The Addicted Brain and New Treatment Frontiers Sixth Annual Aspen Brain Forum

May 18 – 20, 2016 · New York City The New York Academy of Sciences Conference Center

Presented by the Aspen Brain Forum Foundation, Science Translational Medicine, and the New York Academy of Sciences

Background and Significance Substance and alcohol-use disorders — characterized by continued, compulsive, stimulus-seeking behaviors despite serious negative physical, emotional, and social consequences — impose significant human health, economic, and legal burdens on society. Although research suggests that addiction is strongly related to neurobiological changes in the brain, implementation of neuroscience-based therapeutic strategies to address addiction is a relatively nascent development. As such, patients in need of treatment for addiction may not be receiving short- and long-term care that considers neurobiological, molecular, and/or genetic aspects of addiction. The Aspen Brain Forum Foundation, Science Translational Medicine, and the New York Academy of Sciences have organized a conference to address these important issues entitled, The Addicted Brain and New Treatment Frontiers. The conference will be presented at the New York Academy of Sciences Conference Center on May 18 – 20, 2016. This 2.5-day landmark event will have an important impact on our understanding of the molecular mechanisms involved in addiction and novel treatment strategies. This conference agenda was developed in close collaboration with expert scientific leadership from the U.S. National Institute on Drug Abuse (NIDA), the U.S. National Institute on Alcohol Abuse and Alcoholism (NIAAA) and an international group of leading scientists and physicians from treatment research centers and academic medical research institutions. The program will convene up to 300 participants from academic institutions, treatment centers, pharmaceutical companies, government agencies, and non-profit organizations. The aim is to better understand, prevent, and treat addiction. The organizers seek to enhance the recruitment and retention of early career and underrepresented minority investigators to this multidisciplinary area of research.

Major Scientific Themes The conference will explore the following topics:

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Mechanisms of Neuroplasticity in Addiction

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Adolescent Brain Development and Susceptibility in Addiction

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Transcriptional and Epigenetic Mechanisms in Addiction

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New Horizons for Treatment Strategies

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Social, Economic, Political, and Legal Facets of Addiction

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Presenting Partners The planning and execution of The Addicted Brain and New Treatment Frontiers is a collaborative partnership among the Aspen Brain Forum Foundation, the journal Science Translational Medicine, and The New York Academy of Sciences. Please see below for further details about each presenting partner organization.

The Aspen Brain Forum Foundation convened its first annual meeting in 2010 focused on Neurotechnology: Building Better Brains. As a 501(c)(3) non-profit organization, the Aspen Brain Forum Foundation supports and produces scientific meetings covering topics ranging from neuroprosthetics to the developing human brain. The Foundation’s mission is to:  Organize, produce, and host an annual high-level meeting of international brain researchers, with our partner, the New York Academy of Sciences, leading to global collaborations and breakthroughs in world brain science.  Present and disseminate the most cutting-edge innovations in brain science.  Ally with large new initiatives, such as the American Brain Coalition, the American Brain Foundation, and One Mind for Research, to prevent and cure brain disorders such as Alzheimer’s, Parkinson’s, autism, and depression, within a decade. Science Translational Medicine was launched in 2009 and publishes 12 – 16 peer-reviewed, full-length, original research articles per month. The goal of Science Translational Medicine is to promote human health by providing a forum for communicating the latest biomedical research findings from basic, translational, and clinical researchers from all established and emerging disciplines relevant to medicine. Despite 50 years of advances in our fundamental understanding of human biology and the emergence of powerful new technologies, the translation of this knowledge into effective new treatments and health measures has been slow. Science Translational Medicine seeks to publish articles that identify and fill the scientific knowledge gaps at the junction of basic research and medical application in order to accelerate the translation of this knowledge into new ways for preventing, diagnosing and treating human disease. To learn more about Science Translational Medicine, please visit stm.sciencemag.org. Founded in 1817, The New York Academy of Sciences is one of the oldest scientific institutions in the United States. The Academy is an independent 501(c)(3) nonprofit, scientific, and educational organization with a history of fostering new collaborations among key stakeholders and emerging experts in academia, industry, and government in order to drive advances in science, medicine, technology, innovation, and sustainability. Through our diverse portfolio of interdisciplinary scientific conferences and seminars, career development and public outreach programs, and global dissemination of the latest scientific breakthroughs via innovative print and electronic media, we engage an informed and diverse membership community that encompasses more than 20,000 individuals in 100 countries. To learn more, please visit www.nyas.org.

