TITLE: Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms

« ^- * AD Award Number: DAMD17-96-1-6056 TITLE: Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms PRINCIPAL INVESTIGATOR: Ronald G. Hall...
2 downloads 0 Views 990KB Size
«

^- *

AD

Award Number: DAMD17-96-1-6056

TITLE: Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms

PRINCIPAL INVESTIGATOR:

Ronald G. Haller, M.D.

CONTRACT ING ORGANIZ AT ION: The University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9016

REPORT DATE:

July2000

TYPE OF REPORT: Final

PREPARED FOR:

U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012

DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited

The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

Form Approved OMB No. 074-0188

REPORT DOCUMENTATION PAGE

Public reportinn burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and ' maintaininq the data needed and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this' burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 222024302 and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503

1. AGENCY USE ONLY (Leave blank) 4. TITLE AND SUBTITLE

3. REPORT TYPE AND DATES COVERED

2. REPORT DATE

July 2000

Final (15 Jun 96 -14 Jun 00) 5. FUNDING NUMBERS

Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms

DAMD17-96-1-6056

6. AUTHOR(S) Ronald G. Haller, M.D.

8. PERFORMING ORGANIZATION REPORT NUMBER

7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)

E-Mail:

The University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9016

[email protected] 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)

10. SPONSORING / MONITORING AGENCY REPORT NUMBER

U.S. Army Medical Research and Materiel Command Fort Derrick, Maryland 21702-5012

20011127 050

11. SUPPLEMENTARY NOTES

12b. DISTRIBUTION CODE

12a. DISTRIBUTION / AVAILABILITY STATEMENT

Approved for Public Release; Distribution Unlimited

13. ABSTRACT (Maximum 200 Words) We investigated the basis of symptoms of exertional fatigue in 30 symptomatic and 21 asymptomatic Gulf War (GW)Veterans matched for age, height and weight. Serum CK, incidence of elevated CK, and muscle histology and fatigue rate and level of oxygen uptake relative to 02 delivery during forearm exercise were similar in both groups. In contrast, peak cycle work (126+34 versus 153±43 watts), oxygen utilization (23.5±5.5 vs 27.417.4 ml. kg^min'1) , and cardiac output (173+53 vs 206± 49.kg~1min~1) , and peak blood lactate (6.6±2.3 vs 8.0+2.3 iruM) and potassium (5.5+0.6 vs 6.0+0.7 mM) were lower (p

Suggest Documents