT - viral rebound or death due to underlying malignancy
Elena Knops, GfV 2016
Background - the Berlin patient – so far the only person presumed to be cured from HIV by hematopoietic stem cell transplantation (HSCT) from a homozygous CCR5-d32 donor - failed attempts to reproduce cure by HSCT - viral rebound or death due to underlying malignancy - THE question about all of these attempts and the Berlin patient: How to be sure about the cure? Is there any virus in the patient?
Elena Knops, GfV 2016
The whole story (drama in 4 acts) 46y old patient alive, well and undetectable for HIV (RNA/DNA) over 3 years after allogeneic CCR5-d32 HSCT
Elena Knops, GfV 2016
The beginning (prologue) induction
consolidation
Elena Knops, GfV 2016
The beginning (prologue) induction
consolidation
Elena Knops, GfV 2016
The beginning (prologue) induction
consolidation
Elena Knops, GfV 2016
Chapter I female donor, 10 out of 10 HLAmatched CCR5-d32
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one week before SCT
Elena Knops, GfV 2016
Chapter I female donor, 10 out of 10 HLAmatched CCR5-d32
....
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one week before SCT
Elena Knops, GfV 2016
Chapter I female donor, 10 out of 10 HLAmatched CCR5-d32
....
....
one week before SCT
Elena Knops, GfV 2016
Chapter I female donor, 10 out of 10 HLAmatched CCR5-d32
....
....
one week before SCT
Elena Knops, GfV 2016
Chapter II
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Elena Knops, GfV 2016
Chapter II total of 8 courses of 5-azacytidine + 4 donor lymphocyte infusions