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Convening the World’s Leading Experts Scientific Organizing Committee           

Melanie Brickman Stynes, MSc, PhD, Director, Life Sciences Conferences, The New York Academy of Sciences Joseph Dial, Chairman, Scientific Advisory Board, The Aspen Brain Forum Foundation David R. Gastfriend, MD, Senior Advisor, The Treatment Research Institute Staci Gruber, PhD, Director, Marijuana Investigations for Neuroscientific Discovery (MIND), McLean Hospital, Harvard Medical School Peter W. Kalivas, PhD, Professor and Chair of Neuroscience, Medical University of South Carolina Katrina Kelner, PhD, Editor, Science Translational Medicine George F. Koob, PhD, Director, National Institute on Alcoholism and Alcohol Abuse, U.S. National Institutes of Health Orla M. Smith, PhD, Managing Editor, Science Translational Medicine Erick Tatro, PhD, Program Manager, Life Sciences, The New York Academy of Sciences Rachel F. Tyndale, PhD, Professor of Pharmacology, Toxicology, and Psychiatry, Endowed Chair in Addictions, University of Toronto Nora D. Volkow, MD, Director, National Institute on Drug Abuse, U.S. National Institutes of Health

Confirmed Speakers                

Michael R. Bruchas, PhD, Associate Professor of Anesthesiology and Neurobiology, Washington University School of Medicine Meaghan Creed, PhD, Post-doctoral Scholar, Center for Addiction and Mental Health, University of Geneva Ronald G. Crystal, MD, Chair, Department of Genetic Medicine, Weill Cornell Medical College Thomas Eissenberg, PhD, Professor of Health Psychology, Co-director, Center for the Study of Tobacco Products, a World Health Organization Collaborating Centre, Virginia Commonwealth University Barry J. Everitt, ScD, Emeritus Professor of Behavioural Neuroscience, Department of Psychology, University of Cambridge Diana Fishbein, PhD, C. Eugene Bennett Chair in Prevention Research, Pennsylvania State University Yasmin Hurd, PhD, Ward-Coleman Chair of Translational Neuroscience, Director, Center for Addictive Disorders, Icahn School of Medicine at Mount Sinai Hospital Thomas Kash, PhD, Assistant Professor of Department of Pharmacology, University of North Carolina School of Medicine Honorable Patrick J. Kennedy, Former U.S. Representative, Rhode Island; One Mind for Research; and Kennedy Forum Mark Kleiman, MPP, PhD, Professor Emeritus of Public Policy, University of California Los Angeles David Lovinger, PhD, Chief, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health Thomas McLellan, MD, PhD, Professor of Psychiatry, Director, Penn Center for Substance Abuse Solutions, University of Pennsylvania Read Montague, PhD, Director, Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute Eric J. Nestler, PhD, MD, Chair of Neuroscience, Director, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai Hospital Susan F. Tapert, PhD, Professor of Psychiatry, University of California San Diego Susan R. B. Weiss, PhD, Director, Division of Extramural Research, National Institute on Drug Abuse, U.S. National Institutes of Health

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Broad Conference Goals 

Facilitate a neutral, scientific, knowledge exchange to explore the latest in advances in neurobiology research in order to utilize new knowledge to improve therapeutic approaches for treating addiction.

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Promote dissemination and successful translation of new knowledge regarding the mechanisms of neuroplasticity in addiction, adolescent brain development and susceptibility in addiction, and new horizons for treatment strategies.

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Summarize the state of the science and the potential of new therapies including optogenetically-inspired deep brain stimulation, pharmacogenetics, immune-based modalities, behavioral interventions, and novel pharmaceuticals in the treatment of addiction.

