TM

CREATIVE GROUP

TM

CREATIVE GROUP

Design • Manage • Produce eom creative group is about design, function, execution and client service. Our experiences span numerous industries, from education to technical consumer products and services – including biomed, engineering and software – to health, beauty, food and wine. Everything we do is predicated upon our client’s vision. It is our job to manifest it. There is no limit to what eom creative group can produce to enhance your marketing programs. • Collateral and digital design • Sales tools and training • Tradeshow design and management • Advertising and PR — creative and campaign development • Video production

Please contact: Cyndie Wooley 415.233.3211 eom creative group 107 Water Street 2M Petaluma, CA 94952 [email protected]

www.eomcreative.com

eom creative group

Corporate identity Web design Website development

eom creative group

Corporate identity Web design Website development Marketing collateral Advertising Copy writing

eom creative group

Corporate identity Rebranding Web design Marketing collateral Copy writing

eom creative group

Website development • ecommerce • emarketing campaigns

eom creative group

Corporate identity Branding Web design Graphics Mobile applications

eom creative group

Corporate identity Branding Web design Graphics Mobile applications

Technology in Sync The Power of Combined Performance Medtronic’s coronary product suite combines the balanced performance of guide catheters, the recognised crossability of an advanced line of guidewires, sophisticated balloon technology and revolutionary stent engineering— creating a synchronised approach for today’s coronary interventions.

Coronary Product Suite Advanced crossing technology for complex and workhorse cases Launcher GUIDE CATHETER

Intuition

ADVANCED WORKHORSE GUIDEWIRE

ProVia CROSSING GUIDEWIRE

Sprinter Family BALLOON DILATATION CATHETERS

Integrity CORONARY STENT SYSTEM

Endeavor Sprint ZOTAROLIMUSELUTING CORONARY STENT SYSTEM

eom creative group

Interactive mobile/app design and development

eom creative group

Art direction Design Illustration

eom creative group

Art direction Design Illustration

Coronary Artery Disease

Understanding Your Stent Procedure Patient Guide

Integrity® CoRoNARy STENT SySTEM

eom creative group

Design Production Medical / technical illustration Marketing collateral

Transradial Curve Family

Choosing a transradial curve should be simple. We can help.

LAuncHEr AnD SHErPA nX GuiDE cATHETErS

Medtronic Ordering Information Contact your Medtronic sales representative. Curve

Medtronic is the worldwide leader in guide catheters. Medtronic is the worldwide leader in guide catheters. When it comes to choosing a transradial guide catheter, the choice should be simple—Medtronic. Our family of guide catheters is appropriate for transradial procedures, allowing you to navigate a variety of anatomies. A broad range of radial shapes is available—and custom lengths and shapes can be ordered—to satisfy the majority of cases.

EBU

LArA ALr12 MrADiAL MRESS

A Full Line of Guide Catheters

rrAD

Medtronic’s multiple guide catheter platforms provide options for guide engagement. MAC Supportive secondary curve

MAC3030

Launcher Guide Catheter • Large lumens with no performance tradeoffs

HOCKEY STICK

• Flexible distal segment to engage the guide for backup MuLTiPurPOSE IMA

• Supportive secondary curve

riGHT cOrOnArY curvES Supportive secondary curve

Transradial Curve Family

Mid-range flexibility

MAC Curve

Sherpa NX Guide Catheter

LAuncHEr AnD SHErPA nX GuiDE cATHETErS

Supportive secondary curve

Mid-range Workhorse catheter flexibility • Two distal segments to provide options for guide engagement for the right coronary artery • Soft tip and distal sleeve to facilitate ease of engagement Active flexibility

Guide catheters from Medtronic are the no. 1 choice worldwide—and are suitable for transradial • Advanced HDPE liner for smooth, low-friction device passage procedures. The majority of cases can be addressed with just a few basic curve shapes.

