Timo Siepmann, M.D. Biographical sketch Oxford Cardiovascular Clinical Research Facility, University of Oxford [email protected]

Principles and Practice of Clinical Research, Harvard Medical School [email protected]

Department of Neurology, Carl Gustav Carus University Hospital [email protected]

As a clinical neuroscientist at the University of Oxford I am dedicated to patient care and advancing neuroscience with a focus on the development of novel techniques to diagnose and treat disorders of the autonomic nervous system. Motivating my work is a passion for discovery and international collaboration in research to elucidate new insights in science and connect neuroscience with complementary disciplines in an international collaborative approach. As program director of the Master’s Program of Clinical Research at Dresden International University and local site director of Harvard’s Principles and Practice of Clinical Research it is my goal is to translate insights from research into practice at health care institutions around the globe in order to improve patient care and build bridges between scientists of different countries and cultures.

_______________________________________________________________________________________________ Academic and clinical appointments 2015 – present

University of Oxford John Radcliffe Hospital Postdoctoral Researcher Visiting Scholar funded by the European Academy of Neurology Cardiovascular Clinical Research Facility Radcliffe Department of Medicine Oxford, Oxfordshire, United Kingdom

2011-2015

Dresden University of Technology Carl Gustav Carus Hospital Clinical research physician, Instructor in clinical pharmacology Department of Neurology, Institute of Clinical Pharmacology Dresden, Saxony, Germany

2010-2011

Harvard Medical School Beth Israel Deaconess Medical Center Clinical research fellow Center for Autonomic and Peripheral Nerve Disorders Boston, MA, United States

2009-2011

University of Rostock MediClin Klinikum- Rostock Medical Faculty Teaching Hospital Resident and director of the Laboratory for Autonomic Functions and Biofeedback Department of Neurology Plau, Western Pomerania, Germany

_______________________________________________________________________________________________ Scientific leadership positions 2014-present

Dresden International University Program director Master’s Program in Clinical Research (M.Sc.) Dresden, Saxony, Germany

2012-present

Harvard Medical School Local site director Site Centers Dresden and Berlin Principles and Practice of Clinical Research Spaulding Rehabilitation Hospital and Massachusetts General Hospital Boston, MA, United States

2009-2012

Medical Council Mecklenburg-Vorpommern Course director Academia neurologica (CME) Plau, Western Pommerania, Germany

_______________________________________________________________________________________________ Education and doctoral thesis 2014

New England Journal of Medicine NEJM Manuscript Review CME Program Massachusetts Medical Society Boston, MA, United States

2008

Dresden University of Technology Doctoral thesis: The effects of venlafaxine on autonomic and cognitive functions, magna cum laude Institute of Clinical Pharmacology Dresden, Saxony, Germany

2002-2008

Charité University Medicine Medical School Berlin, Germany

_______________________________________________________________________________________________ Awards 2015

Dresden International University Award Academic leadership award

2014

Federation of European Physiological Societies Investigator Award Research award

2013

International Society for Autonomic Neuroscience and European Federation of Autonomic Societies Travel award

2012

American Academy of Neurology International scholarship Award Research award

2011

International Society for Autonomic Neuroscience and American Autonomic Society Award Travel award

2011

American Academy of Neurology International Scholarship Award Research award

2010

Research award of the German Society of Clinical Pharmacology Rudolf-Buchheim-Preis

2010

American Autonomic Society Fellowship Award Research and travel award

2009

Medical Faculty Carl Gustav Carus Award Faculty award for outstanding dissertation

_______________________________________________________________________________________________ Grants 2015

Michael J. Fox Foundation Research grant (principle investigator)

2015

Prothena Biosciences Research grant (principle investigator)

2014

European Academy of Neurology Research grant (visiting scholar)

2013

Prothena Biosciences Research grant (principle investigator)

2010-2011

German Research Foundation Research grant (visiting scholar)

_______________________________________________________________________________________________ Teaching 2014- present

Dresden International University Lecturer Master’s Program in Clinical Research and Master’s Program in Physiotherapy Over 60 hours teaching per year including lectures on    

2013-present

Neurological Emergencies Economic Aspects of Clinical Research Clinical Pharmacological Trials Scientific Presentation

Medical School Carl Gustav Carus Lecturer, seminar facilitator  

Autonomic Disorders in the Elderly (geriatrics main course lecture) Antibiotics (clinical pharmacology main seminar)



Clinical Neurology (practical bedside seminar)

_______________________________________________________________________________________________ Mentoring 2010-2011

Harvard Medical School Beth Israel Deaconess Medical Center, supervision of summer intern Joseph Roofeh (paper in Nutrition)

2014-present

Dresden International University Division of Health Care Sciences, thesis supervision of over 30 students of the Master’s Program in Clinical Research (M.Sc.)

2013-2014

Technische Universität Dresden Medical Faculty, Neurology, thesis supervision of 4 medical doctoral candidates (Dr. med.)