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Foster new and lasting cross-disciplinary partnerships and collaborations between researchers in disparate biomedical and health science fields — such as genetics, neuroscience, pharmacology, psychiatry, public health — in order to improve the knowledge sharing, with the goal of promoting the identification and deployment of new treatment strategies for addiction.

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Attract, showcase, and maintain new, early career, and underrepresented investigators (including women, ethnic/racial minorities, and persons with disabilities) to this multidisciplinary area of research.

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Facilitate a robust dialogue among participants through interactive networking and meal breaks, a career mentoring workshop, a networking reception, and distribution of participant contact information to all registrants prior to and during the conference.

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Host two interactive poster sessions; award early career investigator / minority travel fellowships; and invite four oral “Hot Topics” presentations as selected from submitted abstracts based on scientific merit.

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Publish and promote conference proceedings in Annals of the New York Academy of Sciences.

Projected Conference Outcomes 

Enhanced communication and collaboration among both junior- and senior-level international researchers (from academia, government, and industry) and clinicians along with other interested stakeholders to promote the exchange of ideas, results, and technologies leading to successful translation into the treatment of addiction.

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Dissemination of knowledge and data exchanged by conference participants beyond the audience of the live event, thus maximizing the impact for the growing addiction research community.

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Conference Format The conference will feature a series of Keynote Addresses, including an address by Nora D. Volkow, MD, (pictured, left), Director of the National Institute on Drug Abuse, U.S. National Institutes of Health, and a pioneer in the field of neurobiology of addiction. Dr. Volkow will provide an overview of the significance of the disease of addiction to brain development, function, and behavior. George F. Koob, PhD (pictured, right) Director of the National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health who first discovered the altered state of stress and mood pathways in the brain during substance abuse, will provide a second keynote address and discuss alcohol abuse and the stress system. Each plenary session will focus on a specific aspect underlying addiction as a disorder of the brain. The Scientific Organizing Committee identified the most important open questions and challenges that, when addressed, will aid in solving the societal problem of addiction. The conference opens with an evening Public Lecture on Day 1 designed to inspire and inform a lay-audience on the biological risks and social consequences of substance abuse on the developing teenage brain. The format of the Public Lecture is a moderated panel discussion, which will be followed by a networking reception. This distinctive format will create a lively conversation among panelists, engage attendees in discussions, and inspire the best ways to move research forward. Scientific sessions on Day 2 will explore advances in understanding the neurocircuitry of addiction and lectures that examine the susceptibility to- and effect of- substance abuse on the developing adolescent brain. On Day 3, speakers will explore the applications of the knowledge discussed in the prior sessions as new horizons for treatment strategies. The conference will close with a call to action featuring lectures on implementing knowledge of neuroscience of addiction to improve public policy and action.

Early Career Investigator and Underrepresented Minority Participation Aspen Brain Forum Foundation, Science Translational Medicine, and the New York Academy of Sciences seek to attract the participation of Early Career Investigators and underrepresented minorities by providing Travel Fellowships, poster sessions with prizes, a career development workshop, and short presentations selected from submitted abstracts (“Hot Topic” presentations). Travel Fellowships — NYAS will issue a call for applications and award a number of travel fellowships (up to $750 each) for early career investigators. The committee will select graduate students, postdoctoral researchers, and early career faculty who have shown a commitment to addiction research, via a competitive application process, including submission of letters of recommendation and a poster abstract. Travel Fellowships (up to $750 each) for Underrepresented Minority Investigators will also be awarded. Poster Sessions — Participating scientists are invited to submit poster abstracts for presentation at two dedicated conference Poster Sessions, allowing poster presenters and attendees to exchange knowledge, interact, and establish new connections and collaborations. The compiled poster abstracts will be archived on the conference website and made available to the global scientific community. Career Development Workshop — The summit will offer a dedicated presentation for young investigators titled “Editor's Guide to Writing and Publishing Your Paper,” led by the former Science Editor of The Journal of Clinical Investigation. Short Oral Presentations — Four investigators will be selected from the pool of submitted poster abstracts for podium “Hot Topic” talks. Presenters will be selected from submitted abstracts by the scientific organizing committee in a competitive process open to all investigators in the field, with preference given to early career investigators.