EASY rADiAL LEFT

Sherpa NX Active 5F 6F SA5EBU30 SA6EBU30 SA5EBU35 SA6EBU35 SA5EBU375 SA5EBU40

SA6EBU375 SA6EBU40

LA6EBu46

SA5EBU45

SA6EBU45

Soft tip

LA5EBu50 LA5LArA

LA6EBu60 LA6LArA

SA5EBU50 SA5LArA

SA6EBU50 SA6LArA

SB6EBU50 SB6LArA

LA5ALr12 LA5MrADiAL

LA6ALr12 LA6MrADiAL

SA5ALr12 SA5MrADiAL

SA6ALr12 SA6MrADiAL

SB6ALr12 SB6MrADiAL

LA5MrESS LA5rrAD

LA6MrESS LA6rrAD

SA5MRESS SA5rrAD

SA6MRESS SA6rrAD

SB6MRESS SB6rrAD

LA5MAc30 LA5MAc35 LA5MAc375 LA5MAc40

LA6MAc30 LA6MAc36 LA6MAc376 LA6MAc40

SA5MAC30 SA5MAC35 SA5MAC375 SA5MAC40

SA6MAC30 SA6MAC35 SA6MAC375 SA6MAC40

SB6MAC30 SB6MAC35 SB6MAC375 SB6MAC40

LA5MAc45 LA5MAc3030 LA5HSi LA5HSii LA5HSrEL

LA6MAc46 LA6MAc3030 LA6HSi LA6HSii LA6HSrEL

SA5MAC45 SA5MAC3030 SA5HSI SA5HSII SA5HSrEL

SA6MAC45 SA6MAC3030 SA6HSI SA6HSII SA6HSrEL

SB6MAC45 SB6MAC3030 SB6HSI SB6HSII SB6HSrEL

LA5HSiii LA5MPST LA5iMA LA5ErADL LA5ErADLLT

LA6HSiii LA6MPST LA6iMA LA6ErADL LA6ErADLLT

SA5HSIII SA5MPST SA5IMA SA5ErADL SA5ErADLLT

SA6HSIII SA6MPST SA6IMA SA6ErADL SA6ErADLLT

LA5ErADLST LA5ErADr LA5ErADrST

LA6ErADLST LA6ErADr LA6ErADrST

SA5ErADLST SA5ErADr SA5ErADrST

SA6ErADLST SA6ErADr ALr12 SA6ErADrST

Backup support is derived from the contralateral wall5A0034 and sinus 6A0036 of valsalva. Appropriate sizing suggestions: BrAcHiAL 4.0 • Lateral takeoff and small root: MAc3.0 (one sidehole) • Superior takeoff and small root: MAC3.5/4.0 • Superior and large root: MAC4.0 • Lateral and large root: MAc3.5/4.0

Medtronic’s complete line of guide catheters incorporates full-wall technology. The unique shaft construction optimizes the balance between a large lumen and robust performance, and offers excellent General guide manipulation tip: The transradial approach can involve more kink resistance and curve retention. tortuosity than the femoral approach. Guide manipulation from the radial

artery requires small clockwise and counterclockwise torquing movements. A fingertip technique is recommended rather than the wrist technique The inner and outer jackets encapsulate the flat routinely used for the femoral approach. braid wire, affording thinner, stronger walls.

BrAcHiAL 4.5 (one sidehole)

Inner jacket

More polymer Encapsulated wire Curve Judkinsbraid Right

EBU Extra Backup Curve

Standard curve for right coronary arteries (may be particularly useful for inferior takeoffs)

Recommended engagement technique The EBU catheter enters the descending aorta facing the right coronary artery. Make a large J-shaped loop in the sinus of valsalva with the 0.035 J-tipped wire and advance the catheter over the wire. Apply torque to point the tip to the left coronary cusp and turn the catheter. Pull the wire back and the catheter will engage the left coronary artery.

Sherpa NX Balanced 6F SB6EBU30 SB6EBU35 SB6EBU375 SB6EBU40

Transradial Curve Family

SB6EBU45

LAuncHEr® AnD SHErPA nX GuiDE cATHETErS

SB6HSIII SB6MPST SB6IMA SB6ErADL

Medtronic Offers a Full Line of Transradial Curves SB6ErADLLT SB6ErADLST SB6ErADr SB6ErADrST

