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The Indian Journal of Pediatrics November 2007; Volume 74 : Number 11
CONTENTS Page ORIGINAL ARTICLES Newly Developed WHO Growth Standards : Implications for Demographic Surveys and Child Health Programs P.R. Deshmukh, A.R. Dongre, S.S. Gupta and B.S. Garg
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Growth Hormone in Intra-Uterine Growth Retarded Newborns S. Setia, M.G. Sridhar, V. Bhat and Latha Chaturvedula
Spectrum of Severe Skeletal Dysplasias in North India Ratna D. Puri, Seema Thakur and I.C. Verma
Effect of Clofibrate in Non-hemolytic Indirect Hyperbilirubinemia in Full Term Neonates Fatemeh Eghbalian, Abolfazl Pourhossein and Hassan Zandevakili
Essential Hypertension in Early and Mid-Adolescence M.R. Savitha, B. Krishnamurthy, Sudhindra Shayana R Fatthepur, Yashwanth Kumar A.M. and Mudassir Azeez Khan1
Pattern of Tobacco Use Among School Children in National Capital Territory (NCT) Vinita Singh, Hem Raj Pal, Manju Mehta, S.N. Dwivedi and Umesh Kapil
Association of HLA-B*08:DRB1*03 with Immunoglobulin A-deficiency Agnieszka Czyzewska-Buczyñska, Grazyna Majkowska-Skrobek and Adam Jankowski
Ionized Magnesium and Gestational Age Rajeev Mehta and Anna Petrova
CLINICAL BRIEFS Short Rib Polydactyly Syndrome – Type 2 (Majewski) Vrinda Nair, K.L. Prakash and B. Vishnu Bhat
Intravenous Immunoglobulin Therapy of Lupus Pneumonitis G. Chetan, S. Mahadevan, Kikon Sulanthung and P. Narayanan
Multiple Cavernous Malformations with Supravermian Arachnoid Cyst Aycan Unalp and Nedret Uran
Transient Methemoglobinemia in an Infant R. Venkateswari, R. Ganesh, M. Deenadayalan, E. Mahender, Bala Ramachandran and Lalitha Janakiraman
Unilateral Palatal Palsy with Viral Hepatitis P.L. Prasad, A.N. Prasad and S.K. Patnaik
Fatal Thyrotoxic Periodic Paralysis With Normokalemia Nitin Satam, Vaishali More, Preeti Shanbag and Alka Kalgutkar Indian Journal of Pediatrics, Volume 74—November, 2007
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Page Hypomelanosis of Ito with Cerebral Malformation Mary Iype, Thomas Iype, S. Geetha and John Retnakumar
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GUIDELINES FOR AUTHORS
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NOTES AND NEWS
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Idiopathic Chronic Subdural Hematoma, MCA Infarct and Cortical Atrophy with Status Epilepticus in Infants – Report of two Cases Raj Kumar, Namit Singhal and A.K. Mahapatra
LETTER TO THE EDITOR Kawasaki Disease with DIC as a Complication V.K. Parvathy, A. Davis Manuel, S. Criton, G. Rajesh
Hemorrhagic Pleural Effusion : Can it be Scurvy? Jyoti Suvarna, Parag M. Tamhankar and C.T. Deshmukh
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Original Article
Association of HLA-B*08:DRB1*03 with Immunoglobulin A-deficiency Agnieszka Czyzewska-Buczyñska1, Grazyna Majkowska-Skrobek2 and Adam Jankowski1,2 1
Department of Pediatric Propedeutics, Division of Children’s Immunology and Rheumatology, Medical University of Wroclaw, Wroclaw, Poland, 2Immunology Unit, Department of General Microbiology, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland
ABSTRACT Objective. Susceptibility to IgA deficiency (IgAD) is strongly associated with alleles of HLA, but it is not equally strong in different human populations. Therefore, the goal of this study was to determine the HLA-A, -B and -DRB1 antigenic and haplotypic frequencies in unrelated Polish Caucasian IgA-deficient patients who had never been examined so far in this respect. Methods. The HLA alleles were determined by means of low resolution polymerase chain reaction with sequence specific primers (PCR-SSP) method in a group of IgA-deficient patients and control subjects from the same area. Results. The HLA-DRB1*03 allele showed the strongest association with IgA deficiency in the Polish population (OR=6.6, pcor=0.0084). The HLA-B*08 allele was also associated with predisposition to the disease (OR=6.22, pcor=0.033). These significant associations could be explained in the context of a positive association of IgAD with the HLA-B*08:DRB1*03 haplotype, previously reported in other Caucasoid populations from Northern and Central Europe. In our group the HLAB*08:DRB1*03 haplotype was present in 52.9% of IgA-deficient patients comparing to 9.9% in controls (p