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Open-Access, Web-Based Enduring Materials Enduring information presented at the summit will be freely retrievable and widely disseminated to reach thousands of virtual participants beyond the walls of the conference center.

Multimedia eBriefings Academy eBriefings are web-based, multimedia overviews of our events which are hosted at www.nyas.org/ebriefings. The Academy’s online library of more than 500 eBriefings receives over 10,000 visitors every month. eBriefings are consistently rated among the most popular and most frequently visited features on the Academy website. eBriefings include:  A succinct, easy-to-read summary of the conference, prepared by a science writer. 

Selections of speakers’ slides synchronized with audio recordings of their talks.

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Additional information including speakers’ abstracts and links to related websites, articles in the scientific literature, and background on the conference speakers.

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Valuable access to information to interested individuals who were unable to attend.

Meeting Report in Annals of the New York Academy of Sciences Annals of the New York Academy of Sciences is one of the oldest scientific serial publications in the United States and among the most cited of multidisciplinary scientific serials worldwide. Continually published since 1823, Annals is the premier publication of the Academy, offering review articles in special topical areas and proceedings of conferences sponsored by the Academy as well as other scientific organizations. Although primarily focused in biomedicine and biology, the scope of Annals extends into diverse fields such as psychology, anthropology, and philosophy. Edited in consultation with experts in their fields, the Annals provide a neutral forum for discourse across many disciplines. Other important facts about Annals of the New York Academy of Sciences:  Members of the New York Academy of Sciences are entitled to free online access to all Annals, one free print Annals volume each year, and discounts on additional print volumes. 

Full text of the Annals is published online by Wiley Blackwell. Annals is also accessible from subscribing institutions and to others on a pay-per-view basis; tables of contents and abstracts are available to anyone.

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Many Annals Meeting Reports are open-access, available online to the general public free of charge, and all online Annals issues are Section 508-compliant.

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Annals volumes are abstracted and/or indexed in all major abstracting and indexing services, including PubMed and Thomson Scientific.

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Thomson Scientific ranks the Annals among the most highly cited sources among the general science literature.

Annals of the New York Academy of Sciences will commission contributions from a selection of conference organizers and speakers, thereby capturing the highlights of the conference in an open-access, online Meeting Report.

Faculty of 1000 Posters After the conclusion the conference, the Aspen Brain Forum Foundation, Science Translational Medicine, and the New York Academy of Sciences will invite outstanding researchers to make their poster presentations available to a global audience via Faculty of 1000’s “F1000 Posters” open-access poster repository. This site provides a permanent, structured environment for the deposition of NYAS conference posters in biology and medicine, as well as a trustworthy venue for ongoing discussion and development of the information being presented. Conference participants who choose to use F1000 Posters can maximize the value of their poster by dramatically increasing access (top performing posters receive 800+ views in a month) and by receiving further online feedback from fellow scientists, expert faculty, publishers, and editors. Please visit http://f1000.com/Posters/NYAS to view examples of posters submitted from recent Academy conferences.

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Benefits – Reaching Thousands All Over the World Why Support? As a sponsor of this conference, you will have exclusive access to scientists from academia, government, and industry in search of the latest advancements and information about the neurobiology of addiction and novel treatments. Supporter benefits include: 

Extensive visibility to a highly targeted, expert audience via the conference’s promotional campaign, on-site exposure during the event, press and media coverage, and post-event information dissemination.

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Unique one-on-one networking opportunities during the event. Exhibiting opportunities and complimentary passes to the event.

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Pre-Event Marketing As a conference supporter, your organization will receive extensive exposure, enabling you to reach out to thousands of targeted researchers, clinicians, patients, and scientists. These channels include targeted print and email campaigns, as well as web advertising. Your support delivers to you: 

Branding as a supporter on the event website, to which traffic is driven by: - Banner ads strategically positioned on the homepage of the Academy. - Traffic from the Academy website, which receives more than 40,000 unique visitors monthly. - Conference advertisements placed in Academy e-Newsletters delivered to more than 74,000 opt-in subscribers. - Electronic advertising posted on several calendars, which will link to the event website.