MRESS

rrAD

IMA

Hockey Stick

MrADiAL

LArA

Easy Radial right

Easy Radial right short tip

To further simplify your transradial approach needs, Medtronic offers the following brachial curve Recommended engagement technique shapes that can be used for left and right angiographies. Additional Enter the root with the catheter tip facing the left coronary Curveor the left coronary Catalog Number French Size Length (cm) cusp. Once in the non-coronary cusp cusp, transradial 4A0052 4 80 pull the wire back and apply clockwise torque. The catheter tip curves 5A0052 5 80 should deflect to the right coronary cusp and engage the right 6A0054 6 80 BrAcHiAL 3.5 Sherpa NX Balancedcoronary artery. (one sidehole) 4A0034 4 100

Sherpa NX Active

LEFT cOrOnArY curvES

Launcher

Soft tip

The transradial approach has advantages for both diagnostic and interventional procedures, including: Unique Full-Wall Technology Reduced bleeding Lowered vascular complications Early ambulation Reduced costs

Workhorse guide catheter for left coronary arteries

EASY rADiAL riGHT

6F LA6EBu30 LA6EBu36 LA6EBu376 LA6EBu40

LA5EBu45

Flat braid wire

Outer jacket

5 6

100 100

4A0053 5A0053 6A0055 4A0035

4 5 6 4

80 80 80 100

5A0035 6A0037

5 6

100 100

4A0054 5A0054 6A0056 4A0036

4 5 6 4

80 80 80 100

5A0036 6A0038

5 6

100 100

MAC3030

For further information, please call and/or consult Medtronic

at the technique toll-free numbers or websites listed below: Recommended engagement Employ a Judkins engagement technique similar to the femoral www.medtronic.com approach. Apply a clockwise rotation to engageMedtronic the rightBV Medtronic Vascular 3576 Unocal Place Earl Bakkenstraat 10 coronary artery. Santa Rosa, CA 95403 USA

Tel: +1.707.525.0111 Sizing suggestions: • Same as femoral approach

6422 PJ Heerlen The Netherlands Tel: +31.45.566.8000 Fax: +31.45.566.8668

Backup support with the transradial approach is derived from the sinus of valsalva, while EBU backup support with the femoral approach comes from the contralateral wall.

Indications for Use: Medtronic guiding catheters are designed to provide a pathway through which therapeutic devices are introduced. The guiding catheters are intended to be used in the coronary or peripheral vascular system.

Easy Radial left

Easy Radial left long tip

Adverse effects: Use of guiding catheters may give rise to the following complications: hemorrhage or hematoma, allergic reaction to contrast medium, infection, embolism, vessel or heart dissection, perforation, vessel spasm, thrombosis, myocardial infarction, stroke, death and vascular occlusion. Refer to Instructions for Use supplied with the device for indications, warnings, precautions, and adverse effects. CAUTION: Federal (USA) law restricts this device to sale by or on the order of a physician.

Test data on file at Medtronic, Inc. Easy Bench test results may not be indicative of clinical performance. The curve recommendations in this guide are not meant to replace patient-specific clinical judgment. Radial curves

For distribution in the USA. © 2010 Medtronic, Inc. All rights reserved. Printed in US. UC201004448EN 2/10

Mid-range flexibility

5F LA5EBu30 LA5EBu35 LA5EBu375 LA5EBu40

Easy Radial left short tip

Sizing suggestions: • JL35 = EBu35 • JL40 = EBu35 • JL50 = EBu40

Judkins Left Curve

Multipurpose Short Tip (MPST) Curve

Recommended engagement technique Employ a Judkins engagement technique similar to the femoral approach. very fine torquing movements may be required to direct the catheter toward the left coronary artery.

Standard curve for left coronary arteries (may be particularly useful for short left coronary arteries)

Standard curve for right coronary arteries (may be particularly useful for inferior takeoffs)

Sizing suggestions: • Downsize the curve by 0.05 from what is used for the femoral approach

The brachial curve shape, available in the SiteSeer® angiographic catheter, can be used as a universal diagnostic catheter for right and left angiographies. Recommended engagement technique Use a gentle clockwise rotation technique similar to the Judkins right coronary approach and the MAC. Pullback is required to carefully engage the artery.