_______________________________________________________________________________________________ Review and advisory panels 2014-present

New England Journal of Medicine Peer reviewer

2013-present

Neuropsychiatric Disease and Treatment Editorial Board

2012-present

Journal of Contemporary Medical Education Associate Editor

2012-present

American Journal of Pharmacological Sciences Editorial Board

2012

American Academy of Neurology Abstract Reviewer, AAN-autonomic disorders section, 64th Annual Meeting

2012-present

Research journals Peer reviewer for the following journals:          

PLOS ONE BMJ Case Reports Parkinson’s disease Nutrition and Dietary Supplements Degenerative Neurological and Neuromuscular Disease Journal of Clinical Immunology Autonomic Neuroscience: Basic and Clinical Journal of Public Health Journal of Surgery Deutsche Medizinische Wochenschrift

_______________________________________________________________________________________________ Professional societies 2013-present

German Neurological Society (DGN)

2012-present

Harvard University Alumni Club of Berlin

2010-present

German Society of Clinical Pharmacology (DGPT)

_______________________________________________________________________________________________ Community services 2006-2013

Charité University Medicine Berlin Student Council Co-Chairman, Actions – No Words, Germany

2015

World Doctors Orchestra Charity Concert 2015 Dresden Board member of the local organizing committee

_______________________________________________________________________________________________ Publications Over 75 papers and conference publications in international journals. Selected papers: Siepmann T, Penzlin AI, Kepplinger J, Illigens BM, Weidner K, Reichmann H, Barlinn K. Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence. Brain Behav. 2015 Sep 23;5(10):e00373. Penzlin AI, Siepmann T, Illigens BM, Weidner K, Siepmann M. Heart rate variability biofeedback in patients with alcohol dependence: a randomized controlled study. Neuropsychiatr Dis Treat. 2015 Oct 9;11:2619-27. doi: 10.2147/NDT.S84798. eCollection 2015. Nassir M, Guan J, Luketina H, Siepmann T, Rohr I, Richter R, Castillo-Tong DC, Zeillinger R, Vergote I, Van Nieuwenhuysen E, Concin N, Marth C, Hall C, Mahner S, Woelber L, Sehouli J, Braicu EI. The role of HE4 for prediction of recurrence in epithelial ovarian cancer patients-results from the OVCAD study. Tumour Biol 2015 [Epub ahead of print] Pintér A, Cseh D, Sárközi A, Illigens BM, Siepmann T. Autonomic Dysregulation in Multiple Sclerosis. Int J Mol Sci 2015;16:16920-16952 Seidlitz A, Siepmann T, Löck S, Juratli T, Baumann M, Krause M. Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme. Radiat Oncol 2015:10:172 Woopen H, Richter R, Chekerov R, Siepmann T, Ismaeel F, Sehouli J.The influence of comorbidity and comedication on grade III/IV toxicity and prior discontinuation of chemotherapy in recurrent ovarian cancer patients: An individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO). Gynecol Oncol 2015;138:735-740 Siepmann T, Kepplinger J, Zerna C, Schatz U, Penzlin AI, Pallesen LP, Illigens BM, Weidner K, Reichmann H, Puetz V, Bodechtel U, Barlinn K. The effects of pretreatment versus de novo treatment with selective serotonin reuptake inhibitors on short-term outcome after acute ischemic stroke. J Stroke Cerebrovasc Dis 2015;24:1886-1892 Zerna C, Siepmann T, Barlinn K, Kepplinger J, Pallesen LP, Puetz V, Bodechtel U. Association of time on outcome after intravenous thrombolysis in the elderly in a telestroke network. J Telemed Telecare 2015, pii: 1357633X15585241. [Epub ahead of print] Kepplinger J, Prakapenia A, Barlinn K, Siegert G, Gehrisch S, Zerna C, Beyer-Westendorf J, Puetz V, Reichmann H, Siepmann T, Bodechtel U. Standardized use of novel oral anticoagulants plasma level thresholds in a new thrombolysis decision making protocol. J Thromb Thrombolysis 2015. [Epub ahead of print] Schatz U, Illigens BM, Siepmann T, Arneth B, Siegert G, Siegels D, Heigl F, Hettich R, Ramlow W, Prophet H, Bornstein SR, Julius U. TIDILAP: Treatment of iron deficiency in lipoprotein apheresis patients - A prospective observational multi-center cohort study comparing efficacy, safety and tolerability of ferric gluconate with ferric carboxymaltose. Atheroscler Suppl 2015;18:199-208