Onsite Benefits You will benefit as a supporter from many on-site marketing and networking opportunities at the event, including:    

Leading Scientific, Medical, and Pharmaceutical Organizations Support Academy Conferences Select supporters include:  Alzheimer’s Association  Amgen  AstraZeneca International  Bristol-Myers Squibb  Burroughs Wellcome Fund  Canon  Centrum  Eisai  Eli Lilly and Company  European Science Foundation  Genzyme Corporation  Gilead  GlaxoSmithKline  Johns Hopkins University  Johnson & Johnson  Life Technologies  Medical Research Council  Merck & Co., Inc.  U.S. National Institutes of Health  U.S. National Science Foundation  Novartis  Novo Nordisk  Oral Health America  Ortho-McNeil-Janssen  Oxford University  Pepsi  Pfizer  Procter & Gamble  Roche  Sanofi-Aventis  Siemens  Skanska  Solvay Pharmaceuticals  Takeda Pharmaceuticals  Talecris Biotherapeutics  The Gatsby Charitable Foundation  U.S. Army, and more

Branding for your organization via on-site signage throughout the conference. Highlighted position in the conference program distributed to all attendees. Promotion option to display marketing materials such as pamphlets, flyers, postcards, and other materials on the marketing table (subject to approval). Complimentary passes to the event to increase your networking opportunities with attendees (quantity of complimentary passes dependent on level of support). Sponsorship Opportunities — The Addicted Brain & New Treatment Frontiers: 6th Aspen Brain Forum │8

Conference Sponsorship Opportunities Platinum $75,000 and up       

Prominent recognition as a Platinum Sponsor with your logo and organization’s name displayed on the conference website, flyers, and on-site program. Option to sponsor (1) Networking Reception or (1) Lunch. On-site signage throughout the conference. Full-page advertisement in the on-site program (artwork subject to NYAS approval). Complimentary exhibitor table in a high-traffic area. 15 – 20 complimentary registrations (based on level of support). 15+ complimentary, 1-year individual Memberships to NYAS (based on level of support).

Gold $50,000 – $74,999       

Prominent recognition as a Gold Sponsor with your logo and organization’s name displayed on the conference website, flyers, and on-site program. Option to sponsor (1) Continental Breakfast or Conference Lanyards. On-site signage throughout the conference. Full-page advertisement in the on-site program (artwork subject to NYAS approval). Complimentary exhibitor table in a high-traffic area. 10 – 15 complimentary registrations (based on level of support). 10 – 15 complimentary, 1-year individual Memberships to NYAS (based on level of support).

Silver $25,000 – $49,999       

Prominent recognition as a Silver Sponsor with your logo and organization’s name displayed on the conference website, flyers, and on-site program. Option to sponsor (1) Morning or (1) Afternoon Coffee Break. On-site signage throughout the conference. Half-page advertisement in the on-site program (artwork subject to NYAS approval). 50% discount on exhibitor table in a high-traffic area. 5 – 10 complimentary registrations (based on level of support). 5 – 10 complimentary, 1-year individual Memberships to NYAS (based on level of support).

Bronze $10,000 – $24,999     

Prominent recognition as a Bronze Sponsor with your organization’s name displayed on the conference website, flyers, and on-site program. On-site signage throughout the conference. 25% discount on exhibitor table in a high-traffic area. 2 – 5 complimentary registrations (based on level of support). 2 – 5 complimentary, 1-year individual Memberships to NYAS (based on level of support).

Academy Friend $1,000 – $9,999    

Prominent recognition as an Academy Friend with your organization’s name displayed on the conference website and on-site program. On-site signage throughout the conference. 0 – 2 complimentary registrations (based on level of support). Up to 2 complimentary, 1-year individual Memberships to NYAS (based on level of support).

