Gross-Tsur et al. Reproductive Biology and Endocrinology 2012, 10:39 http://www.rbej.com/10/1/39
RESEARCH
Open Access
The FSH-inhibin axis in prader-willi syndrome: heterogeneity of gonadal dysfunction Varda Gross-Tsur1,2,3†, Harry J Hirsch1†, Fortu Benarroch4 and Talia Eldar-Geva1,3,5*†
Abstract Background: We characterized the spectrum and etiology of hypogonadism in a cohort of Prader-Willi syndrome (PWS) adolescents and adults. Methods: Reproductive hormonal profiles and physical examination were performed on 19 males and 16 females ages 16–34 years with PWS. Gonadotropins, sex-steroids, inhibin B (INB) and anti-Mullerian hormone (AMH) were measured. We defined 4 groups according to the relative contribution of central and gonadal dysfunction based on FSH and INB levels: Group A: primary hypogonadism (FSH >15 IU/l and undetectable INB (