Penzlin AI, Siepmann T, Illigens BM, Weidner K, Siepmann M. Heart rate variability biofeedback in alcohol addicted patients: a randomized controlled study Neuropsychiatr Dis Treat, accepted for publication Zerna C, von Kummer R, Gerber J, Engellandt K, Abramyuk A, Wojciechowski C, Barlinn K, Kepplinger J, Pallesen LP, Siepmann T, Dzialowski I, Reichmann H, Puetz V, Bodechtel U. Telemedical Brain Computed Tomography Misinterpretation by Stroke Neurologists Is Not Associated with Thrombolysis-Related Intracranial Hemorrhage. J Stroke Cerebrovasc Dis 2015; doi: 10.1016/j.jstrokecerebrovasdis.2015.03.022, Epub ahead of print Zerna C, Siepmann T, Barlinn K, Kepplinger J, Pallesen LP, Puetz V, Bodechtel U. Association of time on outcome after intravenous thrombolysis in the elderly in a telestroke network. J Telemed Telecare, J Telemed Telecare. 2015 May 29. pii: 1357633X15585241. [Epub ahead of print] Barlinn K, Kepplinger J, Puetz V, Illigens BM, Bodechtel U, Siepmann T. Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis. Neuropsychiatr Dis Treat. 2015,11:1-14 Barlinn K, Kolieskova S, Bavarsad Shahripour R, Kepplinger J, Boehme AK, Siepmann T, Puetz V, Bodechtel U, Jordan WD, Alexandrov AV. Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients. J Stroke Cerebrovasc Dis 2015;24:189-195 Lohkamp L, Öllinger R, Chatzigeorgiou A, Illigens BM, Siepmann T. Intraoperative biomarkers in renal transplantation. Nephrology (Carlton). 2015 Jul 1. doi: 10.1111/nep.12556. [Epub ahead of print] Siepmann T, Heinke D, Kepplinger J, Barlinn K, Gehrisch S, Grählert X, Schwanebeck U, Reichmann H, Puetz V, Bodechtel U, Gahn G. Interaction of clopidogrel and statins in secondary prevention after cerebral ischemia – a randomized, double-blind, double-dummy crossover-study. Br J Clin Pharmacol 2014; 78:10581066 Siepmann T, Bodechtel U. Teaching NeuroImages: macaroni sign. Neurology. 2014 Jul 1;83:e11 Siepmann T, Illigens BM, Reichmann H, Ziemssen T, Axon-reflex based nerve fiber function assessment in the detection of autonomic neuropathy. Nervenarzt 2014; 85:1309-1314 Siepmann M, Hennig UD, Siepmann T, Nitzsche K, Mück-Weymann M, Petrowski K, Weidner K. The Effects of Heart Rate Variability Biofeedback in Patients with Preterm Labour. Appl Psychophysiol Biofeedback 2014; Mar;39:27-35 Siepmann T. Statins for primary prevention: are the guidelines in need of improvement? - Preventive pharmacotherapy: indication has to be adapted individually. Dtsch Med Wochenschr 2014;139:1284 Illigens BM*, Siepmann T*, Roofeh J, Gibbons C. Laser-Doppler Imaging in the Detection of Peripheral Neuropathy. Auton Neurosci 2013;177:286-290 * authors contributed equally Siepmann T, Tesch M, Krause F, Illigens BM, Stoltenburg-Didinger G. Polymyositis with cytochrome C oxidase negative fibers - a pathological and clinical challenge. Ann Diagn Pathol 2013;17:183-186 Goltz L, Bodechtel U, Siepmann T. Statins and ASA for primary prevention of cardiovascular and cerebrovascular disease. Dtsch Med Wochenschr 2013;139:283-286 Siepmann T, Penzlin AI, Illigens BMW. Autonomic neuropathy – diagnosis and evidence based treatment. Dtsch Med Wochenschr 2013 ;138:1529-1532 Siepmann T, Penzlin AI, Illigens BMW. Autonomic neuropathies. Dtsch Med Wochenschr 2013;138:14651469 Siepmann T, Gibbons C, Lafo J, Brown C, Freeman R. Quantitative Pilomotor Axon-Reflex Test – A Novel Test of Pilomotor Function. Arch Neurol 2012;6:1-5

Siepmann T, Roofeh J, Kiefer FW, Edelson DG. Hypogonadism and Erectile Dysfunction Associated With Soy Product Consumption. Nutrition 2011;27:859-862 Lindauer A, Siepmann T, Oertel R, Jung A, Ziemssen T, Jaehde U, Kirch W, Siepmann M. Pharmacokinetic/pharmacodynamic modeling of venlafaxine: pupillary light reflex as test system for noradrenergic effects. Clin Pharmacokinet 2008;47:721-731 Siepmann T, Mück-Weymann M, Oertel, R, Pittrow D, Kirch W, Siepmann M. The effects of venlafaxine on cognitive functions and quantitative EEG in healthy volunteers. Pharmacopsychiatry 2008;41:146-150 Siepmann T, Ziemssen T, Mueck-Weymann M, Kirch W, Siepmann M. The effects of venlafaxine on autonomic functions in healthy volunteers. J Clin Psychopharm 2007;27:687-691 Siepmann T, Penzlin AI, Kepplinger J, Illigens BM, Weidner K, Reichmann H, Barlinn K. Selective Serotonin Reuptake Inhibitors to Improve Outcome in Acute Ischemic Stroke: Possible Mechanisms and Clinical Evidence. Brain Behav 2015 Sep 23;5(10):e00373.

_______________________________________________________________________________________________ Textbooks 1.

Siepmann T, Kirch W, Kullak-Ublick GA (Editors). Arzneimitteltherapie (Drug therapy), 2nd edition. Thieme,Stuttgart, in press

2.

Kullak-Ublick GA, Siepmann T, Kirch W (Editors). Arzneimitteltherapie (Drug therapy), 1st edition. Thieme, Stuttgart, 2012