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Sponsorship Opportunities – Reach Our Global Community Annals Volume starting at $10,000 Annals of the New York Academy of Sciences is a premier scientific publication that is among the most highly cited general scientific serials. Annals provides a PubMed-indexed record of selected Academy conferences through more than 11,000 research libraries worldwide. Custom Annals sponsorship includes special acknowledgment of sponsor support in one of several available formats (design/wording subject to NYAS approval) and a substantial number of complimentary, branded copies of the volume to send to your contacts. Pricing starts at $10,000 for 150 copies of your branded Annals volume and $15,000 for 250 copies (assuming standard size and format). In addition, sponsors may support open online access of the Annals volume or specific articles, with special acknowledgment (price available upon request). All Bronze Sponsor benefits are included.

Podcast $4,000 Sponsor one of the extremely popular Academy podcasts that are available through www.nyas.org and iTunes. Our podcasts may be sampled at http://www.nyas.org/whatwedo/scpodcasts.aspx. o Academy podcasts are downloaded an average of 35,000 times each month and have recorded more than 2.7 million total downloads since inception. All Academy Friend benefits are included.

Travel Scholarships $5,000 and up Give multiple students, fellows, and junior investigators the opportunity to attend and present their research at this conference. Your contribution will help defray travel costs for these scientists and foster their ability to form valuable professional networks. Travel scholarship awardees will be acknowledged in the on-site program as “(Sponsor’s Name) Fellows.” All Academy Friend benefits are included.

Speaker Sponsorship $1,500 – $2,000 Help bring experts to this important conference. Your organization’s contribution would help to defray the cost of a conference speaker’s travel and accommodations. You may indicate which speaker on the conference agenda you would like to sponsor. Their presentation will be announced during the conference and appear in the on-site program as “The (Sponsor’s Name) Lecture.” All Academy Friend benefits are included.

Exhibitor Booth $5,000 and up Increase your exposure at the event by exhibiting your booth or pop-up display in a high-traffic area. Booth location will be determined by level of support. All Academy Friend benefits are included.

Poster Session Sponsorship $5,000 Gain visibility in one of the more highly trafficked areas of the conference. Poster sessions feature the work of up-and-coming scientists in the field. “Thank you” signs featuring your logo will be provided. All Academy Friend benefits are included.

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Sponsorship Opportunities – Exhibitor and Hospitality Support Coffee Breaks $7,500 Feature your brand during the popular morning or afternoon coffee breaks. o Attendees will appreciate your contribution to their energy boost with coffee, tea, and other beverages and snacks available. o “Thank you” signs featuring your logo will be provided. A package discount for sponsorship of multiple coffee breaks is also available. Please contact us for full details. All Academy Friend benefits are included.

Continental Breakfast $10,000 Help attendees start the conference day with your branded breakfast. o Branded signage will remind participants of your hospitality and sponsorship. o In addition, your company materials or branded coffee cups can be displayed on tables for further visibility (materials are subject to NYAS approval). o At breakfast, your company representatives will have a unique opportunity to greet the attendees and make new contacts. All Bronze Sponsor benefits are included.

Lunch $15,000 Gain visibility during critical lunchtime networking. o Branded signage will remind participants of your hospitality and sponsorship. o In addition, your literature and company materials can be displayed on tables for further visibility (materials are subject to NYAS approval). o At the luncheon, your representatives will have a unique opportunity to greet the attendees and make new contacts. All Bronze Sponsor benefits are included.

Networking Reception $25,000 and up Headline a special, upscale evening networking event for the conference participants, in one of the most highly trafficked areas of the conference. o Branded signage will remind participants of your hospitality and sponsorship. o In addition, your literature and company materials can be displayed throughout the reception for further visibility (materials are subject to NYAS approval). o During the evening, your representatives will have access to greet the attendees and make new contacts. All Silver Sponsor benefits are included. If you require more details on any of the sponsorship packages or would like to request a custom proposal, please contact Dr. Erick T. Tatro at [email protected] or 212.298.8648.

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Academy Exhibitor Space The New York Academy of Sciences Conference Center offers exhibitors the opportunity to interact with conference attendees in an intimate setting.

Exhibitor Booth ($5,000) 

Exhibitor booths are available in high-traffic and high-visibility areas and share the same space as many of the program’s networking events, such as the poster session and reception.