Universal diagnostic catheter

Sizing suggestions: • Same as for femoral approach Clear pocket

TECHNICAL SPECIFICATIONS

SYMPLICITY HTN-4 Trial

Symplicity G3™

Renal Denervation (RDN)

RENAL DENERVATION GENERATOR

CATheTeR-bASed TReATMeNT FOR UNCONTROlled hypeRTeNSION

The Symplicity G3™ generator, an integral part of the Symplicity™ renal denervation system, is designed to deliver precisely controlled radiofrequency (RF) energy treatments using either the Symplicity Spyral™ catheter or the Symplicity Flex™ catheter PRODUCT DESCRIPTION The Symplicity G3 generator is an automatically-controlled electrosurgical generator that produces RF energy according to a programmed algorithm. During energy delivery, power is continuously monitored and controlled based on temperature and impedance measured at the electrode-tissue interface to ensure proper operation.

AC power connector

The Symplicity G3 generator consists of:

MATERIALS

FOOT SWITCH

The nerves leading in and out of the kidneys play a central role in sympathetic nervous system (SNS) hyperactivation, which is an established contributor to hypertension (high blood pressure).* The SNS connects the brain, heart, blood vessels and kidneys—each of which plays an important role in the regulation of the body’s blood pressure. Surgical disruption of sympathetic nerves has been a proven method for lowering blood pressure.† Renal denervation with the Symplicity® renal denervation system from Medtronic represents a breakthrough and first-of-its-kind device, currently under investigation in the United States for uncontrolled hypertension; a significant global healthcare problem affecting approximately 1.2 billion people worldwide and directly associated with increased risks of heart attacks, stroke, heart failure, kidney disease and death.‡

How does renal denervation work?

• Generator • Optional foot switch

GENERATOR

Renal DeneRvation WitH tHe Symplicity® Renal DeneRvation SyStem What is the rationale for renal denervation?

• Painted and nonpainted sheet metal • Polycarbonate/acrylonitrile butadiene styrene blend (external covers) • Krapton thermoplastic elastomer (cord management strap) • Glass (projected capacitance touchscreen) • Painted sheet metal • PVC (foot switch hose) • Nylon

CABLE

REGION

AC POWER CABLE

USA

LENGTH (mm) 3.0

ALTERNATE AC POWER CABLE

EU

2.5

PRODUCT CODE PRT075-2

PRT075-1

India

2.5

PRT075-3

Australia

2.5

PRT075-4

UK/Ireland

2.5

PRT075-5

Italy

2.5

PRT075-6

Switzerland

2.5

PRT075-7

Israel

2.5

PRT075-8

Denmark

2.5

PRT075-9

Renal denervation reduces activity of the renal sympathetic nerves, which is central to blood pressure regulation. It is a minimally invasive procedure that modulates the output of the sympathetic nerves located outside the renal artery walls.§

What is the procedure? The Symplicity renal denervation system accomplishes renal denervation using a system consisting of a proprietary generator and a flexible catheter. The catheter is introduced through the femoral artery in the upper thigh and is threaded up into the renal artery near each kidney. Once in place, the tip of the catheter delivers low-power, radiofrequency (RF) energy according to a proprietary algorithm, or pattern, to modulate the surrounding sympathetic nerves. After energy delivery in mulitple locations along each artery, the Symplicty® catheter is removed—there is no permanent implant.

SIZES GENERATOR

• Dimensions of 29.9 cm × 36.7 cm × 18.9 cm (11.8 in. × 14.5 in. × 7.45 in.) • Weight of 9.1 kg (excluding any accessories) • 10.4 in. (26.4 cm) display screen

PERFORMANCE GENERATOR

• RF power output to a maximum of 8.0 W (for treatment with Symplicity Flex catheter) • Delivers energy if measured impedance is >100 ohms and 100 ohms and 18 years

Not pregnant In-office systolic blood pressure ≥160 mmHg If type 2 diabetes mellitus in-office systolic blood pressure ≥150 mmHg 24hr ABPM ≥135 mmHg Number of antihypertensive drugs, including a diuretic ≥3 (adequate and maximally tolerated doses)

eGFR ≥45 ml/min/1.73 m²

www.medtronicRDN.com

eom creative group

Illustration Infographics

DESIGN MATTERS

TM

CREATIVE GROUP

DESIGN MATTERS

TM

CREATIVE GROUP