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Award Number: DAMD17-96-1-6056
TITLE: Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms
PRINCIPAL INVESTIGATOR:
Ronald G. Haller, M.D.
CONTRACT ING ORGANIZ AT ION: The University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9016
REPORT DATE:
July2000
TYPE OF REPORT: Final
PREPARED FOR:
U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012
DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited
The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.
Form Approved OMB No. 074-0188
REPORT DOCUMENTATION PAGE
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1. AGENCY USE ONLY (Leave blank) 4. TITLE AND SUBTITLE
3. REPORT TYPE AND DATES COVERED
2. REPORT DATE
July 2000
Final (15 Jun 96 -14 Jun 00) 5. FUNDING NUMBERS
Fatigue in Persian Gulf Syndrome - Physiologic Mechanisms
DAMD17-96-1-6056
6. AUTHOR(S) Ronald G. Haller, M.D.
8. PERFORMING ORGANIZATION REPORT NUMBER
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)
E-Mail:
The University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9016
[email protected] 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)
10. SPONSORING / MONITORING AGENCY REPORT NUMBER
U.S. Army Medical Research and Materiel Command Fort Derrick, Maryland 21702-5012
20011127 050
11. SUPPLEMENTARY NOTES
12b. DISTRIBUTION CODE
12a. DISTRIBUTION / AVAILABILITY STATEMENT
Approved for Public Release; Distribution Unlimited
13. ABSTRACT (Maximum 200 Words) We investigated the basis of symptoms of exertional fatigue in 30 symptomatic and 21 asymptomatic Gulf War (GW)Veterans matched for age, height and weight. Serum CK, incidence of elevated CK, and muscle histology and fatigue rate and level of oxygen uptake relative to 02 delivery during forearm exercise were similar in both groups. In contrast, peak cycle work (126+34 versus 153±43 watts), oxygen utilization (23.5±5.5 vs 27.417.4 ml. kg^min'1) , and cardiac output (173+53 vs 206± 49.kg~1min~1) , and peak blood lactate (6.6±2.3 vs 8.0+2.3 iruM) and potassium (5.5+0.6 vs 6.0+0.7 mM) were lower (p