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Exhibitors may choose to have representatives present at their booth at all times and in particular during breaks and networking events.

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This option includes 2 complimentary registrations for representatives of your organization to attend the conference and receive all accompanying materials, such as the pre-event attendee contact list with email addresses and affiliations.

Exhibitor Booth at Location A

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NYAS provides “Exhibitor” badge ribbons for the 2 complimentary registrants and for any additional employees your company may choose to register to attend this event.

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NYAS provides: o A 6 foot table with 2 chairs at a high-traffic location in the conference center lobby (exact location determined by conference staff closer to event date; see attached floor plan for options). o Convenient access to power supply and free wireless Internet access.

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NYAS invites your company’s exhibition team to bring or ship to us in advance: o Branded marketing materials for distribution. o Penguin stands or similar display banners. o Branded linens and other exhibitor booth elements.

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All other “Academy Friend” Benefits included!

FLOOR PLAN

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Conference Agenda The Addicted Brain and New Treatment Frontiers: 6th Annual Aspen Brain Forum May 18 – 20, 2016 The New York Academy of Sciences Conference Center 7 World Trade Center, 250 Greenwich Street, 40th Floor, New York, NY 10007

Day 1: Wednesday, May 18, 2016 5:00 PM

Registration

5:45 PM

Welcome and Introductory Remarks

6:00 PM

Public Lecture

Arrested Development: The Teenage Brain and Substance Abuse Panel Discussion Moderator: Panelists:

To Be Announced Judge Greg Canova, JD, King County Washington Superior Court; Drug Court (2000 – 2015) Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health Additional Panelists to Be Announced

7:00 PM

Reception

7:45 PM

Public Lecture Adjourns

Day 2: Thursday, May 19, 2016 7:30 AM

Registration, Continental Breakfast, and Poster Session I Setup

8:30 AM

Opening Remarks

8:45 AM

KEYNOTE ADDRESS #1 Disease of Addiction: Significance to Brain Development, Function, and Behavior Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health

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Session I: Mechanisms of Neuroplasticity in Addiction Session Chair:

George F. Koob, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health

9:30 AM

Long-term Synaptic Changes that Mediate Addiction Peter W. Kalivas, PhD, Medical University of South Carolina

10:00 AM

The Neural Basis of Learning Mechanisms Underlying Addiction Barry J. Everitt, ScD, University of Cambridge

10:30 AM

Neural Circuitry of Emotional Behavior Mediated by Chronic Drug and Alcohol Abuse Thomas Kash, PhD, University of North Carolina School of Medicine

11:00 AM

Networking Coffee Break

11:30 AM

Tolerance and Dependence: Neural Adaptations to Chronic Drug and Alcohol Exposure David M. Lovinger, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health

12:00 PM

Optical De(Re)construction of Neural Systems: Applications to Research on Addiction Neuroscience Michael R. Bruchas, PhD, Washington University School of Medicine

12:30 PM

Networking Lunch

1:00 PM

Early Career Investigator Mentoring Workshop Recommended for Graduate Students, Post-doctoral Fellows, and Junior Faculty Editor's Guide to Writing and Publishing Your Paper Brooke Grindlinger, PhD, The New York Academy of Sciences Former Editor, The Journal of Clinical Investigation In this 45-minute workshop participants will gain an inside look into the editorial review process and how to best present the results of their work for publication.

Session II: Adolescent Brain Development and Susceptibility in Addiction Session Chair:

Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health

2:00 PM

Transcriptional and Epigenetic Mechanisms of Addiction Eric J. Nestler, MD, PhD, Icahn School of Medicine at Mount Sinai Hospital

2:30 PM

Alcohol’s Dynamic Effect on Neurodevelopment Susan F. Tapert, PhD, University of California San Diego

3:00 PM

Cannabis and Neurodevelopment in Adolescence Staci Gruber, PhD, McLean Hospital, Harvard Medical School

3:30 PM

Networking Coffee Break

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4:00 PM

Neurobiologic Approaches to Teenage Addiction Treatment and Prevention Diana Fishbein, PhD, Pennsylvania State University

4:30 PM

Safety and Clinical Issues of Electronic Cigarettes and Adolescence Thomas Eissenberg, PhD, Virginia Commonwealth University

Session III: Hot Topic Talks from Submitted Abstracts Session Chair:

Joseph Dial, Chairman, Scientific Advisory Board, The Aspen Brain Forum Foundation

5:00 PM

Title to Be Announced Speaker to Be Selected from a Competitive Review Process

5:15 PM

Title to Be Announced Speaker to Be Selected from a Competitive Review Process

5:30 PM

Networking Reception and Poster Session I

7:00 PM

Conference Day 2 Adjourns

Day 3: Friday, May 20, 2016 7:45 AM

Poster Session II Setup

7:45 AM

Continental Breakfast

8:15 AM

KEYNOTE ADDRESS #2 Dark Side of Addiction: Alcohol Abuse and the Stress System George F. Koob, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health

Session IV: New Horizons for Treatment Strategies Session Chair:

Orla M. Smith, PhD, Science Translational Medicine

9:00 AM

Optogenetically-inspired Deep Brain Stimulation Reverses Cocaine-Evoked Synaptic Plasticity Meaghan Creed, PhD, University of Geneva

9:30 AM

Immune-based Therapies for Substance Dependence Ronald G. Crystal, MD, Weill Cornell Medical College

10:00 AM

Networking Coffee Break

10:30 AM

Pharmacologic Approaches to Resolving the Opioid Epidemic David R. Gastfriend, MD, Treatment Research Institute

11:00 AM

Personalized Treatment Using Genetics: An Illustration from Tobacco Rachel F. Tyndale, PhD, University of Toronto

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Session V: Hot Topic Talks from Submitted Abstracts Session Chair:

To Be Announced

11:30 AM

Title to Be Announced Speaker to Be Selected from a Competitive Review Process

11:45 AM

Title to Be Announced Speaker to Be Selected from a Competitive Review Process

12:00 PM

Networking Lunch and Poster Session II

Session VI: Neuroscience to Action: What’s Wrong and What Can We Fix? Session Chair:

Peter Kalivas, PhD, Medical University of South Carolina

1:30 PM

State of the Science of Cannabis Research: Update from the NIH Marijuana Summit, March 2016 Susan R. B. Weiss, PhD, National Institute on Drug Abuse, U.S. National Institutes of Health

2:00 PM

Translational Overview of the Neurobiology of Addiction and Societal Implications Yasmin Hurd, PhD, Icahn School of Medicine at Mount Sinai Hospital

2:30 PM

Neurobiology of Decision-Making and Willful Choice in the Context of Addiction Read Montague, PhD, Virginia Tech Carilion Research Institute

3:00 PM

Networking Coffee Break

3:30 PM

Optimizing Public Health and Safety in the Face of Addiction Mark Kleiman, MPP, PhD, University of California, Los Angeles

4:00 PM

Healthcare Systems and Policy in the Management of Care for Addiction A. Thomas McLellan, PhD, University of Pennsylvania

4:30 PM

Introduction by Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health Alcohol and Substance Addiction: The Next Civil Rights Movement Honorable Patrick J. Kennedy, Former U.S. Representative, Rhode Island; One Mind for Research; and Kennedy Forum

5:00 PM

Closing Remarks

5:15 PM

Conference Concludes

Sponsorship Opportunities — The Addicted Brain & New Treatment Frontiers: 6th Aspen Brain Forum │16

Contact Information If you require more details on any of the conference sponsorship packages or would like to request a custom proposal, please contact: Melanie Brickman Stynes, PhD, MSc Director, Life Sciences Conferences The New York Academy of Sciences 7 World Trade Center, 250 Greenwich St, 40th Fl New York, NY 10007-2157 Phone: 212.298.8655 Email: [email protected]

Erick T. Tatro, PhD Program Manager, Life Sciences The New York Academy of Sciences 7 World Trade Center, 250 Greenwich St, 40th Fl New York, NY 10007-2157 Phone: 212.298.8648 Email: [email protected]

Sponsorship Opportunities — The Addicted Brain & New Treatment Frontiers: 6th Aspen Brain Forum │17